CLUSTAL W (1.83) multiple sequence alignment IRE2_Hsap -------------FNP--KDVLGRGAGGTFVFRGQFEGR-AVAVKRLLRECFGLVRREVQ IRE1_Hsap -------------FCP--KDVLGHGAEGTIVYRGMFDNR-DVAVKRILPECFSFADREVQ ire-1_Dmel -------------FST--NEVLGKGCEGTFVFKGTFEER-FVAVKRLLPECFTFADREVA IRE2_Mmus -------------FNP--KDVLGRGAGGTFVFRGQFEGR-AVAVKRLLRECFGLVRREVQ IRE1_Mmus -------------FCP--KDVLGHGAEGTIVYKGMFDNR-DVAVKRILPECFSFADREVQ ire-1_Cele -------------YSP--SDILGTGCEGTVVYRGTFDGR-EVAVKRVVSEFVKFAHREAD IRE1_Scer -------------VVS--EKILGYGSSGTVVFQGSFQGR-PVAVKRMLIDFCDIALMEIK IreA_Ddis -------------IIT--NKILGTGSCGTIVYEGKMEGR-KVAVKRMLSQFVKFADREVS IrlA_Ddis ------------------NNIIGRGSNGTLVFRGIWNDRIPVAVKQMQKAFNPHISKEIE IrlB_Ddis -------------FNRNESNILGRGSNGTLVFKGLWSDKIPVAIKQMQKAFNPLINKEVE IrlB_C2d_Ddis -------------FNRNESNILGRGSNGTLVFKGLWSDKIPVAIKQMQKAFNPLINKEVE IrlC_Ddis -------------FNRKEENVLGRGSNGTLVFKGIWNNRIPVAIKQMQKMFNPLISKEIE IrlD_Ddis -------------FSRKDEFIIGRGSNGTLVFKGIWNDRIPVAIKQMHKAFNPLISKEIE IrlE_Ddis -------------KKE--SNILGRGSNGTLVFKGIWNNRIPVAIKQMQKMFNPLISKEIE IrlF_Ddis ---------------E--SNILGRGSNGTLVFKGIWSDKIPVAIKQMQKAFNPLINKEVE IrlF_C2d_Ddis ---------------E--SNILGRGSNGTLVFKGIWSDKIPVAIKQMQKAFNPLINKEVE 10577_Tthe ----------------------------------VNIGR-EIAVKQLLKDNKDLASKEIQ IRE1_Spur ------------------------------------------------------------ CC1G_06931_Ccin -------------VVS--DTILGFGSHGTVVFQGSLQGR-AVAVKRLLKDFVTLASREVS AqueK159_Aque ------------------------------------------------------------ AqueK160_Aque ------------------------------------------------------------ AqueK161_Aque -------------YDK--NSLLGKGASST-VYKGTFKRE-GVAVKRMKEE-LSD--DDKK AqueK162_Aque -------------YDK--KSLLGTGASST-VYKGTFKEE-DVAVKRMKEE-LSD--EYKE AqueK163_Aque -------------YDK--KSLLGKGASST-VHKGTFKEE-AVAVKRMKEE-LSD--EYKD AqueK164_Aque ------------------------------VYKGQFKGQ-DIAVKKVGKKDVIEDITEIK AqueK165_Aque -------------FDK--KLLLGKGASST-VHKGTFKEE-DVAVKRMKEE-LSD--EYKE AqueK166_Aque -------------VCE--DSLLGKGKSST-VRRGTYNGQ-EVAVKRLYEKTLSS--EDIN AqueK167_Aque -------------YDV--SIKLGQGASSI-VHKGTYEGQ-EVAVKKMKDK-LTD--DAKL AqueK168_Aque GGGAIEATDGERGSNR--SSIALSDSTQSIYRNGSFDSR-PVAVKRVIQNYFDLADREVA AqueK169_Aque -------------YFR--NEKLGDGASGTTVYKGQFSGK-DVAVKVGKKTAIRD--LEKK IRE-2_Smoe --------------------VIGYGSHGTRILEGKLDQR-QVAVKSILSGFYHKASKEIA IRE-1_Smoe --------------------VIGYGSHGTRILEGKLDQR-QVAVKSILSGFYHKASKEIA IRE2_Hsap LLQE--SDRHPNVLRYFCTERG--PQFHYIALELCRASLQEYVENPDLD----------- IRE1_Hsap LLRE--SDEHPNVIRYFCTEKD--RQFQYIAIELCAATLQEYVEQKDFA----------- ire-1_Dmel LLRE--SDAHENVVRYFCTEQD--RQFRYIAVELCAATLQDYTEGDRSL----------- IRE2_Mmus LLQE--SDRHPNVLRYFCTEHG--PQFHYIALELCQASLQEYVESPDLD----------- IRE1_Mmus LLRE--SDEHPNVIRYFCTEKD--RQFQYIAIELCAATLQEYVEQKDFA----------- ire-1_Cele LLRE--SDTHPHVIRYFCMESD--SQFRYLALELCIASLNDYVEQKEVQ----------- IRE1_Scer LLTE--SDDHPNVIRYYCSETT--DRFLYIALELCNLNLQDLVESKNVS----------- IreA_Ddis ILIH--SDEHTNVVRYYAKEED--DEFIYLAISFCQKSLDMYVQQTLSLQISPTDSPSIQ IrlA_Ddis VLIRLTSNNCSNMIRYIDQEED--QLFVYLGLTLCEESLQDLMESKRYK----------- IrlB_Ddis ALISLTSKNCSNMIRYIDKEED--KLHVYLGLTLCDGSLQNLVESGKLN----------- IrlB_C2d_Ddis ALISLTSKNCSNMIRYIDKEED--KLHVYLGLTLCDGSLQNLVESGKLN----------- IrlC_Ddis VLITLTNKNCYNIVRYIDQEED--ESCVYLGLTLCDGSLQNLVEKGDNNL---------- IrlD_Ddis VLITLTNKNCNNIVRYIDQEED--DMFVYLGLTLCNGSLQNLVEKDLEINLIST------ IrlE_Ddis ILIGLTNK-NLNLVGYIDQEED--ENCVYLGLTLCDGSLQSLYDQSKLN----------- IrlF_Ddis ALITLTNKNCSNMIRYIDKEED--KHFVYLGLTLCDVSLQYLVENGKLN----------- IrlF_C2d_Ddis ALITLTNKNCSNMIRYIDKEED--KHFVYLGLTLCDVSLQYLVENGKLN----------- 10577_Tthe MLIK---LQHKNIIKYYYFEET--KDHILLGLEKCVGSISDLIDYANRK----------- IRE1_Spur ------------------------------------------------------------ CC1G_06931_Ccin ILQE--SDDHPNVIRYYYQEAH--ANFLYIALELCPASLADIIETPDRE----------- AqueK159_Aque ------------------------------------------------------------ AqueK160_Aque -------------------------EYYYLAFQLCLTSLENFIKNEEKR----------- AqueK161_Aque FLLS---IKHDNIVLVHCIY----------------------FKKLKKV----------- AqueK162_Aque LLLN---IKHENIVLVLCIY----------------------FKEFKEV----------- AqueK163_Aque LLKN---IKHENIVLVLCIY----------------------FKEFEKV----------- AqueK164_Aque LLMK---CRNQNIVEYYHFESD--IEYHYLAFQLCLTSLEKFIIDKKQR----------- AqueK165_Aque LLLN---IKHKNIVLVLCIESY--QGLDHIVLELCLASFHQYFKEFEKV----------- AqueK166_Aque LLLT---IQHENIVKILAIEDG--LENQYIVLELCLASLDLFCVNYKKV----------- AqueK167_Aque LLLD---IKHENIVQLLNIETDEHNEHDYIILELCLASLSKYFKHYETV----------- AqueK168_Aque LLRE--SDQHPNVIRYFCMEED--PTFRYLALELCSATLHEYVEGQKMS----------- AqueK169_Aque ILER---CRHENIVEYYHFDSD--IEYNYLAFQLCDISLENFIENEDKR----------- IRE-2_Smoe ALIEL--DTHPNVVRYYSMEQD--NDFVYIALERCSFNLETFILVHAAGA---------- IRE-1_Smoe ALIEL--DTHPNVVRYYSMEQD--NDFVYIALERCSFNLETFIVVHAAGA---------- IRE2_Hsap ----------------------RG------------------------------------ IRE1_Hsap ----------------------HL------------------------------------ ire-1_Dmel ----------------------EL------------------------------------ IRE2_Mmus ----------------------RW------------------------------------ IRE1_Mmus ----------------------HL------------------------------------ ire-1_Cele ----------------------QN------------------------------------ IRE1_Scer ----------------------DENLK-------------L------------------- IreA_Ddis SSNNNGNGNNGN-----NNNNNQ-II---------------------------------- IrlA_Ddis ----------------------EFIEK-------------TTTT-NITTTFNNNIIDEN- IrlB_Ddis ----------------------DFVIS-------------S------------------- IrlB_C2d_Ddis ----------------------DFVIS-------------S------------------- IrlC_Ddis -------------------TLTQFLGY-------------DINS-------------SS- IrlD_Ddis -S-NN--EN-NN-----NNKLKNFIG---------------------------------- IrlE_Ddis ----------------------EFINQ-------------NNNQ-N-----------NN- IrlF_Ddis ----------------------EFINS-------------S------------------- IrlF_C2d_Ddis ----------------------EFINS-------------S------------------- 10577_Tthe ----------------------NKKKSEQDLKALYNIKTDF------------------- IRE1_Spur ------------------------------------------------------------ CC1G_06931_Ccin ----------------------AF-RD-------------I------------------- AqueK159_Aque ------------------------------------------------------------ AqueK160_Aque ----------------------EAILR--------------------------------- AqueK161_Aque ----------------------MDKFD--------------------------------- AqueK162_Aque ----------------------MNKFN--------------------------------- AqueK163_Aque ----------------------TNKFD--------------------------------- AqueK164_Aque ----------------------EVILQ--------------------------------- AqueK165_Aque ----------------------MNKFN--------------------------------- AqueK166_Aque ----------------------ANRFS--------------------------------- AqueK167_Aque ----------------------SSQFV--------------------------------- AqueK168_Aque ----------------------EF------------------------------------ AqueK169_Aque ----------------------KDLIR--------------------------------- IRE-2_Smoe -------DNRTEVNEFEEKELQEILQQ-------------KLTLWD-----------RSC IRE-1_Smoe -------DNRTEVNEFEEKELQEILQQ-------------KLTLWD-----------RSC IRE2_Hsap --GLEPEVVLQQLMSGLAHLHS-LHIVHRDLKPGNILITGPDSQ---------------- IRE1_Hsap --GLEPITLLQQTTSGLAHLHS-LNIVHRDLKPHNILISMPNAH---------------- ire-1_Dmel QNHIDVWQVLSQAASGLSHLHS-LDIVHRDIKPQNVLISLPDAK---------------- IRE2_Mmus --GLEPTTVLQQMMSGLAHLHS-LHIVHRDLKPANILMAGPDSQ---------------- IRE1_Mmus --GLEPITLLHQTTSGLAHLHS-LNIVHRDLKPHNILLSMPNAH---------------- ire-1_Cele -VTIALRDIMKQATDGLAHLHA-SKIVHRDMKPQNVLITMASQR---------------- IRE1_Scer QKEYNPISLLRQIASGVAHLHS-LKIIHRDLKPQNILVSTSSRFTAD------------- IreA_Ddis -IDNKTKQMILELFKGLEHLHS-LNIVHRDIKPHNVLIDP-------------------- IrlA_Ddis LYEQRILSLFKDVINGINFLHC-QDIVHNDLNPRNILVHK-------------------- IrlB_Ddis --NKSIIELAKDILFGIQFLHS-HDIVHNDLNPRNILTLIGKTSNN-------------- IrlB_C2d_Ddis --NKSIIELAKDILFGIQFLHS-HDIVHNDLNPRNILTLIGKTSNN-------------- IrlC_Ddis KNNSRLLELIKDIVYGIQFLHQ-QGIVHNDLNPRNILIKD-------------------- IrlD_Ddis -SELRLLELIKDIVYGIQFLHQ-QGIVHNDLNPRNILIKD-------------------- IrlE_Ddis NNNNRVLDLIIGMINGVIFLHD-QNIVHNDLNPRNILVKD-------------------- IrlF_Ddis --GKSLNELAKDIINGVQFLHS-HDIVHNDLNPRNILTLSTNKNNNNNNKSNNKIKSNNN IrlF_C2d_Ddis --GKSLNELAKDIINGVQFLHS-HDIVHNDLNPRNILTLSTNKNNNNNNKSNNKIKSNNN 10577_Tthe FIKSTMKNTFKDCLEGLSYLHS-QGVIHRDIKPENILIHYNK------------------ IRE1_Spur --------------------------VHRDIKPHNVLISQPNQH---------------- CC1G_06931_Ccin AISFDPKRALKQITSGLKHLHA-LKLVHRDIKPQNILITTNKSTG--------------- AqueK159_Aque --------------------------IHRDIKPGNILLVQKSS----------------- AqueK160_Aque DFVVSKKEILHGAIRGLNHLHNEHNIVHRDVKPSNILIVQRNSG---------------- AqueK161_Aque GLTVVKKNVNQDAVKGLEYLHE-QNIVHRDIKPGNILLVQKSS----------------- AqueK162_Aque GLTVVKKDVNQDAVRGLEYLHE-QNIVHRDIKPGNILLVQKSP----------------- AqueK163_Aque GLTVVKKDVNQDAVRGLEYLHE-QSIVHRDIKPGNILLVQKSS----------------- AqueK164_Aque GFIVNKRDIISDAIRGLNHLHE-KHIVHRDIKPSNILLVQRHSF---------------- AqueK165_Aque GLTVVKKDVNQDAVRGLEYLHE-QNIVHRDIKPGNILLVQKSS----------------- AqueK166_Aque GFIVVKENIIRDAVKGLEYLHK-RWIVHRDIKPGNILLLQKGS----------------- AqueK167_Aque GLNVVIREILQDAVKGMEYLHK-RNVVHRDLKPGNILLVQKSSS---------------- AqueK168_Aque --SIDEKHIIAESMSGINHLHS-LGIVHRDLKPQNVLLRTS-SS---------------- AqueK169_Aque DFYVNKKEILFDSIKGLSYLHK-ENIVHRDVKPSNILLVRRNSS---------------- IRE-2_Smoe LPSPLLMRLMRDVLEGLVHLHK-LGYVHRDLKPQNVLILRSG------------------ IRE-1_Smoe LPSPLLMRLMRDVLEGLVHLHK-LGYVHRDLKPQNVLILRSG------------------ :*.*::* *:* IRE2_Hsap --------GLGRVVLSDFGLCKKLPAGRCSFSL--HSG-IPGTEGWMAPELLQLL----- IRE1_Hsap --------GKIKAMISDFGLCKKLAVGRHSFSR--RSG-VPGTEGWIAPEMLSED----- ire-1_Dmel --------GKVRVMISDFGLCKKLNFGKTSFSR--RSG-VTGTDGWIAPEMMRS------ IRE2_Mmus --------GQGRVVISDFGLCKKLPVGRCSFSL--HSG-IPGTEGWMAPELLQL------ IRE1_Mmus --------GRIKAMISDFGLCKKLAVGRHSFSR--RSG-VPGTEGWIAPEMLSED----- ire-1_Cele --------GEMRAVISDFGLCKRVQPGKNSISRGIASG-LAGTDGWIAPEVLIS------ IRE1_Scer ---QQTGAENLRILISDFGLCKKLDSGQSSFRTNLNN--PSGTSGWRAPELLEESNNLQC IreA_Ddis ---------NNRVKISDMGLGKLLDNDDQSLTF--TS----DSHGWQPAEYLNGT----- IrlA_Ddis ----------GNFVISDLGLSKMQVETSYSFTN--N-A-PTGQEGYHPIEVLQE------ IrlB_Ddis -----NNSSNNSFIISDLGLSKMEVESSYSFTS--N-I-PTGQGGYHPFEVLQS------ IrlB_C2d_Ddis -----NNSSNNSFIISDLGLSKMEVESSYSFTS--N-I-PTGQGGYHPFEVLQS------ IrlC_Ddis ----------DRFIISDLGLSKMEVTSSYSFTM--H-A-PTGQEGFHPAEVLLE------ IrlD_Ddis ----------DRFIISDLGLSKMEVTSSYSFTM--H-A-PTGQEGFHPAEVLLE------ IrlE_Ddis ----------NRLIISDLGLSKMNVSSTYNFST--NAI-PTGQDGYHPVEVLLE------ IrlF_Ddis SNNNSNNNSNNSFIISDLGLSKMEVESSYSFTT--N-V-PTGQGGYHPVEVLQS------ IrlF_C2d_Ddis SNNNSNNNSNNSFIISDLGLSKMEVESSYSFTT--N-V-PTGQGGYHPVEVLQS------ 10577_Tthe -----------EIKLADFGLSKNISKTNVIFT--N----DIGTWGWRPLEQIDN------ IRE1_Spur --------GKVKAMISDFGLCKKLSAGRMSFSR--RSG-VAGTDGWIAPEMLTGQ----- CC1G_06931_Ccin -----RGRPTYRMLISDFGLCKKLDVDQTSFLPTMNGGMGAGTVGWRAPEILRGEVKLDD AqueK159_Aque -------SSEVKAVLADFGISTELNE-REAVTR--Q-R-GRRTDTWMAPELLLDDL---- AqueK160_Aque -------SMQIKAVISDFGIATELEPDRYSQTT--I-G-LKGTLMWLAPELVNKTV---- AqueK161_Aque -------SSEVKAVLADFGISTKLNN-RDAVTT--Q-R-RRGTDTWMGPELLLDDI---- AqueK162_Aque -------LSEVKAVLADFDLSAKLDDDRSSKTT--L-N-KRGTLSWMAPELLVEDG---- AqueK163_Aque -------SSEVKAVLADFGLSTKLDDDQFSKTT--V-D-GRGTKAYIPPELLVEDG---- AqueK164_Aque -------TKEIKAVIADFGTATEIDFDEYLKTI--S-R-VRGTLVWLAPELLGDKK---- AqueK165_Aque -------SSEVKAVLADFDLSTKLDDDRSLKTT--L-N-KRGTLSWMAPELLVKDG---- AqueK166_Aque -------SSEVKAVLADFGISTKLTS-RDSKTT--H-R-GRVTDTWMAPELLLDDP---- AqueK167_Aque -------SADVKAVLADFGISVTLIDDLNSLTT--R-T-ARGTDTWKAPELLLDNR---- AqueK168_Aque --------LKVRALISDFGLCRKLPDGRGSFTA--QSG-ILGTEGWIAPEMFQDR----- AqueK169_Aque -------SMKIKAVISDFGIAAELDPGRISKTT--T-G-LKGTLLWVAPELLNKRR---- IRE-2_Smoe --------TFLSAKISDMGISKRLNDGASGIDK--LTT-GMGSSGWQAPEQIQG------ IRE-1_Smoe --------TFLSAKISDMGISKRLNDGASGIDK--LTT-GMGSSGWQAPEQIQG------ ::*:. : * . IRE2_Hsap ------------------------------------------------P-PDSPTSAVDI IRE1_Hsap ------------------------------------------------C-KENPTYTVDI ire-1_Dmel ---------------------------------------------------QRTTTAVDI IRE2_Mmus ------------------------------------------------P-PDSPTSAVDI IRE1_Mmus ------------------------------------------------C-KDNPTYTVDI ire-1_Cele ---------------------------------------------------ASTSYPVDI IRE1_Scer QVETEHSSSRHTVVSSDSFY-------------------------DPFT-KRRLTRSIDI IreA_Ddis ---------------------------------------------------NRNTKKVDI IrlA_Ddis ---------------------------------------------------KRKTKSVDI IrlB_Ddis ---------------------------------------------------KRMTKSVDI IrlB_C2d_Ddis ---------------------------------------------------KRMTKSVDI IrlC_Ddis ---------------------------------------------------KRKTKSVDI IrlD_Ddis ---------------------------------------------------KRKTKSVDI IrlE_Ddis ---------------------------------------------------KRKTKSVDV IrlF_Ddis ---------------------------------------------------KRMTKSVDI IrlF_C2d_Ddis ---------------------------------------------------KRMTKSVDI 10577_Tthe ---------------------------------------------------QPLTYNTDV IRE1_Spur ---------------------------------------------------DRTTTAIDI CC1G_06931_Ccin -LS----------------DDHSMSSRGSVSTINGSSSSSSTSGLSTAK-PTRLTKSVDI AqueK159_Aque ------------------------------------------------T-DCKFSRESDI AqueK160_Aque ---------------------------------------------------KKFSKAVDI AqueK161_Aque ------------------------------------------------K-ACKFSRESDI AqueK162_Aque ------------------------------------------------L-ELQFSLQSDI AqueK163_Aque ------------------------------------------------S-KLKFSPQSDI AqueK164_Aque ---------------------------------------------------PKFSKAIDI AqueK165_Aque ------------------------------------------------L-ELQFSLQSDI AqueK166_Aque ------------------------------------------------S-GCKFSRQSDI AqueK167_Aque ------------------------------------------------K-QRKCGRESDI AqueK168_Aque ---------------------------------------------------TRVTCAVDI AqueK169_Aque ------------------------------------------------DPRLKYSKAVDV IRE-2_Smoe ---------------------------------------------------ERQTRAVDM IRE-1_Smoe ---------------------------------------------------ERQTRAVDM *: IRE2_Hsap FSAGCVFYYVLSGGSHPFGD-SLYRQA----NIL---TGAPCLAHLEEEV----HDKVVA IRE1_Hsap FSAGCVFYYVISEGSHPFGK-SLQRQA----NIL---LGACSLDCLHPEK----HEDVIA ire-1_Dmel FSLGCVYYYVLSGGHHAFGD-NLKRQA----NIL---SHEYNLAKLRPEDDSEDSRIILA IRE2_Mmus FSAGCVFYYVLSGGSHPFGE-SLYRQA----NIL---SGDPCLAQLQEET----HDKVVA IRE1_Mmus FSAGCVFYYVISEGNHPFGK-SLQRQA----NIL---LGACNLDCFHSDK----HEDVIA ire-1_Cele FSLGCIFYYVLTSGTHPFGK-SLHRQA----NIV---NGEYTLNKLAD-L----DDWSLA IRE1_Scer FSMGCVFYYILSKGKHPFGD-KYSRES----NII---RGIFSLDEMKCLHD--RSLIAEA IreA_Ddis FSLGCVVYYLLT-GAHPFGH-RYNREK----NVL---KGKFDIDQIK--------HLPDI IrlA_Ddis FSLGCILFYLLTNGQHPFGNNKLLRVA----NIV---YDKPDLEPLK--------FNAPA IrlB_Ddis FSLGCILFYLLTNGQHPFGNDKLFRIV----NII---SNKMNLTPLN--------SNQLA IrlB_C2d_Ddis FSLGCILFYLLTNGQHPFGNDKLFRIV----NII---SNKMNLTPLN--------SNQLA IrlC_Ddis FSMGCILFYLMTGGQHPFGD-KFYRIV----NIL---TDKPILEPLK--------HNLVA IrlD_Ddis FSMGCILFYLMTGGQHPFGD-KFFRMA----NIL---TDKPILEPLK--------HNLVA IrlE_Ddis FSLGCLIYFIMTNGAHPFGD-KFSRLR----YIT---KSKYNLSQLS-------NLNLVA IrlF_Ddis FSLGCILFYLFTNGQHPFGNDKLFRIY----NIM---LNKVNLELLG--------HNLLA IrlF_C2d_Ddis FSLGCILFYLFTNGQHPFGNDKLFRIY----NIM---LNKVNLELLG--------HNLLA 10577_Tthe FSLGCVFYYIYTQGGHPFGE-YLRM-------------------------E-----DETL IRE1_Spur FSLGCVFYYVLSNGKHPFGD-SLHRQA----NII---SGEYSLDLLP-------PDDEIA CC1G_06931_Ccin FALGCLYYYTLTNGSHPYGD-RFEREV----NIL---KDAKSLDLLERFGE--E--GTEA AqueK159_Aque FSMGCIIYYVLTKGRHPFNK-GHDNDYTVHQNIKNYM--ICDFQ----LL----NDKPVA AqueK160_Aque FSMGCVMYYVLSDGHHPFGN-DIV---AIIQNFG---THSYTLDDISDEV----KDRETA AqueK161_Aque FSMGCVIYFVETGGSHPFDK-GHDDDYTIHQNVKNYD--RCDFR----LL----HGKPKA AqueK162_Aque FSMGCVIYFAETDGNHPFDT-GDSRGAAIHLNVKNYN--PCDFH----LL----NGKPKA AqueK163_Aque FSMGCVIYFAETDGHHPFDT-GDSRGAAIHQNVKDYN--PCDFR----LL----DGKPIA AqueK164_Aque FSMGCVIYYVLSDGHHPLGD-ESL---DIGIALKSYSTHSFTLDGISDEV----EDKEPA AqueK165_Aque FSMGCVIYFAETDGNHPFDT-GDSRGAAIHQNVKNYN--PCDFH----PL----NGKPKA AqueK166_Aque FSMGCVTYYLITKGHHPFNR-GHDNVFRIHQNVKNYV--TCDFQ----LL----NDKPLA AqueK167_Aque FAMGCVIYFAETGGNHPFDT-GDN--ADIDQNVKMYK--KCDFS----LL----DDKPKA AqueK168_Aque FAMGCVIYYVLSCGGHPFGP-PLKRQA----NIE---AGDFSLKALIG------EDRYTA AqueK169_Aque FSMGCVMYYVLSDGRHPFGE-DII---TIVQNFG---THSYRLDGISGKV----EDREPA IRE-2_Smoe FSVGCLLYFCITGGQHPFGG-RLERDM----NIV---SGKMDLFAVD--------HYPEA IRE-1_Smoe FSVGCLLYFCVTGGQHPFGG-RLERDM----NIV---SGKMDLFAVD--------HYPEA *: **: :: : * *. . IRE2_Hsap RDLVGAMLSPLPQP----------------------RPSAPQVLAHPFF IRE1_Hsap RELIEKMIAMDPQK----------------------RPSAKHVLKHPFF ire-1_Dmel EQLISDMIHKDPQS----------------------RPPARCIGNHPLF IRE2_Mmus LDLVRAMLSLLPQD----------------------RPSAGWVLAHPLF IRE1_Mmus RELIEKMIAMDPQQ----------------------RPSAKHVLKHPFF ire-1_Cele DDLISSMLNVEPLH----------------------RLTADAVLNHPFF IRE1_Scer TDLISQMIDHDPLK----------------------RPTAMKVLRHPLF IreA_Ddis HQLVHSMIQFEPEK----------------------RPDIGECINHPFF IrlA_Ddis LDLVRLMISQDEKK----------------------RPTIDTILNHPLF IrlB_Ddis CTLIKSMISKDESI----------------------RPTIQNVLNHPLF IrlB_C2d_Ddis CTLIKSMISKDESI----------------------RPTIQNVLNHPLF IrlC_Ddis CDLISQMISKNESD----------------------RPTIEKILLHPFF IrlD_Ddis CDLISQMISKNESD----------------------RPTTENILLHPFF IrlE_Ddis THLIELMISYDESK----------------------RPTLSSVLKHPLF IrlF_Ddis CDLIKSMISNDESK----------------------RPTIENVLNHPLF IrlF_C2d_Ddis CDLIKSMISNDESK----------------------RPTIENVLNHPLF 10577_Tthe KDLIQKMIHNDQSK----------------------RLTVKECLKHPYF IRE1_Spur HQLITQMVDPYFDT----------------------RPEANAILRHPFF CC1G_06931_Ccin CDLIEKMLDPEASE----------------------RPDTTACLLHPFF AqueK159_Aque RALIKNMMKHNKDS----------------------RPSASEVLDDPYF AqueK160_Aque KHLIKQMIHKDKDL----------------------RISVEEVLNHCYF AqueK161_Aque TALIKKTIQLDRAS----------------------RPSASEVLDDPYF AqueK162_Aque TALILKMIKRDRAS----------------------RPSASEVLDDPYF AqueK163_Aque SALINKMIQHNRAS----------------------RPSASEVLQDPYF AqueK164_Aque KDLIMQMMHENKDL----------------------RIPIGKVLDHCYF AqueK165_Aque TALIFKMITRDRAS----------------------RPSASEVLDDRYF AqueK166_Aque RALIKNMIKYNKDS----------------------RPCASEVLGDPYF AqueK167_Aque KDLIEKMIQLDKYS----------------------RPTASVVLQDPYF AqueK168_Aque EHLVNNMISFNSKL----------------------RPTADEVLHHCLF AqueK169_Aque KDLIVQMIHENKDLSVVSDIYKTQTGTKFILNTDHKAGDQQETLQHIYT IRE-2_Smoe IDIISSLLAMDPKD----------------------RPTSMQVKLHPFF IRE-1_Smoe IDIISSLLAMDPKD----------------------RPTAMQVKLHPFF :: : .