CLUSTAL W (1.83) multiple sequence alignment Wnk4_Hsap LKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKL--SRAERQRFSEEVEMLKGLQHP Wnk3_Hsap LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKL--TKAEQQRFKEEAEMLKGLQHP C46C2.1_Cele LKFDEELGRGSFKTVFRGLDTETGVAVAWCELQESKL--NKTERQRFREEAEMLKDLQHP CG7177_Dmel FKYDKEVGRGSFKTVYRGLDTLTGVPVAWCELLDKQV--KKSERTRFREEADMLKKLQHP Wnk1_Mmus LKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKL--TKSERQRFKEEAEMLKGLQHP Wnk2_Mmus LKFDIELGRGSFKTVYKGLDTETWVEVAWCELQDRKL--TKLERQRFKEEAEMLKGLQHP Wnk3_Mmus LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKL--TKAEQQRFKEEAEMLKGLQHP Wnk4_Mmus LKFDIEIGRGSFKTVYRGLDTDTTVEVAWCELQTRKL--SRAERQRFSEEVEMLKGLQHP Wnk1_Hsap LKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKL--TKSERQRFKEEAEMLKGLQHP Wnk2_Hsap LKFDIELGRGSFKTVYKGLDTETWVEVAWCELQDRKL--TKLERQRFKEEAEMLKGLQHP 17822_Tthe ------------------------------------------------------------ 8961_Tthe IRFNEELGFGAYKTVYRAYDNDSGCEVAWNVIKLQRL--PLNERKRISEEIQLLKNLHHP WNK_Spur MKYDVAVGQGSFKTVFRGLDTETGVAVAWCELQERKL--SRSERQRFKEEAEMLKGLSHP AqueK219_Aque VKYEQEIGRGSFKTVYKGLDTETGVAVAWCELLEHKF--NKEEQSRFKEEVAILKTLNHP WNK_e_Smoe GRYNEVLGRGAFKTVYKAFDEVDGIEVAWNQVNVQDVLGRPEDLERLYSEVHLLRGLKHK WNK_a_Smoe GRYSEVLGKGAFKAVYRAFDEVDGLEVAWNQVNVQDLLRSPDDLERLYSEVHLLKTLKHK WNK_d_Smoe GRYNEILGKGAFKTVYRAFDEVDGIEVAWNQVKVEDVLQSPEDLERLYSEVHLLKSLKHK WNK_c_Smoe GRYNEILGKGAFKTVYRAFDEVDGIEVAWNQVKVEDVLQSPEDLERLYSEVHLLKSLKHK WNK_b-2_Smoe GRYKELLGKGAFKTVYKAFDEIDGIEVAWNQVKLHDVLRSPEDLERLYSEVHLLKSLKHK WNK_b-1_Smoe GRYKELLGKGAFKTVYKAFDEIDGIEVAWNQVKLHDVLRSPEDLERLYSEVHLLKSLKHK GK075_Glam --SGDVLGKGAFKTVYRAFDLIAGREVAWNEVVLDTL--EPMASSKLFQEIKALKDVDHE Wnk4_Hsap NIVRFYDSWKSVL--RGQVCIVLVTELMTSGTLKTYLRRFR-EMKPRV-LQRWSRQILRG Wnk3_Hsap NIVRFYDSWESIL--KGKKCIVLVTELMTSGTLKTYLKRFK-VMKPKV-LRSWCRQILKG C46C2.1_Cele NIVRFYDYWESADLCGKRKYIVLVTELMTSGTLKMYLKRFK-RINIKVVLKSWCRQILKG CG7177_Dmel NIVRFYTYWEFPI--GRKKNIVLVTELMLSGTLKSYLKRFK-KIHPKV-LKSWCRQILKG Wnk1_Mmus NIVRFYDSWESTV--KGKKCIVLVTELMTSGTLKTYLKRFK-VMKIKV-LRSWCRQILKG Wnk2_Mmus NIVRFYDFWESSA--KGKRCIVLVTELMTSGTLKTYLKRFK-VMKPKV-LRSWCRQILKG Wnk3_Mmus NIVRFYDSWESTL--KGKKCIVLVTELMTSGTLKTYLKRFK-VMKPKV-LRSWCRQILKG Wnk4_Mmus NIVRFYDSWKSVL--RGQVCIVLVTELMTSGTLKTYLRRFR-EMKPRV-LQRWSRQILRG Wnk1_Hsap NIVRFYDSWESTV--KGKKCIVLVTELMTSGTLKTYLKRFK-VMKIKV-LRSWCRQILKG Wnk2_Hsap NIVRFYDFWESSA--KGKRCIVLVTELMTSGTLKTYLKRFK-VMKPKV-LRSWCRQILKG 17822_Tthe -------------------------QCLSGGSLK----KIK-KPRLKI-IKQWCKQILSG 8961_Tthe NIINFINAWINK----SKNEVIFITECVSGGSLKKHLKKIK-KPRLKI-IKNWCRQILKG WNK_Spur NIVSFYDYWEEVSP-RGKKHIVLVTELMTSGTLKTYLKRFK-GVKNRV-LRSWCRQILKG AqueK219_Aque YILRLFDSWEFVRQSDKKRVLVLITELMTSGTLKSYMRRFK-SIKPRV-IRSWGRQILRG WNK_e_Smoe NVIKFFTSWVDPR----TKNVNFITEIFTSGTLRQYRKKHK-NVDMKA-VKNWARQILRG WNK_a_Smoe NIIKFYTSWVDSK----RRNVNFITEIFTSGTLRQYRKKHK-NVDMKA-VKNWARQILRG WNK_d_Smoe NIIKLYNSWVDTK----TKNVNFITEIFTSGTLRQYRKKHK-HVDMRA-VKNWAKQILRG WNK_c_Smoe NIIKLYNSWVDTK----TKNVNFITEIFTSGTLRQYRKKHK-HVDMRA-VKNWAKQILRG WNK_b-2_Smoe NIIKFYNSWVDTK----NNNVNFITEIFTSGNLRQYRRKHK-HVDLKA-VKHWARQILRG WNK_b-1_Smoe NIIKFYNSWVDTT----SNNVNFITEIFTSGNLRQYRRKHK-HVDLKA-VKHWARQILRG GK075_Glam NIIKLYDHWFE-----GSNLLIFTTELMPSGCLKKYLKKNPTALTTPV-LKSWALQILEA : . .* *: : :: * *** . Wnk4_Hsap LHFLHSRVP-PILHRDLKCDNVFITGPTGSVKIGDLGLATL-KRASFAKSVIGTPEFMAP Wnk3_Hsap LQFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGDLGLATL-MRTSFAKSVIGTPEFMAP C46C2.1_Cele LSFLHTRNP-PVIHRDLKCDNIFITGTTGSVKIGDLGLATL-KNKSFAKSVIGTPEFMAP CG7177_Dmel LNFLHTRQF-PIIHRDLKCDNIFITGTTGSVKIGDLGLATL-KNRSHAKSVIGTPEFMAP Wnk1_Mmus LQFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGDLGLATL-KRASFAKSVIGTPEFMAP Wnk2_Mmus LLFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGDLGLATL-KRASFAKSVIGTPEFMAP Wnk3_Mmus LQFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGDLGLATL-MRTSFAKSVIGTPEFMAP Wnk4_Mmus LHFLHSRVP-PILHRDLKCDNVFITGPSGSVKIGDLGLATL-KRASFAKSVIGTPEFMAP Wnk1_Hsap LQFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGDLGLATL-KRASFAKSVIGTPEFMAP Wnk2_Hsap LLFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGDLGLATL-KRASFAKSVIGTPEFMAP 17822_Tthe LQYLHEQEPHPIIHRDIKCENIFVNTVNNEIRIGDLGLALT-LKSDFTTSVLGTPEFMAP 8961_Tthe LVYLHEQKPYPIIHRDIKCENVFISTTNNEIRIGDLGLAVSLKNSSHTKSVIGTPEFMAP WNK_Spur LHFLHTRQP-PIIHRDLKCDNIFITGTSGAVKIGDLGLATL-KKSSFAKSVIGTPEFMAP AqueK219_Aque LSFLHTRTP-PIIHRDLKCDNVFINGTTGLVKIGDLGLATL-KRS-DVKTVIGTPEFMAP WNK_e_Smoe LLYLHSHDP-PIIHRDLKCDNIFVNGNQGEVKIGDLGLATILRQAHAAHSVIGTPEFMAP WNK_a_Smoe LLYLHSHDP-PIIHRDLKCDNIFVNGNYGEVKIGDLGLATILRQAHAAHSVIGTPEFMAP WNK_d_Smoe LLYLHSHNP-PIIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRQAHAAHSVIGTPEFMAP WNK_c_Smoe LLYLHSHNP-PIIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRQAHAAHSVIGTPEFMAP WNK_b-2_Smoe LLYLHSHDP-PIIHRDLKCDNIFVNGNHGEVKIGDLGLAGILRQAHGAHSVIGTPEFMAP WNK_b-1_Smoe LLYLHSHDP-PIIHRDLKCDNIFVNGNHGEVKIGDLGLAGILRQAHGAHSVIGTPEFMAP GK075_Glam LNYMHTCQP-KIIHRDIKAQNIFINGATGVVKVGDLGLCASLGLQSTAVSCIGTPEFMAP * ::* ::***:*.:*:*:. . :::*****. . : :******** Wnk4_Hsap EMYE-EKYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGRKPNSFHKV--KI Wnk3_Hsap EMYE-EHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKV--TD C46C2.1_Cele EMYE-EMYDESVDVYAFGMCLLEMVTGEYPYSECMNPATIYRKVISGVKPECFSRIPAQY CG7177_Dmel EMYE-EHYDESVDVYAFGMCMLEMAISEYPYSECKGPAQIYKKVISGIKPAALAKV--ED Wnk1_Mmus EMYE-EKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKV--AI Wnk2_Mmus EMYE-EHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTCGIKPASFEKV--HD Wnk3_Mmus EMYE-EHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKV--TD Wnk4_Mmus EMYE-EKYDEAVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGTKPNSFYKV--KM Wnk1_Hsap EMYE-EKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKV--AI Wnk2_Hsap EMYE-EHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTCGIKPASFEKV--HD 17822_Tthe EIYE-EKYGTAVDIYAFGMCLLEMATLQIPYRECTSAAQVYKKVSQGLLPNSLQLI--QN 8961_Tthe EIYE-EKYGTPVDIYSFGMCVLEMATLSTPYKECTSAAQVYKKVSQGILPYQIDLI--QN WNK_Spur EMYE-EHYDEAVDVYAFGMCLLEMATSEYPYAECSNAAQIYRRVTTGVKPQSFEKV--ND AqueK219_Aque EMYD-EVYDESVDVYAFGMCLLEMCTLEYPYQECSNPAQIYKKVTSGVMPNSLNKV--ND WNK_e_Smoe ELYE-EDYNELVDIYAFGMCVLELVTFDYPYSECTNAAQIYKKVSSGIKPAALDKV--KD WNK_a_Smoe ELYE-EEYDELVDIYSFGMCVLEMVTFEYPYSECTNAAQIYKRVTSGKKPAAFEKV--KD WNK_d_Smoe ELYE-EEYNELVDIYSFGMCLLEMVTFEYPYSECTNAAQIYKKVTSGKKPAALDRV--KD WNK_c_Smoe ELYE-EEYNELVDIYSFGMCLLEMVTFEYPYSECTNAAQIYKKVTSGKKPAALDRV--KD WNK_b-2_Smoe ELYE-EDYNELVDIYSFGMCLLEMVTFEYPYSECMNAAQIYKKVTSGKKPAALNKV--QD WNK_b-1_Smoe ELYE-EDYNELVDIYSFGMCLLEMVTFEYPYSECMNAAQIYKKVTSGKKPAALNKV--QD GK075_Glam ETYSNAHYDEKVDIYAFGMLLLELITRDTPYLECANIVDVLKKVEGNIPPNGLNKV--VH * *. *. **:*:*** :**: . ** ** . . : ::* . * : : Wnk4_Hsap PEVKEIIEGCIRTDKNERFTIQDLLAHAFF Wnk3_Hsap PEVKEIIEGCIRQNKSERLSIRDLLNHAFF C46C2.1_Cele PEIREIIDRCIRVRREERSTVKQLLVDDFF CG7177_Dmel PNVRDIIERCIELKKEDRPSCNELLESEFF Wnk1_Mmus PEVKEIIEGCIRQNKDERYSIKDLLNHAFF Wnk2_Mmus PEIKEIIGECICKNKEERYEIKDLLSHAFF Wnk3_Mmus PEVKEIIEGCIRQNKSERLSIKDLLNHAFF Wnk4_Mmus PEVKEIIEGCIRTDKNERFTIQDLLAHAFF Wnk1_Hsap PEVKEIIEGCIRQNKDERYSIKDLLNHAFF Wnk2_Hsap PEIKEIIGECICKNKEERYEIKDLLSHAFF 17822_Tthe DSLKQFILKCIQRS-ENRPSAAQLLQDDFF 8961_Tthe EGLKNLILKCLSHY-KDRPSAEELLNDKFL WNK_Spur NKIKEIIDGCTKTNNTERYLIQELLKHTFF AqueK219_Aque PMLKEIIVACTKLSKSARYTVEMLLNHEFF WNK_e_Smoe PEVRSFIQKCLATA-SKRLPARELLKDPFL WNK_a_Smoe PEVRKFIEKCLAAV-SRRLPARELLMDPFL WNK_d_Smoe LEVRAFIEKCLATV-SKRLPARELLMDPFL WNK_c_Smoe LEVRAFIEKCLATV-SKRLPARELLMDPFL WNK_b-2_Smoe PQMRAFVEQCLAKA-CRRLPARELLMDPFL WNK_b-1_Smoe PQMRAFVEQCLAKA-CRRLPARELLMDPFL GK075_Glam KEMKDLILLCINKDPSARPSARELLSKPFL :: :: * * ** *: