CLUSTAL W (1.83) multiple sequence alignment CaMKII_Dmel MAA---------PAACTRFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLT CaMK2g_Mmus MAT---------TATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLS CaMK2d_Mmus MAS---------TTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLS CaMK2b_Mmus MAT---------TVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLS CaMK2a_Mmus MAT----------ITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLS CaMK2a_Hsap MAT----------ITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLS CaMK2b_Hsap MAT---------TVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLS CaMK2d_Hsap MAS---------TTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLS CaMK2g_Hsap MAT---------TATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLS unc-43_Cele MMN-----------ASTKFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLS CAMK2_Spur ------------------------------------------------------------ AqueK055_Aque MTG---------IKEDKAFSEQFEVKEDLGKGAFSIVRKVVHTSSGVDYAAKIINTKRLS AqueK056_Aque MWIKIAFMGVVCPGKEKIFSELYDLKEDLGKGAFSIVKKCIGREDKIEYAAKIINKKRLT CaMKII_Dmel ARDFQKLEREARICRKLHHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEA CaMK2g_Mmus ARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEA CaMK2d_Mmus ARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEA CaMK2b_Mmus ARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEA CaMK2a_Mmus ARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEA CaMK2a_Hsap ARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEA CaMK2b_Hsap ARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEA CaMK2d_Hsap ARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEA CaMK2g_Hsap ARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEA unc-43_Cele ARDFQKLEREARICRKLQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAREFYSEA CAMK2_Spur --------------------NVVRLHDSIAEEGFHYLVFDLVTGGELFEDIVAREYYSEA AqueK055_Aque ARDLQKLEREVKICRMLQHNNIVRLHNVFQEGHVRYMIFDLITGGELFDDIVAREFYSEK AqueK056_Aque GRDISKLQKEEKICRQLQHPNIVLLHDVISESFTHYLVFELITGGELFDEIVAREYYSES *:* **: : * :*::*:*:******::*****:*** CaMKII_Dmel DASHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQG-DHQA CaMK2g_Mmus DASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQG-EQQA CaMK2d_Mmus DASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQG-DQQA CaMK2b_Mmus DASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQG-DQQA CaMK2a_Mmus DASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEG-EQQA CaMK2a_Hsap DASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEG-EQQA CaMK2b_Hsap DASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQG-DQQA CaMK2d_Hsap DASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQG-DQQA CaMK2g_Hsap DASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQG-EQQA unc-43_Cele DASHCIQQILESIAYCHSNGIVHRDLKPENLLLASKAKGAAVKLADFGLAIEVN--DSEA CAMK2_Spur DASHCIQQILESVEHCHKNLIVHRDLKPENLLLASKLKGAAVKLADFGLAIELDN-GE-Q AqueK055_Aque DASSCIQQILDSVSYCHKMGIIHRDIKPENLLLSSKKPGASVKLADFGLAVETEK--KKH AqueK056_Aque DASHCVQQILDGIAYCHRMGIMHRDLKPENLLLASRAKNAAVKLADFGLAVQLETPDQVE *** *::***:.: : * ::***:*******:*: .*:*********:: : CaMKII_Dmel WFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGA CaMK2g_Mmus WFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGA CaMK2d_Mmus WFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGA CaMK2b_Mmus WFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGA CaMK2a_Mmus WFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGA CaMK2a_Hsap WFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGA CaMK2b_Hsap WFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGA CaMK2d_Hsap WFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGA CaMK2g_Hsap WFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGA unc-43_Cele WHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGA CAMK2_Spur WYGFAGTPGYLSPEVLRKDPYGKPVDIWACGLFLFIKFVGFPCLWCEDQQLLYHQAITGL AqueK055_Aque YYGFAGTPGYLSPEVLRKEPYDKAVDLWACGVVLYILLVGYPPFWDDDQSKMFEQIKQGR AqueK056_Aque WHGFAGTPGYLSPEVIKREAYGKAVDVWACGVILYILLVGYPPFWDEDQKRLYAQIKMGR :.*************::::.*.*.**:****:.*:* :**:* :* :** :: * * CaMKII_Dmel YDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWICQRERVASVVHRQETVDC CaMK2g_Mmus YDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVEC CaMK2d_Mmus YDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDC CaMK2b_Mmus YDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVEC CaMK2a_Mmus YDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDC CaMK2a_Hsap YDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDC CaMK2b_Hsap YDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVEC CaMK2d_Hsap YDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDC CaMK2g_Hsap YDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVEC unc-43_Cele YDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITADQALKVPWICNRERVASAIHRQDTVDC CAMK2_Spur WQYPSPEWDTVTPEAKNLIDSMLTVNPGKRISACQALKHPWIQNRDRYASAMHRQETVDC AqueK055_Aque YEYLSPEWDSVTDEVKKLIDGMLTMDPDKRITAEQALSHPWIKNRDKVASMMHRQETIAG AqueK056_Aque YSFPSPEWDSVTKEVKELISLMLNANPKKRIKAEEALRNPWICKRTEVASNIHRQATIAG :.: *****:** *.*.**. **. :* ***.* :** **: :* ** :*** *: CaMKII_Dmel LKKFNARRKLKGAILTTMLATRNFSKF--------------------------------- CaMK2g_Mmus LRKFNARRKLKGAILTTMLVSRNFSVGRQSSAPASPAASAAGLA---------------- CaMK2d_Mmus LKKFNARRKLKGAILTTMLATRNFSAA--------------------------------- CaMK2b_Mmus LKKFNARRKLKGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMG-------------- CaMK2a_Mmus LKKFNARRKLKGAILTTMLATRNFSGG--------------------------------- CaMK2a_Hsap LKKFNARRKLKGAILTTMLATRNFSGG--------------------------------- CaMK2b_Hsap LKKFNARRKLKGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMG-------------- CaMK2d_Hsap LKKFNARRKLKGAILTTMLATRNFSAA--------------------------------- CaMK2g_Hsap LRKFNARRKLKGAILTTMLVSRNFSVGRQSSAPASPAASAAGLA---------------- unc-43_Cele LKKFNARRKLKGAILTTMIATRNLSSKRSYRL--TLGAEKLVISMKNIEYWQVLLNKIFA CAMK2_Spur LKKFNARRKLK------------------------------------------------- AqueK055_Aque LKRFNARRKLKAAMHTAMIISRRSSAFIRPT----------------------------- AqueK056_Aque LKRFNARRKLKGAFLTSLIAVRTHNAA--------------------------------- *::******** CaMKII_Dmel -------TGRSMITKKGEG-SQ-------------------------------------- CaMK2g_Mmus -----GQAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQT CaMK2d_Mmus ---------KSLL-KKPDG-VKINNKAN-------------VVTSPKENIP-TPALEPQT CaMK2b_Mmus ----LVEQAKSLLNKKADG-VKPQTNSTK--------N-SSAITSPKGSLP-PAALEPQT CaMK2a_Mmus ---------KSGGNKKNDG-VKKRKSSS-------------SV----------------- CaMK2a_Hsap ---------KSGGNKKSDG-VKKRKSSS-------------SV----------------- CaMK2b_Hsap ----LVEQAKSLLNKKADG-VKPQTNSTK--------N-SAAATSPKGTLP-PAALEPQT CaMK2d_Hsap ---------KSLL-KKPDG-VKINNKAN-------------VVTSPKENIP-TPALEPQT CaMK2g_Hsap -----GQAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQT unc-43_Cele TYKIKMKQCRNLLNKKEQG-PP-------------------------------------- CAMK2_Spur ------------------------------------------------------------ AqueK055_Aque ------------------G-SPS-TSS------------SNLASPPTNP----------- AqueK056_Aque ---------TFALKKKEPE-VKPQSD---------------VVSSTVPEI---------- CaMKII_Dmel ---------VKESTDSSSTTLEDDDIK-A------------------------------- CaMK2g_Mmus TVVHNATDGIKGSTESCNTTTEDEDLK-AAPL-------RTGNGSLVPEGRSPRDRT--- CaMK2d_Mmus TVIHNP-DGNKESTESSNTTIEDEDVK--------------------------------- CaMK2b_Mmus TVIHNPVDGIKESSDSTNTTIEDEDAK-APRVPDVLSLVRRASGAPEAEGPLSCQSPVPI CaMK2a_Mmus --------QLMESSESTNTTIEDEDTK--------------------------------- CaMK2a_Hsap --------QLMESSESTNTTIEDEDTK--------------------------------- CaMK2b_Hsap TVIHNPVDGIKESSDSANTTIEDEDAK-APRVPDILSSVRRGSGAPEAEGPLPCPSPAPF CaMK2d_Hsap TVIHNP-DGNKESTESSNTTIEDEDVK--------------------------------- CaMK2g_Hsap TVVHNATDGIKGSTESCNTTTEDEDLK-AAPL-------RTGNGSSVPEGRSSRDRT--- unc-43_Cele -------STIKESSESSQT-IDDNDSEKGGGQLKHENTVVRADG------ATGIVSS--- CAMK2_Spur ------------------------------------------------------------ AqueK055_Aque ---------------ENLTLIEEADTC-ATPT---------SNATL-------------- AqueK056_Aque ------------------PVAED------------------------------------- CaMKII_Dmel ------------------------------------------------------------ CaMK2g_Mmus ------------------------------------------------------------ CaMK2d_Mmus ------------------------------------------------------------ CaMK2b_Mmus SPLPTPSPRISDILNSVRRGCGTPEAEGPLSVGPPPCLSPGLLGPLPTPSPRISDILNSV CaMK2a_Mmus ------------------------------------------------------------ CaMK2a_Hsap ------------------------------------------------------------ CaMK2b_Hsap SPLPAPSPRISDILNSVRRGSGTPEAEGPLSAGPPPCLSPALLGPLSSPSPRISDILNSV CaMK2d_Hsap ------------------------------------------------------------ CaMK2g_Hsap ------------------------------------------------------------ unc-43_Cele ------------------------------------------------------------ CAMK2_Spur ------------------------------------------------------------ AqueK055_Aque ------------------------------------------------------------ AqueK056_Aque ------------------------------------------------------------ CaMKII_Dmel --------------------------------ARRQEIIKITEQLIEAINSGDFDGYTKI CaMK2g_Mmus ----------------APSAGMQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKI CaMK2d_Mmus --------------------------------ARKQEIIKVTEQLIEAINNGDFEAYTKI CaMK2b_Mmus RRGSGTPEAEGLPPVGPPPCPSPTLPGPLPTPSRKQEIIKTTEQLIEAVNNGDFEAYAKI CaMK2a_Mmus --------------------------------VRKQEIIKVTEQLIEAISNGDFESYTKM CaMK2a_Hsap --------------------------------VRKQEIIKVTEQLIEAISNGDFESYTKM CaMK2b_Hsap RRGSGTPEAEGPSPVGPPPCPSPTIPGPLPTPSRKQEIIKTTEQLIEAVNNGDFEAYAKI CaMK2d_Hsap --------------------------------ARKQEIIKVTEQLIEAINNGDFEAYTKI CaMK2g_Hsap ----------------APSAGMQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKI unc-43_Cele ----------------SN-SSTASKSSSTNLSAQKQDIVRVTQTLLDAISCKDFETYTRL CAMK2_Spur ------------------------------------------------------------ AqueK055_Aque -------------------LPSNPDSNGGQYSPEEKEIIDITQLLLNSIGQKDFADYSKR AqueK056_Aque --------------------------------ETTDEVMKAQQALLMAIRCRDYEAYQKL CaMKII_Dmel CDPHLTAFEPEALGNLVEGIDFHKFYFENVLGKNCKAINTTILNPHVHLLGEEAACIAYV CaMK2g_Mmus CDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYI CaMK2d_Mmus CDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYI CaMK2b_Mmus CDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYI CaMK2a_Mmus CDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYI CaMK2a_Hsap CDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYI CaMK2b_Hsap CDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYI CaMK2d_Hsap CDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYI CaMK2g_Hsap CDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYI unc-43_Cele CDTSMTCFEPEALGNLIEGIEFHRFYFDGN---RKNQVHTTMLNPNVHIIGEDAACVAYV CAMK2_Spur ------------------------------------------------------------ AqueK055_Aque CSEGMTSFEPEACSQMVTGLDFHKFYFDNMK--ANTPTQNNILKPKVHMLSEGVACIAYT AqueK056_Aque CDSQVLSFLSTGGCRLLTGVEHHNFFFANVPPYPAE--NITMIEPHVQFLGDNAAYICYV CaMKII_Dmel RLTQYIDKQGHAHTHQSEETRVWHKRDNKWQNVHFHRSASAKISGATTFDFIPQ------ CaMK2g_Mmus RLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPA---------APL------ CaMK2d_Mmus RLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPT---------VPIKPPCIP CaMK2b_Mmus RLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGAPV---------APL------ CaMK2a_Mmus RITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPS---------VLP------ CaMK2a_Hsap RITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPS---------VLP------ CaMK2b_Hsap RLTQYIDGQGRPRTSQSEETRVWHRRDGKWQNVHFHCSGAPV---------APL------ CaMK2d_Hsap RLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPT---------VPIKPPCIP CaMK2g_Hsap RLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPA---------APL------ unc-43_Cele KLTQFLDRNGEAHTRQSQESRVWSKKQGRWVCVHVHRSTQPSTN--T---TVSE------ CAMK2_Spur ------------------------------------------------------------ AqueK055_Aque RLTQSIDNQGTPYSQVSNETRVWKKLNDEWKCVHFHRSS--------------------- AqueK056_Aque RLSQHVDKTGRAGSSECKETCIWEKKEGQWKCVHIHTS---------------------- CaMKII_Dmel ---------------K CaMK2g_Mmus ---------------Q CaMK2d_Mmus NGKENFSGGTSLWQNI CaMK2b_Mmus ---------------Q CaMK2a_Mmus ---------------H CaMK2a_Hsap ---------------H CaMK2b_Hsap ---------------Q CaMK2d_Hsap NGKENFSGGTSLWQNI CaMK2g_Hsap ---------------Q unc-43_Cele ---------------F CAMK2_Spur ---------------- AqueK055_Aque ---------------Q AqueK056_Aque ---------------S