Group Family Subfamily Tetrahymena Dictyostelium Yeast Worm Fly Urchin Human Leftover class? Predicted History Atypical FAST 0 0 0 0 0 0 1 Chordate Atypical H11 0 0 0 0 0 0 1 Chordate Other NKF5 0 0 0 0 0 0 2 Chordate TK Axl 0 0 0 0 0 0 3 Chordate AGC AktR 20 0 0 0 0 0 0 Ciliate CAMK CAMK-Tt 5 0 0 0 0 0 0 Ciliate Other Ciliate-A1 6 0 0 0 0 0 0 Ciliate Other Ciliate-A2 15 0 0 0 0 0 0 Ciliate Other Ciliate-A3 4 0 0 0 0 0 0 Ciliate Other Ciliate-A4 6 0 0 0 0 0 0 Ciliate Other Ciliate-A5 10 0 0 0 0 0 0 Ciliate Other Ciliate-A6 9 0 0 0 0 0 0 Ciliate Other Ciliate-A7 11 0 0 0 0 0 0 Ciliate Other Ciliate-A8 11 0 0 0 0 0 0 Ciliate Other Ciliate-A9 6 0 0 0 0 0 0 Ciliate Other Ciliate-B1 8 0 0 0 0 0 0 Ciliate Other Ciliate-B2 8 0 0 0 0 0 0 Ciliate Other Ciliate-B3 4 0 0 0 0 0 0 Ciliate Other Ciliate-C1 6 0 0 0 0 0 0 Ciliate Other Ciliate-C3 5 0 0 0 0 0 0 Ciliate Other Ciliate-C4 6 0 0 0 0 0 0 Ciliate Other Ciliate-C5 15 0 0 0 0 0 0 Ciliate Other Ciliate-C6 12 0 0 0 0 0 0 Ciliate Other Ciliate-C7 50 0 0 0 0 0 0 Ciliate Other Ciliate-C8 C8 39 0 0 0 0 0 0 Ciliate Other Ciliate-C8 C2 17 0 0 0 0 0 0 Ciliate Other Ciliate-D1 146 0 0 0 0 0 0 Ciliate Other Ciliate-E1 61 0 0 0 0 0 0 Ciliate Other Ciliate-E2 99 0 0 0 0 0 0 Ciliate Other Ciliate-E3 6 0 0 0 0 0 0 Ciliate Other Ciliate-E4 4 0 0 0 0 0 0 Ciliate Other Ciliate-E5 9 0 0 0 0 0 0 Ciliate Other Ciliate-E6 11 0 0 0 0 0 0 Ciliate Other Ciliate-E7 4 0 0 0 0 0 0 Ciliate Other Ciliate-E8 3 0 0 0 0 0 0 Ciliate Other Ciliate-E9 3 0 0 0 0 0 0 Ciliate Other Ciliate-F1 2 0 0 0 0 0 0 Ciliate Other Ciliate-F2 2 0 0 0 0 0 0 Ciliate TKL TKL-ciliate1 2 0 0 0 0 0 0 Ciliate TKL TKL-ciliate2 2 0 0 0 0 0 0 Ciliate CAMK CDPK 20 0 0 0 0 0 0 Ciliates+plants CAMK Trbl 0 0 0 0 1 1 3 Coelomate CMGC CDK CDK10 0 0 0 0 1 2 1 Coelomate Other IKK 0 0 0 0 2 3 4 Coelomate Other MOS 0 0 0 0 1 2 1 Coelomate Other TOPK 0 0 0 0 1 1 1 Coelomate STE STE20 NinaC 0 0 0 0 1 1 2 Coelomate TK CCK4 0 0 0 0 1 1 1 Coelomate TK Jak 0 0 0 0 1 2 4 Coelomate TK Musk 0 0 0 0 1 1 1 Coelomate TK PDGFR/VEGFR 0 0 0 0 2 2 8 Coelomate TK Ret 0 0 0 0 1 1 1 Coelomate TK Sev 0 0 0 0 1 1 1 Coelomate TK Tec 0 0 0 0 1 1 5 Coelomate TKL LISK LIMK 0 0 0 0 1 1 2 Coelomate TKL LISK TESK 0 0 0 0 1 1 2 Coelomate Atypical Alpha ChaK 0 0 0 0 0 2 2 Deuterostome Atypical BCR 0 0 0 0 0 1 1 Deuterostome CAMK CAMKL HUNK 0 0 0 0 0 1 1 Deuterostome CAMK Trio 0 0 0 0 0 1 6 Deuterostome Other NKF3 0 0 0 0 0 1 2 Deuterostome Other NKF4 0 0 0 0 0 1 2 Deuterostome TK Lmr 0 0 0 0 0 1 3 Deuterostome TK Tie 0 0 0 0 0 1 2 Deuterostome TKL RIPK 0 0 0 0 0 8 5 Deuterostome Atypical AFK 0 4 0 0 0 0 0 Dictyostelium Atypical Alpha MHCK 0 4 0 0 0 0 0 Dictyostelium CMGC CDK CDK-DD1 0 3 0 0 0 0 0 Dictyostelium CMGC Dicty1 0 3 0 0 0 0 0 Dictyostelium Other Dicty10 0 2 0 0 0 0 0 Dictyostelium Other Dicty6 0 2 0 0 0 0 0 Dictyostelium Other Dicty7 0 2 0 0 0 0 0 Dictyostelium Other Dicty8 0 2 0 0 0 0 0 Dictyostelium Other Dicty9 0 6 0 0 0 0 0 Dictyostelium Other SAMK 0 4 0 0 0 0 0 Dictyostelium STE Dicty2 0 5 0 0 0 0 0 Dictyostelium STE Dicty3 NZAK 0 2 0 0 0 0 0 Dictyostelium STE Dicty3 FNIPK 0 6 0 0 0 0 0 Dictyostelium STE STE20 Ste20-DD1 0 2 0 0 0 0 0 Dictyostelium STE STE20 PAKL 0 4 0 0 0 0 0 Dictyostelium STE STE20 MKC 0 6 0 0 0 0 0 Dictyostelium TKL ARK 0 9 0 0 0 0 0 Dictyostelium TKL ARMK 0 2 0 0 0 0 0 Dictyostelium TKL CZAK 0 5 0 0 0 0 0 Dictyostelium TKL Dicty4 DRK 0 4 0 0 0 0 0 Dictyostelium TKL Dicty4 Shk 0 5 0 0 0 0 0 Dictyostelium TKL Dicty5 0 4 0 0 0 0 0 Dictyostelium TKL DPYK 0 2 0 0 0 0 0 Dictyostelium TKL Gdt 0 6 0 0 0 0 0 Dictyostelium TKL LISK LISK-DD1 0 9 0 0 0 0 0 Dictyostelium Other urch 0 0 0 0 0 29 0 Echinoderm TK TK-Sp1 0 0 0 0 0 3 0 Echinoderm TKL TKL-Sp1 0 0 0 0 0 7 0 Echinoderm AGC AGC-Unique 0 1 0 1 0 0 0 y Leftover class AGC DMPK DMPK-Unclassified 0 0 0 0 1 1 1 y Leftover class AGC PKC PKC-Unclassified 0 0 1 0 0 0 0 y Leftover class AGC RSK RSK-Unclassified 2 0 2 0 0 0 0 y Leftover class Atypical Alpha Alpha-Unclassified 0 2 0 0 0 0 3 y Leftover class CAMK CAMKL CAMKL-Unclassified 2 1 0 0 0 0 0 y Leftover class CAMK CAMK-Unique 2 0 4 0 1 2 3 y Leftover class CK1 CK1 CK1-Unclassified 19 0 0 6 3 0 0 y Leftover class CMGC CDK CDK-Unclassified 1 0 2 1 1 1 1 y Leftover class CMGC CMGC-Unique 1 2 1 1 0 0 0 y Leftover class CMGC MAPK MAPK-Unclassified 3 0 0 3 0 0 0 y Leftover class Other Other-Unique 18 13 3 10 1 7 7 y Leftover class Other PEK PEK-Unclassified 1 1 0 0 0 1 2 y Leftover class STE Dicty3 Dicty3-Unclassified 0 2 0 0 0 0 0 y Leftover class STE STE20 Ste20-Unclassified 0 2 0 0 0 0 0 y Leftover class STE Ste-Unique 0 4 0 1 1 0 3 y Leftover class TK TK-Unique 0 0 0 7 4 12 1 y Leftover class TKL Dicty4 Dicty4-Unclassified 0 2 0 0 0 0 0 y Leftover class TKL TKL-Unique 1 8 0 0 0 1 1 y Leftover class AGC DMPK ROCK 0 0 0 1 1 1 2 Metazoan AGC DMPK GEK 0 0 0 1 1 1 4 Metazoan AGC GRK GRK 0 0 0 1 1 1 5 Metazoan AGC GRK BARK 0 0 0 1 1 1 2 Metazoan AGC PKC PKC-Delta 0 0 0 1 1 1 2 Metazoan AGC PKC PKC-Eta 0 0 0 1 1 1 2 Metazoan AGC PKC PKC-Iota 0 0 0 1 1 1 2 Metazoan AGC PKC PKC-Alpha 0 0 0 1 2 1 3 Metazoan AGC PKG 0 0 0 2 3 2 2 Metazoan AGC PKN 0 0 0 1 1 1 3 Metazoan AGC RSK MSK 0 0 0 1 1 2 2 Metazoan AGC RSKL 0 0 0 1 1 1 2 Metazoan AGC RSKR 0 0 0 1 1 1 1 Metazoan AGC YANK 0 0 0 1 1 1 3 Metazoan Atypical RIO RIO3 0 0 0 1 1 1 1 Metazoan CAMK CAMK2 0 0 0 1 1 1 4 Metazoan CAMK CAMKL NuaK 0 0 0 1 1 1 2 Metazoan CAMK CAMKL NIM1 0 0 0 1 1 1 1 Metazoan CAMK CAMKL SNRK 0 0 0 1 1 1 1 Metazoan CAMK CASK 0 0 0 1 1 1 1 Metazoan CAMK DAPK 0 0 0 1 1 2 5 Metazoan CAMK DCAMKL 0 0 0 2 1 2 3 Metazoan CAMK MAPKAPK MNK 0 0 0 1 1 1 2 Metazoan CAMK MAPKAPK MAPKAPK 0 0 0 2 1 3 3 Metazoan CAMK MLCK 0 0 0 5 5 6 5 Metazoan CAMK PHK 0 0 0 1 1 1 2 Metazoan CAMK PKD 0 0 0 2 1 1 3 Metazoan CAMK TSSK 0 0 0 3 2 5 5 Metazoan CK1 CK1 CK1-A 0 0 0 1 2 2 2 Metazoan CK1 VRK 0 0 0 1 2 1 3 Metazoan CMGC CDK CDK4 0 0 0 1 1 1 2 Metazoan CMGC CDK CDK9 0 0 0 1 1 1 1 Metazoan CMGC CDK TAIRE 0 0 0 2 1 1 5 Metazoan CMGC DYRK HIPK 0 0 0 1 1 1 4 Metazoan CMGC MAPK JNK 0 0 0 5 1 1 3 Metazoan CMGC MAPK nmo 0 0 0 1 1 1 1 Metazoan CMGC MAPK p38 0 0 0 3 3 1 4 Metazoan Other NKF1 0 0 0 1 2 1 3 Metazoan Other NKF2 0 0 0 1 1 1 1 Metazoan Other NRBP 0 0 0 1 1 1 2 Metazoan RGC RGC 0 0 0 27 6 8 5 Metazoan STE STE20 PAKB 0 0 0 1 1 1 3 Metazoan STE STE20 TAO 0 0 0 1 1 1 3 Metazoan STE STE20 SLK 0 0 0 1 1 1 2 Metazoan STE STE20 STLK 0 0 0 2 1 1 2 Metazoan STE STE20 KHS 0 0 0 1 1 1 4 Metazoan STE STE20 MSN 0 0 0 1 1 1 4 Metazoan TK Abl 0 0 0 1 1 1 2 Metazoan TK Ack 0 0 0 2 2 3 2 Metazoan TK ALK 0 0 0 1 1 1 2 Metazoan TK Csk 0 0 0 1 1 2 2 Metazoan TK DDR 0 0 0 2 1 1 2 Metazoan TK EGFR 0 0 0 1 1 1 4 Metazoan TK Eph 0 0 0 1 1 1 14 Metazoan TK FAK 0 0 0 1 1 1 2 Metazoan TK Fer 0 0 0 38 1 1 2 Metazoan TK FGFR 0 0 0 1 2 1 4 Metazoan TK InsR 0 0 0 1 1 2 3 Metazoan TK ROR 0 0 0 1 1 1 2 Metazoan TK Ryk 0 0 0 1 3 1 1 Metazoan TK Src 0 0 0 3 2 7 11 Metazoan TKL IRAK 0 0 0 1 1 2 4 Metazoan TKL MLK ILK 0 0 0 1 1 1 1 Metazoan TKL MLK TAK1 0 0 0 2 3 1 1 Metazoan TKL MLK LZK 0 0 0 1 1 1 2 Metazoan TKL MLK MLK 0 0 0 2 1 1 5 Metazoan TKL RAF 0 0 0 3 2 3 5 Metazoan TKL STKR Type2 0 0 0 1 2 3 5 Metazoan TKL STKR Type1 0 0 0 2 3 3 7 Metazoan Atypical Alpha eEF2K 0 0 0 1 0 1 1 "Metazoan, lost in insects" CAMK CAMKL MELK 0 0 0 1 0 1 1 "Metazoan, lost in insects" CAMK PIM 0 0 0 2 0 1 3 "Metazoan, lost in insects" CAMK PSK 0 0 0 1 0 1 2 "Metazoan, lost in insects" TK Met 0 0 0 2 0 1 2 "Metazoan, lost in insects" TK Trk 0 0 0 1 0 1 3 "Metazoan, lost in insects" TK Syk 0 0 0 0 1 2 2 "Metazoan, lost in worm (due to Hydra homolog)" CK1 Dual 0 0 0 6 0 0 0 Nematode CK1 TTBKL 0 0 0 31 0 0 0 Nematode CK1 Worm10 0 0 0 2 0 0 0 Nematode CK1 Worm11 0 0 0 1 0 0 0 Nematode CK1 Worm6 0 0 0 28 0 0 0 Nematode CK1 Worm7 0 0 0 2 0 0 0 Nematode CK1 Worm8 0 0 0 3 0 0 0 Nematode CK1 Worm9 0 0 0 2 0 0 0 Nematode Other Worm1 0 0 0 2 0 0 0 Nematode Other Worm2 0 0 0 3 0 0 0 Nematode Other Worm3 0 0 0 2 0 0 0 Nematode Other Worm4 0 0 0 1 0 0 0 Nematode Other Worm5 0 0 0 3 0 0 0 Nematode TK Kin-16 0 0 0 16 0 0 0 Nematode TK Kin-9 0 0 0 5 0 0 0 Nematode AGC RSK p70 0 0 1 2 1 1 2 Ophistokont Atypical PDHK 0 0 2 2 1 2 5 Ophistokont Atypical PIKK ATM 0 0 1 1 1 1 1 Ophistokont CAMK CAMKL CHK1 0 0 1 7 1 2 1 Ophistokont CK1 CK1 CK1-G 0 0 3 1 1 1 3 Ophistokont CAMK CAMKL PASK 0 0 2 0 1 1 1 "Ophistokont, lost in worm" AGC Akt 13 2 3 2 1 2 3 Primordial AGC NDR 5 6 4 2 2 2 4 Primordial AGC PDK1 1 2 3 2 1 1 1 Primordial AGC PKA 5 3 3 2 4 2 5 Primordial Atypical ABC1 ABC1-B 3 2 1 1 2 1 2 Primordial Atypical ABC1 ABC1-A 1 1 1 1 1 2 2 Primordial Atypical PIKK ATR 1 1 1 1 1 1 1 Primordial Atypical PIKK FRAP 2 1 2 1 1 1 1 Primordial Atypical RIO RIO1 1 1 1 1 1 1 1 Primordial Atypical RIO RIO2 1 1 1 1 1 1 1 Primordial Atypical TAF1 1 1 1 1 1 1 1 Primordial CAMK CAMK1 7 8 4 1 1 2 5 Primordial CAMK CAMKL AMPK 7 1 1 2 1 3 2 Primordial CAMK CAMKL MARK 11 3 1 2 3 1 4 Primordial CMGC CDK CRK7 1 1 1 1 1 1 2 Primordial CMGC CDK CDC2 11 1 1 2 2 2 3 Primordial CMGC CK2 3 2 2 1 1 1 2 Primordial CMGC CLK 1 1 1 3 1 1 4 Primordial CMGC GSK 6 2 4 7 3 1 2 Primordial CMGC MAPK ERK 8 1 6 1 1 3 5 Primordial CMGC RCK 8 1 1 1 1 2 3 Primordial CMGC SRPK 3 1 1 1 3 1 3 Primordial Other Aur 14 1 1 2 2 1 3 Primordial Other Bud32 1 1 1 1 1 1 1 Primordial Other CDC7 1 1 1 1 2 1 1 Primordial Other IRE 1 7 1 1 1 1 2 Primordial Other NAK 2 3 4 2 3 3 4 Primordial Other NEK 38 4 1 4 2 12 11 Primordial Other PEK GCN2 3 3 1 1 1 1 1 Primordial Other PLK 7 1 1 3 2 3 4 Primordial Other SCY1 1 2 1 2 4 3 3 Primordial Other ULK 57 2 1 2 3 4 5 Primordial Other VPS15 1 1 1 1 1 1 1 Primordial Other Wee 2 3 1 2 2 3 3 Primordial STE STE11 8 1 4 2 2 5 8 Primordial STE STE20 PAKA 2 4 3 2 2 1 3 Primordial STE STE20 YSK 1 1 2 1 1 1 3 Primordial STE STE20 MST 4 2 1 1 1 1 2 Primordial STE STE7 4 1 4 10 4 5 7 Primordial AGC RSK RSK 2 0 0 1 1 1 4 "Primordial, lost in Dicty, yeast" CMGC CDKL 4 0 0 1 1 3 5 "Primordial, lost in Dicty, yeast" Other TLK 2 0 0 1 1 1 2 "Primordial, lost in Dicty, yeast" Atypical HisK 83 14 1 0 0 0 0 "Primordial, lost in metazoans" Atypical Alpha VWL 9 ? 0 0 0 0 0 "Primordial, lost in ophistokont" AGC MAST 3 5 0 1 2 2 5 "Primordial, lost in Yeast" CMGC CDK PITSLRE 1 2 0 2 1 1 1 "Primordial, lost in yeast" CMGC DYRK PRP4 1 1 0 1 1 1 1 "Primordial, lost in Yeast" CMGC DYRK DYRK1 1 1 0 1 1 2 2 "Primordial, lost in Yeast" CMGC DYRK DYRK2 5 1 0 3 2 2 3 "Primordial, lost in Yeast" CMGC MAPK Erk7 3 1 0 1 1 1 1 "Primordial, lost in Yeast" Other WNK 2 0 0 1 1 1 4 "Primordial, lost in Yeast, Dicty" AGC SGK 2 2 0 1 0 1 3 "Primordial, lost in Yeast, fly" Atypical PIKK DNAPK 1 1 0 0 0 1 1 "Primordial, lost in yeast, worm, fly" Atypical PIKK TRRAP 0 1 1 1 1 1 1 Unikont CAMK RAD53 0 5 1 2 1 1 1 Unikont CK1 CK1 CK1-D 0 1 1 1 1 1 2 Unikont CMGC CDK CDK7 0 1 1 1 1 1 1 Unikont CMGC CDK CDK8 0 1 1 1 1 1 2 Unikont Other Bub 0 1 1 1 2 1 2 Unikont Other Haspin 0 1 2 13 1 1 1 Unikont Atypical ABC1 ABC1-C 0 1 1 1 0 1 1 "Unikont, lost in insects" CMGC DYRK YAK 0 1 1 0 0 0 0 "Unikont, lost in metazoans" Other IKS 0 1 1 0 0 0 0 "Unikont, lost in metazoans" Other TTK 0 1 1 0 1 1 1 "Unikont, lost in nematodes" Atypical BRD 0 2 0 3 1 1 4 "Unikont, lost in Yeast" Atypical PIKK SMG1 0 1 0 1 1 1 1 "Unikont, lost in Yeast" CAMK CAMKL BRSK 0 1 0 1 1 2 2 "Unikont, lost in Yeast" CAMK CAMKL LKB 0 1 0 1 1 1 1 "Unikont, lost in Yeast" CAMK CAMKL QIK 0 1 0 1 2 1 3 "Unikont, lost in Yeast" CK1 TTBK 0 1 0 1 1 1 2 "Unikont, lost in Yeast" CMGC CDK CDK5 0 1 0 1 1 1 1 "Unikont, lost in Yeast" Other CAMKK Meta 0 1 0 1 1 1 2 "Unikont, lost in Yeast" Other PEK PEK 0 2 0 2 1 1 1 "Unikont, lost in Yeast" Other TBCK 0 1 0 1 1 1 1 "Unikont, lost in Yeast" STE STE20 FRAY 0 2 0 1 1 1 2 "Unikont, lost in Yeast" TKL LRRK 0 11 0 1 1 4 2 "Unikont, lost in Yeast" TKL MLK HH498 0 1 0 1 0 1 1 "Unikont, lost in Yeast, insects" Atypical TIF1 0 1 0 0 1 1 3 "Unikont, lost in Yeast, nematodes" Other Slob 0 2 0 0 2 1 1 "Unikont, lost in Yeast, nematodes" Atypical G11 0 1 0 0 0 1 1 "Unikont, lost in Yeast, nematodes, insects" CAMK CAMKL Kin1 0 0 2 0 0 0 0 Yeast CAMK CAMKL Kin4 0 0 2 0 0 0 0 Yeast CAMK CAMKL GIN4 0 0 3 0 0 0 0 Yeast Other CAMKK ELM 0 0 3 0 0 0 0 Yeast Other HAL 0 0 9 0 0 0 0 Yeast Other RAN 0 0 3 0 0 0 0 Yeast