CLUSTAL W (1.83) multiple sequence alignment Doa_Dmel ------------------------------------------------------------ CLK4_Mmus ------------------------------------------------------------ CLK3_Mmus ------------------------------------------------------------ CLK2_Mmus ------------------------------------------------------------ CLK1_Mmus ------------------------------------------------------------ E02H4.3_Cele ------------------------------------------------------------ C16A11.3_Cele ------------------------------------------------------------ KNS1_Scer ------------------------------------------------------------ CLK4_Hsap ------------------------------------------------------------ CLK3_Hsap ------------------------------------------------------------ CLK2_Hsap ------------------------------------------------------------ CLK1_Hsap ------------------------------------------------------------ Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis ------------------------------------------------------------ 22369_Tthe KDRTKNYREYRGSISKKYKNNQSGNYSKFQNRQNSRSRSRSQQQRNAPAQYQNSFQNNEK CLK_Spur ------------------------------------------------------------ CC1G_01467_Ccin ------------------------------------------------------------ CC1G_10232_Ccin ------------------------------------------------------------ CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin ------------------------------------------------------------ AqueK109_Aque ------------------------------------------------------------ CLK_a_Smoe ------------------------------------------------------------ CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel ------------------------------------------------------------ CLK4_Mmus ------------------------------------------------------------ CLK3_Mmus ------------------------------------------------------------ CLK2_Mmus ------------------------------------------------------------ CLK1_Mmus ------------------------------------------------------------ E02H4.3_Cele ------------------------------------------------------------ C16A11.3_Cele ------------------------------------------------------------ KNS1_Scer ------------------------------------------------------------ CLK4_Hsap ------------------------------------------------------------ CLK3_Hsap ------------------------------------------------------------ CLK2_Hsap ------------------------------------------------------------ CLK1_Hsap ------------------------------------------------------------ Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis ------------------------------------------------------------ 22369_Tthe LRYDNNNNRYQQNQYSQNDRDFRGGSVERRYDQGPNNQYSRNEGRDNNNFGRNNYKNDTG CLK_Spur ------------------------------------------------------------ CC1G_01467_Ccin ------------------------------------------------------------ CC1G_10232_Ccin ------------------------------------------------------------ CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin ------------------------------------------------------------ AqueK109_Aque ------------------------------------------------------------ CLK_a_Smoe ------------------------------------------------------------ CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel ------------------------------------------------------------ CLK4_Mmus ------------------------------------------------------------ CLK3_Mmus ------------------------------------------------------------ CLK2_Mmus ------------------------------------------------------------ CLK1_Mmus ------------------------------------------------------------ E02H4.3_Cele ------------------------------------------------------------ C16A11.3_Cele ------------------------------------------------------------ KNS1_Scer ------------------------------------------------------------ CLK4_Hsap ------------------------------------------------------------ CLK3_Hsap ------------------------------------------------------------ CLK2_Hsap ------------------------------------------------------------ CLK1_Hsap ------------------------------------------------------------ Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis ------------------------------------------------------------ 22369_Tthe YSRGGRDYSPQRSNGVDSRRKSLSQKNQRYYSQNQYSQGGNQAQSYPYQQNSFNQAQQSH CLK_Spur ------------------------------------------------------------ CC1G_01467_Ccin ------------------------------------------------------------ CC1G_10232_Ccin ------------------------------------------------------------ CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin ------------------------------------------------------------ AqueK109_Aque ------------------------------------------------------------ CLK_a_Smoe ------------------------------------------------------------ CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel ------------------------------------------------------------ CLK4_Mmus ------------------------------------------------------------ CLK3_Mmus ------------------------------------------------------------ CLK2_Mmus ------------------------------------------------------------ CLK1_Mmus ------------------------------------------------------------ E02H4.3_Cele ------------------------------------------------------------ C16A11.3_Cele ------------------------------------------------------------ KNS1_Scer ------------------------------------------------------------ CLK4_Hsap ------------------------------------------------------------ CLK3_Hsap ------------------------------------------------------------ CLK2_Hsap ------------------------------------------------------------ CLK1_Hsap ------------------------------------------------------------ Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis ------------------------------------------------------------ 22369_Tthe YGNSYPNHQQSSYNNNNNNSNSNYKKENVEDYYKNRDYKDWNNRDGNRNDRQNNNYSSNN CLK_Spur ------------------------------------------------------------ CC1G_01467_Ccin ------------------------------------------------------------ CC1G_10232_Ccin ------------------------------------------------------------ CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin ------------------------------------------------------------ AqueK109_Aque ------------------------------------------------------------ CLK_a_Smoe ------------------------------------------------------------ CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel ------------------------------------------------------------ CLK4_Mmus ------------------------------------------------------------ CLK3_Mmus ------------------------------------------------------------ CLK2_Mmus ------------------------------------------------------------ CLK1_Mmus ------------------------------------------------------------ E02H4.3_Cele ------------------------------------------------------------ C16A11.3_Cele ------------------------------------------------------------ KNS1_Scer ------------------------------------------------------------ CLK4_Hsap ------------------------------------------------------------ CLK3_Hsap ------------------------------------------------------------ CLK2_Hsap ------------------------------------------------------------ CLK1_Hsap ------------------------------------------------------------ Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis ------------------------------------------------------------ 22369_Tthe NGNHNNSNNSRFTNNPSGHSTINNSNNSYDKRNESYRQANTFPSDQYSRGNGSGNGNQNS CLK_Spur ------------------------------------------------------------ CC1G_01467_Ccin ------------------------------------------------------------ CC1G_10232_Ccin ------------------------------------------------------------ CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin ------------------------------------------------------------ AqueK109_Aque ------------------------------------------------------------ CLK_a_Smoe ------------------------------------------------------------ CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel ------------------------------------------------------------ CLK4_Mmus ------------------------------------------------------------ CLK3_Mmus ------------------------------------------------------------ CLK2_Mmus ------------------------------------------------------------ CLK1_Mmus ------------------------------------------------------------ E02H4.3_Cele ------------------------------------------------------------ C16A11.3_Cele ------------------------------------------------------------ KNS1_Scer ------------------------------------------------------------ CLK4_Hsap ------------------------------------------------------------ CLK3_Hsap ------------------------------------------------------------ CLK2_Hsap ------------------------------------------------------------ CLK1_Hsap ------------------------------------------------------------ Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis ------------------------------------------------------------ 22369_Tthe FNKNDNNSNYNSYNGNRSYKNEYQNSSQGHKQYGNNNNNYDNKRVSSQNYRNLTGGGGSY CLK_Spur ------------------------------------------------------------ CC1G_01467_Ccin ------------------------------------------------------------ CC1G_10232_Ccin ------------------------------------------------------------ CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin ------------------------------------------------------------ AqueK109_Aque ------------------------------------------------------------ CLK_a_Smoe ------------------------------------------------------------ CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel ------------------------------------------------------------ CLK4_Mmus ------------------------------------------------------------ CLK3_Mmus ------------------------------------------------------------ CLK2_Mmus ------------------------------------------------------------ CLK1_Mmus ------------------------------------------------------------ E02H4.3_Cele ------------------------------------------------------------ C16A11.3_Cele ------------------------------------------------------------ KNS1_Scer ------------------------------------------------------------ CLK4_Hsap ------------------------------------------------------------ CLK3_Hsap ------------------------------------------------------------ CLK2_Hsap ------------------------------------------------------------ CLK1_Hsap ------------------------------------------------------------ Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis ------------------------------------------------------------ 22369_Tthe NNNGNFRRSNSNRNRSNNNYKNYGRDNNNFRRNNSPRRNYNRYDNRNYERRDSQSRRTDK CLK_Spur ------------------------------------------------------------ CC1G_01467_Ccin ------------------------------------------------------------ CC1G_10232_Ccin ------------------------------------------------------------ CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin ------------------------------------------------------------ AqueK109_Aque ------------------------------------------------------------ CLK_a_Smoe ------------------------------------------------------------ CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel ------------------------------------------------------------ CLK4_Mmus ------------------------------------------------------------ CLK3_Mmus ------------------------------------------------------------ CLK2_Mmus ------------------------------------------------------------ CLK1_Mmus ------------------------------------------------------------ E02H4.3_Cele ------------------------------------------------------------ C16A11.3_Cele ------------------------------------------------------------ KNS1_Scer ------------------------------------------------------------ CLK4_Hsap ------------------------------------------------------------ CLK3_Hsap ------------------------------------------------------------ CLK2_Hsap ------------------------------------------------------------ CLK1_Hsap ------------------------------------------------------------ Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis ------------------------------------------------------------ 22369_Tthe YQNLDRKYHHSDRSNKFQKANKSYYNSNRSNSIKYKGQKDNQYNRQGYQQSDGTSKKYYK CLK_Spur ------------------------------------------------------------ CC1G_01467_Ccin ------------------------------------------------------------ CC1G_10232_Ccin ------------------------------------------------------------ CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin ------------------------------------------------------------ AqueK109_Aque ------------------------------------------------------------ CLK_a_Smoe ------------------------------------------------------------ CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel ------------------------------------------------YKIMATLGEGTF CLK4_Mmus ------------------------------------------------YEIVDTLGEGAF CLK3_Mmus ------------------------------------------------YEIVGNLGEGTF CLK2_Mmus ------------------------------------------------YEIVSTLGEGTF CLK1_Mmus ------------------------------------------------YEIVDTLGEGAF E02H4.3_Cele ------------------------------------------------FTIYDTLGEGTF C16A11.3_Cele ------------------------------------------------LKIIAKLGEGVF KNS1_Scer ------------------------------------------------FVVKDLLGQGTF CLK4_Hsap ------------------------------------------------YEIVDTLGEGAF CLK3_Hsap ------------------------------------------------YEIVGNLGEGTF CLK2_Hsap ------------------------------------------------YEIVSTLGEGTF CLK1_Hsap ------------------------------------------------YEIVDTLGEGAF Y111B2A.1_Cele ------------------------------------------------LENVSVLGEGVF ClkA_Ddis ------------------------------------------------YKVLCTVGSGTF 22369_Tthe DNKSKQTHSSSSKSSSSKDSFVSGASKDRSKDAGHYKFKNGETFDDGRYVVVKHLSDGTF CLK_Spur ------------------------------------------------YAITSTLGEGTF CC1G_01467_Ccin ------------------------------------------------------------ CC1G_10232_Ccin ------------------------------------------------------------ CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin ------------------------------------------------YRTVRLLGQGTF AqueK109_Aque ------------------------------------------------YEVLRTLGEGTF CLK_a_Smoe ------------------------------------------------YKIIGKMGEGTF CLK_d_Smoe ------------------------------------------------YKVISKMGEGTF CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------YKIIGKMGEGTF GK028_Glam ------------------------------------------------YAIFARLGHGTF Doa_Dmel GRVVKVKDMER-DYCMALKIIKNVEK------Y-REAAKL---EINALEKIA-------Q CLK4_Mmus GKVVECIDHGMDGLHVAVKIVKNVGR------Y-REAARS---EIQVLEHLN-------S CLK3_Mmus GKVVECLDHARGKSQVALKIIRNVGK------Y-REAARL---EINVLKKIK-------E CLK2_Mmus GRVVQCVDHRRGGTQVALKIIKNVEK------Y-KEAARL---EINVLEKIN-------E CLK1_Mmus GKVVECIDHKVGGRRVAVKIVKNVDR------Y-CEAAQS---EIQVLEHLN-------T E02H4.3_Cele GKVVRVNDSLS-DTFMALKIIKNVSK------Y-REAAKL---EVKVLQKLA-------E C16A11.3_Cele GAVYKVVDHSN--KKYAVKLFKEEHSEV-----GEQSWAR---ETAIMKAVT-------A KNS1_Scer GKVLKCIDNKYEPNYVAVKVIRAVDR------Y-REAAKT---ELRILQTIL-------N CLK4_Hsap GKVVECIDHGMDGMHVAVKIVKNVGR------Y-REAARS---EIQVLEHLN-------S CLK3_Hsap GKVVECLDHARGKSQVALKIIRNVGK------Y-REAARL---EINVLKKIK-------E CLK2_Hsap GRVVQCVDHRRGGARVALKIIKNVEK------Y-KEAARL---EINVLEKIN-------E CLK1_Hsap GKVVECIDHKAGGRHVAVKIVKNVDR------Y-CEAARS---EIQVLEHLN-------T Y111B2A.1_Cele GTVFEVADAEK-KKKFALKLFKAGHTQFGCEDWVRESELSIPNYLQIMKSVA-------A ClkA_Ddis STVVECWDTNS-SGQVAIKIVRSAKK------Y-TEDALV---EIDILRNLE-------K 22369_Tthe GRVLEVQDRQNGNKLYALKVIRAVER------Y-VDAAQI---ETEIIRKIQ-------A CLK_Spur GKVVQCRDNMSGGAKIALKIIKNIEK------Y-REAAKL---EINVLEKIN-------E CC1G_01467_Ccin -------DMRS-RERVVVKAIALAD-----------DSEH---EVTRLQRLTRCLDHAK- CC1G_10232_Ccin ------------------------------------------------------------ CC1G_15475_Ccin ----------------IIKAIATGT-----------DERF---ERKRIRRLTNALDRAAN CC1G_06417_Ccin GKVVEAIDTQT-NNRVAIKIIRAIPK------Y-RDASKI---EVRVLQKLK-------E AqueK109_Aque GKVVCCHDRLT-GKDVAVKIIKNVPK------Y-RAAARI---EIRVLEQIR-------D CLK_a_Smoe GRVLECWDRDT-QEYVAIKLIRNVQK------Y-RDAAMI---EIDVLNELA-------R CLK_d_Smoe GRVLECWDRKY-QEFVAVKVIRNVPK------Y-REAALI---EIDVLRALR-------K CLK_b_Smoe ---------------VAIKVIRNVPK------Y-REATLI---EIDVLKALQ-------K CLK_c_Smoe GRVLECWDRDT-QEYVAIKLIRNVQK------Y-RDAAMI---EIDVLNELA-------R GK028_Glam GRVYACYDKSRDDTEVAVKVIRAIDR------Y-TAAGKA---EEAVLNKIK-------Q Doa_Dmel KDP-HCD---------------------HLCVKM--I-DWFDYHGHMCIVFEMLGLSVFD CLK4_Mmus TDP-NSV---------------------FRCVQM--L-EWFDHHGHVCIVFELLGLSTYD CLK3_Mmus KDK-ENK---------------------FLCVLM--S-DWFNFHGHMCIAFELLGKNTFE CLK2_Mmus KDP-DNK---------------------NLCVQM--F-DWFDYHGHMCISFELLGLSTFD CLK1_Mmus TDP-HST---------------------FRCVQM--L-EWFEHRGHICIVFELLGLSTYD E02H4.3_Cele KDP-EKK---------------------NWVIHM--G-SYFDYNGHICLLFDLMGSSIFD C16A11.3_Cele INSA-NLIRM------------------EDSWRI--NESVPNGFLKIAISFELKGRSVFE KNS1_Scer NDP-QGQ---------------------FQCLLL--R-ECFDYKNHICLVTDLYGRSIYD CLK4_Hsap TDP-NSV---------------------FRCVQM--L-EWFDHHGHVCIVFELLGLSTYD CLK3_Hsap KDK-ENK---------------------FLCVLM--S-DWFNFHGHMCIAFELLGKNTFE CLK2_Hsap KDP-DNK---------------------NLCVQM--F-DWFDYHGHMCISFELLGLSTFD CLK1_Hsap TDP-NST---------------------FRCVQM--L-EWFEHHGHICIVFELLGLSTYD Y111B2A.1_Cele AHHP-NLIKL------------------VKSGKM--A-SVPEGYLRIAILMELRGKSLFS ClkA_Ddis TGNSNGKY-L------------------SHCIRL--L-DSFLFKDHICLVFKRYGLSLYE 22369_Tthe ADP-ENK---------------------YRIVKL--E-STFKHGANFCMIFEKLGLSLYE CLK_Spur KEG-VGK---------------------SLCVKM--Y-DWFDYHGHVCISFEILGLSIFD CC1G_01467_Ccin ---AKGLT---------------------LFVDILAS-EVTNVYSVVCL--TAHGMSLRD CC1G_10232_Ccin ------------------------------------------------LVFEDEGVPLSS CC1G_15475_Ccin MF-PHVQ----------------------SLATL--M-DYEVHPSHTFLVFKAYGKTLTE CC1G_06417_Ccin RDP-LNR---------------------NKCIHL--L-HWFDHRNHICLVSELLGMCVYD AqueK109_Aque IVE-DGQ---------------------ELCVQL--R-DWFDYYGHISLTFDMLGLSVFD CLK_a_Smoe YDR-NGS---------------------RRCVQL--K-RWFDFRNHICMVFEKLGPSLYD CLK_d_Smoe HDK-NGK---------------------RGCLQM--K-EWFDYRNHVCIVSEKLGPSLYD CLK_b_Smoe HDK-NGK---------------------RGCLQM--K-EWFDYRNHVCIVSEKLGPSLYD CLK_c_Smoe YDR-NGS---------------------RRCVQL--K-RWFDFRNHICMVFEKLGPSLYD GK028_Glam AAK-KAQH-TGYSSSLMNSYYAKLCWNNCNLAYL--E-RSFQHNNHICLVFPKYGISLLD : * . Doa_Dmel FLRE-------NNYEPYPLDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTS CLK4_Mmus FIKE-------NSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVV CLK3_Mmus FLKE-------NNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFET CLK2_Mmus FLKD-------NNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYEL CLK1_Mmus FIKE-------NSFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDYTE E02H4.3_Cele FLKA-------NHYKPYPMEQTLHITWQLCNAVKFLHDNKLTHTDLKPENILFVDSRYTT C16A11.3_Cele VMDSTKGKMPAGSEISFEINAIRVMGKQLLEAMEKLESVKIVHLDLKPENICFSSSCTFK KNS1_Scer FMCS-------NGIARFPGSHIQAIARQLIRSVCFLHDLGIIHTDLKPENILICDETHIA CLK4_Hsap FIKE-------NSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVV CLK3_Hsap FLKE-------NNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFET CLK2_Hsap FLKD-------NNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYEL CLK1_Hsap FIKE-------NGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTE Y111B2A.1_Cele VMDSTKSE-VPNKEISFPIATIREIGAQILSAMKKLEKMEIVHLDLKPENICFTSTCTFT ClkA_Ddis FLKK-------NRYRPLPLSQIQNISKQLLTAIYSMHKLSLVHTDLKPENILLESSRFTY 22369_Tthe LLKK-------NNYIGYKIRLVQSFFKQILESVGFLHSIHLTHTDLKPENILLASPELRL CLK_Spur FLKD-------NNYQPYPLDQIKRMSHQLCSAVKFLHDMKITHTDLKPENILFVDSRSSI CC1G_01467_Ccin VLDI-------KELVPLPLNQVKAFSHQILSGIQYLHTQDIIHTDITPSNVVLVQDDITC CC1G_10232_Ccin IIRN-------NNIATFSPRQVREIVWQTANALDFLHSHGITHGDLCPSNIKLSSIATVQ CC1G_15475_Ccin VMTM-------QQLLPLPSSQIKGIAFQILSALRFLHGEDIAHTDIKPDNIVLVDDAVAS CC1G_06417_Ccin FLKE-------NDFAPFPRHHIQDFARQLFGSVAFLHELRLIHTDLKPENILLVHNDYRT AqueK109_Aque FLKD-------NNYHPYSLSQVRHISWQLIKAVRYLHQTRLTHTDLKPENILFVSSDYDM CLK_a_Smoe FLRK-------NEYRPYAIDLVREFGRQLLESVAYMHDLTLIHTDLKPENILLVSPDHVK CLK_d_Smoe FLKK-------NSYRPFSIEHVRDIGWQLLNSVAYLHELSLIHTDLKPENILLVSSAYVK CLK_b_Smoe FLKK-------NSYRPFSIE---HVGWQLLNSVAYLHELSLIHTDLKPENILLVSSAYVK CLK_c_Smoe FLRK-------NEYRPYAIDLVREFGRQLLESVAYMHDLTLIHTDLKPENILLVSPDHVK GK028_Glam LLKA-------NNFRGFNIDWTRELSRSFMVGVGFLHDLGYIHTDIKLENILSREKPRAT .: . . .: :. * *: .*: Doa_Dmel H-Y-NHKIN--------------------------------------------------- CLK4_Mmus K-Y-NSKMK--------------------------------------------------- CLK3_Mmus L-Y-NEHKS--------------------------------------------------- CLK2_Mmus T-Y-NLEKK--------------------------------------------------- CLK1_Mmus A-Y-NPKMK--------------------------------------------------- E02H4.3_Cele K-L-VDKKVGKFVLRRF--KI--------------------DDC-F-------------- C16A11.3_Cele T-T----VT--------------------------------------------------- KNS1_Scer Q-KLPLKT-VQSL----------------------------------------------- CLK4_Hsap K-Y-NSKMK--------------------------------------------------- CLK3_Hsap L-Y-NEHKS--------------------------------------------------- CLK2_Hsap T-Y-NLEKK--------------------------------------------------- CLK1_Hsap A-Y-NPKIK--------------------------------------------------- Y111B2A.1_Cele T-E----IR--------------------------------------------------- ClkA_Ddis F-D-NSIP-LQFK-NSI------------------------------------------- 22369_Tthe V-V-ENNSQ-KDS-PSTQYQSSDKTNATAGTVSENNQKNEHQNNSTGKRSSSSSSSSSSS CLK_Spur K-Y-DPVKK--------------------------------------------------- CC1G_01467_Ccin Y-Q-EYTAT--------------------------------------------------- CC1G_10232_Ccin EVYFDW-ES--------------------------------------------------- CC1G_15475_Ccin Y-E-DFQNG--------------------------------------------------- CC1G_06417_Ccin I-NVPIPG---------------------------------------------------- AqueK109_Aque Y-Y-DARKK--------------------------------------------------- CLK_a_Smoe V-P-DFKG-LY------------------------------------------------- CLK_d_Smoe T-L-DYKV-AHFV-RSF--LV--------------------LLT-L-------------- CLK_b_Smoe T-L-DYKV-VHFV-RSF--LV--------------------ILT-L-------------- CLK_c_Smoe V-P-DFKG-LY------------------------------------------------- GK028_Glam R-V--------------------------------------------------------- Doa_Dmel ---------------REVRRVKNTDVRLIDFGSATFDH---E-HHSTIVSTRHYRAPEVI CLK4_Mmus ---------------RDERTLKNTDIKVVDFGSATYDD---E-HHSTLVSTRHYRAPEVI CLK3_Mmus ---------------CEEKSVKNTSIRVADFGSATFDH---E-HHTTIVATRHYRPPEVI CLK2_Mmus ---------------RDERSVKSTAVRVVDFGSATFDH---E-HHSTIVSTRHYRAPEVI CLK1_Mmus ---------------RDERTIVNPDIKVVDFGSATYDD---E-HHSTLVSTRHYRAPEVI E02H4.3_Cele ---------------QPLRVLHSTHVRLIDFGSATFDH---E-HHSIIVSTRHYRAPEVI C16A11.3_Cele ------------GNVCFIQ-PSIFHVCVVDFGNARTIRQDKP-PKYALVQTQNYRAPEIF KNS1_Scer ------SKRRREASKGKRKILKNPEIKIIDFGSAIFHY---E-YHPPVISTRHYRAPEIV CLK4_Hsap ---------------RDERTLKNTDIKVVDFGSATYDD---E-HHSTLVSTRHYRAPEVI CLK3_Hsap ---------------CEEKSVKNTSIRVADFGSATFDH---E-HHTTIVATRHYRPPEVI CLK2_Hsap ---------------RDERSVKSTAVRVVDFGSATFDH---E-HHSTIVSTRHYRAPEVI CLK1_Hsap ---------------RDERTLINPDIKVVDFGSATYDD---E-HHSTLVSTRHYRAPEVI Y111B2A.1_Cele ------------KDVCYISPSEELNVCIIDFGNARKSNQEDL-KSSEVVQTQNYRAPEIF ClkA_Ddis -------DTTSNNSVDHYCHLVDTDIVVIDFGGATFEN---T-HHTAIVCSRPYRPPEII 22369_Tthe SSSSGSHAKSSSKNSKKYWVPVSDEIKIIDFGGATFED---E-HHSDIINTRQYRAPEVI CLK_Spur ---------------RDVRQVVNCDIRLIDFGSATFDH---E-HHSTIVSTRHYRALEVI CC1G_01467_Ccin ------------NEVVTKHRLRSIAVKLIDLDG-YFDWRV-QCEPRYAAGTRGYRAPEIS CC1G_10232_Ccin ------------RSFDTRKVLKSTELRVCFFGSLGVD---NR-SRN----HDRFRSPEVV CC1G_15475_Ccin -------------EFVTKYLLKNISVKLVDYDDFTDLHAI-P-RPRHLVGTSIYRPPEVI CC1G_06417_Ccin --------KRNG-ATKPKKILNSTEIRLIDFGSATFES---E-YHSTVVCTRHYRAPEII AqueK109_Aque ---------------QDIRVVKSTDVRLIDFGSATFDD---E-HHSTVVSTRHYRAPEVI CLK_a_Smoe --------QRSGPGRCYVRVPRTSEIKLIDFGSATFNS---H-YHCSVISTRHYRAPEVI CLK_d_Smoe -----FPLQSARPDKHLTRTPTSAEIRLIDFGSATFEN---Q-HHSSIVSTRQYRAPEII CLK_b_Smoe -----FPLQSARLDKHLTRTPTSAEIRLIDFGSATFEN---Q-HHSSIVSTRQYRAPEII CLK_c_Smoe --------QRSGPGRCYVRVPRTSEIKLIDFGSATFNS---H-YHCSVISTRHYRAPEVI GK028_Glam -------------RDRIFVHPSGAELVLIDLGSSVRLSD--H-RRPSLVCTRQYRPPEAY : : .. :*. * Doa_Dmel LEL-GWSQPCDVWSIGCILFELYLGIT-LFQTHDN----REHLAMMERILG-QIPYR-MA CLK4_Mmus LAL-GWSQPCDVWSIGCILIEYYLGFT-VFQTHDS----KEHLAMMERILG-PIPAH-MI CLK3_Mmus LEL-GWAQPCDVWSIGCILFEYYRGFT-LFQTHEN----REHLVMMEKILG-PIPSH-MI CLK2_Mmus LEL-GWSQPCDVWSIGCIIFEYYVGFT-LFQTHDN----REHLAMMERILG-PVPSR-MI CLK1_Mmus LAL-GWSQPCDVWSIGCILIEYYLGFT-VFPTHDS----REHLAMMERILG-PLPKH-MI E02H4.3_Cele LEL-GWSQPCDVWSIGCILYELYTGVT-LFQTHEN----REHLAMMERVLG-DIPLR-MA C16A11.3_Cele LGL-PFSVKSDIWSFGCILSELYTGDL-LFYGNSKSDTEELQFELMQMIVQ-QPPSCAML KNS1_Scer LGL-GWSFPCDIWSIACVLVELVIGES-LYPIHEN----LEHMAMMQRINGTPFPTD-II CLK4_Hsap LAL-GWSQPCDVWSIGCILIEYYLGFT-VFQTHDS----KEHLAMMERILG-PIPQH-MI CLK3_Hsap LEL-GWAQPCDVWSIGCILFEYYRGFT-LFQTHEN----REHLVMMEKILG-PIPSH-MI CLK2_Hsap LEL-GWSQPCDVWSIGCIIFEYYVGFT-LFQTHDN----REHLAMMERILG-PIPSR-MI CLK1_Hsap LAL-GWSQPCDVWSIGCILIEYYLGFT-VFPTHDS----KEHLAMMERILG-PLPKH-MI Y111B2A.1_Cele MGL-PFSTRSDVWSFGCILSELYTGEL-LFYGNDEHDTEQLQ------------------ ClkA_Ddis LGM-GWSYPCDIWGVGCILVELYLGYT-LFDTHNN----VQHLAMMEKVMG-PFPNS-MS 22369_Tthe LGCCKWNEVSDVWSIGCIIMELYSGEL-FFPTHEK----IEHLAMIEKVCG-PIPQW-MA CLK_Spur LEL-GWSQPCDVWSIGCIIFELYTGFT-LFQTHDN----REHLAMAERILG-NFPSW-MI CC1G_01467_Ccin LGI-PWTKGIDIFSFGCTLWELHSGGA-LFNPSDDW---TKQLRIIERFAG-KLSSN-FF CC1G_10232_Ccin AGI-GVDYKTDIFSLGCLMKELIINRPFLYDCMDSMFYVRDKLWVMENILG-SFPQE-LA CC1G_15475_Ccin LNM-PWSTPVDIFAFGCTIAELYLGRP-LFPHSTGP---SHQLAIIEERLG-RFPHS-FI CC1G_06417_Ccin LGL-GWSFPCDAYSLGCILVEFYTGLA-LYQTHDN----LEHLAMMEMVMG-KMPER-FA AqueK109_Aque LEL-GWSHPCDMWSVGCIMFELYRGHT-LFQTHDN----LEHLAMMETILG-PLPVR-FV CLK_a_Smoe LGL-GWSYSCDIWSIGCILVELCSGST-LFQTHEN----LEHLAMMERIIG-PLPAH-MI CLK_d_Smoe LGL-GWSYACDLWSVGCILVELFSGDP-LFQTHEN----LEHLAMMERILG-PISRR-II CLK_b_Smoe LGL-GWSYACDLWSVGCILVELFSGDP-LFQTHEN----LEHLAMMERILG-PIPRR-II CLK_c_Smoe LGL-GWSYSCDIWSIGCILVELCSGST-LFQTHEN----LEHLAMMERIIG-PLPAH-MI GK028_Glam LGL-PFDQTLDIWSCGCVIFEILTGRT-LFRTHNS----VVHLCMMERLLG-PMPDT-VI * :. .* : * . .: : Doa_Dmel RKT-------------KTKYFY-HG-KLDWDE--KSSAGRYVRD---HCKPLF-LC-Q-- CLK4_Mmus QKTR------------KRKYFH-HN-QLDWDE--HSSAGRYVRR---RCKPLK-EF-M-- CLK3_Mmus HRTR------------KQKYFY-KG-GLVWDE--NSSDGRYVKE---NCKPLK-SY-M-- CLK2_Mmus RKTR------------KQKYFY-RG-RLDWDE--NTSAGRYVRE---NCKPLR-RY-L-- CLK1_Mmus QKTR------------KRRYFH-HD-RLDWDE--HSSAGRYVSR---RCKPLK-EF-M-- E02H4.3_Cele KRT-------------KTKFFI-NG-RLDWVN--TSADAAYVRD---NCKPLR-RS-M-- C16A11.3_Cele REAEK---I--K----STKIRI-----ENGNVYMKRKSKS-SF---EPPKPLH-KQ-R-- KNS1_Scer D----------------------------------------------------------- CLK4_Hsap QKTR------------KRKYFH-HN-QLDWDE--HSSAGRYVRR---RCKPLK-EF-M-- CLK3_Hsap HRTR------------KQKYFY-KG-GLVWDE--NSSDGRYVKE---NCKPLK-SY-M-- CLK2_Hsap RKTR------------KQKYFY-RG-RLDWDE--NTSAGRYVRE---NCKPLR-RY-L-- CLK1_Hsap QKTR------------KRKYFH-HD-RLDWDE--HSSAGRYVSR---RCKPLK-EF-M-- Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis NVS-----K---------KYFN-DYGTLNRPQ--NSDEIKSMER-VEGLKQLK-EY-F-- 22369_Tthe QRSDN---SVNSHFKVTEEHFQQNGTYFDWPK--NDTSRKSIS----NVKNLL-SF-D-- CLK_Spur KRTR------------KSKYFY-HD-RVDWNQ--DNSSGRYVCE---NCHPFR-YY-L-- CC1G_01467_Ccin ERLRI---DGSP-------YSK-EDFKLSWRH--AEDRESQ------------------- CC1G_10232_Ccin ETIEA------K----HAGVFT-----PWWRV--ATSSEDHFD---DKIVEFVGDSDT-- CC1G_15475_Ccin DRVNR---GGFN-------VFR-PNGEVDCAE--PVAQHLAVEE-R---KHI-------- CC1G_06417_Ccin RAGAR---S-------KPEFFK-EGAKLDWPK--AKSTRQSKKD-VKSTRPLA-LT-ARQ AqueK109_Aque RESR------------KSKYFW-HG-KLDWDP--ESPDGRYIRE---HCRKLK-RY-I-- CLK_a_Smoe EKADR---R-------AEKYFK-NKVELNWPE--GAVSRESVRA-VRKLPRLR-NM-I-- CLK_d_Smoe DNVDR---K-------AQKYFK-NGRELNWPD--AASSLESIRT-VKRLPRLK-EL-V-- CLK_b_Smoe DNVDR---K-------AQKYFK-NGRELNWPD--AASSLESIRT-VKRLPRLK-EL-V-- CLK_c_Smoe EKADR---R-------AEKYFK-NKVELNWPE--GAVSRESVRA-VRKLPRLR-NM-I-- GK028_Glam EQMDIYNSK-------YQEFFC-RT-KKSWSL--PTDLDPQERRHYEELLPLE-RE-I-- Doa_Dmel --LSD-SEDHCELFSLIKKMLEYEPSSRITLGEALHHPFF CLK4_Mmus --LCH-DEEHEKLFDLVRRMLEYDPARRITLDEALQHPFF CLK3_Mmus --LQD-SLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFF CLK2_Mmus --TSE-AEDHHQLFDLIENMLEYEPAKRLTLGEALQHPFF CLK1_Mmus --LSQ-DAEHELLFDLIGKMLEYDPAKRITLKEALKHPFF E02H4.3_Cele --SCT-DPEHVELFELIENMLMFEPLARMKLPEALQHRYF C16A11.3_Cele --RPK-DLEAIPLFDLLECILIVDPSRRPSLRDISSRTFF KNS1_Scer ---------WYWFIDLLRKMFEFDPTKRITAKDALDHEWF CLK4_Hsap --LCH-DEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF CLK3_Hsap --LQD-SLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFF CLK2_Hsap --TSE-AEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF CLK1_Hsap --LSQ-DVEHERLFDLIQKMLEYDPAKRITLREALKHPFF Y111B2A.1_Cele -------------FELMQLILQQAP--------------S ClkA_Ddis ------HPCHDSFFDLASRLLEYQPSKRISASDALSHP-F 22369_Tthe --DIL-KPEHRILGDLVRKCLIIDPNQRITCAQALQHEFF CLK_Spur --DSN-ADEHRLLFDTIEEMLEFDPFKRATLSQVLDHPYF CC1G_01467_Ccin ---MI-QIRRPDLRDLLKACLQGDDRVRVGVDQALQHRFY CC1G_10232_Ccin --LPE-LIRDRDALEVIRSMTAYRPSDRPSIWVLTSADYF CC1G_15475_Ccin ---SL-CILRPNLLDLLKLCLHHDDKKRCSAKAALQHRFF CC1G_06417_Ccin DVIPPYDHINRQFLNLVQKLLAFDPAQRITVREALAHPYF AqueK109_Aque --LSA-EPEHEHLFDLITQLLTYEPRKRMTASEALKHSFF CLK_a_Smoe --LQHVDQYPNVLLDLLQGLLRYEPTERLSAKQALSHPFF CLK_d_Smoe --QLHVEHSASSLTDLLEGLLRYGASDRLTAKEALRHPFF CLK_b_Smoe --QLHVEHSASSLTDLLEGLLRYGASDRLTAKEALRHPFF CLK_c_Smoe --LQHVDQYPNVLLDLLQGLLRYEPTERLSAKQALSHPFF GK028_Glam --DKYGYGYHTSLIHLLRVMLSWDARKRFSVPECMAHPFF