CLUSTAL W (1.83) multiple sequence alignment ROR2_Hsap VRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQ ROR1_Hsap VRFMEELGECAFGKIYKGHLYLPGM-DHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELH Ror_Dmel VEFLEELGEGAFGKVYKGQLLQPN--KTTITVAIKALKENASVKTQQDFKREIELISDLK cam-1_Cele LSVREKIGEGQFGVVHSGIYTSGLFAPEPMAVAVKKCRHDATNAERAQLEQEIRAVATFD ROR1_Mmus VRFMEELGECTFGKIYKGHLYLPGM-DHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELH ROR2_Mmus VRFMEELGEDRFGKVYKGHLFGPAPGEPTQAVAIKTLKDKAEGPLREEFRQEAMLRARLQ ROR_Spur IKFSEALGDGTFGKVWRGELMGLNNQYSCTSIVIKTLDKEASPALQQDYRNETSVMASLN : . * :*: ** : * :.:* . : ..* : :. ROR2_Hsap HPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGS-TDDDRTVKSALEPPD ROR1_Hsap HPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGD Ror_Dmel HQNIVCILGVVLNKEPYCMLFEYMANGDLHEFLISNSPTE------------GKSLSQLE cam-1_Cele HPNVIKLIGVCYMDNSLLAVFEYMVHGDLHELLKVRVPPADHDMG-------GITEANAE ROR1_Mmus HPNIVCLLGAVTQEQPVCMLFEYMNQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGD ROR2_Mmus HPNIVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGS-TDDDRTVKSALEPPD ROR_Spur HPNIITLLGVCTKEKPNCMLFEFLPHGDLHEFLVRHSPNSDVGFGSGDD-DTQSSLDASD * *:: ::*. .:. :*.: :*****:* . * : : ROR2_Hsap FVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGN ROR1_Hsap FLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSK Ror_Dmel FLQIALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYSSDYYRVQSK cam-1_Cele FLYIATQIALGMEYLASMSFVHRDLATRNCLVGDTRTIKIADFGLMRTSYGSDYYKMLHR ROR1_Mmus FLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSK ROR2_Mmus FVHVVAQIAAGMEFLSSHHVVHKDLATRNVLVYDKLNVRISDLGLFREVYSADYYKLMGN ROR_Spur FLNIAIQIVSGMDYLSSRHFVHRDLAARNCMVGEHHQIKITDFGLARDIYSGDYYRMPSQ *: :. ** **::*:: **:***:** :: : ::*:*:** * *..***:: . ROR2_Hsap SLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVL ROR1_Hsap SLLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLL Ror_Dmel SLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSRQLL cam-1_Cele SWMPVRWMSKEAIEQGRFSEASDVWSFGVTLWEIWSFGRQPYEGASNQQVIELVANRHLL ROR1_Mmus SSLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLL ROR2_Mmus SLLPIRWMSPEAVMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRSRQVL ROR_Spur AVLPIRWMSPEAIMFGRFTVESDIWSFGVVLWEIYSYGLQPFYGYNNNEVIEMIRTRHIL : :*:***. *:: *:*: **:**:**.***::*:* **: * .*::*:::: .*::* ROR2_Hsap PCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTS ROR1_Hsap PCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSWEGLSSHTSSTTPSGGNATTQTT Ror_Dmel SAPENCPTAVYSLMIECWHEQSVKRPTFTDISNRLKT----------------------- cam-1_Cele ECPHNCPTNIYSLMVECWHENIERRPTFSEIRSRLQSW---------------------- ROR1_Mmus PCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSWEGLSSHTSSTTPSGGNATTQTT ROR2_Mmus PCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRSWGNLSNYNSSAQTSGASNTTQTS ROR_Spur PSPSGCPQYIYALMTECWSEIPARRPPFKVISTRLRALDT-------------------- .. .** :*:** *** * :** *. * **:: ROR2_Hsap SLSTSPVS ROR1_Hsap SLSASPVS Ror_Dmel -------W cam-1_Cele -------S ROR1_Mmus SLSASPVS ROR2_Mmus SLSTSPVS ROR_Spur -------V