CLUSTAL W (1.83) multiple sequence alignment otk_Dmel MTARM--------ISICGLVMALMMASVLASSSRFQRVPQS-QSVVE------------- CCK4_Mmus MGARP--------LTLLRALLLPLLAGAQ-AAIVFIKEPSS-QDALQ------------- CCK4_Hsap MGAARGSPARPRRLPLLSVLLLPLLGGTQ-TAIVFIKQPSS-QDALQ------------- CCK4_Spur MLAYVN-----------------------------IAGISEE------------------ AqueK250_Aque MAAFLE---------------------DE-DSVVSIKDIVDEEQALQDTANAVLGDSDDT * * . otk_Dmel ---------NESVKFECESTDSYSEL--------------------HYDW---------- CCK4_Mmus ---------GRRALLRCEV-EAPDPV--------------------HVYW---------- CCK4_Hsap ---------GRRALLRCEV-EAPGPV--------------------HVYW---------- CCK4_Spur ------------------------------------------------------------ AqueK250_Aque NCTYTKGYVSRQALYACST-CTPSSSVLAGFCLACSLRCHEGHDVIELYTKRNFRCDCGN otk_Dmel -------------------------LHNG------------------------------- CCK4_Mmus -------------------------LLNG------------------------------- CCK4_Hsap -------------------------LLDG------------------------------- CCK4_Spur ------------------------------------------------------------ AqueK250_Aque SKISGNPCLLCPDKDPLNSENIYNHNFNGLYCTCNRPYPDLDDEVEDEMIQCSVCEDWYH otk_Dmel ----------------------------------H----------------------RIA CCK4_Mmus ----------------------------------V----------------------PVQ CCK4_Hsap ----------------------------------A----------------------PVQ CCK4_Spur ------------------------------------------------------------ AqueK250_Aque TRHLGLHPPNSFEETVCDKCMSRLSFLYHYKIHSVSSEEPFVHQETLDACTSTTHHIESE otk_Dmel YDK--------------------------------------------------------R CCK4_Mmus DTE--------------------------------------------------------R CCK4_Hsap DTE--------------------------------------------------------R CCK4_Spur ------------------------------------------------------------ AqueK250_Aque KTETHTAKTESDSIIPNGKEAEPKTLSTDSPPLKSDPVPGPTNESQSQLRETETCVLEKR otk_Dmel VHQIGSNLHIEAVRRT-------------------EDVGNYVCIATNLASGAREASPP-- CCK4_Mmus RFAQGSSLSFAAVDRL-------------------QDSGAFQCVARDNVTGEEVRSTN-- CCK4_Hsap RFAQGSSLSFAAVDRL-------------------QDSGTFQCVARDDVTGEEARSAN-- CCK4_Spur ------------------------------------------------------------ AqueK250_Aque KTLSSSSSNFSGPGYFTSQWRSELCSCSSCKKMYKELSVEFLLDTLDSITSYETRAKSTG otk_Dmel -------------------------------------AKLSVIYLESASVQLLG------ CCK4_Mmus -------------------------------------ASFNIKWIEAGPVVLKHPA---- CCK4_Hsap -------------------------------------ASFNIKWIEAGPVVLKHPA---- CCK4_Spur --------------------------------LRV---------------QLNRPN---- AqueK250_Aque YIHDVGMEALSSSMGRVQQVEMINGYNHMKEELKKFLGSFASKGKVVRPRDITDFFGELE : otk_Dmel ---------------------SNRNELLLKCHVEGASGDLEPLEIEWYRNSEKLSTW--- CCK4_Mmus ----------------SEAEIQPQTQVTLRCHIDGHP---RP-TYQWFRDGTPLSDDQST CCK4_Hsap ----------------SEAEIQPQTQVTLRCHIDGHP---RP-TYQWFRDGTPLSDGQSN CCK4_Spur ----------------LPEDVEEGGKVTLICRASGNP---VP-MVTWYHDQTPVVA---G AqueK250_Aque NQKRQSHGGASPPTVVGPPVVIEGDSVSLHCD--TGS---SE-AVQWFKDGVSVSVS--N .: * * . *::: : otk_Dmel KNVQLDQHRLIIRQPG-SEDDGLYRCTASNAAGRVMSKQGYVYQSS---------VKCLP CCK4_Mmus HTVSSRERNLTLRPAS-PEHSGLYSCCAHNAFGQACSSQNFTLSVA---------DESFA CCK4_Hsap HTVSSKERNLTLRPAG-PEHSGLYSCCAHSAFGQACSSQNFTLSIA---------DESFA CCK4_Spur SNVDISGTRLKIKSAT-PLDSGIYSCMATNVAGSMPSTENVQFNIV---------DSNTP AqueK250_Aque PNFDTSESNISISSANATIHSGTYACSLTSNQSEV--STPFQLTVYYFHGKLSICKVREN ... .: : . . ..* * * . . . otk_Dmel RL---------------------------------------------------------- CCK4_Mmus RV---------------------------------------------------------- CCK4_Hsap RV---------------------------------------------------------- CCK4_Spur VV---------------------------------------------------------- AqueK250_Aque NIQVSPVDSMLYPGLSSYSVSVESDVLLTCCTPPAIPPVHNVSWIKVDGNTRPSDGGDSS : otk_Dmel ---------------------------------------------------PRRKNEKMM CCK4_Mmus ---------------------------------------------------VLAPQDVVV CCK4_Hsap ---------------------------------------------------VLAPQDVVV CCK4_Spur ---------------------------------------------------EVAPTDAIR AqueK250_Aque EGWSLLLSDIAVNDRGRYRCSYEHVAAGTVQSEEVELKVAVQGSTPATPVDVTVPQSTVC . : otk_Dmel -ESWDKQTFLCR------------------------------------------------ CCK4_Mmus -ARNEEAMFHCQFSAQPP-PSLQWVFEDETPITNRSRPPHLRR-----AVVFANGSLLLT CCK4_Hsap -ARYEEAMFHCQFSAQPP-PSLQWLFEDETPITNRSRPPHLRR-----ATVFANGSLLLT CCK4_Spur -VLGDSIMFHCQFSGDPT-PPVEWYTTSK---AGGEIPPQLMNDTETGTYIIGNGSLSLA AqueK250_Aque TKPGNTVTIHCTVSGTVGNGDVSWKLGDN---TL---PSNERY-----SVDPVTNSLTIT : : * otk_Dmel ---------------GKRGGAAGLEALP--AAPEDLRIVQG-PIGQSIIKEGEPTALTCL CCK4_Mmus QVRPRNAGVYRCIGQGQRGPPIVLEATLHLAEIEDM-----LPFEPRVFIAGDEERVTCP CCK4_Hsap QVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDM-----PLFEPRVFTAGSEERVTCL CCK4_Spur NLTAGDEGEFQCVCDSPHGRPFA-SARLTIATVNPL-----PEFEAQLIPEGDTKTINCS AqueK250_Aque NAALSDDGVYKCTAINDLNADSA-TVHLNMTCIHSVH--VSPSFVST--GLGTSKTLACS . . . : . : : * : * otk_Dmel YELPDELKNQRIQLRWRKDGKLLRQVELGGS----------------------------- CCK4_Mmus APQ----GLPTPSVWWEHAG--VP-LPAHG------RVHQKGLELVFVTIAESDTGVYTC CCK4_Hsap PPK----GLPEPSVWWEHAG--VR-LPTHG------RVYQKGHELVLANIAESDAGVYTC CCK4_Spur YPAGDVGGIPTPSIHWLKPS--LREVPLDGTKTKRVRVEEQKNLLVFDPIKKSDEGNYTC AqueK250_Aque SNHDD--SLATPTYFWFTPQ--G--------------IEVQGPELVLNNLQYSDAGSYNC * otk_Dmel ------------------------------------------------APIPGHSFDSG- CCK4_Mmus HASNLAGQ-RRQDVNITVATVP--TWLRKPQDSQLEEGKPGYLHCLTQ-ATPKPTVIWYR CCK4_Hsap HAANLAGQ-RRQDVNITVATVP--SWLKKPQDSQLEEGKPGYLDCLTQ-ATPKPTVVWYR CCK4_Spur VSSNMAGE-TTQILKVVVATAP--KITTRPVDVHIREREEATLRCNAT-GTPTPTISWTF AqueK250_Aque TASSPNSLPVSSLVSLTVLGPPLVKITAFP-NREARLYRPLTLHCSVNVSIPDQEIEWSK * . otk_Dmel KDALLREDARLVLHKQNGTLSFASIIASDAGQYQCQLQLEAHAPINSSPGILEVIEQLKF CCK4_Mmus NQMLISEDSRFEVS-KNGTLRINSVEVYDGTLYRCVSSTPAGS-IE-AQARVQVLEKLKF CCK4_Hsap NQMLISEDSRFEVF-KNGTLRINSVEVYDGTWYRCMSSTPAGS-IE-AQARVQVLEKLKF CCK4_Spur GTRDIT------------------------------------------NVRNHVLTILKF AqueK250_Aque ENSTDKNFISSESF-NSNILTIRNFSVSDVGVYHCSYTSDTY--RE-VKNSVHVVLTNKI .*: *: otk_Dmel VPQPTSKN-L-ELDAVVAKVHCKAQG----TPTPQVQWVRDGE------NTTLPDHVEVD CCK4_Mmus TPPPQPQQCM-EFDK-EATVPCSATG----REKPTVKWVRAD-------GSSLPEWVT-D CCK4_Hsap TPPPQPQQCM-EFDK-EATVPCSATG----REKPTIKWERAD-------GSSLPEWVT-D CCK4_Spur NPRPIAVTSL-DRGE-MNRLVCHATA----SIQPFIAWHKQGI------IGTWPDHISEP AqueK250_Aque YPKFDIISRTGIVNE-ILIVTCEFLGGISSDGTLTVSWFKGGSPLRSSRNVTVSNGVVQG * . : * . : * : . : .: : otk_Dmel ANGTLIFRNVNSEHRGNYTCLATNS-QGQINATVAINVVVTPKFSVPPVGPIETSEQGTV CCK4_Mmus NAGTLHFARVTRDDAGNYTCIASNEPQGQIRAHVQLTVAVFITFKVEPERTT-VYQGHTA CCK4_Hsap NAGTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTT-VYQGHTA CCK4_Spur NSGVLQFNPAEASDAGTYICIASTG-LERINTTVRIDVVVKPKFVIIPNNTI-GFEGYSL AqueK250_Aque GVASLTINSVKMSDEGSYSCLASDG-VHEFNETFEIIVNVPGSFLEVPPSSVQYMEGEYL . * : . .. *.* *:*: .:. . : * * .* * . : otk_Dmel VMHCQAIGDPKPTIQWDKDLKYLSENNTDRERFRFLENGTLEIRNVQVEDEGSYGCTIGN CCK4_Mmus LLRCEAQGDPKPLIQWKGKDRILDPTK-LGPRMHIFQNGSLVIHDVAPEDSGSYTCIAGN CCK4_Hsap LLQCEAQGDPKPLIQWKGKDRILDPTK-LGPRMHIFQNGSLVIHDVAPEDSGRYTCIAGN CCK4_Spur KIDCTAHGDPEPTITWISKPIM-------------------------------------- AqueK250_Aque YLECRVAGKPLPKVTWLKELSHLES----DDRIIVDSNGSLVITSIVMSDAGDYLCFFDS : * . *.* * : * . otk_Dmel SAGLKREDVQLVVKTTGDGFAPEESGGDG----FLVTRAVLITMTVALAYIV-LVVGLML CCK4_Mmus SCNIRHTEAPLLVVD---KPVMEDSEGPGSPPPYKMIQTIGLSVGAAVAYII-AVLGLMF CCK4_Hsap SCNIKHTEAPLYVVD---KPVPEESEGPGSPPPYKMIQTIGLSVGAAVAYII-AVLGLMF CCK4_Spur ------------------------------------------------------------ AqueK250_Aque PDGVKEHSTVTIKVS-PRQATPTALTG--DDTILGLEQNLFISIVLAVVGVIFIILIVLL otk_Dmel WC----RYRRQARKARLNDLSTKEAGGDQ----------------PDVAGNGKGSEQ-EP CCK4_Mmus YC----KKRCKAKRLQ------KQPEGEE----------------PEMECLNGGPLQN-- CCK4_Hsap YC----KKRCKAKRLQ------KQPEGEE----------------PEMECLNGGPLQN-- CCK4_Spur ------------------------------------------------------------ AqueK250_Aque LCCTLCYVKCRSRE--------RSTNGHQKAVLETVSFERRPSLRGSLRKDNSGILQQNP otk_Dmel C-LS------KQHNGHSKSRSKSSGDAQK-SDDTACSQQSRASK--------KSAHIY-- CCK4_Mmus --------------------GQPSAEIQEEVALTSLGSGPPATN--------KRHSAG-- CCK4_Hsap --------------------GQPSAEIQEEVALTSLGSGPAATN--------KRHSTS-- CCK4_Spur ------------------------------------------------------------ AqueK250_Aque SDLSSLWTFTTDN-----SNSVPMTAVSSSVAV---SPGPPVPSPIPPPPDGPTASLATE otk_Dmel -----EQLALPRSGLSE-LIQIGRGEFGDVFVGKLKATLVTSPSDKDADTEKQHSNSENG CCK4_Mmus -----DRMHFPRASLQP-ITTLGKSEFGEVFLAKAQGV---------------------- CCK4_Hsap -----DKMHFPRSSLQP-ITTLGKSEFGEVFLAKAQGL---------------------- CCK4_Spur --------NYPEHFTHLP---NGHGAYGEVTLSRAAGI---------------------- AqueK250_Aque LNLPHGISSFPRHKLMLSGDIMGEGEFGPVVKAIARHI---------------------- *. *.. :* * . otk_Dmel SGGSGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHNQSGLEQLVLVKALNKVKDEQA CCK4_Mmus --------------------------------------EEGATETLVLVKSLQS-RDEQQ CCK4_Hsap --------------------------------------EEGVAETLVLVKSLQS-KDEQQ CCK4_Spur --------------------------------------KDGEEATTVMVKALET-KEESL AqueK250_Aque --------------------------------------TEDSSETLVAVKVLMS-REGEE :. * ** * . :: . otk_Dmel C-----QEFRRQLDLLRAISHKGVVRLFGLCREKDPHYMVLEYTDWGDLKQFLLATAGKV CCK4_Mmus Q-----LDFRREVEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKNKD CCK4_Hsap Q-----LDFRRELEMFGKLNHANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKD CCK4_Spur Q-----LDFRREIEMLGKLNHENIVKLLGVCRDTEPQLMITEYLDWGDLKQFLQATRGEN AqueK250_Aque ALWPSLMDFSNQM----RLSSPFISKILGICADAEPYYVIYEYLDRGDLKNFLFASHP-- :* .:: :. : :::*:* : :* :: ** * ****:** : otk_Dmel NTATAGSSSPPPLTTSQVLAVAYQIARGMDAIYRARFTHRDLATRNCVISSEFIVKVSYP CCK4_Mmus E----KLKS-QPLSTKQKVALCSQVALGMEHLSNNRFVHKDLAARNCLISAQRQVKVSAL CCK4_Hsap E----KLKS-QPLSTKQKVALCTQVALGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSAL CCK4_Spur G----TKNVPPPLTLSQKIDIVNQVALGMETLSANRFIHGDLAARNCLLSPSMEVKICTM AqueK250_Aque -----SPHSEPMLTQSDLLHFVSQIAEGMRYLYSQQIIHGDLATRNCLISSNFSVKIADL *: .: : . *:* ** : :: * ***:***::*.. **:. otk_Dmel ALCKDKYSREYHKHRNTLLPIRWLAPECIQED----EYTTKSDIFAYGVVVWELFNQATK CCK4_Mmus GLSKDVYNSEYYHFRQAWVPLRWMSPEAVLEG----DFSTKSDVWAFGVLMWEVFTHG-E CCK4_Hsap GLSKDVYNSEYYHFRQAWVPLRWMSPEAILEG----DFSTKSDVWAFGVLMWEVFTHG-E CCK4_Spur SVSQDLYRPEYHEYHQKLIPVRWMPAEAIFED----ELSAKSDVWAYGIFVWEVFSQG-T AqueK250_Aque GIGHDLYEQDYYDNGSQLLPIRWMAPELLKDSNMGPAFSLASDIWSFGVFCWEVFSYA-Q .: :* * :*:. . :*:**:..* : :. : **::::*:. **:*. . otk_Dmel LPHEELTNEQVVQRSQAGSLEWSVAEATPDSLREILLSCWVSNPKERPSFSQLGAALSKA CCK4_Mmus MPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWAPNPKDRPSFSEIASTLGDS CCK4_Hsap MPHGGQADDEVLADLQAGKARLPQPEGCPSKLYRLMQRCWALSPKDRPSFSEIASALGDS CCK4_Spur LPYTQLDNDAVMRAMIDGELMLETPPDTPEEIELMMHRCWADSPKDRHTFSEITHHLGRI AqueK250_Aque QPYEGLSDEQVLRLVPSGHLLSLPEEGMPALLYSLLMDCWQFDPLQRPLFTEIAPAVRGI *: :: *: * * : :: ** .* :* *::: : otk_Dmel MQSAEK CCK4_Mmus PADSKQ CCK4_Hsap TVDSKP CCK4_Spur STDSRV AqueK250_Aque DV---D