CLUSTAL W (1.83) multiple sequence alignment CG7236_Dmel -----------------------------------------------------MDR---- CDKL5_Mmus MK--------------------------------------------IPNIGNVMNK---- CDKL4_Mmus -----------------------------------------------------MEK---- CDKL3_Mmus -----------------------------------------------------MEM---- CDKL2_Mmus -----------------------------------------------------MEK---- CDKL1_Mmus -----------------------------------------------------MEK---- CDKL1_Hsap M----------------------------------------------------MEK---- CDKL2_Hsap -----------------------------------------------------MEK---- CDKL5_Hsap MK--------------------------------------------IPNIGNVMNK---- CDKL4_Hsap -----------------------------------------------------MEK---- CDKL3_Hsap -----------------------------------------------------MEM---- Y42A5A.4_Cele -----------------------------------------------------MDK---- 10873_Tthe -----------------------------------------------------MNK---- 17811_Tthe -----------------------------------------------------MKSLVNL 29899_Tthe -----------------------------------------------------MNK---- 7414_Tthe -----------------------------------------------------MNK---- CDKL2_Spur MGPARKSVDAAFACQSGQRNTIDLFSRVRVAEVVPKQSEPPLPLMKGPAL--AMEK---- CDKL1_Spur -----------------------------------------------------MDK---- CDKL5_Spur -----------------------------------------------------MNK---- AqueK106_Aque -----------------------------------------------------MEK---- AqueK107_Aque -----------------------------------------------------MEK---- GK026_Glam -----------------------------------------------------MNK---- *. CG7236_Dmel ------------------------------------------------------------ CDKL5_Mmus ------------------------------------------------------------ CDKL4_Mmus ------------------------------------------------------------ CDKL3_Mmus ------------------------------------------------------------ CDKL2_Mmus ------------------------------------------------------------ CDKL1_Mmus ------------------------------------------------------------ CDKL1_Hsap ------------------------------------------------------------ CDKL2_Hsap ------------------------------------------------------------ CDKL5_Hsap ------------------------------------------------------------ CDKL4_Hsap ------------------------------------------------------------ CDKL3_Hsap ------------------------------------------------------------ Y42A5A.4_Cele ------------------------------------------------------------ 10873_Tthe ------------------------------------------------------------ 17811_Tthe KILGLYFGSRNQIGGQGMSYLGQQLLHLQNLNKFSLGLGEENKLSENSLKNFGESFNHIN 29899_Tthe ------------------------------------------------------------ 7414_Tthe ------------------------------------------------------------ CDKL2_Spur ------------------------------------------------------------ CDKL1_Spur ------------------------------------------------------------ CDKL5_Spur ------------------------------------------------------------ AqueK106_Aque ------------------------------------------------------------ AqueK107_Aque ------------------------------------------------------------ GK026_Glam ------------------------------------------------------------ CG7236_Dmel ------------------------------------------------------------ CDKL5_Mmus ------------------------------------------------------------ CDKL4_Mmus ------------------------------------------------------------ CDKL3_Mmus ------------------------------------------------------------ CDKL2_Mmus ------------------------------------------------------------ CDKL1_Mmus ------------------------------------------------------------ CDKL1_Hsap ------------------------------------------------------------ CDKL2_Hsap ------------------------------------------------------------ CDKL5_Hsap ------------------------------------------------------------ CDKL4_Hsap ------------------------------------------------------------ CDKL3_Hsap ------------------------------------------------------------ Y42A5A.4_Cele ------------------------------------------------------------ 10873_Tthe ------------------------------------------------------------ 17811_Tthe SLTHIDLDIYKHNLKNNDFGNIGNALSMCKKLQFLKIKVDQEHQITQNNIKLFANNLSQN 29899_Tthe ------------------------------------------------------------ 7414_Tthe ------------------------------------------------------------ CDKL2_Spur ------------------------------------------------------------ CDKL1_Spur ------------------------------------------------------------ CDKL5_Spur ------------------------------------------------------------ AqueK106_Aque ------------------------------------------------------------ AqueK107_Aque ------------------------------------------------------------ GK026_Glam ------------------------------------------------------------ CG7236_Dmel ------------------------------------------------------------ CDKL5_Mmus ------------------------------------------------------------ CDKL4_Mmus ------------------------------------------------------------ CDKL3_Mmus ------------------------------------------------------------ CDKL2_Mmus ------------------------------------------------------------ CDKL1_Mmus ------------------------------------------------------------ CDKL1_Hsap ------------------------------------------------------------ CDKL2_Hsap ------------------------------------------------------------ CDKL5_Hsap ------------------------------------------------------------ CDKL4_Hsap ------------------------------------------------------------ CDKL3_Hsap ------------------------------------------------------------ Y42A5A.4_Cele ------------------------------------------------------------ 10873_Tthe ------------------------------------------------------------ 17811_Tthe KTVIQIKYSLNLDREDPDDYGNQDEEDEEIEDDLEEENNEILDEENSLQNDQVKEEDEDI 29899_Tthe ------------------------------------------------------------ 7414_Tthe ------------------------------------------------------------ CDKL2_Spur ------------------------------------------------------------ CDKL1_Spur ------------------------------------------------------------ CDKL5_Spur ------------------------------------------------------------ AqueK106_Aque ------------------------------------------------------------ AqueK107_Aque ------------------------------------------------------------ GK026_Glam ------------------------------------------------------------ CG7236_Dmel ---------------------------------------------------YEKLSRLGE CDKL5_Mmus ---------------------------------------------------FEILGVVGE CDKL4_Mmus ---------------------------------------------------YEKLAKIGE CDKL3_Mmus ---------------------------------------------------YETLGKVGE CDKL2_Mmus ---------------------------------------------------YENLGLVGE CDKL1_Mmus ---------------------------------------------------YEKIGKIGE CDKL1_Hsap ---------------------------------------------------YEKIGKIGE CDKL2_Hsap ---------------------------------------------------YENLGLVGE CDKL5_Hsap ---------------------------------------------------FEILGVVGE CDKL4_Hsap ---------------------------------------------------YEKLAKTGE CDKL3_Hsap ---------------------------------------------------YETLGKVGE Y42A5A.4_Cele ---------------------------------------------------YDRLSKLGE 10873_Tthe ---------------------------------------------------YEILGVNGE 17811_Tthe DKEGDDMKEDENLSENEGNYQKDDEEFDKEDLENMDIQEFQQDMSYLGNQNSQILSILEE 29899_Tthe ---------------------------------------------------YEVKGVVGE 7414_Tthe ---------------------------------------------------YEILGVVGE CDKL2_Spur ---------------------------------------------------YESFGLVGE CDKL1_Spur ---------------------------------------------------YERLGKIGE CDKL5_Spur ---------------------------------------------------YEVLGIVGE AqueK106_Aque ---------------------------------------------------YEKISKIGE AqueK107_Aque ---------------------------------------------------YENLGLVGE GK026_Glam ---------------------------------------------------YEILGVSGE : . * CG7236_Dmel GSYGVVYKCRDRETGALVAVKRFVESED--DPAIRKIALREIRLLKNLKHPNLVSLLEVF CDKL5_Mmus GAYGVVLKCRHKETHEIVAIKKFKDSEE--NEEVKETTLRELKMLRTLKQENIVELKEAF CDKL4_Mmus GSYGVVFKCRNKSSGQVVAIKKFVESED--DRVVRKIALREIRMLKQLKHPNLVNLIEVF CDKL3_Mmus GSYGTVMKCKHKDTGRIVAIKIFYEKPE---KSVNKIATREIKFLKQFRHENLVNLIEVF CDKL2_Mmus GSYGMVMKCRNKDSGRIVAIKKFLESDD--DKMVKKIAMREIKLLKQLRHENLVNLLEVC CDKL1_Mmus GSYGVVFKCRNRDTGQIVAIKRFLETED--DPVIKKIALREIRMLKQLKHPNLVNLLEVF CDKL1_Hsap GSYGVVFKCRNRDTGQIVAIKKFLESED--DPVIKKIALREIRMLKQLKHPNLVNLLEVF CDKL2_Hsap GSYGMVMKCRNKDTGRIVAIKKFLESDD--DKMVKKIAMREIKLLKQLRHENLVNLLEVC CDKL5_Hsap GAYGVVLKCRHKATHEIVAIKKFKDSEE--NEEVKETTLRELKMLRTLKQENIVELKEAF CDKL4_Hsap GSYGVVFKCRNKTSGQVVAVKKFVESED--DPVVKKIALREIRMLKQLKHPNLVNLIEVF CDKL3_Hsap GSYGTVMKCKHKNTGQIVAIKIFYERPE---QSVNKIAMREIKFLKQFHHENLVNLIEVF Y42A5A.4_Cele GSYGVVYKCKNRDTGQIVAIKKFVETED--DPHIKKIALREIRMLKQLKHQNLVGLIEVF 10873_Tthe GAYGVVLKCRNKETQEIVAIKKFKETED--DEIAKKNIQREVKMLRQLRHKNIVDLIEAF 17811_Tthe ADYFKLYKCLNKETQKIIAIKAYKLNIN--QVEEKKRIEREVKIKKMLHHKNIVDIIEIC 29899_Tthe GAYGVVLKCMNKENGEYVAIKKFKESDE--DEVVKKTTLREVKILRMLKQENIVQLREAF 7414_Tthe GAYGVVLKCRNRETNEILAIKKFKETED--DELVRKNIQREVKMLKTLKHKNIVGLVEAF CDKL2_Spur GSYGQVLKCRHKETNQVVAIKKFLEGED--DKMVKKIAMREVRMLKQLRHENLVNLIEVF CDKL1_Spur GSYGVVFKCRHKDTGTIVAIKRFVESED--DPLIKKIALREIRMLKQLKHENLVNLKEVF CDKL5_Spur GAYGVVMKCRHKESKEVMAIKKFKDSEA--NEDVRRTILRELKLLRQLKQENIVEVREAF AqueK106_Aque GSYGVVFKCRNKDTGQIVAIKKFVESED--DPIIKKIALREIRMLRQLKHGNLVNLLEVF AqueK107_Aque GSYGMVMKCRHKDSSQLVAIKKFLETEN--DRMVKKIALREVRMLKQLRHENLVNLIEVF GK026_Glam GAYGVVLKCRNKETNELVAIKKFKDTDDPEDSTFKKTTLREVKILKNAQHPHIVCLKEAF . * : ** .: . :*:* : .. **::: : :: ::* : * CG7236_Dmel RRKRRLHLVFEFCELTVLHELER--HPQGCPEHLTKQICYQTLLGVAYCHK-QGCLHRDI CDKL5_Mmus RRRGKLYLVFEYVEKNMLELLEE--MPNGVPPEKVKSYIYQLIKAIHWCHK-NDIVHRDI CDKL4_Mmus RRKRKMHLVFEYCDHTLLNELER--NPNGVSDGVIKSVLWQTLQALNFCHK-HNCIHRDV CDKL3_Mmus RQKKKIHLVFEFIDHTVLDELQH--YCHGLESKRLRKYLFQILRAIEYLHN-NNIIHRDI CDKL2_Mmus KKKKRWYLVFEFVDHTILDDLKL--FPNGLDYQVVQKYLFQIINGIGFCHS-HNIIHRDI CDKL1_Mmus RRKRRLHLVFEYCDHTVLHELDR--YQRGVPEPLVKNITWQTLQAVNFCHK-HNCIHRDV CDKL1_Hsap RRKRRLHLVFEYCDHTVLHELDR--YQRGVPEHLVKSITWQTLQAVNFCHK-HNCIHRDV CDKL2_Hsap KKKKRWYLVFEFVDHTILDDLEL--FPNGLDYQVVQKYLFQIINGIGFCHS-HNIIHRDI CDKL5_Hsap RRRGKLYLVFEYVEKNMLELLEE--MPNGVPPEKVKSYIYQLIKAIHWCHK-NDIVHRDI CDKL4_Hsap RRKRKMHLVFEYCDHTLLNELER--NPNGVADGVIKSVLWQTLQALNFCHI-HNCIHRDI CDKL3_Hsap RQKKKIHLVFEFIDHTVLDELQH--YCHGLESKRLRKYLFQILRAIDYLHS-NNIIHRDI Y42A5A.4_Cele KRNRKLHLVFELCDRTVLHELEK--NPHGVNDELIKKIIYQLLEALKFCHS-HKCIHRDV 10873_Tthe KRKGRIYLVFEYVEKNLLEVLEE--KPTGLDHEVIRIIMYQLLKALHQCHK-QDVIHRDV 17811_Tthe QKNNEIYIVEEYVEISLSNYLKQGSQQKGLDQNVIPNIMYQVLSSINQCHK-YDIIHQNI 29899_Tthe RRKGKLYLVFEYVENNLLEILEE--RPNGLDQDDVRKYIYQLCKSISYCNS-MDIIHRDI 7414_Tthe KRKGRIYLVFEYVEKNLLEVLEE--KPSGLD----------LLKALDHCHK-HNIIHRDI CDKL2_Spur RRKKRLYLVFEFMDHTVLDELEK--YPMGLDESLVRKYMWQILKGIEFCHI-NNIIHRDI CDKL1_Spur RRKKKLHLVFEYCDYTVLNTLEA--NVNGVPEGQGMNIVYQTLEAVNFCHQ-HNCIHRDV CDKL5_Spur RRRGKLYLVFEYVEKNMLELLEE--NPKGVPPEKVRSYIYQLIKAIHWCHR-NDVIHRDI AqueK106_Aque RRKRKLHLVFEYCDHTVLNELEA--HPRGLDETSAKRIIWQTLQGVNYCHH-QN------ AqueK107_Aque RRKKRLYLVFEFVDHTALDELDK--YPSGADESLVKKIMWQVLKGVEFCHQ-HNVIHRDV GK026_Glam KRKQRLYLVFEYCEKTLLELIED--SPGGIPIETVKLLTFQMLRGVEFLWEFMEICHRDL ::. . ::* * : . . :. * .: CG7236_Dmel KPENILLTAQ---GQVKLCDFGFARMLS-----------PGENYTDYVATRWYRAPELLV CDKL5_Mmus KPENLLISHN---DVLKLCDFGFARNLSEG---------NNANYTEYVATRWYRSPELLL CDKL4_Mmus KPENILITKQ---GMIKICDFGFARILI-----------PGDAYTDYVATRWYRAPELLV CDKL3_Mmus KPENILVSQS---GITKLCDFGFARTLAA----------PGDVYTDYVATRWYRAPELVL CDKL2_Mmus KPENILVSQS---GVVKLCDFGFARTLAA----------PGEVYTDYVATRWYRAPELLV CDKL1_Mmus KPENILITKQ---SAIKLCDFGFARLLTG----------PGDYYTDYVATRWYRSPELLV CDKL1_Hsap KPENILITKH---SVIKLCDFGFARLLTG----------PSDYYTDYVATRWYRSPELLV CDKL2_Hsap KPENILVSQS---GVVKLCDFGFARTLAA----------PGEVYTDYVATRWYRAPELLV CDKL5_Hsap KPENLLISHN---DVLKLCDFGFARNLSEG---------NNANYTEYVATRWYRSPELLL CDKL4_Hsap KPENILITKQ---GIIKICDFGFAQILI-----------PGDAYTDYVATRWYRAPELLV CDKL3_Hsap KPENILVSQS---GITKLCDFGFARTLAA----------PGDIYTDYVATRWYRAPELVL Y42A5A.4_Cele KPENIFLTRN---DQVKLGDFGFARIIN-----------TTEMYTDYVATRWYRSPELLV 10873_Tthe KPENLLVNPYN--YELKLCDFGFARTLPSK---------QGEIITDYVATRWYRAPELLL 17811_Tthe KPMHIYINPSN--YELKLNGFRLARQLPQ----------KGEIVTDYVEARWYKSPEYLL 29899_Tthe KPENLLISKD---GTLKLCDFGFARVLPQ----------KGGNLTDYVATRWYRAPELLL 7414_Tthe KPENLLVNSD---GTLKLCDFGFARHMPPK---------QNEILTDYVATRWYRSPELLL CDKL2_Spur KPENILVSKS---KVVKLCDFGFARTIAG----------PGEIYTDYVATRWYRAPELLV CDKL1_Spur KPENILITKD---GRIKLCDFGFARILTG----------PDDEYTDYVATRWYRAPELLV CDKL5_Spur KPENLLISAK---DTLKLCDFGFARNLDGN---------SSANYTDYVATRWYRSPELLL AqueK106_Aque ------------------------------------------------------------ AqueK107_Aque KPENILISKR---GVVKICDFGFARAIAP----------PGEAYTDYVATRWYRAPELLV GK026_Glam KPENLLLVKKHGEWTLKLCDFGFARHINGAQTAGAAGNFPQSNLTDYVATRWYRSPELLL CG7236_Dmel GDTQYGTPVDVWAIGCLFAELVRGEALWPGRSDVDQLYLIRKTLGDLLPRHIQIFGQNEY CDKL5_Mmus GA-PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPR CDKL4_Mmus GDTKYGSSVDVWAVGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFRSNQF CDKL3_Mmus KDTSYGKPVDIWALGCMIIEMATGHPFLPSSSDLDLLHKIVLKVGNLTPHLHNIFSKSPI CDKL2_Mmus GDVKYGKAVDIWAIGCLVIEMLMGQPLFPGESDIDQLHHIMTCLGNLIPRHQELFYKNPV CDKL1_Mmus GDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSMNQY CDKL1_Hsap GDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQY CDKL2_Hsap GDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPV CDKL5_Hsap GA-PYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPR CDKL4_Hsap GDTQYGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGF CDKL3_Hsap KDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPI Y42A5A.4_Cele GDVQYGPPVDIWAVGCVYAELLTGEALWPGRSDIDQLYHIRKTLGEFLPRHISIFRTNQF 10873_Tthe KYPKYSKPVDIWAVACIMGELIDGQPLFPGQNEIDQLYLIQKTLGPLTPEQKELFIKNPR 17811_Tthe DYRKYGKPEDIWAAACVMAELIDGEPLFPGQGEIDQFYRIVQVIGPLTNQYENLFKKK-- 29899_Tthe GYTDYGKEVDMWAVGCIMGELTDGQPLFPGQNEIDQLYVIQKVLGPLTAEQQEVFLKHPG 7414_Tthe SDPGYSFPVDNWAIACIMGELIDGQPLFPGENEIDQLYLIQKLLGPLTPDQKEMFIKNPR CDKL2_Spur GDTKYGKAIDLWAVGCLQAEMLTGEPLFPGDSDIDQLYHIIRCFGTLIQRHKEIFLKNPL CDKL1_Spur GDMVYGPPVDVWAIGCVTAELIAGEALWPGRSDVDQLYLIKQTLGDLIDRHSKIFSTNHF CDKL5_Spur GS-AYGKAVDVWAIGCILGELSDGNAIFPGESEIDQLYMIQKILGPLPHYQMAIFDNSPR AqueK106_Aque -------------------------PLWPGRSDVDQLHLIIQTQGDLIPYHVKIFQESTY AqueK107_Aque GDTNYGRAVDVWAIGCLFSEMLTGEPLFPGESDIDQLYLITKCFGNLIARHREVFSRNPL GK026_Glam NATDYNQTVDIWAAALIISEMITSEPLFAGDSDVDQLYLIQRVLGNLTRKQMEKFLRNPK . .. .::* :. * * : * CG7236_Dmel FKGITLPVPPT--LEPLEDKMPAKSQQNPLTIDFL-KKCLDKDPTKRWSCEKLTKHSYFD CDKL5_Mmus FHGLRFPAVNH--PQSLERRYLGIL--NSVLLDLM-KNLLKLDPADRYLTEQCLNHPTFQ CDKL4_Mmus FRGISIPEPED--METLEEKFSN---VQPVALSFM-KGCLKMNPDERLTCAQLLDSAYFE CDKL3_Mmus FAGVVLPQVQH--PKTARKKYPK---LNGLLADIV-HACLQIDPAERTSSTDLLRHDYFT CDKL2_Mmus FAGVRLPEVKDAEAEPLESRYPK---LPEAVISLA-KKCLHIDPDKRPFCADLLRHDFFQ CDKL1_Mmus FSGVKIPDPED--METLELKFPN---ISYSALGFL-KGCLHMDPAERLTCEQLLQHPYFD CDKL1_Hsap FSGVKIPDPED--MEPLELKFPN---ISYPALGLL-KGCLHMDPTQRLTCEQLLHHPYFE CDKL2_Hsap FAGVRLPEIKE--REPLERRYPK---LSEVVIDLA-KKCLHIDPDKRPFCAELLHHDFFQ CDKL5_Hsap FHGLRFPAVNH--PQSLERRYLGIL--NSVLLDLM-KNLLKLDPADRYLTEQCLNHPTFQ CDKL4_Hsap FHGISIPEPED--METLEEKFSD---VHPVALNFM-KGCLKMNPDDRLTCSQLLESSYFD CDKL3_Hsap FAGVVLPQVQH--PKNARKKYPK---LNGLLADIV-HACLQIDPADRISSSDLLHHEYFT Y42A5A.4_Cele FFGLSIPEPEH--LEPLPSKLPN---ASSAQLDFL-QKCFEMSPDRRFSCSELMLHGIFS 10873_Tthe FIGTKFPEINK--PETIERRYLGKL--SKKALNIM-KLMLKMDPDERITAEEAMKHPYFD 17811_Tthe YKDLKFPIIKN--FNSIELRYQGK--INAEGLDLM-KMMLKMNPDERITAEQSLSHPFFD 29899_Tthe FLGVKLPEISK--PETIEKRYLGKL--SKKALSFM-KNLLKMDPSQRMSADEALQHPYFD 7414_Tthe YVGLKFPEIPK--PETIERRYLGKL--SKKALTFM-KGLLKMDPRERMNVQEAMAHPLFD CDKL2_Spur FVGMRLPEVKN--VEPLEKRFPT---LSGLSISMM-KSCLHLDPDQRPTCTQFLKHEFFK CDKL1_Spur FKGMSIPEPER--RIPLKDKVRN---LNSTALTFL-EACLQMDPADRLSCQELMEMPFFD CDKL5_Spur FSGLKVTILSI---Q-FKRSIF-RI--FSCLLAVL------------------------- AqueK106_Aque FKDTSIPCPDK--REPISALYPQ---FSQQILSFLEQGCLAMDPIARQTAEELLDHPVFD AqueK107_Aque FIGMRLPEARE--IQPFERRYHR---LSPAAMDII-KWSLRLDPADRPTCTQLLKHELFQ GK026_Glam FIGVEFPTS-R--PEGLEKKLTGKIK-DKQAISLL-KMMLKMDPAERPSATQCLDHEFFD : . .. . CG7236_Dmel D--YIA--KQR-ELE------H-VNSLEAA----------------N---LRQQ------ CDKL5_Mmus T--QRLLDRSPSRST--KRKP-YHVESSTLSNR------------NQ---STKGAALQTH CDKL4_Mmus S--FQE--DQ---MK------R-KARSEGRS---------------R---RRQQ------ CDKL3_Mmus RDGFIE--KFIPELR--AKLLQ-EAKVNSFIKP------------KE---NF-KEN---- CDKL2_Mmus MDGFAE--RFSQELQ--LKIEK-DARNNSLPKK------------SQ---NRKKEK---- CDKL1_Mmus S--IRE--VGE--LT------R-QHDKPARK---------------T---LRQS------ CDKL1_Hsap N--IRE--IED--LA------K-EHNKPTRK---------------T---LRKS------ CDKL2_Hsap MDGFAE--RFSQELQ--LKVQK-DARNVSLSKK------------SQ---NRKKEK---- CDKL5_Hsap T--QRLLDRSPSRSA--KRKP-YHVESSTLSNR------------NQ---AGKSTALQSH CDKL4_Hsap S--FQE--AQ---IK------R-KARNEGRN---------------R---RRQQ------ CDKL3_Hsap RDGFIE--KFMPELK--AKLLQ-EAKVNSLIKP------------KE---SS-KEN---- Y42A5A.4_Cele N--WIL--RIR-Q--------D-ES-TPTGL---------------T---SKRS------ 10873_Tthe G--VRE--QFDKDDN--VTKP-VSAVTIDLKRE------------NS---HLKKMP---- 17811_Tthe K--LKS--KIDNEKG--AFIQN------------------------K---LS-------- 29899_Tthe G--IRD--KEIQQTIKHGRIE-ERVESATIKEP------------KQINQNGTNSGFYNQ 7414_Tthe G--IRE--LYDDDND--HNSQSQHNKSIEKNQE------------NQ---NIRSYGS--- CDKL2_Spur KDGFCD--VFPSELS--LKVQK-EFEGNPLLKSLLGDEKGDEEKKPK---HRSKKQ---- CDKL1_Spur R--HKG--LDD-R-H------S-DSTNVRRH----------------------------- CDKL5_Spur ------------------------------------------------------------ AqueK106_Aque D--FRD--WFQPELE--MLLAR-EAKKVHKSKA-------------K---VQQA------ AqueK107_Aque RNGWAD--KYSIELR--SKIQH-EFDDNPLLKNLGVTIYGSL-YDSQ---HAAMKE---- GK026_Glam S--VRQ--RALQLEMK---CME-DMGIRPLVKE------------PQ---YSSNTL---- CG7236_Dmel ------------------------------------------------------------ CDKL5_Mmus HRSNSKDIQNLSVGLPRAEEGLPANESFLNGNLAGATLSPMHTKTYQASTQPGSSSKDLT CDKL4_Mmus ------------------------------------------------------------ CDKL3_Mmus ------------------------------------------------------------ CDKL2_Mmus ------------------------------------------------------------ CDKL1_Mmus ------------------------------------------------------------ CDKL1_Hsap ------------------------------------------------------------ CDKL2_Hsap ------------------------------------------------------------ CDKL5_Hsap HRSNSKDIQNLSVGLPRADEGLPANESFLNGNLAGASLSPLHTKTYQASSQPGSTSKDLT CDKL4_Hsap ------------------------------------------------------------ CDKL3_Hsap ------------------------------------------------------------ Y42A5A.4_Cele ------------------------------------------------------------ 10873_Tthe ------------------------------------------------------------ 17811_Tthe ------------------------------------------------------------ 29899_Tthe QTQNAST----------------------------------------------------- 7414_Tthe ------------------------------------------------------------ CDKL2_Spur ------------------------------------------------------------ CDKL1_Spur ------------------------------------------------------------ CDKL5_Spur ------------------------------------------------------------ AqueK106_Aque ------------------------------------------------------------ AqueK107_Aque ------------------------------------------------------------ GK026_Glam ------------------------------------------------------------ CG7236_Dmel ------------------------------------------------------------ CDKL5_Mmus NNNIPHLLSPKEAKSKTEFDFNIDTKPSEGPGTKYLKSSTRS--QQN------------- CDKL4_Mmus ------------------------------------------------------------ CDKL3_Mmus ---------------------------------EPVRDEKK---SVF------------- CDKL2_Mmus --------------------------------DDALGEERK---TLV------------- CDKL1_Mmus ------------------------------------------------------------ CDKL1_Hsap ------------------------------------------------------------ CDKL2_Hsap -----------------------------EK-DDSLVEERK---TLV------------- CDKL5_Hsap NNNIPHLLSPKEAKSKTEFDFNIDPKPSEGPGTKYLKSNSRS--QQN------------- CDKL4_Hsap ------------------------------------------------------------ CDKL3_Hsap ---------------------------------ELRKDERK---TVY------------- Y42A5A.4_Cele ------------------------------------------------------------ 10873_Tthe -----------------------------QT-DKQINLSRKV--DII------------- 17811_Tthe ------------------------------------------------------------ 29899_Tthe ------------------------IKPKDKPPQQQ-AIPPKN--Q-T------------- 7414_Tthe -------------KNNI------DEKKNEDQDERDSQFEKKS--QTI------------- CDKL2_Spur -----------------------------SS-SEKLERE--------------------- CDKL1_Spur ------------------------------------------------------------ CDKL5_Spur ------------------------------------------------------------ AqueK106_Aque ------------------------------------------------------------ AqueK107_Aque -----------------------------SS-GEETVPNRLTTKHDYATGFSSGAEATGS GK026_Glam -----------------------------SG-DIS--STQLQ--QNL------------- CG7236_Dmel -------------------------QLAS-----QQFML--------------------- CDKL5_Mmus RHSFMESSQSKAG---TLQPSEKQS----RH--------------SYI-DTIPQS-SRSP CDKL4_Mmus ------------------------------------------------------------ CDKL3_Mmus TNTLLYGNPSLYG---KEVDRDKRA----KELK-VRVIKAKGGKG------DVPD-QKKP CDKL2_Mmus V---------------QDTNADPKI----KDSK---VFKVKGSKI------DVEK-MEKG CDKL1_Mmus -------------------------R-KH-----L------------------------- CDKL1_Hsap -------------------------R-KH-----HCFTE--------------------- CDKL2_Hsap V---------------QDTNADPKI----KDYK---LFKIKGSKI------DGEK-AEKG CDKL5_Hsap RHSFMESSQSKAG---TLQPNEKQS----RH--------------SYI-DTIPQS-SRSP CDKL4_Hsap ------------------------------------------------------------ CDKL3_Hsap TNTLLS--SSVLG---KEIEKEKKP----KEIK-VRVIKVKGGRG------DISE-PKKK Y42A5A.4_Cele ------------------------------------------------------------ 10873_Tthe GKTES--NDIDEKNNGMVQ--NNED----HN--------------EYGESYGKQSMKLEK 17811_Tthe ------------------------------------------------------------ 29899_Tthe QQPPLGSNKQKAL---QQQPDQQQQ----RV-------------NNFVKNGVRQE-KNTP 7414_Tthe HHEQNQKNGIYAK---LNKENNNQS----QK--------------ILGKNYFSQN-KLPP CDKL2_Spur ---------------------REKEKSRKRHSETEKLKRSSTPTR------DAHH-ESSP CDKL1_Spur -------------------------R-SK-----L--GL--------------------- CDKL5_Spur ------------------------------------------------------------ AqueK106_Aque -------------------------SRSK-----GHLGG--------------------- AqueK107_Aque G---------------ADESAIKKEKKKK-----IKVHREKAANG------LPLQ-EPKP GK026_Glam QHNLHTTS---------------------SH-------------------------SINP CG7236_Dmel -----AT----------------------------------------------------- CDKL5_Mmus SYR---TKAKSHG------ALSDSKSV---------------------------S----N CDKL4_Mmus ------------------------------------------------------------ CDKL3_Mmus E---YEGDHRQQG----------------------------------------TA----- CDKL2_Mmus S---RASNA---N------CLHDNGT---------------------------NH----- CDKL1_Mmus ------------------------------------------------------------ CDKL1_Hsap ------------------------------------------------------------ CDKL2_Hsap N---RASNA---S------CLHDSRT---------------------------SH----- CDKL5_Hsap SYR---TKAKSHG------ALSDSKSV---------------------------S----N CDKL4_Hsap ------------------------------------------------------------ CDKL3_Hsap E---YEGGLGQQD----------------------------------------AN----- Y42A5A.4_Cele ------------------------------------------------------------ 10873_Tthe ------------------------QFM---------------------------Q----- 17811_Tthe ------------------------------------------------------------ 29899_Tthe SHE---NNRIIKKDIYPHPQI---NFM---------------------------QSSYSN 7414_Tthe QYL------------------QNSKMM---------------------------Q----- CDKL2_Spur KYDVKKSNP---S------TVTESQKKS-------------STIAS---TSNTSG----- CDKL1_Spur ------------------------------------------------------------ CDKL5_Spur ------------------------------------------------------------ AqueK106_Aque ------------------------------------------------------------ AqueK107_Aque K-----------T------MIPSSLLQGNMAALGGPSGSPYGSQHALLRAQQPSP----- GK026_Glam T----------------------AQSG---------------------------Q----N CG7236_Dmel ------------------------------------------------------------ CDKL5_Mmus LSE-------ARA-----QITETNTSRY------------FP----------------SS CDKL4_Mmus ------------------------------------------------------------ CDKL3_Mmus -------------------------DDT------------QP----------------SS CDKL2_Mmus -------------------------KGL-------------A----------------ST CDKL1_Mmus ------------------------------------------------------------ CDKL1_Hsap ------------------------------------------------------------ CDKL2_Hsap -------------------------NKI------------VP----------------ST CDKL5_Hsap LSE-------ARA-----QIAEPSTSRY------------FP----------------SS CDKL4_Hsap ------------------------------------------------------------ CDKL3_Hsap -------------------------ENV------------HP----------------MS Y42A5A.4_Cele ------------------------------------------------------------ 10873_Tthe ------------------------------------------------------------ 17811_Tthe ------------------------------------------------------------ 29899_Tthe IPDIYIKTKNAQNQQYNYEIQENYQPDFHNEDPDDSQQPSVPQVLIRNDTHGNHNNMVNV 7414_Tthe ------------------------------------------------------------ CDKL2_Spur -------------------------PSI------------QS----------------IS CDKL1_Spur ------------------------------------------------------------ CDKL5_Spur ------------------------------------------------------------ AqueK106_Aque ------------------------------------------------------------ AqueK107_Aque -------------------------YMY------------KP----------------ST GK026_Glam IGA-------SSL-----GIGYP--ATT------------VP----------------TS CG7236_Dmel ------------------------------------------------------------ CDKL5_Mmus CLDLNSPTSPT---PT-RHTDTRTLLSPSGRNNRN---------EGTLDSRRTTTRHSKT CDKL4_Mmus ------------------------------------------------------------ CDKL3_Mmus LDKKPSVLELT---NPL---------NPSENSD--------------------------- CDKL2_Mmus SLRDCSNVNID---HSR---------NP-------------------------------- CDKL1_Mmus ------------------------------------------------------------ CDKL1_Hsap ------------------------------------------------------------ CDKL2_Hsap SLKDCSNVSVD---HTR---------NP-------------------------------- CDKL5_Hsap CLDLNSPTSPT---PT-RHSDTRTLLSPSGRNNRN---------EGTLDSRRTTTRHSKT CDKL4_Hsap ------------------------------------------------------------ CDKL3_Hsap PDTKLVTIEPP---NPI---------NPSTNCN--------------------------- Y42A5A.4_Cele ------------------------------------------------------------ 10873_Tthe ------------------------------------------------------------ 17811_Tthe ------------------------------------------------------------ 29899_Tthe SIEDNTPYSKF---NE-RNKSK-ENIIPKGKKKKSQMSNIENFYQD---NAENSNNQEED 7414_Tthe ------------------------------------------------------------ CDKL2_Spur SSSK-LPQHIGGHNGPTNHT----TSHPSG------------------------------ CDKL1_Spur ------------------------------------------------------------ CDKL5_Spur ------------------------------------------------------------ AqueK106_Aque ------------------------------------------------------------ AqueK107_Aque PKRV-LPHDIP---SPL---------HPNA------------------------------ GK026_Glam SG---KPG-------S-SHSTYH-TIGPSGTTMG-------------------------- CG7236_Dmel -------------------------------------------------A---AQQLQTG CDKL5_Mmus MEEL------------KLPEHM---DS-----------SH-S--HSLSAP---HESFSY- CDKL4_Mmus ------------------------------------------------------------ CDKL3_Mmus --GVKEDPHAGG--CMIMPPINLTSS---------------------NLL---AANLSSN CDKL2_Mmus --------------GTAIPPLTH----------------------NLSAV---APGINAG CDKL1_Mmus ------------------------------------------------------------ CDKL1_Hsap ------------------------------------------------------------ CDKL2_Hsap --------------SVAIPPLTH----------------------NLSAV---APSINSG CDKL5_Hsap MEEL------------KLPEHM---DS-----------SH-S--HSLSAP---HESFSY- CDKL4_Hsap ------------------------------------------------------------ CDKL3_Hsap --GLKENPHCGG--SVTMPPINLTNS---------------------NLM---AANLSSN Y42A5A.4_Cele ------------------------------------------------------------ 10873_Tthe -------------------------SS-----------VY-N--YKVSDKNLEEGSFID- 17811_Tthe ------------------------------------------------------------ 29899_Tthe AEGR------------KSPLLT---NNKLYGTSVAQQKKF-R--FNV--M---AQNIQQ- 7414_Tthe -------------------------NT-----------VY-N--YNIDKD---DSSFTE- CDKL2_Spur -----------QGSSPTQTTINLTMGN-----------ITSNKSN---FT---STNMAGP CDKL1_Spur ------------------------------------------------------------ CDKL5_Spur ------------------------------------------------------------ AqueK106_Aque -----------------------------------------------------------G AqueK107_Aque -----------K--SIGAPPISLLDNQ-----------ASAT--HSITKL---KAGLQSH GK026_Glam VSNI------------TGPMVM---SN-----------FG-Q--HHTNYP---AHSVHN- CG7236_Dmel PAQA-AAIAAARDK---------------------------------------------- CDKL5_Mmus ---------------GLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARA CDKL4_Mmus ------------------------------------------------------------ CDKL3_Mmus LSH-----PNSRLTER----------------------TKKR---RTSSQTIGQ------ CDKL2_Mmus MGTI-PGVQNYRVDEK----------------------TKKY--------CNPF------ CDKL1_Mmus ------------------------------------------------------------ CDKL1_Hsap ------------------------------------------------------------ CDKL2_Hsap MGTETIPIQGYRVDEK----------------------TKKC--------SIPF------ CDKL5_Hsap ---------------GLGYTSPFSSQQRPHRHSMYVTRDKVRAKGLDGSLSIGQGMAARA CDKL4_Hsap ------------------------------------------------------------ CDKL3_Hsap LFH-----PSVRLTER----------------------AKKR---RTSSQSIGQ------ Y42A5A.4_Cele ------------------------------------------------------------ 10873_Tthe ---------------QDKNL-------------------------KVNFCM--------- 17811_Tthe ------------------------------------------------------------ 29899_Tthe ---------------NE------EAQEYPRLINIYQKQQQSRANSRSKFYKNGQLQKN-- 7414_Tthe ---------------ANGNS-------------------------KRNSNQFE------N CDKL2_Spur P--------PLRPNDK--------M-------------TKKS--------TNSY------ CDKL1_Spur ------------------------------------------------------------ CDKL5_Spur ------------------------------------------------------------ AqueK106_Aque AT-A-SSAA---TI---------------------------------------------- AqueK107_Aque SNTSITSLHELRPDLQ--------PH-----------RGDAY--------RSP------- GK026_Glam ---------------TVNYHYPVQ------------------------------------ CG7236_Dmel ------------------------------------------------------------ CDKL5_Mmus NSLQLLSPQPGEQLPPEMTVARP------SVKE----------SSRE---GASSFHT--- CDKL4_Mmus ------------------------------------------------------------ CDKL3_Mmus ------------------------------TLS----------NSRQ---------EDTG CDKL2_Mmus ------------------------------VKP----------N-------------QPP CDKL1_Mmus ------------------------------------------------------------ CDKL1_Hsap ------------------------------------------------------------ CDKL2_Hsap ------------------------------VKP----------N-------------RHS CDKL5_Hsap NSLQLLSPQPGEQLPPEMTVARS------SVKE----------TSRE---GTSSFHT--- CDKL4_Hsap ------------------------------------------------------------ CDKL3_Hsap ------------------------------VMP----------NSRQ---------EDPG Y42A5A.4_Cele ------------------------------------------------------------ 10873_Tthe YSKHIQYNLLEEQLRQKLGKEDSSSNTCSSWRP----------NQK-NSFEKKFTM---- 17811_Tthe ------------------------------------------------------------ 29899_Tthe -ANYV--------------------------------------SSQQ---MNVLLHT--- 7414_Tthe TKNRLLYDSMSVQKPPKMGPAGS------SLKK----------NQQINQINKTFYHS--- CDKL2_Spur ------------------------------YKK----------V-------------GAS CDKL1_Spur ------------------------------------------------------------ CDKL5_Spur ------------------------------------------------------------ AqueK106_Aque ------------------------------------------------------------ AqueK107_Aque ------------------------------LSP----------S-------------HPP GK026_Glam -----------QSLS-----------------PAAAQARAISNA---------------- CG7236_Dmel ------------------------------------------------------------ CDKL5_Mmus --R---QKSEGGVYHDPHS-DD-GTAPKENRH-------LYNDPVPRRVGSFYRVPSPRP CDKL4_Mmus ------------------------------------------------------------ CDKL3_Mmus PTQ---VQTEKGAFNERTG-QN-DQ----------------------------------- CDKL2_Mmus PA-------GIYNMNVSTSVSGEKY----------------------------------- CDKL1_Mmus ------------------------------------------------------------ CDKL1_Hsap ------------------------------------------------------------ CDKL2_Hsap PS-------GIYNINVTTLVSSEKN----------------------------------- CDKL5_Hsap --R---QKSEGGVYHDPHS-DD-GTAPKENRH-------LYNDPVPRRVGSFYRVPSPRP CDKL4_Hsap ------------------------------------------------------------ CDKL3_Hsap PIQ---SQMEKGIFNERTG-HS-DQ----------------------------------- Y42A5A.4_Cele ------------------------------------------------------------ 10873_Tthe -----------------KE-D--------DKQ-------Y-------------------- 17811_Tthe ------------------------------------------------------------ 29899_Tthe --EEGPDYEEKGLNLNSNT-NN-NNMNVNNNNISSQNMME-------------------- 7414_Tthe --IIGGHGSQGGLQISDRI-D--------PK----------------------------- CDKL2_Spur GS-------EKTMIHEKTL-QFDAM----------------------------------- CDKL1_Spur ------------------------------------------------------------ CDKL5_Spur ------------------------------------------------------------ AqueK106_Aque ------------------------------------------------------------ AqueK107_Aque PV---------------------------------------------------------- GK026_Glam ------------------------------------------------------------ CG7236_Dmel --------------------------------SKTSNTSLPLLPS--------------- CDKL5_Mmus DNSFH----EN--NV------------------STRVSSLPSDSSSGTNHSKRQPGFDP- CDKL4_Mmus ------------------------------------NQLLPLIPG--------------- CDKL3_Mmus --------------ISSGNKRKLNFPKCDRK-----EFHFPELPFT-------------- CDKL2_Mmus --------------LLQANKKRKEYPKADVRLPELNYNHLPE---L-------------- CDKL1_Mmus ----------------------------------TGLQYLPQLTS--------------- CDKL1_Hsap ---------------------------------TSKLQYLPQLTG--------------- CDKL2_Hsap --------------LFWASKKRREYSRTDVRLPELNYNHLPE---L-------------- CDKL5_Hsap DNSFH----EN--NV------------------STRVSSLPSESSSGTNHSKRQPAFDP- CDKL4_Hsap ------------------------------------NQLLPLIPG--------------- CDKL3_Hsap --------------MANENKRKLNFSRSDRK-----EFHFPELPVT-------------- Y42A5A.4_Cele ------------------------------------PNYLPLLNG--------------- 10873_Tthe -AQFKQTQRDN--NI------------------MSQKQVLPSIT----KKF--L--IDNG 17811_Tthe ------------------------------------------------------------ 29899_Tthe -QQVM----GN--EI------------------FQSTSQLPYIQQSSSN----------- 7414_Tthe -SSYNSTIGMS--TL------------------GISGGALPTIN----NHNKKFA-TNN- CDKL2_Spur --------------MSSQRKSKKDVSNTSPRESDREVTHLPN---L-------------- CDKL1_Spur ---------------------------------RKDNSHLPQLNS--------------- CDKL5_Spur ------------------------------------------------------------ AqueK106_Aque --------------------------------PNESSALVPQLPAL-------------- AqueK107_Aque ---------------------KKQLSNA-------GTIGLPQ---L-------------- GK026_Glam -------TRQSHYAL------------------NVEDSGLPFLPASRSGS---------- CG7236_Dmel ---------------TQ--H-----------HHHPHQ--DYV------------------ CDKL5_Mmus WKSPENISHADQLKE--KE----KQGF-FRSMKKKKK--KTQTVPNTDGPDLLTLQKAIH CDKL4_Mmus ---------------SH--I-------------SPTP--D-------------------- CDKL3_Mmus ------------VQAKEMKG------MEVKQIKVLKR--ESKKTDSSKIPTLLSMDPNQE CDKL2_Mmus -------------RALE--G------I-ARNSRLIKK--ENKCLSESRIPSLAAIDLHVS CDKL1_Mmus ---------------SR--I-------------LPAL--D-------------------- CDKL1_Hsap ---------------SS--I-------------LPAL--D-------------------- CDKL2_Hsap -------------RALG--G------I-ARNSRLTKK--ESKILSESRIPSLAAIDLHTP CDKL5_Hsap WKSPENISHSEQLKE--KE----KQGF-FRSMKKKKK--KSQTVPNSDSPDLLTLQKSIH CDKL4_Hsap ---------------SH--I-------------SPTP--D-------------------- CDKL3_Hsap ------------IQSKDTKG------MEVKQIKMLKR--ESKKTESSKIPTLLNVDQNQE Y42A5A.4_Cele ---------------NS--N------N----LVSKNF--SLQ------------------ 10873_Tthe ANSNSPTSRTA------------KLSL-GSTSQFTKQTNGQFINPS----------G--- 17811_Tthe ---------------NQ--I-------------K-------------------------- 29899_Tthe --------YNPNFK------------F-YNMYHQQQ---KQTQKPSGKMSTQHNNNTNQ- 7414_Tthe EKGGSPSSHHS------------KMSF-GSTQNYNK---MYFQSPT----------NQIN CDKL2_Spur -------------TGKD--A------K-TSERQEKKL--KAKKSHHTTMPQI-------- CDKL1_Spur ---------------QG--L-------------QESL--SKG------------------ CDKL5_Spur ------------------------------------------------------------ AqueK106_Aque -------------AATN--N-----------IIQQQI--DTE------------------ AqueK107_Aque -------------NDPS--NSHLRL-T-AKSPLVPAY--THSSYSQIHSTSGAEIDHHTH GK026_Glam ---------------------------------RAA---KVREAP-SRGNSLTV------ CG7236_Dmel ------------------------------------------------------------ CDKL5_Mmus SSSTASS--RPKEWRPEKLSDLQTQSQPLKSLRKLLHLSSSTNHPASSDPRFQPLTAQ-- CDKL4_Mmus ------------------------------------------------------------ CDKL3_Mmus K----------------------------------------------------------- CDKL2_Mmus S----------------------------------------V------------------ CDKL1_Mmus ------------------------------------------------------------ CDKL1_Hsap ------------------------------------------------------------ CDKL2_Hsap S----------------------------------------I------------------ CDKL5_Hsap SASTPSS--RPKEWRPEKISDLQTQSQPLKSLRKLLHLSSASNHPASSDPRFQPLTAQ-- CDKL4_Hsap ------------------------------------------------------------ CDKL3_Hsap K----------------------------------------------------------- Y42A5A.4_Cele ------------------------------------------------------------ 10873_Tthe -----ST--TN-------------------------ANSTSRLVNDMNFSKFHNLNVI-- 17811_Tthe ------------------------------------------------------------ 29899_Tthe ------NMNYD-------------------------QYTYSMHPYDQQDQEMKNLNII-- 7414_Tthe VSTGAAG--AN-------------------------GMTASKLLNDINMQKIQNLNVI-- CDKL2_Spur ------------------------------------------------------------ CDKL1_Spur ------------------------------------------------------------ CDKL5_Spur ------------------------------------------------------------ AqueK106_Aque ------------------------------------------------------------ AqueK107_Aque G----------------------------------------MLSSGVPRASYQLTPSGRM GK026_Glam ------------------------------------------------------MN---- CG7236_Dmel --------------------------KL-Q--------PLNKN----------------- CDKL5_Mmus ---QAKNSFSEIR------IHPLSQAtGGSSNIRQEPTPKGRPALQLPGQMD----P--- CDKL4_Mmus ----------------------------------------GRK----------------- CDKL3_Mmus --------QE---------TEPCVTVNE-W--------PDQER----------------- CDKL2_Mmus ------------------AS------HQ-G--------AG-SP----------------- CDKL1_Mmus ----------------------------------------NKK----------------- CDKL1_Hsap ----------------------------------------NKK----------------- CDKL2_Hsap ------------------TL------HQ-V--------SG-PP----------------- CDKL5_Hsap ---QTKNSFSEIR------IHPLSQASGGSSNIRQEPAPKGRPALQLPDGGCDGRRQRHH CDKL4_Hsap ----------------------------------------GRK----------------- CDKL3_Hsap --------QE---------FIPLSLLSACC--------PIF------------------- Y42A5A.4_Cele --------------------------GG-N--------HG-NN----------------- 10873_Tthe ---YNTNTYNYN--------MPLTQ----------------------------------- 17811_Tthe ------------------------------------------------------------ 29899_Tthe ---YNNNTYNYN------------------------------------------------ 7414_Tthe ---YNTNTYNYNN------VQPVNQVGNAFINQN----SQ-------------------- CDKL2_Spur ---AN---QS---------D------HG-G--------HG-FN----------------- CDKL1_Spur --------------------------HQ-N--------LGHKK----------------- CDKL5_Spur ------------------------------------------------------------ AqueK106_Aque --------------------------RR------------G------------------- AqueK107_Aque RHPPH---QDPGPQSGFSLL------HQ-K--------PS-SP----------------- GK026_Glam -------------------------VGGNN--MFLNPPKYGIP----------------- CG7236_Dmel ------------------------------------------------------------ CDKL5_Mmus --------------------------GWHVSSVTRSATEGPSYSEQLGAKS--------- CDKL4_Mmus ------------------------------------------------------------ CDKL3_Mmus ------------------------------------------------------------ CDKL2_Mmus ------------------------------------------------------------ CDKL1_Mmus ------------------------------------------------------------ CDKL1_Hsap ------------------------------------------------------------ CDKL2_Hsap ------------------------------------------------------------ CDKL5_Hsap SGPQDRRFMLRTTEQQGEYFCCGDPKKPHTPCVPNRAL------------HRPISSPAPY CDKL4_Hsap ------------------------------------------------------------ CDKL3_Hsap ------------------------------------------------------------ Y42A5A.4_Cele ------------------------------------------------------------ 10873_Tthe ------------------------------------------------------------ 17811_Tthe ------------------------------------------------------------ 29899_Tthe ------------------------------------------------------------ 7414_Tthe ------------------------------------------------------------ CDKL2_Spur ------------------------------------------------------------ CDKL1_Spur ------------------------------------------------------------ CDKL5_Spur ------------------------------------------------------------ AqueK106_Aque ------------------------------------------------------------ AqueK107_Aque ------------------------------------------------------------ GK026_Glam ------------------------------------------------------------ CG7236_Dmel -------------------------------------------------AN--L-LHRTE CDKL5_Mmus -----------GPN---------------G--------------HPYNRTNRSRMPNLND CDKL4_Mmus -------------------------------------------------QV--VQ-LK-F CDKL3_Mmus ----------------------------------------------REPTGRGGHRVEMA CDKL2_Mmus -------------------------------------------------LSD-DSEADLP CDKL1_Mmus -------------------------------------------------YH--CSTKRFN CDKL1_Hsap -------------------------------------------------YY--CDTKKLN CDKL2_Hsap -------------------------------------------------LSD-DSGADLP CDKL5_Hsap PVLQVRGTSMCPTLQVRGTDAFSCPTQQSGFSFFVRHVMREALIHRAQVNQAALLTYHEN CDKL4_Hsap -------------------------------------------------QV--LQ-LK-F CDKL3_Hsap ----------------------------------------------TNICSQLTIRVEMA Y42A5A.4_Cele ------------------------------------------------NNN--GNGIN-R 10873_Tthe ---------------------------------------------------KAANNTKKT 17811_Tthe -------------------------------------------------EN--L-KNQAH 29899_Tthe ------------------------------------------------I---NNSPLWNS 7414_Tthe --------------------------------------------------SKKSFGTGTM CDKL2_Spur -------------------------------------------------AN--ASYSSTD CDKL1_Spur ------------------------------------------------VEN--EKLLK-R CDKL5_Spur -----------------------------------------------------------K AqueK106_Aque ------------------------------------------------HQH--QKSDS-V AqueK107_Aque -------------------------------------------------RV--LRTSETS GK026_Glam ----------------------------------------------KNPQSR--GALLPK CG7236_Dmel HHLP----TI CDKL5_Mmus LKE----TAL CDKL4_Mmus DHLP----NI CDKL3_Mmus IVR----GRI CDKL2_Mmus RMEH----QH CDKL1_Mmus YHFP----NI CDKL1_Hsap YRFP----NI CDKL2_Hsap QMEH----QH CDKL5_Hsap AAL----TGK CDKL4_Hsap DHLP----NI CDKL3_Hsap IAR----GRI Y42A5A.4_Cele NFLP---TIS 10873_Tthe KPK----YQI 17811_Tthe QDLQ----KN 29899_Tthe ISK----KKI 7414_Tthe YKK----KNY CDKL2_Spur HNLP----AV CDKL1_Spur DRLPNIDSFK CDKL5_Spur NNH----IHM AqueK106_Aque DHLP---SLT AqueK107_Aque QLAP----TN GK026_Glam IRD----TRY