CLUSTAL W (1.83) multiple sequence alignment TYK2_Hsap LKKIRDLGEGHFGKVSLYCYDPT------------------NDG--TGEMVAVKALKADC TYK2~b_Hsap ITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPS- JAK3_Hsap LKYISQLGKGNFGSVELCRYDPL------------------GDN--TGALVAVKQLQHS- JAK3~b_Hsap LEWHENLGHGSFTKIYRGCRHEVVD------------------GEARKTEVLLKVMDAK- JAK2_Hsap LKFLQQLGKGNFGSVEMCRYDPL------------------QDN--TGEVVAVKKLQHS- JAK2~b_Hsap LIFNESLGQGTFTKIFKGVRREVGDY-----------------GQLHETEVLLKVLDKA- JAK1_Hsap LKRIRDLGEGHFGKVELCRYDPE------------------GDN--TGEQVAVKSLKPES JAK1~b_Hsap LVQGEHLGRGTRTHIYSGTLMDYKDDE--------------GTSEEKKIKVILKVLDPS- hop_Dmel YPDSI--SLSDDGMMFTMRGDWIQQS------------------PVKDVSVTMKMLKS-- hop~b_Dmel YNMENMIGRGHYGTVYKGHLEFN-D----------------KDQ--PREQVAIKMLNTM- JAK3_Mmus LKYISLLGKGNFGSVELCRYDPL------------------GDN--TGPLVAVKQLQHS- JAK3~b_Mmus LEWHENLGHGSFTKIFRGRRREVVD------------------GETHDSEVLLKVMDSR- JAK2_Mmus LKFLQQLGKGNFGSVEMCRYDPL------------------QDN--TGEVVAVKKLQHS- JAK2~b_Mmus LIFNESLGQGTFTKIFKGVRREVGDY-----------------GQLHKTEVLLKVLDKA- JAK1_Mmus LKRIRDLGEGHFGKVELCRYDPE------------------GDN--TGEQVAVKSLKPES JAK1~b_Mmus IIQGEHLGRGTRTHIYSGTLLDYKDEE--------------GIAEEKKIKVILKVLDPS- TYK2_Mmus LKKIRDLGEGHFGKVSLYCYDPT------------------NDG--TGEMVAVKALKEGC TYK2~b_Mmus ITQLSHLGQGTRTNVYEGLLRVGGPDE---GKVDNGCPPEPGGTSGQQLRVVLKVLDPS- JAK1_Spur LKKEERLGSGHFGMVFRGVLMPR------------------QGI--PAE-IVAKVIKNDS JAK1~b_Spur -------GEGAFATIYLVACLDALDMT---------------DLDCDFRRVALKIQHPPC JAK2_Spur RTNWRHLDDGDFTEVWAADLRKKVG------------------NRPRKMRVAIKCPKMDA JAK2~b_Spur ------------------------------------------------------------ TYK2_Hsap GPQHRSGW-KQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPR--- TYK2~b_Hsap HHDIALAF-YETASLMSQVSHTHLAFVHGVCVR-GPE-NIMVTEYVEHGPLDVWLRR--- JAK3_Hsap GPDQQRDF-QREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQR--- JAK3~b_Hsap HKNCMESF-LEAASLMSQVSYRHLVLLHGVCMA-G-D-STMVQEFVHLGAIDMYLRK--- JAK2_Hsap TEEHLRDF-EREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQK--- JAK2~b_Hsap HRNYSESF-FEAASMMSKLSHKHLVLNYGVCVC-GDE-NILVQEFVKFGSLDTYLKK--- JAK1_Hsap GGNHIADL-KKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPK--- JAK1~b_Hsap HRDISLAF-FEAASMMRQVSHKHIVYLYGVCVR-DVE-NIMVEEFVEGGPLDLFMHR--- hop_Dmel DGN-FMEF-FRLAQTWSLIQSPQFLKLYGLT---LADPYTMVMEYSRYGPLNKFLHS--- hop~b_Dmel --QVSTDF-HREIGIMRTLSHPNIVKFKYWA----EKSHCIIMEYLQSGSFDIYLRF--- JAK3_Mmus GPDQQRDF-QREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQR--- JAK3~b_Mmus HRNCMESF-LEAASLMSQVSYPHLVLLHGVCMA-G-D-SIMVQEFVYLGAIDMYLRK--- JAK2_Mmus TEEHLRDF-EREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQK--- JAK2~b_Mmus HRNYSESF-FEAASMMSQLSHKHLVLNYGVCVC-GEE-NILVQEFVKFGSLDTYLKK--- JAK1_Mmus GGNHIADL-KKEIEILRNLYHENIVKYKGICMEDGGNGIKLIMEFLPSGSLKEYLPK--- JAK1~b_Mmus HRDISLAF-FEAASMMRQVSHKHIVYLYGVCVR-DVE-NIMVEEFVEGGPLDLFMHR--- TYK2_Mmus GPQLRSGW-QREIEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPR--- TYK2~b_Mmus HHDIALAF-YETASLMSQVSHMHLAFLHGVCVR-GSE-NIIVTEFVEHGPLDVWLRR--- JAK1_Spur ---RSDQF-QQEIRAMSYCDHKNIVKVLGYCED-NSNRLSLVMEYFPLGSLEKYLRE--- JAK1~b_Spur PRE-IKELHARLSRLPSQIDVRQSIMT-AECAHIYQDKSCMVTEYKSKGILLNLFNK--- JAK2_Spur PQSVQQKF-SQSVDLMSSWVHKHIIRFEGI----GAG-YMLVMEYASEGPLDHYLRSLLE JAK2~b_Spur ----QQKF-SQSVDLMSSWVHKHIIRFEGI----GAG-YMLVMEYASEGPLDHYLRSLLE . :: *: * : : TYK2_Hsap -H------SI--GLAQLLLFAQQICEGMAYLHA-QHYIHRDLAARNVLLDNDR------- TYK2~b_Hsap -ERG----HV--PMAWKMVVAQQLASALSYLEN-KNLVHGNVCGRNILLARLGLA-EGTS JAK3_Hsap -HRA----RL--DASRLLLYSSQICKGMEYLGS-RRCVHRDLAARNILVESEA------- JAK3~b_Hsap -RGH----LV--PASWKLQVVKQLAYALNYLED-KGLPHGNVSARKVLLAREGAD--GSP JAK2_Hsap -HKE----RI--DHIKLLQYTSQICKGMEYLGT-KRYIHRDLATRNILVENEN------- JAK2~b_Hsap -NKN----CI--NILWKLEVAKQLAWAMHFLEE-NTLIHGNVCAKNILLIREEDRKTGNP JAK1_Hsap -NKN----KI--NLKQQLKYAVQICKGMDYLGS-RQYVHRDLAARNVLVESEH------- JAK1~b_Hsap -KSD----VL--TTPWKFKVAKQLASALSYLED-KDLVHGNVCTKNLLLAREGID-SECG hop_Dmel -MPN-----V--TLHCLLDLMHGLVRGMHYLED-NKIIHNYIRCSNLYVTKYDPN--SYV hop~b_Dmel -TAP----NL--NNPRLVSFALDIANGMKYLSD-MGLIHRDLAARNILVDHNGD-----G JAK3_Mmus -HRA----RL--HTDRLLLFAWQICKGMEYLGA-RRCVHRDLAARNILVESEA------- JAK3~b_Mmus -RGH----LV--SASWKLQVTKQLAYALNYLED-KGLPHGNVSARKVLLAREGGD--GNP JAK2_Mmus -HKE----RI--DHKKLLQYTSQICKGMEYLGT-KRYIHRDLATRNILVENEN------- JAK2~b_Mmus -NKN----SI--NILWKLGVAKQLAWAMHFLEE-KSLIHGNVCAKNILLIREEDRRTGNP JAK1_Mmus -NKN----KI--NLKQQLKYAIQICKGMDYLGS-RQYVHRDLAARNVLVESEH------- JAK1~b_Mmus -KSD----AL--TTPWKFKVAKQLASALSYLED-KDLVHGNVCTKNLLLAREGID-SDIG TYK2_Mmus -H------CV--GLAQLLLFAQQICEGMAYLHA-QHYIHRDLAARNVLLDNDR------- TYK2~b_Mmus -QRG----QV--PMTWKMVVAQQLASALSYLED-KNLVHGNVCGRNILLARLGLE-EGTN JAK1_Spur -KKD----RV--SHKTLYLFGQQICQGMKYLHEERMMVHRDLAARNVLVSNEN------- JAK1~b_Spur -VKAVNKKDLSHSEDWVMFFAIKILQVVEYMHR-CKIIHGDVKPDNFL------------ JAK2_Spur NERK----RL--GLNSQLHAAFQLIDALEYLES-RRIVHGNVSAHNTLVLRPAP-----N JAK2~b_Spur NERK----RL--GLNSQLHAAFQLIDALEYLES-RRIVHGNVSAHNTLVLRPAP-----N : : : :: * : : TYK2_Hsap -LVKIGDFGLAKAVPEGHEYYRVREDG-DSPVFWYAPE---CLKEY-K-FYYASDVWSFG TYK2~b_Hsap PFIKLSDPGVGLGALSREE-------R-VERIPWLAPE---CLPGGANSLSTAMDKWGFG JAK3_Hsap -HVKIADFGLAKLLPLDKDYYVVREPG-QSPIFWYAPE---SLSDN-I-FSRQSDVWSFG JAK3~b_Hsap PFIKLSDPGVSPAVLSLEM-------L-TDRIPWVAPE---CLREA-QTLSLEADKWGFG JAK2_Hsap -RVKIGDFGLTKVLPQDKEYYKVKEPG-ESPIFWYAPE---SLTES-K-FSVASDVWSFG JAK2~b_Hsap PFIKLSDPGISITVLPKDI-------L-QERIPWVPPE---CIENP-KNLNLATDKWSFG JAK1_Hsap -QVKIGDFGLTKAIETDKEYYTVKDDR-DSPVFWYAPE---CLMQS-K-FYIASDVWSFG JAK1~b_Hsap PFIKLSDPGIPITVLSRQE-------C-IERIPWIAPE---CVEDS-KNLSVAADKWSFG hop_Dmel LDAKISDPGYPRPY-------RESD------SPWIPVKYYRNLQAA-K-TDQFAQLWAFA hop~b_Dmel DCVKISDFGLAQFANSD-GYYYAKSKR-DIPIRWYSPE---AISTC-R-FSSYSDVWSYG JAK3_Mmus -HVKIADFGLAKLLPLGKDYYVVREPG-QSPIFWYAPE---SLSDN-I-FSRQSDVWSFG JAK3~b_Mmus PFIKLSDPGVSPTVLSLEM-------L-TDRIPWVAPE---CLQEA-QTLCLEADKWGFG JAK2_Mmus -RVKIGDFGLTKVLPQDKEYYKVKEPG-ESPIFWYAPE---SLTES-K-FSVASDVWSFG JAK2~b_Mmus PFIKLSDPGISITVLPKDI-------L-QERIPWVPPE---CIENP-KNLNLATDKWSFG JAK1_Mmus -QVKIGDFGLTKAIETDKEYYTVKDDR-DSPVFWYAPE---CLIQC-K-FYIASDVWSFG JAK1~b_Mmus PFIKLSDPGIPVSVLTRQE-------C-IERIPWIAPE---CVEDS-KNLSVAADKWSFG TYK2_Mmus -LVKIGDFGLAKAVPEGHEYYRVREDG-DSPVFWYAPE---CLKEC-K-FYYASDVWSFG TYK2~b_Mmus PFIKLSDPGVGQGALSREE-------R-VERIPWTAPE---CLSGGTSSLGTATDMWGFG JAK1_Spur -EVKITDFGLARIFGTEKDYYRAKESSQKVPIKWYAPE---WLRHQ-K-YQKESDVWSLG JAK1~b_Spur ------------------------------------------------------------ JAK2_Spur MHIKLADPMLGVYYHSLEM---TSRPK-LERVRWTAPE---LLATN-SEPTLAGDKFSYA JAK2~b_Spur MHIKLADPMLGVYYHSLEM---TSRPK-LERVRWTAPE---LLATN-SEPTLAGDKFSYA TYK2_Hsap VTLYELLTHCDSSQSPPTKFLELIGIA-QGQMTVLRLTELLERGERLPRPDKCPCEVYHL TYK2~b_Hsap ATLLEICFDGEAPLQSRS---------------PSEKEHFYQRQHRLPEPS-C-PQLATL JAK3_Hsap VVLYELFTYCDKSCSPSAEFLRMMGCER-DVPALCRLLELLEEGQRLPAPPACPAEVHEL JAK3~b_Hsap ATVWEVFSGVTMPISALD---------------PAKKLQFYEDRQQLPAPK-W-TELALL JAK2_Hsap VVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMI JAK2~b_Hsap TTLWEICSGGDKPLSALD---------------SQRKLQFYEDRHQLPAPK-W-AELANL JAK1_Hsap VTLHELLTYCDSDSSPMALFLKMIGPT-HGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQL JAK1~b_Hsap TTLWEICYNGEIPLKDKT---------------LIEKERFYESRCRPVTPS-C-KELADL hop_Dmel TTIYEIFSRCKEDLSTLRQE------------QLLRQKNLDGNILKMLDQDICPAPIFET hop~b_Dmel VTLFEMFSRGEEPNLVPIQT------------SQEDFLNRLQSGERLNRPASCPDFIYDL JAK3_Mmus VVLYELFTYCDKSCSPSAEFLSMMGPER-EGPPLCRLLELLAEGRRLPPPPTCPTEVQEL JAK3~b_Mmus ATTWEVFSGGPAHITSLE---------------PAKKLKFYEDQGQLPALK-W-TELAGL JAK2_Mmus VVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELLKSNGRLPRPEGCPDEIYVI JAK2~b_Mmus TTLWEICSGGDKPLSALD---------------SQRKLQFYEDKHQLPAPK-W-TELANL JAK1_Mmus VTLHELLTYCDSDFSPMALFLKMIGPT-HGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQL JAK1~b_Mmus TTLWEICYNGEIPLKDKT---------------LIEKERFYESRCRPVTPS-C-KELADL TYK2_Mmus VTLYELLTYCDSNQSPHMKFTELIGHT-QGQMTVLRLTELLERGERLPRPDRCPCEIYHL TYK2~b_Mmus ATLLEICFDGEAPLQGRG---------------PSEKERFYTKKHQLPEPS-S-PELATL JAK1_Spur IVLWEMFSYGQDPIYQDSKGR---------RVEHIELLDFFEKGMRLTHPPSCPAAIETM JAK1~b_Spur ------------------------------------------------------------ JAK2_Spur ITLWQIMSHGAIPAENLS---------------DExxxxxYRHGVRLDAPPGCPQELLKI JAK2~b_Spur ITLWQI------------------------------------------------------ TYK2_Hsap MKNCWETEASFRPT-----------------------F TYK2~b_Hsap TSQCLTYEPTQRPSFRTILRD----------------L JAK3_Hsap MKLCWAPSPQDRPSFSALGPQL--------------DM JAK3~b_Hsap IQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTP JAK2_Hsap MTECWNNNVNQRPSFRDLALRVD-------------QI JAK2~b_Hsap INNCMDYEPDFRPSFRAIIRDLNS------------LF JAK1_Hsap MRKCWEFQPSNRTSFQNLIEGFE-------------AL JAK1~b_Hsap MTRCMNYDPNQRPFFRAIMRDIN--------------K hop_Dmel IMDGWSDDETKRFSHHDIFS----------------RL hop~b_Dmel MQLCWHATPRSRPSFATIV-----------------DI JAK3_Mmus MQLCWAPSPHDRPAFGTLSPQL--------------DA JAK3~b_Mmus ITQCMAYDPGRRPSFRAILRDLNGLITSDYELLSDPTP JAK2_Mmus MTECWNNNVSQRPSFRDLSLRVD-------------QI JAK2~b_Mmus INNCMDYEPDFRPAFRAVIRDLNS------------LF JAK1_Mmus MRKCWEFQPSNRTTFQNLIEGFE-------------AL JAK1~b_Mmus MTRCMNYDPNQRPFFRAIMRDIN--------------K TYK2_Mmus MKNCWETEASFRPT-----------------------F TYK2~b_Mmus TRQCLTYEPAQRPSFRTILRD----------------L JAK1_Spur MNDCWEMDPLKRPKFQSMIVRLG-------------IL JAK1~b_Spur -------------------------------------I JAK2_Spur MEACWSHNPRNRPSCRGVLRDVNSF-----------LS JAK2~b_Spur -------------------------------------M