CLUSTAL W (1.83) multiple sequence alignment PIK3R4_Hsap FEYDKSLGSTRFFKVARAKH-REGLVVVKVFAIQDPTLPLTSYKQELEELKIR--LNSAQ PIK3R4_Mmus FEYDKSLGSTRFFKVARAKH-REGLVVVKVFAIQDPTLPLTSYKQELEELKIR--LHSAQ CG9746_Dmel IAFSSNMGSTRFFKVAKAKT-DEGQIVVKVFVKHDPTLPLEDHKERLEGIKKTLSLANAV ZK930.1_Cele CDAVENLGSTRFMKVARGRT-HEGVFVYKVFVRQDL-ASLDPFPQRIIDIRKA--LMKSP VPS15_Scer VHYVSQLNSSRFLKTCKALD-PNGEIVIKVFIKPKDQYSLRPFLQRIRAQSFK--LGQLP Vps15_Ddis IVFKKSLGNARFLKTVKAYHSEEGYVVVKIYKKRNTKESLEKYKIMLKEIKDNFNITPSF 15015_Tthe ------------------------------------------------------------ VPS15_Spur ------------------------------------------------------------ CC1G_08691_Ccin IIYEKSLGSSRFLKTVKCKH-RNGYLVIKIFVKPDPGLTLRNYHKRLKNDKESL--VDIA AqueK216_Aque ------------------------------------------------------------ VPS15-1_Smoe ------------------------------------------------------------ VPS15-2_Smoe ------------------------------------------------------------ GK073_Glam YHAENP-------------QT-KQDFILKVFVKLED-IDLSIFKFMLSHYREKINR-CCP PIK3R4_Hsap NCLPFQKASEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHK- PIK3R4_Mmus NCLPFQKAAEKASEKAAMLFRQYVRDNLYDRISTRPFLNNIEKRWIAFQILTAVDQAHK- CG9746_Dmel NCLPFQRVEL--IDKAAYIMREYVKHSLYDRVSTRPFLTVLEKKWITFQILCALNQCHK- ZK930.1_Cele NCCPIKKVLV--KQKYAVMVRAFQKHTLFDRLSTRPFVVEAEKMWYIFLLFKALSQCET- VPS15_Scer HVLNYSKLIE--TNRAGYMIRQHLKNNLYDRLSLRPYLQDIELKFIAFQLLNTLKDIHN- Vps15_Ddis NIMPYQHFIE--TDRSGYLIRQYFHNNLYDRLSTRPFLSMIEKKFIAFQLLKALEQSSF- 15015_Tthe ----------------------------------KPSLSSFEKNWILFQTLIAIYCVHKL VPS15_Spur ------------------------------------------------------------ CC1G_08691_Ccin NVYNYQVFVE--TERAGYIIRQWVASNLYDRISTRPFLTMVEKRWISFQLLNALRDARN- AqueK216_Aque NVLPYQNFWD--SDKAAFLVRQHVQYNLYDRISTRPYLNNIEKKWIVFQLLKALEGCHE- VPS15-1_Smoe -------WHE--TDKAAYLLRQYFFSNLHERLSTRPFLSTIQKKWLAFQLLHAVKQSHD- VPS15-2_Smoe -------WHE--TDKAAYLLRQYFFSNLHERLSTRPFLSTIQKKWLAFQLLHAVKQSHD- GK073_Glam HVLPYMGEYE--SKTHGFLIRPMLYQSLPEFILQNPWLTRGHKVLYSIQMILAVKEMHE- PIK3R4_Hsap SGVRHGDIKTENVMVTSWNWVLLTDFASF-KPTYLPEDNPA-DFNYFFDTSRRRTCYIAP PIK3R4_Mmus SGVRHGDIKTENVMVTSWNWVLLTDFASF-KPTYLPEDNPA-DFNYFFDTSRRRTCYIAP CG9746_Dmel QKICHGDIKLENILITSWNWILLSDFASF-KPTYLPEDNPA-DYTYFFDTSRRRTCYIAP ZK930.1_Cele AGVCHGDLKSQNVLISSTNWLQITDFAPF-KPCFLTHDNPS-SFTFFFDTSRRQSCYIAP VPS15_Scer LNIVHGDIKTENILVTSWNWCILTDFAAFIKPVYLPEDNPG-EFLFYFDTSKRRTCYLAP Vps15_Ddis KGVFHGDIKSENVLVTTSNWVYLSDFACY-KPTFIPEDNPA-DFSFYFDTSGRRTCYIAP 15015_Tthe ENIFHGAIRSSNILLTTSNHAFLTDFANY-KPLYIDEANQIRDLRFFYKTH-ENNSTLAP VPS15_Spur -------------------------------------------------------CYIAP CC1G_08691_Ccin RKVSHGDIKSENILVTSWNWVYLTDFASY-KPTYLPLDDPS-DFSFYFDTSGRRTCYLAP AqueK216_Aque KKVYHGDLKTENVLLTGWGWVFLTDFASF-KPTLLPADNPA-DYTFFFDTSRRRNCYVAP VPS15-1_Smoe RGVCHGDIKCENVLVTSWNWIYLTDFASF-KPTYIPDDNPA-DFSFFFDTGGRRRCYLAP VPS15-2_Smoe RGVCHGDIKCENVLVTSWNWIYLTDFASF-KPTYIPDDNPA-DFSFFFDTGGRRRCYLAP GK073_Glam AGLVHGDIKLSNFLVTHTHSLMLTDFAPF-KPYQVSMSNPV-ALSYYFTD------TIAP :** PIK3R4_Hsap ERFVDGGMFATELEYMRDP---------------------------------------ST PIK3R4_Mmus ERFVDGGMFATELEYMRDP---------------------------------------ST CG9746_Dmel ERFVKTLASDDDGGN-GNMS-------------------------------V----IHTD ZK930.1_Cele ERFISATEYDEKLR---------------------------------------------- VPS15_Scer ERFNSKLYQD-------------------------------------------------- Vps15_Ddis ERFYETNRGAP------------------------------------------------- 15015_Tthe EKFKNNVEQQLIAL---------------------------------------------- VPS15_Spur ERFVEGSSSRPVDSATSETVEGLQVRQDVKGGELTPAMDIFSVGFVEGSSSRPVDNATSE CC1G_08691_Ccin ERFYTQANNPDISA-K-K----------------------------------------SR AqueK216_Aque ERFVHASSYSQSSS---------------------------------------------- VPS15-1_Smoe ERFYDPKTES-------------------------------------------------- VPS15-2_Smoe ERFYDPKTES-------------------------------------------------- GK073_Glam ERIVQADEELD------------------------------------------------- *:: PIK3R4_Hsap PLV-DLNSNQRTRGELKRAMDIFSAGCVIAELFTEGV-PLFDLSQLLAYRNGHFF----- PIK3R4_Mmus PLV-DLNSNQRARGELKRAMDIFSAGCVIAELFTEGV-PLFDLSQLLAYRNGHFF----- CG9746_Dmel SII-R-LAPSYAGNTLLPAMDIFSAGCALLELWTEGT-APFELSQLLAYRRGERDL---- ZK930.1_Cele -----DGQDEWLFGSLTPKMDMFSAGCIVFELLCDR--PPFTYSSLCEYRSM-------- VPS15_Scer --------GKSNNGRLTKEMDIFSLGCVIAEIFAEGR-PIFNLSQLFKYKSNSYDV---N Vps15_Ddis -----------SNNELTPKMDIFSLGCVIAELFLDGF-PIFDFSQLLSYRKGEYS----- 15015_Tthe -----D-QIAPKLLKDLQSMDIFSLGCVISDLYFEGDQPLFTYEQVQKFKAKQYT----- VPS15_Spur TVEGLQVRQDVKGGELTPAMDIFSVGCVIAELFTEGN-APFDLSQLLAYCSGAYS----- CC1G_08691_Ccin IAA-MEDTPGKRDGKVTEAMDCFSAGCVIAELFLEGA-PLFTLSQLFKYREGELN----- AqueK216_Aque ----ASDS-FQRNKPLTYEMDIFSLGCVTAELFLDGQ-LI-------------------- VPS15-1_Smoe --------PVSPGGALKPSMDMFSLGCVIAELFLEGQ-ALFDLSQLLGYRKRLYD----- VPS15-2_Smoe --------PVSPGGPLTPSMDMFSLGCVIAELFLEGQ-ALFDLSQLLGYRKRLYD----- GK073_Glam -----------TLLLPTMEADVFSLGSALLELWTSI-K-PFDLPTLFEYRDAKTGNIINY * ** *. :: . PIK3R4_Hsap PEQVL-NKIEDHSIRELVTQMIHRE-PDK-RLEAEDYL------------------K PIK3R4_Mmus PEQVL-NKIEDRSIRDLVTQMINRE-PEK-RLEAEDYL------------------K CG9746_Dmel VEKHL-AGIENERLRNLLASMIDIH-SMN-RKSAEDYLD----------------QE ZK930.1_Cele ---------NDADAGNMLLRLIQDV-PAPYRPLLRLLLNRD-------------PSF VPS15_Scer REFLM-EEMNSTDLRNLVLDMIQLD-PSK-RLSCDELLNKYR-----------GIFF Vps15_Ddis PEPIIRQRIQDPNIQTLILHMIQKD-PDQ-RYTPEKYISKWNTV-FPQYFSFAHQFI 15015_Tthe PESII-KKIQCQKTQQLVHKIIMEENEEN-RIGIEEVLK----------------YF VPS15_Spur PDAVL-EQIEDEHIKDLCKHMLQKD-PSK-RMSAEQYLVKGRGTAF-------PEFF CC1G_08691_Ccin VDTQL-ASIEDEGIRNLIKEMIHLD-PTA-RPTFDSLLHTS-------------RGT AqueK216_Aque --------------------------------------------------------F VPS15-1_Smoe PLPSL-EKISDTGIKNMILQMIHVV-PES-RLSCDDYLET---------------WA VPS15-2_Smoe PLPSL-EKISDTGIKNMILQMIHIV-PES-RLSCDDYLET---------------WA GK073_Glam VLSLL-DHITHEELRGLVHAMINPI-PSQ-RIDLST--------------------L