CLUSTAL W (1.83) multiple sequence alignment TSSK4_Hsap YEVGKAIGHGSYGSVYEAFYTKQK----------------VMVAVKIISK--KKASDDYL TSSK3_Hsap YQLGKTIGEGTYSKVKEAFSKK----------------HQRKVAIKVIDK--MGGPEEFI TSSK2_Hsap YIVGINLGKGSYAKVKSAYSER----------------LKFNVAVKIIDR--KKTPTDFV TSSK1_Hsap YLLGINLGEGSYAKVKSAYSER----------------LKFNVAIKIIDR--KKAPADFL SSTK_Hsap YKLGRTIGEGSYSKVKVATSKK----------------YKGTVAIKVVDR--RRAPPDFV B0511.4_Cele LKFEKVLGSGSYSRVARATFGEK----------------KLEVAAKIINITPTREKEDYI CG14305_Dmel YNVGHKIGEGSYATVITAGYADDH-------------GHGVHLACKIIDK--AKAPTDFV CG9222_Dmel IILGKVIGTGNYAKVKIGFSEEYG----------------KRVAVKIISK--VKAPSEYT SSTK_Mmus YKLGRTIGEGSYSKVKVATSKK----------------YKGTVAIKVVDR--RRAPPDFV TSSK1_Mmus YIMGINLGEGSYAKVKSAYSER----------------LKFNVAVKIIDR--KKAPSDFL TSSK2_Mmus YIVGINLGKGSYAKVKSAYSER----------------LKFNVAVKIIDR--KKTPTDFV TSSK3_Mmus YQLGKTIGEGTYSKVKEAFSKK----------------HQRKVAIKIIDK--MGGPEEFI TSSK4_Mmus YEVGKIIGHGSYGTVYEAYYTKQK----------------VMVAVKIISK--KKASEDYL TSSK5_Mmus LLSSKKIGSGAFSKVYLAYATRERMKHNPRLSSDLRGKRHTMVAIKIVSM--AEAPAEYS W02B12.12_Cele LDTSNKLGRGKYSKVYKAFDRNN----------------NRVVAVKAIDT--QELTTDVK Y38H8A.4_Cele LKFDKILGSGSYSRVARATWGDK----------------KLEVAAKVINITPTREKDDYI TSSK2_Spur YTLGLMLGEGSYAAVYSCQLSN----------------NRGKCAIKIINR--KKAPKDFL TSSK4_Spur FNVQETVGHGSYAAVKCAYSTKHK----------------CKVAIKVVSK--KKAPEDYL TSSK6_Spur FCLAHKLGSGSYSKVRMAVHKT----------------TRKRVAVKIIDR--RRAPRDYQ TSSK3_Spur FNVQGKLGEGTYAKVRRAYSYS----------------EKCRVAIKIVSR--SLNA--FA TSSK5_Spur -----TLGSGTYAKVKLARAMKRKIAQTAKLRDDLRIKGHNMVAIKIISR--RDAPTEYL AqueK086_Aque YILGKTLGSGTYAKVKAAWSKRHQ----------------SLVAIKILNK--SVASRDYL AqueK087_Aque YILQTTIGNGAYAKVKLAHSVSMN----------------KKVAIKIVDK--KKAPHDVL :* * :. * * * :. TSSK4_Hsap NKFLPREIQVM-KVL-RHKYLINFYRAIEST-SRVYIILELAQGGDVLEWIQR------Y TSSK3_Hsap QRFLPRELQIV-RTL-DHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLN------G TSSK2_Hsap ERFLPREMDIL-ATV-NHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKC------Q TSSK1_Hsap EKFLPREIEIL-AML-NHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKT------R SSTK_Hsap NKFLPRELSIL-RGV-RHPHIVHVFEFIEVCNGKLYIVMEAA-ATDLLQAVQR------N B0511.4_Cele KKFLPREKEIV-KLL-KHDNICRLYEMISFQ-DHIIFVNEYCAGGDLLRKMKD------I CG14305_Dmel NKFFPRELEIL-TKI-DHSNIIQIHSILQRG-PKIFIFMRYAENGDLLSHIKR------S CG9222_Dmel QKFLPREIEAV-KGL-HHENLITFYQSIETS-HRVYLIMQLAENGTLLDYVRE------R SSTK_Mmus NKFLPRELSIL-RGV-RHPHIVHVFEFIEVCNGKLYIVMEAA-ATDLLQAVQR------N TSSK1_Mmus EKFLPREIEIL-AML-NHRSIVKTYEIFETSDGKVYIVMELGVQGDLLEFIKT------R TSSK2_Mmus ERFLPREMDIL-ATV-NHRSIIKTYEIFETSDGRIYIVMELGVQGDLLEFIKC------R TSSK3_Mmus QRFLPRELQIV-RTL-DHKNIIQVYEMLESADGKIYLVMELAEGGDVFDCVLN------G TSSK4_Mmus NKFLPREIQVM-KVL-RHKYLINFYQAIETT-SRVYIILELAQGGDVLEWIQR------Y TSSK5_Mmus RKFLPREILSLNATY-KHMNIVQLYETYQNS-QRSYLVLELAARGDLLEHINAVSDLRCC W02B12.12_Cele MKFLPRELSCW-RKL-KNPFVVGLHAQYEAQ-SMIFLTMEYGSQGDLLRYVQE------H Y38H8A.4_Cele KKFLPREKEIV-KLL-KHDNVCRLYEMISFP-DHIIFVTEFCAGGDLLRKMKK------I TSSK2_Spur EKFLPREIKIL-SKV-QHRNIVKCFEIFDTGQGKVYMVLELAGHGDMLEYIKL------R TSSK4_Spur IKFLPREIQVV-KIL-KHPNLICFLQSIETT-SRVYLIMELADNGDLLDFIKA------N TSSK6_Spur DHFLPRELAVI-RQL-QHPNVLRTYEWFEQN-QKVYMVLELAESGDVLEYIRTV----TK TSSK3_Spur E--ISSELKIV-RNM-RHPHIIELLEMFESN-GVIFLIMELARHGDLLEYVQK------K TSSK5_Spur KKFMPREIDAM-RITHKHAHLIQLYEFFRSE-RGVYLVLEYAAHGDVLSYINDSVQ-ETG AqueK086_Aque HKFLPREIDIL-QKI-NHSSIIRVLEIIETD-KLAYFMMELAQNGDLLDYINA------R AqueK087_Aque TKFLPREIDAL-QAMRGHDNIIYLHEVIHTN-DKIFMVMDLADNGDLLDYINS------K :. * : : : :: : TSSK4_Hsap GACSEPLAGKWFSQLTLGIAYLHSKSIVHRDLKLENLLLDKW-ENVKISDFGFAKMVPSN TSSK3_Hsap GPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQ-G-FNLKLTDFGFAKVLPK- TSSK2_Hsap GALHEDVARKMFRQLSSAVKYCHDLDIVHRDLKCENLLLDKD-FNIKLSDFGFSKRCLRD TSSK1_Hsap GALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKD-FNIKLSDFSFSKRCLRD SSTK_Hsap GRIPGVQARDLFAQIAGAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFGRQAH-- B0511.4_Cele VAMKEEDAKFTFRQLIAALTHLQSYNIVHRDLKCENIFMDKH-GNVKLGDFGFSRILKP- CG14305_Dmel GPIDEKQSKIWFFQMSKALKYLHNLDIAHRDLKCENILLSKR-LNIKLADFGFARYCR-D CG9222_Dmel KFLDEPQSRTLFKQLVSAVEYIHSKGVVHRDIKCENLLLDEN-WNLKLIDFGFARKDTRT SSTK_Mmus GRIPGSQARELFSQIAGAVRYLHDHHLVHRDLKCENVLLSPDERRVKITDFGFGRQAH-- TSSK1_Mmus GALQEDDARKKFHQLSSAIKYCHDLDVVHRDLKCENLLLDKD-FNIKLSDFGFSKRCLRD TSSK2_Mmus GALHEDVARKMFRQLSSAVKYCHDLDVVHRDLKCENLLLDKD-FNIKLSDFGFSKRCLRD TSSK3_Mmus GPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQ-G-FNLKLTDFGFAKVLPK- TSSK4_Mmus GACAETLAGKWFSQMALGIAYLHSKGIVHRDLKLENLLLDKR-ENVKISDFGFAKMVPSS TSSK5_Mmus PGLEEEEARRLFWQLVSAVAHCHNVGIVHRDLKCENILLDDQ-GFIKLTDFGFANWVGL- W02B12.12_Cele GGIHEQKAGLFMSQLIRGLQFMHSINIAHRDIKLENIILFD-N-CVKLSDFGFVRKMDE- Y38H8A.4_Cele KTMSEENAKFTFRQFIAALMHLQSYNIVHRDLKCENIFLDKY-ENVKLGDFGFSRILKP- TSSK2_Spur RSLTEEKARAFFRQMVDGIAYLHSLNAVHRDLKCENILLDAS-NTIKISDFGFARYMEP- TSSK4_Spur GAGTEEQTGLWFHQLVDGMDYCHNLGVVHRDLKCENLLLNKH-NMLKITDFGFARSKMKP TSSK6_Spur GAVPEVLARKWSLQTGRALLYMHGMDVVHRDVKCENLLLDRC-NNIKLTDFGFVRSVG-- TSSK3_Spur NALRDSEARTVFSQILSAVEHLHFHGVYHRDLKCENILLDTG-ITAKITDFGFAREWSE- TSSK5_Spur MAVEEDKARQLFRQIVSGVTFCHDRNVVHRDLKCENIILDEN-WNVKISDFGFACRFPSN AqueK086_Aque RTLPEAEAKYLFRQLVLGIQYLHRHNIVHRDLKCENIMLSKD-MEVKIGDFGFSLNLS-- AqueK087_Aque KRLSERTARSFFRDMVSAITATHRKDIVHRDIKCENLLLDAN-YRLKISDFGFARSVQE- : : .: : ***:* :* :: *: **.* TSSK4_Hsap QPVGCSPSYRQVNCFSHLSQTYCGSFAYACPEILR--GLPYNPFLSDTWSMGVILYTLVV TSSK3_Hsap -------------SHRELSQTFCGSTAYAAPEVLQ--GIPHDSKKGDVWSMGVVLYVMLC TSSK2_Hsap S-----------NGRIILSKTFCGSAAYAAPEVLQ--SIPYQPKVYDIWSLGVILYIMVC TSSK1_Hsap D-----------SGRMALSKTFCGSPAYAAPEVLQ--GIPYQPKVYDIWSLGVILYIMVC SSTK_Hsap -------------GYPDLSTTYCGSAAYASPEVLL--GIPYDPKKYDVWSMGVVLYVMVT B0511.4_Cele ---------------GEKSGTFCGSRAYVAPEIFR--GREYSGNAVDVWSTGVILYIMLA CG14305_Dmel D-----------NGREMKSETYCGSAAYAAPEVVC--GRPYDPKLADAWSLGVILFIMMN CG9222_Dmel S-----------DNQVILSKTFCGSYAYASPEILK--GVAYDPFMSDIWACGVVCYAMVF SSTK_Mmus -------------GYPDLSTTYCGSAAYASPEVLL--GIPYDPKKYDVWSLGVVLYVMVT TSSK1_Mmus D-----------SGRLILSKTFCGSAAYAAPEVLQ--GIPYQPKVYDIWSLGVILYIMVC TSSK2_Mmus G-----------SGRIVLSKTFCGSAAYAAPEVLQ--GIPYQPKVYDIWSLGVILYIMVC TSSK3_Mmus -------------SRRELSQTFCGSTAYAAPEVLQ--GIPHDSKKGDVWSMGVVLYVMLC TSSK4_Mmus QPVHSSPSYRQMNSLSHLSQTYCGSFAYACPEILL--GLPYNPFLSDTWSMGVILYTLVV TSSK5_Mmus --------------KNSLLSTFCGSVAYTAPEILM--SKKYNGEQADLWSLGIILHAMVS W02B12.12_Cele ---------------SALSSTFCGSKSYSAPELLR--GIVYNPFLSDVWSLGVVGFVMVT Y38H8A.4_Cele ---------------GEKSGTFCGSRAYVAPEILR--GREYSGNAVDVWSTGVILYIMLV TSSK2_Spur ---------------KDLSKTYCGSAAYAAPEILK--GNMYNGKLYDVWSLGIILYIMVC TSSK4_Spur P----------EPGRTILSETYCGSYAYAPPEILR--GIPYCPMLGDIWSMGVILYTMLY TSSK6_Spur --------------KGSLSKTFCGSAAYAAPEIIR--SVPYCPLKSDVWALGVVIYILVV TSSK3_Spur ---------------AKPCSTFCGSAAYASPEILQ--AIPYDPNWADIWSLGIILYIMVT TSSK5_Spur --------------RCNMLSTFCGSYAYAAPEIMA--GKNYDGKLADVWSLGIILYALVN AqueK086_Aque ---------------TAPSKTPCGSYSYAAPELFQSSGEPYDGRKSDAWSLGVILFAMTC AqueK087_Aque ---------------GSLLETYCGSFAYAAPEIIR--GEPYSGKKSDVWSMGVVLYAMVC * *** :* **:. . : * *: *:: . : TSSK4_Hsap AHLPFDD--TNLKKLLRET--------------QKEVTFPAN--HTISQECKNLILQMLR TSSK3_Hsap ASLPFDD--TDIPKMLWQQ--------------QKGVSFPTH--LSISADCQDLLKRLLE TSSK2_Hsap GSMPYDD--SDIRKMLRIQK-------------EHRVDFPRS--KNLTCECKDLIYRMLQ TSSK1_Hsap GSMPYDD--SNIKKMLRIQK-------------EHRVNFPRS--KHLTGECKDLIYHMLQ SSTK_Hsap GCMPFDD--SDIAGLPRRQ--------------KRGVLYPEG--LELSERCKALIAELLQ B0511.4_Cele GSMPFDD--RDPRKMIERQL-------------AHKIKFPKS--CTSSVFSKALVLEILQ CG14305_Dmel AKMPFDD--SNLTKLLEDQR-------------NRKFAFRRKLQETISAQAKATVSVLLE CG9222_Dmel GRLPYDG--SNVHILLKRI--------------NQSLVFPKS--PSASSECKHMIMHILA SSTK_Mmus GCMPFDD--SDIAGLPRRQ--------------KRGVLYPDG--LELSERCKSLIAELLQ TSSK1_Mmus GSMPYDD--SNIKKMLRIQK-------------EHRVNFPRS--KHLTGECKDLIYRMLQ TSSK2_Mmus GSMPYDD--SDIKKMLRIQK-------------EHRVDFPRS--KNLTGECKDLIYRILQ TSSK3_Mmus ASLPFDD--TDIPKMLWQQ--------------QKGVSFPTH--LGISTECQDLLKRLLE TSSK4_Mmus ARLPFDD--TNLKKLLRET--------------QKEVTFPAN--LTISQECKNLILQLLR TSSK5_Mmus GKLPFKE--HQPHRMLNLI--------------RRGPIFR--PG--LSPECRDLIRGLLQ W02B12.12_Cele NRMPFDE--KKPNNVIVELQRYLMTLIQPRSGRNRQYVIPHS--VFLSTSCISSFESMMA Y38H8A.4_Cele GTMPFDD--RDPTRMIERQL-------------AHKIKFGKT--CTASIHSKALILEILQ TSSK2_Spur GTMPFDD--SNIKRMIKDQM-------------DQRLCFTKR--KELTLLFKDIVLAILQ TSSK4_Spur GRLPYDD--TNHKVLLNQV--------------QRPPGFPTS--QVVHSDCKDLMCRILS TSSK6_Spur GCMPFGDDVKNIKKILHQQ--------------YSGAHFDASKNTAVRDECRDLIRSMLT TSSK3_Spur GRMPYTE--LEIM----------------------------------------------- TSSK5_Spur GRLPFND--QNLNTLMDQT--------------KKKIKFQP----WVSKACIHLIRKLLR AqueK086_Aque GRLPFGD--DSQV--KAQQ--------------KLGLIFPPS--RPLSHDAKDLLRNILS AqueK087_Aque GKLPFKD--GDFKSLLRQI--------------TAGVSFHS----DVSETCRDLILKILV :*: . TSSK4_Hsap Q-ATKRATILDIIKDSWV TSSK3_Hsap PDMILRPSIEEVSWHPWL TSSK2_Hsap PDVSQRLHIDEILSHSWL TSSK1_Hsap PDVNRRLHIDEILSHCWM SSTK_Hsap FSPSARPSAGQVARNCWL B0511.4_Cele PHAPNRPTYKAICESEWL CG14305_Dmel PEAHARWNLREILNCAWL CG9222_Dmel P-VKIRYNIPQVKEDPWY SSTK_Mmus FSPSARPSAGQVARNGWL TSSK1_Mmus PDVNRRLHIDEILNHCWV TSSK2_Mmus PDVNRRLHIDEILSHSWL TSSK3_Mmus PDMILRPSIEEVSWHPWL TSSK4_Mmus Q-STKRATILDVLRDPWM TSSK5_Mmus LHPCERLDLQQVAAHCWM W02B12.12_Cele FDTRNRPTSTDCLALPWI Y38H8A.4_Cele PHAPNRPTYKAICESEWL TSSK2_Spur PNINMRLKVNDILNHPWM TSSK4_Spur P-AKRRINMEEIQHNAWY TSSK6_Spur ISPKARLTLGEVMESEWL TSSK3_Spur -----------------Q TSSK5_Spur QRPLLRLHANEIVHHPWV AqueK086_Aque PKVKDRFDTYDMILHDWT AqueK087_Aque LSPTERLSTSSILSHAWM