CLUSTAL W (1.83) multiple sequence alignment RYK_Hsap ITLKDVLQEGTFGRIFHGILID-----------EKD-PNKEKQAFVKTVKDQASEIQVTM lin-18_Cele FQSLPLDMEGTFGEVRYAIWRQVDDVLNGDVDDEEDTFCNQEAVYTKTLKNNASPIQLDR drl_Dmel VRLSCLVQEGNFGRIYRGTYN------------------DCQEVLVKTVAQHASQLQVNL dnt_Dmel VRLSSLLQEGTFGRVYRGTYN------------------DTQDVLVKTVAQHASQMQVLL Drl-2_Dmel LSYEELVKEGTFGRIYAGKLG------------------ESCEALVKTVIDGASLTQVAC RYK_Mmus ITLKDVLQEGTFGRIFHGILVD-----------EKD-PNKEKQTFVKTVKDQASEVQVTM Ryk_Spur ITLGEVLLEGTFGRVHQGVLIS-----------AT--GDSEQDVFIKTVTDHSSEEQRHL AqueK403_Aque ------------------------------------------------------------ AqueK404_Aque GTLKTLLLKTREGG---------------------------------------------- AqueK405_Aque GTLKTLLLKTREGG---------------------------------------------- AqueK406_Aque GTLKTLLLKTREGG---------------------------------------------- RYK_Hsap MLTESCKLRGLH-HRNLLPITHVCI--------EEGEKPMVILPYM-NWGNLKLFLRQCK lin-18_Cele FLSDALLFYNITPHQNLSQVACVASFGRFDRPETVTDFPLVCYRHQ-GFGNLKKFLTICR drl_Dmel LLQESMMLYEAS-HPNVLSVLGISI--------EDYATPFVLYAATGSVRNLKSFLQ--- dnt_Dmel LLQEGMLLYGAS-HPGILSVLGVSI--------EDHTTPFVLYPALNNTRNLKQFLL--- Drl-2_Dmel LLQDASLLIGVS-HQHILAPLLANT--------ELPGPPEIAYPHP-SKGNLKMYLQKSR RYK_Mmus MLTESCKLRGLH-HRNLLPITHVCI--------EEGEKPMVVLPYM-NWGNLKLFLRQCK Ryk_Spur LVKESCLLQGLS-HKNILPLLHVCF--------SD--PPFILEAFM-KLGNLKQFLKNGR AqueK403_Aque ------------------------------------------------------------ AqueK404_Aque ---------------------------------------GIMLPGN-------------- AqueK405_Aque ---------------------------------------GIMLPGN-------------- AqueK406_Aque ---------------------------------------GIMLPGN-------------- RYK_Hsap LVE-ANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDD---TLQVKITD lin-18_Cele HGDKTKGAQTLRTHQLVSLATQVSSAVAHIHKYRIVHNDIAARNCLIAEVNGRLQVQLCD drl_Dmel ---DPSYARSVTTIQTVLMGSQLAMAMEHLHNHGVIHKDIAARNCVIDD---QLRVKLTD dnt_Dmel ---DPACARTVTTIQIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDD---QLRVKLSD Drl-2_Dmel -----ESSTALSTRQLVEFGLHITKGLAYLHSLGIVHKDIATRNCYLDE---ESYVKICD RYK_Mmus LVE-ANNPQAISQQDLVHMAIQIACGMSYLARREVIHRDLAARNCVIDD---TLQVKITD Ryk_Spur IGP-GDKHQAISTRDLVHLAIQITHGMMYLGKKRLVHKDLATRNCVIDE---DYNLKITD AqueK403_Aque ------------------------------------------------------------ AqueK404_Aque ---NSGQCTYISTHDLVFISEQVARGMYHLTRKGQVHKDLACRNIYIHE---NLHVKIGD AqueK405_Aque ---NSGQCTYISTHDLVFISEQVARGMYHLTRKGQVHKDLACRNIYIHE---NLHVKIGD AqueK406_Aque ---NSGQCTYISTHDLVFISEQVARGMYHLTRKGQVHKDLACRNIYIHE---NLHVKIGD RYK_Hsap NALSRDLFPMDYHCLGDN-------ENRPVRWMALESLVNNEFSSASDVWAFGVTLWELM lin-18_Cele SALSRDLFPADYHCLGDN-------ENRPLKWMSPEAIANELYSSAADVWSLGVLLWELM drl_Dmel SALSRDLFPGDYNSLGDG-------EYRPIKWLSLEALQKSHYNEGSDVWSFGVLMWEMC dnt_Dmel SSLSRDLFPSDYNCLGDS-------ENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELC Drl-2_Dmel SALSRDLFPDDYDCLGDN-------ENRPLKWLSLESLQKRVYATQGDVWALGVTYWELV RYK_Mmus NALSRDLFPMDYHCLGDN-------ENRPVRWMALESLVNNEFSSASDVWAFGVTLWELM Ryk_Spur NALSRDLFPSDYHCLGDN-------ENRPVKWMAVESLVHKKFSHASDVWSFGVTLWELV AqueK403_Aque -------------------------------------------------WSFGVVLWEIM AqueK404_Aque RGLSWDFYPEDYNTIEERGGGGDETIAYPVKWMAAEVLSDKRYSSSSDVWSFGVVLWEIM AqueK405_Aque RGLSWDFYPEDYNTIEERGGGGDETIAYPVKWMAAEVLSDKRYSSSSDVWSFGVVLWEIM AqueK406_Aque RGLSWDFYPEDYNTIEERGGGGDETIAYPVKWMAAEVLSDKRYSSSSDVWSFGVVLWEIM *::** **: RYK_Hsap TLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLV--- lin-18_Cele SLGGSPHAEIDPEEVYTMILKGKRLQQPNNCPDQLYEVMLCCWRVLSEDRPSSEQV---- drl_Dmel TLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERPSFSQLQ--- dnt_Dmel TSAKQPYAEVDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQLQ--- Drl-2_Dmel TLAQMPHEEVDIFELTNYLAAGFRLEQPVNCPDEFFTVMNCCWHCEAKQRPTPSQLL--- RYK_Mmus TLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLV--- Ryk_Spur TLGQTPYMDLDPFEMATFLKSGYRMPQPPSCPDE-------------------------- AqueK403_Aque TRGKTPYEDVLPENMLNYLTTGHRLPQPKNCPDDLRD----------------------- AqueK404_Aque TRGKTPYEDVLPENMLNYLTTGHRLPQPKNCPDDLFSLMGWCWALTPSDRPRFSHLTVRL AqueK405_Aque TRGKTPYEDVLPENMLNYLTTGHRLPQPKNCPDDLFSLMGWCWALTPSDRPRFSHLTVRL AqueK406_Aque TRGKTPYEDVLPENMLNYLTTGHRLPQPKNCPDDLFSLMGWCWALTPSDRPRFSHLTVRL : . *: :: :: : * *: ** .***: RYK_Hsap -QCL lin-18_Cele ---V drl_Dmel -ICL dnt_Dmel -SCL Drl-2_Dmel -SYL RYK_Mmus -QCL Ryk_Spur ---L AqueK403_Aque ---L AqueK404_Aque KEFY AqueK405_Aque KEFY AqueK406_Aque KEFY