CLUSTAL W (1.83) multiple sequence alignment Caki_Dmel MTE-----DEIVFDDVYELCEVIGKGPFSIVRRCIHRESNQQFAVKIVDVAKFTASPGLS CASK_Mmus MAD-----DDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLS lin-2_Cele MRELDPDESNLLLDEQLSIRDVIEQGPFSNVYRILHGPSNRKFLLRSINLNLFRQHTGLG CASK_Hsap MAD-----DDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLS CASK_Spur ------------------------------------------------------------ Caki_Dmel TADLKREATICHMLKHPHIVELLETYSSEGMLYMVFEFMEGSDLCFEVVRRAVAGFVYSE CASK_Mmus TEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSE lin-2_Cele FEEIDEEIRICQNLQHPYICRLEKTINSVHYRHIIFENMEGNDICFEIVQRASNGFVFSE CASK_Hsap TEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSE CASK_Spur ------------------------------------------------------------ Caki_Dmel AVACHYMRQILEALRYCHENEILHRDVRPACALLATVDNSAPVKLGGFGSAIQLPGTRET CASK_Mmus AVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGES--G lin-2_Cele YVVSHYTRQLLDALDYCHTRKIVHRDVRPHNLVLASKDTSAPLKLCGFGVAKDLSEIG-G CASK_Hsap AVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGES--G CASK_Spur ---SHYMRQIMEALRYCHDNDIIHRDIKPHCVLLATKENSAPVKLGGFGIAIPLPSS--G .** **:::** *** ..*:***::* :**: :.***:** *** * * Caki_Dmel IETHGRVGCPHYMAPEVVTRRLYGKGCDVWGAGVMLHVLLSGRLPFLGSGVRLQQSVARG CASK_Mmus LVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKG lin-2_Cele SMACGRVGVPQFMAPEIVRKDRVSCSSDIWSSGVVLFLLLAGRLPFSGSTSDIYERIMQT CASK_Hsap LVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKG CASK_Spur LIAGGRIGTPHFMAPEVVRREPYGKPVDIWGCGVMLFILLSGSLPFFGTKDRLFDMITKG : **:* *::****:* : . *:*..**:*.:**:* *** *: : : : : Caki_Dmel RLSFEAPEWKSISANAKDLVMKMLAANPHHRLSITEVLDHPWIRDRDKL-QRTHLADTVE CASK_Mmus KYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVE lin-2_Cele DVDVDGY-MPNISESARNLVRRMLNADPSKRISAKEALNHEWIRDKEHMASRKHMNDVID CASK_Hsap KYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVE CASK_Spur RYNMKPRQWDHISGDAKELIRSMLSVDPRQRITVEEALAHPWLRERDKFAPKVHLLETVE ... ** .*::*: ** :* .*:: *.* * *:::::: : *: :.:: Caki_Dmel ELKRYNARRKLKGAVQAIAGGTNMDPLYATDADMPITGATD------------------- CASK_Mmus QLRKFNARRKLKGAVLAAVSSHKFNSFYGDPPEE-LPDFS-------------------- lin-2_Cele QMRRYNESRKLKSNVLSAVNSGRFDETTPR-QDTPQTAFVDGSSPGGDCCHRGESSSNDA CASK_Hsap QLRKFNARRKLKGAVLAAVSSHKFNSFYGDPPEE-LPDFS-------------------- CASK_Spur ELKKFNARRKLKGAVLAAVASHKFTSFYSDPNTKHITDFAD------------------- :::::* ****. * : . . .: . Caki_Dmel ---EWADEEAGIE----AV-----QRILDCLDDIYSLQDAH-V--DADVLRDM--LRDNR CASK_Mmus -EDPTSS---GLLAAERAV-----SQVLDSLEEIHALTDCSEK--DLDFLHSV--FQDQH lin-2_Cele AEPPADK---DLS----GA-----YKVLGSLDAINSLLDPNSYKPGSTTFQKI--HDDGS CASK_Hsap -EDPTSS---GLLAAERAV-----SQVLDSLEEIHALTDCSEK--DLDFLHSV--FQDQH CASK_Spur -EDPTSSRSRGIQTTERKRSYGANMNVIDSLLLSLAFVS----------MHSIRLFKCN- . .: .::..* :: . ::.: Caki_Dmel LHQFLQLFDRIA-----ATVVTSN--GRAPA-AEAVGRC-RDVLEQLSSTSGGNSLGGKY CASK_Mmus LHTLLDLYDKIN-----T-KSSPQ--IRNPP-SDAVQRA-KEVLEEISCYP------ENN lin-2_Cele VRNLLRLYDKIK-----AL-PCEP--VVTE-V-DTSTLR-KETLNQIDGLLG-----PSP CASK_Hsap LHTLLDLYDKIN-----T-KSSPQ--IRNPP-SDAVQRA-KEVLEEISCYP------ENN CASK_Spur ---IIQALDFMACSSSTV-MSCPMLPLQNVPSLQSVHVTTEQVLELFRQHNQ-----DSQ :: * : . :: .:.*: : . Caki_Dmel AKEELMRLLAAPHMQALLHSHDVVARDVYGEE--------------AARHP-APDGALPQ CASK_Mmus DAKELKRILTQPHFMALLQTHDVVAHEVYSDE--------------ALRVTPPPTSPYLN lin-2_Cele EALELRQLLNSPHLASCVQALDVVVCEIRDPKNEASGSGDKEGNASLFCVSSDPAPAYLN CASK_Hsap DAKELKRILTQPHFMALLQTHDVVAHEVYSDE--------------ALRVTPPPTSPYLN CASK_Spur DAYELQAILSDPYFRALLQAHDVVAHEVYSDH--------------AIRVTPPPVMPYLN ** :* *:: : ::: ***. :: . . . * . : Caki_Dmel WR-----------------------ELDNVEGG-E-LQHVTRVRLVHFQKNTDEPMGITL CASK_Mmus GDS-P----------------------ESANGDMD-MENVTRVRLVQFQKNTDEPMGITL lin-2_Cele GGVLPLGAQRAGTSFEHFNQSAVHTSYDEEEE--ELYDCMSRLRLVQFQKDTQEPMGITL CASK_Hsap GDS-P----------------------ESANGDMD-MENVTRVRLVQFQKNTDEPMGITL CASK_Spur GDS-E--------------------LMQPPNGNMDQTDQVTRVRLVQFQKNSEEPLGITL : : : : ::*:***:***:::**:**** Caki_Dmel KMTEDGRCIVARLMHGGMIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLREARGSVTF CASK_Mmus KMNELNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITF lin-2_Cele KVNEDGRCFVARIMHGGMIHRQATLHVGDEIREINGMSVANRSVESLQEMLRDARGQVTF CASK_Hsap KMNELNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITF CASK_Spur KMNEDRRCIVARIMHGGMIHRQATLHVGDEIREINNASVANQTVDQLQKLLRELKGSITF *:.* :*:***:*********.************. .* :::* .**.:**: :*.:** Caki_Dmel KIVPSYRSAPPPCE-----------------------------------IFVRAQFDYNP CASK_Mmus KIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDP lin-2_Cele KIIPSYRSAPPACE-----------------------------------IFVRAQFDYEP CASK_Hsap KIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDP CASK_Spur KIVPSYRSAPQPCE-----------------------------------IYVRAQFDYDP **:****: . .** *:*****:*:* Caki_Dmel LDDELIPCAQAGISFQVGDILQIISKDDHHWWQARLG-T--------------VGGSAGL CASK_Mmus AKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLEN--------------SKNGTAGL lin-2_Cele SQDDLIPCPQAGIPFKTGDILQVISKDDHNWWQARFVSSFPSIGNSSNAQRSNQQQVAGL CASK_Hsap AKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLEN--------------SKNGTAGL CASK_Spur GQDDLIPCQQAGLSFRCGDILQIISKDDHNWWQARKEGE-------------PLNGTAGL .*:**** :**: *: ***:*:******:***.: *** Caki_Dmel IPSPELQEWRIACQTVDKTKQE-QVNCSIFGRKKKQCRDKYLAKHNAIFDTLDVVTYEEV CASK_Mmus IPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAVFDQLDLVTYEEV lin-2_Cele IPSPELQEWRTACLAMERSKNTCNTHCMWFNKKKKYYTTKYLQKHSALFDQLDLVTYEEV CASK_Hsap IPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAVFDQLDLVTYEEV CASK_Spur IPSPELQEWRVACLAIERAKKEQQASCTWFGRRKKQYRDKYLAKHNAVFDQLDLVTYEEV ********** ** :::::*: :. * *.::** *** **.*:** **:****** Caki_Dmel VKVPVGDPNFQRKTLVLLGAHGVGRRHIKNTLISKYPDKYVYPIPHTTRPAKPEEENGRS CASK_Mmus VKLP----AFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKN lin-2_Cele MRLS----QYRRKTLVLLGAHGVGRRHIKNTLIHRHPNRFAYPIPHTTRPPRKDEVDGKH CASK_Hsap VKLP----AFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKN CASK_Spur VRLP----AFMRKTLVLLGAHGVGRRHIKNTLITSHPNKYAYPIPHTTRRCKSDEENGKN :::. : ********************** :*:::.******** : :* :*: Caki_Dmel YYFVSHDEMMADIGANEYLEYGTHEDAMYGTKLDTIRRIHTEGKMAILDVEPQALKILRT CASK_Mmus YYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRT lin-2_Cele YYFVTNEQMMADIQNNEYLEYGTHEESMYGTKLETIRNIHKSGKIAILDVEPQALKVLRT CASK_Hsap YYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRT CASK_Spur YFFVSHEEMMNDIANNKYLEYGTHEDAMYGTKLDTIREIHNRSLIAILDVEPQALKVLRC *:**::::** ** *:*****:**::******:***.** . :***********:** Caki_Dmel AEFTPYVVFIAAPSLQNIAD-YDGSLERLAKESEMLRQLYGHFFDLTIVNNDISETIATL CASK_Mmus AEFAPFVVFIAAPTITPGLN-EDESLQRLQKESDVLQRTYAHYFDLTIINNEIDETIRHL lin-2_Cele AEYSPFVVFIAAPNLQGMQD-PDGSLEKLLNESDVLRQAFGHLFDFIITNSDIDDTIAQL CASK_Hsap AEFAPFVVFIAAPTITPGLN-EDESLQRLQKESDILQRTYAHYFDLTIINNEIDETIRHL CASK_Spur AEFAPFVVFIAAPTLTGMNDVHDSSLERLAKESELLRQAYGHFFDLTIVNNDIDDTIRTL **::*:*******.: : * **::* :**::*:: :.* **: * *.:*.:** * Caki_Dmel ETAIDRVHTTPQWVPVSWLY CASK_Mmus EEAVELVCTAPQWVPVSWVY lin-2_Cele ERLVEKLPAYPQWLPVTWVY CASK_Hsap EEAVELVCTAPQWVPVSWVY CASK_Spur ENAMEEICTTPQWVPVSWVY * :: : : ***:**:*:*