CLUSTAL W (1.83) multiple sequence alignment TBK1_Hsap WLLSDILGQGATANVFRGR----------------------------------------- IKKe_Hsap WHTDDLLGQGATASVYKAR----------------------------------------- IKKb_Hsap WEMKERLGTGGFGNVIRWH----------------------------------------- IKKa_Hsap WEMRERLGTGGFGNVCLYQ----------------------------------------- ird5_Dmel WERCRNLGEGGFGLVIHWR----------------------------------------- ik2_Dmel WCTTSVLGKGATGSVFQGV----------------------------------------- IKKe_Mmus WHTDDLLGQGATASVYKAR----------------------------------------- IKKb_Mmus WEMKERLGTGGFGNVIRWH----------------------------------------- IKKa_Mmus WEMRERLGTGGFGNVSLYQ----------------------------------------- TBK1_Mmus WLLSDILGQGATANVFRGR----------------------------------------- TBK1_Spur WYLKDVLGTGATSSVYLGR----------------------------------------- IKKe_Spur IFLDTPLGQGATSKVYGGR----------------------------------------- IKKa_Spur WQFKKLLGSGSFGEVLLYQLGVGRKVGRFEAESVDWSRCMWSRFGVGEESVRPCCGVWLA AqueK157_Aque NWRRAPIGRGSFGDVSLFT----------------------------------------- AqueK158_Aque WSSKDKLGQGATGQVFAGY----------------------------------------- :* *. . * TBK1_Hsap ------------------------------------------------------------ IKKe_Hsap ------------------------------------------------------------ IKKb_Hsap ------------------------------------------------------------ IKKa_Hsap ------------------------------------------------------------ ird5_Dmel ------------------------------------------------------------ ik2_Dmel ------------------------------------------------------------ IKKe_Mmus ------------------------------------------------------------ IKKb_Mmus ------------------------------------------------------------ IKKa_Mmus ------------------------------------------------------------ TBK1_Mmus ------------------------------------------------------------ TBK1_Spur ------------------------------------------------------------ IKKe_Spur ------------------------------------------------------------ IKKa_Spur SLWCLVGVVVVSGWRRCGVGLVSMSSQFGVDANVGLASMWCHFGLVCGVDEESVCPRCGV AqueK157_Aque ------------------------------------------------------------ AqueK158_Aque ------------------------------------------------------------ TBK1_Hsap -------------------HKKTGDLFAIKVFNNISFLRPV---------DVQMREFEVL IKKe_Hsap -------------------NKKSGELVAVKVFNTTSYLRPR---------EVQVREFEVL IKKb_Hsap -------------------NQETGEQIAIKQCRQELSPRNR---------ERWCLEIQIM IKKa_Hsap -------------------HRELDLKIAIKSCRLELSTKNR---------ERWCHEIQIM ird5_Dmel -------------------NRTTGREIATKHIKEMGALS-ADQQVKL--SERWNKELNWS ik2_Dmel -------------------NKITGESVAVKTFNPYSHMRPA---------DVQMREFEAL IKKe_Mmus -------------------NKKSGEVVAVKVFNSASYRRPP---------EVQVREFEVL IKKb_Mmus -------------------NQATGEQIAIKQCRQELSPKNR---------DRWCLEIQIM IKKa_Mmus -------------------HRELDLKIAIKSCRLELSSKNR---------ERWCHEIQIM TBK1_Mmus -------------------HKKTGDLYAVKVFNNISFLRPV---------DVQMREFEVL TBK1_Spur -------------------HKKNGDVVAVKMFNHLSYMRPR---------DVQQREFEVL IKKe_Spur -------------------HKKLGKRVACKVPHTANLFRMG---------TDMERESQVL IKKa_Spur GLVLMWSQFGVDVVSVRRQCGETSEYIALKRCKSILQLENL---------KRWRDEVEFM AqueK157_Aque --------------------SNDGEQIALKEMKLE-PLRNLDSHERDKMIVRLRNEIKIM AqueK158_Aque -------------------SKRSGDKVAIKMFTSPSEYKAM---------QSEMQTIKAL . * * : TBK1_Hsap KKL-NHKNIVKLFAIEEE-----T----TTRHKVLIMEFCPCGSLYT-VLEEPSNAYGLP IKKe_Hsap RKL-NHQNIVKLFAVEET-----G----GSRQKVLVMEYCSSGSLLS-VLESPENAFGLP IKKb_Hsap RRL-THPNVVAARDVPEG-----MQNLAPNDLPLLAMEYCQGGDLRK-YLNQFENCCGLR IKKa_Hsap KKL-NHANVVKACDVPEE-----LNI-LIHDVPLLAMEYCSGGDLRK-LLNKPENCCGLK ird5_Dmel RQFKNFPHIVAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGGDVRK-RLQSPENANGLT ik2_Dmel KKV-NHENIVKLLAIEED-----Q----EGRGKVIVMELCTGGSLFN-ILDDPENSYGLP IKKe_Mmus RRL-NHQNIVKLFAVEET-----G----GSRQKVLIMEYCSSGSLLS-VLEDPENTFGLS IKKb_Mmus RRL-NHPNVVAARDVPEG-----MQNLAPNDLPLLAMEYCQGGDLRR-YLNQFENCCGLR IKKa_Mmus KKL-DHANVVKACDVPEE-----LNF-LINDVPLLAMEYCSGGDLRK-LLNKPENCCGLK TBK1_Mmus KKL-NHKNIVKLFAIEEE-----T----TTRHKVLIMEFCPCGSLYT-VLEEPSNAYGLP TBK1_Spur LKL-NHKNIIHLDQIEED-----Q----ISKQPVIVMELCTGGSLYT-YLDTPENLYGLK IKKe_Spur LRL-RNQNIVCLEAIEKD-----Q----ISKENILIMELCTGGSLYD-VLEKPENSCGLA IKKa_Spur RNL-EHPNIVQGRPVPPE-----LEA-KPNEPPCLAMEFCSRGDLRK-KLSELPNMCGLP AqueK157_Aque WEH-NHPNLIKALGPPPD-----IPYHPPEDVMHVWMEFCNGGDLRNGVLKKIENCCGVE AqueK158_Aque K---THPNIVSFFELNEI-----E---KKHQYHIIAMELCNGGSLYE-VIDSPQNAYGLD ::: : :* * *.: :. * *: TBK1_Hsap ESEFLIVLRDVVGGMNHLRE-NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD IKKe_Hsap EDEFLVVLRCVVAGMNHLRE-NGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDD IKKb_Hsap EGAILTLLSDIASALRYLHE-NRIIHRDLKPENIVLQQG-EQRLIHKIIDLGYAKELDQG IKKa_Hsap ESQILSLLSDIGSGIRYLHE-NKIIHRDLKPENIVLQDV-GGKIIHKIIDLGYAKDVDQG ird5_Dmel EFEVRQILGALRKALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQ ik2_Dmel EHEFLLVLEHLCAGMKHLRD-NKLVHRDLKPGNIMKFISEDGQTIYKLTDFGAARELEDN IKKe_Mmus EEEFLVVLRCVVAGMNHLRE-NGIVHRDIKPGNIMRLVGEEGQSIYKLSDFGAARKLDDD IKKb_Mmus EGAVLTLLSDIASALRYLHE-NRIIHRDLKPENIVLQQG-EKRLIHKIIDLGYAKELDQG IKKa_Mmus ESQILSLLSDIGSGIRYLHE-NKIIHRDLKPENIVLQDV-GGKTIHKIIDLGYAKDVDQG TBK1_Mmus ESEFLIVLRDVVGGMNHLRE-NGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDD TBK1_Spur EKEFLQVLNDVSAGMKHLRD-KGIVHRDIKPGNIMMVKGEDGVIVYKLADFGAARELEDD IKKe_Spur EKAFLQVLADMTAGMKYLRD-NGVVHRDVKPGNIMCFKDDHGHTIYKLADFGAARQLTDD IKKa_Spur EAEILLLSKHIASAMEYLHK-SDIIHRDIKPENIMVQDW--------------------- AqueK157_Aque EKQFRKICGDINNGIRFLHK-ISVIHRDLKPENILIKHTDANTVVYKLTDFGYAKTYALS AqueK158_Aque EYQFKSVIFDVASGMRHLRD-HGFVHRDIKPGNIMRCINPDGSFVFKLADFGTARQLDPN * . : : .:..*:. . ***:** **: TBK1_Hsap EQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFE-G IKKe_Hsap EKFVSVYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFG-G IKKb_Hsap SLCTSFVGTLQYLAPELLEQ--------QKYTVTVDYWSFGTLAFECITGFRPFLPNW-Q IKKa_Hsap SLCTSFVGTLQYLAPELFEN--------KPYTATVDYWSFGTMVFECIAGYRPFLHHL-Q ird5_Dmel TMVQSVVGTRHYYAPEVVEN--------GFYNSTVDLWSFGVIAYELVTGELPFIPHQ-T ik2_Dmel QPFASLYGTEEYLHPDLYERAVLRKSIQRSFTANVDLWSIGVTLYHVATGNLPFRPFG-G IKKe_Mmus EKFVSVYGTEEYLHPDMYERAVLRKPQQKAFGVTVDLWSIGVTLYHAATGSLPFIPFG-G IKKb_Mmus SLCTSFVGTLQYLAPELLEQ--------QKYTVTVDYWSFGTLAFECITGFRPFLPNW-Q IKKa_Mmus SLCTSFVGTLQYLAPELFEN--------KPYTATVDYWSFGTMVFECIAGYRPFLHHL-Q TBK1_Mmus EQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFE-G TBK1_Spur EAFKSLYGTEEYLHPDLYERAVLGKRNRTEFTAQTDLWSLGVTFFHTATGSLPFRA---- IKKe_Spur ENFTSLHGTEEYLHPKVFERAVLRKPAALPFDARIDLWSIGATLYHLATGQLP------- IKKa_Spur ------------------------------------------------------------ AqueK157_Aque SKAQSLVGTPQYVAPEIIDQ--------DSHGRPVDFWSFGVVAFELVTGIRPFLHKSRR AqueK158_Aque EHFTSLHGTEEYLYPAMYERALINYRSKEEFLDKVDLWSLGATFFHLATGRLPF------ TBK1_Hsap PRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILE IKKe_Hsap PRRNKEIMYRITTEKPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILE IKKb_Hsap PVQW---HSKV-RQKSEVDIVVS-EDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLM IKKa_Hsap PFTW---HEKI-KKKDPKCIFAC-EEMSGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLN ird5_Dmel LKNI---ILNL-IKKPAKCIAIT-EDPEDNTRFVN------------------------- ik2_Dmel -RKNRETMHQITTKKASGVISGTQLSENGPIEWSTTLPPHAHLSQGLKTLVTPLLAGLLE IKKe_Mmus PRRNKEIMYRITTEKPAGAISGTQKQENGPLEWSYSLPITCRLSMGLQNQLVPILANILE IKKb_Mmus PVQW---HSKV-RQKSEVDIVVS-EDLNGAVKFSSSLPFPNNLNSVLAERLEKWLQLMLM IKKa_Mmus PFTW---HEKI-KKKDPKCIFAC-EEMTGEVRFSSHLPQPNSLCSLIVEPMESWLQLMLN TBK1_Mmus PRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPLSCSLSQGLQALLTPVLANILE TBK1_Spur ------------------------------------------------------------ IKKe_Spur ------------------------------------------------------------ IKKa_Spur ------------------------------------------------------------ AqueK157_Aque PLEW---IGPT-RNKRDNCIYIT-F-NNGQLEYYDSIPSPHQLSSAFAGELTKWLQVVLH AqueK158_Aque ------------------------------------------------------------ TBK1_Hsap ADQEKCWGFDQFFAE----------------------TSD IKKe_Hsap VEQAKCWGFDQFFAETSDILQRVVVHVFSLSQAVLHHIYI IKKb_Hsap WHPR---------------------------------QRG IKKa_Hsap WDPQ---------------------------------QRG ird5_Dmel --------------------------------------QF ik2_Dmel ENREKTWSFDRFFHE----------------------VTL IKKe_Mmus VEEDKCWGFDQFFAETSDILQRTVIHVFSLPQAVLHHVYI IKKb_Mmus WHPR---------------------------------QRG IKKa_Mmus WDPQ---------------------------------QRG TBK1_Mmus ADQEKCWGFDQFFAE----------------------TSD TBK1_Spur ---------------------------------------H IKKe_Spur ---------------------------------------F IKKa_Spur ---------------------------------------K AqueK157_Aque QESE---------------------------------KRG AqueK158_Aque ----------------------------------------