CLUSTAL W (1.83) multiple sequence alignment MNK2_Hsap_MNK -QLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG-HIRSRVFREVEMLYQCQGHRN MNK1_Hsap_MNK YKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAG-HSRSRVFREVETLYQCQGNKN MAPKAPK5_Hsap_MK5 -INWTQKLGAGISGPVRVCVKKSTQERFALKILLDR------PKARNEVRLHMMCATHPN MAPKAPK3_Hsap_MK2 -QLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDS------PKARQEVDHHWQASGGPH MAPKAPK2_Hsap_MK2 -KVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDC------PKARREVELHWRASQCPH MAPk-Ak2_Dmel_MK2 -VTSNTVLGYGINGKVVQCTHRRTQQNYALKVLLDS------ERARREVDLHWRVSGCRY Lk6_Dmel_MNK YKLTGEILGEGAYASVQTCVNIYTDLEYAVKVIDKIPG-HARARVFREVETFHHCQGHLG MNK2_Mmus_MNK -QLQEDVLGEGAHARVQTCVNLITNQEYAVKIIEKQLG-HIRSRVFREVEMLYQCQGHRN MNK1_Mmus_MNK YQLTSELLGEGAYAKVQGAVNLQSGKEYAVKIIEKQAG-HSRSRVFREVETLYQCQGNRN MAPKAPK5_Mmus_MK5 -INWTQKLGAGISGPVRVCVKKSTQERFALKILLDR------PKARNEVRLHMMCATHPN MAPKAPK3_Mmus_MK2 -QLSKQVLGLGVNGKVLECYHRRSGQKCALKLLYDS------PKARQEVDHHWQASGGPH MAPKAPK2_Mmus_MK2 -KVTSQVLGLGINGKVLRIFDKRTQQKFALKMLQDC------PKARREVELHWRASQCPH R166.5_Cele_MNK YKLTDEHLGSGAYGSVTTCKSIKSGVEYAVKIVDKQGETHSRKRILREVNIFKTCKDHPN K08F8.1_Cele_MK2 YTISAEIIGIGESGKVMACYQKVTGEKFALKVLRDS------QKARREVELHWLTNAHEN C44C8.6_Cele_MK2 -RISRKVLGVGINGKVVECEHRQSGDKFALKVLRDT------QKARREVELHVMASGHGH MAPKAPK2_Spur_MK2 ------------------------------------------------------------ MAPKAPK5a_Spur_MK2 ---------------VRPCQHKRSEDRFALKLLLDK------PGARAEVNLHSRCSGHAN MAPKAPK5b_Spur_MK5 ------------------------------------------------------------ Mnk_Spur_MNK ----GELLGSGSYASVRTCRQISSGKEYAVKMMEKRPG-NSRTKIFREVETLYHCQGHNN AqueK073_Aque_MK2 -TILTRSLGVGVNGKVLECIHKATGERRALKILREN------PKSRRELDLHWRSCSHEN AqueK074_Aque_MK5 -IKWNRSLGTGVSGPVRLCIHRATGKEYALKLLLDRSD---RKKAEIEATLHWRCSGGDH AqueK075_Aque_MNK YELTSEILGSGARATVITCIKRTTRQQYAAKIINNSGP-EVRDRVLKEVEILYSCSSCDN MNK2_Hsap_MNK VLELIEFFEEE----------DRFYLVFEKMRGGSILSHIHKR--RHFNELEASVVVQDV MNK1_Hsap_MNK ILELIEFFEDD----------TRFYLVFEKLQGGSILAHIQKQ--KHFNEREASRVVRDV MAPKAPK5_Hsap_MK5 IVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQH--RHFTEKQASQVTKQA MAPKAPK3_Hsap_MK2 IVCILDVYENMHH------GKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDI MAPKAPK2_Hsap_MK2 IVRIVDVYENLYA------GRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI MAPk-Ak2_Dmel_MK2 IVNIIDVYENTFK------DRKCLLVVMECMEGGELFQRIQDKADGAFTEREAAQIMHEI Lk6_Dmel_MNK ILQLIEFFEDD----------EKFYLVFEKINGGPLLSRIQEH--ICFSEHEASQIIKEI MNK2_Mmus_MNK VLELIEFFEEE----------DRFYLVFEKMRGGSILSHIHRR--RHFNELEASVVVQDV MNK1_Mmus_MNK ILELIEFFEDD----------TRFYLVFEKLQGGSILAHIQKR--KHFNEREASRVVRDV MAPKAPK5_Mmus_MK5 IVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQH--RHFTEKQASQVTKQI MAPKAPK3_Mmus_MK2 IVRILDVYENMHH------GKRCLLIVMECMEGGELFSRIQERGDQAFTEREAAEIMRDI MAPKAPK2_Mmus_MK2 IVHIVDVYENLYA------GRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSI R166.5_Cele_MNK IVQLLDWFEDE----------TNFYLVMEKMRGGPLLQHILQR--KYFTEEEARRVTKDI K08F8.1_Cele_MK2 VVSILDIYENTFD------NVKCLLMVVEFLEGGDLLSQFESQGSIPYTEKKVGEIIRQI C44C8.6_Cele_MK2 VVSVHDVYKNSYN------GVDCLLVVMENMKGGELFNRIQERGQKAFTEREAAGIVNEI MAPKAPK2_Spur_MK2 -----------------------------------------------------------I MAPKAPK5a_Spur_MK2 IVKIIEVFSNEVQFPGEPAPKSRLLVVMELMDGGELFDRISKQ--KRFTERQAVILTKQI MAPKAPK5b_Spur_MK5 ------------------------------------------------------------ Mnk_Spur_MNK ILQLIEYFEDD----------DRFYLIFEKMYGGALLQHIEQR--GTFTEQEASQVIRDI AqueK073_Aque_MK2 IVNICDVYENVFM------GHRSLLVVMECMEGGELFDRIQDK--GHFTEREAAEVVRCI AqueK074_Aque_MK5 IVRIVDIYRNEIQQPGELSPKKRILLVMELMEGKELFDYISKR--HHFTEHEASKYILQI AqueK075_Aque_MNK FLKIEDFFETS----------EKFYLVFEKMEG-PLLELIQKR--ERFTEREASEVTREV MNK2_Hsap_MNK ASALDFLHNK-----------------------------------------GIAHRDLKP MNK1_Hsap_MNK AAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKP MAPKAPK5_Hsap_MK5 TLALRHCHLL-----------------------------------------NIAHRDLKP MAPKAPK3_Hsap_MK2 GTAIQFLHSH-----------------------------------------NIAHRDVKP MAPKAPK2_Hsap_MK2 GEAIQYLHSI-----------------------------------------NIAHRDVKP MAPk-Ak2_Dmel_MK2 CAAVDYLHSR-----------------------------------------DIAHRDLKP Lk6_Dmel_MNK ASGLDFLHKK-----------------------------------------GIAHRDLKP MNK2_Mmus_MNK ASALDFLHNK-----------------------------------------GIAHRDLKP MNK1_Mmus_MNK ATALDFLHTK-----------------------------------------GIAHRDLKP MAPKAPK5_Mmus_MK5 ALALQHCHLL-----------------------------------------NIAHRDLKP MAPKAPK3_Mmus_MK2 GTAIQFLHSR-----------------------------------------NIAHRDVKP MAPKAPK2_Mmus_MK2 GEAIQYLHSI-----------------------------------------NIAHRDVKP R166.5_Cele_MNK SLALKFMHDR-----------------------------------------GIAHRDVKP K08F8.1_Cele_MK2 GNAVMYLHDM-----------------------------------------NIAHRDIKL C44C8.6_Cele_MK2 CSAVAHLHRM-----------------------------------------SIAHRDLKP MAPKAPK2_Spur_MK2 GQAVHHLHVM-----------------------------------------NIAHRDLKP MAPKAPK5a_Spur_MK2 ASAVLQCHSL-----------------------------------------NIAHRDLKP MAPKAPK5b_Spur_MK5 ------------------------------------------------------------ Mnk_Spur_MNK ASALSFLHNK-----------------------------------------GIAHRDLKP AqueK073_Aque_MK2 SLAVAHLHHM-----------------------------------------DIAHRDLKP AqueK074_Aque_MK5 VRGVQFCHRL-----------------------------------------NIAHRDIKP AqueK075_Aque_MNK AAALSFLHRQ-----------------------------------------GIAHRDLKP MNK2_Hsap_MNK ENILCEHP---NQVSPVKICDFDLGSGIKLNGD----CSPISTPELLTPCGSAEYMAPEV MNK1_Hsap_MNK ENILCESP---EKVSPVKICDFDLGSGMKLNNS----CTPITTPELTTPCGSAEYMAPEV MAPKAPK5_Hsap_MK5 ENLLFKDN---SLDAPVKLCDFGFAKI--D------------QGDLMTPQFTPYYVAPQV MAPKAPK3_Hsap_MK2 ENLLYTSK---EKDAVLKLTDFGFAKETT-------------QNALQTPCYTPYYVAPEV MAPKAPK2_Hsap_MK2 ENLLYTSK---RPNAILKLTDFGFAKETTS------------HNSLTTPCYTPYYVAPEV MAPk-Ak2_Dmel_MK2 ENLLYTTT---QPNATLKLTDFGFAKETFT------------SYTLQTPCYTPYYVAPEV Lk6_Dmel_MNK ENILCVKT---DSLCPIKICDFDLGSGIKFTTDI---SSPAATPQLLTPVGSAEFMAPEV MNK2_Mmus_MNK ENILCEHP---NQVSPVKICDFDLGSGIKLNGD----CSPISTPELLTPCGSAEYMAPEV MNK1_Mmus_MNK ENILCESP---EKVSPVKICDFDLGSGVKLNNS----CTPITTPELTTPCGSAEYMAPEV MAPKAPK5_Mmus_MK5 ENLLFKDN---SLDAPVKLCDFGFAKV--D------------QGDLMTPQFTPYYVAPQV MAPKAPK3_Mmus_MK2 ENLLYTSK---EKDAVLKLTDFGFAKETT-------------QNALQTPCYTPYYVAPEV MAPKAPK2_Mmus_MK2 ENLLYTSK---RPNAILKLTDFGFAKETTS------------HNSLTTPCYTPYYVAPEV R166.5_Cele_MNK ENVLCTDP---NHVSPVKLCDLDLASQRPPQHERHPLSQVASEPDLASPVGSAEFMAPEV K08F8.1_Cele_MK2 ENILCSGT---GDNCVYKLGDYGFAKRPER------------NVLMESPCCTPFYAPPEV C44C8.6_Cele_MK2 ENLLYVTT---ASNAALKLTDFGFAKKTDESE----------PQGLKTACFTPYYCAPEV MAPKAPK2_Spur_MK2 ENLLYRDR---TPNSLLKLTDFGFAKETT-------------TTNLQTPCYTPYYVAPEV MAPKAPK5a_Spur_MK2 ENLLLKDN---SEDSPVKLSDFGFAKV--D------------DGTLMTPHFTPYYVA--- MAPKAPK5b_Spur_MK5 ------------------------------------------------------------ Mnk_Spur_MNK ENILCESM---YSISPIKICDFGLGSGIHLSSQY---NTPVTTPELLTPVGSAEFMAPEI AqueK073_Aque_MK2 ENLLYSDK---TPSAKLKLTDFGFAKENHG------------SKALTTPCYTPYYVAPEV AqueK074_Aque_MK5 ENLLLLKPASNPEDVVIKLSDFGFAKV--D------------NGDLKTPQFTPYYVAPQV AqueK075_Aque_MNK ENILCQTK---DEVVPIKVCDFDLSSMMSQH-------TPATTPNLFTPVGSAEYMAPEV MNK2_Hsap_MNK VEAFS-------------EEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGS-DCGWDR MNK1_Hsap_MNK VEVFT-------------DQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGA-DCGWDR MAPKAPK5_Hsap_MK5 LEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHS------- MAPKAPK3_Hsap_MK2 LGP------------------EKYDKSCDMWSLGVIMYILLCGFPPFYSNTG-------- MAPKAPK2_Hsap_MK2 LGP------------------EKYDKSCDMWSLGVIMYILLCGYPPFYSNHG-------- MAPk-Ak2_Dmel_MK2 LGP------------------EKYDKSCDIWSLGVVMYIIMCGFPPFYSNHG-------- Lk6_Dmel_MNK VDLFV-------------GEAHYYDKRCDLWSLGVIAYILLCGYPPFSGNCGE-DCGWNR MNK2_Mmus_MNK VEAFS-------------EEASIYDKRCDLWSLGVILYILLSGYPPFVGHCGS-DCGWDR MNK1_Mmus_MNK VEVFR-------------DEATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGA-DCGWDR MAPKAPK5_Mmus_MK5 LEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHS------- MAPKAPK3_Mmus_MK2 LGP------------------EKYDKSCDMWSLGVIMYILLCGFPPFYSNTG-------- MAPKAPK2_Mmus_MK2 LGP------------------EKYDKSCDMWSLGVIMYILLCGYPPFYSNHG-------- R166.5_Cele_MNK VDAYV-------------GDSLKYDKKCDTWSLGVILYIMLAGYAPFQGMCDDEDCGWSE K08F8.1_Cele_MK2 LGR------------------ERYDKSCDMWSLGVAMYILLCGYPPFYSMKG-------- C44C8.6_Cele_MK2 LGT------------------EKYDKSCDLWSIGVIMYILLCGYPPFYSQHG-------- MAPKAPK2_Spur_MK2 LGP------------------EKYDKSCDMWSLGVIMYILLCGFPPFYSNHG-------- MAPKAPK5a_Spur_MK2 ------------------------------------------------------------ MAPKAPK5b_Spur_MK5 ----------------------TYDKGCDMWSLGVIIYIMLCGYPPFYPDTPS------- Mnk_Spur_MNK VEAFIYD-----------LQATVYDKRCDLWSLGVILYILLCGHPPFVGSCGE-DCGWDR AqueK073_Aque_MK2 LGP------------------EKYDTSCDMWSIGVITYILLCGFPPFYSYGG-------- AqueK074_Aque_MK5 LEAQKRQKESLSG--YKHRTPYYYDKSCDIWSIGVIMYIMLCGYPPFYSEVPH------- AqueK075_Aque_MNK LDTFT-------------GEIFSYDKKCDLWSLGVLVYMMLSGSPPFTGGCRT-DCGWEK MNK2_Hsap_MNK GEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPW MNK1_Hsap_MNK GEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPW MAPKAPK5_Hsap_MK5 ----RTIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPW MAPKAPK3_Hsap_MK2 ----QAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPW MAPKAPK2_Hsap_MK2 ----LAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPW MAPk-Ak2_Dmel_MK2 ----LAISPGMKNRIRTGQYDFPDPEWTNVSQAAKDLIKGMLNVDPSKRLRIQDVISNKW Lk6_Dmel_MNK GENCRTCQELLFESIQEGHFSFPEAEWHDVSDEAKDLISNLLVKKASNRLSAEAVLNHPW MNK2_Mmus_MNK GEACPACQNMLFESIQEGKYEFPDKDWSHISFAAKDLISKLLVRDAKQRLSAAQVLQHPW MNK1_Mmus_MNK GEVCRMCQNKLFESIQEGKYEFPDKDWAHISNEAKDLISKLLVRDAKQRLSAAQVLQHPW MAPKAPK5_Mmus_MK5 ----RTIPKDMRKKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPW MAPKAPK3_Mmus_MK2 ----QAISPGMKRRIRLGQYSFPNPEWLDVSEDAKQLIRLLLKTDPTERLTIMQFMNHPW MAPKAPK2_Mmus_MK2 ----LAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPW R166.5_Cele_MNK GKPCEDCQQDLFHRIQDGYYEFPEEEWGMISEEAKDLVSNLLKRDPVDRLVTVSFV-NPF K08F8.1_Cele_MK2 ----VALSPGMRSRIANAYYAFPHEEWDCVSKDTKDDIRCLLRTNPSDRLTIHELMATPL C44C8.6_Cele_MK2 ----QPMSPGMKAKIKSGQYTFPSPEWDCVSEAAKDLIRKLLRTEPTERITIEQTMEHKW MAPKAPK2_Spur_MK2 ----MAISPGMKRRIRNGQYEFPDPEWSQVSEDAKNLIKKLLRTDPAERLSIQEFMNSPW MAPKAPK5a_Spur_MK2 ------------------------------------------------------------ MAPKAPK5b_Spur_MK5 ----RQLSKDMRHKIMAGQYEFPTEEWSLISDEAKDVVKRLLRVDPTERLTIEELCSHPW Mnk_Spur_MNK GEACQDCEELLLHCIQSGEYDFHGAEWEHISAGAKDLISHLLVRDAKQRYTAGMVLNHPW AqueK073_Aque_MK2 ----APISPGMKKRIRQGQYGFPDPEWTNVSSQAKDLIKGLLKTNPADRFTIDDVLRHRW AqueK074_Aque_MK5 ----QALSNRMKQKIMSADFDFPENDWKAVTDEAKDLIRKMLCVEPSERLSIEEVLHHPW AqueK075_Aque_MNK GEECEKCQAILLEKIGKGQYSFPQEIWASISSEAKDLISSLLQRDVRKRLSADEVLAHPW MNK2_Hsap_MNK V MNK1_Hsap_MNK V MAPKAPK5_Hsap_MK5 L MAPKAPK3_Hsap_MK2 I MAPKAPK2_Hsap_MK2 I MAPk-Ak2_Dmel_MK2 I Lk6_Dmel_MNK I MNK2_Mmus_MNK V MNK1_Mmus_MNK V MAPKAPK5_Mmus_MK5 L MAPKAPK3_Mmus_MK2 I MAPKAPK2_Mmus_MK2 I R166.5_Cele_MNK A K08F8.1_Cele_MK2 V C44C8.6_Cele_MK2 I MAPKAPK2_Spur_MK2 V MAPKAPK5a_Spur_MK2 P MAPKAPK5b_Spur_MK5 L Mnk_Spur_MNK V AqueK073_Aque_MK2 I AqueK074_Aque_MK5 L AqueK075_Aque_MNK I