CLUSTAL W (1.83) multiple sequence alignment SRPK2_Hsap YHVIRKLGWGHFSTVWLCWDMQG---------------------------------KRFV SRPK1_Hsap YHVIRKLGWGHFSTVWLSWDIQG---------------------------------KKFV MSSK1_Hsap YHVVRKLGWGHFSTVWLCWDIQR---------------------------------KRFV MSSK1_Mmus YHVVRKLGWGHFSTVWLCWDIQR---------------------------------KRFV SKY1_Scer YILVRKLGWGHFSTVWLAKDMVN---------------------------------NTHV CG8565_Dmel YHVFKKLGWGHFSTVWLCYDTQM---------------------------------DRYC SRPK_Dmel YHVIRKLGWGHFSTVWLCWDLQA---------------------------------MGYV SRPK1_Mmus YHVIRKLGWGHFSTVWLSWDIQG---------------------------------KKFV SRPK2_Mmus YHVIRKLGWGHFSTVWLCWDMQG---------------------------------KRFV spk-1_Cele YHVIRKLGWGHFSTVWLAWDTQD---------------------------------KRFV Sky1_Ddis YQVVDKLGWGHFSTVWLCNDKDTPITTSSSSSSTTTTTTSSSSNGNGNGNGGNVIGYKQV 13234_Tthe YTIVQKLGWGHFSTVWLAYDKET---------------------------------DSNV 22244_Tthe YVIIQKLGWGHFSTVWLSKDFKY---------------------------------DTYV 3884_Tthe YVVIQKIGWGHFSTVWLAKDFKY---------------------------------DTYV SRPK_Spur ------------------------------------------------------------ CG11489_Dmel FRVVRKLGWGHFSTVWLCRDLKD---------------------------------EKYV CC1G_15433_Ccin ------LGYGTWGTAWLRRDLVN---------------------------------HQHV CC1G_02719_Ccin YEVVRKLGWGQEANVWLARRYTKDNPK-------------------------D-SKPLYV CC1G_05630_Ccin YKLIHKLGFGGSSTVWLARDQQPDSTT-------------------------P-DAASLV CC1G_06188_Ccin YEVVRKLGWGLYATTWLIKDRRDD---------------------------------AYH CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ITVIRKLGSGPRSSTWLVKHIES---------------------------------STYS CC1G_10260_Ccin YRVVRKLGWGHFSTVWLVKDSQS---------------------------------GVHS CC1G_04899_Ccin YVVVRKLGWGHFSTVWLARDTKM---------------------------------NRHV AqueK134_Aque YQIIRKLGWGHFSTVWLCKDLKC---------------------------------GRFV SRPK_b_Smoe YLVRKKLGWGHFSTVWLSSDRHNENVAGSSDLSLIF-----------------SFFQKNI SRPK_d_Smoe YVVQRKVGWGHFSTVWLAWDTQQK---------------------------------SYV SRPK_a_Smoe YVVQRKVGWGHFSTVWLAWDTQQK---------------------------------RYV SRPK_c_Smoe YLVRKKLGWGHFSTVWLSSDRHNE--------------------------------NKNI GK042_Glam YKVLRKIGYGKFSTVWAAVDMVSG---------------------------------TLR SRPK2_Hsap AMKVVKSAQ--HYTE---TA---------LDEIKLLKCVRE--SDPS------------- SRPK1_Hsap AMKVVKSAE--HYTE---TA---------LDEIRLLKSVRN--SDPN------------- MSSK1_Hsap ALKVVKSAG--HYTE---TA---------VDEIKLLKCVRD--SDPS------------- MSSK1_Mmus ALKVVKSAG--HYTE---TA---------VDEIKLLKCVRD--SDPS------------- SKY1_Scer AMKIVRGDK--VYTE---AA---------EDEIKLLQRVND--ADNT------------- CG8565_Dmel AVKVSKSAQ--VYKE---TG---------IDEIMLFSQMSL--HDQ-------------- SRPK_Dmel AIKIVKSAP--HFAE---TA---------RDEIKILKTVRE--TDPS------------- SRPK1_Mmus AMKVVKSAE--HYTE---TA---------LDEIRLLKSVRN--SDPN------------- SRPK2_Mmus AMKVVKSAQ--HYTE---TA---------LDEIKLLKCVRE--SDPS------------- spk-1_Cele AMKIVKSAE--HYTE---AA---------LDEIKLLLSVRS--ADPN------------- Sky1_Ddis ALKIVRSAR--TYSE---TA---------EDEIKILNAISK--YNA-------------- 13234_Tthe ALKIQKSKK--SYQE---AA---------VDELQLLGDLRK--NEKNEKWLSFIKEMK-E 22244_Tthe ALKIQKSAP--HYLE---AA---------YDEVEILQKVAK--QASNPQWIHQLKEYYKD 3884_Tthe ALKIQKSAP--HYLE---AA---------FDEVEILQKVAR--MSKDPEWMKSLQKYY-- SRPK_Spur ------------------------------------------------------------ CG11489_Dmel ALKVVKSAP--HYIE---TA---------ADEIRLLEAIRD--ADPM------------- CC1G_15433_Ccin TVKIGTP-------RA---L---------ENELRVLKHLKS--LNSK------------- CC1G_02719_Ccin AIRILSAVCSAYVVQ---GP---------SYELYALGWLQD--TDEP------------- CC1G_05630_Ccin ALKVMA--A--HFSDRPPSA---------MQELLVPEKLHALFSESR------------- CC1G_06188_Ccin ALKILNHYG--TLLE---AGEVDDPRRPRFFEREILARVSA--SD--------------- CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ALKIYTAAA--SREE---RG---------LAEEKRLVELRD--VMAY------------- CC1G_10260_Ccin ALKVVKSAG--RYAE---TA---------RDEIKLLSRVAS--VSP-------------- CC1G_04899_Ccin ALKIVKSAP--RYTE---TA---------LDEIKLLQRLIT--SSTPPVAPTP------- AqueK134_Aque ALKVVKSAK--QYME---AS---------LDEIELLRKVAT--ANRA------------- SRPK_b_Smoe ALKIQKSAQ--HYTE---AA---------MDEITILTQISK--GDPE------------- SRPK_d_Smoe ALKVQKSAK--HYTE---AA---------FDEISILKQIAD--GDPS------------- SRPK_a_Smoe ALKVQKSAK--HYTE---AA---------FDEISILKQIAD--GDPS------------- SRPK_c_Smoe ALKIQKSAQ--HYTE---AA---------MDEITILTQISK--GDPE------------- GK042_Glam AIKISRSNP--EDWN---VA---------RNEYDVMCKIHS--KVSELF----------- SRPK2_Hsap ------------------------------------------------------------ SRPK1_Hsap ------------------------------------------------------------ MSSK1_Hsap ------------------------------------------------------------ MSSK1_Mmus ------------------------------------------------------------ SKY1_Scer ----------------------------------------------------------KE CG8565_Dmel ------------------------------------------------------------ SRPK_Dmel ------------------------------------------------------------ SRPK1_Mmus ------------------------------------------------------------ SRPK2_Mmus ------------------------------------------------------------ spk-1_Cele ------------------------------------------------------------ Sky1_Ddis ------------------------------------------------------------ 13234_Tthe ----------K--------------------------------------YP-----DCTE 22244_Tthe QTRSAKQNENSDRAISKRFYKQAATALITKKQKKQIIYNLKLKITKQLNKPLNDK-QKKT 3884_Tthe ----------------------------------------------------EGE-KRKS SRPK_Spur ------------------------------------------------------------ CG11489_Dmel ------------------------------------------------------------ CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ----------------------------------------------------------AI CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin ------------------------------------------------------------ CC1G_04899_Ccin ----------E--------------------------------------NP-NPPPSPSH AqueK134_Aque ------------------------------------------------------------ SRPK_b_Smoe ------------------------------------------------------------ SRPK_d_Smoe ------------------------------------------------------------ SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe ------------------------------------------------------------ GK042_Glam ----------------------------------------------------------SD SRPK2_Hsap -DPN-KDM-VVQLIDDFKIS-GMNGIHVCMVFEVL-GHHLL---KWIIKSN-----YQG- SRPK1_Hsap -DPN-REM-VVQLLDDFKIS-GVNGTHICMVFEVL-GHHLL---KWIIKSN-----YQG- MSSK1_Hsap -DPK-RET-IVQLIDDFRIS-GVNGVHVCMVLEVL-GHQLL---KWIIKSN-----YQG- MSSK1_Mmus -DPK-RET-IVQLIDDFRIS-GVNGVHVCMVLEVL-GHQLL---KWIIKSN-----YQG- SKY1_Scer DSMG-ANH-ILKLLDHFNHK-GPNGVHVVMVFEVL-GENLL---ALIKKYE-----HRG- CG8565_Dmel -HKY-RSH-VVGFYDFFEIT-GPHGRHICLVLEVL-GDNLL---KVIERCF-----YKG- SRPK_Dmel -NPR-RHK-TVQMLDDFKIT-GVNGTHICMVFEVL-GDNLL---KLIRKSN-----YRG- SRPK1_Mmus -DPN-GEM-VVQLLDDFKIS-GVNGTHICMVFEVL-GHHLL---KWIIKSN-----YQG- SRPK2_Mmus -DPN-KDM-VVQLIDDFKIS-GMNGIHVCMVFEVL-GHHLL---KWIIKSN-----YQG- spk-1_Cele -DIG-CHK-VVQLLDEFTVT-GINGQHVAMVFEVL-GCNLL---KLIIRSN-----YRG- Sky1_Ddis ---Q-DKC-VARLLDHFTHR-GPNGRHYCMVFELL-GNNLL---DLIKHHR-----YRG- 13234_Tthe FNEN-EQY-CVKLLDNFVHF-GVHGKHYCSTFEIM-GPNLL---DLIQHFD---DYKKN- 22244_Tthe FTRD-DCQ-VVQLLNSFVFR-GPYGNHFCMVFEIL-GVNLL---EIIKRYN-----YKG- 3884_Tthe FNKD-DCQ-VVQLLNSFVFK-GPYGNHFCFVFEIL-GVNLL---EVIKRYN-----YSG- SRPK_Spur ------------------------------------------------------------ CG11489_Dmel -DVK-RER-IVRLMNHFTVR-GVNGMHTCLVFEAL-GCSLY---KLIVKNN-----YQG- CC1G_15433_Ccin -HFG-ASA-TRPLIDEFAIE-GADGVFRCAVHPPL-AAPISTFRKALLRTG-----MGG- CC1G_02719_Ccin SHPG-RSY-CSLAKDHFLYI-SVHGCHLAFVFEPH-SLNLQ---DYIL-----REKTQNP CC1G_05630_Ccin -HPV-KDH-IHRIHRHFTET-GPNGTHLCLVAPFC-GPSLL---AVADNLSY--RYHRR- CC1G_06188_Ccin VAPG-AKY-CMKLLESFHIE-RETGKHLCLVMELG-GMSVE---DMRPL---IGTNY-S- CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin -SSG-YSK-HPCHFSTWWEE-STRGRHLCYLVEPYCGLSLE---D-VRNGD----PMGR- CC1G_10260_Ccin DHPG-RAH-IVSFLDSFSHQ-GPESSHICIVFEPL-GENLL---ALIERNK-----KKG- CC1G_04899_Ccin THPG-KSH-VIQFLDHFRHK-GPNGTHVCMVFEVL-GENLL---GLIKRHQ-----SKG- AqueK134_Aque -NPG-LKH-VVEMYDSFRIS-GPHGNHMVMVFEVL-GCNLL---RPIIKYN-----YKG- SRPK_b_Smoe ---N-KKC-VVKLLDHFRHT-GPNGQHVCLVFELL-GDNLL---TLIKRHD-----CRG- SRPK_d_Smoe ---N-SKC-VVKLLDHFKHS-GPNGQHVCMVFEFL-GDNLL---TIIKLYN-----YRG- SRPK_a_Smoe ---N-SKC-VVKLLDHFKHS-GPNGQHVCMVFEFL-GDNLL---TIIKLYN-----YRG- SRPK_c_Smoe ---N-KKC-VVKLLDHFRHT-GPNGQHVCLVFELL-GDNLL---TLIKRHN-----CRG- GK042_Glam SFPSIEALPLQAVYDVFRHPAPPNSKHVCLVVEFL-GCSTY---RFLQQYTRRRSSRPA- SRPK2_Hsap -----LPVRCVKSIIRQVLQGLDYLHSKCKIIH---------------------TDI--- SRPK1_Hsap -----LPLPCVKKIIQQVLQGLDYLHTKCRIIH---------------------TDI--- MSSK1_Hsap -----LPVPCVKSIVRQVLHGLDYLHTKCKIIH---------------------TDI--- MSSK1_Mmus -----LPVPCVKSIVRQVLHGLDYLHTKCKIIH---------------------TDI--- SKY1_Scer -----IPLIYVKQISKQLLLGLDYMHRRCGIIH---------------------TDI--- CG8565_Dmel -----MPISNIKQIAQQVLTGLKFLHEECGIIH---------------------TDL--- SRPK_Dmel -----IPLANVKTITRQVLEGLDYLHTCCKIIH---------------------TDI--- SRPK1_Mmus -----LPLPCVKKIIQQVLQGLDYLHTKCRIIH---------------------TDI--- SRPK2_Mmus -----LPVRCVKSIIRQVLQGLDYLHSKCKIIH---------------------TDI--- spk-1_Cele -----LHLEQVRKICRQVLEALGYMHEKCGIIH---------------------TDI--- Sky1_Ddis -----MPITLVKTLMKQTLIALDYIHTKCKIIH---------------------TDL--- 13234_Tthe -----MKYWLVRQIARQCLIGLVYLHDVCGMIH---------------------TDL--- 22244_Tthe -----IPMHLARIIAKQVLIGLDFLHRYCGVIH---------------------TDL--- 3884_Tthe -----VPMHLCRKIAKQVLIGLDFLHRFCDVIH---------------------TDL--- SRPK_Spur ------------------------------------------------------------ CG11489_Dmel -----LAIAQVRNIIRQVLEGLDYLHSKCSIIH---------------------TDI--- CC1G_15433_Ccin -----LPVPLVKALVTYLLEAVDFLHSEAKVVH---------------------TDI--- CC1G_02719_Ccin GLQYLFSLDGIKNIIRQTLLALSYVHAR-QLIH---------------------TDLATD CC1G_05630_Ccin -----IEGRVARRLAKQAALVIERMHSA-GMVHGGSCFDVSVRPILTQCLFRNFTDI--- CC1G_06188_Ccin -----MPTAFVKTIVKQMCKALDYLHEECRVVH---------------------TDL--- CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin -----LPIRTVQFVFNELVEKLSEVHGFADGMH---------------------GSL--- CC1G_10260_Ccin -----VPKALVKIIAKQVLLGLQYLHDECDLVH---------------------TDI--- CC1G_04899_Ccin -----VPMHLVKQIAKQILLGLDYMHRCCGVIH---------------------TDL--- AqueK134_Aque -----LPPSFVKLVTKQVLLGLDYLHTECGIIH---------------------TDI--- SRPK_b_Smoe -----LPLQVVREISAQVLVGLDYLHRELSIIH---------------------TDL--- SRPK_d_Smoe -----LPLPMVKQLSMQILIGLDYLHRQLSIIH---------------------TDL--- SRPK_a_Smoe -----LPLPMVKQLSMQILIGLDYLHRQLSIIH---------------------TDL--- SRPK_c_Smoe -----LPLQVVREISAQVLVGLDYLHRELSIIH---------------------TDL--- GK042_Glam -----IPVPIVKTFARHLLVALGYVHAA-GYVH---------------------TDV--- SRPK2_Hsap -KPENILMCVDDA----YVRRMAAEAT-EWQ-KA-GAP--------PP------------ SRPK1_Hsap -KPENILLSVNEQ----YIRRLAAEAT-EWQ-RS-GAP--------PP------------ MSSK1_Hsap -KPENILLCVGDA----YIRRLAAEAT-EWQ-QA-GAP--------PP------------ MSSK1_Mmus -KPENILLCVGDA----YIRRLAAEAT-EWQ-QS-GAQ--------PP------------ SKY1_Scer -KPENVLMEEN------------------------------------------------- CG8565_Dmel -KPENVLLAKANE----GKL---------------------------------------- SRPK_Dmel -KPENVLLCVSRA----------------------------------------------- SRPK1_Mmus -KPENILLSVNEQ----YIRRLAAEAT-EWQ-RS-GAP--------PP------------ SRPK2_Mmus -KPENILMCVDDA----YVRRMAAEAT-EWQ-KA-GAP--------PP------------ spk-1_Cele -KPENVLITMSRE----EIKIMAQHAV-VAR-KM-NM---------KM------------ Sky1_Ddis -KPENVLLEKSFD----FFTSNDYIWS---E-KY-G--YFK-----NR------------ 13234_Tthe -KPENVMLQLNED----YYHQFIEQVK-KLD-KK-P--MSM-----Y------------- 22244_Tthe -KPENVLLCLTQE----EIKAHGIKID-EV-----P--ILD-----PQEEQ--KQNGHSQ 3884_Tthe -KPENVLLQLTQD----ELKDIIENGQ-MT--KN-Q--LFK-----ERLKVIRKHLGVKE SRPK_Spur ------------------------------------------------------------ CG11489_Dmel -KPENILLVIEK------------------------------------------------ CC1G_15433_Ccin -QESNILLGLNPE----TATADLQKF--EDE-EI-QNP---------------------- CC1G_02719_Ccin VKWSNIFLDQGNQD-DAIIKYLIQNP---------------------S------------ CC1G_05630_Ccin -TTSNMLFRLKES-----VQAMSDDAI-CAQ---LGE---------PV------------ CC1G_06188_Ccin -KPSNILVTFSPKD----TQELIDMTL-KHRP-V-ERY---------------------- CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin -SAENAVFWTWAD-----VKYLKPHL-----------S--------LP------------ CC1G_10260_Ccin -KPENICFTKSTCLEVTSVRQTLEELD-ELT-RS-GIPIQMKGKEKEP------------ CC1G_04899_Ccin -KPENVLICIDDV----ENVILA-ELE-ASS-AA-AST--------PP------------ AqueK134_Aque -KPENILFCVSDE----HVKSLARNRV-S------------------------------- SRPK_b_Smoe -KPENILLTTPLP----KARVFDHK--N-------------------K------------ SRPK_d_Smoe -KPENVLLTLPLD----PSKDPLKSGAPLIL-SK-P-----------A------------ SRPK_a_Smoe -KPENVLLTLPLD----PSKDPLNDGAPRHE-NH-------------------------- SRPK_c_Smoe -KPENILLTMPLP----KARVFDHK--K-------------------K------------ GK042_Glam -KPENLCLKYTLSE----LRTLDTPVF-DCRLRTTAVA--------PS------------ SRPK2_Hsap ---SGSAVST-------------------APQQK------PIGKISKNKKKK--LK-KKQ SRPK1_Hsap ---SGSAVST-------------------APQPK------PADKMSKNKKKK--LK-KKQ MSSK1_Hsap ---SRSIVST-------------------APQEVL-----QTGKLSKNKRKK--MR-RKR MSSK1_Mmus ---SRSTVST-------------------APQEVL------IGKLSKNKRKK--MR-RKR SKY1_Scer ------------------------------------------------------------ CG8565_Dmel ---------------------------------S------PSSKMTKTA----------- SRPK_Dmel ------------------------------------------------------------ SRPK1_Mmus ---SGSAVST-------------------APQPK------PADKMSKNKKKK--LK-KKQ SRPK2_Mmus ---SGSAVST-------------------APQQK------PIGKISKNKKKK--LK-KKQ spk-1_Cele ---SGSAVST-------------------APDHLV---KMAQENMTKNKKKK--MK-KKA Sky1_Ddis ---TS-SSN---------------KQSQQQQQ-PQ------QQ-QSQQN-----I----- 13234_Tthe ------YLKK-------------------QQQ-KQ------SKQTAKKDKKK--EKKKKK 22244_Tthe KENHS-NCNGQ--QKTD-------SQNQSAQN-PN------PQKQEQNDKNN--L-ASKQ 3884_Tthe EEEKP-V---E---EKK-------PQQQQQAK-PD------QKTK-----------KQQE SRPK_Spur ------------------------------------------------------------ CG11489_Dmel ------------------------------------------------------------ CC1G_15433_Ccin -----------------------------SPR-------------------K--IN---- CC1G_02719_Ccin ---KAYPVR---------------F----A------------------------------ CC1G_05630_Ccin ---T-------------------------------------------------------- CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ---EGSTIDG----------------------------------VAKIKAQP--LM---- CC1G_10260_Ccin ---EGLSAGS-------------------SPLKPSSWIEQ-ASSLSSSYKSKGSPFKSSK CC1G_04899_Ccin ---TR-LVGV-------------------PP---S-------KGRGGNQTPRSE------ AqueK134_Aque ---SKSAVCN-------------------APSSLS---KSGGGPMTKNQKKR--LK-KKL SRPK_b_Smoe ---SR-AE----------------ENTDATGKE--------------------------- SRPK_d_Smoe ---AA-AA----------------AATATAGVTSS------SQPLSKSQKKK--LK-KKA SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe ---SR-AE----------------ENTDATGKE-G------GDEFDG------------I GK042_Glam ---TADFVSLSGLEQMEIAAYLQSV----SPQT---TV---------------------- SRPK2_Hsap KRQAE------------------------------------------LLEKRLQEIEELE SRPK1_Hsap KRQAE------------------------------------------LLEKRMQEIEEME MSSK1_Hsap KQQKR------------------------------------------LLEERLRDLQRLE MSSK1_Mmus KQQKR------------------------------------------LLEERLRDLQRLE SKY1_Scer ------------------------------------------------------------ CG8565_Dmel ------------------------------------------------------------ SRPK_Dmel ------------------------------------------------------------ SRPK1_Mmus KRQAE------------------------------------------LLEKRMQEIEEME SRPK2_Mmus KRQAE------------------------------------------LLEKRLQEIEELE spk-1_Cele KKQRE------------------------------------------KLEAELAGLEGLK Sky1_Ddis -NDY-------------------------------------------------------S 13234_Tthe KQEAA------------------------------------------AAAAAVTQATNQT 22244_Tthe EQDQQ------------------------------------------------------N 3884_Tthe DDDND------------------------------------------------------N SRPK_Spur ------------------------------------------------------------ CG11489_Dmel ------------------------------------------------------------ CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin PRSSNRHG---------------------------------------H-----------S CC1G_04899_Ccin ------------------------------------------------------------ AqueK134_Aque KKHQE------------------------------------------LMVKEESMISDVD SRPK_b_Smoe ------------------------------------------------------------ SRPK_d_Smoe AKDKT------------------------------------------------------- SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe ATNKS------------------------------------------------------- GK042_Glam -----RSDHHGSLDDLLDNTSLQVVEGPGNIYSSSSYPLHDALYAADLLFRIVPYPDNLE SRPK2_Hsap REAERKI-----IEE----------------NIT-SAAPSN------------------- SRPK1_Hsap KESGPGQ-----KRP------------------N-KQEESE--------S---------- MSSK1_Hsap AMEAA----------------------------T-QAEDSG--------L---------- MSSK1_Mmus AMEAA----------------------------V-QAEDSS--------S---------- SKY1_Scer ------------------------------------------------------------ CG8565_Dmel ------------------------------------------------------------ SRPK_Dmel ------------------------------------------------------------ SRPK1_Mmus KESGPGQ-----KRP------------------N-KQEESE--------S---------- SRPK2_Mmus REAERKI-----LEE----------------NIT-SAEASG--------E---------- spk-1_Cele MDANGLQ-----EAY------------------N-NAPQNG--------VRMRPPSLLFN Sky1_Ddis DD----------------------------------SDDSHSDYS-DSED---------- 13234_Tthe QDQNSTNNTTTVSEQ----------------TIIETSTNENKELNNQKQE---------- 22244_Tthe ED----------------------------------EDDNDNDND-DEQE---------- 3884_Tthe DD----------------------------------E--DGEDDDGNQKD---------- SRPK_Spur ------------------------------------------------------------ CG11489_Dmel ------------------------------------------------------------ CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin H------------------------------------SQSGA----PWQD---------- CC1G_04899_Ccin ------------------------------------------------------------ AqueK134_Aque AVTTE----------------------------T-DS--VS--------M---------- SRPK_b_Smoe ------------------------------------------------------------ SRPK_d_Smoe ------------------------------------------------------------ SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe ------------------------------------------------------------ GK042_Glam RKFGLLI-----DETSLSKTAIHLDALYSYKNI--------------------------- SRPK2_Hsap -------------------DQDGEYCPEVKLKTTGLEE---------------------- SRPK1_Hsap -PVE---------------RPLKE-NPPNKMTQEKLEE---------------------- MSSK1_Hsap ------------------------------------------------------------ MSSK1_Mmus ------------------------------------------------------------ SKY1_Scer ------------------------------------------------------------ CG8565_Dmel ------------------------------------------------------------ SRPK_Dmel ------------------------------------------------------------ SRPK1_Mmus -PVD---------------RPLTE-NPPNKMTQEKLEE---------------------- SRPK2_Mmus -------------------QQDGEYQPEVTLKAADLED---------------------- spk-1_Cele GPIPQLLQGSSCVNTPSSPRTV-PPPPPSLYPQVGCVC---------------------- Sky1_Ddis ------------------------------------------------------------ 13234_Tthe ------------------------------------------------------------ 22244_Tthe ------------------------------------------------------------ 3884_Tthe ------------------------------------------------------------ SRPK_Spur ------------------------------------------------------------ CG11489_Dmel ------------------------------------------------------------ CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin --------------------PGVA-SPAPAVLVNAVAS---------------------- CC1G_04899_Ccin ------------------------------------------------------------ AqueK134_Aque ------------------------------------------------------------ SRPK_b_Smoe ------------------------------------------------------------ SRPK_d_Smoe ------------------------------------------------------------ SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe ------------------------------------------------------------ GK042_Glam --------------------------PSTEESQEQFWNSLTSICKTVLLKLRGTTSSPFN SRPK2_Hsap -----AAEAETAKDNGEAEDQE--------------EKEDAEKEN--------------- SRPK1_Hsap -----SS--------TIGQDQT--------------L----------------------- MSSK1_Hsap --------------------------------------------R--------------- MSSK1_Mmus --------------------------------------------R--------------- SKY1_Scer ------------------------------------------------------------ CG8565_Dmel ------------------------------------------------------------ SRPK_Dmel ------------------------------------------------------------ SRPK1_Mmus -----SN--------SIGQDQT--------------L----------------------- SRPK2_Mmus -----TTEEETAKDNGEVEDQE--------------EKEDAEKEN--------------- spk-1_Cele -----NQ--------TYHLTQV--------------I----------------------- Sky1_Ddis ------------------------------------------------------------ 13234_Tthe -------------------------------------------------E-IVKNLQENK 22244_Tthe -------------------------------------------------E-GATSTAAS- 3884_Tthe -------------------------------------------------E-GDN-TNLK- SRPK_Spur ------------------------------------------------------------ CG11489_Dmel ------------------------------------------------------------ CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin -------------------PGL---------------T----------TE--PVMEVM-- CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------PPRR--------------VL----------GE--TIRAMR-- CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin -----AD--------GQETSQTAFNSLRTSSSSTSTI-------TIAHSESSSTTATATQ CC1G_04899_Ccin ----------------------------------------------------SVFITGSQ AqueK134_Aque --------------------------------------------T--------------- SRPK_b_Smoe ------------------------------------------------------------ SRPK_d_Smoe ------------------------------------------------------------ SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe ------------------------------------------------------------ GK042_Glam ICIETTQQTKEADVDGDVQPQR--------------IL----------KK--ASTTLR-A SRPK2_Hsap -------------------------IEKD-EDDVDQ-ELANID----------------- SRPK1_Hsap -------------------------MERDTEGGA---AEI-------------------- MSSK1_Hsap -------------------------LDGG-SGST---SSSGCH----------------- MSSK1_Mmus -------------------------LERG-SGST---SSSGCH----------------- SKY1_Scer ------------------------------------------------------------ CG8565_Dmel ------------------------------------------------------------ SRPK_Dmel ------------------------------------------------------------ SRPK1_Mmus -------------------------TERGGEGGA---PEI-------------------- SRPK2_Mmus -------------------------AEKD-EDDVEQ-ELANLD----------------- spk-1_Cele -------------------------LNAN-VGEL---E--NFN----------------- Sky1_Ddis ELKNKGNKKSSNRDR-------DN--------NK-------------------------- 13234_Tthe ETTNNG--KNDEKKQENAI-DLKE--------NQ-------------------------- 22244_Tthe NQNNQGDKKNLTKKQKKNQRRKAA--------HK-------------------------- 3884_Tthe ELEQKLKQPGLTKKQKKNLRKKIS--------MK-------------------------- SRPK_Spur ------------------------------------------------------------ CG11489_Dmel ------------------------------------------------------------ CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin --PSPTGTP-LGPRKTKTMS-IINGVSKL-ISDTSTMLSTGLH----------------- CC1G_04899_Ccin PLPSPSSSFGTSPML-DKWAFGMSRIEGD-D-NS-----NGI------------------ AqueK134_Aque ------------------------------------------------------------ SRPK_b_Smoe ------------------------------------------------------------ SRPK_d_Smoe --------------------------------GK-------------------------- SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe --------------------------------MK-------------------------- GK042_Glam ------------------PLPRINDDEHICVHLLDEATVISIDALSAVPLLKKLAAAELA SRPK2_Hsap ---------------------------PTWIESP-KTNGHI------------------- SRPK1_Hsap -----------------------------------NCNGVI------------------- MSSK1_Hsap ---------------------------PGG------------------------------ MSSK1_Mmus ---------------------------PEG------------------------------ SKY1_Scer ------------------------------------------------------------ CG8565_Dmel ------------------------------------------------------------ SRPK_Dmel ------------------------------------------------------------ SRPK1_Mmus -----------------------------------NCNGVI------------------- SRPK2_Mmus ---------------------------PTWVESP-KANGHI------------------- spk-1_Cele ---------------------------ASQ------------------------------ Sky1_Ddis ------------------------------------------NK---NIKKDDNK--SSV 13234_Tthe ------------------------------------------DQ---NVQKNNNDNAQEK 22244_Tthe ------------------------------------------RK---KQREKEEKN-KQT 3884_Tthe ------------------------------------------KR---KLQEQKNAQ-QQP SRPK_Spur ------------------------------------------------------------ CG11489_Dmel ------------------------------------------------------------ CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin ---------------------------PTSE---------TKPNTNTTNRTPQSG--ETN CC1G_04899_Ccin ----------------------------------------VEKKGLSTVKRAVST--DLV AqueK134_Aque ----------------------------------------I------------------- SRPK_b_Smoe ----------------------------------------------------EIE--AFQ SRPK_d_Smoe ------------------------------------------DK---DMDKA-AE--AM- SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe ------------------------------------------DR---EPGKAEIE--AFQ GK042_Glam LPVTLKKILLAHKRTADEYLQTHSIELPTCMSVPIVLNGYM------------------- SRPK2_Hsap ----------------------------E---------NGPFSLEQ-------------- SRPK1_Hsap ----------------------------EVINYTQNSNNETLRHKE-------------- MSSK1_Hsap ------------------------------------------------------------ MSSK1_Mmus ------------------------------------------------------------ SKY1_Scer ------------------------------------------------------------ CG8565_Dmel ------------------------------------------------------------ SRPK_Dmel ------------------------------------------------------------ SRPK1_Mmus ----------------------------GVVNYPENSNNETLRHKE-------------- SRPK2_Mmus ----------------------------E---------NGPFSLEQ-------------- spk-1_Cele -------------------------------------------V-E-------------- Sky1_Ddis NEINNIS------------KENTDNKDL-------------------------------- 13234_Tthe VETNSTNKQEDSQEKLKQNKEDTK------------------------------------ 22244_Tthe NDQDSN-------------KQQNN---L-------------------------------- 3884_Tthe QEQQST-------------KESTK------------------------------------ SRPK_Spur ------------------------------------------------------------ CG11489_Dmel ------------------------------------------------------------ CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin VTTNHVS------------LLTQ--TAPT------------------------------- CC1G_04899_Ccin AEVNNVS------------LETQA-SYVG------------------------------- AqueK134_Aque ----------------------------D---------NH-------------------- SRPK_b_Smoe DAWKNIG------------LDKSC---LE------------------------------- SRPK_d_Smoe --VATVD------------ATAAA---VE------------------------------- SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe DAWKNIG------------LDKSC---LE------------------------------- GK042_Glam -------------------------------------RGKTLHIQEGLDPYNHVIVNGHQ SRPK2_Hsap -------------Q---------------------------------------------- SRPK1_Hsap -------------D---------------------------------------------- MSSK1_Hsap ------------------------------------------------------------ MSSK1_Mmus ------------------------------------------------------------ SKY1_Scer ------------------------------------------------------------ CG8565_Dmel ------------------------------------------------------------ SRPK_Dmel ------------------------------------------------------------ SRPK1_Mmus -------------D---------------------------------------------- SRPK2_Mmus -------------Q---------------------------------------------- spk-1_Cele -------------D---------------------------------------------- Sky1_Ddis ------------------------------------------------------------ 13234_Tthe ------------------------------------------------------------ 22244_Tthe ------------------------------------------------------------ 3884_Tthe ------------------------------------------------------------ SRPK_Spur ------------------------------------------------------------ CG11489_Dmel ------------------------------------------------------------ CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin -------------R---------------------------------------------- CC1G_04899_Ccin -------------R---------------------------------------------- AqueK134_Aque -------------T---------------------------------------------- SRPK_b_Smoe -------------D---------------------------------------------- SRPK_d_Smoe -------------S---------------------------------------------- SRPK_a_Smoe ------------------------------------------------------------ SRPK_c_Smoe -------------D---------------------------------------------- GK042_Glam FAVARKGSVDCIDDIVVELKHFDPRKAASIAVYKQSRYAFSSYLAMLNCCYDDYYMSDHH SRPK2_Hsap -----------------LDDEDDDE-E------------DCPNPEEYNLDEPNAESDYTY SRPK1_Hsap -----------------LHNAND-----------------------CDVQNLNQESSF-- MSSK1_Hsap ------------------------A-R------------AGPSPASSS-PAPGGGRSLS- MSSK1_Mmus ------------------------T-R------------AGPSPASSS-PVPGGERSLS- SKY1_Scer ------------------------------------------------------------ CG8565_Dmel ------------------------------------------------------------ SRPK_Dmel ------------------------------------------------------------ SRPK1_Mmus -----------------LHNAND-----------------------CDVHTLKQEPSF-- SRPK2_Mmus -----------------LEDEEDDE-D------------DCANPEEYNLDEPNAESDYTY spk-1_Cele -----------------VT-----M-EDTVNENGNRNKVEIRSPDRFDRTTLTPFSD--- Sky1_Ddis ------------NSSEENKK----E-E-------------EQQQ-NKK-EEPTT------ 13234_Tthe ------------------------S-K-------------NKED-DE---KKEK------ 22244_Tthe ------------------------N-D-------------KQAE-GQ---KQQI------ 3884_Tthe ------------------------Q-E-------------NQAE-EN---KPSQ------ SRPK_Spur ------------------------------------------------------------ CG11489_Dmel ------------------------------------------------------------ CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ------------------------------------------------------------ CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin -----------ISAN---------VEP-------------LRTT-TTR-PSPPQ------ CC1G_04899_Ccin -----------MPGA---------PGP-------------SLLT-DTK-PVPI------- AqueK134_Aque -----------------ILPESVEE-EDT-ME-----------TEE-------------- SRPK_b_Smoe ----------------------------------------APSDV--------------- SRPK_d_Smoe -----------GKGG---------SDG-------------APRHENH---KIHA------ SRPK_a_Smoe --------------------------------------------------KIHA------ SRPK_c_Smoe ----------------------------------------APSDV--------------- GK042_Glam HINIGGSFTSNP------------------------------------------------ SRPK2_Hsap SSSYEQFNGELPNGRHKIPESQF----------PEFSTSLFSGSLEPVACG--SVLSEGS SRPK1_Hsap ---LSSQNGD-----SST-SQE-----------TDSCTPITSEVSDTMVCQ--SSSTVGQ MSSK1_Hsap ------------------AGSQ---------------TSGFSGSLFSPASC--SILSG-- MSSK1_Mmus ------------------PSSQ---------------TSGFSGSLFSTASC--SILSG-- SKY1_Scer ------------------------------------------------------------ CG8565_Dmel ------------------------------------------------------------ SRPK_Dmel ------------------------------------------------------------ SRPK1_Mmus ---LNSSNGD-----SSP-SQD-----------TDSCTPTAS---ETMVCQ--SSAE--Q SRPK2_Mmus SSSYEQFNGELPNGQHKT---------------SEFPTPLFSGPLEPVACG--SVISEGS spk-1_Cele ---PESKFGDL-----A------------------------------------------- Sky1_Ddis -----------------------TTTTATATA----------------TTT--------- 13234_Tthe -----------------------ENDS--DYS----------------DCE--------- 22244_Tthe -----------------------EEEV--------------------------------- 3884_Tthe -----------------------QKEM--------------------------------- SRPK_Spur ------------------------------------------------------------ CG11489_Dmel ------------------------------------------------------------ CC1G_15433_Ccin -----------------------EERV--------------------------------- CC1G_02719_Ccin ---------------SQ------------------------------------------- CC1G_05630_Ccin -----------------------EEVI-TASG---------------------------- CC1G_06188_Ccin ---------------SQ------------------------------------------- CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------------------------------QV---------------------------- CC1G_10260_Ccin ---------------------HISQLS--AHMHS-------------EPCP--SLPSHDS CC1G_04899_Ccin -------------------------------------------------------PGA-- AqueK134_Aque ------------------------------------------------------------ SRPK_b_Smoe -----------------------EKLI--CEV---------------------------- SRPK_d_Smoe -----------------------DEAT--GAA----------------DA---------- SRPK_a_Smoe -----------------------DEAT--GAA----------------DA---------- SRPK_c_Smoe -----------------------EKLI--CEV---------------------------- GK042_Glam -------WG-----QSRP-PAR-----------PETCTGEVNGSNETAS-MAASFV--ST SRPK2_Hsap PLT--------EQE-----ES-----SPSHDRSRT----------------V---SASS- SRPK1_Hsap SFS--------EQHISQLQESIRAE-IPCEDEQ----------------------EQEH- MSSK1_Hsap ----------------------------------S----------------S---NQRE- MSSK1_Mmus ----------------------------------S----------------S---NQRE- SKY1_Scer ------------------------------------------------------------ CG8565_Dmel ------------------------------------------------------------ SRPK_Dmel ------------------------------------------------------------ SRPK1_Mmus SLT--------RQDITQLEESIRAD-TPSGDE------------------------QEP- SRPK2_Mmus PLT--------EQE-----ES-----SPSHDRSRT----------------V---SASS- spk-1_Cele --------------------------SPSAE----------------------------- Sky1_Ddis -------TTT------------------------------------------GTEEFKF- 13234_Tthe -------SDS------------------------------------------DRD--EV- 22244_Tthe ----------------------------------------------------KEE--DI- 3884_Tthe ----------------------------------------------------NTK--DL- SRPK_Spur ------------------------------------------------------------ CG11489_Dmel ------------------------------------------------------------ CC1G_15433_Ccin ------------------------------------------------------------ CC1G_02719_Ccin ------------------------------------------------------------ CC1G_05630_Ccin ----------------------------------------------------DP----P- CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ----------------------------------------------------EN----P- CC1G_10260_Ccin VLSSHFPSETSRPNFTTVSTAIAQR-LVFGTSS------------------SPAP--PPP CC1G_04899_Ccin ----------------------------------------------------PSP--EP- AqueK134_Aque -------------------------------TDQ----------------------STT- SRPK_b_Smoe ----------------------------------------------------KK----P- SRPK_d_Smoe ----------------------------------------------------QA----P- SRPK_a_Smoe ----------------------------------------------------QA----P- SRPK_c_Smoe ----------------------------------------------------KK----P- GK042_Glam SYS--HEC--SRTHTRQGSQ-ISSEWSVEHDSSADGEGIPPFDDAICGCIIS---SA--- SRPK2_Hsap -TGDL--PKAKT--RAAD-LLVNPLDP---RNADKIR----------VKIADLGNACWVH SRPK1_Hsap -NGP-LDNKGKS--TAGN-FLVNPLEP---KNAEKLK----------VKIADLGNACWVH MSSK1_Hsap -TGGLLSPSTPF--GASN-LLVNPLEP---QNADKIK----------IKIADLGNACWVH MSSK1_Mmus -TGGLLSPSTPF--GASN-LLVNPLEP---QNADKIK----------IKIADLGNACWVH SKY1_Scer ----------------------------------LIQ----------IKIADLGNACWYD CG8565_Dmel -----------------------------------KR----------RMQADLGNACYFH SRPK_Dmel -----------------------------------------------PKAADLGNACWVD SRPK1_Mmus -NGA-LDSKGKF--SAGN-FLINPLEP---KNAEKLQ----------VKIADLGNACWVH SRPK2_Mmus -TGDL--PKTKT--RAAD-LLVNPLDP---RNADKIR----------VKIADLGNACWVH spk-1_Cele ---YLSSPMSQL--PPGGILPAPPVGPNIGDPYCDID----------VKIADLGNACWVN Sky1_Ddis --VN--GISYKF--KKNN-EL--F------NENHYPR----------AQLVDLGNACWTD 13234_Tthe --SE--EELYTL--KWKN-KI----PI---ALDKSLK----------IKIVDFGNACWIN 22244_Tthe --PE--EIRYKF--DNWN-G----RGD---RLQTNVR----------VKIADLGNACWTH 3884_Tthe --FS--QPDTKL--LDKN-KL--MRGP---QLDENFK----------LKIADLGNACWTF SRPK_Spur -----------------------------------------------IKLADLGNACWTH CG11489_Dmel ------------------------------------Q----------TKSADLGNACYDY CC1G_15433_Ccin -----------T--HVSR-QLVP-------PLYRYGP----------PTLCDFGEARFGE CC1G_02719_Ccin -------PL-P----------L--FEN---PSRNSLT----------LKLGDFGLAAPAL CC1G_05630_Ccin --GP-DAPRELVESIQAS-----RFIE--F-SLVHDS----------ILVSDFGQSFLVD CC1G_06188_Ccin -------PL-P----------LPGFDQ---RNPLTWV----------FKLTDFGSAQWIG CC1G_13566_Ccin ------------------------------------------------------------ CC1G_09673_Ccin ------DP-----------------KS---TDDLPTVMKTWQFVFRGFEYAQVGS----- CC1G_10260_Ccin TPVD-GPVFGSFPISPPP-PF--TSQF---PNPPPIS----------IKIADLGNATPSK CC1G_04899_Ccin -PAD-GAPRSVMSVDQRS-DS--SSAI---DLSEKIT----------VKIADLGNATWVE AqueK134_Aque -NGS--S--------AGS-SCTDS-----FDLLGPVS----------VKIADLGNACWIN SRPK_b_Smoe ------PP-LAS--N---------RKT---SHDVDLR----------CKIVDLGNACWTY SRPK_d_Smoe --GE--APRLAN--KHEK-RL--KVTD---LGELDLR----------CKIVDLGNACWTY SRPK_a_Smoe --GE--APRLAN--KHEK-RL--KVTD---LGELDLR----------CKIVDLGNACWTY SRPK_c_Smoe ------PP-VAS--N---------CKT---SHDVDLR----------CKIVDLGNACWTY GK042_Glam TDTALYRPIMV-----AY-PDTDHLIP---LLPEMFS----------VKLIDLGNSHRLG SRPK2_Hsap K---HFTEDIQTRQYRSIEVLIGA-GYSTPADIWSTACMAFELATG-DYL-FEPH--SG- SRPK1_Hsap K---HFTEDIQTRQYRSLEVLIGS-GYNTPADIWSTACMAFELATG-DYL-FEPH--SG- MSSK1_Hsap K---HFTEDIQTRQYRAVEVLIGA-EYGPPADIWSTACMAFELATG-DYL-FEPH--SG- MSSK1_Mmus K---HFTEDIQTRQYRAVEVLIGA-EYGPPADIWSTACMAFELATG-DYL-FEPH--SG- SKY1_Scer E---HYTNSIQTREYRSPEVLLGA-PWGCGADIWSTACLIFELITG-DFL-FEPD--EG- CG8565_Dmel H---HFTDDIQTKEYRALEVILGA-GYCETADIWSVACLLWELATG-TYL-FDTH--SKR SRPK_Dmel R---HFTEDIQTRQYRSLEVIIGA-GYNTSADIWSTACMVFELATG-DYL-FEPH--SG- SRPK1_Mmus K---HFTEDIQTRQYRSLEVLIGS-GYNTPADIWSTACMAFELATG-DYL-FEPH--SG- SRPK2_Mmus K---HFTEDIQTRQYRSIEVLIGA-GYSTPADIWSTACMAFELATG-DYL-FEPH--SG- spk-1_Cele H---HYTDDIQTRQYRALEVLIGS-GYGPPADIWSTACMAFELATG-DYL-FEPH--QG- Sky1_Ddis K---HFTDDIQTRQYRAPEAIVKA-KWGTPVDIWSAACMAFELATG-DHL-FKPK--SG- 13234_Tthe K---KFTNNIQTREYRAPETILGI-DYQQNTDVFSFACMIYELITN-DYL-FKPK--KR- 22244_Tthe H---HFATEIQTRQYRSPETIIGV-HYDTTADVWSFACMIFEMLTG-DFL-FEPR--KG- 3884_Tthe H---HFATEIQTRQYRSPEVIIGS-KYNTTADIWSLACMLFEMLTG-DFL-FEPR--KG- SRPK_Spur H---HFTEDIQTRQYRALEVLIGA-GYDTAADIWSTACMAFELACG-DYL-FEPH--SG- CG11489_Dmel H---HFTEDIQTRQYRSIEVLLGA-PYNYTADIWSTACLAFELATG-DYL-FDPH--AG- CC1G_15433_Ccin Y---DNMFDIQPYQYRAPEVIFQM-GWDEKVDIWSIGVMLWDLIEN-KNL-FKTT--GGP CC1G_02719_Ccin EAKRRGPFPGTPTDLRAPELVLRS-SWGAPVDIWALGCMFFDLIFS-NRPPFDLR---GP CC1G_05630_Ccin A-MPEDYHPATTIHCTPPEVRFDQ-TISFASDVWMLACTLFEIRAG-FSL-FDS------ CC1G_06188_Ccin K---RSATVVQPIRLRAPEVVLGH-EWNEKIDIWSLGC---------------------- CC1G_13566_Ccin ----------------APETLLSTPSCSPKTDIWMLGVMLFNLLTG-RAL-LTAT---GT CC1G_09673_Ccin ----GLKPHPQHDYASAPETLLSNATCSSQTDIWMLGVMIFKLLTG-RDL---------- CC1G_10260_Ccin K---HFTEDIQTRQYRAPEAIVGRKDWDTRADVWSVACVVFELLTA-EYL-FDPQG-QG- CC1G_04899_Ccin H---HFTDDIQTRQYRCPEVILGA-KWGTSADIWSVACVLFELITGGDYL-FDPA--SG- AqueK134_Aque H---HFTDDIQTRQYRSLEVIIGI-EYGPPADIWSLACMTFELLTG-DFL-FEPH--SG- SRPK_b_Smoe K---QFTADIQTRQYRCPEVLVGS-KYSTPADMWSLACVVFELATG-DVL-FDPH--TG- SRPK_d_Smoe K---QFTNDIQTRQYRSPEVLLGC-KYSTPVDIWSFACLVFELATG-DVL-FDPH--SG- SRPK_a_Smoe K---QFTNDIQTRQYRSPEVLLGC-KYSTPVDIWSFACLVFELATG-DVL-FDPH--SG- SRPK_c_Smoe K---QFTADIQTRQYRCPEVLVGS-KYSTPADMWSLACVVFELATG-DVL-FDPH--TG- GK042_Glam D---TQPPLIQTAPYRAPEVILGL-PFDEKADVWSVGCVIYEFLTG-HIL-FPTVDMSSG * . *:: . SRPK2_Hsap EDYSRDEDHI-AHIIELLG-SIPR--HFA-LSGK-YSRE--FFNR--------------- SRPK1_Hsap EEYTRDEDHI-ALIIELLG-KVPR--KLI-VAGK-YSKE--FFTK--------------- MSSK1_Hsap EDYSRDEDHI-AHIVELLG-DIPP--AFA-LSGR-YSRE--FFNR--------------- MSSK1_Mmus EDYSRDEDHI-AHIVELLG-DIPP--AFA-LSGR-YSRE--FFNR--------------- SKY1_Scer HSYTKDDDHI-AQIIELLG-ELPS--YLL-RNGK-YTRT--FFNS--------------- CG8565_Dmel GKYNLDEVHI-AKIVETCG-RIPW--YLI-RKGK-HSRN--FINS--------------- SRPK_Dmel ESYTRDEDHL-AHIIELLG-PIPR--EIL-LNGT-YAAK--SFTR--------------- SRPK1_Mmus EDYTRDEDHI-ALIIELLG-KVPR--KLI-VAGK-YSKE--FFTK--------------- SRPK2_Mmus EDYSRDEDHI-AHIIELLG-SIPR--HFA-LSGK-YSRE--FFNR--------------- spk-1_Cele DNYSRDEDHL-AHISELLG-AIPP--SIY-KKGK-HWRE--FFHK--------------- Sky1_Ddis KGFEKSDDHL-ALMIELLG-KPPR--FIF-AGGD-ESRV--YFTH--------------- 13234_Tthe DDTTKNDEHL-ALFQESLG-KFNK--QFA-LSGT-KSRE--FFNK--------------- 22244_Tthe PNFSKNDDHI-AQIQELCN-KFTK--KFA-LSGF-KSKK--YFDK--------------- 3884_Tthe PTFSKNDDHL-AQIEELCK-KFPK--SFA-KRGE-KSKK--YFDN--------------- SRPK_Spur ENYSRDEDHI-AHIIELVG-HIPK--HVA-LSGK-YSRD--FFNK--------------- CG11489_Dmel ESYSRDEDHL-AHIVELLG-SIPQ--SVI-FRGK-HGLK--YFTS--------------- CC1G_15433_Ccin DNKDGNNYHV-AHMIALLG-PPPK--DFL-ERTK-ETRLWNWFDK--------------- CC1G_02719_Ccin -PGDLDAIHL-ARMEELLG-PFPP--SMRTLCREDTRDK--YFDD--------------- CC1G_05630_Ccin --FLRSENLVWRQAVEMLG-KLPD--PWW-NQWD-ARKV--WFAESDGEPKPEEVQKEEG CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin -A----AERL-AEMCEVLEVQIPE--SW-LH-DKN------LKDC--------------- CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin ELFTKDDDHM-AQIIELLG-DFPL--DVK-MGGK-YSRE--LFDH--------------- CC1G_04899_Ccin SRYSKDDDHI-AQIMELLG-ELPR--SIA-FSGK-YSSE--FFNR--------------- AqueK134_Aque DTYSRDEDHI-AHICELLG-TIPP--TLA-VSGR-YSRE--FFSH--------------- SRPK_b_Smoe EDYDRDEDHL-ALTMELLG-RMPR--KVA-LGGR-YSHD--YFNR--------------- SRPK_d_Smoe DQFDKDEDHL-ALMIELLG-RMPR--KVS-LGGR-FSRE--FFNR--------------- SRPK_a_Smoe DQFDKDEDHL-ALMIELLG-RMPR--KVS-LGGR-FSRE--FFNR--------------- SRPK_c_Smoe EDYDRDEDHL-ALTMELLG-RMPR--KVA-LGGR-YSHD--YFNR--------------- GK042_Glam -KHISDAQHM-C---DILA-TVPFPGTEYFQASPL-GLS--LLED--------------- SRPK2_Hsap ----------------RG----------------ELRHITKLK---PWSLFDVLV-EKYG SRPK1_Hsap ----------------KG----------------DLKHITKLK---PWGLFEVLV-EKYE MSSK1_Hsap ----------------RG----------------ELRHIHNLK---HWGLYEVLM-EKYE MSSK1_Mmus ----------------RG----------------ELRHIPNLK---HWGLYEVLM-EKYE SKY1_Scer ----------------RG----------------LLRNISKLK---FWPLEDVLT-EKYK CG8565_Dmel ----------------AG----------------KLCNIETLK---PLKLANILI-RWYG SRPK_Dmel ----------------SC----------------ELRNISGLK---PWGLMDVLL-EKYE SRPK1_Mmus ----------------KG----------------DLKHITKLK---PWGLLEVLV-EKYE SRPK2_Mmus ----------------RG----------------ELRHITKLK---PWSLFDVLV-EKYG spk-1_Cele ----------------NG----------------HLLHIHQLK---PWSLYEVLR-QKYE Sky1_Ddis ----------------KG----------------DLRKIPDLS--DQWPLFSVLT-EKYK 13234_Tthe ----------------SG----------------QLIRIKEIQ---DYPISRILI-SEYD 22244_Tthe ----------------QG----------------NLRRIPSLH---YWPLLNVLI-EKYH 3884_Tthe ----------------NG----------------NLRRIPQLQ---YWPLKSVLV-EKYR SRPK_Spur ----------------KG----------------ELRNISKLK---PWSLYHVLT-EKYE CG11489_Dmel ----------------YG----------------SLRNITKLK---PWSLMNVLV-EKYD CC1G_15433_Ccin ----------------DTASWSSPDIVLSIFFSGAWKDEAEI---PAQTLENTI-T---R CC1G_02719_Ccin ----------------DG----------------SLKFKIECSMAASGNLEQQLSPLRQT CC1G_05630_Ccin VLLVARKCTIRDKLELIG----------------KKEEPPRGK---DWPMTE--P-DETV CC1G_06188_Ccin ------------------------------------------------------------ CC1G_13566_Ccin ----------------SP----------------EKRGLQ---------ILEGH-L-EAV CC1G_09673_Ccin ------------------------------------------------------------ CC1G_10260_Ccin ----------------TG----------------ALRYIRTLK---PWPLKRVMI-EKYL CC1G_04899_Ccin ----------------KG----------------ELRHINKLR---YWPLDSVLH-DKYL AqueK134_Aque ----------------SG----------------KLKRIHHLR---PWSLHDVLV-DKYH SRPK_b_Smoe ----------------HG----------------DLRHIRKLR---FWPLKRVLV-EKYD SRPK_d_Smoe ----------------QG----------------DLRHIKKLR---YWPLDKVLH-DKYS SRPK_a_Smoe ----------------QG----------------DLRHIKKLR---YWPLDKVLH-DKYS SRPK_c_Smoe ----------------HG----------------DLRHIRKLR---FWPLKRVLV-EKYD GK042_Glam ----------------EC----------------TKKYLDATA---HFSLQL-RL-EQTG SRPK2_Hsap WPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWL SRPK1_Hsap WSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWL MSSK1_Hsap WPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPWL MSSK1_Mmus WPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPWL SKY1_Scer FSKDEAKEISDFLSPMLQLDPRKRADAGGLVNHPWL CG8565_Dmel WRTRQSTEFVNFLMPMLQTNPLSRISASKALESHYL SRPK_Dmel WSQKDAASFASFLTPMLEFDPNKRATAAECLQHPWL SRPK1_Mmus WPQEEAAGFTDFLLPMLELMPEKRATAAECLRHPWL SRPK2_Mmus WPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWL spk-1_Cele WSHEDAQQFESFLRPMLDFDQEKRSTAKIALKHPFL Sky1_Ddis FSIQEAKDFEAFLLPMLNYLPEKRATAKDCLNHTWL 13234_Tthe WDTKEALDIEDFLLPMLHYNPSKRIQAREALQHPWL 22244_Tthe FKEEEAKLFDEFMQVMLKTNPLDRASAHECLQTKWI 3884_Tthe LKEKEAKAFEDFMMPMLHCMPEKRATAEQMLNHPWL SRPK_Spur WPKEDAEEFASFLYPMLEFDPTKRATAKESLSHPWL CG11489_Dmel WDPVEAKKFSDFLLPMLEYNPVIRASAAECLQHPWL CC1G_15433_Ccin MEGEEKALFINFARRILKWKPEERCSAKELSEDP-W CC1G_02719_Ccin FSDHDVDELIRFMRRCLTIDPASRPTADELLQDPWL CC1G_05630_Ccin MEEEEIKLLQDLLQKMLRYRPEERISMAEVIQHP-W CC1G_06188_Ccin -----------------------------------L CC1G_13566_Ccin LPQDQAKSVSSLLKSCLRLDPATRISAADLVAHEWI CC1G_09673_Ccin -----------------------------------F CC1G_10260_Ccin YSEEDSDALCAFLEPMLKADMRERAHARDMLDHPWL CC1G_04899_Ccin FPKHEADALAAFLLPMLRLHPDRRAKASELIHHNWL AqueK134_Aque WCDDEAKLLASFLLPMLNYNQKERATAKECLDHPWL SRPK_b_Smoe FSEVDAQDLSSFLCPILEFVPEKRLTAAQALQHSWL SRPK_d_Smoe FPAQDAQELAEFLCPLLDFVADKRPTAGQCLLHPWV SRPK_a_Smoe FPAQDAQELAEFLCPLLDFVADKRPTAGQCLLHPWV SRPK_c_Smoe FSEVDAQDLSSFLCPILEFVPEKRLTAAQALQHSWL GK042_Glam FTREEACLAGSFLEQLLTVDHKKRPSATQMLEHPWL