CLUSTAL W (1.83) multiple sequence alignment KDR_Hsap LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIG FLT4_Hsap LHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIG FLT1_Hsap LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIG CG3277_Dmel IQIGRMLGEGAFGQVHEATAINLRRMRGTTIVAVKQLKPNPKADEVAEYLAEIEMLKGVG Pvr_Dmel LKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLG KDR_Mmus LKLGKPLGRGAFGQVIEADAFGIDKTATCKTVAVKMLKEGATHSEHRALMSELKILIHIG FLT4_Mmus LHLGRVLGHGAFGKVVEASAFGINKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIG FLT1_Mmus LKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIG VEGFR2_Spur LKLGGVIGKGAFGMVIKAVAVGIDGTENNITVAVKKLKSGATSLEKKALWAELKMLGHIG VEGFR1_Spur ------------------------------------------------------------ KDR_Hsap HHLNVVNLLGACTKP--GGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDY FLT4_Hsap NHLNVVNLLGACTKP--QGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRA FLT1_Hsap HHLNVVNLLGACTKQ--GGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEK CG3277_Dmel THHNVVSFLGCCTIK---PPYLMIMEYVNKGNLLSYLRDAFEY----------------- Pvr_Dmel QHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLSTEA------------------- KDR_Mmus HHLNVVNLLGACTKP--GGPLMVIVEFCKFGNLSTYLRGKRNEFVPYKSKGARFRQGKDY FLT4_Mmus NHLNVVNLLGACTKP--NGPLMVIVEFCKYGNLSNFLRVKRDTFNPYAEKSPEQRRRFRA FLT1_Mmus HHLNVVNLLGACTKQ--GGPLMVIVEYCKYGNLSNYLKSKRDLFCLNKDAALHMELKKES VEGFR2_Spur KHLNVVNFLGACTQ---NGPVLAIVEFCCHGNLLDFLRSKRKYFSETPEGTG-------- VEGFR1_Spur ------------------KDLFVISEFCPFGNLSDYLKTKRKNYVAEPDLLA-------- : * *: **: :* KDR_Hsap V-GAIPVDLKRRLDSITSSQSSASSGFVEEK----SLSD----VEEEEAPEDLY-KDFLT FLT4_Hsap MVELARLD---RRRPGSSD-RVLFARFSKTEG---GARR----ASPDQEAEDLW-LSPLT FLT1_Hsap MEPGLEQGKKPRLDSVTSSESFASSGFQEDK----SLSD----VEEEEDSDGFY-KEPIT CG3277_Dmel ---------------------------------------------------------ILD Pvr_Dmel --------------------------------------------------------MTVT KDR_Mmus V-GELSVDLKRRLDSITSSQSSASSGFVEEK----SLSD----VEEEEASEELY-KDFLT FLT4_Mmus MVEGAKAD---RRRPGSSD-RALFTRFLMGKG---SARR----APLVQEAEDLW-LSPLT FLT1_Mmus LEPGLEQGQKPRLDSVSSS-SVTSSSFPEDR----SVSD----VEGDEDYSEIS-KQPLT VEGFR2_Spur -----SQS---HTG-HSSS-TGASNTFQTSSGSERRMKAVYDQIIPEEVFSPLQ-DDPIN VEGFR1_Spur IACMGPVD---RSS-RGSS-RGGGDGFMGARGG----ST--LEVGDDDVFEYMEKEQPLT : KDR_Hsap LEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARD-IYKDPDYV FLT4_Hsap MEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARD-IYKDPDYV FLT1_Hsap MEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARD-IYKNPDYV CG3277_Dmel NKELHNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSRHGIYT----- Pvr_Dmel TVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARS-MYRGDNYK KDR_Mmus LEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARD-IYKDPDYV FLT4_Mmus MEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDIVKICDFGLARD-IYKDPDYV FLT1_Mmus MEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARD-IYKNPDYV VEGFR2_Spur SQDLLCYSFQVARGMEFLASKNVIHRDLAARNVLVTENYTLKICDFGLAKH-LYDDPDYV VEGFR1_Spur LKDLICYSYQVARGMEFLTSKKCIHRDLAARNVLLAENNIVKICDFGLARD-IYSDPDYV .* :: *:*.** :* .:: * ******:*: .. :**.****:: :* KDR_Hsap RKG-DARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRL FLT4_Hsap RKG-SARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRL FLT1_Hsap RKG-DTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRL CG3277_Dmel NTR-TRKLPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTISND-ELIPFL Pvr_Dmel KSE-NGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKL KDR_Mmus RKG-DARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRL FLT4_Mmus RKG-SARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRL FLT1_Mmus RRG-DTRLPLKWMAPESIFDKVYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRL VEGFR2_Spur ASGKQGRLPIKWMAPESIFDKVFTTYSDVWAYAVFLWEVFSLGGSPYPGIQIDEKFYNKI VEGFR1_Spur TQT-GGRLPIKWMAPESIFDKVFTIYSDVWSFGVFMWECFALGGSPYPGVVVDEEFYNRL :**::*:: *:: :.::: **:*::.:.:** :*. *** : : .: : KDR_Hsap KEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL FLT4_Hsap RDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEIL FLT1_Hsap REGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKL CG3277_Dmel MAGNRLERPEICTPQVYTIMLQCWLEEPEERPTFDALYKVL Pvr_Dmel NDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRF KDR_Mmus KEGTRMRAPDYTTPEMYQTMLDCWHEDPNQRPSFSELVEHL FLT4_Mmus KDGTRMRAPELATPAIRHIMQSCWSGDPKARPAFSDLVEIL FLT1_Mmus KEGMRMRTPEYATPEIYQIMLDCWHKDPKERPRFAELVEKL VEGFR2_Spur KNGYRMNAPDYAPPGVYDTMLECWTPEPEARPSFSIL--AV VEGFR1_Spur KSGYRMYTPDYAPIEIYHVMLDCWHTEPKERPHFSELVHKL * *: *. : * .** :*. ** * * .