CLUSTAL W (1.83) multiple sequence alignment lok_Dmel YYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMK CHK2_Mmus YIMSKTLGSGACGEVKMAFERKTCQKVAIKIISKRRFALG-SSREADTAPSVETEIEILK chk-2_Cele HVTSHSLGKGGFGKVLLGYKKSDRSVVAIKQLNTQFS-TR-CSRAIAKTRDIRNEVEVMK RAD53_Scer SIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIG--------NMDGVTRELEVLQ DUN1_Scer YLLGKELGAGHYALVKEAKNKKTGQQVAVKIFHAQQND-D-Q----KKNKQFREETNILM CHK2_Hsap YIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIG-SAREADPALNVETEIEILK T08D2.7_Cele HVTSHLLGKGGFGKVLLGYKKSDRSVVAIKQLNTQFS-TR-CSRAIAKTRDIQNEVEVMK FHAK1_Ddis YDFIKELGSGNFSVVYEGVNKNTGKRVAIKHLNLSKINTH-TP---KFKSQLNREIEILK FHAK2_Ddis YYFVKEIGSGGYGIVYEGLYKLNGKRVAIKHIDLLKNGS--TS---KSMELVSKEYNALK FHAK3_Ddis YSIQGILGTGNFSVVKRCIRRDTGEVFAVKIIDKKKFWSQ-T----KTRRQMESEVEILQ FHAK4_Ddis YDLREVLGTGNFASVRLGVEKETGNKYAIKIIDKKKMSMT--S---KRKDSLMDEVNVLT FHAK5_Ddis ----EMLGQGNFATVKLAVERTTGVKYAVKIVDKKKYFMN-SS---ARKDSLMDEVNILR Chk2_Spur FIMSKVLGRGACGQVKLAFEKGTCRKVAVKIIEKKTFSIG-GTMVRNMEKTVMEEVRILK CC1G_09319_Ccin YDVSTELGKGSFATVMKAVNRKTGVWYAVKMIKDKRAAHA-GD---IRNSAIAREISIME AqueK082_Aque YTMSKQIGKGACGIVKLAFHRETCKGYAIKIISKKMFSVG-P----HLGRAAMEEVKIIK AqueK083_Aque YTMSKQIGKGACGIVKLAFHRETCKGYAVKIISKKMFSVG-P----HLGRAAMEEVKIIK :* * . * *:* . * : lok_Dmel NLSHPCVVRMHDIVDK-----PDSVYMVLEFMRGGDLLNRIISNK----LLSEDISKLYF CHK2_Mmus KLNHPCIIKIKDVFDA-----E-DYYIVLELMEGGELFDRVVGNK----RLKEATCKLYF chk-2_Cele KLSHPNIVAIYDWITV-----AKYSYMVIEYVGGGEFFSKVVDSKYNRMGLGESLGKYFA RAD53_Scer KLNHPRIVRLKGFYED-----TESYYMVMEFVSGGDLMDFVAAHG----AVGEDAGREIS DUN1_Scer RVQHPNIVNLLDSFVEPISKSQIQKYLVLEKIDDGELFERIVRKT----CLRQDESKALF CHK2_Hsap KLNHPCIIKIKNFFDA-----E-DYYIVLELMEGGELFDKVVGNK----RLKEATCKLYF T08D2.7_Cele KLSHPNIVAIYDCITV-----AKYSYMVIEYVGGGEFFSKLVDSKYNQMGLGESLGKYFA FHAK1_Ddis FINHENVVEIYDIFYT----KDQQLFFILELANGGELYNKIGFNE---PLLNENQSKFIF FHAK2_Ddis NIKHRNVIEFFDIVFS----S-TDCFFIVELATN-DL-SNLLRK----RCVDEDDIKRIC FHAK3_Ddis KIKHPNIISIIDIVQS-----DRYFYIVLELATGGELFEKIKQKG----RFSEPEAKDTF FHAK4_Ddis KVKHQNIISIKEVFET-----QKNLYLVLELVTGGELFDKIVSER----KFQEDTCRYIL FHAK5_Ddis GLSHPNIIQIIEVFEN-----EKVLSLILELVECGELLNDIVSNL----FYTEDKAKTLF Chk2_Spur RLHHPCIIGIEDVCDT-----PEVLYIVLELVESGELFDRVVSLG----KFDEATAKFYF CC1G_09319_Ccin KLKHRNICELKEVFME---EGSSDINLVLELVEGGDLLEYILNRG----GLSEVDAKHIT AqueK082_Aque ALQHPCIIRVEDLYES-----TDSLYIVLELVEGGELFDRVILNG----KFNDKVGKLLF AqueK083_Aque ALQHPCIIRVEDLYES-----TDSLYIVLELVEGGELFDRVILNG----KFNDKVGKLLF : * : . :::* :: . : : : lok_Dmel YQMCHAVKYLHDRGITHRDLKPDNVLLETN----------------DEE-TLLKVSDFGL CHK2_Mmus YQMLVAVQYLHENGIIHRDLKPENVLLSSQ----------------EED-CLIKITDFGQ chk-2_Cele FQLIDAILYLHSVGICHRDIKPENILCSDK----------------AER-CILKLTDFGM RAD53_Scer RQILTAIKYIHSMGISHRDLKPDNILIEQ-----------------DDP-VLVKITDFGL DUN1_Scer KQLLTGLKYLHEQNIIHRDIKPENILLNITRRENPSQVQLGPWDEDEID-IQVKIADFGL CHK2_Hsap YQMLLAVQYLHENGIIHRDLKPENVLLSSQ----------------EED-CLIKITDFGH T08D2.7_Cele FQLIDAVLYLHSVGICHRDIKPENILCSNK----------------AER-CILKLTDFGM FHAK1_Ddis KQILNAVSYLHSKGIAHRDLKPENILFDSY----------------GDDYLKIKITDFGL FHAK2_Ddis KQLLLGFNYLHNLGIVHRDLKPENILYNEF----------------KQG-FSIKITDFGL FHAK3_Ddis KQILEAVSYLHDLNISHRDLKPENILISAVS--------------HGKS-SVIKVTDFGL FHAK4_Ddis KQLCDSVRYLHSNGIAHRDLKPENILLATP-----------------NS-FLLKISDFGL FHAK5_Ddis RQIVDGVLYLHNKGIAHRDLKPENILLKHKN--------------FNQN-DAIKLTDFGL Chk2_Spur YQMITACKYLHDNGITHRDLKPENLLLMSD----------------DKE-TILKVTDFGL CC1G_09319_Ccin HQICSALSYIHQQGIAHRDLKPENVLLTKS-----------------NP-PVVKVADFGL AqueK082_Aque YQMVVAVKYLHDKGITHRDLKPENILLSST----------------DEE-TLIKVTDFGL AqueK083_Aque YQMVVAVKYLHDKGITHRDLKPENILLSST----------------DEE-TLIKVTDFGL *: . *:*. .* ***:**:*:* :*::*** lok_Dmel SKFVQKDSVMRTLCGTPLYVAPEVLITG---------------------GREAYTKKVDI CHK2_Mmus SKILGETSLMRTLCGTPTYLAPEVLVSN---------------------GTAGYSRAVDC chk-2_Cele AKN--SVNRMKTRCGTPSYNAPEIVANE---------------------GV-EYTPKVDI RAD53_Scer AKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSV--S---------PDEYEERNEYSSLVDM DUN1_Scer AKFTGEMQFTNTLCGTPSYVAPEVLTK------------------------KGYTSKVDL CHK2_Hsap SKILGETSLMRTLCGTPTYLAPEVLVSV---------------------GTAGYNRAVDC T08D2.7_Cele AKN--SVNRMKTHCGTPSYCAPEIVANQ---------------------GV-EYTPKVDI FHAK1_Ddis ARFIHEGELAKTLCGSPLYVAPEVILSLHHKNKYGTNSSSSSQSPTKDINSVGYGKSCDA FHAK2_Ddis SSFVEESQYLQTFCGTPLFFAPEVIANNF--------------------FSNGYGKSCDL FHAK3_Ddis AKIIGEKEMATTLCGTPLYVAPEIIRNCLHGD--G-----------GAQVNTGYGKEVDV FHAK4_Ddis SRAMDEGTYMKTMCGTPQYVAPEILTKG---------------------EREGYGKSVDL FHAK5_Ddis SRTVSDGSFMKTMCGTPQYLAPEILTSSG--------------------GHNGYGLEVDC Chk2_Spur SKFVGEQSLMKTLCGTPTYLAPEILTSM---------------------GMGGYTKAVDC CC1G_09319_Ccin AKIVDSLTMLRTMCGTPSYLAPEVVKQV---------------------NQEGYDNLVDS AqueK082_Aque SKFVGEQSLMKTLCGTPSYLAPEVLWSA---------------------GLGGYSKAVDC AqueK083_Aque SKFVGEQSLMKTLCGTPSYLAPEVIKSA---------------------GLGGYSKAVDC : . * **: : ***:: * * lok_Dmel WSLGVVLFTCLSGTLPFSDEY----GT-PAAQQIKKGRFAYGHPSWKSVSQRAKLLINQM CHK2_Mmus WSLGVILFICLSGYPPFSEHK----TQVSLKDQITSGKYNFIPEVWTDVSEEALDLVKKL chk-2_Cele WSLGCVLFITFSGYPPFSEEY----TDMTMDEQVLTGRLIFH-AQWRRITVETQNMIKWM RAD53_Scer WSMGCLVYVILTGHLPFSGS-----TQDQLYKQIGRGSYHEGPLKDFRISEEARDFIDSL DUN1_Scer WSAGVILYVCLCGFPPFSDQL----GPPSLKEQILQAKYAFYSPYWDKIDDSVLHLISNL CHK2_Hsap WSLGVILFICLSGYPPFSEHR----TQVSLKDQITSGKYNFIPEVWAEVSEKALDLVKKL T08D2.7_Cele WSLGCVLFITFSGYPPFSEEY----TDLKMDEQVLTGRLFFH-EQWHRITDETQNMIQWM FHAK1_Ddis WSLGAILYIVLCGTPPFDDDDDEEMSTPQLFEKIVSGNYRVEKLEKSLISSSAADLVKGL FHAK2_Ddis WSIGVTLYLSLCKYKPFIVDC----R--DLYHSFINGNLGFTSKKWAKISNYAKDLVRRL FHAK3_Ddis WSLGCILYILLSGRPPFDFDH----TNNFNLKLINQGLYNFSLPVWDVVTENAKDLIKKL FHAK4_Ddis WSIGVITYILLCGFPPFGDPQ----T-KDFFEKIKNGGFSFPSPYWDEISDEAKSLIKNL FHAK5_Ddis WSMGAILYIMLCGYPPFDDSR----E-VSIFEQIRNAKFEFDPEDWSSVSEEAKDLIKRL Chk2_Spur WSIGVILYICLAGYPPFSDEI----KAMNLDEQIKRGYYSFPT----------------- CC1G_09319_Ccin WSVGVIVFSMLTNASPFIEDE----TQRDIRTRIAERRIDWSVLEAQNPSAECIHFIRSL AqueK082_Aque WSLGVILYIMLGGYPPFSDEI----REHSLHDQICQGIYSFPPAYWNGVSKD-------- AqueK083_Aque WSLGVILYIMLGGYPPFSDEI----REHSLHDQICQGIYSFPPAYWNGVSKDGIDLIEKL ** * : : ** . lok_Dmel LIVDPERRPSIDDVLQSSWL CHK2_Mmus LVVDPKARLTTEEALNHPWL chk-2_Cele LTVEPSNRPSAVELMSTQWM RAD53_Scer LQVDPNNRSTAAKALNHPWI DUN1_Scer LVLNPDERYNIDEALNHPWF CHK2_Hsap LVVDPKARFTTEEALRHPWL T08D2.7_Cele LTVEPLIRPSAVELMSTQWM FHAK1_Ddis LTVDPDKRLTVEQALNHPWI FHAK2_Ddis LVIDPEHRITIKEALNHPWF FHAK3_Ddis LNVDPTKRISTKGALSHD-W FHAK4_Ddis IKVDVEKRFTIDQALNHP-W FHAK5_Ddis LCVDPHKRYTCNNIIQHP-W Chk2_Spur -------------------K CC1G_09319_Ccin LQEDPSVRMSLTQALDHPWL AqueK082_Aque --VDSSKRWTTAQALEHTWL AqueK083_Aque LTVDSSKRWTSAQALEHTWL