CLUSTAL W (1.83) multiple sequence alignment PDK1_Hsap FKFGKILGEGSFSTVVLARELAT----SREYAIKILEKRHIIKENKVPYVTRERDVMSRL Pk61C_Dmel FIFGRYIGEGSYSIVYLAVDIHS----RREYAIKVCEKRLILRERKQDYIKREREVMHQM PDK1_Mmus FKFGKILGEGSFSTVVLARELAT----SREYAIKILEKRHIIKENKVPYVTRERDVMSRL pdk-1_Cele ILKNIPLA----KTVFRCREVAT----DAMFAVKVLQKSYLNRHQKMDAIIREKNILTYL PKH2_Scer FKFGSVIGDGAYSTVMLATSIDT----KKRYAAKVLNKEYLIRQKKVKYVSIEKTALQKL PKH1_Scer FKFGEQLGDGSYSSVVLATARDS----GKKYAVKVLSKEYLIRQKKVKYVTVEKLALQKL W04B5.5_Cele YSVEKEVGEGSFSTVYLARRKEPKNDENPEVALKICLKRLILKNKMVPYIHREKEALALI YDR466W_Scer FIFKEELGHGSYSTVFKALDKKS---PNKIYAIKVCSKKHIIKEAKVKYVTIEKNTMNLL Pdk1A_Ddis FIIGKVLGEGSYGAVVLGTEKET----QQQYAIKILEKKQIIKENKIKYVQIEKEIFCKS Pdk1B_Ddis FDFIRTIGKGAYGKVKLVIEKET----QLIFASKILNKKLIIKEKKAKYVNTEKTILDSL 8643_Tthe FSNNKNLGRGSFGEVILAKNKSN----NEFCAIKILEKSYLAREKKQYQVFIEKEVLTHI PDK1_Spur FRFGTILGEGSYSEVVLATEIAT----GNQYAIKVLEKRHIIREKKEKYVLREKEVLSRL CC1G_15192_Ccin FDVGEEIAWGSLATIVEGVHKKS----GKLFAIKMLNKMQLSKKKMVRSAMLEKDALIAL AqueK012_Aque FNFDRIIGEGSYSTVSS------------CALVKILDKRHIIKEKKVQYVSREKDVLARI PDK1-2_Smoe FAYGRLLGMGSYSKVVRAKKKDS----GAEFALKIMDKKHITKENKVAYVKMERLILDHL PDK1-1_Smoe -------------QVVRAKKKDS----GAEFALKIMDKKHITKENKVAYVKMERLILDHL GK002_Glam FDVIDFLGEGSYGKVYRAIDAET----GLEVGLKVINRKALENDKLLYTLDREVVALRTA : *: : : .. * : PDK1_Hsap D-----HPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKI--GSFDETCTRFYTAEIV Pk61C_Dmel T----NVPGFVNLSCTFQDQRSLYFVMTYARKGDMLPYINRV--GSFDVACTRHYAAELL PDK1_Mmus D-----HPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKI--GSFDETCTRFYTAEIV pdk-1_Cele SQECGGHPFVTQLYTHFHDQARIYFVIGLVENGDLGESLCHF--GSFDMLTSKFFASEIL PKH2_Scer N----NSPSVVRLFSTFQDESSLYFLLEYAPNGDFLSLMKKY--GSLDETCARYYAAQII PKH1_Scer N----GTKGIFKLFFTFQDEASLYFLLEYAPHGDFLGLIKKY--GSLNETCARYYASQII W04B5.5_Cele SREENAHPGIVTLYATFQDSESLYFVLEYAKYGDLCTLMQKQPDSKFNVADSRYYAANLL YDR466W_Scer AQ--KHHAGIIKLYYTFHDEENLYFVLDFAPGGELLSLLHKM--GTFNDIWTRHFTAQLI Pdk1A_Ddis N-----HPNIVKLFFTFRSEQCLYYVLELCSQGDLLHQIKKV--GSFDYRSCQYYVAEII Pdk1B_Ddis D-----NPNIVKLFYTFQDENNLYFILEYCPNGDLLGALKKA--GCFSIDVVRFYAAEIL 8643_Tthe R-----FDGIIQLLGSFKDNQFLYFVLEYCEGGEFSSYLQHNF-KFLNQDTIKFYAAEIV PDK1_Spur D-----HPFFVRLYFTFQDNYKLYFGLSLAKRGELLPYIKKL--GSFDESSSRFYTSEII CC1G_15192_Ccin SS--HPHPGIVRLHYCFQDAANLYFVLDLAPNGDLKSLTLKT--GSLSLECARYYTAQMI AqueK012_Aque D-----HPFFVKLYFTFQDKDNLYFGLSFAEQGELLDYLRKV--GAFDENATRFYTSEIV PDK1-2_Smoe D-----HPGVVRLFFTFQDTHNLYMGLECCHGGELFDQIRRK--GRLSLEEARFYAAEIV PDK1-1_Smoe D-----HPGVVRLFFTFQDTHNLYMGLECCHGGELFDQIRRK--GRLSLEEARFYAAEIV GK002_Glam QN--KNLTNIIRLYSKTDKNDFTTLILEYASLGDLSSLIKCY--RVLPEDWTRFLIAEII . * . : *:: : :. :::: PDK1_Hsap SALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESK--------------- Pk61C_Dmel LACEHMHRRNVVHRDLKPENILLDEDMHTLIADFGSAKVMTAHN---------------- PDK1_Mmus SALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESK--------------- pdk-1_Cele TGLQFLHDNKIVHRDMKPDNVLIQKDGHILITDFGSAqafE------------------- PKH2_Scer DAIDYLHSNGIIHRDIKPENILLDGEMKIKLTDFGTAKLLNPTNNSV------------- PKH1_Scer DAVDSLHNIGIIHRDIKPENILLDKNMKVKLTDFGTAKILPEEPSNTAD----------- W04B5.5_Cele SALEHIHKLGIIHRDVKADNLLVKSDGRIMLTDFGSSKFLSDYQKIQEN----------- YDR466W_Scer DALEFIHSHGIIHRDLKPENVLLDRDGRLMITDFGAAATIDPSLSGDSAKF--------- Pdk1A_Ddis SGLEHLHSLGIVHRDLKPENILMSSDLHVKITDFGTGKILPPPQSSQQQQQQQQQQQQLP Pdk1B_Ddis IALEYLHGKGIAHRDLKPENILLGKNQHLKLSDFGSAKQLSIGSH--------------- 8643_Tthe YILENLHKNGIIHRDLKPENLMLTKDNHLKIIDFGTCGFDRRIPEDLFQKI--------- PDK1_Spur LALEYLHSMGIIHRDLKPENILLNEKMHIQITDFGTAKIIGADDKK-------------- CC1G_15192_Ccin DAINLMHEAGVAHRDIKPENCLLDKSMRIKIADFGSAYVTSTPL---------------- AqueK012_Aque IALEYLHGKGIIHRDLKPENILLNKDMHIQITDFGTAKIFESDE---------------- PDK1-2_Smoe DVLEYIHGQGLIHRDLKPENLLLTADGHIKVADFGSAKVTTPLQNG-------------- PDK1-1_Smoe DVLEYIHGQGLIHRDLKPENLLLTADGHIKVADFGSAKVKYLSFSCSFLVS--------- GK002_Glam LGLEGLHSIGYCHRDIKPSNILLTRGGHVRIADFGTSKQLPLDEVSMAIGTK-------- : :* ***:*..* :: : : ***: PDK1_Hsap ------------------------------------------------------------ Pk61C_Dmel ------------------------------------------------------------ PDK1_Mmus ------------------------------------------------------------ pdk-1_Cele ------------------------------------------------------------ PKH2_Scer ------------------------------------------------------------ PKH1_Scer ------------------------------------------------------------ W04B5.5_Cele ------------------------------------------------------------ YDR466W_Scer --------------------N--------------------------------------- Pdk1A_Ddis TNSSGNLSSLLNNVNNLSVST---------------------DLTQQQQNRTSSVDSAST Pdk1B_Ddis ------------------------------------------------------------ 8643_Tthe --------------NNIKKKF---------------------PQ---------------E PDK1_Spur ------------------------------------------------------------ CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ------------------------------------------------------------ PDK1-2_Smoe ------------------------------------------------------------ PDK1-1_Smoe --------------------F--------------------------------------- GK002_Glam -------------------SFPPSAYMSTSSAAASNDSQGTLQ----------------- PDK1_Hsap ------------------------------------------------------------ Pk61C_Dmel ------------------------------------------------------------ PDK1_Mmus ------------------------------------------------------------ pdk-1_Cele ------------------------------------------------------------ PKH2_Scer ----------------------------------------------------------SK PKH1_Scer ----------------------------------------------------------GK W04B5.5_Cele ----------------------------------------------------------PV YDR466W_Scer ----------------------------------------------------------SD Pdk1A_Ddis TDSMISPNLQPTTTTTNNNNNNNNNNNNNNNNTAAGSNTNTNTNTNINTNINANINNIKT Pdk1B_Ddis ------------------------------------------------------------ 8643_Tthe TD--------------------------------------------------------PM PDK1_Spur ------------------------------------------------------------ CC1G_15192_Ccin ------------------------------------------------------------ AqueK012_Aque ------------------------------------------------------------ PDK1-2_Smoe -----------------------------------------------------------L PDK1-1_Smoe ----------------------------------------------------------SV GK002_Glam -K--------------------------------------------------------KL PDK1_Hsap ------QARANSFVGTAQYVSPELLTEKSAC-KSSDLWALGCIIYQLVAGLPPFRAG--- Pk61C_Dmel ------RHRKASFVGTAQYVSPEVLQNGPIT-PAADLWALGCIVYQMIAGLPPFRGS--- PDK1_Mmus ------QARANSFVGTAQYVSPELLTEKSAC-KSSDLWALGCIIYQLVAGLPPFRAG--- pdk-1_Cele ----ENTARRTTFVGTALYVSPEMLADGDVG-PQTDIWGLGCILFQCLAGQPPFRAV--- PKH2_Scer -PEYDLSTRSKSFVGTAEYVSPELLNDSFTD-YRCDIWAFGCILFQMIAGKPPFKAT--- PKH1_Scer -PYFDLYAKSKSFVGTAEYVSPELLNDNYTD-SRCDIWAFGCILYQMLAGKPPFKAA--- W04B5.5_Cele -EEEQPTGRRSSFVGTAFFVTPELLTGSEMS-PSSDLWAFSVTLYLFLTGIYPFNDM--- YDR466W_Scer SNGSKDNQNCASFVGTAEYVSPELLLYNQCG-YGSDIWALGCMIYQFVQGQPPFRGE--- Pdk1A_Ddis -TEIPKLTRNNSFVGTAEYVSPELISNKETS-TDSDLWALGCIIYQMASGRVPFRGK--- Pdk1B_Ddis ----HKGSRSGSFCGTAEYVCPELLTEKSAG-VEADIWSYGCLLYQLVSGKLPFKGF--- 8643_Tthe -DDEDSRTRSSTFVGTAEYVSPELLEGEICT-SSADLWALGCIIYRMFVGNTPFVDVND- PDK1_Spur ----EGQPRAKSFVGTAQYVSPELLTEKSAT-KSSDLWALGCIVYQLQAGLPPFRAS--- CC1G_15192_Ccin -----STPKTNTFVGTAAFLSPEVLLRQEANPRGPDLWAVGACLFFYLFGTYPFSAM--- AqueK012_Aque ------DEKASSFVGTAEYVSPELLQSKVAY-KSSDLWALGCIIYQFLAGRPPFHAAYVN PDK1-2_Smoe -SDAQADDKSCTFVGTAEYVSPEVLNGHPVT-IGADLWALGCIIYQMLEGRPPFKGG--- PDK1-1_Smoe -HFRFTDDKSCTFVGTAEYVSPEVLNGHPVT-IGADLWALGCIIYQMLEGRPPFKGG--- GK002_Glam -QNM-DQQPRCSIYGTVCYNAPESNRHGLLYMSPQDVWGLGCILYECLTGMPAFMGD--- :: **. : ** *:*. . :: * .* PDK1_Hsap ------------NEYLIFQKIIKLEYDFP---------EKFF-PKARDLVEKLLVLDATK Pk61C_Dmel ------------NDYVIFKEILDCAVDFP---------QGFD-KDAEDLVRKLLRVDPRD PDK1_Mmus ------------NEYLIFQKIIKLEYHFP---------EKFF-PKARDLVEKLLVLDATK pdk-1_Cele ------------NQYHLLKRIQELDFSFP---------EGFP-EEASEIIAKILVRDPST PKH2_Scer ------------NEYLTFQKVMKVQYAFT---------PGFP-LIIRDLVKKILVKNLDR PKH1_Scer ------------NEYLTFQKVMKIQYAFT---------AGFP-QIVKDLVKKLLVRDPND W04B5.5_Cele ------------SEYLVFRRIQDILYTFS---------EDFPDENAKNLIERLLVKEQKS YDR466W_Scer ------------NELKTFEKIVALDYPWGPNNRINNSTSPIN-PLVINLVQKILVIEVNE Pdk1A_Ddis ------------TEFLTFQKVSNRELVYP---------INMN-PVIKDLVEKLLVIKPTD Pdk1B_Ddis ------------NEYQTFLLITKREFSYP---------DNFD-KCCMNLIDQLLDLDPYK 8643_Tthe ---------ATNNEFKVFNKVKACQYYIP---------DSVP-PEAADLIKNLLKRNPFE PDK1_Spur ------------NEYMIFQKIIKLEYDFP---------DGFS-QTARDLVSKLLVIDPSK CC1G_15192_Ccin ------------TDYLIMERIKKLDYKIP---------EGCD-PDAADLIKRLLVHHPQE AqueK012_Aque YTCSPPLFIMCRNEYLCFQKIIKHEYSIP---------DGFP-DNAKDLVENLLVSDPTK PDK1-2_Smoe ------------SEYLTFQKVLAKDLVIP---------SHFP-SAAKELINKLLNLEPDK PDK1-1_Smoe ------------SEYLTFQKVLAKDLVIP---------SHFP-SAAKELINKLLNLEPDK GK002_Glam ------------VELAIMQAIEKQKVIVP---------KTVS-PDAADLIKRLLTKDPTK : : : ::: .:* . PDK1_Hsap RLGCEE--MEGYGPLKAHPFF Pk61C_Dmel RLGAQDE-FGYYESIRAHPFF PDK1_Mmus RLGCEE--MEGYGPLKAHPFF pdk-1_Cele RITS--------QELMAHKFF PKH2_Scer RLTI--------SQIKEHHFF PKH1_Scer RLTI--------KQIKAHLFF W04B5.5_Cele RLTS--------QEIKEHKFF YDR466W_Scer RISL--------EQIKRHPYF Pdk1A_Ddis RLGSSST-PGGFDNLKAHPFF Pdk1B_Ddis RPTI--------SEIKNHEFF 8643_Tthe RIGGGEPGVNDINTLKKHPFF PDK1_Spur RLGCDE--CGGYPALKAHPFL CC1G_15192_Ccin RLGVPP--NSSIDELRQHPFF AqueK012_Aque RLGCDK--MGGYPPLKAHYFF PDK1-2_Smoe RPGAGP---AGYTALKSHAFF PDK1-1_Smoe RPGAGP---AGYAALKSHAFF GK002_Glam RFNG------GWRAIKKHPFF * : * ::