CLUSTAL W (1.83) multiple sequence alignment MEKK15_Hsap_MEKK15 WTK---GE-ILGKGAYGTVYCGLT-S-QGQLIAVKQVALDTSN--------K-------- MAP3K7_Hsap_ASK HDANGERV-VLGKGTYGIVYAGRDLS-NQVRIAIKEIPERD------------------- MAP3K6_Hsap_ASK YTETGERL-VLGKGTYGVVYAGRDRH-TRVRIAIKEIPERD------------------- MAP3K5_Hsap_ASK YDENGDRV-VLGKGTYGIVYAGRDLS-NQVRIAIKEIPERD------------------- MAP3K4_Hsap_MEKK4 WQR---GN-KIGEGQYGKVYTCISVD-TGELMAMKEIRFQPND----------------- MAP3K3_Hsap_MEKK2 WRR---GK-LLGQGAFGRVYLCYDVD-TGRELASKQVQFDPDS--------P-------- MAP3K2_Hsap_MEKK2 WRL---GK-LLGQGAFGRVYLCYDVD-TGRELAVKQVQFDPDS--------P-------- MAP3K1_Hsap_MEKK1 WLK---GQ-QIGLGAFSSCYQAQDVG-TGTLMAVKQVTYVRNT--------S-------- MEKK15_Mmus_MEKK15 WTK---GE-ILGRGAYGTVYCGLT-S-LGQLIAVKQVALDTSD--------K-------- MAP3K7_Mmus_ASK HDANGERV-VLGKGSYGIVYAGRDLS-NQVRIAIKEIPERD------------------- MAP3K6_Mmus_ASK YSETGERL-VLGRGTYGVVYAGRDRH-TRVRIAIKEIPERD------------------- MAP3K5_Mmus_ASK YDENGDRV-VLGKGTYGIVYAGRDLS-NQVRIAIKEIPERD------------------- MAP3K4_Mmus_MEKK4 WQR---GN-KIGEGQYGKVYTCISVD-TGELMAMKEIRFQPND----------------- MAP3K3_Mmus_MEKK2 WRR---GK-LLGQGAFGRVYLCYDVD-TGRELASKQVQFDPDS--------P-------- MAP3K2_Mmus_MEKK2 WRL---GK-LLGQGAFGRVYLCYDVD-TGRELAVKQVQFNPES--------P-------- MAP3K1_Mmus_MEKK1 WLK---GQ-QIGLGAFSSCYQAQDVG-TGTLMAVKQVTYVRNT--------S-------- nsy-1_Cele_ASK SNE---RV-VLGKGTYGTVYAARDMD-TQRQIVVKEIEVKY------------------- B0414.7_Cele_MEKK4 WAL---LD-HIASGSFGSVHRAMDID-SHRVIAAKVMRIQRE------------------ STE11_Scer_STE11-Unclassified WLK---GA-CIGSGSFGSVYLGMNAH-TGELMAVKQVEIKNNN--------IGVPTDNNK SSK22_Scer_STE11-Unclassified WQK---RS-FIGGGTFGQVYSAINLE-NGEILAVKEIKIHDTT--------T-------- SSK2_Scer_STE11-Unclassified WQK---RN-FIGGGTFGRVYSAVDLD-NGEILAVKEINIQDSK--------S-------- CDC15_Scer_CDC15 YHL---KQ-VIGRGSYGVVYKAINKH-TDQVVAIKEVVYEND------------------ BCK1_Scer_STE11-Unclassified WMK---GE-MIGKGSFGAVYLCLNVT-TGEMMAVKQVEVPKYS--------SQ------- Pk92B_Dmel_ASK QNR---KM-VLGKGTYGTVYAARDKQ-TQVRIAIKEVPEKN------------------- Mekk1_Dmel_MEKK4 WHR---GI-KIGQGRFGKVYTAVNNN-TGELMAMKEIAIQPGE----------------- DDB0229877_Ddis_CDC15 YQI---GE-AVGKGAFGKVFKALNAE-TGDFCAIKQIEKTII------------------ DDB0229896_Ddis_CDC15 YNL---GV-VIGKGGFGTVYQGLDIE-DGDFVAIKQINLTKI------------------ DDB0229915_Ddis_CDC15 YTL---GE-KIGRGAFGQVFKGLNGK-TGEFVAIKQIDSNKI------------------ DDB0229971_Ddis_CDC15 FVI---SDIAIGKGAFATVFKGLNTL-SGDFVAIKRFEKSKI------------------ DDB0231212_Ddis_CDC15 YLL---ID-IIGKGGFGVVYKGLHKT-KGYFSAIKKIKIMKKK--------K-------- MEKKalpha_Ddis_STE11-Unclassified WQK---GQ-ILGRGGYGSVYLGLNKD-TGELFAVKQLEIVDIN--------S-------- 11359_Tthe_STE11-Unclassified FKK---GH-IIDRGSYGEVYQCLEVN-TGQLYAIKTIRKNKDK--------A-------- 15684_Tthe_STE11-Unclassified ------DK-ILGKGTFGTVVLGHNKN-TGEIVAVKLIETQYDR----------------- 18758_Tthe_STE11-Unclassified WKS---GD-FIGAGSFGQVFTAMNCN-TGEIFVVKKIMVHGQS--------K-------- 23105_Tthe_STE11-Unclassified VEL---RE-LLGEGAYGKVYKGFIKK-TGKFIAVKQLKLGLKD--------N-------- 29763_Tthe_STE11-Unclassified WQS---GE-VLGTGSFGQVILGMNID-TGEFMAVKQVHIGGYN--------Q-------- 4322_Tthe_CDC15 YKV---GV-KLGQGASGTVYKGEHIE-TGQVVAIKLVSTVNI------------------ 6622_Tthe_STE11-Unclassified AQV---GE-LIGQGAYGRVYKGFVKS-TGKFIAIKEMKEEMML--------G-------- 7147_Tthe_STE11-Unclassified YKK---CE-LIDKGAYGKVYKGIDTI-TNQVVAIKYIEITGTF--------E-------- MEKK1_Spur_MEKK1 WTK---GA-ILGTGAFSSCYMARDVK-TGTLMAVKQISFCRNN--------A-------- MEKK2_Spur_MEKK2 WQR---GK-LLGQGAFGVVYVCYDAD-TGRELAVKQVPTENSN--------T-------- MEKK4_Spur_MEKK4 WQR---GF-KIGEGQFGTVYSCINMN-TGETLAVKEMRFQRND----------------- ASK_Spur_ASK ------------------------------------------------------------ MEKK15_Spur_MEKK15 WKK---GN-LLGKGAFGTVYCGLT-N-TGQLLAVKQVELSEID--------K-------- CC1G_00852_Ccin_CDC15 --L---GN-CIGRGQFGSVYRALNLN-TGQMVAVKRIRLEGLK----------------- CC1G_05008_Ccin_CDC15 YQL---GD-SLGKGAFGQVYRALNWE-TGETVAVKEIQLSNI------------------ CC1G_12014_Ccin_STE11-Unclassified WIK---GA-LIGAGSFGKVYLGMDAS-NGLLMAVKQVELPQGD--------GP------- CC1G_10524_Ccin_STE11-Unclassified WIR---GE-LLGKGSYGRVYLALNAT-TGEVMAVKQVELPKTP--------SD------- CC1G_13687_Ccin_STE11-Unclassified WQQ---GR-FIGAGAFGSVYLAMNLD-SGSLMAVKEIKFQELS--------G-------- CC1G_10513_Ccin_STE11-Unclassified WVR---GE-LIGKGTYGRVYLALNAT-TGEMIAVKQVELPQTP--------SD------- AqueK224_Aque_ASK LHE---PV-VLGKGSFGIVYSAIDLV-TKKKMAIKEIPERT------------------- AqueK225_Aque_MEKK1 ----------------------------------KQIRLEQES--------L-------- AqueK226_Aque_MEKK15 WKK---GK-LLGRGAYGKVYEGLL-D-TARLIAVKEVELEVED--------N-------- AqueK227_Aque_MEKK2 WSK---GR-LLGTGAFGQVFLCTDLD-TQMDMAVKVVDIDHIENIKPSLDSL-------- AqueK228_Aque_MEKK4 WRR---GR-KLGEGQFGVVYECINLD-RGEVQAVKMISLKEKS----------------- MEKK2-p1_a_Smoe_MEKK2-plant1 WRK---GE-LIGVGAYGRVYMGMNLD-SGELIAVKQVLIAASN--------F-------- MEKK2-p1_b_Smoe_MEKK2-plant1 WRK---GE-LIGVGAYGRVYMGMNLD-SGELIAVKQVLIAASN--------F-------- STE11-p2_b-2_Smoe_MEKK2-plant2 WTR---GE-LLGEGAYGKVFAGLNQT-TGELMAVKQLKIEPTD--------G-------- STE11-p2_a_Smoe_MEKK2-plant2 ---------------FSQVFSGLNQS-TGELMAVKQLKIDPGE--------G-------- STE11-p2_b-1_Smoe_MEKK2-plant2 ------------------VFAGLNQT-TGELMAVKQLKIEPTD--------G-------- STE11-p2_h_Smoe_MEKK2-plant2 -------------------------------MAVKQLKIDPGE--------G-------- NPK1-2_Smoe_NPK1 YII---GD-EIGKGAYGRVYKGLDLE-NGDFVAIKQVSLENI------------------ NPK1-1_Smoe_NPK1 YII---GD-EIGKGAYGRVYKGLDLE-NGDFVAIKQVSLENI------------------ STE11-p2_e-2_Smoe_STE11-plant1 WKK---LE-LLGSGSFGSVYRAVG-SD-GNYFAVKEVPLSNAN----------------- STE11-p2_j_Smoe_STE11-plant1 ------------------------------------------------------------ STE11-p2_e-1_Smoe_STE11-plant1 WKK---LE-LLGSGSFGSVYRAVG-SD-GNYFAVKEVPLSNAN----------------- STE11-p2_g_Smoe_STE11-plant2 -------------------------N-IGRMCAMKEVRIIGDN--------D-------- STE11-p2_c_Smoe_STE11-plant2 WKK---GA-LIGSGSFGNVYVGFDSY-IGRFCAIKEAMISCSD--------Y-------- STE11-p2_f_Smoe_STE11-plant2 WQK---GN-LLGVGSFGRVYKGFS-D-SGTFCAMKEVLVVDD---------P-------- STE11-p2_d-1_Smoe_STE11-plant2 WQK---GK-LIGRGSFGNVYVGFDSENVGRMCAMKEVPLLSDD--------S-------- STE11-p2_d-2_Smoe_STE11-plant2 -------------------------------CAMKEVPLLSDD--------S-------- STE11-p3-1_Smoe_STE11-plant3 WVC---GG-LIGAGAFGSVNLAVDNE-TGDLFAVKSTECSGGR----------------- STE11-p3-2_Smoe_STE11-plant3 WVC---GG-LIGAGAFGSVNLAVDNE-TGDLFAVKSTECSGGR----------------- GK076_Glam_CDC15 -----------------RTYKALCNI-DGIVPAIKIYRLSDVS----------------- GK077_Glam_CDC15 YTL---HC-LIGKGAFAKVWKAADEV-TGGFVALKQLEPKGKK--------K-------- GK078_Glam_STE11-Unclassified YSL---GR-IIGHGSFGQVYLALEHL-TGKLLAVKEMVVKNCS----------------- MEKK15_Hsap_MEKK15 ------------------------------L----AAEKEYRKLQEEVDL-LKALKH-VN MAP3K7_Hsap_ASK -------------------------------------SRYSQPLHEEIAL-HKYLKH-RN MAP3K6_Hsap_ASK -------------------------------------SRFSQPLHEEIAL-HRRLRH-KN MAP3K5_Hsap_ASK -------------------------------------SRYSQPLHEEIAL-HKHLKH-KN MAP3K4_Hsap_MEKK4 -------------------------------------HKTIKETADELKI-FEGIKH-PN MAP3K3_Hsap_MEKK2 -----------------------------------ETSKEVSALECEIQL-LKNLQH-ER MAP3K2_Hsap_MEKK2 -----------------------------------ETSKEVNALECEIQL-LKNLLH-ER MAP3K1_Hsap_MEKK1 ------------------------------S----EQEEVVEALREEIRM-MSHLNH-PN MEKK15_Mmus_MEKK15 ------------------------------L----ATEKEYRKLQEEVDL-LKALKH-VN MAP3K7_Mmus_ASK -------------------------------------IRYSQPLHEEIAL-HKYLKH-RN MAP3K6_Mmus_ASK -------------------------------------SRFSQPLHEEIAL-HKRLRH-KN MAP3K5_Mmus_ASK -------------------------------------SRYSQPLHEEIAL-HKHLKH-KN MAP3K4_Mmus_MEKK4 -------------------------------------HKTIKETADELKI-FEGIKH-PN MAP3K3_Mmus_MEKK2 -----------------------------------ETSKEVSALECEIQL-LKNLQH-ER MAP3K2_Mmus_MEKK2 -----------------------------------ETSKEVNALECEIQL-LKNLLH-ER MAP3K1_Mmus_MEKK1 ------------------------------S----EQEEVVEALREEIRM-MGHLNH-PN nsy-1_Cele_ASK -------------------------------------DEEVQPLMEEISL-HSTLCH-AN B0414.7_Cele_MEKK4 ---------------------------------------NHKAIESEINI-FRQLIH-EN STE11_Scer_STE11-Unclassified QANSDENNEQEEQQEKIEDVGAVSHPKTNQN----IHRKMVDALQHEMNL-LKELHH-EN SSK22_Scer_STE11-Unclassified ------------------------------------MKKIFPLIKEEMTV-LEMLNH-PN SSK2_Scer_STE11-Unclassified ------------------------------------MQKIFPLIKEEMSV-LEILNH-PN CDC15_Scer_CDC15 --------------------------------------EELNDIMAEISL-LKNLNH-NN BCK1_Scer_STE11-Unclassified ---------N--------------------E----AILSTVEALRSEVST-LKDLDH-LN Pk92B_Dmel_ASK -------------------------------------SQDVQPLHEEIKL-HSQLRH-RN Mekk1_Dmel_MEKK4 -------------------------------------TRALKNVAEELKI-LEGIKH-KN DDB0229877_Ddis_CDC15 ------------------------------------SEKQLPSIIQEIKL-LQTLQH-PN DDB0229896_Ddis_CDC15 ------------------------------------PKDQLQGIMNEIDL-LKNLNH-AN DDB0229915_Ddis_CDC15 ------------------------------------DESSLQSVKGEVEI-LHKLRH-NN DDB0229971_Ddis_CDC15 ------------------------------------SNEQHSSVSTEFDI-LQRLNH-EN DDB0231212_Ddis_CDC15 ------------------------------L-----QSESQISLMAEINL-LKVLSH-HN MEKKalpha_Ddis_STE11-Unclassified -----------------------------DP----KLKNMILSFSKEIEV-MRSLRH-DN 11359_Tthe_STE11-Unclassified -----------------------------------VLEKEVQSLAKEIKE-YKKLSH-KN 15684_Tthe_STE11-Unclassified -------------------------------------KQKYKSIIDEVKI-LKQMRH-KN 18758_Tthe_STE11-Unclassified -----------------------------------LDKEFLDEQEKELRI-MQTLSH-KH 23105_Tthe_STE11-Unclassified ------------------------------N----KLQEKLEQYLQEIAL-LNHLEH-PN 29763_Tthe_STE11-Unclassified ------------------------------K----DRQEKIQQIQSEIEA-LRNFSD-KN 4322_Tthe_CDC15 ------------------------------------KKENIKSIKKEMHL-LKKLKH-EN 6622_Tthe_STE11-Unclassified ------------------------------E----DAHSLLESICKEIQL-LKQLSH-KN 7147_Tthe_STE11-Unclassified -----------------------------------EVKKEINSLKKEIVL-LKKLNH-QN MEKK1_Spur_MEKK1 ------------------------------G----DQEDTMEEIKKEIKL-MATFDH-PH MEKK2_Spur_MEKK2 -----------------------------------DARKEVQSLKQEIEL-LRNLQH-PR MEKK4_Spur_MEKK4 -------------------------------------HQVIRDIADEIKN-LEGIRH-PN ASK_Spur_ASK ------------------------------------------------------------ MEKK15_Spur_MEKK15 ------------------------------E----KAKQQYLKLQEEVQL-LKTLRH-KN CC1G_00852_Ccin_CDC15 -------------------------------------EEEVTQLMREVDL-VKSLSH-PS CC1G_05008_Ccin_CDC15 ------------------------------------PKGELPEIMSEIDL-LKNLNH-EN CC1G_12014_Ccin_STE11-Unclassified ----------------------------SQE----RKKSMLSALEREIEL-LKVLQH-EN CC1G_10524_Ccin_STE11-Unclassified ---------K------------------MKP----QQLDVMKALKFEGDT-LKDLDH-PN CC1G_13687_Ccin_STE11-Unclassified ------------------------------------LPNLYAQIKDELSV-MEMLHH-PN CC1G_10513_Ccin_STE11-Unclassified ---------R------------------NDS----RQNTVVQALKLESET-LKDLDH-PH AqueK224_Aque_ASK -------------------------------------EGQFQSLEEEIQL-HRHLQH-EN AqueK225_Aque_MEKK1 ------------------------------T----AVNETL--ISLRLSS-SSKDH-PPN AqueK226_Aque_MEKK15 ------------------------------E----KALVQFKKIQLEVDI-LRSLSH-KN AqueK227_Aque_MEKK2 -----------------------------------KMSKEVRSFETEVQL-LKNIHH-ER AqueK228_Aque_MEKK4 -------------------------------------HNTVRDILSEVGV-FQSINH-KN MEKK2-p1_a_Smoe_MEKK2-plant1 ------------------------------AKGKAQLSAHIRELEEEVKL-LQNLSH-PN MEKK2-p1_b_Smoe_MEKK2-plant1 ------------------------------AKGKAQLSAHIRELEEEVKL-LQNLSH-PN STE11-p2_b-2_Smoe_MEKK2-plant2 ------------------------------Q----SRAVYLASLEREIDL-YKQLRH-RH STE11-p2_a_Smoe_MEKK2-plant2 ------------------------------Q----EKSFYLAALEREINL-YRKLRH-KH STE11-p2_b-1_Smoe_MEKK2-plant2 ------------------------------Q----SRAVYLASLEREIDL-YKQLRH-RH STE11-p2_h_Smoe_MEKK2-plant2 ------------------------------Q----EKSFYLAALEREINL-YRKLRH-KH NPK1-2_Smoe_NPK1 ------------------------------------PPEDLASIMQEIDL-LKNLNH-KN NPK1-1_Smoe_NPK1 ------------------------------------PPEDLASIMQEIDL-LKNLNH-KN STE11-p2_e-2_Smoe_STE11-plant1 -------------------------------------DQSGLQLQQEVNL-LGNLRH-EN STE11-p2_j_Smoe_STE11-plant1 ------------------------------------------------------------ STE11-p2_e-1_Smoe_STE11-plant1 -------------------------------------DQSGLQLQQEVNL-LGHLRH-EN STE11-p2_g_Smoe_STE11-plant2 -----------------------------------QSKESAKQLGQEITL-LSRLRH-QN STE11-p2_c_Smoe_STE11-plant2 -----------------------------------RSQECCKQLRQEIAM-LSRLRH-PN STE11-p2_f_Smoe_STE11-plant2 -----------------------------------KSIESVKQLMQEINM-LSSLRH-PN STE11-p2_d-1_Smoe_STE11-plant2 -----------------------------------KSKESVKQLSQEIAT-LSRLRH-TN STE11-p2_d-2_Smoe_STE11-plant2 -----------------------------------KSKESVKQLSQEIAT-LSRLRH-TN STE11-p3-1_Smoe_STE11-plant3 -----------------------------------SSDGALLALENELSI-LQSLQSSPR STE11-p3-2_Smoe_STE11-plant3 -----------------------------------SSDGALLALENELSI-LQSLQSSPR GK076_Glam_CDC15 -------------------------------------KSSVDFDQKEIDTAARSLLQ-PN GK077_Glam_CDC15 ------------------------------A----VDQGFIKEVMSEINL-LSKLNH-SN GK078_Glam_STE11-Unclassified -------------------------------------REVLEAIDAETRI-LINLRH-PN MEKK15_Hsap_MEKK15 IVAYLGTCLQ------ENTVSIFMEFVPGGSIS----------------SIIN--RF-GP MAP3K7_Hsap_ASK IVQYLGSVS------ENGYIKIFMEQVPGGSLS----------------ALLR-SKW-GP MAP3K6_Hsap_ASK IVRYLGSAS------QGGYLKIFMEEVPGGSLS----------------SLLR-SVW-GP MAP3K5_Hsap_ASK IVQYLGSFS------ENGFIKIFMEQVPGGSLS----------------ALLR-SKW-GP MAP3K4_Hsap_MEKK4 LVRYFGVELH------REEMYIFMEYCDEGTLE----------------EVS---RL-G- MAP3K3_Hsap_MEKK2 IVQYYGCLRD----RAEKTLTIFMEYMPGGSVK----------------DQLK--AY-GA MAP3K2_Hsap_MEKK2 IVQYYGCLRD----PQEKTLSIFMEYMPGGSIK----------------DQLK--AY-GA MAP3K1_Hsap_MEKK1 IIRMLGATCE----K--SNYNLFIEWMAGGSVA----------------HLLS--KY-GA MEKK15_Mmus_MEKK15 IVAYLGTCLE------ENTLSIFMEFVPGGSIS----------------SIIN--RF-GP MAP3K7_Mmus_ASK IVQYLGSVS------ENGYIKIFMEQVPGGSLS----------------ALLR-SKW-GP MAP3K6_Mmus_ASK IVRYLGSAS------QGGYLKIFMEEVPGGSLS----------------SLLR-SVW-GP MAP3K5_Mmus_ASK IVQYLGSFS------ENGFIKIFMEQVPGGSLS----------------ALLR-SKW-GP MAP3K4_Mmus_MEKK4 LVRYFGVELH------REEMYIFMEYCDEGTLE----------------EVS---RL-G- MAP3K3_Mmus_MEKK2 IVQYYGCLRD----RAEKILTIFMEYMPGGSVK----------------DQLK--AY-GA MAP3K2_Mmus_MEKK2 IVQYYGCLRD----PQEKTLSIFMEYMPGGSIK----------------DQLK--AY-GA MAP3K1_Mmus_MEKK1 IIRMLGATCE----K--SNYNLFIEWMAGGSVA----------------HLLS--KY-GA nsy-1_Cele_ASK IVQYLGCDLVG-KDGSNDHFLIFMEHVPGGSLS----------------SLLR-SKW-GP B0414.7_Cele_MEKK4 LVKYYGVQVE------DSDVIIFMEYCSQGTLE----------------RIC----H-GK STE11_Scer_STE11-Unclassified IVTYYGASQE------GGNLNIFLEYVPGGSVS----------------SMLN--NY-GP SSK22_Scer_STE11-Unclassified IVQYYGVEVH------RDKVNIFMEYCEGGSLA----------------SLLD--HG-RI SSK2_Scer_STE11-Unclassified IVSYYGVEVH------RDKVNIFMEYCEGGSLA----------------ALLE--HG-RI CDC15_Scer_CDC15 IVKYHGFIRK------SYELYILLEYCANGSLR----------------RLIS--RSSTG BCK1_Scer_STE11-Unclassified IVQYLGFENK------NNIYSLFLEYVAGGSVG----------------SLIR--MY-GR Pk92B_Dmel_ASK IVRYLGSCS------ENGFFKIFMEQVPGGSLS----------------DLLE-TKW-GP Mekk1_Dmel_MEKK4 LVRYYGIEVH------REELLIFMELCSEGTLE----------------SLVE--LT-GN DDB0229877_Ddis_CDC15 IVKFIESYET------SRYLYFALEFIEGGSLA----------------KIAK--RY-GC DDB0229896_Ddis_CDC15 IVKYIKYVKT------KDNLYIVLEYVENGSLS----------------GIIK--KF-GK DDB0229915_Ddis_CDC15 IVKVLGVVEV------QAQLNFILEYVENGSLR----------------DVIE--KF-GP DDB0229971_Ddis_CDC15 IVRILGREEN------ENYIYIFLEYMENGSLS----------------TILN--NF-GT DDB0231212_Ddis_CDC15 IVRYYEHIPS------SSHSYIVMEFIENGSLE----------------KIIK--RH-GL MEKKalpha_Ddis_STE11-Unclassified IVRYLGTSLD------QSFLSVFLEYIPGGSIS----------------SLLG--KF-GA 11359_Tthe_STE11-Unclassified IVKYIDTELD----EDEKGINIILEYVSGGSIR----------------QMLD--KF-GK 15684_Tthe_STE11-Unclassified IVRYYGIQEH----KAKDHIGIVCEYVSGGSLW----------------RLIQ--KF-GK 18758_Tthe_STE11-Unclassified IIQYKGHERQ------QDCLCIFLEYMSEGNID----------------QMLK--KF-GP 23105_Tthe_STE11-Unclassified IVKYYDCKHE----E--DNILIYMEQMPGGSLS----------------SMLE--KF-GR 29763_Tthe_STE11-Unclassified IVRYIGIKKS----E--TSINIFLEYVPGGSIS----------------SLLY--RY-GK 4322_Tthe_CDC15 IVTYIDFIQT------ENHYAIILEYIESGSLY----------------GIIK--KF-GP 6622_Tthe_STE11-Unclassified IVNYIGSKKQ----E--GSVYIYMEYMPGGSIS----------------EMLK--KY-GG 7147_Tthe_STE11-Unclassified IVKYYDFEIS----DDKSGVDIILEYVPNGSLR----------------MALN--KQ-RC MEKK1_Spur_MEKK1 IVRLMGATQH----D--AHFNVFVEWMPGGAVS----------------TLLK--DF-GA MEKK2_Spur_MEKK2 IVQYFGCLEE------NGTLSIFMEFMSGGSVK----------------DELR--LY-GP MEKK4_Spur_MEKK4 LVRYYGVEIH------RFKMYHFLQYLTRTTLK----------------FVC---HL-G- ASK_Spur_ASK -----------------------MEQVPGGSLS----------------ALLR-SKW-GP MEKK15_Spur_MEKK15 IVGFLGVSLE------DNVVNIFMQFIPGGSIA----------------SLLA--RF-GS CC1G_00852_Ccin_CDC15 IVKYEGMARD------EDTLSIVLEYAENGSLG----------------QTLK--AF-GK CC1G_05008_Ccin_CDC15 IVKYKGFVKT------REFLYIILEFCENGSLH----------------NIIK--KF-GK CC1G_12014_Ccin_STE11-Unclassified IVQYLYSSSD------DEYLNIFLEYVPGGSVA----------------TLLS--NY-GA CC1G_10524_Ccin_STE11-Unclassified IVSYLGFEES------QDYLSIFLEYVPGGTVG----------------SLLV--KN-GR CC1G_13687_Ccin_STE11-Unclassified VVEYYGIEVH------RDKVYIFEEYCQGGSLA----------------ALLE--HG-RI CC1G_10513_Ccin_STE11-Unclassified IVQYLGFEET------PANLSIFLEYVPGGSIG----------------SCLH--KH-GK AqueK224_Aque_ASK IVQYFGAYS------DGGIFRIFMEQVPGGSLS----------------HLLK-FTW-GP AqueK225_Aque_MEKK1 IVEFYGASLLP--LQVETKLQLFLELMPC-CLQ----------------SYLY--NG-GP AqueK226_Aque_MEKK15 IVQYLGTSIN------ETIVYIFMEYITGGSLQ----------------SILK--RF-GS AqueK227_Aque_MEKK2 VVGYYGTERR------EGKLFIFMEYLAGGSIY----------------QHLK--NT-GA AqueK228_Aque_MEKK4 IVHFHGVEIH------DTDLYLFMEYCNQGTLW----------------GAAK---Q-G- MEKK2-p1_a_Smoe_MEKK2-plant1 IVRYLGTARE----E--EALNIFLEFVPGGSIS----------------SLLG--KF-GS MEKK2-p1_b_Smoe_MEKK2-plant1 IVRYLGTARE----E--EALNIFLEFVPGGSIS----------------SLLG--KF-GS STE11-p2_b-2_Smoe_MEKK2-plant2 IVGYIAMEQD----EANNLLYIFLEYVSGGSIQ----------------SMLE--RF-GR STE11-p2_a_Smoe_MEKK2-plant2 IVGYINMEQD----EQSGSLYIFLEYVSGGSIQRQAAYFNFSYHLLLLNSMLE--RF-GR STE11-p2_b-1_Smoe_MEKK2-plant2 IVGYIAMEQD----EANNLLYIFLEYVSGGSIQ----------------SMLE--RF-GR STE11-p2_h_Smoe_MEKK2-plant2 IVGYINMEQD----EQSGSLYIFLEYVSGGSIQRQAAYFIFSYHLFLLNSMLE--RF-GR NPK1-2_Smoe_NPK1 IVKYRGSIKT------KTHLYIILEYVENGSLA----------------SIVKPNKF-GA NPK1-1_Smoe_NPK1 IVKYRGSIKT------KTHLYIILEYVENGSLA----------------SIVKPNKF-GA STE11-p2_e-2_Smoe_STE11-plant1 IVQYLGTQKT------KDKLYIFLELVTQGSIV----------------SQYK--HF-EM STE11-p2_j_Smoe_STE11-plant1 ---------------------------MKCSLA----------------SVIK--ES-NG STE11-p2_e-1_Smoe_STE11-plant1 IVQYLGTQKT------NDKLYIFLELVTQGSIV----------------SQYK--HF-EM STE11-p2_g_Smoe_STE11-plant2 IVQYYGSEAV------EDNLYIYLEYVSGGSIH----------------KLLQ--DY-GP STE11-p2_c_Smoe_STE11-plant2 IVQYYGSESM------KDRLHIYLEFASGGSIQ----------------KLLH--EY-GA STE11-p2_f_Smoe_STE11-plant2 IVQYLGSEML------DDSLYIYLEFVSGGSIH----------------KVLQ--EY-GA STE11-p2_d-1_Smoe_STE11-plant2 IVQYYGSETM------EDGLYIYLEYVSGGSIH----------------KLLQ--EY-GA STE11-p2_d-2_Smoe_STE11-plant2 IVQYYGSETM------EDGLYIYLEYVSGGSIH----------------KLLQ--EY-GA STE11-p3-1_Smoe_STE11-plant3 IVKCLGSAWSSSAESGQPVRSVFLEYMPGGSIA----------------DLMA-KLG-GK STE11-p3-2_Smoe_STE11-plant3 IVKCLGSAWSSSAESGQPVRSVFLEYMPGGSIA----------------DLMA-KLG-GK GK076_Glam_CDC15 LVKYIEAFAD------KEYFYVVMEFVPN-SLD----------------QIIA--H--QR GK077_Glam_CDC15 IVKYRGCFLE------QNYLYIILELVDFGSLQ----------------TLIK--QY-DD GK078_Glam_STE11-Unclassified IVNIYDIEVS----DDGNKLLIVMDFIAGGSLA----------------SLSK--SF-KG : MEKK15_Hsap_MEKK15 LP--EMVFCKYT--------KQILQGVAYLHEN-CVVH-RDIK---------GNNVM-LM MAP3K7_Hsap_ASK MK--EPTIKFYT--------KQILEGLKYLHEN-QIVH-RDIK---------GDNVL-VN MAP3K6_Hsap_ASK LKDNESTISFYT--------RQILQGLGYLHDN-HIVH-RDIK---------GDNVL-IN MAP3K5_Hsap_ASK LKDNEQTIGFYT--------KQILEGLKYLHDN-QIVH-RDIK---------GDNVL-IN MAP3K4_Hsap_MEKK4 LQ--EHVIRLYS--------KQITIAINVLHEH-GIVH-RDIK---------GANIF-LT MAP3K3_Hsap_MEKK2 LT--ESVTRKYT--------RQILEGMSYLHSN-MIVH-RDIK---------GANIL-RD MAP3K2_Hsap_MEKK2 LT--ENVTRKYT--------RQILEGVHYLHSN-MIVH-RDIK---------GANIL-RD MAP3K1_Hsap_MEKK1 FK--ESVVINYT--------EQLLRGLSYLHEN-QIIH-RDVK---------GANLL-ID MEKK15_Mmus_MEKK15 LP--EMVFCKYT--------RQILQGVAYLHDN-CVVH-RDIK---------GNNVM-LM MAP3K7_Mmus_ASK MK--EPTIKFYT--------KQILEGLKYLHEN-QIVH-RDIK---------GDNVL-VN MAP3K6_Mmus_ASK LKDNESTISFYT--------RQILQGLSYLHEN-RIVH-RDIK---------GDNVL-IN MAP3K5_Mmus_ASK LKDNEQTIGFYT--------KQILEGLKYLHDN-QIVH-RDIK---------GDNVL-IN MAP3K4_Mmus_MEKK4 LQ--EHVIRLYT--------KQITVAINVLHEH-GIVH-RDIK---------GANIF-LT MAP3K3_Mmus_MEKK2 LT--ESVTRKYT--------RQILEGMSYLHSN-MIVH-RDIK---------GANIL-RD MAP3K2_Mmus_MEKK2 LT--ENVTRKYT--------RQILEGVHYLHSN-MIVH-RDIK---------GANIL-RD MAP3K1_Mmus_MEKK1 FK--ESVVINYT--------EQLLRGLSYLHEN-QIIH-RDVK---------GANLL-ID nsy-1_Cele_ASK MN--ENAMNYYG--------KQILEGLKYLHEL-KIVH-RDIK---------GDNVL-VN B0414.7_Cele_MEKK4 MD--LKMVRQYT--------NSLLRAVQYLHSH-KIIH-RDIK---------PANIF-LD STE11_Scer_STE11-Unclassified FE--ESLITNFT--------RQILIGVAYLHKK-NIIH-RDIK---------GANIL-ID SSK22_Scer_STE11-Unclassified ED--EMVTQVYT--------FELLEGLAYLHQS-GVVH-RDIK---------PENIL-LD SSK2_Scer_STE11-Unclassified ED--EMVTQVYT--------LQLLEGLAYLHES-GIVH-RDVK---------PENIL-LD CDC15_Scer_CDC15 LS--ENESKTYV--------TQTLLGLKYLHGE-GVIH-RDIK---------AANIL-LS BCK1_Scer_STE11-Unclassified FD--EPLIKHLT--------TQVLKGLAYLHSK-GILH-RDMK---------ADNLL-LD Pk92B_Dmel_ASK LKDNESTMAFYS--------KQILEGLKYLHEQ-DIVH-RDIK---------GDNVL-VN Mekk1_Dmel_MEKK4 LP--EALTRRFT--------AQLLSGVSELHKH-GIVH-RDIK---------TANIFLVD DDB0229877_Ddis_CDC15 FQ--EPLLSRYF--------SQVLKGLAYLHEK-GVIH-RDIK---------SDNIL-IT DDB0229896_Ddis_CDC15 FP--ETLVCVYI--------RQVLEGLVYLHEQ-GVVH-RDIK---------GANIL-TT DDB0229915_Ddis_CDC15 LS--EELCIIYL--------YQMLQGLAYLHSN-KVIH-RDIK---------ASNIL-IT DDB0229971_Ddis_CDC15 FP--ESLICNYV--------ENVLKGLVYLHQE-GVIH-RDIK---------AANIL-IN DDB0231212_Ddis_CDC15 LP--ESLVTVYI--------AQVLNGLEYLHRQ-GVIH-RDIK---------AANLL-IS MEKKalpha_Ddis_STE11-Unclassified FS--ENVIKVYT--------KQILQGLSFLHAN-SIIH-RDIK---------GANIL-ID 11359_Tthe_STE11-Unclassified FN--EKVISIYT--------NQVLQGLKYLHSN-HVFH-RDIK---------GGNIL-ID 15684_Tthe_STE11-Unclassified FS--EPLIRKYT--------TDILYGLQYLHYH-GITH-RDIK---------GANIL-VD 18758_Tthe_STE11-Unclassified LE--EQTIKVYA--------RQILSGIQYLHSQ-KVIH-KDIK---------GANIL-VG 23105_Tthe_STE11-Unclassified FE--EALIKKFV--------KQIISGLAYLHSQ-GIVH-RDIKLTYINKILQGANIL-TD 29763_Tthe_STE11-Unclassified FN--ETLIRKFT--------QQILKGLEYLHAH-EIIH-RDIK---------GANVL-VD 4322_Tthe_CDC15 FQ--ESLVIIFI--------KQVLRGLEYLHRQ-GIVH-RDIK---------GANIL-TT 6622_Tthe_STE11-Unclassified FD--EEVIQKFV--------KQLLEGLIYLHSK-GVIH-RDLK---------GANIL-SD 7147_Tthe_STE11-Unclassified FD--ETKAAIYT--------KQVLEGLDYLHKN-NIIH-RDLK---------GANLL-LD MEKK1_Spur_MEKK1 FS--NAVTVKYI--------HQVCLGLAYLHDN-RVIH-RDLK---------GANLL-MD MEKK2_Spur_MEKK2 LT--DTVTRKYT--------RQILEGTAYLHDH-HIVH-RDIK---------GANVL-R- MEKK4_Spur_MEKK4 LQ--EHEIS--------------------------LII-KNMN---------DLNQ---- ASK_Spur_ASK LKDHEDTIIYYT--------KQILEGLRYLHDQ-KIVH-RDIK---------GDNVL-VN MEKK15_Spur_MEKK15 LD--ETVFCRYT--------KQILEGTQYLHEN-NVIH-RDIK---------GANIM-LM CC1G_00852_Ccin_CDC15 LN--ERLVASYV--------VKILEGLHYLHTS-DVVH-CDLK---------AANIL-TT CC1G_05008_Ccin_CDC15 FP--ENLVAVYI--------SQVLEGLVYLHDQ-GVIH-RDIK---------GANIL-TN CC1G_12014_Ccin_STE11-Unclassified FE--EPLVRNFV--------RQILQGLSYLHER-DIIH-RDIK---------GANIL-VD CC1G_10524_Ccin_STE11-Unclassified LR--EEVTKSWL--------RQILQGLDYLHGK-GILH-RDLK---------ADNIL-VD CC1G_13687_Ccin_STE11-Unclassified ED--ERILQLYT--------VQMLDGLSYLHSQ-GIVH-RDIK---------PDNIL-LD CC1G_10513_Ccin_STE11-Unclassified FS--ENVTKSFT--------GQILSGLEYLHSK-GILH-RDLK---------ADNIL-VE AqueK224_Aque_ASK LINDEGTIRHYT--------RQILKGLGYLHNQ-KIVH-RDIK---------GDNVL-VN AqueK225_Aque_MEKK1 LS--VEDAHNYA--------CQLFDALDYLHGKINLVH-SDIK---------PGNLL-ID AqueK226_Aque_MEKK15 LN--EKTIVRYV--------RQMGRGLNYLHNN-GVIH-RDIK---------GANVM-VS AqueK227_Aque_MEKK2 LS--EALTRKYT--------RQILEGVAFLHGM-KIVH-RDIK---------GANIL-RD AqueK228_Aque_MEKK4 LE--ERMIRLYT--------RDLLRAVDVLHDR-GIVH-RDIK---------GANIF-LS MEKK2-p1_a_Smoe_MEKK2-plant1 FT--EPVIRMYT--------RQLLLGLEYLHQN-KIMH-RDIK---------GANIL-VD MEKK2-p1_b_Smoe_MEKK2-plant1 FT--EPVIRMYT--------RQLLLGLEYLHQN-KIMH-RDIK---------GANIL-VD STE11-p2_b-2_Smoe_MEKK2-plant2 FS--ESLVRIYT--------RQLLLGLEYLHAN-KIVH-RDIK---------GGNVL-VD STE11-p2_a_Smoe_MEKK2-plant2 FS--EPLVRVYT--------RQLLLGLQYLHEN-RIVH-RDIK---------GGNVL-VD STE11-p2_b-1_Smoe_MEKK2-plant2 FS--ESLVRIYT--------RQLLLGLEYLHAN-KIVH-RDIK---------GGNVL-VD STE11-p2_h_Smoe_MEKK2-plant2 FS--EPLVRVYT--------RQLLLGLQYLHEN-RIVH-RDIK---------GGNVL-VD NPK1-2_Smoe_NPK1 FP--ESLVAVYIAQALLTRYSQVLEGLAYLHEQ-GVIH-RDIK---------GANIL-TT NPK1-1_Smoe_NPK1 FP--ESLV-------------AVLEGLAYLHEQ-GVIH-RDIK---------GANIL-TT STE11-p2_e-2_Smoe_STE11-plant1 FD--EQ-IRKYT--------KQILSGLKYLHEK-KVVH-RDIK---------CANIL-VH STE11-p2_j_Smoe_STE11-plant1 LD--ESKLRVYT--------RQILSGLEYLHRM-NIVHSRDVK---------CGNIL-LD STE11-p2_e-1_Smoe_STE11-plant1 FD--EQ-IRKYT--------KQILSGLKYLHEK-KVVH-RDIK---------CANIL-VH STE11-p2_g_Smoe_STE11-plant2 FK--ESVIRRYT--------RQILSGLSFLHSV-ETVH-RDIK---------GANIL-VD STE11-p2_c_Smoe_STE11-plant2 FE--EPVIKSYA--------RQIVCGLAYLHSK-QTVH-RDIK---------GANVL-ID STE11-p2_f_Smoe_STE11-plant2 FK--EPVIRSYT--------QQILSGLQYLHSM-NKVH-RDIK---------GANIL-VD STE11-p2_d-1_Smoe_STE11-plant2 FK--EPVIRSYT--------RQILSGLAYLHST-STVH-RDIK---------GANIL-VD STE11-p2_d-2_Smoe_STE11-plant2 FK--EPVIRSYT--------RQILSGLAYLHST-STVH-RDIK---------GANIL-VD STE11-p3-1_Smoe_STE11-plant3 LH--ESLARIYT--------RGILEGLDFLHRR-GIVH-CDIK---------GKNVL-VG STE11-p3-2_Smoe_STE11-plant3 LH--ESLARIYT--------RGILEGLEFLHRR-GIVH-CDIK---------GKNVL-VG GK076_Glam_CDC15 ST--EHLAALYV--------TQIVKGLIFIHYN-GYTH-KRIT---------PEHIL-IT GK077_Glam_CDC15 LG--ENVVACYI--------YQILLGLKYLHEQ-GIIH-KDIK---------AANIL-MT GK078_Glam_STE11-Unclassified IP--EILCRRYA--------RQILEAIKHMHRQ-NVAH-LDLK---------CSNIM-IG :. : MEKK15_Hsap_MEKK15 P---TG-IIKLIDFGCARRLAWAGLN------------G--------------------- MAP3K7_Hsap_ASK T--YSG-VVKISDFGTSKRLAGVN------------------------------------ MAP3K6_Hsap_ASK T--FSG-LLKISDFGTSKRLAGIT------------------------------------ MAP3K5_Hsap_ASK T--YSG-VLKISDFGTSKRLAGIN------------------------------------ MAP3K4_Hsap_MEKK4 S---SG-LIKLGDFGCSVKLKNNAQT---------------------------------- MAP3K3_Hsap_MEKK2 S---AG-NVKLGDFGASKRLQTICM----------------------------------- MAP3K2_Hsap_MEKK2 S---TG-NVKLGDFGASKRLQTICL----------------------------------- MAP3K1_Hsap_MEKK1 S---TGQRLRIADFGAAARLASKG------------------------------------ MEKK15_Mmus_MEKK15 P---TG-IIKLIDFGCAKRLAWAGLN------------G--------------------- MAP3K7_Mmus_ASK T--YSG-VVKISDFGTSKRLAGIN------------------------------------ MAP3K6_Mmus_ASK T--FSG-LLKISDFGTSKRLAGIT------------------------------------ MAP3K5_Mmus_ASK T--YSG-VLKISDFGTSKRLAGIN------------------------------------ MAP3K4_Mmus_MEKK4 S---SG-LIKLGDFGCSVKLKNNAQT---------------------------------- MAP3K3_Mmus_MEKK2 S---AG-NVKLGDFGASKRLQTICM----------------------------------- MAP3K2_Mmus_MEKK2 S---TG-NIKLGDFGASKRLQTICL----------------------------------- MAP3K1_Mmus_MEKK1 S---TGQRLRIADFGAAARLASKG------------------------------------ nsy-1_Cele_ASK T--YSG-VCKISDFGTCKRLAGLN------------------------------------ B0414.7_Cele_MEKK4 K---CT-VLKLGDFGCSSRLVESSTV---------------------------------- STE11_Scer_STE11-Unclassified I---KG-CVKITDFGISKKLSPLNK----------------------------------- SSK22_Scer_STE11-Unclassified F---NG-IIKYVDFGTARTVVGSRTR------------TVRNAAV--------------- SSK2_Scer_STE11-Unclassified F---NG-VIKYVDFGAAKKIANNGTR------------LASMNKIENADGEHEDVTHVSD CDC15_Scer_CDC15 A---DN-TVKLADFGVSTIVNS-------------------------------------- BCK1_Scer_STE11-Unclassified Q---DG-ICKISDFGISRKSKDIY------------------------------------ Pk92B_Dmel_ASK T--YSG-VVKISDFGTSKRLARIN------------------------------------ Mekk1_Dmel_MEKK4 G---SN-SLKLGDFGSAVKIQAHT-T---------------------------------- DDB0229877_Ddis_CDC15 K---EG-VIKLADFGSCTYSAI--D----------------------------------- DDB0229896_Ddis_CDC15 K---EG-KIKLADFGVATKFDDT------------------------------------- DDB0229915_Ddis_CDC15 ---KEG-VIKLADFGVASQIDSESQ----------------------------------- DDB0229971_Ddis_CDC15 K---AG-EAKLSDFGTAGEIIKESD----------------------------------- DDB0231212_Ddis_CDC15 ---TDG-SIKLADFGVATKVSDLSS----------------------------------- MEKKalpha_Ddis_STE11-Unclassified T---KG-IVKLSDFGCSKSFSGIV------------------------------------ 11359_Tthe_STE11-Unclassified T---DG-TIKLTDFGTLKLHKKDAYINH----------SKSQS----------------- 15684_Tthe_STE11-Unclassified S---DG-VCKLADFGLAKSISQEID----------------------------------- 18758_Tthe_STE11-Unclassified S---DG-IVKLSDFGCAKQLELTLN----------------------------------- 23105_Tthe_STE11-Unclassified G---NG-TVKLADFGAARYRDTICLP------------T--------------------- 29763_Tthe_STE11-Unclassified K---DG-NCKLADFGSAKKIVEEK------------------------------------ 4322_Tthe_CDC15 KNNKSG-VIKLTDFGVATHLADDDK----------------------------------- 6622_Tthe_STE11-Unclassified G---QG-NVKLADFGAARNIENILQH------------S--------------------- 7147_Tthe_STE11-Unclassified A---EG-RAKLTDFGTAKQIEFDLRKSQ----------VK-------------------- MEKK1_Spur_MEKK1 S---TGHHLRIADLGTAGKMNADI------------------------------------ MEKK2_Spur_MEKK2 S---SG-NVKLADFGASTRLQTIHS----------------------------------- MEKK4_Spur_MEKK4 ------------------------HF---------------------------------- ASK_Spur_ASK T--YSG-VVKISDFGTSKRLAGLN------------------------------------ MEKK15_Spur_MEKK15 S---TG-VIKLIDFGCAKRLCIQI-S---------------------------------- CC1G_00852_Ccin_CDC15 K---NG-NVKLSDFGVSLNLRAME------------------------------------ CC1G_05008_Ccin_CDC15 K---DG-TVKLADFGVAARTGGV------------------------------------- CC1G_12014_Ccin_STE11-Unclassified N---KG-GVKISDFGISKKVDDNLLG---------------------------------- CC1G_10524_Ccin_STE11-Unclassified H---SG-VCKISDFGISKKAGEINR----------------------------------- CC1G_13687_Ccin_STE11-Unclassified Q---LG-RIKFVDFGAAKILAKNQHT------------LQRSRRST-------DAA-F-- CC1G_10513_Ccin_STE11-Unclassified M---TG-ICKISDFGISKRTDDLH------------------------------------ AqueK224_Aque_ASK M--YSG-QIKISDFG--------------------------------------------- AqueK225_Aque_MEKK1 E--NVQ-RLKVTDFGCSQVLEDSHQ----------------------------------- AqueK226_Aque_MEKK15 A---HG-TVKLIDFGCAKRHCLD--Q---------------------------------- AqueK227_Aque_MEKK2 S---NG-NVKLADFGASKRLQTIR------------------------------------ AqueK228_Aque_MEKK4 D---D--SVKLGDFGLSVQLHNVNKT---------------------------------- MEKK2-p1_a_Smoe_MEKK2-plant1 N---QG-HIKVADFGASKKVLELA------------------------------------ MEKK2-p1_b_Smoe_MEKK2-plant1 N---QG-HIKVADFGASKKVLELA------------------------------------ STE11-p2_b-2_Smoe_MEKK2-plant2 A---DG-VVKLADFGASKAFHDPT------------------------------------ STE11-p2_a_Smoe_MEKK2-plant2 A---IG-VVKLADFGASKAFHDPT------------------------------------ STE11-p2_b-1_Smoe_MEKK2-plant2 A---DG-VVKLADFGASKAFHDPT------------------------------------ STE11-p2_h_Smoe_MEKK2-plant2 A---IG-VVKLADFGASKAFHDPT------------------------------------ NPK1-2_Smoe_NPK1 K---EG-FVKLADFGVATKLTEADV----------------------------------- NPK1-1_Smoe_NPK1 KEVFQG-FVKLADFGVATKLTEADV----------------------------------- STE11-p2_e-2_Smoe_STE11-plant1 A---HG-TVKLADFGMAKQASY-------------------------------------- STE11-p2_j_Smoe_STE11-plant1 P---NG-KAKLADFGLAKKHRSHQ------------------------------------ STE11-p2_e-1_Smoe_STE11-plant1 A---HG-TVKLADFGMAKQASY-------------------------------------- STE11-p2_g_Smoe_STE11-plant2 T---NG-VVKLGDFGMAKHVRFVSSLIFFR-HSPRDCFQ--------------------- STE11-p2_c_Smoe_STE11-plant2 S---DG-NVKLADFGMAKHVTA-------------------------------------- STE11-p2_f_Smoe_STE11-plant2 T---NG-EVKLADFGMAKHISS-------------------------------------- STE11-p2_d-1_Smoe_STE11-plant2 T---NG-IVKLADFGMAKHVLNVFSSFLSLLLTSVSVFQ--------------------- STE11-p2_d-2_Smoe_STE11-plant2 T---NG-IVKLADFGMAKHVLNVFSLFLSLLLTSVSVFQ--------------------- STE11-p3-1_Smoe_STE11-plant3 A---TG--VKLADFGAAKRLSGAAP----------------------------------- STE11-p3-2_Smoe_STE11-plant3 A---TG--VKLADFGAAKRLSGAAH----------------------------------- GK076_Glam_CDC15 N---DG-FVKISDFVLQNAYFADG------------------------------------ GK077_Glam_CDC15 S---SG-LCKLTDFGLSQRLQDV------------------------------------- GK078_Glam_STE11-Unclassified G---DG-LVKLVDFGTATRLARDDII------------NE------LQRRKETEADPKKP MEKK15_Hsap_MEKK15 -----THSDMLKS-MHGTPYWMAPEV-------INE----------SGY-G-RKSDIWSI MAP3K7_Hsap_ASK --------PCTET-FTGTLQYMAPEI-------IDQG--------PRGY-G-APADIWSL MAP3K6_Hsap_ASK --------PCTET-FTGTLQYMAPEI-------IDQG--------PRGY-G-KAADIWSL MAP3K5_Hsap_ASK --------PCTET-FTGTLQYMAPEI-------IDKG--------PRGY-G-KAADIWSL MAP3K4_Hsap_MEKK4 ------MPGEVNS-TLGTAAYMAPEV-------ITRAK-------GEGH-G-RAADIWSL MAP3K3_Hsap_MEKK2 ------SGTGMRS-VTGTPYWMSPEV-------ISG----------EGY-G-RKADVWSL MAP3K2_Hsap_MEKK2 ------SGTGMKS-VTGTPYWMSPEV-------ISG----------EGY-G-RKADIWSV MAP3K1_Hsap_MEKK1 ----TGAGEFQGQ-LLGTIAFMAPEV-------LRG----------QQY-G-RSCDVWSV MEKK15_Mmus_MEKK15 -----THSDMLKS-MRGTPYWMAPEV-------INE----------SGY-G-RKSDIWSI MAP3K7_Mmus_ASK --------PCTET-FTGTLQYMAPEI-------IDQG--------PRGY-G-APADIWSL MAP3K6_Mmus_ASK --------PCTET-FTGTLQYMAPEI-------IDQG--------PRGY-G-KAADIWSL MAP3K5_Mmus_ASK --------PCTET-FTGTLQYMAPEI-------IDKG--------PRGY-G-KAADIWSL MAP3K4_Mmus_MEKK4 ------MPGEVNS-TLGTAAYMAPEV-------ITRAK-------GEGH-G-RAADIWSL MAP3K3_Mmus_MEKK2 ------SGTGIRS-VTGTPYWMSPEV-------ISG----------EGY-G-RKADVWSL MAP3K2_Mmus_MEKK2 ------SGTGMKS-VTGTPYWMSPEV-------ISG----------EGY-G-RKADIWSV MAP3K1_Mmus_MEKK1 ----TGAGEFQGQ-LLGTIAFMAPEV-------LRG----------QQY-G-RSCDVWSV nsy-1_Cele_ASK --------PVTET-FTGTLQYMAPEV-------IDHG--------QRGY-G-APADIWSF B0414.7_Cele_MEKK4 -------YGEFQT-TAGTPQFMAPEI-------YSYGEKDETTGSYSGY-G-RSVDIWAL STE11_Scer_STE11-Unclassified ------KQNKRAS-LQGSVFWMSPEV-------VKQ----------TAT-T-AKADIWST SSK22_Scer_STE11-Unclassified -QDFGVETKSLNE-MMGTPMYMAPET-------ISGSA-------VKGK-L-GADDVWAL SSK2_Scer_STE11-Unclassified SKAVKNNENALLD-MMGTPMYMAPES-------ITGST-------TKGK-L-GADDVWSL CDC15_Scer_CDC15 ---------SALT-LAGTLNWMAPEI-------LGN----------RGA-S-TLSDIWSL BCK1_Scer_STE11-Unclassified -------SNSDMT-MRGTVFWMAPEM-------VDT---------KQGY-S-AKVDIWSL Pk92B_Dmel_ASK --------PMTET-FTGTLQYMAPEV-------IDQG--------VRGY-G-PAADIWSF Mekk1_Dmel_MEKK4 ------VPGELQG-YVGTQAYMAPEV-------FTKTN-------SDGH-G-RAADIWSV DDB0229877_Ddis_CDC15 ---------RKLT-VVGTPFWMAPEV-------IQMD--------MNAR-S-TACDIWSL DDB0229896_Ddis_CDC15 ---------SAAA-VVGTPYWMAPEI-------IEL----------NGA-T-TKSDIWSV DDB0229915_Ddis_CDC15 ---------LRFS-VVGTPYWMAPES-------IEI----------SGC-S-SASDIWSL DDB0229971_Ddis_CDC15 ---------KRYS-VVGTPYWMAPEV-------IEI----------SGH-C-QVSDIWSL DDB0231212_Ddis_CDC15 -------DNPDDT-FAGTPYWMAPEV-------IQM----------QGI-S-TACDVWSL MEKKalpha_Ddis_STE11-Unclassified --------SQFKS-MQGTPYWMAPEV-------IKQ----------TGH-G-RSSDIWSL 11359_Tthe_STE11-Unclassified --QLSHNQLDYGTIQSQKPFWTAPEV-------LKN---------EDSH-D-ASSDIWSV 15684_Tthe_STE11-Unclassified -------EGQLKL-PQGTPNWMAPEV-------CR-----------SGT-C-RFSDIWSL 18758_Tthe_STE11-Unclassified -----SNKEMNKT-LKGSVPWMSPEI-------VTQ----------TKY-D-TKADIWSF 23105_Tthe_STE11-Unclassified ----ADGSEFCNS-IKGSLYWMAPEL-------LNQ----------ESH-G-RKSDIWSL 29763_Tthe_STE11-Unclassified --------GHNDS-IRGTPYWMAPET-------IKQ----------LGS-G-------SI 4322_Tthe_CDC15 ---------SSTQ-CVGTPYWMAPEV-------IIDS---------DGHIS-TSCDIWSL 6622_Tthe_STE11-Unclassified ----LSQSEFCNS-IKGSLYWMAPEL-------IKN----------EKH-G-RRIDVWSL 7147_Tthe_STE11-Unclassified ---EEDIAKMNKS-LKGTPNWMAPEV-------IER----------TGH-T-TSADIWSI MEKK1_Spur_MEKK1 ----TRTDEFKGQ-FLGTISFMAPEV-------LRG----------EPY-G-RSCDIWSV MEKK2_Spur_MEKK2 ------HITGMKT-VTGTPYWMSPEI-------ING----------EGY-G-RRADVWSI MEKK4_Spur_MEKK4 ------MPYKIYS-KMLSAAYMAPEV-------INQTG-------KDGY-G-RQADIWSL ASK_Spur_ASK --------PAASS-FKGTLQYMAPEV-------IDKG--------LRGH-G-APADIWSL MEKK15_Spur_MEKK15 -----RSQNVLKS-MRGTPYWMAPEV-------IME----------TGH-G-KKSDIWSI CC1G_00852_Ccin_CDC15 --------REIKD-VAGTPNWMAPEV-------IEL----------KGA-S-IKSDIWSL CC1G_05008_Ccin_CDC15 ---------VDGA-VVGSPYWMAPEV-------IEQ----------SGA-T-TASDIWSV CC1G_12014_Ccin_STE11-Unclassified -----GNRLHRPS-LQGSVFWMAPEV-------VKQ----------TGH-T-KKADIWSV CC1G_10524_Ccin_STE11-Unclassified -------AKAHTG-MKGTSFWMAPEI-------LSPG--------EKGY-D-VKVDIWSV CC1G_13687_Ccin_STE11-Unclassified -NAANGIGVMSNG-LTGTPMYMSPEM-------IKNDR--------RGR-H-GATDIWSL CC1G_10513_Ccin_STE11-Unclassified -------GGAFTA-MQGTVFWMAPEV-------INTQ--------KKGY-N-FKIDIWSV AqueK224_Aque_ASK -----------------TFQFMAPEV-------IASG--------QRGY-G-PPADVWSL AqueK225_Aque_MEKK1 -----GYCMRGDA-NAGTVHYNPPEH-------YSE----------FRC-S-YALDIWQA AqueK226_Aque_MEKK15 -------SLGFHS-VRGTPYWMAPEV-------ICG----------RGY-G-RKSDIWSL AqueK227_Aque_MEKK2 --------SGIGS-VHGTPYWMAPEV-------IKG---------DDPY-T-FKADIWSV AqueK228_Aque_MEKK4 ------APQEIKH-QRGTIPYMSPEV-------VLM----------QDM-G-RPMDIWAV MEKK2-p1_a_Smoe_MEKK2-plant1 ------TISEAKS-MKGTPYWMAPEV-------VRQ----------TGH-N-WQADIWSV MEKK2-p1_b_Smoe_MEKK2-plant1 ------TISEAKS-MKGTPYWMAPEV-------VRQ----------TGH-N-WQADIWSV STE11-p2_b-2_Smoe_MEKK2-plant2 ------ITDGCKS-IRGSVFWMAPEV-------IKG----------DGY-G-RRADIWSV STE11-p2_a_Smoe_MEKK2-plant2 ------VTNECKS-IRGSVFWMAPEV-------IKG----------DGY-G-RRADIWSV STE11-p2_b-1_Smoe_MEKK2-plant2 ------ITDGCKS-IRGSVFWMAPEV-------IKG----------DGY-G-RRADIWSV STE11-p2_h_Smoe_MEKK2-plant2 ------VTNECKS-IRGSVFWMAPEV-------IKG----------DGY-G-RRADIWSV NPK1-2_Smoe_NPK1 ---------NTHS-VVGTPYWMAPEV-------VEM----------SGV-S-ASSDIWSV NPK1-1_Smoe_NPK1 ---------NTHS-VVGTPYWMAPEV-------VEM----------SGV-S-ASSDIWSV STE11-p2_e-2_Smoe_STE11-plant1 --------FFMRS-CKGSVYWMAPEV-------INP---------KKTA-G-FPADIWSL STE11-p2_j_Smoe_STE11-plant1 -----IDYSVAKS-CKGTFVYMAPEV-------LLT---------EGTY-G-LAADVWSL STE11-p2_e-1_Smoe_STE11-plant1 --------FFMRS-CKGSVYWMAPEV-------INP---------KKTA-G-FPADIWSL STE11-p2_g_Smoe_STE11-plant2 ----ITAQSFPLS-CKGSPYWMAPEI-------LKS---------THGY-D-LSVDIWSL STE11-p2_c_Smoe_STE11-plant2 -------KSFARS-LKGSPYWMAPERSLTFFQILKSR--------CSGY-D-LSVDIWSL STE11-p2_f_Smoe_STE11-plant2 -------SSLVLS-FKGSPYWMAPEV-------FKS----------NAQ-S-YPVDIWSL STE11-p2_d-1_Smoe_STE11-plant2 ----LSVESFPLS-FKGSPYWMAPEV-------IKQ---------THGY-D-LSVDVWSL STE11-p2_d-2_Smoe_STE11-plant2 ----LSVESFPLS-FKGSPYWMAPEV-------IKQ---------THGY-D-LSVDVWSL STE11-p3-1_Smoe_STE11-plant3 ----YQHHQQSPM-IKGTPLWMAPEV-------VRQ----------EEQ-G-TASDIWSL STE11-p3-2_Smoe_STE11-plant3 ----YQHHQQSPM-IKGTPLWMAPEV-------VRQ----------EEQ-G-TASDIWSL GK076_Glam_CDC15 -------D--------KDVRDMAPEE-------ILL----------LGR-T-TAVDIWNL GK077_Glam_CDC15 ---------DPTV-VEGSPYWLAPEV-------INE----------EGV-S-TKSDVWSL GK078_Glam_STE11-Unclassified GLPSEAAKKFNLG-IKGSPYWIAPEC-------VRS----------TLY-DIFKADIWSI .** MEKK15_Hsap_MEKK15 GCTVF----EMATGKPPLASMDR-----------M-AAMFYIGAHR--------GLMPPL MAP3K7_Hsap_ASK GCTII----EMATSKPPFHELG-----------EPQAAMFKVGMF---------KIHPEI MAP3K6_Hsap_ASK GCTVI----EMATGRPPFHELG-----------SPQAAMFQVGMY---------KVHPPM MAP3K5_Hsap_ASK GCTII----EMATGKPPFYELG-----------EPQAAMFKVGMF---------KVHPEI MAP3K4_Hsap_MEKK4 GCVVI----EMVTGKRPWHEYEH-----------NFQIMYKVGM-G---------HKPPI MAP3K3_Hsap_MEKK2 GCTVV----EMLTEKPPWAEYE------------AMAAIFKIATQ---------PTNPQL MAP3K2_Hsap_MEKK2 ACTVV----EMLTEKPPWAEFE------------AMAAIFKIATQ---------PTNPKL MAP3K1_Hsap_MEKK1 GCAII----EMACAKPPWNAEKHS---------NHLALIFKIASA---------TTAPSI MEKK15_Mmus_MEKK15 GCTVF----EMATGKPPLASMDR-----------M-AAMFYIGAHR--------GLMPPL MAP3K7_Mmus_ASK GCTII----EMATSRPPFHELG-----------EPQAAMFKVGMF---------KIHPEI MAP3K6_Mmus_ASK GCTVI----EMATGRPPFHELG-----------SPQAAMFQVGMY---------KVHPPV MAP3K5_Mmus_ASK GCTII----EMATGKPPFYELG-----------EPQAAMFKVGMF---------KVHPEI MAP3K4_Mmus_MEKK4 GCVVI----EMVTGKRPWHEYEH-----------NFQIMYKVGM-G---------HKPPI MAP3K3_Mmus_MEKK2 GCTVV----EMLTEKPPWAEYE------------AMAAIFKIATQ---------PTNPQL MAP3K2_Mmus_MEKK2 ACTVV----EMLTEKPPWAEFE------------AMAAIFKIATQ---------PTNPKL MAP3K1_Mmus_MEKK1 GCAII----EMACAKPPWNAEKHS---------NHLALIFKIASA---------TTAPSI nsy-1_Cele_ASK GCTMV----EMATGRPPFVEMQ-----------NPQAAMFRVGMF---------KTHPPI B0414.7_Cele_MEKK4 GATVV----NMMTGKVPFEGQTRH------------QIAFALCFR---------KQKPTY STE11_Scer_STE11-Unclassified GCVVI----EMFTGKHPFPDFSQ-----------M-QAIFKIGTN----------TTPEI SSK22_Scer_STE11-Unclassified GCVVL----EMATGRRPWSNLDN-----------EWAIMYHVAA-G---------RIPQL SSK2_Scer_STE11-Unclassified GCVVL----EMITGRRPWANLDN-----------EWAIMYHVAA-G---------HTPQF CDC15_Scer_CDC15 GATVV----EMLTKNPPYHNLTD-----------A-NIYYAVEN-D---------TYYP- BCK1_Scer_STE11-Unclassified GCIVL----EMFAGKRPWSNLEV-----------V-AAMFKIGKS---------KSAPPI Pk92B_Dmel_ASK GCTNV----EMATGKPPFIELG-----------SAHAAMFKVGFY---------KKHPNI Mekk1_Dmel_MEKK4 GCVVV----EMASGKRPWAQFDS-----------NFQIMFKVGM-G---------EKPQA DDB0229877_Ddis_CDC15 GCTLL----EMLTGNPPYWDLGT-----------M-PAMFAMVN-N---------PHPPI DDB0229896_Ddis_CDC15 GCTVI----ELLTGSPPYYDLGQ-----------M-PALFRIVQ-D---------DCPPL DDB0229915_Ddis_CDC15 GSTMI----ELLTGNPPYYTLQP-----------M-AAMFRIVS-D---------QHPPF DDB0229971_Ddis_CDC15 GCTII----ELFTSYPPYFDLNP-----------L-GAMYRICQ-D---------DRPPL DDB0231212_Ddis_CDC15 GCTII----ELLTGTPPYFGLAP-----------A-AALYKIVQ-E---------DHPPI MEKKalpha_Ddis_STE11-Unclassified GCVIV----EMATAQPPWSNITE-----------LAAVMYHIASS---------NSIPNI 11359_Tthe_STE11-Unclassified GCLVI----EMITALPPYYNLNDK----------SSQEITKYIMD---------GNIPNF 15684_Tthe_STE11-Unclassified GCTVY----EMITGKPPFSNFLAE------------TIILRVGLL---------KQPPQF 18758_Tthe_STE11-Unclassified GCTIL----EMAQAEAPWSNYQFD---------NPIAAIMKIGLS---------DEIPQI 23105_Tthe_STE11-Unclassified GCTMI----EMATGKHPWPDCR------------TFPQLALIVKT---------NQCPPI 29763_Tthe_STE11-Unclassified GCTVI----EMATAKPPWADKS------------PIQAMFYIANA---------QQPPPI 4322_Tthe_CDC15 GCTII----ELLTGNPPYSYGNP-----------H-HALFRMVS-D---------QHPPL 6622_Tthe_STE11-Unclassified GCTVI----EMASAQHPWENIK------------KFSDLANAVIE---------QQPIPI 7147_Tthe_STE11-Unclassified GCIVI----EMITGKPPYPGLSAK------------EVFTKIASG--------------- MEKK1_Spur_MEKK1 GCCII----EMCTTKPPWNNTAIS---------NHYQLLFKIASA---------NGPPPI MEKK2_Spur_MEKK2 GCTVV----EMLTTKPPWADYE------------AMAAIFKIATK---------ETEPVL MEKK4_Spur_MEKK4 GCVVI----EMVTGKRPWHDYDH-----------EFTIMYKVGE-G---------AVPHI ASK_Spur_ASK GCTIV----EMATGKPPFIELG-----------SPQAAMFKVGFY---------KDHPEI MEKK15_Spur_MEKK15 GCTVF----EMATRKPPWADMPP-----------M-AAIFAIGSG---------DPVPQL CC1G_00852_Ccin_CDC15 GCTHVWYVKEFHRRSLPWFNHD-------------ATVMFRIVE-D---------DMPPL CC1G_05008_Ccin_CDC15 GCVVI----ELLEGRPPYHNLDP-----------M-PALFRIVQ-D---------DCPPI CC1G_12014_Ccin_STE11-Unclassified GCLVV----EMLTGEHPWAQLTQ-----------M-QAIFKIGSS----------ARPTI CC1G_10524_Ccin_STE11-Unclassified GCVAV----EMWTGKRPWYGHEW-----------W-PVLMKVAED---------KSPPPI CC1G_13687_Ccin_STE11-Unclassified GCVIL----QCATGRKPWSNLDN-----------EWAIMFHIGVST---------QHPPL CC1G_10513_Ccin_STE11-Unclassified GCVVL----EMWGGRRPWTGQEM-----------V-TVMFKLYEA---------KLPPPV AqueK224_Aque_ASK GCTVI----EMVTGKPPFFELG-----------PPEAAVFKVGTF---------KEHPEI AqueK225_Aque_MEKK1 GCCII----AMVTGRRPWRSMYLDCRERRYRAEVQQSQIQQICKV---------PYSHHV AqueK226_Aque_MEKK15 GCTMY----EMIFTRPPWGDLPP-----------E-AAMFKIGLG---------QSLPPL AqueK227_Aque_MEKK2 GATVV----EMLKCRPPWSDFE------------PTAAMFKIVMN---------DTKPDL AqueK228_Aque_MEKK4 GCVVV----EMFTSKRPWIELED----------NAMAIMFQLGN-K---------KSPSY MEKK2-p1_a_Smoe_MEKK2-plant1 GCTVI----EMATGKPPWSDQF-----------QEVAALFHIGTT---------KSHPPI MEKK2-p1_b_Smoe_MEKK2-plant1 GCTVI----EMATGKPPWSDQF-----------QEVAALFHIGTT---------KSHPPI STE11-p2_b-2_Smoe_MEKK2-plant2 GCTVI----EMLTATHPWPGID-----------NTWTAIFHIAKA---------SSGPPV STE11-p2_a_Smoe_MEKK2-plant2 GCTVI----EMLTAMHPWPDID-----------NTWSAIFHIAKA---------SSGPPI STE11-p2_b-1_Smoe_MEKK2-plant2 GCTVI----EMLTATHPWPGID-----------NTWTAIFHIAKA---------SSGPPV STE11-p2_h_Smoe_MEKK2-plant2 GCTVI----EMLTAMHPWPDID-----------NTWSAIFHIAKA---------SSGPPI NPK1-2_Smoe_NPK1 GCTVI----ELLTCVPPYYDLQP-----------M-PALFRIVQ-D---------ERPPI NPK1-1_Smoe_NPK1 GCTVI----ELLTCVPPYYDLQP-----------M-PALFRIVQ-D---------AK--- STE11-p2_e-2_Smoe_STE11-plant1 GCTVL----EMATGKPPFSDWE------------WNTVFFRVGR----------GALPEI STE11-p2_j_Smoe_STE11-plant1 GCTVI----EMACGKPPWSGFG------------VRSLTFTSMRD---------GCSPPI STE11-p2_e-1_Smoe_STE11-plant1 GCTVL----EMATGKPPFSDWE------------WNTVFFRVGR----------GALPEI STE11-p2_g_Smoe_STE11-plant2 GCTVI----EMATGKPPWSEFE------------GVAVMFKIGNS---------KETPPI STE11-p2_c_Smoe_STE11-plant2 GCTVI----EMAQARPPWSDYE------------AVPVLYKLATT---------LETPRV STE11-p2_f_Smoe_STE11-plant2 GCTII----EMATGKPPWSQYE------------GIAAMFKIGNS---------KETPTI STE11-p2_d-1_Smoe_STE11-plant2 GCTVL----EMATAKPPWSQYE------------GIAAMFKIGNS---------KEIPSI STE11-p2_d-2_Smoe_STE11-plant2 GCTVL----EMATAKPPWSQYE------------GIAAMFKIGNS---------KEIPSI STE11-p3-1_Smoe_STE11-plant3 GCTVL----EMITGRAPWGDVK-----------HTFSALYRIGCS---------EELPEL STE11-p3-2_Smoe_STE11-plant3 GCTVL----EMITGRAPWGDVK-----------HTFSALYRIGCS---------EELPEL GK076_Glam_CDC15 GLLLF----NCLAREHFFKNMADQ----------EIIRLFQSTNAQNTINELVTFRLAEC GK077_Glam_CDC15 GATMI----ELLTKKPPFHNLTG-----------F-AAMYNIAT-L---------TEMPL GK078_Glam_STE11-Unclassified GCLFI----EMFTTYPPFFQFKQ-----------VPALLYHIATI---------TEPPGL . MEKK15_Hsap_MEKK15 P--DH----FSENAADFVRMCLT--------------------------RDQHERPSALQ MAP3K7_Hsap_ASK P--EA----LSAEARAFILSCFE--------------------------PDPHKRATTAE MAP3K6_Hsap_ASK P--SS----LSAEAQAFLLRTFE--------------------------PDPRLRASAQT MAP3K5_Hsap_ASK P--ES----MSAEAKAFILKCFE--------------------------PDPDKRACAND MAP3K4_Hsap_MEKK4 P--ER----LSPEGKDFLSHCLE--------------------------SDPKMRWTASQ MAP3K3_Hsap_MEKK2 P--SH----ISEHGRDFLRRIF---------------------------VEARQRPSAEE MAP3K2_Hsap_MEKK2 P--PH----VSDYTRDFLKRIF---------------------------VEAKLRPSADE MAP3K1_Hsap_MEKK1 P--SH----LSPGLRDVALRCLE--------------------------LQPQDRPPSRE MEKK15_Mmus_MEKK15 P--AR----FSEPAADFVRLCLT--------------------------RDQHERPSALQ MAP3K7_Mmus_ASK P--EA----LSAEARAFILSCFE--------------------------PDPQKRVTAAD MAP3K6_Mmus_ASK P--GS----LSAEAQAFLLRTFE--------------------------PDPRLRASAQE MAP3K5_Mmus_ASK P--ES----MSAEAKAFILKCFE--------------------------PDPDKRACAND MAP3K4_Mmus_MEKK4 P--ER----LSPEGKAFLSHCLE--------------------------SDPKIRWTASQ MAP3K3_Mmus_MEKK2 P--SH----ISEHGRDFLRRIF---------------------------VEARQRPSAEE MAP3K2_Mmus_MEKK2 P--PH----VSDYTRDFLKRIF---------------------------VEAKLRPSAEE MAP3K1_Mmus_MEKK1 P--SH----LSPGLRDVALRCLE--------------------------LQPQDRPPSRE nsy-1_Cele_ASK P--TE----ITEKCRNFIKSCFL--------------------------PEACDRPSAKD B0414.7_Cele_MEKK4 P--DIA--DKRPDVKRFFDNCFE--------------------------FLPNDRPTAAE STE11_Scer_STE11-Unclassified P--SW----ATSEGKNFLRKAFE--------------------------LDYQYRPSALE SSK22_Scer_STE11-Unclassified PNRDE----MTAAGRALLGKVFG--------------------------SRPH------- SSK2_Scer_STE11-Unclassified PTKDE----VSSAGMKFLERCLI--------------------------QNPSKRASAVE CDC15_Scer_CDC15 P--SS----FSEPLKDFLSKCFV--------------------------KNMYKRPTADQ BCK1_Scer_STE11-Unclassified P--EDTLPLISQIGRNFLDACFE--------------------------INPEKRPTANE Pk92B_Dmel_ASK P--EE----LSANAKNFILRCFA--------------------------ISVMDRPSASQ Mekk1_Dmel_MEKK4 P--ES----LSQEGHDFIDHCLQ--------------------------HDPKRRLTAVE DDB0229877_Ddis_CDC15 P--NN----ISADLKHFLLACFV--------------------------RDINKRPTASQ DDB0229896_Ddis_CDC15 P--EG----ISPPLKDWLMQCFQ--------------------------KDPNLRISAQK DDB0229915_Ddis_CDC15 P--TD----ISKEFLDYFQQSFK--------------------------KDPTQRPTAQE DDB0229971_Ddis_CDC15 P--DD----ISSELANFLERCFC--------------------------KSTEERATAKE DDB0231212_Ddis_CDC15 P--PG----ISAALKDFLLNCFK--------------------------KDENIRSSAKQ MEKKalpha_Ddis_STE11-Unclassified P--SH----MSQEAFDFLNLCFK--------------------------RDPKERPDANQ 11359_Tthe_STE11-Unclassified P--EK----LSEQCLEFLQKTLK--------------------------VNPKERATVNE 15684_Tthe_STE11-Unclassified L--ENL--QISEKLSDFLLHCFQ--------------------------IKPEERWNVDQ 18758_Tthe_STE11-Unclassified P--ET----ISPDLNQFIRKCLQ--------------------------RDPSKRPTATE 23105_Tthe_STE11-Unclassified P--EH----LSDECKDFIRQCCT--------------------------FDKKERPTADV 29763_Tthe_STE11-Unclassified P--EH----LSPVCKDFISKCLK----YQNQIELVDLTKTQQILFLQFRINPNDRYNVRQ 4322_Tthe_CDC15 P--KD----VTPQCLDFLMQCFN--------------------------KEPSQRMDAKS 6622_Tthe_STE11-Unclassified P--QH----LSEECKDFISKCCT--------------------------YDKKMRPKSQQ 7147_Tthe_STE11-Unclassified -------------------GCLQ--------------------------TDPKKRLTTSQ MEKK1_Spur_MEKK1 P--ES----LSPALRDITLRCLE--------------------------AEPSARPGVME MEKK2_Spur_MEKK2 P--QS----VSQDARNFLTLCFK--------------------------KILADRPSAAE MEKK4_Spur_MEKK4 P--DA----MNPEGKEFLSNCLK--------------------------HDCTKRWTANK ASK_Spur_ASK P--ES----LSNAAKEFILRCFE--------------------------PDPEKRATAHD MEKK15_Spur_MEKK15 P--VK----FSEDARMFVNACLT--------------------------RDQDERATASE CC1G_00852_Ccin_CDC15 P--EG----CSELLEDFLKQCLQ--------------------------KDPNNRPTAEL CC1G_05008_Ccin_CDC15 P--EG----ASAIVKDFLYHCFQ--------------------------KDCNLRISAKK CC1G_12014_Ccin_STE11-Unclassified P--SD----ISAEAQDFLQKTFE--------------------------INHELRPHAAE CC1G_10524_Ccin_STE11-Unclassified P--EDI--PMGHLAQSFHNQCFR--------------------------PDPADRPHASV CC1G_13687_Ccin_STE11-Unclassified PEPGQ----LSPLGIDFIKQCLT--------------------------IDPTFRPSAKE CC1G_10513_Ccin_STE11-Unclassified P--DDV--VLSELGDDFRRKCFAIFMTD------------------GACSNPDERPPAAE AqueK224_Aque_ASK P--DV----LSKELKSFLLSCFE--------------------------PEPSKRAIVSE AqueK225_Aque_MEKK1 P--GF----LDPALQQLVQQCLS--------------------------IDYRRRPSLKD AqueK226_Aque_MEKK15 P--KN----SSMELISLYTACLK--------------------------SDPGQRPTAQE AqueK227_Aque_MEKK2 P--PH----CSEQAHNFIELCFI--------------------------KDKNERPSAMD AqueK228_Aque_MEKK4 PA-EK----MNDEMIDFLDLCFE--------------------------TDPKQRAVASK MEKK2-p1_a_Smoe_MEKK2-plant1 P--EH----LSPDAKSFLLKCLQ--------------------------REPRLRPTAAE MEKK2-p1_b_Smoe_MEKK2-plant1 P--EH----LSPDAKSFLLKCLQ--------------------------REPRLRPTAAE STE11-p2_b-2_Smoe_MEKK2-plant2 P--AD----ASEGAKDFLQQCFN--------------------------LEARSRPTASQ STE11-p2_a_Smoe_MEKK2-plant2 P--EH----GSGCVKDFLQQCFQ--------------------------MDPRLRPTATQ STE11-p2_b-1_Smoe_MEKK2-plant2 P--AD----ASECAKDFLQQCFN--------------------------LEARSRPTASQ STE11-p2_h_Smoe_MEKK2-plant2 P--EH----GSGCVKDFLQQCFQ--------------------------MDPRLRPTATQ NPK1-2_Smoe_NPK1 P--EH----LSPGLTDFLHQCFQ--------------------------KDAKLRPDAKT NPK1-1_Smoe_NPK1 -----------------------------------------------------LR----- STE11-p2_e-2_Smoe_STE11-plant1 P--DS----IQGDARDFILECLQ--------------------------ADPSKRPTASK STE11-p2_j_Smoe_STE11-plant1 P--PK----MSTEAVSFIKLCLT--------------------------RDPRRRPSAAA STE11-p2_e-1_Smoe_STE11-plant1 P--DS----IQGDARDFILECLQ--------------------------ADPSKRPTASK STE11-p2_g_Smoe_STE11-plant2 P--PH----LSEECQHFLRLCLQ--------------------------RNPADRPTATE STE11-p2_c_Smoe_STE11-plant2 P--DF----LSDQAKDFLRLCLQ--------------------------RDPSHRPTASQ STE11-p2_f_Smoe_STE11-plant2 P--DT----LSPVAKEFIRLCLQ--------------------------RNPDDRPTASQ STE11-p2_d-1_Smoe_STE11-plant2 P--EY----LTRECKNFLRLCLQ--------------------------RNPAERPTATF STE11-p2_d-2_Smoe_STE11-plant2 P--EY----LTRECKNFLRLCLQ--------------------------RNPAERPTATF STE11-p3-1_Smoe_STE11-plant3 P--RW----LSEQGKDFVMNCLR--------------------------RDPRERWTSAQ STE11-p3-2_Smoe_STE11-plant3 P--WW----LSEQGKDFVMNCLR--------------------------RDPRERWTSAQ GK076_Glam_CDC15 N--LN----VSQACKEFILACLS--------------------------IDYTFRPSAQS GK077_Glam_CDC15 P--PN----ISPECADFLSCCFK--------------------------IDPHERHSCAE GK078_Glam_STE11-Unclassified P--ET----MSDEGRDFLSKCLQ--------------------------INPEARASVDD MEKK15_Hsap_MEKK15 LLKHSFL MAP3K7_Hsap_ASK LLREGFL MAP3K6_Hsap_ASK LLGDPFL MAP3K5_Hsap_ASK LLVDEFL MAP3K4_Hsap_MEKK4 LLDHSFV MAP3K3_Hsap_MEKK2 LLTHHFA MAP3K2_Hsap_MEKK2 LLRHMFV MAP3K1_Hsap_MEKK1 LLKHPVF MEKK15_Mmus_MEKK15 LLKHSFL MAP3K7_Mmus_ASK LLQEGFL MAP3K6_Mmus_ASK LLGDPFL MAP3K5_Mmus_ASK LLIDEFL MAP3K4_Mmus_MEKK4 LLDHAFV MAP3K3_Mmus_MEKK2 LLTHHFA MAP3K2_Mmus_MEKK2 LLRHMFV MAP3K1_Mmus_MEKK1 LLKHPVF nsy-1_Cele_ASK LLQDPFI B0414.7_Cele_MEKK4 LLQTTFA STE11_Scer_STE11-Unclassified LLQHPWL SSK22_Scer_STE11-Unclassified -----YE SSK2_Scer_STE11-Unclassified LLMDPWI CDC15_Scer_CDC15 LLKHVWI BCK1_Scer_STE11-Unclassified LLSHPFS Pk92B_Dmel_ASK LLEDPFL Mekk1_Dmel_MEKK4 LLEHNFC DDB0229877_Ddis_CDC15 LLEHPWI DDB0229896_Ddis_CDC15 LLKHKWI DDB0229915_Ddis_CDC15 LLQHPIF DDB0229971_Ddis_CDC15 LLSHPWI DDB0231212_Ddis_CDC15 LLHHPWV MEKKalpha_Ddis_STE11-Unclassified LLKHPFI 11359_Tthe_STE11-Unclassified LIQLKFI 15684_Tthe_STE11-Unclassified LLQHPFI 18758_Tthe_STE11-Unclassified LLNDSFL 23105_Tthe_STE11-Unclassified LLKHPFL 29763_Tthe_STE11-Unclassified LLNHPFI 4322_Tthe_CDC15 LLNHEWL 6622_Tthe_STE11-Unclassified LFNHPFL 7147_Tthe_STE11-Unclassified LLKTPFI MEKK1_Spur_MEKK1 LLKHPAF MEKK2_Spur_MEKK2 LLRHNFV MEKK4_Spur_MEKK4 LLDHPFL ASK_Spur_ASK LLQDPFL MEKK15_Spur_MEKK15 LLKHPFI CC1G_00852_Ccin_CDC15 LCEHEWL CC1G_05008_Ccin_CDC15 LLKHPWM CC1G_12014_Ccin_STE11-Unclassified LLQHPWL CC1G_10524_Ccin_STE11-Unclassified MLKHPYL CC1G_13687_Ccin_STE11-Unclassified LMDHPWM CC1G_10513_Ccin_STE11-Unclassified LRLHPYL AqueK224_Aque_ASK LLQNSFI AqueK225_Aque_MEKK1 CLG--LL AqueK226_Aque_MEKK15 VLDHAFL AqueK227_Aque_MEKK2 LLSHSFC AqueK228_Aque_MEKK4 LLSHSFV MEKK2-p1_a_Smoe_MEKK2-plant1 LLKVCAL MEKK2-p1_b_Smoe_MEKK2-plant1 LLKVCAL STE11-p2_b-2_Smoe_MEKK2-plant2 ------V STE11-p2_a_Smoe_MEKK2-plant2 VF-YPCL STE11-p2_b-1_Smoe_MEKK2-plant2 ------V STE11-p2_h_Smoe_MEKK2-plant2 LLEHRFV NPK1-2_Smoe_NPK1 LLKHSWI NPK1-1_Smoe_NPK1 ------P STE11-p2_e-2_Smoe_STE11-plant1 LLDHPFV STE11-p2_j_Smoe_STE11-plant1 LLSHPFF STE11-p2_e-1_Smoe_STE11-plant1 LLDHPFV STE11-p2_g_Smoe_STE11-plant2 LMEHPFV STE11-p2_c_Smoe_STE11-plant2 LFFHPWF STE11-p2_f_Smoe_STE11-plant2 LLEHPFV STE11-p2_d-1_Smoe_STE11-plant2 LLGHPFV STE11-p2_d-2_Smoe_STE11-plant2 LLGHPFV STE11-p3-1_Smoe_STE11-plant3 LLQHPFV STE11-p3-2_Smoe_STE11-plant3 LLQHPFV GK076_Glam_CDC15 LLQASFL GK077_Glam_CDC15 LLNHPWL GK078_Glam_STE11-Unclassified LLAHPWV