CLUSTAL W (1.83) multiple sequence alignment SCYL3_Hsap ----------------A---V-------YPAVL-Q-DGK-FASVFVYKRE---------- SCYL2_Hsap FDVGRHIASGGNGLAWK---I-------FNGTKKS-TKQ-EVAVFVFDKKLID--KYQKF SCYL1_Hsap ---------------WA---L-------HRGRKKA-TGS-PVSIFVYDVKPG-------- SCY1_Scer KQ----------FENYL---L-------HYGIIKSKSGS-RDKVLI-------------- CG1973_Dmel -------------SIWT---L-------HKAKRKT-TLE-EVSVFVYDIRSG-------- CG1951_Dmel -------------LMWK---V-------YNGHKKS-TKQ-EVSVFVFEKKSLE--RWSKD CG14163_Dmel -------------LVWR---I-------HDAYRKS-DNK-ECSVFIFEKKIAE--KLHKP SCYL1_Mmus ---------------WI---L-------HRGRKKA-TGS-AVSIFVYDVKPG-------- SCYL2_Mmus FDVGRHIASGGNGLAWK---I-------FNGTKKS-TKQ-EVAVFVFDKKLID--KYQKF SCYL3_Mmus ----------------A---V-------YPAIL-Q-DGK-CASVFVYKRE---------- W07G4.3_Cele ----------------S---I-------GNSFKKA-EPGELATIF-WDNR---------- ZC581.9_Cele ------------------------------------------------------------ Scy1_Ddis ---------------WT---L-------HSGTKKE-DGS-AVSIFSFDIKK--------- Scy2_Ddis G----------QDKFWK---I-------YQSTKKT-TNT-ECSLFVFEKKLYE--KVSKS 3125_Tthe ------------------------------------------------------------ SCYL2_Spur ------------------------------------------------------------ SCYL3_Spur ------------------------------------------------------------ SCYL1_Spur ADVNKAGSAAQNPSSWTGWAMTSLTSRLYRGGGTK-PAA-PGTG------GPQ--QAKPD CG1344_Dmel ----------------M---L--------SV-F-E-GKV-FVKAHVW-SN---------- CC1G_05159_Ccin ---------------WK---V-------QPATHKV-TGK-RVSVWSFDKRGPEMERLGVA CC1G_02059_Ccin ---------------YT---L-------YDGTKRD-DGS-PVSIFEYELS---------- AqueK202_Aque ---------------WN---V-------HFGNRKP-AND-PVLVFIFNFANK-------- AqueK203_Aque ---------------WM---Y-------S------------------------------- AqueK204_Aque ------------------------------------------------------------ AqueK205_Aque ------------------------------------------------------------ SCY1_Smoe ------------------------------------------------------------ GK067_Glam GTF----------GIWH---M-------YSGRNKK-SNA-FGTVFVIEKKLVE--KFVFG SCYL3_Hsap -----NED----KVNKAAKHLKT-LRHPCLLRFLS------------------------- SCYL2_Hsap E-KDQIID----SLKRGVQQLTR-LRHPRLLTVQH------------------------- SCYL1_Hsap --AEEQTQ----VAKAAFKRFKT-LRHPNILAYID------------------------- SCY1_Scer ---QEAYE----ILRNQANNLAK-LKHPNILTLIE------------------------- CG1973_Dmel --SDTKCE----LAKAALKRLKT-LRHPSILQYLD------------------------- CG1951_Dmel D-RETMLE----TLRRGVQQLTK-IRHPHVLTVQH------------------------- CG14163_Dmel RRKETITE----LLKSSVKTLER-FRHPRILQIYH------------------------- SCYL1_Mmus --AEEQTQ----VAKAAFKRLKT-LRHPNILAYID------------------------- SCYL2_Mmus E-KDQIID----SLKRGVQQLTR-LRHPRLLTVQH------------------------- SCYL3_Mmus -----NED----KVNKAAKHLKT-LRHPCLLRFLS------------------------- W07G4.3_Cele ------SS----TLKQQAQKLKT-MRHPNIITYLD------------------------- ZC581.9_Cele --------------------------------MEH------------------------- Scy1_Ddis --NPSKLE----VAKNGFKRAKT-TRHPNVLKYLD------------------------- Scy2_Ddis N-LENVIT----FLKKEATTLQR-LRHPSILQVVS------------------------- 3125_Tthe -------------LKKEATSMMK-IRHPNIVNLVE------------------------- SCYL2_Spur ------------------------------------------------------------ SCYL3_Spur --------------------LKV-LRHPTILKFFA------------------------- SCYL1_Spur T---AAS----------KP-APAKDERPSSMTRVDGSRDRDSDSDYGNEGGKEGDADGWN CG1344_Dmel -----GVG----PIERAIKNLMV-YRHPYILKYIA------------------------- CC1G_05159_Ccin G-KDRVLE----VLKNEASALSR-LRHPSILEMVE------------------------- CC1G_02059_Ccin --GRNTRA----LAQNALRKLRT-TRHPDVLKFMD------------------------- AqueK202_Aque --SDDEIR----QARSAHLRLKT-LRHPNILRYID------------------------- AqueK203_Aque ------------------------------------------------------------ AqueK204_Aque ------------------------------------------------------------ AqueK205_Aque ------------------------------------------------------------ SCY1_Smoe --------------------MLK-LRHPGVLRVVQ------------------------- GK067_Glam K-ADNLSKQFFSFINKDAA-VPG-KNAKEILIILE------------------------- SCYL3_Hsap --------------------------------------------CTVEA-DGIHLVTERV SCYL2_Hsap --------------------------------------------PLEESRDCLAFCTEPV SCYL1_Hsap --------------------------------------------GLETE-KCLHVVTEAV SCY1_Scer --------------------------------------------PLEEHSKNFMFVTEFV CG1973_Dmel --------------------------------------------SLETD-KMLYVATEAV CG1951_Dmel --------------------------------------------PLEESRDSLAFATEPV CG14163_Dmel --------------------------------------------TVEESADTLAFASEPI SCYL1_Mmus --------------------------------------------GLETE-KCLHIVTEAV SCYL2_Mmus --------------------------------------------PLEESRDCLAFCTEPV SCYL3_Mmus --------------------------------------------CTVEA-DGIHLVTERV W07G4.3_Cele --------------------------------------------SIELE-GTFYLVTEKC ZC581.9_Cele --------------------------------------------SLEETKDYISFATEQI Scy1_Ddis --------------------------------------------GLETE-TNIYIVTEPI Scy2_Ddis --------------------------------------------VMEETKTHIHFATEPI 3125_Tthe --------------------------------------------PVIEDKYSMAFVTERV SCYL2_Spur ------------------------------------------------------------ SCYL3_Spur --------------------------------------------SCNNVD-STYLVT--- SCYL1_Spur DNDNWGNMEEEEETTTAQETKETSEWDSQGWGDDYDDDMDSLETPAPKSSKSTSYATSSI CG1344_Dmel --------------------------------------------TWEKS-GRKYLATERV CC1G_05159_Ccin --------------------------------------------PLEETRIELVFATEPV CC1G_02059_Ccin --------------------------------------------VVETD-STIHIMTERV AqueK202_Aque --------------------------------------------GVELL-DSIYMMTEEA AqueK203_Aque ------------------------------------------------------------ AqueK204_Aque ------------------------------------------------------------ AqueK205_Aque ------------------------------------------------------------ SCY1_Smoe --------------------------------------------ALDESKTAMAMVTEPI GK067_Glam --------------------------------------------QLQEENNCLYYVTEPL SCYL3_Hsap QP-LEVALET-------------------------------------------------- SCYL2_Hsap FASLANVLGNWENLPS------------------------------P------------- SCYL1_Hsap TP-LGIYLKARVE----------------------------------------------- SCY1_Scer TSSLETVFRETDDEEQ-------------------------------------------- CG1973_Dmel DP-LGTYFSKLGS----------------------------------------------- CG1951_Dmel FASLANVVGDNVR----------------------------------------------- CG14163_Dmel FASLSNVLAFHESKTYEATNVAPAAGGAAASQAQAAANTL-----PQ------------- SCYL1_Mmus TP-LGTYLKARAE----------------------------------------------- SCYL2_Mmus FASLANVLGNWENLPS------------------------------S------------- SCYL3_Mmus QP-LEVALET-------------------------------------------------- W07G4.3_Cele KP-LELYLKEAGL----------------------------------------------- ZC581.9_Cele FGNLENVVT--------------------------------------------------- Scy1_Ddis QL-LDELLEDIR------------------------------------------------ Scy2_Ddis LATLEDLLGYYRQRKKST---------------------VDQSSQSE------------- 3125_Tthe DDNLYNLMKKGDYKA--------------------------------------------- SCYL2_Spur ------------------------------------------------------------ SCYL3_Spur ------------------------------------------------------------ SCYL1_Spur SSSASTAKSKSSALKL-------------------------------------------- CG1344_Dmel RP-LDEVLAQ-------------------------------------------------- CC1G_05159_Ccin LSSLELSIPG-------------------------------------------------- CC1G_02059_Ccin RP-LQSALSSWST----------------------------------------------- AqueK202_Aque TP-LQEVLESATP----------------------------------------------- AqueK203_Aque ------------------------------------------------------------ AqueK204_Aque ------------------------------------------------------------ AqueK205_Aque ------------------------------------------------------------ SCY1_Smoe FASVANVLGNLENVSK-------------------------------------------- GK067_Glam VGTLSSLYKLFGHTCLNV---------------------I-----KRKADHEMLANANPR SCYL3_Hsap -------------LSSAEVCAGIYD---------ILLALIFLHDRGHLTHNNVCLSSVFV SCYL2_Hsap ----ISPDIKDYKLYDVETKYGLLQ---------VSEGLSFLHSSVKMVHGNITPENIIL SCYL1_Hsap ----------AGGLKELEISWGLHQ---------IVKALSFLVNDCSLIHNNVCMAAVFV SCY1_Scer ------NFLQGHVKDNIVVQRGILQ---------LVNALDFVHNRASFVHLNIQPRAIFI CG1973_Dmel ----------DNVQKGLYLAWGIFQ---------ITRALSFLNNDGNLRHNNVSAWSVFV CG1951_Dmel ---------SEKKLYDVEIRHGLLQ---------LFDGLQFLHQDAKIVHRNISAETIVI CG14163_Dmel ----RPAHAKEYNFLDMELKYGFLQ---------LTEALAYLHYSGHVIHRNVCPSSILI SCYL1_Mmus ----------AGGLKEQELSWGLHQ---------IVKALSFLVNDCNLIHNNVCMAAVFV SCYL2_Mmus ----ISPDIKDYKLYDVETKYGLLQ---------VSEGLSFLHSSVKMVHGNVTPENVIL SCYL3_Mmus -------------LSPAEVCAGIYD---------ILLALIFLHDRGHLTHNNVCLSSVFV W07G4.3_Cele ----------TESQKEFVVSWGMFQ---------LLNALKFMHE-AKLSHENLR-KGVFV ZC581.9_Cele ----------DESLDRLEIKLGVLQ---------IIDGMSYLHNSAKMLHGNLTPDAIYV Scy1_Ddis -------------NFENAISWGLYQ-----------EGLSFLNNKCNLTHGNIQSSSIFV Scy2_Ddis ----EGYKKKDFTFEELELKAGIFQ---------ILDGLLFLNQTAKLLHRNISPESIFI 3125_Tthe -----------ICQSELELKLQVEN---------ILKVLQFLHNDVKTAHLGIAPENIFI SCYL2_Spur ----------------------LLQ---------LTDALKFLHNDVHMVHGNITPASIIL SCYL3_Spur ------------------------------------------------------------ SCYL1_Spur -------GGTKKTQDVDFGDWGLDESSVDRKPIKTSSKLSKSQSGSERSTPKGSPKKTMR CG1344_Dmel -------------QTDIEVCLGLRT---------ILCALIFLVEKALARHLNINTQSIYV CC1G_05159_Ccin ----SGRHASLVELDEIEIQKGILQ---------LAKGLSFLHSQAQLIHSNICPESIII CC1G_02059_Ccin -------------KTEQERQDWLLW---------GLHPLTFLNDPCSSTHGAFNTNAIFI AqueK202_Aque -------------PSEHLVSWGIHQ---------IIKSISFLSNDCSLIHNNVAIHSVFV AqueK203_Aque ------------------------------------------------------------ AqueK204_Aque ------------------------------------KSISFLSNDCSLIHNNVAIHSVFA AqueK205_Aque ----------------------LLQ---------LAEGLNFLHNNVKMRHGNLCIDNITI SCY1_Smoe ----TPKELRGLELGLLEIKHGLLQ---------LTETLSFLHNNAQLVHRAISPESVFI GK067_Glam IYSANPFTNLLQYVQPDSIAYGYMT---------LLRSLSILQNDGY-VFGNLTPANIAI SCYL3_Hsap S------------EDGHWKLGGME-------------------------TVCKVSQATP- SCYL2_Hsap N------------KSGAWKIMGFD-------------------------FCVSSTNPSE- SCYL1_Hsap D------------RAGEWKLGGLD-------------------------YMYSAQGNGG- SCY1_Scer N------------ENSDWKISGLG-------------------------YLVKIPPGTNT CG1973_Dmel N------------ASGEWKLGSLE-------------------------YVSAADGN-P- CG1951_Dmel N------------KNRSWKLFGFD-------------------------FCIANQPATD- CG14163_Dmel T------------KRGIWKLAGME-------------------------YVERMNEN-D- SCYL1_Mmus D------------RAGEWKLGGLD-------------------------YMYSAQGNGG- SCYL2_Mmus N------------KSGAWKIMGFD-------------------------FCVSSSNPSE- SCYL3_Mmus S------------EDGHWKLGGME-------------------------TVCQVPQATP- W07G4.3_Cele T------------AGGDWKIGGLH-------------------------LVTGFTS---- ZC581.9_Cele T------------ATKTWKIGGFS-------------------------FAVNAKEPNC- Scy1_Ddis N------------KGGDWQIGGLD-------------------------FVSDVKDINN- Scy2_Ddis T------------KDLKWKLGGLG-------------------------FTCSIETKEP- 3125_Tthe V-------------NGQWKI---------------------------------------- SCYL2_Spur N------------SNGAWKLAGFD-------------------------FVIPSSSPPD- SCYL3_Spur ------------------------------------------------------------ SCYL1_Spur NEADLGGWDDDDDDAGGW--GSMDAVADDDGGGGGGGWGDDEEWGAMDDLSVSSTKPAQK CG1344_Dmel T------------ESGSWRLAGFE-------------------------YVWRATDVNK- CC1G_05159_Ccin N------------SSGDWKISGLG-------------------------VTIPLLTNGNP CC1G_02059_Ccin S------------PSGEWKLGGFE-------------------------LLS-------- AqueK202_Aque D------------AAGEWKLSGVE-------------------------WMYSYNDTN-- AqueK203_Aque -----------------------------------------------------YNDTN-- AqueK204_Aque D------------AAGEWKLSGVE-------------------------WM--------- AqueK205_Aque S------------TNGDWKLAGFN-------------------------FASSIESETP- SCY1_Smoe T------------STGSWKFGGFG-------------------------FAATVEQTAAE GK067_Glam T------------PRGEWRLVGFS-------------------------CCLPGGI---- SCYL3_Hsap --EF-LRSIQSI------------------R-DPAS-I-PPEEMSPEFT-----TLPECH SCYL2_Hsap --QEPKFPCKEW----------------DPN-LPSLCLPNPEYLAPEYILS------VSC SCYL1_Hsap --GPPRKGIPEL----------------------------EQYDPPELADSSGR--VVRE SCY1_Scer ----SEYFLPQY----------------DPR-VPPFMHLQLNYTAPEIVFE------NTL CG1973_Dmel --MPPAKIPVTL----------------------------EVYDSPEKNDPSKL--KAAT CG1951_Dmel --GTPHWPFREY----------------TTS-LHVLAQPSLEYTAPELALN------SVN CG14163_Dmel --LNSSIPCPPW----------------SNR-VSKMAQPNLDFMAPETQST------SKC SCYL1_Mmus --GPPSKGIPEL----------------------------EQYDPPELADSSSR--AVRE SCYL2_Mmus --QEPKFPCKEW----------------DPN-LPSLCLPNPEYLAPEYILS------VSC SCYL3_Mmus --EF-LRNIQSV------------------R-DPAS-I-PPEEMSPEFS-----GLPESH W07G4.3_Cele ------------------------------------------------------------ ZC581.9_Cele ------YPCYPW----------------TKK-LPPCLQPDLDFLAPENLAPG----QTTV Scy1_Ddis --SI-LRNHNDL-------------------------I-PNKYKSPEIMKSQWQQIQQSP Scy2_Ddis ----P-ISNLSLQDLREYQYISGGGGGESSN-NSNYILPQLDYLAPEFISQ------RKF 3125_Tthe ------------------------------------------------------------ SCYL2_Spur --QPAIFPLREL----------------MND-VSAVLQPNLNYLAPEYLLT------QSC SCYL3_Spur ------------------------------------------------------------ SCYL1_Spur -SKPTSKPPPGW----------------GDN-LD-FAEDKSHTPASSYNWG------QEQ CG1344_Dmel --QL-LDLAHSF------------------I-DL-----------------------TIH CC1G_05159_Ccin ----TRWEFPTF----------------DGR-VPAYIQRSFDYMAPEYALDE------QL CC1G_02059_Ccin ------------------------------------------------------------ AqueK202_Aque ---IPLKTFQSL----------------------------NKYDPPENMKQAKR---KTE AqueK203_Aque ---VPLKTFQYL----------------------------NKYDPPENMKQAKR---KTE AqueK204_Aque ------------------------------------------------------------ AqueK205_Aque -----GYSFKET--------------------KAFPLHPTLNYLAPEVVLS------NTV SCY1_Smoe AGAGASFLYPEY----------------DVDEVVMPLQPPLNYTAPELTRSN----G-NP GK067_Glam --------NFEF----------------SSD-SGALTRPCAHFMSPSMLQN------KKA SCYL3_Hsap GHARDAFSFGTLVESLLTILNEQVS-A--DVL---------------------------- SCYL2_Hsap ETASDMYSLGTVMYAVFNKGKPIFEVNKQDIYK---------SFSRQLD----QLSRL-- SCYL1_Hsap KWSADMWRLGCLIWEVFNGPLPRAAAL--RNP---------------------------- SCY1_Scer TFKNDYFSLGLLIYFLYTGK-DLFRSENS--TS---------EYKLEYNKFESKISTM-- CG1973_Dmel KCSVDMWGLGCLVWEAFNGVLKQRSNL--KDI---------------------------- CG1951_Dmel TPDSDLFSLGVLIFTIYAG-KPLKMFGSD--YS---------SFRRYAN----DLNQR-- CG14163_Dmel SLLSDMFSLGMVICAVFNNGRPLIQAGNS--TS---------NYAKQME----TLDDL-- SCYL1_Mmus KWSADMWRLGCLIWEVFNGSLPRAAAL--RNP---------------------------- SCYL2_Mmus ETASDMYSLGAVMYAVFNQGRPIFEVNKQDIYK---------SFSRQLD----QLSRL-- SCYL3_Mmus GHARDAYAFGALVDSLLPIFNEQVS-A--DVL---------------------------- W07G4.3_Cele -PQTDLNQLAIVLWEVFNGFNDAITRP--QAP---------------------------- ZC581.9_Cele TSAADVFSLGVLICWIYAGGKRLIDAKSN--LE---------TYHIVVG----QLDAA-- Scy1_Ddis SYSIDSWMLGCLMYECYNGTMTKAEDI--KNL---------------------------- Scy2_Ddis ETNSDLFSIGRLIFELSINLEQKALDSHL--ISQLPKLGVISYYNTMIE----QVRR--- 3125_Tthe ------------------------------------------------------------ SCYL2_Spur DMSSDLFSLGMLMYSVINTGKLFHDCNEN--LS---------TFKQKSE----QLRSL-- SCYL3_Spur ------------------------------------------------------------ SCYL1_Spur ETTPDQDFFGATARSTTTTSKKSLQTTKK--SS-------------PIK----QTASSDT CG1344_Dmel GENFEQFFFSILCEKVLSRKGTDSCIT--DSTP---------HV---------------- CC1G_05159_Ccin LTSSDMYSLGCVVYAVHSKGNPPFKNHGS--LS---------NLRENAG--------K-- CC1G_02059_Ccin ------------------------------------------------------------ AqueK202_Aque KWSRDMWGLGCLLWEVFNGPIHQSSNL--RDT---------------------------- AqueK203_Aque KWSRDMWGLGCLLWEVFNGPIHQSSNL--RDT---------------------------- AqueK204_Aque --SRDMWGLGCLLLEVFNGPIHQSSNL--RDT---------------------------- AqueK205_Aque NEKCDLYSFGMLIFAIYNSGKPLFDCKDN--LR---------TYKQNIE----MTSRI-- SCY1_Smoe GSCSDIFSLGCLIYHLLSRE-PLVLCKNN--LR---------AYKAKVQ----Y---L-- GK067_Glam SKVSDAFQLASCIYTIF------------------------------------------- SCYL3_Hsap -------------------SSFQQTL---HSTLLNPIPKCRPALCT-LLS-----HDFF SCYL2_Hsap -------------G-SSSLTNIPEEVREHVKLLLNVTPTVRPDADQ-MTK-----IPFF SCYL1_Hsap -------------------GKIPKTLVPHYCELVGANPKVRPNPAR-FL---------Q SCY1_Scer -------------SWDNIFSKVPQKLRHCIPKLINRDIYSRYDNITLILD-----SEFF CG1973_Dmel -------------------EHIPKSLQSLYCELVGASPSNRPNPAD-IITRCRKPGGFF CG1951_Dmel -------------K-YPPMNAVPSELTESLKALLHPSANLRPKLHE-LKQ-----IAYF CG14163_Dmel -------------V-HKLMPRLPIALQEATSRMASRDATARPTAQL-LQL-----IKYF SCYL1_Mmus -------------------GKIPKSLVTHYCELVGANPKVRPNPAR-FL---------Q SCYL2_Mmus -------------G-SSSLTSIPEEVREHVKLLLNVTPTVRPDADQ-MTK-----IPFF SCYL3_Mmus -------------------SSFLQIL---HSALLNPMPECRPALST-LLS-----HDFF W07G4.3_Cele -------------------GKIPQRIHELYKK-IGAQSAARLAVFS----------KIS ZC581.9_Cele -------------L-QCISNELGPNLKDSMAKVLSLDVEVRPTVQL-L--------SLI Scy1_Ddis -------------------DQIPKQLHQAYQKSFAVKTESRLNPQK-FL---------E Scy2_Ddis ---------------QSTM-NTQRSDSAKVCTILLGDPMLRGDLEN-FIR-----SSFF 3125_Tthe ----------------------------------------------------------A SCYL2_Spur -------------S-ISLLSSLPDGLKEYVKMLLSTTPTIRPDADQ-LG--------KV SCYL3_Spur ----------------------------------------------------------E SCYL1_Spur SGWGAKDSGWDDDGWGSVDNEGGSNDSGLSKAELAKKKREERRLQ-REKE-----LQEK CG1344_Dmel -------------------HEFREYC---STHLKHQNTKLRPRLSA-ILL-----HPYF CC1G_05159_Ccin -------------P-LPGMERWEQDLQSLVRSLVTRHATSRPTPQT-LSS-----HPFF CC1G_02059_Ccin ----------------------------------------------------------N AqueK202_Aque -------------------SKFPKSLSSHYLQCVNANPMARPNPSE-LLQSL-KERGGY AqueK203_Aque -------------------SKFPKSLSSHYLQCVNANPMARPNPSE-LL---------Q AqueK204_Aque -------------------SKFPKSLSSHYLQCVNANPMARPNPSE-LL---------Q AqueK205_Aque -------------S-ESMLGDTPFPLRSLVRSLLTIEPSVRPDSLQ-IAK-----HEFF SCY1_Smoe -------------A-SASFSKIPPELVHDLKRMLSPAELSRPTASE-FTG-----SPFF GK067_Glam ------------------------------------------------GG-----RPCK