CLUSTAL W (1.83) multiple sequence alignment IRR_Hsap ISIIRELGQGSFGMVYEGLARGLEA--GEE-STPVALKTVNELASPRECIEFLKEASVMK INSR_Hsap ITLLRELGQGSFGMVYEGNARDIIK--GEA-ETRVAVKTVNESASLRERIEFLNEASVMK IGF1R_Hsap ITMSRELGQGSFGMVYEGVAKGVVK--DEP-ETRVAIKTVNEAASMRERIEFLNEASVMK InR_Dmel IIQLAPLGQGSFGMVYEGILKSFPP--NGV-DRECAIKTVNENATDRERTNFLSEASVMK IRR_Mmus IAIIRELGQGSFGMVYEGLARGLEA--GEE-STPVALKTVNELASARERVEFLKEASVMK INSR_Mmus ITLLRELGQGSFGMVYEGNAKDIIK--GEA-ETRVAVKTVNESASLRERIEFLNEASVMK IGF1R_Mmus ITMNRELGQGSFGMVYEGVAKGVVK--DEP-ETRVAIKTVNEAASMRERIEFLNEASVMK daf-2_Cele VVLGQQCGEGSFGKVYLGTGNNVVSLMGDR-FGPCAIKINVDDPASTENLNYLMEANIMK ILGFR_Spur VVLNRKLGEGAFGTVYGGEA--LLD--DNK-WAAVAVKTLKLGASVEEKLDFLSEAEVMK InsRL_Spur LEIIRELGKGSFGMVYEGLAKGILP--EEEEISRVAIKSVQANASMRDRIEFLNEASVMK : *:*:** ** * . *:* .: : ::* **.:** IRR_Hsap AFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAE-NNPG----------- INSR_Hsap GFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAE-NNPG----------- IGF1R_Hsap EFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEME-NNPV----------- InR_Dmel EFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEER-DEAMMTYLNRIGVTG IRR_Mmus AFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAE-NNPG----------- INSR_Mmus GFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDAE-NNPG----------- IGF1R_Mmus EFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEVEQNNLV----------- daf-2_Cele NFKTNFIVKLYGVISTVQPAMVVMEMMDLGNLRDYLRSKREDEVF-NETDC--------N ILGFR_Spur RFNHKNIVNLLGVCTRGEPMYAVMEFMLYGDLKTFLLGRRHLVGE-GVYER--------N InsRL_Spur LIDAHNVVRLLGVVSKGQPTYVIMEFMAQGDLKNWLRARRPENQ-QDLPLI--------D : :*.* ** : :* .:**:* *:*: * . * IRR_Hsap -LPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYE INSR_Hsap -RPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYE IGF1R_Hsap -LAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYE InR_Dmel NVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYE IRR_Mmus -LPQPALSDMIQMAGEIADGMAYLAAKKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYE INSR_Mmus -RPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYE IGF1R_Mmus -LIPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYE daf-2_Cele FFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLFY ILGFR_Spur Q-HVMCPDQLTSMVSDIASGLSYLASINYVHRDLACRNCLVDASYTVKIGDFGMTRALYD InsRL_Spur RKSVPTLEQLLNMAAEIADGMSFLAARKYVHRDLSARNCLVSGEGTCKVADFGLARDIYQ : . . :*..*:::* : :: ****:.***:: . * *:.***::* :: IRR_Hsap TDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVL INSR_Hsap TDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVL IGF1R_Hsap TDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVL InR_Dmel TDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVL IRR_Mmus TDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVL INSR_Mmus TDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVL IGF1R_Mmus TDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVL daf-2_Cele HDYYKPSGKRMMPVRWMSPESLKDGKFDSKSDVWSFGVVLYEMVTLGAQPYIGLSNDEVL ILGFR_Spur SDYYRLGKRSKLPVRWMAPESLTEGIFTTMSDVWSLGVVIYEVVTFGSFPYQELSNAEVL InsRL_Spur SDYYRKERGGMLPIRWMAPESVKDGVFQASSDVWSFGILLWEMATLGELPYQGLSNEEAG ***: :*:***.***: :* : : **::*:*::::*:.::. ** *** :. IRR_Hsap KFV-MDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQ---------E INSR_Hsap KFV-MDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNL-----------L IGF1R_Hsap RFV-MEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIK---------E InR_Dmel RYV-IDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAY-----------L IRR_Mmus KFV-MDGGVLEELENCPIQLQELMRLCWQHSPRLRPTFVHILDRIQ---------D INSR_Mmus KFV-MDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNL-----------L IGF1R_Mmus RFV-MEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIGSIK---------D daf-2_Cele NYIGMARKVIKKPECCENYWYKVMKMCWRYSPRDRPTFLQLVHL-----------L ILGFR_Spur DYI-RNRNSLRPPEGCSPALGALMMQCWAIQPQHRPTAKDVNDILCQRPHLITPCL InsRL_Spur EYI-KGGNVLRPPENCPEKMQEIMMACWQYQEKLRPLFGEIILNLQDYGLLRDSFA :: : : * :* ** ** .: