CLUSTAL W (1.83) multiple sequence alignment SgK288_Hsap ---WRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPP---DAASSDVNYLIEEAAK-MKK RIPK3_Hsap LENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSK-------------AISREVKA-MAS RIPK2_Hsap LADLRYLSRGASGTVSSARHADWRVQVAVKHLHI-HT---PLLDSERKDVLREAEI-LHK RIPK1_Hsap FLESAELDSGGFGKVSLCFHRTQG-LMIMKTVYKGPNC-----IEHNEALLEEA-KMMNR ANKRD3_Mmus FAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLH-----VDDRERMELLEEAKK-MEM ANKRD3_Hsap FTGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLH-----VDDRERMELLEEAKK-MEM RIPK1_Mmus LLEKTDLDSGGFGKVSLCYHRSHG-FVILKKVYTGPNR-----AEYNEVLLEEG-KMMHR RIPK2_Mmus LADLHYLSRGASGTVSSARHADWRVRVAVKHLHI-HT---PLLDSERNDILREAEI-LHK RIPK3_Mmus LKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSK-------------KISWEVKA-MVN SgK288_Mmus ---WHLVASGGFSKVFQARHKRWRTQYAIKCSPCLQK---ETTSSEVTCLFEEAVK-MEK ANKK2_Spur ------LGGGSFGEVFKAVHKVHG-DVAVKLAKPGKGDQL------K-MHQKEARKHGLS ANKK1_Spur ------LGGGSFGEVYKAVHKVHG-DVAVKLAKPGKEDQV------VLMYQKEAGKHVLS ANKK3_Spur ------LGGGSFGEVYKATHAVHG-DVAVKLAKPGKERQV------E-MYQKEARKHENS ANKK6_Spur ------LGGGSFGEVFKATHKVHG-EVAVKLAKPGXXXXXXXXXXXXXXXXXXXXXXX-- ank2_Spur ------LGGGSFGEVYKATHTVHD-DVAVKLAKPGKEGQV------V-MYQKEARKHENS ANKK5_Spur ------LGGGSFGEVFKATHAVHG-DVAVKLAKG----QV------V-MYQKEAQKHENS ank1_Spur ------LGGGSFGEVFKAVHAVHG-DVAVKLAKPGKERQLEMYKKQVVMYQKEAQKHENS ANKK4_Spur ------LGGGSFGEVYKATHAVHG-DVAVKLAKPGKEDQV------K-MYKKEARKHENS : *. . * * :* SgK288_Hsap IKFQHIVSIYGVCKQ---------PLGIVMEFMANGSLEKVLSTH--------------- RIPK3_Hsap LDNEFVLRLEGVIEKVNW-DQD-PKPALVTKFMENGSLSGLLQSQ--------------- RIPK2_Hsap ARFSYILPILGICNEP-------EFLGIVTEYMPNGSLNELLHRK-T------------- RIPK1_Hsap LRHSRVVKLLGVIIEE-------GKYSLVMEYMEKGNLMHVLKAE--------------- ANKRD3_Mmus AKFRYILPVYGICQE---------PVGLVMEYMETGSLEKLLASE--------------- ANKRD3_Hsap AKFRYILPVYGICRE---------PVGLVMEYMETGSLEKLLASE--------------- RIPK1_Mmus LRHSRVVKLLGIIIEE-------GNYSLVMEYMEKGNLMHVLKTQ--------------- RIPK2_Mmus ARFSYILPILGICNEP-------EFLGIVTEYMPNGSLNELLHRK-T------------- RIPK3_Mmus LRNENVLLLLGVTEDLQW-DFV-SGQALVTRFMENGSLAGLLQPE--------------- SgK288_Mmus IKFQHIVSIYGVCKQ---------PLGIVMEFMASGSLEKTLPTH--------------- ANKK2_Spur LTCDYIVAIKGFVKCEEDTCPC-GLLGIVMQYMENGSLWDFRISEWQ------------- ANKK1_Spur LTSNHIVSIKGFVQCEKAACDCGCLIGIVMEYMKHGSLWDFRISKWQ------------- ANKK3_Spur LICEHIVPIKGFVECEDDACNC-GLIGIVMKYMENGSLWDFRTTKWQ------------- ANKK6_Spur -----XXXXXXXXXXXXXXXXX-XLFGIVMKYMENGSLWDFRKRRWQ------------- ank2_Spur LICEHIVPIKGFVECEDDACNC-GLIGIVMKYMENGSLWDFRTTKWL------------- ANKK5_Spur LICEHIVSIKGFVECKDDACTC-GLIGIVMTYMENGSLWDFRTTKWL------------- ank1_Spur LKCEHIVPIKGFVQCEDKACDC-ELFGIVIQYMKNGSLWNFRTTKWRQHPDHLDFRTTKL ANKK4_Spur LICEHIVPIKGFVECEDDACNC-GLIGIVMKYMENGSLWDFRTTKWQ------------- .:* :* *.* . SgK288_Hsap ---SL-CWKLRFRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKW RIPK3_Hsap --CPR-PWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTF RIPK2_Hsap -EYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKW RIPK1_Hsap --MST-PLSVKGRIILEIIEGMCYLHGK--GVIHKDLKPENILVDNDFHIKIADLGLASF ANKRD3_Mmus ---PL-PWDLRFRIVHETAVGMNFLHCMSPPLLHLDLKPANILLDAHYHVKISDFGLAKC ANKRD3_Hsap ---PL-PWDLRFRIIHETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFGLAKC RIPK1_Mmus --IDV-PLSLKGRIIVEAIEGMCYLHDK--GVIHKDLKPENILVDRDFHIKIADLGVASF RIPK2_Mmus -EYPDIAWPLRFRILHEIALGVNYLHNMNPPLLHHDLKTQNILLDNEFHVKIADFGLSKW RIPK3_Mmus --CPR-PWPLLCRLLQEVVLGMCYLHSLNPPLLHRDLKPSNILLDPELHAKLADFGLSTF SgK288_Mmus ---SL-CWPLKLRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDNNMHVKISDFGLSKW ANKK2_Spur -PFPD-LWPLTNRMVYQISCGMHFLHSK--NIIHRDLKLENVLVDGDLHVKIADLGLATN ANKK1_Spur -DRPD-LWPLTNRMVHQISSGMHFLHSK--DIIHRDLKLENVLVDGNLNVKVADLGLATN ANKK3_Spur -QHPD-LLPLTNRMVYEMSSGMQFLHSK--DIIHRDLKLENVLVDGDLHVKIADLGLATN ANKK6_Spur -DHPD-LWPLTNR-VYEISCGMHFLHSN--DIIHRDLKLENVLVDGNLHAKIADLGLAAD ank2_Spur -QHPD-LLPLINRMVYEMSSGMQFLHSK--DIIHRDLKLENVLVDGDLHVKIADLGLATN ANKK5_Spur -HHPD-LWPLTNRMIYQISCGMHFLHSN--DIIHRDLKLENVLVDGDLNVKISDLGLATN ank1_Spur LHHPD-LWPLTNRMVYQISRGMHFLHSK--YIIHRDLKLENVLVDRNLNVKIADLGLATN ANKK4_Spur -QHPD-LLPLTNRMVYEMSSGMQFLHSK--DIIHRDLKLENVLVDGDLHVKIADLGLATN : * : : .: :** ::* *** *:*:* . : *::*:*:: SgK288_Hsap MEQSTRMQ----------YIER-SALRGMLSYIPPEMFLES----NKAPGPKYDVYS-FA RIPK3_Hsap QGGSQSGT-------------GSGEPGGTLGYLAPELFVNV----NRKASTASDVYS-FG RIPK2_Hsap RMMSLSQS---------RSSK-SAPEGGTIIYMPPENYEPG---QKSRASIKHDIYS-YA RIPK1_Hsap KMWSKLNNEEHNELRE-VDGTA-KKNGGTLYYMAPEHLND----VNAKPTEKSDVYS-FA ANKRD3_Mmus NGMSHSHD-----------LSM-DGLFGTIAYLPPERIREK----SRLFDTKHDVYS-FA ANKRD3_Hsap NGLSHSHD-----------LSM-DGLFGTIAYLPPERIREK----SRLFDTKHDVYS-FA RIPK1_Mmus KTWSKLTKEKDNKQKEVSSTTK-KNNGGTLYYMAPEHLND----INAKPTEKSDVYS-FG RIPK2_Mmus RMMSLSQS---------RSYK-SAPEGGTIIYMPPENYEPG---QKSRASVKHDIYS-YA RIPK3_Mmus QGGSQSGS---------GSGSGSRDSGGTLAYLDPELLFDV----NLKASKASDVYS-FG SgK288_Mmus MEQSTQKQ----------YIER-SALRGTLSYIPPEMFLEN----NKAPGPEYDVYS-FA ANKK2_Spur LQTS----------------SG-DRCWGTDSHKPPEAFRTDLPNSTKVVTPKYDVYS-FA ANKK1_Spur LQTS----------------FG-DERCGTNSHKPPEAFRTDLPNSTKVVTPEYDVYS-FA ANKK3_Spur LQTS----------------FG-DRCCGTHSHKPPEAFRTDIPNSIMIGTPKYDV----- ANKK6_Spur LRTS----------------FG-DRCWGTDSHKPPEAFRTDLSKSIKVVNPKYDVYS-FA ank2_Spur LQTS----------------FG-DRCWGTDSHKPPEAFRTDLPNSTK------------- ANKK5_Spur LQTS----------------FG-DRCWGTDSHKPPEAFRTDLPDSTKVVTPKYDVYREFE ank1_Spur LQTS----------------SV-L------------------------------------ ANKK4_Spur LQTS----------------FG-DRCCGTHSHKPPEAFRTDIPNSIMIGTPKYDVYS-FA * SgK288_Hsap IVIWELLTQKKPYSGF-NMMMIIIRVAAGMRPSLQP--VSDQWPSE--AQQMVDLMKRCW RIPK3_Hsap ILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAE--LPQAGPETPGLEGLKELMQLCW RIPK2_Hsap VITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHR---ARMISLIESGW RIPK1_Hsap VVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDD--ITEYCPR-----EIISLMKLCW ANKRD3_Mmus IVIWGVLTQKKPFADEKNILHIMMKVVKGHRPELPP--ICRPRPRA--CASLIGLMQRCW ANKRD3_Hsap IVIWGVLTQKKPFADEKNILHIMVKVVKGHRPELPP--VCRARPRA--CSHLIRLMQRCW RIPK1_Mmus IVLWAIFAKKEPYENVICTEQFVICIKSGNRPNVEE--ILEYCPR-----EIISLMERCW RIPK2_Mmus VIMWEVLSRKQPFEEVTNPLQIMYSVSQGHRPDTSEENLPFDIPHR---GLMISLIQSGW RIPK3_Mmus ILVWAVLAGREAELVDKTSLIRETVCDRQSRPPLTE--LPPGSPETPGLEKLKELMIHCW SgK288_Mmus IVIWEILTQKKPYAGL-NMMTIIIRVAAGMRPSLQD--VSDEWPEE--VHQMVNLMKRCW ANKK2_Spur MTLYELLTGIHPYSDRGFDMMKLLKVEAKQPPCLQP--VPVNAPK-----DLIEVMQECW ANKK1_Spur MTLYELLTGIHPYSDRGFYMMMLLKVDSKQSPCLQP--IPASTPE-----DLIRVMEESW ANKK3_Spur ------------------------------------------------------------ ANKK6_Spur MTLYELLTGIHPYAERGLEMVKVFKL-SDQAPCLKP--VPVNTPT-----PLIKVMTDSW ank2_Spur ------------------------------------------------------------ ANKK5_Spur FVKQQKVDNTTPC--------------------EDP--VPENTPE-----ALIEVMRDSW ank1_Spur -------------------------------------------------------LDLLW ANKK4_Spur MTLYELLTGIHPY----------------------------------------------- SgK288_Hsap DQDPKKRPCF----------------------------L RIPK3_Hsap SSEPKDRPSFQECLPKTD------------------EVF RIPK2_Hsap AQNPDERPSF----------------------------L RIPK1_Hsap EANPEARPTFPGIEE----------------------KF ANKRD3_Mmus HADPQVRPTFQEITSE--------------------TED ANKRD3_Hsap QGDPRVRPTFQEITSE--------------------TED RIPK1_Mmus QAIPEDRPTFLGIEE----------------------EF RIPK2_Mmus AQNPDERPSF----------------------------L RIPK3_Mmus GSQSENRPSFQDCEPKTN------------------EVY SgK288_Mmus DQDPKKRPCF----------------------------L ANKK2_Spur SYEANERPNFREIRDRVKN-LGTEPTYASLGFYLGEQVV ANKK1_Spur SYEPNDRPNFREITE----------------------WV ANKK3_Spur --------------------------------------Y ANKK6_Spur RYAANSRPAFIEITDWVKNQLNIKPTHRSLG---ICLGE ank2_Spur --------------------------------------I ANKK5_Spur SYEANDRPN-----------------------------F ank1_Spur --------------------------------------G ANKK4_Spur --------------------------------------S