CLUSTAL W (1.83) multiple sequence alignment Doa_Dmel MCVRFQMPRT-------------------------------------------------- CLK4_Mmus MRHSKRT----------------------------------------------------- CLK3_Mmus MPVLSARRKRLASTAGPR-RG------------S-------------------------- CLK2_Mmus MPHPRRYH---SSERGSR--G------------S-------------------------- CLK1_Mmus MRHSKRT----------------------------------------------------- E02H4.3_Cele MPILHQKI---ASTGGQPSTN------------S-------------------------- C16A11.3_Cele MEHDSSEDSD--QFEPPR--APVSS----------------------------------- KNS1_Scer MSQNIQIGT--------------------------------------------------- CLK4_Hsap MRHSKRT----------------------------------------------------- CLK3_Hsap MPVLSARRRELADHAGSG-RR------------S-------------------------- CLK2_Hsap MPHPRRYH---SSERGSR--G------------S-------------------------- CLK1_Hsap MAAGRRPA---SALWPER-RG------------SPL----RGDLLGFQNVREPSSCGETL Y111B2A.1_Cele MKRASTCLQH--HSLPAK--K--------------------------------------- ClkA_Ddis MDRFQTKRKTYSYNGYSN--N------------D-------------------------- 22369_Tthe MGSKDRTKNYRE-YRGSI--S------------KKYKNNQSGNYSKFQN-RQNSRSRSRS CLK_Spur MSRGASSPDS---IHGMP------------------------------------------ CC1G_01467_Ccin MLASDRGHS---VQYS----ALVQDL---------------------------------- CC1G_10232_Ccin MDTTPLLPPG--LSFPYR--RNGSRFELWLIKMS-------------------------- CC1G_15475_Ccin MLPAHELKR--------------------------------------------------- CC1G_06417_Ccin MSAAVHPLNPHHISHYSR--S--------------------------------------- AqueK109_Aque MLTTMCVRGNA------------------------------------------------- CLK_a_Smoe MLIDIWLVQFA-P-AG-------------------------------------------- CLK_d_Smoe SPPW-------------------------------------------------------- CLK_b_Smoe MVGT-------------------------------------------------------- CLK_c_Smoe MVTAAALQV--------------------------------------------------- GK028_Glam MALSSRPNT---ARR--------------------------------------------- Doa_Dmel ------------------------------------------------------------ CLK4_Mmus ------------------------------------------------------------ CLK3_Mmus -GPSLAVRWVPPLGPEPSSDRGRAPMR----------------------PRGPT---CST CLK2_Mmus -----------------------------------------------------Y------ CLK1_Mmus ------------------------------------------------------------ E02H4.3_Cele ----LALRRLP------------------------------------------------- C16A11.3_Cele ------------------------------------------------------------ KNS1_Scer ------------------------------------------------------------ CLK4_Hsap ------------------------------------------------------------ CLK3_Hsap -GPSPTARSGPHL----SALRA-QPARAAH-LS----------------GRGTY---VRR CLK2_Hsap -----------------------------------------------------Y------ CLK1_Hsap SG---------------------------------------------------------- Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis -----------------------------------------------------YGYYN-- 22369_Tthe Q-----------------QQRN-APAQYQNSFQNNEKLRYDNNNNRYQQNQYSQ---NDR CLK_Spur ------------------------------------------------------------ CC1G_01467_Ccin ------------------------------------------------------------ CC1G_10232_Ccin -----------------------FPLL--------------------------------- CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin ------------------------------------------------------------ AqueK109_Aque ------------------------------------------------------------ CLK_a_Smoe ------------------------------------------------------------ CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel ------------------------------------------------------------ CLK4_Mmus ------------------------------------------------------------ CLK3_Mmus TRRGAGRGPRLLPGPPGRD---------LHRCRPDPGGAGQSPRVCEFGARAVRPLGRVE CLK2_Mmus ------------------------------------------------------------ CLK1_Mmus ------------------------------------------------------------ E02H4.3_Cele ------------------------------------------------------------ C16A11.3_Cele ------------------------------------------------------------ KNS1_Scer ------------------------------------------------------------ CLK4_Hsap ------------------------------------------------------------ CLK3_Hsap DTAGGGPGQARPLGPPGTS---------LLGRGARRSGEGWCPGAFESGARAARPPSRVE CLK2_Hsap ------------------------------------------------------------ CLK1_Hsap ------------------------------------------------------------ Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis ------------------------------------------------------------ 22369_Tthe DFRGGSVERRYDQGPNNQYSRNEGRDNNNFGRNNYKNDTGY------------------- CLK_Spur ------------------------------------------------------------ CC1G_01467_Ccin ------------------------------------------------------------ CC1G_10232_Ccin ------------------------------------------------------------ CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin ------------------------------------------------------------ AqueK109_Aque ------------------------------------------------------------ CLK_a_Smoe ------------------------------------------------------------ CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel ---------------------------------------------------RRL------ CLK4_Mmus ------------------------------------------------------------ CLK3_Mmus PGPPTAASREGAVLPRAEARAGSGRGARSGEWGLAAAGAWETMHH-----CKRY------ CLK2_Mmus ------------------------------------------------------------ CLK1_Mmus ------------------------------------------------------------ E02H4.3_Cele --------------------------------------------LVVIPRKRKY------ C16A11.3_Cele ------------------------------------------------------------ KNS1_Scer -------------------------------------------------R-KRS------ CLK4_Hsap ------------------------------------------------------------ CLK3_Hsap PRLATAASREGAGLPRAEVAAGSGRGARSGEWGLAAAGAWETMHH-----CKRY------ CLK2_Hsap ------------------------------------------------------------ CLK1_Hsap ------------------------------------------MRH-----SKRT------ Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis -----------------------------------------------------NNCSNVN 22369_Tthe -------SRGG------------------------------------------------- CLK_Spur --------------------------------------------V-----AHCM------ CC1G_01467_Ccin ---------------------------------------------T-----IFA------ CC1G_10232_Ccin --------------------------------------------FT-----ILL------ CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin ------------------------------------------------------------ AqueK109_Aque ------------------------------------------------------------ CLK_a_Smoe ------------------------------------------LD----PR-RRV------ CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------PN---------- GK028_Glam ------------------------------------------------------------ Doa_Dmel -----H--HSR--------DRS-------------------------------------- CLK4_Mmus -----H--CPD--------WDSRE--------------------------------SWGH CLK3_Mmus -----R--SPE--------PDP-------------------------------------- CLK2_Mmus -------------------HEH-------------------------------------- CLK1_Mmus -----Y--CPD--------WDERD-------------------------------WDYGT E02H4.3_Cele -----KNYVSR--------RRN-------------------------------------- C16A11.3_Cele ----------I--------KIECQ---------------------------------CGT KNS1_Scer -----R--ANM--------NNSTT---------------------------------TGP CLK4_Hsap -----H--CPD--------WDSRE--------------------------------SWGH CLK3_Hsap -----R--SPE--------PDP-------------------------------------- CLK2_Hsap -------------------REH-------------------------------------- CLK1_Hsap -----Y--CPD--------WDDKD-------------------------------WDYGK Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis YNNDIH--YKNNNYNNNNNNNNSNSGNNFNNNNNNNNNNNNNNNNNNNNNNNNNNYTYGN 22369_Tthe -------------------------------------------------------RDYSP CLK_Spur -----H--CTQ--------HCT-------------------------------------- CC1G_01467_Ccin ---------------------------------------------------------YGE CC1G_10232_Ccin -----H--LEL--------DDLRQ---------------------------------LGA CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin -----N--LPA--------VTQSI---------------------------------AGP AqueK109_Aque ------------------------------------------------------------ CLK_a_Smoe -----L--CN-----------SSY---------------------------------AWP CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel ------------------------------------------S----------------- CLK4_Mmus --------------------------------E---------S----------------- CLK3_Mmus ------------------------------------------Y----------------- CLK2_Mmus ------------------------------------------Y----------------- CLK1_Mmus --------------------------------W---------R----------------- E02H4.3_Cele ------------------------------------------TQLLASLRRCVSDPN-VY C16A11.3_Cele N--------------------------------------NTNN----------------- KNS1_Scer ANNT-------------------------------------------------------- CLK4_Hsap --------------------------------E---------S----------------- CLK3_Hsap ------------------------------------------Y----------------- CLK2_Hsap ------------------------------------------Y----------------- CLK1_Hsap --------------------------------W---------R----------------- Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis NNNNNSNNNNNNINNNGNSNNNNNNSNGSENNY---------F----------------- 22369_Tthe --------------------------------QR--------SNGVDSRRKSLSQKNQR- CLK_Spur ------------------------------------------L------RTCLV------ CC1G_01467_Ccin SDR-----------------------------YLSILPFVRAL----------------- CC1G_10232_Ccin T--------------------------------------SQRL----------------- CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin SVMA----------------------------N---------A----------------- AqueK109_Aque ------------------------------------------------------------ CLK_a_Smoe TSS--------------------------------------------------------- CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel ------------------------------------------------------------ CLK4_Mmus ------------------------------------------------------------ CLK3_Mmus ------------------------------------------------------------ CLK2_Mmus ------------------------------------------------------------ CLK1_Mmus ------------------------------------------------------------ E02H4.3_Cele KSYNHWKALLRPMTPIKSGAPTPKTVTPMPVPQIPPHQKMTPNPTPTQNPVQLPLPHAVS C16A11.3_Cele ------------------------------------------------------------ KNS1_Scer ------------------------------------------------------------ CLK4_Hsap ------------------------------------------------------------ CLK3_Hsap ------------------------------------------------------------ CLK2_Hsap ------------------------------------------------------------ CLK1_Hsap ------------------------------------------------------------ Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis ------------------------------------------------------------ 22369_Tthe ------------------------------------------------------------ CLK_Spur ------------------------------------------------------------ CC1G_01467_Ccin ------------------------------------------------------------ CC1G_10232_Ccin ------------------------------------------------------------ CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin ------------------------------------------------------------ AqueK109_Aque ------------------------------------------------------------ CLK_a_Smoe ------------------------------------------------------------ CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel ------------------------------------------------------------ CLK4_Mmus ------------------------------------------------------------ CLK3_Mmus ------------------------------------------------------------ CLK2_Mmus ------------------------------------------------------------ CLK1_Mmus ------------------------------------------------------------ E02H4.3_Cele EKPGDKKSTGPT-PSPVPSKAPISAAKLPGTVTKVAPLLSAAQPPPKT------------ C16A11.3_Cele ------------------------------------------------------------ KNS1_Scer ------------------------------------------------------------ CLK4_Hsap ------------------------------------------------------------ CLK3_Hsap ------------------------------------------------------------ CLK2_Hsap ------------------------------------------------------------ CLK1_Hsap ------------------------------------------------------------ Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis ------------------------------------------------------------ 22369_Tthe ---------YYSQNQYSQGGN-------------------QAQSYPYQQNSFNQAQQSHY CLK_Spur ------------------------------------------------------------ CC1G_01467_Ccin ------------------------------------------------------------ CC1G_10232_Ccin ------------------------------------------------------------ CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin ------------------------------------------------------------ AqueK109_Aque ------------------------------------------------------------ CLK_a_Smoe ------------------------------------------------------------ CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel ------------------------------------------------------------ CLK4_Mmus ------------------------------------------------------------ CLK3_Mmus ------------------------------------------------------------ CLK2_Mmus ------------------------------------------------------------ CLK1_Mmus ------------------------------------------------------------ E02H4.3_Cele -------LAPAPGASETNSGSGPVSKQVSGKLTEL--K-------------------SKN C16A11.3_Cele ------------------------------------------------------------ KNS1_Scer ------------------------------------------------------------ CLK4_Hsap ------------------------------------------------------------ CLK3_Hsap ------------------------------------------------------------ CLK2_Hsap ------------------------------------------------------------ CLK1_Hsap ------------------------------------------------------------ Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis ------------------------------------------------------------ 22369_Tthe GNSYPNHQQSSYNNNNNNSNSNYKKENVEDYYKNRDYKDWNNRDGNRNDRQNNNYSSNNN CLK_Spur ------------------------------------------------------------ CC1G_01467_Ccin ------------------------------------------------------------ CC1G_10232_Ccin ------------------------------------------------------------ CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin ------------------------------------------------------------ AqueK109_Aque ------------------------------------------------------------ CLK_a_Smoe ------------------------------------------------------------ CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel ------------------------------------------------------------ CLK4_Mmus ------------------------------------------------------------ CLK3_Mmus ------------------------------------------------------------ CLK2_Mmus ------------------------------------------------------------ CLK1_Mmus ------------------------------------------------------------ E02H4.3_Cele GTVTEKTEKAVLRIPSSAST--RAKAASAVAPEANPAPVPTATKPSPFAPAIAPLRDGAP C16A11.3_Cele ------------------------------------------------------------ KNS1_Scer ------------------------------------------------------------ CLK4_Hsap ------------------------------------------------------------ CLK3_Hsap ------------------------------------------------------------ CLK2_Hsap ------------------------------------------------------------ CLK1_Hsap ------------------------------------------------------------ Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis ------------------------------------------------------------ 22369_Tthe GNHNNSNNSRFTNNPSGHSTINNS------------------------------------ CLK_Spur ------------------------------------------------------------ CC1G_01467_Ccin ------------------------------------------------------------ CC1G_10232_Ccin ------------------------------------------------------------ CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin ------------------------------------------------------------ AqueK109_Aque ------------------------------------------------------------ CLK_a_Smoe ------------------------------------------------------------ CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel ------------------------------------------------------------ CLK4_Mmus ------------------------------------------------------------ CLK3_Mmus ------------------------------------------------------------ CLK2_Mmus ------------------------------------------------------------ CLK1_Mmus ------------------------------------------------------------ E02H4.3_Cele AQPPAPIQASAPLRPPVAKQNSLQKPPEPKRSVGAPPKALPSELVNKIDGIEFLPQS--- C16A11.3_Cele ------------------------------------------------------------ KNS1_Scer ------------------------------------------------------------ CLK4_Hsap ------------------------------------------------------------ CLK3_Hsap ------------------------------------------------------------ CLK2_Hsap ------------------------------------------------------------ CLK1_Hsap ------------------------------------------------------------ Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis ------------------------------------------------------------ 22369_Tthe -------------------NNSYDKRNESYRQAN----TFPSDQYSRGNGSGNGNQNSFN CLK_Spur ------------------------------------------------------------ CC1G_01467_Ccin ------------------------------------------------------------ CC1G_10232_Ccin ------------------------------------------------------------ CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin ------------------------------------------------------------ AqueK109_Aque ------------------------------------------------------------ CLK_a_Smoe ------------------------------------------------------------ CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel ------------------------------------------------------------ CLK4_Mmus ------------------------------------------------------------ CLK3_Mmus ------------------------------------------------------------ CLK2_Mmus ------------------------------------------------------------ CLK1_Mmus ------------------------------------------------------------ E02H4.3_Cele -------------------SNQNTDDGQQ------------------------------- C16A11.3_Cele ------------------------------------------------------------ KNS1_Scer ------------------------------------------------------------ CLK4_Hsap ------------------------------------------------------------ CLK3_Hsap ------------------------------------------------------------ CLK2_Hsap ------------------------------------------------------------ CLK1_Hsap ------------------------------------------------------------ Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis ------------------------------------------------------------ 22369_Tthe KNDNNSNYNSYNGNRSYKNEYQNSSQGHKQYGNNNNNYDNKRVSSQNYRNLTGGGGSYNN CLK_Spur ------------------------------------------------------------ CC1G_01467_Ccin ------------------------------------------------------------ CC1G_10232_Ccin ------------------------------------------------------------ CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin ------------------------------------------------------------ AqueK109_Aque ------------------------------------------------------------ CLK_a_Smoe ------------------------------------------------------------ CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel ----------------------AGTRDK-R------------------------------ CLK4_Mmus ----------------------YSGSHKRK------------------------------ CLK3_Mmus ----------------------LSYRWK-R------------------------------ CLK2_Mmus ----------------------QSRKHK-R------------------------------ CLK1_Mmus ----------------------SSSSHKRK------------------------------ E02H4.3_Cele -------------------PTTSTGGAKAL------------------------------ C16A11.3_Cele ----------------------RLI----------------------------------- KNS1_Scer ------------------------SSNKTF------LDNFEETRTNKLLDEMFARQNSFL CLK4_Hsap ----------------------YRGSHKRK------------------------------ CLK3_Hsap ----------------------LSYRWK-R------------------------------ CLK2_Hsap ----------------------RSRKHK-R------------------------------ CLK1_Hsap ----------------------SSSSHKRR------------------------------ Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis ----------------------QSENQS-N------------------------------ 22369_Tthe NGNFRRSNSNRNRSNNNYKNYG-------------------------------------- CLK_Spur ----------------------QGTSHQ-VGTPVAIV-----------------KGG--- CC1G_01467_Ccin ----------------------RGMVNV-R------------------------------ CC1G_10232_Ccin ----------------------RNLINAYR------------------------------ CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin ----------------------SPVTTRKR------------------------------ AqueK109_Aque ----------------------DGVSDK-K------------------------------ CLK_a_Smoe ------------------------------------------------------------ CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel ----R-RHDT-------A----------------------DH-SPP-------------- CLK4_Mmus ----R-RSHS-------S----------------------TQENRH-------------- CLK3_Mmus ----R-RSYS-------R----------------------EHE-GR-------------- CLK2_Mmus ----R-RSRS-------W----------------------SSSSDR-------------- CLK1_Mmus ----K-RSHS-------S----------------------AREQKR-------------- E02H4.3_Cele ----R-RAYG-------S----------------------KSGTTI-------------- C16A11.3_Cele ----------------------------------------------KC------------ KNS1_Scer TDNLR-NSLD-------L----------------------NQADNP-------------- CLK4_Hsap ----R-RSHS-------S----------------------TQENRH-------------- CLK3_Hsap ----R-RSYS-------R----------------------EHE-GR-------------- CLK2_Hsap ----R-RSRS-------W----------------------SSSSDR-------------- CLK1_Hsap ----K-RSHS-------S----------------------AQENKR-------------- Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis ----K-DQNS-------Y----------------------FNSSYL-------------- 22369_Tthe ---------------------------------------------R-------------- CLK_Spur ---NKGLHLM-------SEIGTEMTGISMPKITGLADIALGAENTT-------------- CC1G_01467_Ccin ----R-LSLH-------V----------------------SSDNTDYI------------ CC1G_10232_Ccin ----R-RVWYFPRFLTAW----------------------HL-----GPDIFLAKMELTG CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin ----K-RAHQ-------Y----------------------TVSYS--------------- AqueK109_Aque ----K-S-SS-------L----------------------SSLSTS-------------- CLK_a_Smoe --------------------------------------------QT-------------- CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel ------------------------------------------L----------------- CLK4_Mmus ------------------------------------------CKPHH------------- CLK3_Mmus ------------------------------------------LRYPS------------- CLK2_Mmus ------------------------------------------TRR--------------- CLK1_Mmus ------------------------------------------CRYDH------------- E02H4.3_Cele ------------------------------------------CA---------------- C16A11.3_Cele VGCAQWQHAVCMGVRPTDCVTAYKCEDCEPRLLIVTIAEAESFQGVK------------- KNS1_Scer ------------------------------------------L----------------- CLK4_Hsap ------------------------------------------CKPHH------------- CLK3_Hsap ------------------------------------------LRYPS------------- CLK2_Hsap ------------------------------------------TRR--------------- CLK1_Hsap ------------------------------------------CKYNH------------- Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis ------------------------------------------RNPVDNYNHNNNNHNNNA 22369_Tthe ------------------------------------------DNNNF------------- CLK_Spur ------------------------------------------ENL--------------- CC1G_01467_Ccin LYCLHREGQL--------------------------------SLPRR------------- CC1G_10232_Ccin AICAGWQALR--------------------------------FLDRL------------- CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin ------------------------------------------------------------ AqueK109_Aque --------------------------------------------LPM------------- CLK_a_Smoe ------------------------------------------W----------------- CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel --------------------------------A-EAP--SPP------------------ CLK4_Mmus --------------------------------QFKDS--DCH------------------ CLK3_Mmus --------------------------------R-REP--PPR------------------ CLK2_Mmus --------------------------------R-RRE--DSY------------------ CLK1_Mmus --------------------------------S-KTT--DSY------------------ E02H4.3_Cele ------------------------------------I--GSP------------------ C16A11.3_Cele --------------------------------P-PEP--TPAPKIERKTTKVLYIQRFLD KNS1_Scer ---------------------------------------------RPRQHQHQLFLDNEN CLK4_Hsap --------------------------------QFKES--DCH------------------ CLK3_Hsap --------------------------------R-REP--PPR------------------ CLK2_Hsap --------------------------------R-RRE--DSY------------------ CLK1_Hsap --------------------------------S-KMC--DSH------------------ Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis FDNNNYNTQNLGDYSYKNDGYNNDNNNNDNNNSYGDTDREKY------------------ 22369_Tthe ---------------------------------RRNN--SPR------------------ CLK_Spur --------------------------------H-HHP--KAG------------------ CC1G_01467_Ccin --------------------------------S-TLP--SLR------------------ CC1G_10232_Ccin --------------------------------P-PDP--STGLDVFVRIAGAIAL-GRHL CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin --------------------------------EVKEL--DSD---G-------------- AqueK109_Aque --------------------------------Q-PLP--SKD---A-------------- CLK_a_Smoe ---------------------------------------------Q-------------- CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel -----------------------RIT-NT----HHT----RSAA-------------KRR CLK4_Mmus -----------------------YLE-ARC------------LN-------------ERD CLK3_Mmus -----------------------RSR-SRS----HD----RIPY-------------QRR CLK2_Mmus -----------------------HVR-SRS---SYD----DHSS-------------DRR CLK1_Mmus -----------------------YLE-SRS------------IN-------------EKA E02H4.3_Cele -----------------------NVP-STS---QPQ----QGDN-------------EKR C16A11.3_Cele FLSDKS-ENIKSPLPLTKFFQDYKTK-SNCSQSLAT----AKKK--LLANLFEHIVMSAK KNS1_Scer AIELDEEP---------------RII-NTT------------IN-------------NSN CLK4_Hsap -----------------------YLE-ARS------------LN-------------ERD CLK3_Hsap -----------------------RSR-SRS----HD----RLPY-------------QRR CLK2_Hsap -----------------------HVR-SRS---SYD----DRSS-------------DRR CLK1_Hsap -----------------------YLE-SRS------------IN-------------EKD Y111B2A.1_Cele ------------------------------AYSSCG----EKLE-------------FR- ClkA_Ddis -----------------------SIE--KI---CNE-NDYDSV--------------NNN 22369_Tthe -----------------------RNY-NR-----YD----NRNY-------------ERR CLK_Spur -----------------------TAE-TTT---VTG------------------------ CC1G_01467_Ccin ------------------------HV----VLNSSS----DLLPIASRRDLF-SIVL-TD CC1G_10232_Ccin FEAGYVLGRFDVPAI---IQYRQFER----DVLGLS----GGTQIRQLMDTY-GIIA-WF CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin -----------------------KVREVIV---IEDTPPPPTLS-------------PAT AqueK109_Aque -----------------------ILP-SSS---SSS----SSS----------------- CLK_a_Smoe ------------------------------------------------------------ CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel ------------------------------------------------------------ CLK4_Mmus ------------------------------------------------------------ CLK3_Mmus ------------------------------------------------------------ CLK2_Mmus ------------------------------------------------------------ CLK1_Mmus ------------------------------------------------------------ E02H4.3_Cele ------------------------------------------------------------ C16A11.3_Cele YNDDRKAEM-LFAIGLRVEDEFLERLRGRATVEVDDCQRITFYKSKTSTSSPETVSFVLA KNS1_Scer ------------------------------------------------------------ CLK4_Hsap ------------------------------------------------------------ CLK3_Hsap ------------------------------------------------------------ CLK2_Hsap ------------------------------------------------------------ CLK1_Hsap ------------------------------------------------------------ Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis ------------------------------------------------------------ 22369_Tthe ------------------------------------------------------------ CLK_Spur ------------------------------------------------------------ CC1G_01467_Ccin FMDGRAVDYLAHSLHFDVNRTHLTSLRIRIKAGLDLSQTV-LPTLQENLPKL-------- CC1G_10232_Ccin PF----------------------------------------KKLVVRLGRR-------- CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin ------------------------------------------------------------ AqueK109_Aque ------------------------------------------------------------ CLK_a_Smoe ------------------------------------------------------------ CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel -----------------------------------------------RHE-LD--AKKAQ CLK4_Mmus -----------------------------------------------YRDRRY--IDEYR CLK3_Mmus -----------------------------------------------YREHRD--SDTYR CLK2_Mmus -----------------------------------------------LYDRRY--CGSYR CLK1_Mmus -----------------------------------------------YHSRRY--VDEYR E02H4.3_Cele -----------------------------------------------LIEKKL--SL--R C16A11.3_Cele ATTAIAEAH-----------------------LSD---ASVIDGISAIEFFKY--IENYA KNS1_Scer -----------------------------------------------NHNSSR--VDEDA CLK4_Hsap -----------------------------------------------YRDRRY--VDEYR CLK3_Hsap -----------------------------------------------YRERRD--SDTYR CLK2_Hsap -----------------------------------------------VYDRRY--CGSYR CLK1_Hsap -----------------------------------------------YHSRRY--IDEYR Y111B2A.1_Cele ---------------------------------------------------RF------- ClkA_Ddis -----------------------------------------------NNNRNY--SNSYN 22369_Tthe -----------------------------------------------DSQSRR--TDKYQ CLK_Spur ------------------------------------------------------------ CC1G_01467_Ccin ETLSVEQPKLNAKEVLTALATNSGWFTEMQCFALNPSAGV-LYER------KKYGI---- CC1G_10232_Ccin EVVRVSLA-ITNVNPIDFVINNSGCTAMMQI----ITPRR-------------------- CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin -----------------------------------------------THNGGY--SASYQ AqueK109_Aque ------------------------------------------------------------ CLK_a_Smoe ------------------------------------------------------------ CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel IS-KE-------P------------TF--------------------------------- CLK4_Mmus -NDYC-------E------------GY--------------------------------- CLK3_Mmus CEERS-------P------------SF--------------------------------- CLK2_Mmus RNDYS-------R------------DR--------------------------------- CLK1_Mmus -NDYM--------------------GY--------------------------------- E02H4.3_Cele KKKLS---GEGVP------------PA--------------------------------- C16A11.3_Cele -KDKA-------LLSLCDDLQQKIQGL--------------------------------- KNS1_Scer -DDDIIFIKEQPI------------QF--------------------------------- CLK4_Hsap -NDYC-------E------------GY--------------------------------- CLK3_Hsap CEERS-------P------------SF--------------------------------- CLK2_Hsap RNDYS-------R------------DR--------------------------------- CLK1_Hsap -NDYT-------Q------------GC--------------------------------- Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis NNNYN-------D------------GNNNYNSNNYNYNNNNNNNNNINNNNNSNSNSNSN 22369_Tthe NLD--------------------------------------------------------- CLK_Spur ------------------------------------------------------------ CC1G_01467_Ccin ------------------------------------------------------------ CC1G_10232_Ccin ------------------------------------------------------------ CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin PPALA-------P------------IR--------------------------------- AqueK109_Aque ------------------------------------------------------------ CLK_a_Smoe ------------------------------------------------------------ CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel ------------------------------------------------------------ CLK4_Mmus ------------------------------------------------------------ CLK3_Mmus ------------------------------------------------------------ CLK2_Mmus ------------------------------------------------------------ CLK1_Mmus ------------------------------------------------------------ E02H4.3_Cele ------------------------------------------------------------ C16A11.3_Cele ------------------------------------------------------------ KNS1_Scer ------------------------------------------------------------ CLK4_Hsap ------------------------------------------------------------ CLK3_Hsap ------------------------------------------------------------ CLK2_Hsap ------------------------------------------------------------ CLK1_Hsap ------------------------------------------------------------ Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis SNSNSNSNSNSNSNNNNYNNYGYNNHKSNNGGNRYSDDDDNVFNNNNNNNNNNNNNYNNY 22369_Tthe ------------------------------------------------------------ CLK_Spur ------------------------------------------------------------ CC1G_01467_Ccin ------------------------------------------------------------ CC1G_10232_Ccin ------------------------------------------------------------ CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin ------------------------------------------------------------ AqueK109_Aque ------------------------------------------------------------ CLK_a_Smoe ------------------------------------------------------------ CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel ----------------D-----DS---IST------------------------------ CLK4_Mmus ----------------V-----PR---HYH------------------------------ CLK3_Mmus ----------------G-----ED---CYG------------------------------ CLK2_Mmus ----------------G-----EA---YYD------------------------------ CLK1_Mmus ----------------E-----PG---HPY------------------------------ E02H4.3_Cele ----------------G-----SM---LTGSKSGVE---------------------IGL C16A11.3_Cele ----------------EA-----MDKKIQY------------------------------ KNS1_Scer ----------------SSPLILPS---S----SSINNNNNIVTSNNPGCGTAATSNST-- CLK4_Hsap ----------------V-----PR---HYH------------------------------ CLK3_Hsap ----------------G-----ED---YYG------------------------------ CLK2_Hsap ----------------G-----DA---YYD------------------------------ CLK1_Hsap ----------------E-----PG---HRQ------------------------------ Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis NSNNNYNNDYDYNDGKR-----AN---IYS------------------------------ 22369_Tthe ----------------------RK---YHH------------------------------ CLK_Spur ----------------G-----EV---TTT------------------------------ CC1G_01467_Ccin --------------------------QYHY------------------------------ CC1G_10232_Ccin ------------------------------------------------------------ CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin ---------------------------TRA------------------------------ AqueK109_Aque ------------------------------------------------------------ CLK_a_Smoe ---------------------VPK---T-------------------------------- CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ----------------------PV---T-------------------------------- GK028_Glam ------------------------------------------------------------ Doa_Dmel -------R--------R-------------------------------R--KER--SKRS CLK4_Mmus -------R--------D-------------------------------V--EST--YRIH CLK3_Mmus -------S--------S-------------------------------R--SRH--RRRS CLK2_Mmus -------T--------D-------------------------------F--RQS--YEYH CLK1_Mmus -------G--------E-------------------------------P--GSR--YQMH E02H4.3_Cele SSNLTTTN--------N-------------------------------N--NNK--EQTD C16A11.3_Cele -------NVLSRVFQAT-------------------------------ISLRKTVQ--KL KNS1_Scer ---YI------------------------------------------------T--TPKK CLK4_Hsap -------R--------D-------------------------------I--ESG--YRIH CLK3_Hsap -------P--------S-------------------------------R--SRH--RRRS CLK2_Hsap -------T--------D-------------------------------Y--RHS--YEYQ CLK1_Hsap -------R--------D-------------------------------H--ESR--YQNH Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis -------R--------NNSNNNNNSKSGNNNSNNYNHNNSNNNGGYNNY--NNG--YNNY 22369_Tthe -------S--------D-------------------------------R--SN----KFQ CLK_Spur -------I--------I-------------------------------T--SEM--TS-- CC1G_01467_Ccin -------RELRWLFDEI--------------------------------SASRKFL--KA CC1G_10232_Ccin ---------SISIFPAH--------------------------------TFIKRVSFLLH CC1G_15475_Ccin -------------------------------------------------LIERRF----- CC1G_06417_Ccin -------R--------A-------------------------------A--AEA--QAMS AqueK109_Aque ---------------------------------------------------SKK--KPRG CLK_a_Smoe -----------------------------------------------------T--YPIS CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe -----------------------------------------------------G------ GK028_Glam ------------------------------------------------------------ Doa_Dmel -H----------------------R--------------KSP-----------------A CLK4_Mmus -C----------------------S--------------KSS-----------------V CLK3_Mmus -R----------------------E--------------RAP-----------------Y CLK2_Mmus -R----------------------E--------------NSS-----------------Y CLK1_Mmus -S----------------------S--------------KSS-----------------G E02H4.3_Cele -E----------------------Q--------------RAK--------KTVNAVAAAF C16A11.3_Cele -TKCGEMSKNGNLMARKFKNQQFFS--------------KMF-----------------V KNS1_Scer FK----------------------KQRTISLPQLPLSKLSYQSNYFNVPDQTNAIVPRVT CLK4_Hsap -C----------------------S--------------KSS-----------------V CLK3_Hsap -R----------------------E--------------RGP-----------------Y CLK2_Hsap -R----------------------E--------------NSS-----------------Y CLK1_Hsap -S----------------------S--------------KSS-----------------G Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis -N----------------------N--------------NNS-----------------N 22369_Tthe KA----------------------N--------------KSY-----------------Y CLK_Spur ---------------------------------------GTK-----------------A CC1G_01467_Ccin -M---------------------------------------------------------- CC1G_10232_Ccin -T----------------------D--------------KDA-----------------V CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin -S----------------------S--------------SSS-----------------V AqueK109_Aque -F----------------------K--------------MVV-----------------G CLK_a_Smoe -K----------------------K--------------GSET----------------- CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel AS------------------------------RR-------------------------- CLK4_Mmus RS------------------------------RR-------------------------- CLK3_Mmus RT------------------------------RK-------------------------- CLK2_Mmus RS------------------------------QR-------------------------- CLK1_Mmus RS------------------------------GR-------------------------- E02H4.3_Cele ST------------QAGSGNATTVDDPASTTTSK-------------------------- C16A11.3_Cele FP------------------------------LK-------------------------- KNS1_Scer QTENELLHLTGSCAKTLEGNKAVNLTIAHS------------------------------ CLK4_Hsap RS------------------------------RR-------------------------- CLK3_Hsap RT------------------------------RK-------------------------- CLK2_Hsap RS------------------------------QR-------------------------- CLK1_Hsap RS------------------------------GR-------------------------- Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis NS------------------------------NHNSSYNNNNNNNYNNNNNNNNNNNNNN 22369_Tthe NS------------------------------NR-------------------------- CLK_Spur RT------------------------------EN-------------------------- CC1G_01467_Ccin --------------------------------SI-------------------------- CC1G_10232_Ccin KC------------------------------AI-------------------------- CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin LT------------------------------AP-------------------------- AqueK109_Aque SS------------------------------KK-------------------------- CLK_a_Smoe ----------------TL------------------------------------------ CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel ------------------------------------------------------------ CLK4_Mmus ------------------------------------------------------------ CLK3_Mmus ------------------------------------------------------------ CLK2_Mmus ------------------------------------------------------------ CLK1_Mmus ------------------------------------------------------------ E02H4.3_Cele ----------------------------------------------------------EN C16A11.3_Cele ------------------------------------------------------------ KNS1_Scer ----------------------------------------------------------TS CLK4_Hsap ------------------------------------------------------------ CLK3_Hsap ------------------------------------------------------------ CLK2_Hsap ------------------------------------------------------------ CLK1_Hsap ------------------------------------------------------------ Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNISNNSNNNNFNYNNDNDRNNSNG 22369_Tthe ------------------------------------------------------------ CLK_Spur ------------------------------------------------------------ CC1G_01467_Ccin ------------------------------------------------------------ CC1G_10232_Ccin ------------------------------------------------------------ CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin ------------------------------------------------------------ AqueK109_Aque ------------------------------------------------------------ CLK_a_Smoe ------------------------------------------------------------ CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel --------------QHKYRYRDETSH--------S--------------SSR-------R CLK4_Mmus -------------------------------------------------SSP-------K CLK3_Mmus -------------------------------------------------HAH-------H CLK2_Mmus -------------------------------------------------SSR-------R CLK1_Mmus -------------------------------------------------SSY-------K E02H4.3_Cele PAAQPPKPKSAAVQNLISQLQLPASV--------S--------------AKVDKIIACGD C16A11.3_Cele -------------------------------------------------KTF-------K KNS1_Scer PFSNPPAQ-IASL-------P-------------Q--------------SNL-------K CLK4_Hsap -------------------------------------------------SSP-------K CLK3_Hsap -------------------------------------------------HAH-------H CLK2_Hsap -------------------------------------------------SSR-------R CLK1_Hsap -------------------------------------------------SSY-------K Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis NYNNNSSN-I-----------NNNNNNNNNSNSYHNSCISYSNGGSNSKNSN-------K 22369_Tthe -------------------------------------------------SNS-------I CLK_Spur -------------------------------------------------ATV-------G CC1G_01467_Ccin -------------------------------------------------G---------T CC1G_10232_Ccin -------------------------------------------------SMH-------E CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin -------------------------------------------------APK-------K AqueK109_Aque --------------QS---VKDKESH--------Q------------------------- CLK_a_Smoe --------------------S-------------N--------------FS--------K CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------------------------ GK028_Glam ------------------------------------------------------------ Doa_Dmel R----------------------------HR----------DRAKD-------------- CLK4_Mmus R----------------------------------------KRNRP-------------- CLK3_Mmus C----------------------------HK----------RRTRS-------------- CLK2_Mmus K----------------------------HR----------RRRRR-------------- CLK1_Mmus S----------------------------K-----------HRSRH-------------- E02H4.3_Cele K----------------------------AR----------KPSRS-------------- C16A11.3_Cele F----------------------------QM----------KRTRA-------------- KNS1_Scer K----------------------------------------QIGSS-------------- CLK4_Hsap R----------------------------------------KRNRH-------------- CLK3_Hsap C----------------------------HK----------RRTRS-------------- CLK2_Hsap K----------------------------HR----------RRRRR-------------- CLK1_Hsap S----------------------------K-----------HRIHH-------------- Y111B2A.1_Cele ------------------------------------------------------------ ClkA_Ddis N----------------------------NYNNQQSNANGNHVGNS-------------- 22369_Tthe K----------------------------------------YKGQKDNQYNRQGYQQSDG CLK_Spur D----------------------------TE----------GLGDA-------------- CC1G_01467_Ccin VIYVP---------LGRDGKYIEAKTASDKR----------WWNSK-------------- CC1G_10232_Ccin KYPIPFEISSSCRGFPPDGFPLGVRWLADNT----------CWIQP-------------- CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin R----------------------------------------KRDHQ-------DEVRAPP AqueK109_Aque ------------------------------------------------------------ CLK_a_Smoe L----------------------------------------FHGRA-------------- CLK_d_Smoe ------------------------------------------------------------ CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe ------------------------------------------H----------------- GK028_Glam ------------------------------------------------------------ Doa_Dmel ----------------ERD-----------SGRNNR-Q-SQ--AKTAK---PVI----QD CLK4_Mmus ----------------CAS-----------HQSHSK-S-HR--RK-RS---RSI----ED CLK3_Mmus ----------------CSS-----------ASSRSQ-Q-SS--KR-SS---RSV----ED CLK2_Mmus ----------------SRT-----------FSRSSS-Q-HS--SR-RA---KSV----ED CLK1_Mmus ---------------HTSQ-----------HHSHGK-S-HR--RK-RS---RSV----ED E02H4.3_Cele --------------GLQAS-----------QARPKV-P-EI--VSSQR---TQH----QD C16A11.3_Cele ---------------PKEQ-----------NPSEIK-K-IR--R-KSETDNENVAGNREN KNS1_Scer ----------------LRK-----------FTSNGS-S-ES--ASSNK---SNF----KT CLK4_Hsap ----------------CSS-----------HQSRSK-S-HR--RK-RS---RSI----ED CLK3_Hsap ----------------CSS-----------ASSRSQ-Q-SS--KR-SS---RSV----ED CLK2_Hsap ----------------SRT-----------FSRSSS-Q-HS--SR-RA---KSV----ED CLK1_Hsap ---------------STSH-----------RRSHGK-S-HR--RK-RT---RSV----ED Y111B2A.1_Cele ----------------VDF-----------HGTTDK-S-FR--T---------------- ClkA_Ddis ---------------KNNE-----------SCNNTN-T-NI--EK-SN---KSM----WD 22369_Tthe TSKKYYKDNKSKQTHSSSS-----------KSSSSK-D-SF--V-SGA---SKD----RS CLK_Spur ----------------QIA-----------IQRCKS-R-HR--EEGHR---ASV----ID CC1G_01467_Ccin ---------------FSDS---------VD---RF----PQ--C-HFS---DWE----AL CC1G_10232_Ccin ---------------VNDELVLDYLIQDYEHQYAAG-Q-GK--P-SLA---TTV----YN CC1G_15475_Ccin ------------------------------------------------------------ CC1G_06417_Ccin AKKAAAGGQQSNATNAANA---------WDNRTVAA-T-DD--S-SKG---APP----CD AqueK109_Aque ----------------SSS-----------SRKEKD-EVHRVPPPITP---AKV----ED CLK_a_Smoe -------------------------------ASKGMIN-KC--NVSFH---SCH----ED CLK_d_Smoe -----------------------------------------------------R----ED CLK_b_Smoe -----------------------------------------------------S----K- CLK_c_Smoe ------------------------------------L--NV--VVPPQ---ACH----ED GK028_Glam --------------------------------SSAR-S-GA--L-GPD---TST----QN Doa_Dmel DADGHLIYHTGDILH--HRYK--------------------------------------- CLK4_Mmus DEEGHLICQSGDVLR--ARYE--------------------------------------- CLK3_Mmus DKEGHLVCRIGDWLQ--ERYE--------------------------------------- CLK2_Mmus DAEGHLIYHVGDWLQ--ERYE--------------------------------------- CLK1_Mmus DEEGHLICQSGDVLS--ARYE--------------------------------------- E02H4.3_Cele DKDGHLIYSKGDFIL--NRFT--------------------------------------- C16A11.3_Cele LPKNPILT----SSG--AQLK--------------------------------------- KNS1_Scer DKDGHYVYQENDIFGSGGRFV--------------------------------------- CLK4_Hsap DEEGHLICQSGDVLR--ARYE--------------------------------------- CLK3_Hsap DKEGHLVCRIGDWLQ--ERYE--------------------------------------- CLK2_Hsap DAEGHLIYHVGDWLQ--ERYE--------------------------------------- CLK1_Hsap DEEGHLICQSGDVLS--ARYE--------------------------------------- Y111B2A.1_Cele ------------NWG--TDLE--------------------------------------- ClkA_Ddis DENDYYKVQVGEYLN--NRYK--------------------------------------- 22369_Tthe KDAGHYKFKNGETFD-DGRYV--------------------------------------- CLK_Spur DDEGHLIYRPGDCLQ--ARYA--------------------------------------- CC1G_01467_Ccin DKSGHYIPHLVCAVH--LRFQPGRIKVIQIDYDSPLSLAFLTMLSAKDLKGVVELHWRDK CC1G_10232_Ccin GAVTLRRIEIGDFLD--KKFC--------------------------------------- CC1G_15475_Ccin --------------E--ERAS--------------------------------------- CC1G_06417_Ccin DKEGHYIIVPDDMIF--KRYR--------------------------------------- AqueK109_Aque DEDGHLIYKKGDYLD--SRYE--------------------------------------- CLK_a_Smoe DKDGHFVFELGENIT--PRYK--------------------------------------- CLK_d_Smoe DKDGHYVFELGENIT--PRYK--------------------------------------- CLK_b_Smoe ------------------------------------------------------------ CLK_c_Smoe DKDGHFVFELGENIT--PRYK--------------------------------------- GK028_Glam LEEGHINPGPNEVLG--GRYA--------------------------------------- Doa_Dmel ------IMATLGEGTFG---RVV-KVKDMER-DYCMALKIIKNVEKYR--EA-AK-LEIN CLK4_Mmus ------IVDTLGEGAFG---KVV-ECIDHGMDGLHVAVKIVKNVGRYR--EA-AR-SEIQ CLK3_Mmus ------IVGNLGEGTFG---KVV-ECLDHARGKSQVALKIIRNVGKYR--EA-AR-LEIN CLK2_Mmus ------IVSTLGEGTFG---RVV-QCVDHRRGGTQVALKIIKNVEKYK--EA-AR-LEIN CLK1_Mmus ------IVDTLGEGAFG---KVV-ECIDHKVGGRRVAVKIVKNVDRYC--EA-AQ-SEIQ E02H4.3_Cele ------IYDTLGEGTFG---KVV-RVNDSLS-DTFMALKIIKNVSKYR--EA-AK-LEVK C16A11.3_Cele ------IIAKLGEGVFG---AVY-KVVDHSN--KKYAVKLFKEEHSEV-----GEQSWAR KNS1_Scer ------VKDLLGQGTFG---KVL-KCIDNKYEPNYVAVKVIRAVDRYR--EA-AK-TELR CLK4_Hsap ------IVDTLGEGAFG---KVV-ECIDHGMDGMHVAVKIVKNVGRYR--EA-AR-SEIQ CLK3_Hsap ------IVGNLGEGTFG---KVV-ECLDHARGKSQVALKIIRNVGKYR--EA-AR-LEIN CLK2_Hsap ------IVSTLGEGTFG---RVV-QCVDHRRGGARVALKIIKNVEKYK--EA-AR-LEIN CLK1_Hsap ------IVDTLGEGAFG---KVV-ECIDHKAGGRHVAVKIVKNVDRYC--EA-AR-SEIQ Y111B2A.1_Cele ------NVSVLGEGVFG---TVF-EVADAEK-KKKFALKLFKAGHTQFGCEDWVRESELS ClkA_Ddis ------VLCTVGSGTFS---TVV-ECWDTNS-SGQVAIKIVRSAKKYT--ED-AL-VEID 22369_Tthe ------VVKHLSDGTFG---RVL-EVQDRQNGNKLYALKVIRAVERYV--DA-AQ-IETE CLK_Spur ------ITSTLGEGTFG---KVV-QCRDNMSGGAKIALKIIKNIEKYR--EA-AK-LEIN CC1G_01467_Ccin GDPRHGAVKFTGSISC-AFHKCVWTGTDMRS-RERVVVKAIALA------DD-SE-HEVT CC1G_10232_Ccin ------VY-QLG--SFSGPCQTI-RAREIRT-GRSLLLRAIRKSSVLP--DA-LF-KDLQ CC1G_15475_Ccin ------IESTIS---A-NFHKCLFKGFDHRF-GVKIIIKAIATG------TD-ER-FERK CC1G_06417_Ccin ------TVRLLGQGTFG---KVV-EAIDTQT-NNRVAIKIIRAIPKYR--DA-SK-IEVR AqueK109_Aque ------VLRTLGEGTFG---KVV-CCHDRLT-GKDVAVKIIKNVPKYR--AA-AR-IEIR CLK_a_Smoe ------IIGKMGEGTFG---RVL-ECWDRDT-QEYVAIKLIRNVQKYR--DA-AM-IEID CLK_d_Smoe ------VISKMGEGTFG---RVL-ECWDRKY-QEFVAVKVIRNVPKYR--EA-AL-IEID CLK_b_Smoe -------------SIES---NLV-VNQSRKY-QEFVAIKVIRNVPKYR--EA-TL-IEID CLK_c_Smoe ------IIGKMGEGTFG---RVL-ECWDRDT-QEYVAIKLIRNVQKYR--DA-AM-IEID GK028_Glam ------IFARLGHGTFG---RVY-ACYDKSRDDTEVAVKVIRAIDRYT--AA-GK-AEEA . :: . Doa_Dmel -------ALEKIAQKDP-HCD--------------------HLCVKM--I-DWFDYHGHM CLK4_Mmus -------VLEHLNSTDP-NSV--------------------FRCVQM--L-EWFDHHGHV CLK3_Mmus -------VLKKIKEKDK-ENK--------------------FLCVLM--S-DWFNFHGHM CLK2_Mmus -------VLEKINEKDP-DNK--------------------NLCVQM--F-DWFDYHGHM CLK1_Mmus -------VLEHLNTTDP-HST--------------------FRCVQM--L-EWFEHRGHI E02H4.3_Cele -------VLQKLAEKDP-EKK--------------------NWVIHM--G-SYFDYNGHI C16A11.3_Cele ----ETAIMKAVTAINSANLIRM------------------EDSWRI--NESVPNGFLKI KNS1_Scer -------ILQTILNNDP-QGQ--------------------FQCLLL--R-ECFDYKNHI CLK4_Hsap -------VLEHLNSTDP-NSV--------------------FRCVQM--L-EWFDHHGHV CLK3_Hsap -------VLKKIKEKDK-ENK--------------------FLCVLM--S-DWFNFHGHM CLK2_Hsap -------VLEKINEKDP-DNK--------------------NLCVQM--F-DWFDYHGHM CLK1_Hsap -------VLEHLNTTDP-NST--------------------FRCVQM--L-EWFEHHGHI Y111B2A.1_Cele IPN-YLQIMKSVAAAHHPNLIKL------------------VKSGKM--A-SVPEGYLRI ClkA_Ddis -------ILRNLEKTGNSNGKYL------------------SHCIRL--L-DSFLFKDHI 22369_Tthe -------IIRKIQAADP-ENK--------------------YRIVKL--E-STFKHGANF CLK_Spur -------VLEKINEKEG-VGK--------------------SLCVKM--Y-DWFDYHGHV CC1G_01467_Ccin RLQRLTRCLDHAK---A-KGLT--------------------LFVDILAS-EVTNVYSVV CC1G_10232_Ccin -------AVEVVSKAED-H------------------------FVRF--T-RLFQTELDT CC1G_15475_Ccin RIRRLTNALDRAANMFP-HVQS---------------------LATL--M-DYEVHPSHT CC1G_06417_Ccin -------VLQKLKERDP-LNR--------------------NKCIHL--L-HWFDHRNHI AqueK109_Aque -------VLEQIRDIVE-DGQ--------------------ELCVQL--R-DWFDYYGHI CLK_a_Smoe -------VLNELARYDR-NGS--------------------RRCVQL--K-RWFDFRNHI CLK_d_Smoe -------VLRALRKHDK-NGK--------------------RGCLQM--K-EWFDYRNHV CLK_b_Smoe -------VLKALQKHDK-NGK--------------------RGCLQM--K-EWFDYRNHV CLK_c_Smoe -------VLNELARYDR-NGS--------------------RRCVQL--K-RWFDFRNHI GK028_Glam -------VLNKIKQAAK-KAQHTGYSSSLMNSYYAKLCWNNCNLAYL--E-RSFQHNNHI : : Doa_Dmel CIVFEMLGLSVFDFLRE-------NNYEPYPLDQVRHMAYQLCYSVKFLHDNRLTHTDLK CLK4_Mmus CIVFELLGLSTYDFIKE-------NSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLK CLK3_Mmus CIAFELLGKNTFEFLKE-------NNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLK CLK2_Mmus CISFELLGLSTFDFLKD-------NNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLK CLK1_Mmus CIVFELLGLSTYDFIKE-------NSFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLK E02H4.3_Cele CLLFDLMGSSIFDFLKA-------NHYKPYPMEQTLHITWQLCNAVKFLHDNKLTHTDLK C16A11.3_Cele AISFELKGRSVFEVMDSTKGKMPAGSEISFEINAIRVMGKQLLEAMEKLESVKIVHLDLK KNS1_Scer CLVTDLYGRSIYDFMCS-------NGIARFPGSHIQAIARQLIRSVCFLHDLGIIHTDLK CLK4_Hsap CIVFELLGLSTYDFIKE-------NSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLK CLK3_Hsap CIAFELLGKNTFEFLKE-------NNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLK CLK2_Hsap CISFELLGLSTFDFLKD-------NNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLK CLK1_Hsap CIVFELLGLSTYDFIKE-------NGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLK Y111B2A.1_Cele AILMELRGKSLFSVMDSTKSE-VPNKEISFPIATIREIGAQILSAMKKLEKMEIVHLDLK ClkA_Ddis CLVFKRYGLSLYEFLKK-------NRYRPLPLSQIQNISKQLLTAIYSMHKLSLVHTDLK 22369_Tthe CMIFEKLGLSLYELLKK-------NNYIGYKIRLVQSFFKQILESVGFLHSIHLTHTDLK CLK_Spur CISFEILGLSIFDFLKD-------NNYQPYPLDQIKRMSHQLCSAVKFLHDMKITHTDLK CC1G_01467_Ccin C--LTAHGMSLRDVLDI-------KELVPLPLNQVKAFSHQILSGIQYLHTQDIIHTDIT CC1G_10232_Ccin FLVFEDEGVPLSSIIRN-------NNIATFSPRQVREIVWQTANALDFLHSHGITHGDLC CC1G_15475_Ccin FLVFKAYGKTLTEVMTM-------QQLLPLPSSQIKGIAFQILSALRFLHGEDIAHTDIK CC1G_06417_Ccin CLVSELLGMCVYDFLKE-------NDFAPFPRHHIQDFARQLFGSVAFLHELRLIHTDLK AqueK109_Aque SLTFDMLGLSVFDFLKD-------NNYHPYSLSQVRHISWQLIKAVRYLHQTRLTHTDLK CLK_a_Smoe CMVFEKLGPSLYDFLRK-------NEYRPYAIDLVREFGRQLLESVAYMHDLTLIHTDLK CLK_d_Smoe CIVSEKLGPSLYDFLKK-------NSYRPFSIEHVRDIGWQLLNSVAYLHELSLIHTDLK CLK_b_Smoe CIVSEKLGPSLYDFLKK-------NSYRPFSIE---HVGWQLLNSVAYLHELSLIHTDLK CLK_c_Smoe CMVFEKLGPSLYDFLRK-------NEYRPYAIDLVREFGRQLLESVAYMHDLTLIHTDLK GK028_Glam CLVFPKYGISLLDLLKA-------NNFRGFNIDWTRELSRSFMVGVGFLHDLGYIHTDIK * ..: . . .: :. * *: Doa_Dmel PENILFVDSDYT--SHY-NHK--I------------------------------------ CLK4_Mmus PENILFVKSDYV--VKY-NSK--M------------------------------------ CLK3_Mmus PENILFVNSEFE--TLY-NEH--K------------------------------------ CLK2_Mmus PENILFVNSDYE--LTY-NLE--K------------------------------------ CLK1_Mmus PENILFVKSDYT--EAY-NPK--M------------------------------------ E02H4.3_Cele PENILFVDSRYT--TKL-VDK--K------------------------------------ C16A11.3_Cele PENICFSSSCTFK--T----TV-------------------------------------- KNS1_Scer PENILICDETHI--AQKLPLKTVQSL---------------------------------- CLK4_Hsap PENILFVKSDYV--VKY-NSK--M------------------------------------ CLK3_Hsap PENILFVNSEFE--TLY-NEH--K------------------------------------ CLK2_Hsap PENILFVNSDYE--LTY-NLE--K------------------------------------ CLK1_Hsap PENILFVQSDYT--EAY-NPK--I------------------------------------ Y111B2A.1_Cele PENICFTSTCTFT--T----EI-------------------------------------- ClkA_Ddis PENILLESSRFT--YFD-NSIPLQFKNSI------------------------------- 22369_Tthe PENILLASPELR--LVV-ENNSQKDSPSTQ-YQSSDKTNATAGTVSENNQKNEHQNNSTG CLK_Spur PENILFVDSRSS--IKY-DPV--K------------------------------------ CC1G_01467_Ccin PSNVVLVQDDIT--CYQ-EYTA-------------------------------------- CC1G_10232_Ccin PSNIKLSSIATVQEVYF-DWES-------------------------------------- CC1G_15475_Ccin PDNIVLVDDAVA--SYE-DFQN-------------------------------------- CC1G_06417_Ccin PENILLVHNDYR--TIN-VPIP-G------------------------------------ AqueK109_Aque PENILFVSSDYD--MYY-DAR--K------------------------------------ CLK_a_Smoe PENILLVSPDHV--KVP-DFKGLY------------------------------------ CLK_d_Smoe PENILLVSSAYV--KTL-DYKVAHFVRSFLVLL--------------------------- CLK_b_Smoe PENILLVSSAYV--KTL-DYKVVHFVRSFLVIL--------------------------- CLK_c_Smoe PENILLVSPDHV--KVP-DFKGLY------------------------------------ GK028_Glam LENILSREKPRA--TRV-R----------------------------------------- .*: Doa_Dmel ---------------------N-----------------REVRRVKNTDVRLIDFGSATF CLK4_Mmus ---------------------K-----------------RDERTLKNTDIKVVDFGSATY CLK3_Mmus ---------------------S-----------------CEEKSVKNTSIRVADFGSATF CLK2_Mmus ---------------------K-----------------RDERSVKSTAVRVVDFGSATF CLK1_Mmus ---------------------K-----------------RDERTIVNPDIKVVDFGSATY E02H4.3_Cele ---------------------V---GKFVLRRFKIDDCFQPLRVLHSTHVRLIDFGSATF C16A11.3_Cele ------------------------TG---------N--VCFIQ-PSIFHVCVVDFGNART KNS1_Scer -------------------SKRRREA---------S--KGKRKILKNPEIKIIDFGSAIF CLK4_Hsap ---------------------K-----------------RDERTLKNTDIKVVDFGSATY CLK3_Hsap ---------------------S-----------------CEEKSVKNTSIRVADFGSATF CLK2_Hsap ---------------------K-----------------RDERSVKSTAVRVVDFGSATF CLK1_Hsap ---------------------K-----------------RDERTLINPDIKVVDFGSATY Y111B2A.1_Cele ------------------------RK---------D--VCYISPSEELNVCIIDFGNARK ClkA_Ddis --------------------DTTSNN---------S--VDHYCHLVDTDIVVIDFGGATF 22369_Tthe KRSSSSSSSSSSSSSSSGSHAKSSSK---------N--SKKYWVPVSDEIKIIDFGGATF CLK_Spur ---------------------K-----------------RDVRQVVNCDIRLIDFGSATF CC1G_01467_Ccin ------------------------TN---------E--VVTKHRLRSIAVKLIDLDG-YF CC1G_10232_Ccin ------------------------R----------S--FDTRKVLKSTELRVCFFGSLGV CC1G_15475_Ccin ------------------------G----------E--FVTKYLLKNISVKLVDYDDFTD CC1G_06417_Ccin ---------------------KRNGA------------TKPKKILNSTEIRLIDFGSATF AqueK109_Aque ---------------------K-----------------QDIRVVKSTDVRLIDFGSATF CLK_a_Smoe ---------------------QRSGP---------G--RCYVRVPRTSEIKLIDFGSATF CLK_d_Smoe ----------------TLFPLQSARP---------D--KHLTRTPTSAEIRLIDFGSATF CLK_b_Smoe ----------------TLFPLQSARL---------D--KHLTRTPTSAEIRLIDFGSATF CLK_c_Smoe ---------------------QRSGP---------G--RCYVRVPRTSEIKLIDFGSATF GK028_Glam -----------------------------------D--R-IFVHPSGAELVLIDLGSSVR : : .. Doa_Dmel DH---EHHSTIVSTRHYRAPEVILEL-GWSQPCDVWSIGCILFELYLGIT-LFQTHDN-- CLK4_Mmus DD---EHHSTLVSTRHYRAPEVILAL-GWSQPCDVWSIGCILIEYYLGFT-VFQTHDS-- CLK3_Mmus DH---EHHTTIVATRHYRPPEVILEL-GWAQPCDVWSIGCILFEYYRGFT-LFQTHEN-- CLK2_Mmus DH---EHHSTIVSTRHYRAPEVILEL-GWSQPCDVWSIGCIIFEYYVGFT-LFQTHDN-- CLK1_Mmus DD---EHHSTLVSTRHYRAPEVILAL-GWSQPCDVWSIGCILIEYYLGFT-VFPTHDS-- E02H4.3_Cele DH---EHHSIIVSTRHYRAPEVILEL-GWSQPCDVWSIGCILYELYTGVT-LFQTHEN-- C16A11.3_Cele IRQDKPPKYALVQTQNYRAPEIFLGL-PFSVKSDIWSFGCILSELYTGDL-LFYGNSKSD KNS1_Scer HY---EYHPPVISTRHYRAPEIVLGL-GWSFPCDIWSIACVLVELVIGES-LYPIHEN-- CLK4_Hsap DD---EHHSTLVSTRHYRAPEVILAL-GWSQPCDVWSIGCILIEYYLGFT-VFQTHDS-- CLK3_Hsap DH---EHHTTIVATRHYRPPEVILEL-GWAQPCDVWSIGCILFEYYRGFT-LFQTHEN-- CLK2_Hsap DH---EHHSTIVSTRHYRAPEVILEL-GWSQPCDVWSIGCIIFEYYVGFT-LFQTHDN-- CLK1_Hsap DD---EHHSTLVSTRHYRAPEVILAL-GWSQPCDVWSIGCILIEYYLGFT-VFPTHDS-- Y111B2A.1_Cele SNQEDLKSSEVVQTQNYRAPEIFMGL-PFSTRSDVWSFGCILSELYTGEL-LFYGNDEHD ClkA_Ddis EN---THHTAIVCSRPYRPPEIILGM-GWSYPCDIWGVGCILVELYLGYT-LFDTHNN-- 22369_Tthe ED---EHHSDIINTRQYRAPEVILGCCKWNEVSDVWSIGCIIMELYSGEL-FFPTHEK-- CLK_Spur DH---EHHSTIVSTRHYRALEVILEL-GWSQPCDVWSIGCIIFELYTGFT-LFQTHDN-- CC1G_01467_Ccin DWRVQCEPRYAAGTRGYRAPEISLGI-PWTKGIDIFSFGCTLWELHSGGA-LFNPSDD-- CC1G_10232_Ccin DNR---SRN----HDRFRSPEVVAGI-GVDYKTDIFSLGCLMKELIINRPFLYDCMDSMF CC1G_15475_Ccin LHAIP-RPRHLVGTSIYRPPEVILNM-PWSTPVDIFAFGCTIAELYLGRP-LFPHSTG-- CC1G_06417_Ccin ES---EYHSTVVCTRHYRAPEIILGL-GWSFPCDAYSLGCILVEFYTGLA-LYQTHDN-- AqueK109_Aque DD---EHHSTVVSTRHYRAPEVILEL-GWSHPCDMWSVGCIMFELYRGHT-LFQTHDN-- CLK_a_Smoe NS---HYHCSVISTRHYRAPEVILGL-GWSYSCDIWSIGCILVELCSGST-LFQTHEN-- CLK_d_Smoe EN---QHHSSIVSTRQYRAPEIILGL-GWSYACDLWSVGCILVELFSGDP-LFQTHEN-- CLK_b_Smoe EN---QHHSSIVSTRQYRAPEIILGL-GWSYACDLWSVGCILVELFSGDP-LFQTHEN-- CLK_c_Smoe NS---HYHCSVISTRHYRAPEVILGL-GWSYSCDIWSIGCILVELCSGST-LFQTHEN-- GK028_Glam LSD--HRRPSLVCTRQYRPPEAYLGL-PFDQTLDIWSCGCVIFEILTGRT-LFRTHNS-- :*. * * :. .* : * . .: Doa_Dmel --REHLAMMERILG-QIPYRMAR-KT-K-----T---------------KYF-YH-G-KL CLK4_Mmus --KEHLAMMERILG-PIPAHMIQ-KTRK-----R---------------KYF-HH-N-QL CLK3_Mmus --REHLVMMEKILG-PIPSHMIH-RTRK-----Q---------------KYF-YK-G-GL CLK2_Mmus --REHLAMMERILG-PVPSRMIR-KTRK-----Q---------------KYF-YR-G-RL CLK1_Mmus --REHLAMMERILG-PLPKHMIQ-KTRK-----R---------------RYF-HH-D-RL E02H4.3_Cele --REHLAMMERVLG-DIPLRMAK-RT-K-----T---------------KFF-IN-G-RL C16A11.3_Cele TEELQFELMQMIVQ-QPPSCAMLREAEK---IKS---------------TKIRIEN-GNV KNS1_Scer --LEHMAMMQRINGTPFPTDIID-KMFY---KSKHKLGNSPSDLNSTVIKHF-DRKTLSL CLK4_Hsap --KEHLAMMERILG-PIPQHMIQ-KTRK-----R---------------KYF-HH-N-QL CLK3_Hsap --REHLVMMEKILG-PIPSHMIH-RTRK-----Q---------------KYF-YK-G-GL CLK2_Hsap --REHLAMMERILG-PIPSRMIR-KTRK-----Q---------------KYF-YR-G-RL CLK1_Hsap --KEHLAMMERILG-PLPKHMIQ-KTRK-----R---------------KYF-HH-D-RL Y111B2A.1_Cele TEQLQFELMQLILQ-QAPSYLMMRKAAE---NKK---------------KMI-CID-GNV ClkA_Ddis --VQHLAMMEKVMG-PFPNSMSN-VS-------K---------------KYF-ND-YGTL 22369_Tthe --IEHLAMIEKVCG-PIPQWMAQ-RSDN---SVNSHFK--------VTEEHF-QQNGTYF CLK_Spur --REHLAMAERILG-NFPSWMIK-RTRK-----S---------------KYF-YH-D-RV CC1G_01467_Ccin -WTKQLRIIERFAG-KLSSNFFE-RLRI---DGS---------------PYS-KED-FKL CC1G_10232_Ccin YVRDKLWVMENILG-SFPQELAE-TIEA---KHA---------------GVF------TP CC1G_15475_Ccin -PSHQLAIIEERLG-RFPHSFID-RVNR---GGF---------------NVF-RPN-GEV CC1G_06417_Ccin --LEHLAMMEMVMG-KMPERFAR-AGAR---SKP---------------EFF-KE-GAKL AqueK109_Aque --LEHLAMMETILG-PLPVRFVR-ESRK-----S---------------KYF-WH-G-KL CLK_a_Smoe --LEHLAMMERIIG-PLPAHMIE-KADR---RAE---------------KYF-KN-KVEL CLK_d_Smoe --LEHLAMMERILG-PISRRIID-NVDR---KAQ---------------KYF-KN-GREL CLK_b_Smoe --LEHLAMMERILG-PIPRRIID-NVDR---KAQ---------------KYF-KN-GREL CLK_c_Smoe --LEHLAMMERIIG-PLPAHMIE-KADR---RAE---------------KYF-KN-KVEL GK028_Glam --VVHLCMMERLLG-PMPDTVIE-QMDIYNSKYQ---------------EFF-CR-T-KK :: : : . Doa_Dmel DWDEKSSAGRYV-R--DHCKP-------L-FLC-QL------------------------ CLK4_Mmus DWDEHSSAGRYV-R--RRCKP-------L-KEF-ML------------------------ CLK3_Mmus VWDENSSDGRYV-K--ENCKP-------L-KSY-ML------------------------ CLK2_Mmus DWDENTSAGRYV-R--ENCKP-------L-RRY-LT------------------------ CLK1_Mmus DWDEHSSAGRYV-S--RRCKP-------L-KEF-ML------------------------ E02H4.3_Cele DWVNTSADAAYV-R--DNCKP-------L-RRS-MS------------------------ C16A11.3_Cele YM-KRKSKS--S-F--EPPKP-------L-HKQ-RR------------------------ KNS1_Scer QWPEKNKRGDTI-TTEKSMKRVLQSCDRL-DIY-IS---KVLKQDYGDSLSINWNLPPEK CLK4_Hsap DWDEHSSAGRYV-R--RRCKP-------L-KEF-ML------------------------ CLK3_Hsap VWDENSSDGRYV-K--ENCKP-------L-KSY-ML------------------------ CLK2_Hsap DWDENTSAGRYV-R--ENCKP-------L-RRY-LT------------------------ CLK1_Hsap DWDEHSSAGRYV-S--RRCKP-------L-KEF-ML------------------------ Y111B2A.1_Cele YM-KKRAKS--S-F--DPPLP-------L-YKQ-RR------------------------ ClkA_Ddis NRPQNSDEIKSM-ERV---EG-------L-KQL-KE------------------------ 22369_Tthe DWPKNDTSRKSI-SN---VKN-------L-LSF-DD------------------------ CLK_Spur DWNQDNSSGRYV-C--ENCHP-------F-RYY-LD------------------------ CC1G_01467_Ccin SWRHAEDRESQM-I--QI------------------------------------------ CC1G_10232_Ccin WWRVATSSEDHF-D--DKIVE-------FVGDSDTL------------------------ CC1G_15475_Ccin DCAEPVAQHLAV-E--ER-K--------------HI------------------------ CC1G_06417_Ccin DWPKAKSTRQSK-KDVKSTRP-------L-ALT-ARQDVI-------------------- AqueK109_Aque DWDPESPDGRYI-R--EHCRK-------L-KRY-IL------------------------ CLK_a_Smoe NWPEGAVSRESV-RAVRKLPR-------L-RNM-IL------------------------ CLK_d_Smoe NWPDAASSLESI-RTVKRLPR-------L-KEL-VQ------------------------ CLK_b_Smoe NWPDAASSLESI-RTVKRLPR-------L-KEL-VQ------------------------ CLK_c_Smoe NWPEGAVSRESV-RAVRKLPR-------L-RNM-IL------------------------ GK028_Glam SWSLPTDLDPQERRHYEELLP-------L-ERE-ID------------------------ Doa_Dmel ------------------------SDS----EDHCELFSLIKKMLEYEPSSRITLGEALH CLK4_Mmus ------------------------CHD----EEHEKLFDLVRRMLEYDPARRITLDEALQ CLK3_Mmus ------------------------QDS----LEHVQLFDLMRRMLEFDPAQRITLAEALL CLK2_Mmus ------------------------SEA----EDHHQLFDLIENMLEYEPAKRLTLGEALQ CLK1_Mmus ------------------------SQD----AEHELLFDLIGKMLEYDPAKRITLKEALK E02H4.3_Cele ------------------------CTD----PEHVELFELIENMLMFEPLARMKLPEALQ C16A11.3_Cele ------------------------PKD----LEAIPLFDLLECILIVDPSRRPSLRDISS KNS1_Scer NWSLINSKLAWKRQTHSSSSSTTDELDKETFLFWYWFIDLLRKMFEFDPTKRITAKDALD CLK4_Hsap ------------------------CHD----EEHEKLFDLVRRMLEYDPTQRITLDEALQ CLK3_Hsap ------------------------QDS----LEHVQLFDLMRRMLEFDPAQRITLAEALL CLK2_Hsap ------------------------SEA----EEHHQLFDLIESMLEYEPAKRLTLGEALQ CLK1_Hsap ------------------------SQD----VEHERLFDLIQKMLEYDPAKRITLREALK Y111B2A.1_Cele ------------------------RND----RAAIPLFELLERILIFDPTRRLTFSEISS ClkA_Ddis ------------------------YFH----PCHDSFFDLASRLLEYQPSKRISASDALS 22369_Tthe ------------------------ILK----PEHRILGDLVRKCLIIDPNQRITCAQALQ CLK_Spur ------------------------SNA----DEHRLLFDTIEEMLEFDPFKRATLSQVLD CC1G_01467_Ccin --------------------------------RRPDLRDLLKACLQGDDRVRVGVDQALQ CC1G_10232_Ccin ------------------------PEL----IRDRDALEVIRSMTAYRPSDRPSIWVLTS CC1G_15475_Ccin ------------------------SLC----ILRPNLLDLLKLCLHHDDKKRCSAKAALQ CC1G_06417_Ccin -----------------------PPYD----HINRQFLNLVQKLLAFDPAQRITVREALA AqueK109_Aque ------------------------SAE----PEHEHLFDLITQLLTYEPRKRMTASEALK CLK_a_Smoe -----------------------QHVD----QYPNVLLDLLQGLLRYEPTERLSAKQALS CLK_d_Smoe -----------------------LHVE----HSASSLTDLLEGLLRYGASDRLTAKEALR CLK_b_Smoe -----------------------LHVE----HSASSLTDLLEGLLRYGASDRLTAKEALR CLK_c_Smoe -----------------------QHVD----QYPNVLLDLLQGLLRYEPTERLSAKQALS GK028_Glam -----------------------KYGY----GYHTSLIHLLRVMLSWDARKRFSVPECMA * Doa_Dmel HPFFDRLPPHHRVGEVSN--------K------------QPL-SSGS---------SSRE CLK4_Mmus HPFFDLL----------------------------------------------------- CLK3_Mmus HPFFAGLTPE------------------------------------E---------RSFH CLK2_Mmus HPFFACLRTEPPN---------------------------------T---------KLWD CLK1_Mmus HPFFYPLK---------------------------------------------------- E02H4.3_Cele HRYFNRLPENLKIPC------------------------------KM---------DAST C16A11.3_Cele RTFF-------------------------------------------------------- KNS1_Scer HEWFNLGILDD----------------------------------------------GIA CLK4_Hsap HPFFDLL----------------------------------------------------- CLK3_Hsap HPFFAGLTPE------------------------------------E---------RSFH CLK2_Hsap HPFFARLRAEPPN-------------------------------------------KLWD CLK1_Hsap HPFFDLLK---------------------------------------------------- Y111B2A.1_Cele ETFF-------------------------------------------------------- ClkA_Ddis HPFLFETIEND------------------------------------------------- 22369_Tthe HEFFSM------------------------------------------------------ CLK_Spur HPYFADIHYRG-----------------------------------------------NR CC1G_01467_Ccin HRFYNS------------------------------------------------------ CC1G_10232_Ccin ADYFRT------------------------------------------------------ CC1G_15475_Ccin HRFFK------------------------------------------------------- CC1G_06417_Ccin HPYFSLTIP--------------------------------------------------- AqueK109_Aque HSFFAPYHTRSSTNNPTNSSSLVAQNK------------RNL-SSQG---------SSSS CLK_a_Smoe HPFFW------------------------------------------------------- CLK_d_Smoe HPFFKE------------------------------------------------------ CLK_b_Smoe HPFFKE------------------------------------------------------ CLK_c_Smoe HPFFW------------------------------------------------------- GK028_Glam HPFFEEEPRESKQTQTSG--------RNLANDQNMGTLMRDLLSAIDRTHPRYNDLKNAV : Doa_Dmel RSHSLSR CLK4_Mmus ----KRK CLK3_Mmus SSRNPSR CLK2_Mmus SSRDISR CLK1_Mmus ----KHT E02H4.3_Cele NPRINGD C16A11.3_Cele ------K KNS1_Scer TYNNTQG CLK4_Hsap ----KKK CLK3_Hsap TSRNPSR CLK2_Hsap SSRDISR CLK1_Hsap ----KSI Y111B2A.1_Cele ------K ClkA_Ddis --CFGPI 22369_Tthe ----KFD CLK_Spur DMHSISR CC1G_01467_Ccin -----LS CC1G_10232_Ccin -----EF CC1G_15475_Ccin -----RR CC1G_06417_Ccin ----EEN AqueK109_Aque SSSSDNE CLK_a_Smoe ------H CLK_d_Smoe -----RR CLK_b_Smoe -----RR CLK_c_Smoe ------H GK028_Glam DIAFGIN