CLUSTAL W (1.83) multiple sequence alignment Trio_Hsap YSEVAELGRGRFSVVKKCDQKGTKRAVATKFVNKKLMKRDQVTHELGILQSLQHPLLVGL Trad_Hsap YTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHPQYITL SPEG_Hsap YDIHQEIGRGAFSYLRRIVERSSGLEFAAKFIPSQAKPKASARREARLLARLQHDCVLYF SPEG~b_Hsap YTFLEEKARGRFGVVRACRENATGRTFVAKIVPYAAEGKRRVLQEYEVLRTLHHERIMSL Obscn_Hsap YEVKEEIGRGVFGFVKRVQHKGNKILCAAKFIPLRSRTRAQAYRERDILAALSHPLVTGL Obscn~b_Hsap FAFQTQIQRGRFSVVRQCWEKASGRALAAKIIPYHPKDKTAVLREYEALKGLRHPHLAQL Obscn_Mmus YDVQEEIGRGVFGFVKRVQHKGNKMFCAAKFIPLRSKTRAQAYQERDILATLGHPLVTGL Obscn~b_Mmus FAFQMQIRRGRFSVVRQCREKASGRALAAKIVPYQPEDKTAVLREYEALKRLHHPHLAQL SPEG_Mmus YDIHQEIGRGAFSYLRRVVERSSGLEFAAKFIPSQAKPKASARREARLLARLQHGCVLYF SPEG~b_Mmus YTFLEEKARGRFGVVRSCRENATGRTFVAKIVPYAAEGKRRVLQEYEVLRTLHHERLMSL Trad_Mmus YTELNEIGRGRFSIVKKCIHKATRKDVAVKFVSKKMKKKEQAAHEAALLQHLQHPQYVTL Trio_Mmus YSEVAELGRGRFAVVKKCDQKGTKRAVATKFVNKKLMKRDQVTHELGILQNLQHPLLVSL Trad_Spur FNITREIGRGRFSSTHACTRSQQQRTLAAKFISKRLMDLEQVQHEASMMQPLQHPLICSL : : ** *. : . ..*:: . :* : * * : Trio_Hsap LDTFETPTSYILVLEMADQGRLLDCVVRWGSLTEGKIRAHLGEVLEAVRYLHNCRIAHLD Trad_Hsap HDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIRDIMEALQYLHNCRVAHLD SPEG_Hsap HEAFERRRGLVIVTELCT-EELLERIARKPTVCESEIRAYMRQVLEGIHYLHQSHVLHLD SPEG~b_Hsap HEAYITPRYLVLIAESCGNRELLCGLSDRFRYSEDDVATYMVQLLQGLDYLHGHHVLHLD Obscn_Hsap LDQFETRKTLILILELCSSEELLDRLYRKGVVTEAEVKVYIQQLVEGLHYLHSHGVLHLD Obscn~b_Hsap HAAYLSPRHLVLILELCSGPELLPCLAERASYSESEVKDYLWQMLSATQYLHNQHILHLD Obscn_Mmus LDQFETRKTLILILELCSSEELLDRLFKKGVVTEAEVKVYIQQLVEGLHYLHSHGILHLD Obscn~b_Mmus HAAYLSPRHLVLILELCSGPELLPSLAERESYSESDVKDYLWQMLSATQYLHAQHILHLD SPEG_Mmus HEAFERRRGLVIVTELCT-EELLERMARKPTVCESETRTYMRQVLEGICYLHQSHVLHLD SPEG~b_Mmus HEAYITPRYLVLIAESCGNRELLCGLSDRFRYSEDDVATYVVQLLQGLDYLHGHHVLHLD Trad_Mmus HDTYESPTSYILILELMDDGRLLDYLMNHDELMEEKVAFYIRDIMEALQYLHNCRVAHLD Trio_Mmus LDTFETPTSYVLVLEMADQGRLLDCVVRWGSLTEGKVRAHLGEVLEAVRYLHNCRIAHLD Trad_Spur HATYETHGQYILVLDLIPDGRILEYLVSLSQVTERQVIGFIRQLVQAVNYLHSNGIIHLD : ::: : .:* : * . .: :::.. *** : *** Trio_Hsap LKPENILVDE-SLAKPTIKLADFGDAVQLNTTY--YIHQLLGNPEFAAPEIILGNPVSLT Trad_Hsap IKPENLLIDL-RIPVPRVKLIDLEDAVQISGHF--HIHHLLGNPEFAAPEVIQGIPVSLG SPEG_Hsap VKPENLLVWDGAAGEQQVRICDFGNAQELTPGE--PQYCQYGTPEFVAPEIVNQSPVSGV SPEG~b_Hsap IKPDNLLLAP----DNALKIVDFGSAQPYNPQALRPLGHRTGTLEFMAPEMVKGEPIGSA Obscn_Hsap IKPSNILMVH--PAREDIKICDFGFAQNITPAE--LQFSQYGSPEFVSPEIIQQNPVSEA Obscn~b_Hsap LRSENMIITE----YNLLKVVDLGNAQSLSQEKVLPSDKFKDYLETMAPELLEGQGAVPQ Obscn_Mmus IKPPNILMVH--PAREDIKICDFGFAQKITPSE--PQYSKYGSPEFVSPEIIEQNPVSEG Obscn~b_Mmus LRSENMMVTE----YNLLKVIDLGNAQSLDQEKVPAPENFKDYLETMAPELLEGQGAVPQ SPEG_Mmus VKPENLLVWDGAGGEEQVRICDFGNAQELTPGE--PQYCQYGTPEFVAPEIVNQSPVSGV SPEG~b_Mmus IKPDNLLLAA----DNALKIVDFGSAQPYNPQALKPLGHRTGTLEFMAPEMVKGDPIGSA Trad_Mmus IKPENLLIDL-RIPVPRVKLIDLEDAVQISGHF--HIHHLLGNPEFAAPEVIQGIPVSLG Trio_Mmus LKPENILVDQ-SLAKPTIKLADFGDAVQLNTTY--YIHQLLGNPEFAAPEIILGNPVSLT Trad_Spur IKPENVMMEK-ALGRAQIKLIDFGDAMDLWSSPPPFYHELNANPEFCSPELLGGNEIDYG ::. *::: ::: *: * * :**:: Trio_Hsap SDTWSVGVLTYVLLSGVSPFLDDSVEETCLNICRLDFSFPDDYFKGVSQKAKEFVCFLLQ Trad_Hsap TDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQ SPEG_Hsap TDIWPVGVVAFLCLTGISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLV SPEG~b_Hsap TDIWGAGVLTYIMLSGRSPFYEPDPQETEARIVGGRFDAF-QLYPNTSQSATLFLRKVLS Obscn_Hsap SDIWAMGVISYLSLTCSSPFAGESDRATLLNVLEGRVSWSSPMAAHLSEDAKDFIKATLQ Obscn~b_Hsap TDIWAIGVTAFIMLSAEYPVSSEGARDLQRGLRKGLVRLS-RCYAGLSGGAVAFLRSTLC Obscn_Mmus SDIWAMGVISYLSLTCSSPFAGESDRATLLNVLEGRVSWSSPTAAHLSEDAKDFIKATLQ Obscn~b_Mmus TDIWAIGVTAFIMLSGEYPESSEGTRDLQKGLRKGLIRLS-RCYAGLSGGAVAFLQSSLC SPEG_Mmus TDIWPVGVVAFLCLTGISPFVGENDRTTLMNIRNYNVAFEETTFLSLSREARGFLIKVLV SPEG~b_Mmus TDIWGAGVLTYIMLSGYSPFYEPDPQETEARIVGGRFDAF-QLYPNTSQSATLFLRKVLS Trad_Mmus TDIWSIGVLTYVMLSGVSPFLDESKEETCINVCRVDFSFPHEYFCGVSNAARDFINVILQ Trio_Mmus ADTWSVGVLTYVLLSGVSPFLDDSVEETCLNICRLDFSFPEDYFQGVSQKAKEFVCFLLQ Trad_Spur TDVWSIGALSYVMLSGISPFLDESLEETNMNIIRVDYSFPEEYFKNVSQNAKHFITGLLH :* * *. ::: *: * . . : * * *: * Trio_Hsap EDPAKRPSAALALQEQWL Trad_Hsap EDFRRRPTAATCLQHPWL SPEG_Hsap QD-RLRPTAEETLEHPWF SPEG~b_Hsap VHPWSRPSLQDCLAHPWL Obscn_Hsap RAPQARPSAAQCLSHPWF Obscn~b_Hsap AQPWGRPCASSCLQCPWL Obscn_Mmus RTPRARPSTSQCLAHPWF Obscn~b_Mmus AQPWGRPCASTCLQCGWL SPEG_Mmus QD-RLRPTAEETLEHPWF SPEG~b_Mmus VHPWSRPSLQDCLAHPWL Trad_Mmus EDFRRRPTAATCLQHPWL Trio_Mmus EDPAKRPSAALALQEQWL Trad_Spur ADSSERKTTSECLMNHWF * * *: