CLUSTAL W (1.83) multiple sequence alignment VACAMKL_Hsap MPFGCVTLG--------------------------------------------------- PRR1_Scer MDEYSSIYSQPKTPRL-------------------------------------------- MEK1_Scer MRPLYSCNLATK------------------------------------------------ VACAMKL_Mmus MPFGCVTLG--------------------------------------------------- YKL171W_Scer MFTSQRQLRQNGSP--------MSSSRSSQHSSGTASPISDSPASNRSYGRDLRGLMGID YMR291W_Scer MTTASSSASQLQQR---------------------------------------------- 5683_Tthe MGNCTHKPN-INK----------------------------------------------- CC1G_13697_Ccin MS---------------------------------------------------------- CC1G_07362_Ccin MLQYPVQVPSLSLS--------SSAKLASK-----------------PSKDNIPYLLSND CC1G_09141_Ccin MSTSSASTRSTSSS--------FSSTFSDVDDP-MFSPPSSPPASSKTHAFFASSFAASP CC1G_07180_Ccin MEHFESNYVSIGRIQPQ-----AWSTFANF-----------------FPHGDAPHLATSP AqueK053_Aque MAGHLHSPR-NR------------------------------------------------ GK018_Glam MPDGAVVTGSVRHRKIQAIRAIKAMDL---------------TASNA----TIEELAKNI * VACAMKL_Hsap -----------------------------------------------------DK----- PRR1_Scer ------------------------------------------------------------ MEK1_Scer ------------------------------------------------------------ VACAMKL_Mmus -----------------------------------------------------DK----- YKL171W_Scer IPANEP-AFNRANSS----------DTIYFRPK---KIYKMEHEHP-SRSTLVQL----- YMR291W_Scer ------------------------------------------------------------ 5683_Tthe ------------------------------------------------------------ CC1G_13697_Ccin ------------------------------------------------------------ CC1G_07362_Ccin PPR-QPQP------LSSLRFQKDPYAARPVGPN---RL------PA-PIVPLSISTN--- CC1G_09141_Ccin --------------------------------------------PP-PRPPLSLK----- CC1G_07180_Ccin L-------------------------------------------------PVNESHG--- AqueK053_Aque ------------------------------------------------------------ GK018_Glam AKR-FPNL------WTEEKIVQLML------DARENKL------PETEEVPTSLTSTPVQ VACAMKL_Hsap ----------KNYNQPSEVT---------------------------------------- PRR1_Scer ----------KQEGFPDSIGDQ----------HEKALIDENGEEDKKMASTEGTTGD--- MEK1_Scer ----------DDIEMAGGVAPA-------------------------------------- VACAMKL_Mmus ----------KNYNQPSEVT---------------------------------------- YKL171W_Scer ----------QTRSQPDDVASSQVNPEGGTDDLEL--------------------GDPCG YMR291W_Scer -------L-------PE------------------------------------------- 5683_Tthe ----------KNLKLQTK---YQ--------------VNNKI------------------ CC1G_13697_Ccin ------------------------------------------------------------ CC1G_07362_Ccin ------LVPSPSASSPSTAS----------AK---------------------------- CC1G_09141_Ccin ----------KSDNKPTAVKNR----------DDN--------------------GTNPP CC1G_07180_Ccin ------HFP-----SPQKVGDE----------DVL--------------------GD--- AqueK053_Aque ----------PR------------------------------------------------ GK018_Glam SGQLDQKTPQASRSSPSKI----------------------------------------- VACAMKL_Hsap ------------------------------------------------------------ PRR1_Scer ------------------------------------------------------------ MEK1_Scer ------------------------------------------------------------ VACAMKL_Mmus ------------------------------------------------------------ YKL171W_Scer NQSLYTIGAEYVPDLDFTKLV-------------------------------------NE YMR291W_Scer ------------------------------------------------------------ 5683_Tthe ------------------------------------------------------------ CC1G_13697_Ccin ------------------------------------------------------------ CC1G_07362_Ccin ------------------------------------------------------------ CC1G_09141_Ccin PA-------------ASPGLFSSAKTSRFNVSRIFPSRYARSRRDSAEQQDVQNAFSSNA CC1G_07180_Ccin ------------------------------------------------------------ AqueK053_Aque ------------------------------------------------------------ GK018_Glam ------------------------------------------------------------ VACAMKL_Hsap ------------------------------------------------------------ PRR1_Scer -------------------------SRSTPLTVSIPT--------------------FEN MEK1_Scer -----------------------------HLE---------------------------- VACAMKL_Mmus ------------------------------------------------------------ YKL171W_Scer WQKSTEDLYE-------------FRSSATP------QVQIKDSGKGNYELWSSPDAILTQ YMR291W_Scer ------------------------------------------------------------ 5683_Tthe --KS-------------------------------------------------DSDIFED CC1G_13697_Ccin ------------------------------------------------------------ CC1G_07362_Ccin ------------------------------------------------------------ CC1G_09141_Ccin LRRKPDFLFIDVDGDADPNEIHHIDHRETP------F----------------------- CC1G_07180_Ccin ------------------------------------------------------------ AqueK053_Aque ------------------------------------------------------------ GK018_Glam ---------------------------------------------------------FHQ VACAMKL_Hsap ------------------------------------------------------------ PRR1_Scer VQA-------LPTPMTY-TPLSPGNLSMSPID----QS---------------------- MEK1_Scer ---------------------------------V-NVGGYNT--EQTIPIVK-------- VACAMKL_Mmus ------------------------------------------------------------ YKL171W_Scer NKLRRDSFSQ------------ENSDSLSPEDSI-LSRNLHSKV-KPIPLPRNS------ YMR291W_Scer --------------------------------------------EKPWPQLSG------- 5683_Tthe VTPDRK-----PQNLTI-IPKK-SQFKLKPVK-----Q----NLEEPLPSNI-------- CC1G_13697_Ccin ------------------------------------------------------------ CC1G_07362_Ccin ----------------------------HPRSPYISSRQLSA---SPV--P--------- CC1G_09141_Ccin ----KDVFLSLPTAPSY-HDRAGSDSSLSPPSSI-SSSSSHAEI-R-LPTPPP------- CC1G_07180_Ccin ------------------------------------------------------------ AqueK053_Aque ------------------------------------------------------------ GK018_Glam ETAQKAPF-----TKTAQLPVLGGASAANPV---YSSGSFQANQTPPPPHPADSHDRLYR VACAMKL_Hsap ------------------------------------------------------------ PRR1_Scer -------------------------------SLNIPKRRSHARL--LDDMLSVTQPNQRV MEK1_Scer -----------------------------------HQLVKVGR---N-DKECQLVLTNPS VACAMKL_Mmus ------------------------------------------------------------ YKL171W_Scer -----------------------QQIFTPLSNLEAERRSSYTTS--S-NNNSITQNNKFS YMR291W_Scer ------------------------------------------------------------ 5683_Tthe -----------------------------------------T-K---------------- CC1G_13697_Ccin ------------------------------------------------------------ CC1G_07362_Ccin ------------------------------------------------------------ CC1G_09141_Ccin ------------------------------------PPP-LLTA--S-SNAS---DNEFT CC1G_07180_Ccin ------------------------------SELDKEQRVSAAF---I-DADTIIEDHSPS AqueK053_Aque ------------------------------------------------------------ GK018_Glam NHISLGLELAGLERKYLMLRYDANRMFAPPRALQKQTSAVYSVAHYE-KQHALKQLKE-R VACAMKL_Hsap ------------------------------------------------------------ PRR1_Scer VSELIA---PA------NLSPQR-------------------VVSLP---------TVTE MEK1_Scer ISSV-H---CVFWCVFFDE----DSIPMFYVKDCSLNGTY-LN---GLLLKRDKTYLLKH VACAMKL_Mmus ------------------------------------------------------------ YKL171W_Scer FAKL-K-----------YSLPTQSSAVPASFDSNASSLNFLPTTTLS---------TLSE YMR291W_Scer ------------------------------------------------------------ 5683_Tthe ------------------------------------------------------------ CC1G_13697_Ccin ------------------------------------------------------------ CC1G_07362_Ccin ---F-------------RQQPS-GPAPPSALSQCASSGSYPIE----------------- CC1G_09141_Ccin --P--R---PA------DLEPSI------------AAVQPQELSPLS---------PLSE CC1G_07180_Ccin ISPV-R---PS------VSQPTTLASSPAALFLSA------------------------- AqueK053_Aque ------------------------------------------------------------ GK018_Glam IADL-EGRLKG------RLSPKDRATYTAQY----NAA---AIECRS---------LLTE VACAMKL_Hsap ------------------------------------------------------------ PRR1_Scer EAL----------------------------------V---------------------N MEK1_Scer C------------D-----------VIELSQGSEEND---------------------IK VACAMKL_Mmus ------------------------------------------------------------ YKL171W_Scer -------LQISPNDMMDLIQKLPRNFLNLPYTQRKKVIIEHAPSHDYKAMMSLVKKFMLT YMR291W_Scer ------------------------------------------------------------ 5683_Tthe --------------------------------S--------------------------- CC1G_13697_Ccin ------------------------------------------------------------ CC1G_07362_Ccin -------DVLTPGDIVGEGLVLQNEVLRLVGS---------------------------- CC1G_09141_Ccin DNSIPADTELHPGDVIA------------------------------------------- CC1G_07180_Ccin ------------------------------------------------------------ AqueK053_Aque ------------------------------------------------------------ GK018_Glam L------------DV-----------INLQA-EEDGV---------------------IR VACAMKL_Hsap ------------------------------------------------------------ PRR1_Scer D---------SVDSDNYTKEPYFPESSSSTE-----KCDDD------------IFQ---- MEK1_Scer KTRLVFMI-----------------NDDLQSS----LD--PK------------------ VACAMKL_Mmus ------------------------------------------------------------ YKL171W_Scer SSRSNFSLAGFAN--NASVSQATANDDNINSRNTPNN----SNDTYVNTRPLQRSRHGSI YMR291W_Scer ------------------------SN---------------------------------- 5683_Tthe -------------SE-----------------NQMEK----------------------- CC1G_13697_Ccin ------------------------------------------------------------ CC1G_07362_Ccin ------------------------------------T----------------------- CC1G_09141_Ccin ------------------------------------------------------------ CC1G_07180_Ccin ----------FMG--SK-------------------PE--PE------------------ AqueK053_Aque ------------------------------------T----------------------- GK018_Glam RQVSTYCLSNYYN--NESLPVLFPMNADVTVRN----Y--Q------------TVK---- VACAMKL_Hsap ------------------------------------------DRY-DLGQVIKTEEFCEI PRR1_Scer ------------------------------GFLLDHW--DRPLLW-KKVRPIGSGNFSTV MEK1_Scer -------------------------------LLDQMGFLREVDQWEITNRIVGNGTFGHV VACAMKL_Mmus ------------------------------------------DRY-DLGQVIKTEEFCEI YKL171W_Scer ASQFLSSFSPSMTSIAKMNSNPLSGSAGGSARPDDKG--MEILGH-RLGKIIGFGAWGII YMR291W_Scer --------------------------------ADAQT---FKCKYVTNHNSLGDGNFSVV 5683_Tthe ------------------------------TTSSRQN---IYDNY-KMIKLIGKGSFGKV CC1G_13697_Ccin -------------------------------------------------QCLGTGSFATV CC1G_07362_Ccin ------------------------------NESDAAA---PAKEF-EVVRVLGTGSYAVV CC1G_09141_Ccin ------------------------------DSSFASA---TSPSL-RLLRPLGQGAFSAV CC1G_07180_Ccin ------------------------------PLEDDEG--QKVGSY-TLGKVVGFGAFSTI AqueK053_Aque ------------------------------RIEDDSG---IEVDY-SLGEMLGKGAFGVV GK018_Glam ------------------------------LPPVAST---VRPRY-ILMKKLGSGGFSTV . : : : VACAMKL_Hsap FRA--KDKT--------------------------------------------------- PRR1_Scer LLYELMDQSNPK------------------------------------------------ MEK1_Scer LIT--HNSKERDE----------------------------------------------- VACAMKL_Mmus FRA--KDKT--------------------------------------------------- YKL171W_Scer REC--FDIE--------------------------------------------------- YMR291W_Scer KEC--MNIH--------------------------------------------------- 5683_Tthe RLA--TNVN--------------------------------------------------- CC1G_13697_Ccin HLA--FDPT--------------------------------------------------- CC1G_07362_Ccin YLV--REILSRPP----------------------------------------------- CC1G_09141_Ccin WLA--EDLSSIPLVLSSKRSVRDLKRQASLQSKGSVSRKSSLKSPTSSRGVSRNSSMKRF CC1G_07180_Ccin RTG--VSE---------------------------------------------------- AqueK053_Aque WEA--TSVN--------------------------------------------------- GK018_Glam YKA--MDLS--------------------------------------------------- . VACAMKL_Hsap ------------------------------------------------------------ PRR1_Scer ------------------------------------------------------------ MEK1_Scer ------------------------------------------------------------ VACAMKL_Mmus ------------------------------------------------------------ YKL171W_Scer ------------------------------------------------------------ YMR291W_Scer ------------------------------------------------------------ 5683_Tthe ------------------------------------------------------------ CC1G_13697_Ccin ------------------------------------------------------------ CC1G_07362_Ccin -----------------------------PSEDGHMTTIGSMD----------------- CC1G_09141_Ccin MARVTGTQPSVDSLLLDGHVHHEGRETTWTSPDGHLHPMPPSSMHPSPSPSSSISSLPSP CC1G_07180_Ccin ------------------------------------------------------------ AqueK053_Aque ------------------------------------------------------------ GK018_Glam ------------------------------------------------------------ VACAMKL_Hsap ------------------------TGKLHTCKKFQKRDG----------------RK-VR PRR1_Scer -------------------------LKQVAVKRLKYPEELSNVEQINTSLRYKETLSRLE MEK1_Scer --------------------DVCYHPENYAVKIIKLK----------------------P VACAMKL_Mmus ------------------------TGKLHTCKKFQKRDG----------------RK-VR YKL171W_Scer ------------------------TGVGRVIKIVKFKGH----------------QN-IK YMR291W_Scer ------------------------TKDLYAMKLIKKQTVK-----------------NKI 5683_Tthe -------------------------GKEFAVKSILKADA----------------GE-RY CC1G_13697_Ccin ------------------------HHKQVACKSIRTRRE----------------N-EVR CC1G_07362_Ccin ---------------MDGT-PQLEYGREYAIKLLSKANL----------------DEEAL CC1G_09141_Ccin EVGLGASLSRQSSTSTRRSATSRAEARVVAVKLTPRRPEPNS-P---------LTEERTR CC1G_07180_Ccin ------------------------SGSTVAVKIVRRADLVRT-G----------HAPEER AqueK053_Aque ------------------------SKEKFAIKMVHKDKP----------------GSVSI GK018_Glam ------------------------TAQIVALKISRKETSLEGDEH--------IAETKRW . * VACAMKL_Hsap KAAKNEIGILKMV-------------------KHPNILQLVD----------------VF PRR1_Scer NSLTRELQVLKSL-------------------NHPCIVKLLGI--NN----------PIF MEK1_Scer NKFDKEARILLRL-------------------DHPNIIKVYH----------------TF VACAMKL_Mmus KAAKNEIGILKMV-------------------KHPNILQLVD----------------VF YKL171W_Scer KHVLREVAIWRTL-------------------KHNRILPLLD----------------WK YMR291W_Scer QLIQREFDLLRSISEKIRDMEKKNEHSLDIFEGHHHILQLFD----------------YF 5683_Tthe YLLRRELDIMKKV-------------------DHPNLVKFYE----------------TY CC1G_13697_Ccin -QVLKEVRILMTL-------------------KHPNINEIYD----------------TE CC1G_07362_Ccin AAQMTEVTIHQSLP------------------LHPNIVTLHR----------------TL CC1G_09141_Ccin VGFIREVEVLRHI-------------------SHPNITPLLA----------------HF CC1G_07180_Ccin KRLQHEASIWSSL-------------------SHEHILPLFS----------------AL AqueK053_Aque QLLEREIQVLNHV-------------------DHPHIIKLVE----------------VF GK018_Glam LFLNREAAIYHHL-------------------KHPNIVQLNSDPIFVNSTTGRIVLNPAY * : : * : . VACAMKL_Hsap VTRK---------------EYFIFLELATGREVFDWILDQGYY----------------- PRR1_Scer VTSKKPLCDLIIKTPRALPPCDMIMSYCPAGDLLAAVMARNG----R------------- MEK1_Scer CDRNN--------------HLYIFQDLIPGGDLFSYLAKGDCLT--S------------- VACAMKL_Mmus VTRK---------------EYFIFLELATGREVFDWILDQGYY----------------- YKL171W_Scer LDDNY--------------AMYCLTERINDGTLYDLVISWDEFKRSK-IP---------- YMR291W_Scer ETAD---------------NIVLITQLCQKGDLYEKIVEN----QCL------------- 5683_Tthe HDDK---------------YLHIVMEFVQGKELSQYCQERFEVN-RK------------- CC1G_13697_Ccin EDNG---------------FIHIFLQLCTGGDLFTYISTVNLKADRP--G---------- CC1G_07362_Ccin ETPS---------------FLLLLLEYVPGEDLFYFLEQARDHYEPQPSDFVMYNSRTPP CC1G_09141_Ccin STPT---------------YHVLVLPYLKGGDLLSLVNNDAVWGR--------------- CC1G_07180_Ccin HTSY---------------ADYFVTIYCPAGSLYDILKRDGRPAL--------------- AqueK053_Aque ETPK---------------KVFMVLELCRGGELSDILKEKKSF----------------- GK018_Glam EPYN---------------EIALSMELCEGGDLHDFLALLCRSDKQA------------- : VACAMKL_Hsap --------------SER---DTSNVVRQVLEAVAYLHSL--KIVHRNLKLENLVYYNRL- PRR1_Scer -------------LEAW---LIQRIFTEVVLAVKYLHEN--SIIHRDLKLENILLKYSFD MEK1_Scer -------------MSET---ESLLIVFQILQALNYLHDQ--DIVHRDLKLDNILLCTPE- VACAMKL_Mmus --------------SER---DTSNVVRQVLEAVAYLHSL--KIVHRNLKLENLVYYNRL- YKL171W_Scer -------------FAER-CRLTIFLSLQLLSALKYMHSK--TIVHGDIKLENCLLQKEG- YMR291W_Scer -------------DLET---QVTSYCACLVSVLEFLHSQ--GIVHRDLKAENVLFRLRVN 5683_Tthe -------------FTES---EVAFIVRKLLSALSHMHNL--GIIHRDIKLENIMINESN- CC1G_13697_Ccin -------------LCEA---E--------------------------------------- CC1G_07362_Ccin TPSLLSNLHPSQLLSRTRLRLIASMFSQMCDAVAACHST--QVFHRDIKPENFIVTDGWV CC1G_09141_Ccin -------------LSES---VLRRIWCEICRAVGWMHSV--GIVHRDIKLENVLLTWDGL CC1G_07180_Ccin --------------PQD---DAGMMFRQVVRGLRYLHEV-AGLVHRDIKLENVLVDES-- AqueK053_Aque ------------------------------------------------------------ GK018_Glam -------------RTEH---ELLTILLQIAEALKYLHTLDSPITHNDISLRNILLAEG-- VACAMKL_Hsap -----------------------------K--NSKIVISDFHLAKLENG----------- PRR1_Scer DI-NSFRD-----S-------------PIYCKQNFIELADFGLCKKIENN---------- MEK1_Scer -----------------------------P--CTRIVLADFGIAKDLNSN---------- VACAMKL_Mmus -----------------------------K--NSKIVISDFHLAKLENG----------- YKL171W_Scer -----------------------------KKSDWKVFLCDFGMSCHFDEKH-VY-RN--- YMR291W_Scer ENEKNLQGEHHGDF-------------KYDLLAHDLVLADFGLAAEYNT----------- 5683_Tthe ---------------------------------LDVKILDFGLSRDFSQ----------- CC1G_13697_Ccin ------------------------------------------------------------ CC1G_07362_Ccin M-LANG----------------------RQERKVIVKLTDFGLSTTDID----------- CC1G_09141_Ccin QSYSNLISTELSSTPTESSILSIPRPTVADLPTPIVKLTDFGLSRFIDIGNGE------- CC1G_07180_Ccin ---------------------------------GVCRIGDFGLSVRIGDVDDEDGMDHHH AqueK053_Aque ----------------------------------KENVTDFGLSHMKGL----------- GK018_Glam ---------------------------------GVWKLSDFTLVKPLADK---------- VACAMKL_Hsap ------------------------------------------------------------ PRR1_Scer ------------------------------------------------------------ MEK1_Scer ------------------------------------------------------------ VACAMKL_Mmus ------------------------------------------------------------ YKL171W_Scer ---DTFDENLSSGNSHRKRKSIEQTNLIKYPTTNFLPDDRTNDFDASENLKYQFENRKHQ YMR291W_Scer ------------------------------------------------------------ 5683_Tthe ------------------------------------------------------------ CC1G_13697_Ccin ------------------------------------------------------------ CC1G_07362_Ccin ------------------------------------------------------------ CC1G_09141_Ccin ------------------------------------------------------------ CC1G_07180_Ccin HEHHPI-DGACTGNIHR-------------------------------AVSLSFPSKRHR AqueK053_Aque ------------------------------------------------------------ GK018_Glam ------------------------------------------------------------ VACAMKL_Hsap ------------------------------------------------------------ PRR1_Scer ------------------------------------------------------------ MEK1_Scer ------------------------------------------------------------ VACAMKL_Mmus ------------------------------------------------------------ YKL171W_Scer PFTPKGMVSSSSHSLKHLNQPSSSSSSNLFHKPASQPQPQHRSPFHGRHKTTDFSNL--- YMR291W_Scer -----------------------------------------------------------S 5683_Tthe -----------------------------------------------------------S CC1G_13697_Ccin ------------------------------------------------------------ CC1G_07362_Ccin ------------------------------------------------------------ CC1G_09141_Ccin ----------------------------------------------------------RG CC1G_07180_Ccin AATTLGAAIARHNST---------------------------------------RNRHAG AqueK053_Aque ------------------------------------------------------------ GK018_Glam -----------------------------------------------------------K VACAMKL_Hsap ---LIKEPCGTPEYLAPEVVGRQ------------------------------------- PRR1_Scer --EMCTARCGSEDYVSPEILMGV------------------------------------- MEK1_Scer K-ERMHTVVGTPEYCAPEVGFRANRKAYQ------SFS---------------------- VACAMKL_Mmus ---LIKEPCGTPEYLAPEVVGRQ------------------------------------- YKL171W_Scer EP-EPSKYIGSLPYASPELLRYSDARR-SKSVEMHIYDSPDSSQSEISAASSSSSNLSSL YMR291W_Scer KVNSLKEFVGTISYIAPEIVKCKGVGE-M------TPD---------------------- 5683_Tthe QASILQSIVGTPLYVAPEVINEQ------------------------------------- CC1G_13697_Ccin -------SNGSHPFDND------------------------------------------- CC1G_07362_Ccin ---SSDVDCGSAPYMSYECRNNIAP----------------------------------- CC1G_09141_Ccin QGEMLNTRCGSEAYAAPELVMGGGPR---------------------------------- CC1G_07180_Ccin QS-SHVYQPGSLPYAAPELLLPNTAD---------------------------------- AqueK053_Aque --------PGC------------------------------------------------- GK018_Glam EVQMVTSLAGTKPFTAPEKLLQ-------------------------------------- * VACAMKL_Hsap ---------------------------------RYGRPVDCWAIGVIMYILLSGNPPFYE PRR1_Scer --------------------------------PYDGHLSDTWALGVILYSLFEDRLPFDP MEK1_Scer ----------RAATL---------------EQRGYDSKCDLWSLGVITHIMLTGISPFYG VACAMKL_Mmus ---------------------------------RYGRPVDCWAIGVIMYILLSGNPPFYE YKL171W_Scer SSSTKASAVTNS--GVTTSSPSGSSTDFPCIVSPLGPASDIWALGVMLYTMLVGKLPFNH YMR291W_Scer ----------QV--G---------------KLDKYGCPVDIWALGVLTYFMAFGYTPFDC 5683_Tthe ---------------------------------PYDQKSDSWSMGVLMYYLISGSHPFEA CC1G_13697_Ccin -----------------------------------ATYQSSWADDADSYTSV----PTES CC1G_07362_Ccin --------------------------------TYRPRDADVWSLGIVLINMLYHFNPWTD CC1G_09141_Ccin -------------------------------GVYDGRETDAWACGVVLYALVGRKLPFGE CC1G_07180_Ccin -------------------------------MAPAHPGQDIWALGVMLYALLTGHLPFND AqueK053_Aque --------------------------------------------DDLMSSSLCGRMPFNA GK018_Glam --------------------------------GVFGPASDMYSYGVVAFACFVGNINLFL . VACAMKL_Hsap EVEEDD-------------------YEN-----HDKNL-----FRKILAGD-YEF----- PRR1_Scer PPNAS----------------------ARQ---RSRAT-----SHRIARFD-WR------ MEK1_Scer DGSE-------------------------------RSI-----IQNAKIGK-LNF----- VACAMKL_Mmus EVEEDD-------------------YEN-----HDKNL-----FRKILAGD-YEF----- YKL171W_Scer EFEPR-----------------------------LRSL-----I-KVGEFDRFSLAQVCK YMR291W_Scer TTDD--------------------------------ET-----LECISKCD-YYV----- 5683_Tthe SNI--------------------------------KEL-----FKNICSAN-FNF----- CC1G_13697_Ccin QQCLGS-------------------FSE----HRQARL-----KARIVEEE-VVF----- CC1G_07362_Ccin TAEG--------------------------------ACSSFDLYRR---DP-VNF----- CC1G_09141_Ccin GVGIGMDGGHGTQSHINGERVHPPGYSSRKHAVERRAW-----LMRIAKGE-YEW----- CC1G_07180_Ccin SFEP--------------------------------RL-----QMKILNGT-FEI----- AqueK053_Aque ETAP--------------------------------LL-----EEQIMCGA-LKF----- GK018_Glam APNN---------------------F----AEIPGRGS-----LMDRARAD-LCS----- VACAMKL_Hsap -DSP-Y----------------WDDISQA-A----KDLVT---RLMEVEQ--DQRITAEE PRR1_Scer ----------------------WYRLSDY-KTNVGKQIVE---NTLTR-K--NQRWSINE MEK1_Scer -KLK-Q----------------WDIVSDN-A----KSFVK---DLLQTDV--VKRLNSKQ VACAMKL_Mmus -DSP-Y----------------WDDISQA-A----KDLVT---RLMEVEQ--DQRITAEE YKL171W_Scer FDRKKN----------------EGTIGQG-L----YDTVI---GCLTIDL--DKRWKLKR YMR291W_Scer -DEQ-MMH---------------DPKYEQ-F----WNFVQ---CCFTIDP--AVRRSAKN 5683_Tthe -RSS-A----------------WSGISKS-A----KVLIT---QFLNLDP--KSRISCEE CC1G_13697_Ccin -LHC-P----------------WSNLPQ--A----KALVQ---NLLVHDY--RRRANVFE CC1G_07362_Ccin -FTN-R----------------FPGMTRGVA----EFLASRVFCILEGDESEGRRISAAD CC1G_09141_Ccin -PEV-PSDAAAVEDGDGELVGPRLALSEG-A----KRVVG---RLLVRDP--KKRARIVD CC1G_07180_Ccin -PA---------------------DIGRG-A----ERILQ---GCMERII--TKRWTIAM AqueK053_Aque -KEP-E----------------WISISDG-A----KELVR---GMLNVST--INRMTARQ GK018_Glam -GTC-YV----------------CNPSDR-V----VDLIT---NLLCLDM--NARMTAEQ : * VACAMKL_Hsap -----------------------------------AISHEWISGNA-ASD-----KNIKD PRR1_Scer -----------------------------------IYESP-------------------- MEK1_Scer -----------------------------------GLKHIWIAKHL-SQLER---LYYKK VACAMKL_Mmus -----------------------------------AISHEWISGNA-ASD-----KNIKD YKL171W_Scer -----------------------------------IEEVL-------------------- YMR291W_Scer -----------------------------------LKQHPFIKDYF-ATSNS---LNTKD 5683_Tthe -----------------------------------ALQSDWFSVYL-KNQ-----INYKS CC1G_13697_Ccin -----------------------------------ALDSEWMVSEI-SDLQ--------- CC1G_07362_Ccin FGVWVKDNLVTMLAGHGMQRTLSTSSTQGHPITSIPVSHRPMSRNP-SNA------TAAR CC1G_09141_Ccin -----------------------------------LWEDDWMRGDE-IGL-----GMWEA CC1G_07180_Ccin -----------------------------------VDEVSWGVGWGSAGDNATPDESQED AqueK053_Aque -----------------------------------VLEDSWITGGA-VRK------RI-- GK018_Glam -----------------------------------VCQT--------------------- . VACAMKL_Hsap G---VCA-------------------------------QIEKNF--ARAKW-------KK PRR1_Scer ------------------------------------------------------------ MEK1_Scer I---LCN-------------------------------NEGPKLESINSDW-------K- VACAMKL_Mmus G---VCA-------------------------------QIEKNF--ARAKW-------KK YKL171W_Scer ------------------------------------------------------------ YMR291W_Scer ----------------------------------------TPNF--SFHPT-------IR 5683_Tthe RNMKKCL-------------------------------SKIQNF--I--SF-------QN CC1G_13697_Ccin ------------------------------------------------------------ CC1G_07362_Ccin G---TPA-------------------------------MPTRSL--SRAPSLGPAYEREE CC1G_09141_Ccin ----I---------------------------------Q--------------------- CC1G_07180_Ccin L---LAFHAITSPLSAKSCSESRLDRLTIPESDEDDWQHEEHHF--TRSAI-------EA AqueK053_Aque ------------------------------------------------------------ GK018_Glam ------------------------------------------------------------ VACAMKL_Hsap AVRVT-TLMK-----R--LRAPEQSS------TAAAQ-----SAS-ATDTATPGAAGGAT PRR1_Scer ------------------------------------------------------------ MEK1_Scer ------------------------------------------------------------ VACAMKL_Mmus AVRVT-TLMK-----R--LRAPEQSG------TAATQ-----SA---SDAATPGAAGGAI YKL171W_Scer ------------------------------------------------------------ YMR291W_Scer RVSST-ASMH-----T--LRSPSKSR------KTTTLA-------------YLNMDGGSS 5683_Tthe SFKFK-QEII-----R--LMFNTQTQ------TDEIQ-----KLKIAFETIDT-DDNGYI CC1G_13697_Ccin ------------------------------------------------------------ CC1G_07362_Ccin KSELS-TVIDQDNEDD--VEVPEPSEPILGVEEAGSR-----SAS-TSKRRKRGARKGKG CC1G_09141_Ccin ------------------------------------------------------------ CC1G_07180_Ccin GSRRSSSRAK-----RSQSRAPMSAR------SHSRQCSPHRSAR-SSSRMYSGFSSAAV AqueK053_Aque ------------------------------------------------------------ GK018_Glam ------------------------------------------------------------ VACAMKL_Hsap AAAA-------------------------SGA-----TSAPEGDAARAA----------- PRR1_Scer ------------------------------------------------------------ MEK1_Scer ------------------------------------------------------------ VACAMKL_Mmus AAAAAAA-----------AAGGAASA-SGASA-----TAATEGGAGCAA----------- YKL171W_Scer ------------------------------------------------------------ YMR291W_Scer ETSTA-------------------------FSSKMD---LPDLY---------------- 5683_Tthe SAEE-------------------------------------------------------- CC1G_13697_Ccin ------------------------------------------------------------ CC1G_07362_Ccin AQASSPTSPQDDTIVNLAAASECL-ARELSKQSKVSLPSSPKSTSTSSRKRQPLEPVSMY CC1G_09141_Ccin ------------------------------------------------------------ CC1G_07180_Ccin SRSH-------------------------------------------------------- AqueK053_Aque ------------------------------------------------------DPLMML GK018_Glam ------------------------------------------------------------ VACAMKL_Hsap ----------------------------------------------KSDNVAPADRSATP PRR1_Scer ------------------------------------------------------------ MEK1_Scer ------------------------------------------------------------ VACAMKL_Mmus ----------------------------------------------KSDDIASADRSATP YKL171W_Scer ------------------------------------------------------------ YMR291W_Scer ----------------------------------------------VDRTINSRERSLN- 5683_Tthe ------------------------------------------------------------ CC1G_13697_Ccin ------------------------------------------------------------ CC1G_07362_Ccin AMPTP--LLNSSTPRTATKASTFVTCTPVPPSAPTKKPSRWKLSFGKANASTLANAVERP CC1G_09141_Ccin -----------------------------------------------------LDRNASD CC1G_07180_Ccin ------------------------------------------------------------ AqueK053_Aque ADDSPPPHPHSSSHKTSDTSP---------------------------PTISISDKDTPP GK018_Glam ------------------------------------------------------------ VACAMKL_Hsap -ATDGSATPAT------------------------------------------------- PRR1_Scer ------------------------------------------------------------ MEK1_Scer ------------------------------------------------------------ VACAMKL_Mmus -ATDGSATPAT------------------------------------------------- YKL171W_Scer ------------------------------------------------------------ YMR291W_Scer RIRDTLKKTLS------------------------------------------------- 5683_Tthe --------------------------------------------------------LFKA CC1G_13697_Ccin ------------------------------------------------------------ CC1G_07362_Ccin -ATEEAASPASAEPSQPPPPSTTVNNVTNLIMGLDAPAARPIPPAAGVFDDGASTWARGR CC1G_09141_Ccin RVSDG------------------------------------------------------- CC1G_07180_Ccin -------SPATSPLFENPPSRSRSQS-----------------------------RHRGR AqueK053_Aque -STTGGG--------------------------------------------GGGGDAKGR GK018_Glam ------------------------------------------------------------ VACAMKL_Hsap -------------DGSVTPAT--DGSI------------------------T-------- PRR1_Scer ------------------------------------------------------------ MEK1_Scer ------------------------------------------------------------ VACAMKL_Mmus -------------DGSVTPAT--DGSI------------------------T-------- YKL171W_Scer ------------------------------------------------------------ YMR291W_Scer -------------MTSLKPAG--TFDY------LHANKNGTSLSSSKSGLVK------KN 5683_Tthe T------------QQLNIPITQK--QIYALFQEINCHKINNAFKISQEIDVN------QD CC1G_13697_Ccin ------------------------------------------------------------ CC1G_07362_Ccin R------------PRDASPVRKYGGRS------------------------PRRGLQSPS CC1G_09141_Ccin -----------------------SGEV------------------------K-------- CC1G_07180_Ccin QPNKRCYFASRSPSPSWVPST--PSDI------SHIS----------RLSLR-----EPS AqueK053_Aque L------------NKSPTPVQMKSASL------------------------P-------- GK018_Glam ------------------------------------------------------------ VACAMKL_Hsap -------------------------PATD---G-----------------SVTPATDRS- PRR1_Scer ------------------------------------------------------------ MEK1_Scer ------------------------------------------------------------ VACAMKL_Mmus -------------------------PATD---G-----------------SVTPATDRS- YKL171W_Scer ------------------------------------------------------------ YMR291W_Scer ----S----------TF---VL-D-PKPP---KNSLMNGCF---------STTPESRSNF 5683_Tthe ----ENKQQNYIHYSDFIYASINLSKELD---Q-EKINQLFSHFDKDGDNFISPQ-DLE- CC1G_13697_Ccin ------------------------------------------------------------ CC1G_07362_Ccin QPSLA----------DS---WV-D-PPSRGPSR-----------------AISPSSTRS- CC1G_09141_Ccin -------------------------PATN---E-------------------NPITVLK- CC1G_07180_Ccin ----E----------DL---HL-D-SPPRGRTR--------------------------- AqueK053_Aque -------------------------RSTS---A-----------------NRMPLMTSK- GK018_Glam ------------------------------------------------------------ VACAMKL_Hsap ATP---------------------ATDGRATP-ATEESTVPTTQSSAML-------ATKA PRR1_Scer ------------------------------------------------------------ MEK1_Scer ----------------------------RKLP---------------------------- VACAMKL_Mmus ATP---------------------ATDGRATP-ATEESTVPATQSSALP-------AAKA YKL171W_Scer ------------------------------------------------------------ YMR291W_Scer NTP---------------------KTLSRQGS-STSVKKYV--------------NEVDL 5683_Tthe DTF---------------------AQEGRKLP-EQ------------------------- CC1G_13697_Ccin ------------------------------------------------------------ CC1G_07362_Ccin GRPIRSSASSMASSNWR-SSMSTTSSAGTSTSAFTH-YSNGSTRSISTT-------ATSV CC1G_09141_Ccin EDG---------------------LDDGEWEP-LDEDEYLEEED---------------- CC1G_07180_Ccin --------FSLHHETFDEGDEATEGVEGGGALKLTH-AADGTGQCSATDWTSRITAEAED AqueK053_Aque ---------------------KTGGAMGGASSGPTHKKTVSSSISTGRL----------- GK018_Glam ------------------------------------------------------------ VACAMKL_Hsap AAT------PEPAMAQPDS-------------------------------TA-------P PRR1_Scer ------------------------------------------------------------ MEK1_Scer ------------------------------------------------------------ VACAMKL_Mmus AAT------PEPAVAQPDS-------------------------------TA-------L YKL171W_Scer ------------------------------------------------------------ YMR291W_Scer LLT-PRT----ASMSSNDT-------------------------------TA-IND---- 5683_Tthe ------------------------------------------------------------ CC1G_13697_Ccin ------------------------------------------------------------ CC1G_07362_Ccin SATSWRTSVKQPSISSNSSGYSASGGYTSVPKNIKLMNGVPWELDQLPRGQH-------P CC1G_09141_Ccin ------------------------------------------------------------ CC1G_07180_Ccin HVS------PERASSRPNI-------------------------------RSSWTEIPFR AqueK053_Aque ------------------------------------------------------------ GK018_Glam ------------------------------------------------------------ VACAMKL_Hsap EGATGQAPPSSK------------------------------------------------ PRR1_Scer ------------------------------------------------------------ MEK1_Scer ------------------------------------------------------------ VACAMKL_Mmus EGATGQAPPSSK------------------------------------------------ YKL171W_Scer ------------------------------------------------------------ YMR291W_Scer YDTTNDKNPARK------------------------------------------------ 5683_Tthe --SIRQMIEEVD---VDGD-------------G--------------------------- CC1G_13697_Ccin ------------------------------------------------------------ CC1G_07362_Ccin DPSFGNPPPRKQRTRKHKDIK----------------LDTITERPSNSAGLKSPELRKDA CC1G_09141_Ccin ---------------EH-------------------------------EGWL-------- CC1G_07180_Ccin NSRPGSTPPASSKT-----WELFRNKASHGLLSRNPSQ-------DMCLGFPSPGLG--- AqueK053_Aque ------------------------------------------------------------ GK018_Glam ------------------------------------------------------------ VACAMKL_Hsap ----------------------G-------EEA-AGYAQ---ESQREEAS PRR1_Scer ----------------------------------F-VKT---IADTLSFS MEK1_Scer -------------------------------KS-VIISQ-AIPKKKKVLE VACAMKL_Mmus ----------------------G-------EEA-TGCAQ---ESQRVETS YKL171W_Scer ------------------------------QNE-MNLSE---AIHDNNGS YMR291W_Scer ----------------------H--A-ASFQVN-V-DDS---DGDETMQI 5683_Tthe -----------KI-------SQQ-EFLQLVQQE-IEIFQKTRTSFTNLEI CC1G_13697_Ccin ------------------------------------LLY---RRKILGNK CC1G_07362_Ccin MTSTSDLPAVVNAARDEGDNVGSGGVKKVHKGQ-INALA---KMLSALRR CC1G_09141_Ccin -----------L-------------------DE-Q-SIS---SIVRQEVV CC1G_07180_Ccin ------TPGIISR---------SRSIDQYHDPTRTAKVE---IPPASSCA AqueK053_Aque -----------QSTRGRGGGGGGGGAG--------GGAN---SRKLSARN GK018_Glam ------------------------------LSE-M-LSG---YRKTKIKI