CLUSTAL W (1.83) multiple sequence alignment CG7236_Dmel YEKLSRLGEGSYGVVYKCRDRETGALVAVKRFVESED--DPAIRKIALREIRLLKNLKHP CDKL5_Mmus FEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEE--NEEVKETTLRELKMLRTLKQE CDKL4_Mmus YEKLAKIGEGSYGVVFKCRNKSSGQVVAIKKFVESED--DRVVRKIALREIRMLKQLKHP CDKL3_Mmus YETLGKVGEGSYGTVMKCKHKDTGRIVAIKIFYEKPE---KSVNKIATREIKFLKQFRHE CDKL2_Mmus YENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDD--DKMVKKIAMREIKLLKQLRHE CDKL1_Mmus YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKRFLETED--DPVIKKIALREIRMLKQLKHP CDKL1_Hsap YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESED--DPVIKKIALREIRMLKQLKHP CDKL2_Hsap YENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDD--DKMVKKIAMREIKLLKQLRHE CDKL5_Hsap FEILGVVGEGAYGVVLKCRHKATHEIVAIKKFKDSEE--NEEVKETTLRELKMLRTLKQE CDKL4_Hsap YEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESED--DPVVKKIALREIRMLKQLKHP CDKL3_Hsap YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPE---QSVNKIAMREIKFLKQFHHE Y42A5A.4_Cele YDRLSKLGEGSYGVVYKCKNRDTGQIVAIKKFVETED--DPHIKKIALREIRMLKQLKHQ 10873_Tthe YEILGVNGEGAYGVVLKCRNKETQEIVAIKKFKETED--DEIAKKNIQREVKMLRQLRHK 17811_Tthe -------------KLYKCLNKETQKIIAIKAYKLNIN--QVEEKKRIEREVKIKKMLHHK 29899_Tthe YEVKGVVGEGAYGVVLKCMNKENGEYVAIKKFKESDE--DEVVKKTTLREVKILRMLKQE 7414_Tthe YEILGVVGEGAYGVVLKCRNRETNEILAIKKFKETED--DELVRKNIQREVKMLKTLKHK CDKL2_Spur YESFGLVGEGSYGQVLKCRHKETNQVVAIKKFLEGED--DKMVKKIAMREVRMLKQLRHE CDKL1_Spur YERLGKIGEGSYGVVFKCRHKDTGTIVAIKRFVESED--DPLIKKIALREIRMLKQLKHE CDKL5_Spur ----------------------------IMKPECGKY--NEDVRRTILRELKLLRQLKQE AqueK106_Aque YEKISKIGEGSYGVVFKCRNKDTGQIVAIKKFVESED--DPIIKKIALREIRMLRQLKHG AqueK107_Aque YENLGLVGEGSYGMVMKCRHKDSSQLVAIKKFLETEN--DRMVKKIALREVRMLKQLRHE GK026_Glam YEILGVSGEGAYGVVLKCRNKETNELVAIKKFKDTDDPEDSTFKKTTLREVKILKNAQHP : .. **::: : :: CG7236_Dmel NLVSLLEVFRRKRRLHLVFEFCELTVLHELERH--PQGCPEHLTKQICYQTLLGVAYCHK CDKL5_Mmus NIVELKEAFRRRGKLYLVFEYVEKNMLELLEEM--PNGVPPEKVKSYIYQLIKAIHWCHK CDKL4_Mmus NLVNLIEVFRRKRKMHLVFEYCDHTLLNELERN--PNGVSDGVIKSVLWQTLQALNFCHK CDKL3_Mmus NLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHY--CHGLESKRLRKYLFQILRAIEYLHN CDKL2_Mmus NLVNLLEVCKKKKRWYLVFEFVDHTILDDLKLF--PNGLDYQVVQKYLFQIINGIGFCHS CDKL1_Mmus NLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRY--QRGVPEPLVKNITWQTLQAVNFCHK CDKL1_Hsap NLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRY--QRGVPEHLVKSITWQTLQAVNFCHK CDKL2_Hsap NLVNLLEVCKKKKRWYLVFEFVDHTILDDLELF--PNGLDYQVVQKYLFQIINGIGFCHS CDKL5_Hsap NIVELKEAFRRRGKLYLVFEYVEKNMLELLEEM--PNGVPPEKVKSYIYQLIKAIHWCHK CDKL4_Hsap NLVNLIEVFRRKRKMHLVFEYCDHTLLNELERN--PNGVADGVIKSVLWQTLQALNFCHI CDKL3_Hsap NLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHY--CHGLESKRLRKYLFQILRAIDYLHS Y42A5A.4_Cele NLVGLIEVFKRNRKLHLVFELCDRTVLHELEKN--PHGVNDELIKKIIYQLLEALKFCHS 10873_Tthe NIVDLIEAFKRKGRIYLVFEYVEKNLLEVLEEK--PTGLDHEVIRIIMYQLLKALHQCHK 17811_Tthe NIVDIIEICQKNNEIYIVEEYVEISLSNYLKQGSQQKGLDQNVIPNIMYQVLSSINQCHK 29899_Tthe NIVQLREAFRRKGKLYLVFEYVENNLLEILEER--PNGLDQDDVRKYIYQLCKSISYCNS 7414_Tthe NIVGLVEAFKRKGRIYLVFEYVEKNLLEVLEEK--PSGLD----------LLKALDHCHK CDKL2_Spur NLVNLIEVFRRKKRLYLVFEFMDHTVLDELEKY--PMGLDESLVRKYMWQILKGIEFCHI CDKL1_Spur NLVNLKEVFRRKKKLHLVFEYCDYTVLNTLEAN--VNGVPEGQGMNIVYQTLEAVNFCHQ CDKL5_Spur NIVELKEAFRRRGKLYLVFEYVEKNMLELLEEN--PKGVPPEKVR--------------- AqueK106_Aque NLVNLLEVFRRKRKLHLVFEYCDHTVLNELEAH--PRGLDETSAKRIIWQTLQGVNYCHH AqueK107_Aque NLVNLIEVFRRKKRLYLVFEFVDHTALDELDKY--PSGADESLVKKIMWQVLKGVEFCHQ GK026_Glam HIVCLKEAFKRKQRLYLVFEYCEKTLLELIEDS--PGGIPIETVKLLTFQMLRGVEFLWE ::* : * ::. . ::* * : . . :. * CG7236_Dmel -QGCLHRDIKPENILLTAQ---GQVKLCDFGFARMLS-----------PGENYTDYVATR CDKL5_Mmus -NDIVHRDIKPENLLISHN---DVLKLCDFGFARNLSEG---------NNANYTEYVATR CDKL4_Mmus -HNCIHRDVKPENILITKQ---GMIKICDFGFARILI-----------PGDAYTDYVATR CDKL3_Mmus -NNIIHRDIKPENILVSQS---GITKLCDFGFARTLAA----------PGDVYTDYVATR CDKL2_Mmus -HNIIHRDIKPENILVSQS---GVVKLCDFGFARTLAA----------PGEVYTDYVATR CDKL1_Mmus -HNCIHRDVKPENILITKQ---SAIKLCDFGFARLLTG----------PGDYYTDYVATR CDKL1_Hsap -HNCIHRDVKPENILITKH---SVIKLCDFGFARLLTG----------PSDYYTDYVATR CDKL2_Hsap -HNIIHRDIKPENILVSQS---GVVKLCDFGFARTLAA----------PGEVYTDYVATR CDKL5_Hsap -NDIVHRDIKPENLLISHN---DVLKLCDFGFARNLSEG---------NNANYTEYVATR CDKL4_Hsap -HNCIHRDIKPENILITKQ---GIIKICDFGFAQILI-----------PGDAYTDYVATR CDKL3_Hsap -NNIIHRDIKPENILVSQS---GITKLCDFGFARTLAA----------PGDIYTDYVATR Y42A5A.4_Cele -HKCIHRDVKPENIFLTRN---DQVKLGDFGFARIIN-----------TTEMYTDYVATR 10873_Tthe -QDVIHRDVKPENLLVNPYN--YELKLCDFGFARTLPSK---------QGEIITDYVATR 17811_Tthe -YDIIHQNIKPMHIYINPSN--YELKLNGFRLARQLPQ----------KGEIVTDYVEAR 29899_Tthe -MDIIHRDIKPENLLISKD---GTLKLCDFGFARVLPQ----------KGGNLTDYVATR 7414_Tthe -HNIIHRDIKPENLLVNSD---GTLKLCDFGFARHMPPK---------QNEILTDYVATR CDKL2_Spur -NNIIHRDIKPENILVSKS---KVVKLCDFGFARTIAG----------PGEIYTDYVATR CDKL1_Spur -HNCIHRDVKPENILITKD---GRIKLCDFGFARILTG----------PDDEYTDYVATR CDKL5_Spur -NDVIHRDIKPENLLISAK---DTLKLCDFGFARNLDGN---------SSANYTDYVATR AqueK106_Aque -QN--------------------------------------------------------- AqueK107_Aque -HNVIHRDVKPENILISKR---GVVKICDFGFARAIAP----------PGEAYTDYVATR GK026_Glam FMEICHRDLKPENLLLVKKHGEWTLKLCDFGFARHINGAQTAGAAGNFPQSNLTDYVATR CG7236_Dmel WYRAPELLVGDTQYGTPVDVWAIGCLFAELVRGEALWPGRSDVDQLYLIRKTLGDLLPRH CDKL5_Mmus WYRSPELLLGA-PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQ CDKL4_Mmus WYRAPELLVGDTKYGSSVDVWAVGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRH CDKL3_Mmus WYRAPELVLKDTSYGKPVDIWALGCMIIEMATGHPFLPSSSDLDLLHKIVLKVGNLTPHL CDKL2_Mmus WYRAPELLVGDVKYGKAVDIWAIGCLVIEMLMGQPLFPGESDIDQLHHIMTCLGNLIPRH CDKL1_Mmus WYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRH CDKL1_Hsap WYRSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRH CDKL2_Hsap WYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRH CDKL5_Hsap WYRSPELLLGA-PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQ CDKL4_Hsap WYRAPELLVGDTQYGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRH CDKL3_Hsap WYRAPELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHL Y42A5A.4_Cele WYRSPELLVGDVQYGPPVDIWAVGCVYAELLTGEALWPGRSDIDQLYHIRKTLGEFLPRH 10873_Tthe WYRAPELLLKYPKYSKPVDIWAVACIMGELIDGQPLFPGQNEIDQLYLIQKTLGPLTPEQ 17811_Tthe WYKSPEYLLDYRKYGKPEDIWAAACVMAELIDGEPLFPGQGEIDQFYRIVQVIGPLTNQY 29899_Tthe WYRAPELLLGYTDYGKEVDMWAVGCIMGELTDGQPLFPGQNEIDQLYVIQKVLGPLTAEQ 7414_Tthe WYRSPELLLSDPGYSFPVDNWAIACIMGELIDGQPLFPGENEIDQLYLIQKLLGPLTPDQ CDKL2_Spur WYRAPELLVGDTKYGKAIDLWAVGCLQAEMLTGEPLFPGDSDIDQLYHIIRCFGTLIQRH CDKL1_Spur WYRAPELLVGDMVYGPPVDVWAIGCVTAELIAGEALWPGRSDVDQLYLIKQTLGDLIDRH CDKL5_Spur WYRSPELLLGS-AYGKAVDVWAIGCILGELSDGNAIFPGESEIDQLYM------------ AqueK106_Aque ----------------------------------PLWPGRSDVDQLHLIIQTQGDLIPYH AqueK107_Aque WYRAPELLVGDTNYGRAVDVWAIGCLFSEMLTGEPLFPGESDIDQLYLITKCFGNLIARH GK026_Glam WYRSPELLLNATDYNQTVDIWAAALIISEMITSEPLFAGDSDVDQLYLIQRVLGNLTRKQ . .. .::* :. CG7236_Dmel IQIFGQNEYFKGITLPVPPT--LEPLEDKMP-AKSQQNPLTIDFL-KKCLDKDPTKRWSC CDKL5_Mmus MKLFYSNPRFHGLRFPAVNH--PQSLERRYLGIL---NSVLLDLM-KNLLKLDPADRYLT CDKL4_Mmus QSIFRSNQFFRGISIPEPED--METLEEKFS-NV---QPVALSFM-KGCLKMNPDERLTC CDKL3_Mmus HNIFSKSPIFAGVVLPQVQH--PKTARKKYP-KL---NGLLADIV-HACLQIDPAERTSS CDKL2_Mmus QELFYKNPVFAGVRLPEVKDAEAEPLESRYP-KL---PEAVISLA-KKCLHIDPDKRPFC CDKL1_Mmus QQVFSMNQYFSGVKIPDPED--METLELKFP-NI---SYSALGFL-KGCLHMDPAERLTC CDKL1_Hsap QQVFSTNQYFSGVKIPDPED--MEPLELKFP-NI---SYPALGLL-KGCLHMDPTQRLTC CDKL2_Hsap QELFNKNPVFAGVRLPEIKE--REPLERRYP-KL---SEVVIDLA-KKCLHIDPDKRPFC CDKL5_Hsap MKLFYSNPRFHGLRFPAVNH--PQSLERRYLGIL---NSVLLDLM-KNLLKLDPADRYLT CDKL4_Hsap QSIFKSNGFFHGISIPEPED--METLEEKFS-DV---HPVALNFM-KGCLKMNPDDRLTC CDKL3_Hsap QNIFSKSPIFAGVVLPQVQH--PKNARKKYP-KL---NGLLADIV-HACLQIDPADRISS Y42A5A.4_Cele ISIFRTNQFFFGLSIPEPEH--LEPLPSKLP-NA---SSAQLDFL-QKCFEMSPDRRFSC 10873_Tthe KELFIKNPRFIGTKFPEINK--PETIERRYLGKL---SKKALNIM-KLMLKMDPDERITA 17811_Tthe ENLFKKK--YKDLKFPIIKN--FNSIELRYQGKI---NAEGLDLM-KMMLKMNPDERITA 29899_Tthe QEVFLKHPGFLGVKLPEISK--PETIEKRYLGKL---SKKALSFM-KNLLKMDPSQRMSA 7414_Tthe KEMFIKNPRYVGLKFPEIPK--PETIERRYLGKL---SKKALTFM-KGLLKMDPRERMNV CDKL2_Spur KEIFLKNPLFVGMRLPEVKN--VEPLEKRFP-TL---SGLSISMM-KSCLHLDPDQRPTC CDKL1_Spur SKIFSTNHFFKGMSIPEPER--RIPLKDKVR-NL---NSTALTFL-EACLQMDPADRLSC CDKL5_Spur ------------------------------------------------------------ AqueK106_Aque VKIFQESTYFKDTSIPCPDK--REPISALYP-QF---SQQILSFLEQGCLAMDPIARQTA AqueK107_Aque REVFSRNPLFIGMRLPEARE--IQPFERRYH-RL---SPAAMDII-KWSLRLDPADRPTC GK026_Glam MEKFLRNPKFIGVEFPTS-R--PEGLEKKLTGKIK--DKQAISLL-KMMLKMDPAERPSA CG7236_Dmel EKLTKHSYF CDKL5_Mmus EQCLNHPTF CDKL4_Mmus AQLLDSAYF CDKL3_Mmus TDLLRHDYF CDKL2_Mmus ADLLRHDFF CDKL1_Mmus EQLLQHPYF CDKL1_Hsap EQLLHHPYF CDKL2_Hsap AELLHHDFF CDKL5_Hsap EQCLNHPTF CDKL4_Hsap SQLLESSYF CDKL3_Hsap SDLLHHEYF Y42A5A.4_Cele SELMLHGIF 10873_Tthe EEAMKHPYF 17811_Tthe EQSLSHPFF 29899_Tthe DEALQHPYF 7414_Tthe QEAMAHPLF CDKL2_Spur TQFLKHEFF CDKL1_Spur QELMEMPFF CDKL5_Spur --------I AqueK106_Aque EELLDHPVF AqueK107_Aque TQLLKHELF GK026_Glam TQCLDHEFF :