CLUSTAL W (1.83) multiple sequence alignment TESK2_Hsap_TESK FT-CEKIGSGFFSEVFKVRHRASGQVMAL--KMNTL------SSNRANMLKEVQLMNRL- TESK1_Hsap_TESK FHCAEKIGAGFFSEVYKVRHRQSGQVMVL--KMNKL------PSNRGNTLREVQLMNRL- LIMK2_Hsap_LIMK LIHGEVLGKGFFGQAIKVTHKATGKVMVM--KELIRC----DEETQKTFLTEVKVMRSL- LIMK1_Hsap_LIMK LIHGEVLGKGCFGQAIKVTHRETGEVMVM--KELIRF----DEETQRTFLKEVKVMRCL- LIMK1_Dmel_LIMK LVIGEKLGEGFFGKVFKVTHRQSGEVMVL--KELHRA----DEEAQRNFIKEVAVLRLL- cdi_Dmel_TESK V--KEKIGSGFFSEVYKVTHRTTGQVMVL--KMNQL------RANRPNMLREVQLLNKL- LIMK2_Mmus_LIMK LIHGEVLGKGFFGQAIKVTHKATGKVMVM--KELIRC----DEETQKTFLTEVKVMRSL- LIMK1_Mmus_LIMK LIHGEVLGKGCFGQAIKVTHRETGEVMVM--KELIRF----DEETQRTFLKEVKVMRCL- TESK1_Mmus_TESK FDCAEKIGAGFFSEVYKVRHRQSGQVMVL--KMNKL------PSNRSNTLREVQLMNRL- TESK2_Mmus_TESK FT-REKIGSGFFSEVFKVRHRASGQVMAL--KMNTL------SSNRANLLKEMQLMNRL- DDB0229851_Ddis_LISK-DD1 -----IIGSGGFGKVYQGVLNGK-EIGIKKI--TISDNDPNRDILLKFLEREIYTLKML- DDB0229853_Ddis_LISK-DD1 -----EIGRGSFGQVQKASYFGT-DVAVKQL--STLVSI--DPDYFKFMLREIKILKGM- DDB0229854_Ddis_LISK-DD1 LEFNEKIGKGSFGSVFRGCYLGL-DVAIKKI--EKA--D--DPEYLKYIDREVSMLQSL- DDB0229863_Ddis_LISK-DD1 --VGNEIGSGKYGSVSLGYWLGT-PVAIKKL--H-EN----NEETEILVQRELQILKEI- DDB0229865_Ddis_LISK-DD1 -----EFSKGSFAKVYKGSYYGN-PVCVKVIKKDTLIDKE----SWVFLKREIGILKNLL DDB0229866_Ddis_LISK-DD1 ----QEIGKGAYGKIFKGEYFGT-PVAIKEI--SLQPNDVKYKDLTKFIQREVAML-RF- DDB0229867_Ddis_LISK-DD1 LVFKDIIGKGNFGCVYRGNYLGV-EVAIKQI--PSF--D--DPDYCKYTEREVKALRYI- KinX_Ddis_LISK-DD1 LDFISEIGSGGFGKVFKGEYLGA-PVAIKKI--HILPDDPNRVDLEKFLNREIETIKLF- KinY_Ddis_LISK-DD1 LKVGESIGSGAYGIVYRGTLFNS-DVAIKKI--QNEKSE--KNEFIKYLKREVAVLKNI- LIMK_Spur_LIMK LIKGEVLGQGFFGKAVKVTHRYTGEVMVI--KELVRY----SDSAQRDFLKEVKVLRSL- Tesk_Spur_TESK ----------------KIRHKADGRVMVA--KIGKQKI---WRANQHKMIQELELLNKL- CC1G_09729_Ccin_LISK-DD1 --DWKKLGSGSFGNVYKGSYLGI-DVAIKEV--LPSN----DYDVAKYFEREWRLMKEC- AqueK481_Aque_LIMK LIIGEVLGHGFYGNVIKVTHRYTEQVMVM--KEMRNC----TEEAKKTFRKEVAVLKRL- AqueK482_Aque_TESK FT-REKIGQGFFAEVFKVTHKNTGEVMVL--KLNKS------RNNSKQMLAEIQLLNRL- AqueK483_Aque_TESK FERIEKIGSGFFAEVYKVRHKLTDEIMVL--KVNKG------L-TGTKTRQEVELLKRL- AqueK484_Aque_TESK FERIEKIGSGFFADVYKVRRKLTNQIMVL--KVNKG------L-TATKTRQEVELLKRL- : * : TESK2_Hsap_TESK --SHPNILRFMGVCVH-------------QGQ-LHALTEYINSGNLEQLLDS-N------ TESK1_Hsap_TESK --RHPNILRFMGVCVH-------------QGQ-LHALTEYMNGGTLEQLLSS-P------ LIMK2_Hsap_LIMK --DHPNVLKFIGVLYK-------------DKK-LNLLTEYIEGGTLKDFLRSM------- LIMK1_Hsap_LIMK --EHPNVLKFIGVLYK-------------DKR-LNFITEYIKGGTLRGIIKSMD------ LIMK1_Dmel_LIMK --DHRHVLKFIGVLYK-------------DKK-LHMVTEYVAGGCLKELIHDPA------ cdi_Dmel_TESK --SHANILSFMGVCVQ-------------EGQ-LHALTEYINGGSLEQLLANKE------ LIMK2_Mmus_LIMK --DHPNVLKFIGVLYK-------------DKK-LNLLTEYIEGGTLKDFLRSV------- LIMK1_Mmus_LIMK --EHPNVLKFIGVLYK-------------DKR-LNFITEYIKGGTLRGIIKNMD------ TESK1_Mmus_TESK --RHPNILRFMGVCVH-------------QGQ-LHALTEYMNGGTLEQLLSS-P------ TESK2_Mmus_TESK --SHPNILRFMGVCVH-------------QGQ-LHALTEYINSGNLEQLLDS-D------ DDB0229851_Ddis_LISK-DD1 --SHPNVIKFYGIAEK-------------ERS-LFLLTELVSGGDLHWYIKNKS------ DDB0229853_Ddis_LISK-DD1 --RHPNIVQYIGACCH-------------EGR-YMIVTEYIKGGDLHQFIKARG------ DDB0229854_Ddis_LISK-DD1 --RHPFIVNFSGICVH-------------SSG-LYIVTEFVSGGDVRQLLKK-T------ DDB0229863_Ddis_LISK-DD1 --RHPQIVQFLGVSRN------------EKDE-IHIITEFMDGGDLFDALIFGD------ DDB0229865_Ddis_LISK-DD1 NQGHKNIIRFIGIGEK-------------DSL-LFLVTELINGGDLGNILLDHK------ DDB0229866_Ddis_LISK-DD1 --SHPNLVQFIGVSER-------------GSS-LYIVTEFVQGGDLAYYLFRNKFDDTPE DDB0229867_Ddis_LISK-DD1 --RHPFVVHFFGACKH-------------ESG-FYLITEFIEGLDLRRYLKSVP------ KinX_Ddis_LISK-DD1 --THPNVIQFVGISEN-------------NGI-LFIVTELIEGGDLQYYLKNQS------ KinY_Ddis_LISK-DD1 --QHPNIVQFIGVYYEPLASPSLVNRLLNSSS-TWIVTEYIGGGNLHERIKDTK------ LIMK_Spur_LIMK --DHYHVLKFIGVLYR-------------DKR-LNLVTEFVGGGTLENIISDLD------ Tesk_Spur_TESK --QHPNVVRYMGACVK-------------DGH-IHPVLEYVSGGCLTDILADES------ CC1G_09729_Ccin_LISK-DD1 --RHPNICLFIGLSRAP----------PPDNR-IFIVSEFIEGGNVRLYIHDKN------ AqueK481_Aque_LIMK --HHPNLLKFIGILYQ-------------EDKLLTLITEFIGGGTLRKRIKKKD------ AqueK482_Aque_TESK --SHSNILGFKGSCVH-------------EGS-LHALTEYINGGTLEELLSS-D------ AqueK483_Aque_TESK --HHPNILHYIGSCIH-------------NGQ-LHPLTEFVNGGTLKSLIQDVE------ AqueK484_Aque_TESK --NHPNILHYIGSCIH-------------NEQ-LHPLTEFVNGGTLKSLIQDVE------ * : : * : * : . : : TESK2_Hsap_TESK ----------------------------LHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDL TESK1_Hsap_TESK ----------------------------EPLSWPVRLHLALDIARGLRYLHSKGVFHRDL LIMK2_Hsap_LIMK ----------------------------DPFPWQQKVRFAKGIASGMAYLHSMCIIHRDL LIMK1_Hsap_LIMK ----------------------------SQYPWSQRVSFAKDIASGMAYLHSMNIIHRDL LIMK1_Dmel_LIMK ----------------------------QVLPWPQRVRLARDIACGMSYLHSMNIIHRDL cdi_Dmel_TESK ----------------------------VVLSATQKIRLALGIARGMSYVHDAGIFHRDL LIMK2_Mmus_LIMK ----------------------------DPFPWQQKVRFAKGISSGMAYLHSMCIIHRDL LIMK1_Mmus_LIMK ----------------------------SQYPWSQRVSFAKDIASGMAYLHSMNIIHRDL TESK1_Mmus_TESK ----------------------------EPLSWPVRLHLALDIAQGLRYLHAKGVFHRDL TESK2_Mmus_TESK ----------------------------LYLPWTVRVKLAYDIAVGLSYLHFKGIFHRDL DDB0229851_Ddis_LISK-DD1 ----------------------------IDITWKLKVKIARDIAASMAYLHENGVIHRDL DDB0229853_Ddis_LISK-DD1 ---------------------------VSNISWTLRMKLALDIASAFSYLHSKKVIFRDL DDB0229854_Ddis_LISK-DD1 ----------------------------PPIGWDKRVSIAVDLAKAMVFLHAKKIIHRDL DDB0229863_Ddis_LISK-DD1 ----------------------------IPLTWKEKLRISLDIAQSCRFLHARGILHRDL DDB0229865_Ddis_LISK-DD1 ----------------------------FHIPWSLRVKIAKDIAEGMEYLHSKQIMHRDL DDB0229866_Ddis_LISK-DD1 QYIHRKVNVGSSSTPDLSDPTVHNGEKLVQLAWPLRIKIAYDVACAMAYLHSRNVIHRDL DDB0229867_Ddis_LISK-DD1 ----------------------------KPPKWLSRVNIALGVAKTFLFLHSKNLLHRDL KinX_Ddis_LISK-DD1 ----------------------------IDLPWFLRANIALDVSLAMSYLHSKSIVHRDL KinY_Ddis_LISK-DD1 ----------------------------KDFPIELRIKLSLDIALAMAYLHSRDIIFRDL LIMK_Spur_LIMK ----------------------------KPFPWLQRINAARDIASGMSYLHSMGIIHRDL Tesk_Spur_TESK ----------------------------LALSWRQKGDLATDIARGMTYLHSQNVCHRDL CC1G_09729_Ccin_LISK-DD1 ----------------------------KPFPWRLRMSFATDVARALAYLHARKCIHRDL AqueK481_Aque_LIMK ----------------------------VPFPWKLRIQIALDISAGMN------------ AqueK482_Aque_TESK ----------------------------PHLSWSKRIKIAHDIANGMAYLHNRGVFHRDL AqueK483_Aque_TESK ---------------------------KNPFPPEQRIQLSLDMAMGMEYLHNNGMLHRDF AqueK484_Aque_TESK ---------------------------KNPFPREQRIQLSLDMALGMEYLHENGMLHRDF : : .:: TESK2_Hsap_TESK TSKNCLIKRDEN-GYSAVVADFGLAEKIPDVS---------------------------- TESK1_Hsap_TESK TSKNCLVRREDR-GFTAVVGDFGLAEKIPVYR---------------------------- LIMK2_Hsap_LIMK NSHNCLIKLD----KTVVVADFGLSRLIVEERKRA------------------------- LIMK1_Hsap_LIMK NSHNCLVREN----KNVVVADFGLARLMVDEKTQP------------------------- LIMK1_Dmel_LIMK NSMNCLVRED----RSVIVADFGLARSVDAPRLPSGNM--TPGGY--------------- cdi_Dmel_TESK TSKNVLIRNLANDQYEAVVGDFGLAAKIPVK----------------------------- LIMK2_Mmus_LIMK NSHNCLIKLD----KTVVVADFGLSRLIVEERKRP------------------------- LIMK1_Mmus_LIMK NSHNCLVREN----RNVVVADFGLARLMIDEKNQS------------------------- TESK1_Mmus_TESK TSKNCLVRREDR-GFTAVVGDFGLAEKIPVYR---------------------------- TESK2_Mmus_TESK TSKNCLIKRDEN-GYSAVVADFGLAEKIPDAS---------------------------- DDB0229851_Ddis_LISK-DD1 KSTNLLVAENW----VIKVCDMGLARKMDK------------------------------ DDB0229853_Ddis_LISK-DD1 KAKNILVDEIGDGLYRAKVIDFGFARIFDGK----------------------------- DDB0229854_Ddis_LISK-DD1 KSKNILLDEFQ----RIRLCDFGFARMSEQT----------------------------- DDB0229863_Ddis_LISK-DD1 KSQNILLSTNR----RAKLCDLGLARMFEE------------------------------ DDB0229865_Ddis_LISK-DD1 KSNNLLLGRNW----TIKICDFGFAKEITI------------------------------ DDB0229866_Ddis_LISK-DD1 KSTNLLVGDNW----RIKVCDMGFARTAQVGGG--------------------------- DDB0229867_Ddis_LISK-DD1 KSKNILLDISRN---QIKLCDFGFARVGSQYSNGSDS-SSSEDESDSECVNGAAGGGGDD KinX_Ddis_LISK-DD1 KSTNLLVDKNW----KIKVCDFGFARIVEE------------------------------ KinY_Ddis_LISK-DD1 KSKNILIDDSSS-PIRGKVCDFGFARILNKKQ---------------------------- LIMK_Spur_LIMK NSNNCLVRDD----GSVVVADFGLARVFIDENDSRC------------------------ Tesk_Spur_TESK TSANCLVRQKPNNVLEAILTDFGLARVLGCMPDPPPNSPRTPESP--------------- CC1G_09729_Ccin_LISK-DD1 KGENLLVTSNG----RIKVTDFGFARIAARNE---------------------------- AqueK481_Aque_LIMK --------------SRAVVADFGLARVFYPLDFSN------------------------- AqueK482_Aque_TESK TSKNCLIQKSDDGSLNCVVADFGLAAKIV------------------------------- AqueK483_Aque_TESK NSHNCLLRKEGD-RYTAVVADFGLATKNPNLI---------------------------- AqueK484_Aque_TESK NSNNCLLRKEGD-RYTAVVADFGLAAKNPNLM---------------------------- : *:*:: TESK2_Hsap_TESK ----------------------------MGSEKLAVVGSPFWMAPEVLRDEPYNEKADVF TESK1_Hsap_TESK --------------------------EGARKEPLAVVGSPYWMAPEVLRGELYDEKADVF LIMK2_Hsap_LIMK -------------PMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIF LIMK1_Hsap_LIMK -------------------EGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVF LIMK1_Dmel_LIMK -----GSGANSDAPMSPS-GTLRRSKSRQRRQRYTVVGNPYWMAPEMMKGLKYDEKLDVF cdi_Dmel_TESK ----------------------------SRKSRLETVGSPYWVSPECLKGQWYDQTSDVF LIMK2_Mmus_LIMK -------------PVEKATTKKRTLRKSDRKKRYTVVGNPYWMAPEMLNGKSYDETVDVF LIMK1_Mmus_LIMK -------------------EDLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVF TESK1_Mmus_TESK --------------------------EGTRKEPLAVVGSPYWMAPEVLRGELYDEKADVF TESK2_Mmus_TESK ----------------------------IGREKLAVVGSPFWMAPEVLRDEPYNEKADVF DDB0229851_Ddis_LISK-DD1 ----------------------------SEKSKMTICGTDDWMAPEVLIGEEYDASCDVF DDB0229853_Ddis_LISK-DD1 -----------------------------DTNNLTICGSENTMSPEVIVGSSYNDSCDVY DDB0229854_Ddis_LISK-DD1 ----------------------------KKSRHMTMCGTEGWVAPEILLGMSYDTSCDVF DDB0229863_Ddis_LISK-DD1 ----------------------------RINKRYTCVGTEIWMAPEVCLDQSYSTAVDVF DDB0229865_Ddis_LISK-DD1 ----------------------------QNPLSMTICGTDEFMSPEVILGIQYSYSADIY DDB0229866_Ddis_LISK-DD1 ---------------------------SRAKRTMTICGTTNCMAPEVVLGQDYNEACDVF DDB0229867_Ddis_LISK-DD1 VYKNNG--------------NG--KPANYRLRRMSICGTPSFMPPEILLQQKYDWSVDVF KinX_Ddis_LISK-DD1 ----------------------------DNNKSMTICGTDNWMSPEMITGLDYDERSDIF KinY_Ddis_LISK-DD1 ----------------------------QGNRHLSICGTDSIMAPELILGMEYDESVDIF LIMK_Spur_LIMK -------------PNSF-GPGRDKHQPAGRKKRYTMVGTAFWMAPEMLKGKDYNERVDVF Tesk_Spur_TESK ------EPDIIDAPNGGPMLPRIPSACMDVPRKMSVVGTAFWMAPEVLRGEEYTRQVDVF CC1G_09729_Ccin_LISK-DD1 ----------------------------EELRRLTFCGTDSYMSPEILLGDEFDLPTDVF AqueK481_Aque_LIMK ----------------------DKSKKRNNRSRMTVVGSPYWMAPEMLKGQDYDETVDIF AqueK482_Aque_TESK ------------------------------------------------------------ AqueK483_Aque_TESK --------------------------K-KLRRNQSMVGTPYWMAP--------------- AqueK484_Aque_TESK --------------------------K-DLRCNQSVVGTPFWMAPEVLHGKRYDKKADTY TESK2_Hsap_TESK SYGIILCEIIARIQADPDYLPRTE--NFGLDYDAFQH---MV-GDCPPDFLQLTFNCCNM TESK1_Hsap_TESK AFGIVLCELIARVPADPDYLPRTE--DFGLDVPAFRT---LVGDDCPLPFLLLAIHCCNL LIMK2_Hsap_LIMK SFGIVLCEIIGQVYADPDCLPRTL--DFGLNVKLFWE--KFVPTDCPPAFFPLAAICCRL LIMK1_Hsap_LIMK SFGIVLCEIIGRVNADPDYLPRTM--DFGLNVRGFLD--RYCPPNCPPSFFPITVRCCDL LIMK1_Dmel_LIMK SFGIMLCEIIGRVEADPDFMPRNS--DFSLNQQEFRE--K-FCAQCPEPFVKVAFVCCDL cdi_Dmel_TESK SFGIIQCEIIARIEADPDMMPRTA--SFGLDYLAFVE---LCPMDTPPVFLRLAFYCCLY LIMK2_Mmus_LIMK SFGIVLCEIIGQVYADPDCLPRTL--DFGLNVKLFWE--KFVPTDCPPAFFPLAAICCKL LIMK1_Mmus_LIMK SFGIVLCEIIGRVNADPDYLPRTM--DFGLNVRGFLD--RYCPPNCPPSFFPITVRCCDL TESK1_Mmus_TESK AFGIVLCELIARVPADPDYLPRTE--DFGLDVPAFRT---LVGNDCPLPFLLLAIHCCSM TESK2_Mmus_TESK SYGIILCEIIARIQADPDYLPRTE--NFGLDYDAFQN---MV-GDCPSDFLQLTFNCCNM DDB0229851_Ddis_LISK-DD1 SFGMVLIELITRENLTPR--IRNE--DLGVDQKFFLS---KVPADCPKELLRLVSECCKV DDB0229853_Ddis_LISK-DD1 SYGVLLLELICGSRVVKTQLKRTPMNAFDMNLEKAEHL---APESCPRAFMDLAKWCCSY DDB0229854_Ddis_LISK-DD1 SYGVVLAELITGRKPGVDLWVRSPETCFDINPEELKQK---SIPGCPSELISVCVECCLY DDB0229863_Ddis_LISK-DD1 SFGIVLVEIITEKIPDE--RFPQ--HRFQFDAPAFLK---KVPKECPPDFSKLCVDCTKY DDB0229865_Ddis_LISK-DD1 SFGMVLLELITRSKLDER--LPQN--NFDIDYEELQN---KIPSECPREFLELSMKCCNY DDB0229866_Ddis_LISK-DD1 SYGIVLSEIITRMDTTNNLRPSSL--KYGLDVDVLLP---LVPKDCPPPFLKLVLDCTEY DDB0229867_Ddis_LISK-DD1 SFGILCTELITLKRPGKDYWVRSQNNGFDINIEELNVN-IPSPNDCPIQFYDLALKCCSY KinX_Ddis_LISK-DD1 SFGIVLLEIISRVKPAPY--MRDA--SFGLAEDIVRNQ--LIPTDCPESLIDLTFNCCSV KinY_Ddis_LISK-DD1 SFGVVLLEMILRKKVSK-VLERGPQSAFEIDQDSARQL---IPDDIPVLYSDLALDCIKY LIMK_Spur_LIMK SFGIVMCELIGRVSACPDDLPRSG--DFGLDEVPFMA--Q-CCDTCPKTFHQIMLMCVRM Tesk_Spur_TESK SFGIVVCEIVARITANPDDLPRTG--KFGLDLQLFKE---KC-PGIPEPFLQIAEDCCSM CC1G_09729_Ccin_LISK-DD1 SLGIIFCEIAARRLADDRHFKRHP-PTFGIDPEEVRK---LATPGCPEDFLKLCLDCLNT AqueK481_Aque_LIMK SFGIVLCEIISRVKSDPDELPRLN--SFGLDELKFRE---MR-GDCPLLFYNLAVQCTSL AqueK482_Aque_TESK ------------------------------------------------------------ AqueK483_Aque_TESK ------------------------------------------------------------ AqueK484_Aque_TESK SYGIVLCEIVSRKDADPDEIPRND--NFSLNEAAFRELPEVIGSPCPPAFIDLACNCSKF TESK2_Hsap_TESK DPKLRPSFVEIGK------------------------------------TL TESK1_Hsap_TESK EPSTRAPFTEITQHL---------------------------------EWI LIMK2_Hsap_LIMK EPES----------------------------------------------R LIMK1_Hsap_LIMK DPEKRPSFVKLEHW------------------------------------L LIMK1_Dmel_LIMK NPDMRPCFETLHVW------------------------------------L cdi_Dmel_TESK DAKSRPTFHDATKKL----------------------------------TL LIMK2_Mmus_LIMK EPES----------------------------------------------R LIMK1_Mmus_LIMK DPEKRPSFVKLEQW------------------------------------L TESK1_Mmus_TESK EPSTRAPFTEITQHL---------------------------------EQI TESK2_Mmus_TESK DPKLRPSFEEIGK------------------------------------TL DDB0229851_Ddis_LISK-DD1 APSGRP--------------------------------------------S DDB0229853_Ddis_LISK-DD1 NPKDRPTF------------------------------------------K DDB0229854_Ddis_LISK-DD1 EPLTRPKFDEILS------------------------------------QL DDB0229863_Ddis_LISK-DD1 NPKERPSFIKVLD------------------------------------TI DDB0229865_Ddis_LISK-DD1 DPNDRPSFTDIVQ------------------------------------TL DDB0229866_Ddis_LISK-DD1 DPDNRPTFKEITERLK---------------------------------SL DDB0229867_Ddis_LISK-DD1 KHTNRPMFSTIVTILES-------------------------------IKL KinX_Ddis_LISK-DD1 DPNNRPSFKEISQ------------------------------------TL KinY_Ddis_LISK-DD1 QPEERPNFSHIIHVLKQLTSLFPVVHTFDNPLSPTSSPITPRKNSLNSPFT LIMK_Spur_LIMK DSDERPSFDELDQRLSSF-----------------------------SLHF Tesk_Spur_TESK DPRDRPVFAELVR------------------------------------RF CC1G_09729_Ccin_LISK-DD1 EPARRPGTREILDRL----------------------------------RL AqueK481_Aque_LIMK NPEERPLFLDIRKGLS--------------------------------HYI AqueK482_Aque_TESK --------------------------------------------------D AqueK483_Aque_TESK --------------------------------------------------E AqueK484_Aque_TESK VPDERPG-------------------------------------------F