CLUSTAL W (1.83) multiple sequence alignment ROCK2_Hsap_ROCK YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA---N ROCK1_Hsap_ROCK YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA---N MRCKb_Hsap_GEK FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNG---D MRCKa_Hsap_GEK FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNG---D CG10522_Dmel_CRIK FLIKTLIGQGYFGNVHLVVERQTNDIYAMKKIKKSVV----TTSQVKEERDIMSIR---N rok_Dmel_ROCK FHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHA---N gek_Dmel_GEK FDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFG---D MRCKb_Mmus_GEK FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNG---D MRCKa_Mmus_GEK FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNG---D DMPK2_Mmus_GEK FEILKVIGRGAFGEVAVVRQRGSGQIFAMKMLHKWEMLKRAETACFREERDVLVKG---D DMPK1_Mmus_GEK FEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVKG---D CRIK_Mmus_CRIK FEVRSLVGCGHFAEVQVVREKATGDVYAMKIMKKKALLAQEQVSFFEEERNILSRS---T let-502_Cele_ROCK FRQLKVIGRGAFGEVHLVRHTRTNTVYAMKMLNKDDMIKRADSAFFWEERDIMAHA---N K08B12.5_Cele_GEK FEVLKVIGKGAFGEVAVVRMRGVGEIYAMKILNKWEMVKRAETACFREERDVLVYG---D DMPK2_Hsap_GEK FEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKG---D DMPK1_Hsap_GEK FEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNG---D CRIK_Hsap_CRIK FEVRSLVGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRS---T ROCK1_Mmus_ROCK YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA---N ROCK2_Mmus_ROCK YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA---N MRCK_Spur_GEK FETLKIIGRGAFGEVAVVKLKNSDDVFAMKLLNKWEMLKRAETACFVEERDVLVHG---D ROCK_Spur_ROCK FQMIKVIGRGAFGEVKVVRERTSKKVYAMKCLSKFEMIKRSDSAFYWEERDIMAHA---N CRIK_Spur_CRIK FEVKDVIGRGHFGQVQVVREKVTNDVYAMKVLHKAETLAKENVAFFEEEKDIMARA---S CC1G_07309_Ccin_GEK LQVVGTLEYGQFGVIEVVTCKLNNRVYVRKSIEKKFAMRTREQCSPQTERNILVAASLTE AqueK004_Aque_CRIK FITKGIIGQGHFGEVRVVQEKTTSQIYAMKIMKKTHILQQADATFFIEERDIMALG---N AqueK005_Aque_GEK FEVLEVIGRGAFGEVKVVRLKSTNKVYALKVLNKAEMLQRQTTACFKEERDVLVFG---N AqueK006_Aque_ROCK FQLIKVIGRGAFGEVHLVRMKETKKIFAMKILSKFEMIRRSDTAFFWEERDIMAHT---T : * *. : :* ::. * : * *:.:: ROCK2_Hsap_ROCK SPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFYTAEVVLALDAIH ROCK1_Hsap_ROCK SPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEVVLALDAIH MRCKb_Hsap_GEK CQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIH MRCKa_Hsap_GEK NKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVH CG10522_Dmel_CRIK SEWLINLQYAFQDNDNLYLVMEYMPGGDLLSLMSRHG-PFDEDLARFYLAELTVALHTLH rok_Dmel_ROCK SEWIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDYD--IPEKWAIFYTMEVVLALDTIH gek_Dmel_GEK RQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPEDMAKFYITEMILAINSIH MRCKb_Mmus_GEK CQWITALHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIH MRCKa_Mmus_GEK SKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSVH DMPK2_Mmus_GEK SRWVTALHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLH DMPK1_Mmus_GEK RRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVH CRIK_Mmus_CRIK SPWIPQLQYAFQDKNNLYLVMEYQPGGDLLSLLNRYEDQLDESMIQFYLAELILAVHSVH let-502_Cele_ROCK SEWIVRLQYAFQDPRHLYMVMEYMPGGDLVNLMTSYE--VSEKWTRFYTAEIVEALAALH K08B12.5_Cele_GEK RRWITNLHYAFQDEKNLYFVMDYYIGGDMLTLLSKFVDHIPESMAKFYIAEMVLAIDSLH DMPK2_Hsap_GEK SRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLH DMPK1_Hsap_GEK RRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVH CRIK_Hsap_CRIK SPWIPQLQYAFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVH ROCK1_Mmus_ROCK SPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEVVLALDAIH ROCK2_Mmus_ROCK SPWVVQLFCAFQDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFYTAEVVLALDAIH MRCK_Spur_GEK SRWITNLHYAFQDDDFLYLVMDYYSGGDLLTLISKFDDRLPEDMARFYVAEMVLAIDSVH ROCK_Spur_ROCK SEWIVQLHYAFQDEKYLYMVMDYMPGGDLVNLMSNYE--IPEKWARFYTAEVVLALDAIH CRIK_Spur_CRIK SPWLTKLQYAFQDDDNLYLMMEFHPGGDLLSLLARFDDVFEENMARFYLAELVAAIHSLH CC1G_07309_Ccin_GEK SPWAPHLLAAYQMPTHLHLVMDYAEGGNLWDVLESSTGKISESDLKWWVPQAVSAIHWCH AqueK004_Aque_CRIK SQWLTKLHYAFQDEKCLYLVMDYHPGGDLFTVMERKEMGMTEGEACFYTAEIICALHDLH AqueK005_Aque_GEK RDWITKLHYAFQDKNNLYFVMDYYLGGDVLTLLSKFEDRLTEDMVKFYASEMILAIHSIH AqueK006_Aque_ROCK SEWIVQ----------------------------RYE--IPEEWAQFYIAELVLALEAVH * . :: : *: * ROCK2_Hsap_ROCK SMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMV--------HCDTAVGTPDYIS ROCK1_Hsap_ROCK SMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMV--------RCDTAVGTPDYIS MRCKb_Hsap_GEK QLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTV--------QSSVAVGTPDYIS MRCKa_Hsap_GEK QLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTV--------QSSVAVGTPDYIS CG10522_Dmel_CRIK EMGYVHRDIKPENILIDRFGHIKLADFGNAAALDRDGHV--------LSLSPVGTPDYIA rok_Dmel_ROCK NMGFVHRDVKPDNMLLDSYGHLKLADFGTCMRMGANGQV--------VSSNAVGTPDYIS gek_Dmel_GEK QIRYVHRDIKPDNVLLDKRGHVRLADFGSCLRLDKDGTV--------QSNVAVGTPDYIS MRCKb_Mmus_GEK QLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTV--------QSSVAVGTPDYIS MRCKa_Mmus_GEK QLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTV--------QSSVAVGTPDYIS DMPK2_Mmus_GEK QLGYVHRDVKPDNILLDMNGHIRLADFGSCLRLNNNGMV--------DSSVAVGTPDYIS DMPK1_Mmus_GEK RLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLQPDGMV--------RSLVAVGTPDYLS CRIK_Mmus_CRIK QMGYVHRDIKPENILIDRTGHIKLVDFGSAAKMNSN-KV--------DAKLPIGTPDYMA let-502_Cele_ROCK SMGYIHRDVKPDNMLISISGHIKLADFGTCVKMNANGVV--------RCSTAVGTPDYIS K08B12.5_Cele_GEK RLGYVHRDVKPDNVLLDMQGHIRLADFGSCLRILADGSV--------ASNVAVGTPDYIS DMPK2_Hsap_GEK QLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMV--------DSSVAVGTPDYIS DMPK1_Hsap_GEK RLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTV--------RSLVAVGTPDYLS CRIK_Hsap_CRIK LMGYVHRDIKPENILVDRTGHIKLVDFGSAAKMNSNKMV--------NAKLPIGTPDYMA ROCK1_Mmus_ROCK SMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMV--------RCDTAVGTPDYIS ROCK2_Mmus_ROCK SMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMV--------HCDTAVGTPDYIS MRCK_Spur_GEK MLRYVHRDIKPDNVLLDKHGHIRLADFGSCLRMLPDNTV--------MSNVAVGTPDYIS ROCK_Spur_ROCK SMGFIHRDVKPDNMLLDSSGHLKLADFGTCMRMERDGMV--------RSDTAVGTPDYIS CRIK_Spur_CRIK TMGYVHRDIKPDNVLLDRTGHIKLADFGSAAKLGDKNTV--------SSKMPVGTPDYVA CC1G_07309_Ccin_GEK TQGFAHRDIKPHNFVLTKDSRVQLIDFGSAAPLLPPGPDGSQKLARKHCLVPCGTCDYIS AqueK004_Aque_CRIK QLGFVHRDVKPDNVLITRSGHIKLVDFGSASRLDENGKV-------VDYTLPVGTPEYIS AqueK005_Aque_GEK DLGYVHRDIKPDNVLIGKDGHIRLADFGSCLKMDSNRKV--------NSTTAVGTPDYIS AqueK006_Aque_ROCK SMGYVHRDVKPENMLLDGRGHLKLADFGTCMKVDKNGKV--------RCETAVGTPDYIS ***:**.*.:: .:::* ***.. : . ** :*:: ROCK2_Hsap_ROCK PEVLKSQ-G-------------------GDGFYGRECDWWSVGVFLYEMLVGDTPFYADS ROCK1_Hsap_ROCK PEVLKSQ-G-------------------GDGYYGRECDWWSVGVFLYEMLVGDTPFYADS MRCKb_Hsap_GEK PEILQAMED-------------------GMGKYGPECDWWSLGVCMYEMLYGETPFYAES MRCKa_Hsap_GEK PEILQAMED-------------------GKGRYGPECDWWSLGVCMYEMLYGETPFYAES CG10522_Dmel_CRIK PELLQTISTY----------------KLSKSMHDVSCDYWSMGIIGYELICETTPFHEDN rok_Dmel_ROCK PEVLQSQ-G-------------------VDNEYGRECDWWSVGIFLYEMLFGETPFYADS gek_Dmel_GEK PEILRAMED-------------------GKGRYGTECDWWSLGVCMYEMLYGETPFYAES MRCKb_Mmus_GEK PEILQAMED-------------------GMGKYGPECDWWSLGVCMYEMLYGETPFYAES MRCKa_Mmus_GEK PEILQAMED-------------------GKGRYGPECDWWSLGVCMYEMLYGETPFYAES DMPK2_Mmus_GEK PEILQAMEE-------------------GKGHYGPQCDWWSLGVCAYELLFGETPFYAES DMPK1_Mmus_GEK PEILQAVGGG-----------------PGAGSYGPECDWWALGVFAYEMFYGQTPFYADS CRIK_Mmus_CRIK PEVLTVMNE------------------DRRGTYGLDCDWWSVGVVAYEMVYGKTPFTEGT let-502_Cele_ROCK PEVLRNQ-G-------------------QDAEFGKEVDWWSVGVFIYEMLVGETPFYAEA K08B12.5_Cele_GEK PEILRAMED-------------------GRGRYGKECDWWSLGICMYEMLYGTTPFYSER DMPK2_Hsap_GEK PEILQAMEE-------------------GKGHYGPQCDWWSLGVCAYELLFGETPFYAES DMPK1_Hsap_GEK PEILQAVGGG-----------------PGTGSYGPECDWWALGVFAYEMFYGQTPFYADS CRIK_Hsap_CRIK PEVLTVMNG------------------DGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGT ROCK1_Mmus_ROCK PEVLKSQ-G-------------------GDGYYGRECDWWSVGVFLYEMLVGDTPFYADS ROCK2_Mmus_ROCK PEVLKSQ-G-------------------GDGYYGRECDWWSVGVFLFEMLVGDTPFYADS MRCK_Spur_GEK PEILRAMED-------------------GKGRYGPECDWWSLGVCMYEMLFGETPFYAES ROCK_Spur_ROCK PEVLKSQ-A-------------------GNGQYGRECDWWSVGVFIYEMLVGDTPFYADS CRIK_Spur_CRIK PEVLQSLN-------------------GSLASYGTECDWWSLGIVAYEMMVGKTPFSDDS CC1G_07309_Ccin_GEK PEILEAHEQALVALEMDDEDENPLVIEDP-EGYGVETDWWSLGAMLYEMAYGVAPFFANE AqueK004_Aque_CRIK PEVLTSL-D-------------------KKLTYGVSCDWWSVGIIMYELLFEVTPFEGST AqueK005_Aque_GEK PEILQAMED-------------------GRGVYGPECDWWSLGICIYEMLFGETPFYAES AqueK006_Aque_ROCK PEVLKSQ-G-------------------GDGYYGKECDWWSVGVVMFEMLCGDLPFYSDS **:* .. . *:*::* :*: ** ROCK2_Hsap_ROCK LVGTYSKIMDH------KNSLCFPEDA----EISKHAKNLICAFLTDREVRLGRNGVEEI ROCK1_Hsap_ROCK LVGTYSKIMNH------KNSLTFPDDN----DISKEAKNLICAFLTDREVRLGRNGVEEI MRCKb_Hsap_GEK LVETYGKIMNH------EERFQFPSHVT---DVSEEAKDLIQRLICSRERRLGQNGIEDF MRCKa_Hsap_GEK LVETYGKIMNH------KERFQFPAQVT---DVSENAKDLIRRLICSREHRLGQNGIEDF CG10522_Dmel_CRIK VHETYSKILSHCEESHLKELISFPADL----KVSVNYRNLIESLVTNPSKRLSY---ERI rok_Dmel_ROCK LVGTYGKIMDH------KNSLSFPPEV----EISEQAKALIRAFLTDRTQRLGRYGIEDI gek_Dmel_GEK LVETYGKIMNH------QNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGIQDF MRCKb_Mmus_GEK LVETYGKIMNH------EERFQFPSHVT---DVSEEAKDLIQRLICSRERRLGQNGIEDF MRCKa_Mmus_GEK LVETYGKIMNH------KERFQFPAQVT---DVSENAKDLIRRLICSREHRLGQNGIEDF DMPK2_Mmus_GEK LVETYGKIMNH------EDHLQFPADVT---DVPASAQDLIRQLLCRQEERLGRGGLDDF DMPK1_Mmus_GEK TAETYAKIVHY------REHLSLPLADT---VVPEEAQDLIRGLLCPAEIRLGRGGAGDF CRIK_Mmus_CRIK SARTFNNIMNF------QRFLKFPDDP----KVSSELLDLLQSLLCVQKERLKF---EGL let-502_Cele_ROCK LVSTYTNIMNH------KTSLKFPDEP----LISTQAKDIIKKFLSAAPDRLGRNSVDDI K08B12.5_Cele_GEK LVDTYGKIMSH------QDMLDFPDDEI-DWVVSEEAKDLIRQLICSSDVRFGRNGLSDF DMPK2_Hsap_GEK LVETYGKIMNH------EDHLQFPPDVP---DVPASAQDLIRQLLCRQEERLGRGGLDDF DMPK1_Hsap_GEK TAETYGKIVHY------KEHLSLPLVDE---GVPEEARDFIQRLLCPPETRLGRGGAGDF CRIK_Hsap_CRIK SARTFNNIMNF------QRFLKFPDDP----KVSSDFLDLIQSLLCGQKERLKF---EGL ROCK1_Mmus_ROCK LVGTYSKIMNH------KNSLTFPDDN----DISKEAKNLICAFLTDREVRLGRNGVEEI ROCK2_Mmus_ROCK LVGTYSKIMDH------KNSLCFPEDT----EISKHAKNLICAFLTDREVRLGRNGVEEI MRCK_Spur_GEK LVETYGKIMNH------KNQFDFPPETEEEVAISEDAKDLILSLICSAEARLGRNGLQDF ROCK_Spur_ROCK LVGTYSKIMDH------RNSLEFPDDI----SISGPAKDLICKFLTDRDTRLGKNGIDEI CRIK_Spur_CRIK MVITYSNIMDF------QRKLSFPTSS----PLTPRATSLIKQLLCDRSARIGY---EQL CC1G_07309_Ccin_GEK IRHTYQRILNH------EKCLRFED------GVSFELQDLLARLLTRAEKRLGRRNIMEI AqueK004_Aque_CRIK TAETYANIMSY------QTSLQIPEE------LSPEARSLIESLLVKPEKRLEY---PDI AqueK005_Aque_GEK LLQTYSKIMQH------KTLFSFPSDED-SIVVSKDAKNLIKNLICDAEERLGQSGIDDF AqueK006_Aque_ROCK LIGTYSNIMNH------KNTLQFT-DV----QLSANAKNIIVHFLEDASNRLGLNGVEEV *: .*: . . : : :. :: :: *: . ROCK2_Hsap_ROCK RQHPFF ROCK1_Hsap_ROCK KRHLFF MRCKb_Hsap_GEK KKHAFF MRCKa_Hsap_GEK KKHPFF CG10522_Dmel_CRIK KNHPFF rok_Dmel_ROCK KAHPFF gek_Dmel_GEK MDHPWF MRCKb_Mmus_GEK KKHAFF MRCKa_Mmus_GEK KKHPFF DMPK2_Mmus_GEK RKHPFF DMPK1_Mmus_GEK QKHPFF CRIK_Mmus_CRIK CCHPFF let-502_Cele_ROCK RNHKFF K08B12.5_Cele_GEK QLHPFF DMPK2_Hsap_GEK RNHPFF DMPK1_Hsap_GEK RTHPFF CRIK_Hsap_CRIK CCHPFF ROCK1_Mmus_ROCK KRHLFF ROCK2_Mmus_ROCK KQHPFF MRCK_Spur_GEK KDHPFF ROCK_Spur_ROCK KLHRFF CRIK_Spur_CRIK GYHEFF CC1G_07309_Ccin_GEK TDHPFF AqueK004_Aque_CRIK VKHPFF AqueK005_Aque_GEK KKHPFF AqueK006_Aque_ROCK KAHPFF * :*