CLUSTAL W (1.83) multiple sequence alignment CG1760_Dmel_DRAK MIAA-------------------------------------------------------- DRAK2_Mmus_DRAK MSRR-------------------------------------------------------- DAPK3_Mmus_DAPK MAED-------------------------------------------------------- DAPK2_Mmus_DAPK MVQA-------------------------------------------------------- DAPK1_Mmus_DAPK M----------------------------------------------------------- K12C11.4_Cele_DAPK MTSI-------------------------------------------------------- DRAK2_Hsap_DRAK MSRR-------------------------------------------------------- DRAK1_Hsap_DRAK MIPL-------------------------------------------------------- DAPK3_Hsap_DAPK M----------------------------------------------------------- DAPK2_Hsap_DAPK MFQA-------------------------------------------------------- DAPK1_Hsap_DAPK M----------------------------------------------------------- DRAK_Spur_DRAK ME---------------------------------------------------------- DAPK_Spur_DAPK M----------------------------------------------------------- AqueK071_Aque_DAPK MPYE-------------------------------------------------------- AqueK072_Aque_DAPK NLTQNLLKIVDNGNLATLRNLLTNESVNVDATNKHGEGALHIAAGYGRLEIVKELRQFGA CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK ------------------------------------------------------------ DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK ------------------------------------------------------------ K12C11.4_Cele_DAPK ------------------------------------------------------------ DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK ------------------------------------------------------------ DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK ------------------------------------------------------------ AqueK071_Aque_DAPK ------------------------------------------------------------ AqueK072_Aque_DAPK RLDISDKQGDTPLYWASRHGHNDVVIYLCSNGVDINHQDKSGETATHVAARYGHPDVLES CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK ------------------------------------------------------------ DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK ------------------------------------------------------------ K12C11.4_Cele_DAPK ------------------------------------------------------------ DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK ------------------------------------------------------------ DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK ------------------------------------------------------------ AqueK071_Aque_DAPK ------------------------------------------------------------ AqueK072_Aque_DAPK LISFNANLDIQDNDGDTPVLCACWHGFQNIVERLILAGSSLSLTNRDGDTVLHVSSVRGN CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK ------------------------------------------------------------ DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK ------------------------------------------------------------ K12C11.4_Cele_DAPK ------------------------------------------------------------ DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK ------------------------------------------------------------ DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK ------------------------------------------------------------ AqueK071_Aque_DAPK ------------------------------------------------------------ AqueK072_Aque_DAPK YTIVRYLCEKGSDLNAVNKEGQTPLYLATKRNHLDIVQFFCEQGCNLNIQDKNGNTPLHE CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK ------------------------------------------------------------ DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK ------------------------------------------------------------ K12C11.4_Cele_DAPK ------------------------------------------------------------ DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK ------------------------------------------------------------ DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK ------------------------------------------------------------ AqueK071_Aque_DAPK ------------------------------------------------------------ AqueK072_Aque_DAPK ACKDGKLSLVHTLFAAHCKLNVCNKQGMTPLHLAALHNHIEIARHLCSAGSDLNIQDNEG CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK ------------------------------------------------------------ DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK ------------------------------------------------------------ K12C11.4_Cele_DAPK ------------------------------------------------------------ DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK ------------------------------------------------------------ DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK ------------------------------------------------------------ AqueK071_Aque_DAPK ------------------------------------------------------------ AqueK072_Aque_DAPK LTVDQLAASTGNNSLAAMLKTLHQEGMRDKCLHEITLGMVQVNKVRLLVCGAADVGKTTL CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK ------------------------------------------------------------ DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK ------------------------------------------------------------ K12C11.4_Cele_DAPK ------------------------------------------------------------ DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK ------------------------------------------------------------ DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK ------------------------------------------------------------ AqueK071_Aque_DAPK ------------------------------------------------------------ AqueK072_Aque_DAPK IGSLKARFLRSLRPTKFGGSYLGPAAYRHTFGFCVEQLNIPNAGEFSVWDFSGHKDYYLT CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK ------------------------------------------------------------ DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK ------------------------------------------------------------ K12C11.4_Cele_DAPK ------------------------------------------------------------ DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK ------------------------------------------------------------ DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK ------------------------------------------------------------ AqueK071_Aque_DAPK ------------------------------------------------------------ AqueK072_Aque_DAPK HEYFLESRNTIYIVMYNRLHSYEQQLAQVRFWLAMIKSKHRPSKFIHYGGHAGQKPFVIL CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK ------------------------------------------------------------ DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK ------------------------------------------------------------ K12C11.4_Cele_DAPK ------------------------------------------------------------ DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK ------------------------------------------------------------ DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK ------------------------------------------------------------ AqueK071_Aque_DAPK ------------------------------------------------------------ AqueK072_Aque_DAPK VQSFADNPNQLPPILFGYNMEDHFDATTSHMRTSSNGVKDRIMSVQEPKRLLQQLVGEFG CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK ----------RFD-----------------------CR-------------SVSG----- DAPK3_Mmus_DAPK ----------APV-----------------------S-------------P--ES----- DAPK2_Mmus_DAPK ----------SM------------------------------------------------ DAPK1_Mmus_DAPK ------------------------------------------------------------ K12C11.4_Cele_DAPK ----------ALQ-----------------------LLLL--------LQPYTLT----- DRAK2_Hsap_DRAK ----------RFD-----------------------CR-------------SISG----- DRAK1_Hsap_DRAK ----------EKPGSGGSSPGATSGSGRAGRGLSGPCRPP--------PPPQARG----- DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ----------SM------------------------------------------------ DAPK1_Hsap_DAPK ------------------------------------------------------------ DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK ------------------------------------------------------------ AqueK071_Aque_DAPK ----------EV------------------------------------------------ AqueK072_Aque_DAPK HHFMFTDKVFCLD-----------------------CRQPRGREIQSLRSLLGTLRQSML CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK --------LLTT------------------------------------------------ DAPK3_Mmus_DAPK --------FRRP------------------------------------------------ DAPK2_Mmus_DAPK ---------RSP------------------------------------------------ DAPK1_Mmus_DAPK ------------------------------------------------------------ K12C11.4_Cele_DAPK --------IRRS------------------------------------------------ DRAK2_Hsap_DRAK --------LLTT------------------------------------------------ DRAK1_Hsap_DRAK --------LLT------------------------------------------------- DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ---------RSP------------------------------------------------ DAPK1_Hsap_DAPK ------------------------------------------------------------ DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK ------------------------------------------------------------ AqueK071_Aque_DAPK ------------------------------------------------------------ AqueK072_Aque_DAPK KEQPWVPQLVTTLQQTLPTWRKEYSQFPVMTWEAFLLCVQEQVNPLVTPETLQLVAKALN CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK ----------------------------------------------T------------- DAPK3_Mmus_DAPK ----------------------------------------------A------------- DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK ------------------------------------------------------------ K12C11.4_Cele_DAPK ------------------------------------------------------------ DRAK2_Hsap_DRAK ----------------------------------------------T------------- DRAK1_Hsap_DRAK ----------------------------------------------E------------- DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK ------------------------------------------------------------ DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK ------------------------------------------------------------ AqueK071_Aque_DAPK ------------------------------------------------------------ AqueK072_Aque_DAPK DTGEIIYITEGKLENLLVLNPDWLGQRIFGPALAPEDSLSPQFNSVTGLISLREIRRVYP CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK --------------------------------P--------------------------- DAPK3_Mmus_DAPK --------------------------------A--------------------------- DAPK2_Mmus_DAPK --------------------------------N--------------------------- DAPK1_Mmus_DAPK ------------------------------------------------------------ K12C11.4_Cele_DAPK --------------------------------K--------------------------- DRAK2_Hsap_DRAK --------------------------------P--------------------------- DRAK1_Hsap_DRAK --------------------------------I--------------------------- DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK --------------------------------N--------------------------- DAPK1_Hsap_DAPK ------------------------------------------------------------ DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK ------------------------------------------------------------ AqueK071_Aque_DAPK ------------------------------------------------------------ AqueK072_Aque_DAPK ELDPLSVAHLMEHFELCQPVGNREAYQFPLLIRMEPLYGLWEKDPQLTVYAGIRLETSSE CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK ------------------------------------------------------------ DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK ------------------------------------------------------------ K12C11.4_Cele_DAPK ------------------------------------------------------------ DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK ------------------------------------------------------------ DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK ------------------------------------------------------------ AqueK071_Aque_DAPK ------------------------------------------------------------ AqueK072_Aque_DAPK ANIFSPSVFPRAQLHIRNIFSDDIEDQEVIFWSDGLKCCRGEVEICVRQPEPNRSIEIAV CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK --------------------------------------------------------QTPI DAPK3_Mmus_DAPK --------------------------------------------------------MSTF DAPK2_Mmus_DAPK --------------------------------------------------------METF DAPK1_Mmus_DAPK ---------------------------------------------------------TVF K12C11.4_Cele_DAPK --------------------------------------------------------MSTK DRAK2_Hsap_DRAK --------------------------------------------------------QIPI DRAK1_Hsap_DRAK --------------------------------------------------------RAVV DAPK3_Hsap_DAPK ---------------------------------------------------------STF DAPK2_Hsap_DAPK --------------------------------------------------------MEPF DAPK1_Hsap_DAPK ---------------------------------------------------------TVF DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK ---------------------------------------------------------AMF AqueK071_Aque_DAPK --------------------------------------------------------ERLV AqueK072_Aque_DAPK RGTEDCRTECFALLQQFYEILSNIILDSNPGTSFTLKVLSTRSMAEHQKNPHMYSSMEIF CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK ------------------------------------------------------------ DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK ------------------------------------------------------------ K12C11.4_Cele_DAPK ------------------------------------------------------------ DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK ------------------------------------------------------------ DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK ------------------------------------------------------------ AqueK071_Aque_DAPK ------------------------------------------------------------ AqueK072_Aque_DAPK NAERNTGVLNSPNAEIGSGESIVDLLCCGCKELEISVKSAPFTSIRDIPLKTRVELCRML CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK ------------------------------------------------------------ DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK ------------------------------------------------------------ K12C11.4_Cele_DAPK ------------------------------------------------------------ DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK ------------------------------------------------------------ DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK ------------------------------------------------------------ AqueK071_Aque_DAPK ------------------------------------------------------------ AqueK072_Aque_DAPK DPPDPFGRDWCLLALQLGVQEDVPVIDVSSDMGSPTDKLLLAWENRSHETVVMLVDALTG CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK -------------------------------------KTENFNN---------------- DAPK3_Mmus_DAPK -------------------------------------RQEDVED---------------- DAPK2_Mmus_DAPK -------------------------------------KQQKVED---------------- DAPK1_Mmus_DAPK -------------------------------------RQENVDD---------------- K12C11.4_Cele_DAPK -------------------------------------LKQNLEGSFFVVSFSACSPGSKC DRAK2_Hsap_DRAK -------------------------------------KMENFNN---------------- DRAK1_Hsap_DRAK -------------------------------------RTEPFQD---------------- DAPK3_Hsap_DAPK -------------------------------------RQEDVED---------------- DAPK2_Hsap_DAPK -------------------------------------KQQKVED---------------- DAPK1_Hsap_DAPK -------------------------------------RQENVDD---------------- DRAK_Spur_DRAK ----------------------------------------NHAS---------------- DAPK_Spur_DAPK -------------------------------------RTESVEE---------------- AqueK071_Aque_DAPK -------------------------------------RKEKLEE---------------- AqueK072_Aque_DAPK IGREDVAAELVNGLSPFSNPRNSLFVNIDVIIMSSKDVPKYVQE---------------- CG1760_Dmel_DRAK -------------------------GSRT-VGKFAAVRRAIHKNTGSHFAAKFLKRRRRA DRAK2_Mmus_DRAK ------------------FYTL-TPKELG-RGKFAVVRQCISKSTGQEYAAKSLKKRRRG DAPK3_Mmus_DAPK ------------------HYE--MGEELG-SGQFAIVRKCQQKGTGMEYAAKFIKKRRLP DAPK2_Mmus_DAPK ------------------FYD--IGEELG-SGQFAIVKKCREKSTGLEYAAKFIKKRQSR DAPK1_Mmus_DAPK ------------------YYD--TGEELG-SGQFAVVKKCREKSTGLQYAAKFIKKRRTK K12C11.4_Cele_DAPK EISCNITTFRFILYNIAPLFIA-RKQRQR-IGQFAVVRRVRDRKTGEKYAAKFIKKRRYA DRAK2_Hsap_DRAK ------------------FYIL-TSKELG-RGKFAVVRQCISKSTGQEYAAKFLKKRRRG DRAK1_Hsap_DRAK ------------------GYSLCPGRELG-RGKFAVVRKCIKKDSGKEFAAKFMRKRRKG DAPK3_Hsap_DAPK ------------------HYE--MGEELG-SGQFAIVRKCRQKGTGKEYAAKFIKKRRLS DAPK2_Hsap_DAPK ------------------FYD--IGEELG-SGQFAIVKKCREKSTGLEYAAKFIKKRQSR DAPK1_Hsap_DAPK ------------------YYD--TGEELG-SGQFAVVKKCREKSTGLQYAAKFIKKRRTK DRAK_Spur_DRAK ------------------WTLC-GVQLLGVRGRFAVVRKCKHKESNRHFAAKFVRKRKMG DAPK_Spur_DAPK ------------------FYQ--IGEDIG-SGQFSEVKKVTEKSTGKDYAGKFIRKRRST AqueK071_Aque_DAPK ------------------KYD--VGAELG-RGKFAIVKRVTEKASGEQFAAKFLRKRRGG AqueK072_Aque_DAPK ------------------NYN--VVAEIA-KGKFGVVYRCTEKATNSFVAIKVMKGRHNK *:*. * : : :. * * :: *: CG1760_Dmel_DRAK QS----SDKEIKHEIAVLMLCEGEDNIVNLNAVHETRSDTALLLELATGGELQTILDN-- DRAK2_Mmus_DRAK QD----CRAEILHEIAVLELARSCPHVINLHEVYENATEIILVLEYAAGGEIFNLCLPEL DAPK3_Mmus_DAPK SSRRGVSREEIEREVSILREIR-HPNIITLHDVFENKTDVVLILELVSGGELFDFLAE-- DAPK2_Mmus_DAPK ASRRGVCREEIEREVSILRQVL-HPNIITLHDVYENRTDVVLILELVSGGELFDFLAQ-- DAPK1_Mmus_DAPK SSRRGVSREDIEREVSILKEIR-HPNVITLHEVYENKTDVILILELVAGGELFDFLAE-- K12C11.4_Cele_DAPK TSRRGVTRQNIEREVRVLQKIRGNSNVVELHAVYETASDVIIVLELVSGGELFDHVCA-- DRAK2_Hsap_DRAK QD----CRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPEL DRAK1_Hsap_DRAK QD----CRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADR DAPK3_Hsap_DAPK SSRRGVSREEIEREVNILREIR-HPNIITLHDIFENKTDVVLILELVSGGELFDFLAE-- DAPK2_Hsap_DAPK ASRRGVSREEIEREVSILRQVL-HHNVITLHDVYENRTDVVLILELVSGGELFDFLAQ-- DAPK1_Hsap_DAPK SSRRGVSREDIEREVSILKEIQ-HPNVITLHEVYENKTDVILILELVAGGELFDFLAE-- DRAK_Spur_DRAK RD----CREDILKEIRILENSVLNQRLIGLHEVYETSTEVILVLEYASGGELHQYCVADK DAPK_Spur_DAPK ASRRGVKREDIVREVSILEELS-HDNIISLHDAFELQKEVVLILELVTGGELFHYLAE-- AqueK071_Aque_DAPK KA----CRDDIIVEVDIMRQSMGHHRIIKLREVFESPREMIIIIELATGGELFRMIA--- AqueK072_Aque_DAPK -------KDDVEREVAIMRQLS-HPNILQFIDYVPDKTSYILVTELLNGGELFDYCVT-- :: *: :: :: : . :: * ***: CG1760_Dmel_DRAK EECLTEAQARHCMREVLKALKFLHDRSIAHLDLKPQNILLAGER-IEDGLKLCDFGISRV DRAK2_Mmus_DRAK AEMVSENDVIRLIKQILEGVHYLHQNNIVHLDLKPQNILLSSI-YPLGDIKIVDFGMSRK DAPK3_Mmus_DAPK KESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKHAASPRIKLIDFGIAHR DAPK2_Mmus_DAPK KESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHE DAPK1_Mmus_DAPK KESLTEEEATEFLKQILSGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHK K12C11.4_Cele_DAPK KECLDEVEAAAFIKQILLAVRHLHSLHIVHLDIKPENVMLKQRG--DSQIKIIDFGLSRE DRAK2_Hsap_DRAK AEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSI-YPLGDIKIVDFGMSRK DRAK1_Hsap_DRAK EEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSE-SPLGDIKIVDFGLSRI DAPK3_Hsap_DAPK KESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHK DAPK2_Hsap_DAPK KESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHE DAPK1_Hsap_DAPK KESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHK DRAK_Spur_DRAK EDGFCEKDVVRLLQQILEGVHYLHSQNIAHLDLKPQNILLTSKETSESDIKLIDFGIARY DAPK_Spur_DAPK EDHVNEEVAAQFVKKILEALKHMHDRNICHLDLKPENIMLLNRN--TQNIMLIDFGLSRR AqueK071_Aque_DAPK VDPLPEDKARGVVLQLLEGVEHLHSLSIVHLDLKPENILLYRKG--QLDIRIADFGLALQ AqueK072_Aque_DAPK KDYVEEAEAVFFMKQILSGLEYMHKRDICHLDLKPENIVLKDES--AKELKIIDFGTCQH : . * . : ::* .: .:* : *:*:**:*::* : : *** . CG1760_Dmel_DRAK VCEGINVREMAGTPDYVAPEVLQYEPLSLLTDIWSVGVL--------------------- DRAK2_Mmus_DRAK IGNASELREIMGTPEYLAPEILNYDPITTATDMWNIGII--------------------- DAPK3_Mmus_DAPK IEAGSEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVI--------------------- DAPK2_Mmus_DAPK IEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVI--------------------- DAPK1_Mmus_DAPK IDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVI--------------------- K12C11.4_Cele_DAPK IEPGAVVKDMVGTPEFVAPEVVNYEALSPATDMWAVGVV--------------------- DRAK2_Hsap_DRAK IGHACELREIMGTPEYLAPEILNYDPITTATDMWNIGII--------------------- DRAK1_Hsap_DRAK LKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVL--------------------- DAPK3_Hsap_DAPK IEAGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVI--------------------- DAPK2_Hsap_DAPK IEDGVEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVI--------------------- DAPK1_Hsap_DAPK IDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVI--------------------- DRAK_Spur_DRAK LNQGEEIRDIQGTPDYVAPEILNYDPITLSTDMWSIGVL--------------------- DAPK_Spur_DAPK IKPGEDIRDIMGTAEFVAPEIINFEPLSLNTDMWPVFISSRLPNIQLIQLSRSQVIQLVC AqueK071_Aque_DAPK IAPGEQVKTLVGTAEYVAPEILNYEPLSVAADMWSIGAL--------------------- AqueK072_Aque_DAPK LTKDKAVKALAGTPEFVAPEVLNYDPVTCAADMWAIGVI--------------------- : .: : **.:::***::.::.: :*:* : CG1760_Dmel_DRAK ----------------------------------------------TYVLLSGFSPFGGD DRAK2_Mmus_DRAK ----------------------------------------------AYMLLTHTSPFVGE DAPK3_Mmus_DAPK ----------------------------------------------TYILLSGASPFLGE DAPK2_Mmus_DAPK ----------------------------------------------TYILLSGASPFLGD DAPK1_Mmus_DAPK ----------------------------------------------TYILLSGASPFLGD K12C11.4_Cele_DAPK ----------------------------------------------TYILLSGGSPFLGD DRAK2_Hsap_DRAK ----------------------------------------------AYMLLTHTSPFVGE DRAK1_Hsap_DRAK ----------------------------------------------TYVMLTGISPFLGN DAPK3_Hsap_DAPK ----------------------------------------------TYILLSGASPFLGE DAPK2_Hsap_DAPK ----------------------------------------------TYILLSGASPFLGD DAPK1_Hsap_DAPK ----------------------------------------------TYILLSGASPFLGD DRAK_Spur_DRAK ----------------------------------------------TYVMLTGISPFAGD DAPK_Spur_DAPK VFISPKMGHRREQLALRKMSKALRSDWEHGETALHLAAGYGHVDILEYLQAKGASIDVAD AqueK071_Aque_DAPK ----------------------------------------------TYALLTGYSPFQGE AqueK072_Aque_DAPK ----------------------------------------------AFCLLTGCSPFLGD : . * .: CG1760_Dmel_DRAK TKQETFLNISQCALTFP----DNLFGGVSPVAIDFIRRALRIKPNDRMNATGCLDHIWLK DRAK2_Mmus_DRAK DNQETYLNISQVNVDYS----EEMFSSVSQLATDFIQSLLVKNPEKRPTAESCLSHSWLQ DAPK3_Mmus_DAPK TKQETLTNISAVNYDFD----EEYFSSTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIK DAPK2_Mmus_DAPK TKQETLANITAVSYDFD----EEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT DAPK1_Mmus_DAPK TKQETLANVSAVNYDFE----EEFFRNTSTLAKDFIRRLLVKDPKKRMTIQDSLQHPWIK K12C11.4_Cele_DAPK NRDETFSNITRVRYHFS----DRYFKNTSKHAKDFIYRLFVRDVDQRATVEECLQHPWIR DRAK2_Hsap_DRAK DNQETYLNISQVNVDYS----EETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQ DRAK1_Hsap_DRAK DKQETFLNISQMNLSYS----EEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWLT DAPK3_Hsap_DAPK TKQETLTNISAVNYDFD----EEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIK DAPK2_Hsap_DAPK TKQETLANITAVSYDFD----EEFFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT DAPK1_Hsap_DAPK TKQETLANVSAVNYEFE----DEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIK DRAK_Spur_DRAK TKQETFLNISQLNLDFA----EEDFSCHSPEARDFIQSLCVIDAEKRLSAKECLDHPWIQ DAPK_Spur_DAPK KTGETPLHVA-------------------------------------------------- AqueK071_Aque_DAPK THSDTFCNVSMCEYDFE----DEVFDEVSQEAKDFIEELLQKKPSDRLTATKCLSHPWMK AqueK072_Aque_DAPK NDAETIQNVTEGEFEFPESDPEEGYDDITDAAKDFISSLLISDPRKRLTSIDAQEHKWIN :* ::: CG1760_Dmel_DRAK DDCSLDRQIYLQPQSDAEEEEE-------------------------------------- DRAK2_Mmus_DRAK QWDFG---SLFHPEET-SG----------------------------------------- DAPK3_Mmus_DAPK VRRRE---DG------ARKPE--------------------------------------- DAPK2_Mmus_DAPK PVDTQ---QAMVRRESVVNLEN-------------------------------------- DAPK1_Mmus_DAPK PKDTQ---QALSRKASAVNMEK-------------------------------------- K12C11.4_Cele_DAPK GPEGN---AIDIRKASCITISH-------------------------------------- DRAK2_Hsap_DRAK QWDFE---NLFHPEET-SS----------------------------------------- DRAK1_Hsap_DRAK QSSIQ---EPSFRMEKALE----------------------------------------- DAPK3_Hsap_DAPK AIRRR---NVR-GEDSGRKPE--------------------------------------- DAPK2_Hsap_DAPK PVDNQ---QAMVRRESVVNLEN-------------------------------------- DAPK1_Hsap_DAPK PKDTQ---QALSRKASAVNMEK-------------------------------------- DRAK_Spur_DRAK KFSSM---PVTRVLDDNEN----------------------------------------- DAPK_Spur_DAPK ------------------------------------------------------------ AqueK071_Aque_DAPK NHSPT---VLPTSS-TVSSSSHSSAPQSQCLHSSTSSLDSALCLDSNNSSLDPSPSSSAS AqueK072_Aque_DAPK GSTSQ---AARINTER-------------------------------------------- CG1760_Dmel_DRAK --------EDVDDDVEDEEEEE-------------------------------------- DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK ---------------------RRRLRAA-RLR---EYSLK--------------SHSSMP DAPK2_Mmus_DAPK ---------------FKKQYVRRRWKLSFSIVSLCNHLTR---------SLM--KKVHLR DAPK1_Mmus_DAPK ---------------FKKFAARKKWKQSVRLISLCQRLSR---------SFL--SRSNMS K12C11.4_Cele_DAPK ---------------IQSFKTRQRWKRCVELVMVLLKASK---------SS--------- DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK ---------------------RRRLKTT-RLK---EYTIK--------------SHSSLP DAPK2_Hsap_DAPK ---------------FRKQYVRRRWKLSFSIVSLCNHLTR---------SLM--KKVHLR DAPK1_Hsap_DAPK ---------------FKKFAARKKWKQSVRLISLCQRLSR---------SFL--SRSNMS DRAK_Spur_DRAK ---------------VTQQ---DKYD---------------------------------- DAPK_Spur_DAPK ------------------------------------------------------------ AqueK071_Aque_DAPK SSFAPRPSGRSGDD-DEQEDMKKQL--TEKVSKLCTEMQKVDSSNSALRVNMIGSASSIS AqueK072_Aque_DAPK ---------------LKKLRRRRKLLAAIQAVRLSVGLLR---------SFT--RHGSVS CG1760_Dmel_DRAK ------QVEEEEEETQNVEEPTTEAPQQQQQPV--------------------------- DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK RNTSYASF--E-R----------------------------------------------- DAPK2_Mmus_DAPK ---T-------------------------------------------------------- DAPK1_Mmus_DAPK VARSDDTL--D-EEDSFVMKAIIHAINDDNVPGLQHLLGSLSSYDVNQPNKHGTPPLLIA K12C11.4_Cele_DAPK RRIGDGRF--D-EEDMVASCTLI-CAEEGNLRALHKL-SALHKLL--------------- DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK PNNSYADF--E-R----------------------------------------------- DAPK2_Hsap_DAPK ---P-------------------------------------------------------- DAPK1_Hsap_DAPK VARSDDTL--D-EEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIA DRAK_Spur_DRAK ----------T-EVSSLTINVVI--QNDDNEV---------------------------- DAPK_Spur_DAPK ------------------------------------------------------------ AqueK071_Aque_DAPK SSDSNTTVRVD-EEDGGIESREMTGTSSEPEPS-------------------LTPPF--- AqueK072_Aque_DAPK VE-P-------------------------------------------------------- CG1760_Dmel_DRAK ------------------------------QQHQL------------------------- DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK ------------------------------------------------------------ DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK AGCGNIQMLQLLIKRGSRIDVQDKGGSNAIYWASRHGH---VDTLKFLNENKCPLDVKDK K12C11.4_Cele_DAPK ---------PNATRKSLKSSFSEPNGATAMHCAAKYGH---AEVFNYFHMKGGNICARDD DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK AGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGH---VDTLKFLSENKCPLDVKDK DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK ------------------------------------------------------------ AqueK071_Aque_DAPK ---------------SSQLATPTQTGSSQSFDLSRQSRMMSS------------------ AqueK072_Aque_DAPK ------------------------------------------------------------ CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK ------------------------------------------------------------ DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK SGETALHVAARYGHADVVQLLCSFGSNPDFQD--------------------------KE K12C11.4_Cele_DAPK NGDTPLHVACRFAQHTVAGYVANEKIDVDSIN--------------------------KT DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK SGEMALHVAARYGHADVAQLLCSFGSNPNIQD--------------------------KE DRAK_Spur_DRAK -------------------------VKKKGTD--------------------------EE DAPK_Spur_DAPK ---------GRYGQVEAVQYLCDQAVNSNLAD--------------------------ED AqueK071_Aque_DAPK ------------------------SPRPSMEDDTGVGKRPNSRLTTPIDELISLAPDTIE AqueK072_Aque_DAPK ------------------------------------------------------------ CG1760_Dmel_DRAK ----------------------------------AKS---GQI----------------- DRAK2_Mmus_DRAK ---------------------------------SSQ------------------------ DAPK3_Mmus_DAPK ---------------F------SRVL------EDVAAAE--------------------- DAPK2_Mmus_DAPK -------------------------------SEDLRNCES-------------------- DAPK1_Mmus_DAPK EETPLHCAAWHGYYSV------AKALCEVGCNVNIKNREGETPLLTASARGYHDI----- K12C11.4_Cele_DAPK GETALHCAVESADTRV------VRLLLQLRPRLDLPNAREETPLHVAAARGHVDC----- DRAK2_Hsap_DRAK ---------------------------------SSQ------------------------ DRAK1_Hsap_DRAK ---------------------------------EANA----------------------- DAPK3_Hsap_DAPK ---------------F------SKVL------EEAAAAE--------------------- DAPK2_Hsap_DAPK -------------------------------DEDLRNCES-------------------- DAPK1_Hsap_DAPK EETPLHCAAWHGYYSV------AKALCEAGCNVNIKNREGETPLLTASARGYHDI----- DRAK_Spur_DRAK NDNY-----------------------------LENR------T---------------- DAPK_Spur_DAPK GETPLHIAAWHGYTSI------VQTLCKAGATLDLKNKDGETTLLCAAARGHLDI----- AqueK071_Aque_DAPK K--------------MKKLERLKRKK------DEAQQ--GEEP------KGRQALTKTLS AqueK072_Aque_DAPK -------------------------------APDRRMTEP-------------------- CG1760_Dmel_DRAK ---------------------------------HSKP--THNGHH--------------- DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK ------------------QGLRELQRGRRQC----------------------------- DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK --VECLAEHGADLNASDKDGHIALHLAVRRCQMEVIKTLLGHGSFVDFQDRHGN----TP K12C11.4_Cele_DAPK --VQALLDANSPIDAVEQDGKTALIIALENGNVDIASILITNGCDINHADHHGD----TA DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK ------------------EGLRELQRSRRLC----------------------------- DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK --VECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGN----TP DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK --VKILVEAGALLNTIDKHGITPLHHAVRRQHYDIVKYLVDSNCDVNLQDKLGD----TP AqueK071_Aque_DAPK TGQSCISPRGSDRRIS-------SPASIKNQK-LSIK--AQEGSFAEEEEARGAEDTQKP AqueK072_Aque_DAPK ------------------------------------------------------------ CG1760_Dmel_DRAK --RANSGGSISKIPIATSKLQSTPS----SETTTAIHTLTSNSN---------------- DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK --------------------RE-----------------------------------RVC DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK LHVACKDGS---APIVVALCEASCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGANVE K12C11.4_Cele_DAPK LHIASKHGL---LQAVQTLCHCAVTVDSVNANKKTALHLAAHYGHVDIIRVLLLARADVT DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK --------------------HE-----------------------------------DVE DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK LHVACKDGN---MPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVE DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK LNVACKEGA---LDLVEMLHAVGAKRDILNRHKNSALHMAARGGHIEVVRYLCLAGALIH AqueK071_Aque_DAPK SNSPTNTGSTPTVPNVAADAKAKDN----NEISSTAKELAASST---------------A AqueK072_Aque_DAPK ------------------------------------------------------------ CG1760_Dmel_DRAK -----GHVHKPTQIVTPTRRASDSDKENTYTATFVKKP---------------------- DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK ALR-----------------AAAEQREARCRDGS--A----------------------- DAPK2_Mmus_DAPK -----------------------DTEENIAR----------------------------- DAPK1_Mmus_DAPK ALT-----------------SDGKTAEDLAKAEQ-HE-HVAG------------------ K12C11.4_Cele_DAPK LRG-----------------DDGLTAELVAVAAE-RL-EAHS------------------ DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK ALA-----------------AIYEEKEAWYREES--D----------------------- DAPK2_Hsap_DAPK -----------------------DTEEDIAR----------------------------- DAPK1_Hsap_DAPK ALT-----------------TDGKTAEDLARSEQ-HE-HVAG------------------ DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK QRN-----------------QDGLTASQLASLEG-HE-DVAD------------------ AqueK071_Aque_DAPK KKSTASS--TAKE-LT----ASSTAKESATTSTT-KESAVTGSVPDTAKTSNEKALEATA AqueK072_Aque_DAPK -----------------------S------------------------------------ CG1760_Dmel_DRAK ---------------VATIQLGSSNGIEDATVVATL-----TLFPD--APTTPKVIRKTP DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK ------------------------------------------------------------ DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK ----LLARLRKD-------TH--------------RGLFIQQLRPT--QNLQPRIKLKLF K12C11.4_Cele_DAPK ----LLKMVKSQ-------EI--------------REEYISQLYPL--DTSLRRIKLKLL DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK ----LLARLRKD-------TH--------------RGLFIQQLRPT--QNLQPRIKLKLF DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK ----VLTQVEGD-------KS--------------KDLFINQLNST--SGPLHRIRIKVL AqueK071_Aque_DAPK PTSTKNAKIQKDYADKISFTL--------------NSQFVEARRSPKVLNVKPAIDKKVI AqueK072_Aque_DAPK ------------------------------------------------------------ CG1760_Dmel_DRAK TGESNGSATSVK--------------------ALVKKFQLEDSS---------------- DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK ------------------------------------------------------------ DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK GHSGSGKSTLVESLKCGL-LRS--FFRRRRPRLS----------STNSTRFPPSPLAAK- K12C11.4_Cele_DAPK GHSQSGKTRLVQTLHSSRGISS--FLESVTRRIS----------DH------YSPSSSM- DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK GHSGSGKTTLVESLKCGL-LRS--FFRRRRPRLS----------STNSSRFPPSPLASK- DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK GQSGVGKTALIDSLKCGY-FRG--LFRRSRSNISLIGSSSNGRSSPRSPRSPRSPLTPMF AqueK071_Aque_DAPK FFSQGGADQSITGSGGGIEKRSPSSFKR--DILLSKTPKQDDEKPRSKSETPSSPIVSS- AqueK072_Aque_DAPK ------------------------------------------------------------ CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK ------------------------------------------------------------ DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK ---------------------------------P----TVSVSINN------LY------ K12C11.4_Cele_DAPK ------------------------------------------KDDGIHSTNGSF------ DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK ---------------------------------P----TVSVSINN------LY------ DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK GNGKKMDGGRFFMESLKRKQLSSTSSSFDVDSEV----TRGIEFTH-----GTIPGAGDF AqueK071_Aque_DAPK ---------------------------------KDFAPPPSRSIKS------CS------ AqueK072_Aque_DAPK ------------------------------------------------------------ CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK ------------------------------------------------------------ DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK ---------------------PGCENVSVRS-RSMMFEPGLTKGML-------------- K12C11.4_Cele_DAPK --------------------------VSESN-NNSSFDL--------------------- DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK ---------------------PGCENVSVRS-RSMMFEPGLTKGML-------------- DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK TFLEFSGEDTYHTAYPHFLSDEGAIHLVVFS-LDDMFEEQLAQVTYWMNFLRSQLPATEP AqueK071_Aque_DAPK ---------------------PVSTTMTEVKRRAKK------------------------ AqueK072_Aque_DAPK ------------------------------------------------------------ CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK ------------------------------------------------------------ DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK -----------EVF---------------------------------------------- K12C11.4_Cele_DAPK ------------------------------------------------------------ DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK -----------EVF---------------------------------------------- DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK VGYCGKYRQQPKIALVATHADHTQCPKQPTGELISGEGNIVLYQTKRLFGRLFDICDVLF AqueK071_Aque_DAPK ------------------------------------------------------------ AqueK072_Aque_DAPK ------------------------------------------------------------ CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK ------------------------------------------------------------ DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK ------------------------------------------------------------ K12C11.4_Cele_DAPK ------------------------------------------------------------ DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK ------------------------------------------------------------ DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK VMDANSAQSKDVKMLRTHISSLRNSILKDKSKDLFINQLNSTSGPLHRIRIKVLGQSGVG AqueK071_Aque_DAPK ------------------------------------------------------------ AqueK072_Aque_DAPK ------------------------------------------------------------ CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK ------------------------------------------------------------ DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK ------------------------------------------------------------ K12C11.4_Cele_DAPK ------------------------------------------------------------ DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK ------------------------------------------------------------ DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK KTALIDSLKCGYFRGLFRRSRSNISLIGSSSNGRSSPRSPRSPRSPLTPMFGNGKKMDGG AqueK071_Aque_DAPK ------------------------------------------------------------ AqueK072_Aque_DAPK ------------------------------------------------------------ CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK ------------------------------------------------------------ DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK ----------VAPSHHLHCSTDDQSTKAIDIQNAYLNGVGDFSVWEFSGNPVYFCCYDYF K12C11.4_Cele_DAPK ----------AAAAGSKYAPPHSQYTRGIDVQTVNINGCGEFSVWEFGGYEPMHTCYDHF DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK ----------VAPTHHPHCSADDQSTKAIDIQNAYLNGVGDFSVWEFSGNPVYFCCYDYF DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK RFFMESLKRKQLSSTSSSFDADSEVTRGIEFTHGTIPGAGDFTFLEFSGEDTYHTAYPHF AqueK071_Aque_DAPK --------------------------------------TQDRKSW--------------- AqueK072_Aque_DAPK ------------------------------------------------------------ CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK ------------------------------------------------------------ DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK AANDPTSIHIIVFSLEEPYEIQLNQVIFWLSFLKSLVPVEEPIAFGGKLKNPLRVVLVAT K12C11.4_Cele_DAPK VGN-ADCIHLILYRTSDPTEVQYKQILYWMNFLKGRVTPFEPIGHCGFSSRRSKVIIVGT DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK AANDPTSIHVVVFSLEEPYEIQLNQVIFWLSFLKSLVPVEEPIAFGGKLKNPLQVVLVAT DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK LSD-EGAIHLVVFSLDDMFEEQLAQVTYWMNFLRSQLPATEPVGYCGKYRQQPKIALVAT AqueK071_Aque_DAPK --------------------------------------------------------RNTP AqueK072_Aque_DAPK ------------------------------------------------------------ CG1760_Dmel_DRAK ----------------------------------------GS------------------ DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK ------------------------------------------------------------ DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK HADIMNIPRP-AGGEFGYDKDTSLLKEIRNRFGNDLHVSNKLFVLDAGASGSKDIKVLRN K12C11.4_Cele_DAPK HATSSLFPQMNQEGEYVSSDIEAMLNTVRLRFETHFDMDHRLILLDATNPSCIGMKTLKM DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK HADIMNVPRP-AGGEFGYDKDTSLLKEIRNRFGNDLHISNKLFVLDAGASGSKDMKVLRN DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK HADHTQCPKQ-PTGEMISGEGNIVLYQTKRLFGRLFDICDVLFVMDANSAQSKDVKMLRT AqueK071_Aque_DAPK HIDPDVIEA-MLRGEFDIDDDESSSEAKLETMKEEVEPRNES------------------ AqueK072_Aque_DAPK ------------------------------------------------------------ CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK ---------------------------------------IQD------------------ DAPK3_Mmus_DAPK --------------------------------------------------------GLGR DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK HLQEIRSQIVSGCSPMTHLCEKIISTLPSWRKLNGPNQLMSLQQFVYDVQDQLNPLASED K12C11.4_Cele_DAPK ELAKCRTNILAKLLKPLAILDTVVNHLNLVRKKHANFPVITWPDFIQLVRNEINPLTGDA DRAK2_Hsap_DRAK ---------------------------------------TQD------------------ DRAK1_Hsap_DRAK ---------------------------------------LQE---------G-------- DAPK3_Hsap_DAPK --------------------------------------------------------SLGQ DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK HLQEIRSQIVSVCPPMTHLCEKIISTLPSWRKLNGPNQLMSLQQFVYDVQDQLNPLASEE DRAK_Spur_DRAK ------------------------VEYVSPREVKSPNEQVQDSEACLDVRSG-------- DAPK_Spur_DAPK HISSLRNSILKVEAPVSVLCEAVASALPAWRRTFVNFPVLTWQQFSEGIHASINPLAGQA AqueK071_Aque_DAPK ------------------------------------------------------------ AqueK072_Aque_DAPK ------------------------------------------------------------ CG1760_Dmel_DRAK AVARRSGGAVTSSSGLH---SPTTTSV---------RLNSIRRASEPLT-----TVYKKQ DRAK2_Mmus_DRAK ---------------------------------------------------------LT- DAPK3_Mmus_DAPK D---------------------------------------------LRRLRTELGRTEA- DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK D---------------------------------------------LRRIAQQLHSTGE- K12C11.4_Cele_DAPK H---------------------------------------------CRQIVQQLQLIGE- DRAK2_Hsap_DRAK ---------------------------------------------------------HS- DRAK1_Hsap_DRAK ---------------------------------------------------------HS- DAPK3_Hsap_DAPK D---------------------------------------------LRRLRQELLKTEA- DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK D---------------------------------------------LRRIAQQLHSTGE- DRAK_Spur_DRAK ---------------------------------------------------------II- DAPK_Spur_DAPK H---------------------------------------------LREVGRQLHLMGE- AqueK071_Aque_DAPK PLAGRTGTVVLSGTKSHVSLSPTATPILKKGCFSDPHLERVTKSESPRRVVMMVSATRP- AqueK072_Aque_DAPK ------------------------------------------------------IRLST- CG1760_Dmel_DRAK TSQNGCSSTSN-PS---------------------------------------------- DRAK2_Mmus_DRAK --LR-------------------------------------------------------- DAPK3_Mmus_DAPK --LRTRAQEEA-RA---------------------------------------------- DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK --INIMQSETV-QDVLLLDPRWLCTNVLGKLLSVETPRALHHYRGRYTMEDIQRLVPDS- K12C11.4_Cele_DAPK --LVYLRNDLCDADYVVLNAEWFGTHILGQLLSAEFLS-KASPNGSYHTSSLAKIFPEIP DRAK2_Hsap_DRAK --VR-------------------------------------------------------- DRAK1_Hsap_DRAK --VP-------------------------------------------------------- DAPK3_Hsap_DAPK --LKRQAQEEA-KG---------------------------------------------- DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK --INIMQSETV-QDVLLLDPRWLCTNVLGKLLSVETPRALHHYRGRYTVEDIQRLVPDS- DRAK_Spur_DRAK --IE-------------------------------------------------------- DAPK_Spur_DAPK --VQCFGSELLQ-EVIVIEPTWLCSGIIGRLLSHDAT---EQPEGQYSIHYIQSLFPDT- AqueK071_Aque_DAPK --ETSLESSSS-PDR--------------------------------------------- AqueK072_Aque_DAPK --PPSSAPATN-PG---------------------------------------------- CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK -------------SSEEKTSKSSC------------------------------------ DAPK3_Mmus_DAPK -----------------------------ALLGAGGLKR--------------------- DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK DVEELLQILDA-MDICARDLSSGTMVDIPALIKTDSLQRSWA-----------------D K12C11.4_Cele_DAPK EQSDLMTILEV-LQLCAPDARTG-AHEFPVFIQTEAPDSIWRPYSL-------------K DRAK2_Hsap_DRAK -------------SSEDKTSKSSC------------------------------------ DRAK1_Hsap_DRAK -------------EINSDTDKSETKESI--VTEE-----------LIVVTS--------- DAPK3_Hsap_DAPK -----------------------------ALLGTSGLKR--------------------- DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK DVEELLQILDA-MDICARDLSSGTMVDVPALIKTDNLHRSWA-----------------D DRAK_Spur_DRAK ---EILSDMDVHMDVESKDGQTDTTQDLPHIQEE-----------VQVLSQYSKSFEVLD DAPK_Spur_DAPK DAMDISQLMEA-MDICVH----GTVCEIPAVMRCPAPEGIWE-----------------K AqueK071_Aque_DAPK ------------------TPPI-------------------------------------- AqueK072_Aque_DAPK -----------------------------S------------------------------ CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK --------------------------------------------------------RLCR DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK EE--DEVMVYGGVRIVPVEHLTPFPCGIFHKVQVNLCRWIHQQ-SAEGDADIRLWVSGCR K12C11.4_Cele_DAPK EK--ERDTVYGGVRILPMRGMERSLHSTFPRIQVALRRSINDY-QPAKDTQLHQWSECSK DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK --------------------------------------------------------RFSR DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK EE--DEVMVYGGVRIVPVEHLTPFPCGIFHKVQVNLCRWIHQQ-STEGDADIRLWVNGCK DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK EDENGNFRVYGGVRMQLSDCGSTLPSGLFSRIQMSLRRNFQQDMEDTTDNELVMWRNGAK AqueK071_Aque_DAPK ------------------------------------------------------------ AqueK072_Aque_DAPK ------------------------------------------------------------ CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK LENRYDALAAQVAAEVQFVRDLVRALEQERL----------------------------- DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK IANRGAELLVLLVNHGQGIEVQVRGLETEKIKCCLLLDSVCSTIETVMATTLPGLLTVKH K12C11.4_Cele_DAPK LVSQDREAVIRMV--GDAVEIRARGPSESATSMFYFMEDLINLVEHAAAEVGPGISLERH DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------------------------ DAPK3_Hsap_DAPK LENRYEALAKQVASEMRFVQDLVRALEQEKL----------------------------- DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK LANRGAELLVLLVNHGQGIEVQVRGLETEKIKCCLLLDSVCSTIENVMATTLPGLLTVKH DRAK_Spur_DRAK ------------------------------------------------------------ DAPK_Spur_DAPK CSSGSIEGLISMTNDECAIEIKVRGYNDTRQGCFIFLEDLVHLVKHVLVDSYPGLPLNME AqueK071_Aque_DAPK ------------------------------------------------------------ AqueK072_Aque_DAPK -----------------F------------------------------------------ CG1760_Dmel_DRAK ------------------------------------------------------------ DRAK2_Mmus_DRAK ------------------------------------------------------------ DAPK3_Mmus_DAPK ------------------------------------------------------------ DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK YLSPQQLREHHEPVMVYQPRDFFRAQTLKESSLT-NTMGGYKESFSSITCFGCHDVYSQA K12C11.4_Cele_DAPK FISPKHLKEHREHPALFPPESMMEMQQRESLSVK-GTQ-DEEELFTDVVCFGSRDVARHL DRAK2_Hsap_DRAK ------------------------------------------------------------ DRAK1_Hsap_DRAK ------------------------------------------YT---------------- DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK YLSPQQLREHHEPVMIYQPRDFFRAQTLKETSLT-NTMGGYKESFSSIMCFGCHDVYSQA DRAK_Spur_DRAK ----HELVEKREYPLISQPRQVII-ESLEDSPAAVSLQGESSVALGDMKCRSCNRLHPES DAPK_Spur_DAPK VLSPIQLSSHEKTIMVYNACSLLRLQLRTERTVE-NPISNQEEDFVDIFCFGSESVESNL AqueK071_Aque_DAPK ------------------------------------------------------------ AqueK072_Aque_DAPK ------------------------------------------------------------ CG1760_Dmel_DRAK -------SSPGSSPTTSG-STATL------------LIHSQRLGNSTAPASHCVAVPATA DRAK2_Mmus_DRAK -----------NGSC--G-ARE----DKENIP-----EDGSLVS---------------- DAPK3_Mmus_DAPK ------------------------------------------------------------ DAPK2_Mmus_DAPK ---------------------RK------------------------------------- DAPK1_Mmus_DAPK SLGMDIH--ASDLSL--L-TRRKLSRLLD--PPDPMGKDWCLLAMNLGL-P--DMVAKHN K12C11.4_Cele_DAPK TLGIDVG--VADLQM--A-SRCELACLLD--PPHAMGRDWSILAVKLQL-T--DQVPDVD DRAK2_Hsap_DRAK -----------NGTC--G-DRE----DKENIP-----EDSSMVS---------------- DRAK1_Hsap_DRAK -----------LGQC--R--QS----EKEKM------EQ-KAIS---------------- DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ---------------------RK------------------------------------- DAPK1_Hsap_DAPK SLGMDIH--ASDLNL--L-TRRKLSRLLD--PPDPLGKDWCLLAMNLGL-P--DLVAKYN DRAK_Spur_DRAK QSASDRSRSPSSSPM--G-TRRTLCPNKENFP-----KDIR-EP---------------- DAPK_Spur_DAPK IAGVDLH--LSEIPS--L-TRRQISMLLD--PPDPMGKDWCLLAVGLGL-T--EKIPMLD AqueK071_Aque_DAPK ------MQSPLKSPGCLSQTDATVMT-----SPE--KTHLSALQSSLSL-S--RSTPDLS AqueK072_Aque_DAPK ------------------------------------------------------------ CG1760_Dmel_DRAK TATS--SASSSNSSSGKSTSAAHHLHHHHMHHHHHH------------------------ DRAK2_Mmus_DRAK --K-RFRFDD------SLP----------------------------------------- DAPK3_Mmus_DAPK ------------------------------------------------------------ DAPK2_Mmus_DAPK ------------------------------------------------------------ DAPK1_Mmus_DAPK VNN-RA-SRD------FLPSPVHALLQEWTSY--PESTVGILISKLRELGRRDAADFLLK K12C11.4_Cele_DAPK STG-------------QSLSRTDQLLNEWAIHHPEQASVGNLCRILVELGRCDARDALYR DRAK2_Hsap_DRAK --K-RFRFDD------SLP----------------------------------------- DRAK1_Hsap_DRAK --K-RFKFEE------PLL----------------------------------------- DAPK3_Hsap_DAPK ------------------------------------------------------------ DAPK2_Hsap_DAPK ------------------------------------------------------------ DAPK1_Hsap_DAPK TSN-GA-PKD------FLPSPLHALLREWTTY--PESTVGTLMSKLRELGRRDAADFLLK DRAK_Spur_DRAK --K-RFCL--------EVV----------------------------------------- DAPK_Spur_DAPK TLNRRC-GPD------ESDSPTERLLQEWGKE--ETNSVGVLLNKVKDLGREDVLRVLMQ AqueK071_Aque_DAPK ----------TILSSGKHSKRSQGLKE--------------------------------- AqueK072_Aque_DAPK ------------------------------------------------------------ CG1760_Dmel_DRAK ---------HHHHVVIAAKNAAAV-AAT-------------------NNLSLDQGIIC DRAK2_Mmus_DRAK -----------------------------------------------SPHELVPDLFC DAPK3_Mmus_DAPK --------------------------------------------------Q-AECGVR DAPK2_Mmus_DAPK -----------------------------------------------ALHPRRRSSTS DAPK1_Mmus_DAPK ASSVFKINL-DGN------GQEAYASSCNSGT---------------SYNSISSVVSR K12C11.4_Cele_DAPK TVPLYVFAPLEDQFLLET-NDSGVVSSCHSSS-------------------EHNPINI DRAK2_Hsap_DRAK -----------------------------------------------NPHELVSDLLC DRAK1_Hsap_DRAK -------------------------------------------------QEIPGEFIY DAPK3_Hsap_DAPK --------------------------------------------------QGVECGLR DAPK2_Hsap_DAPK -----------------------------------------------ALHPRRRSSTS DAPK1_Hsap_DAPK ASSVFKINL-DGN------GQEAYASSCNSGT---------------SYNSISSVVSR DRAK_Spur_DRAK -------------------------------------------------PQQQGQVVC DAPK_Spur_DAPK GSPLYKFVP-DPR------ALEEGR-QSGSGS----------------NHSSGTVASR AqueK071_Aque_DAPK -----------DTYVT-GGGSSMFSSRKNSISRSPGIRSSLLSNLTNRSKRSSREKLK AqueK072_Aque_DAPK -----------------------------MA----------------NGSASYKLHVS