CLUSTAL W (1.83) multiple sequence alignment CG11573_Dmel MES--------------------------------------------------------- DDR2_Mmus MIP------------IPRM-------------------------PLVLLLLLLILGS-A- DDR1_Mmus MGT------------GTLS-------------------------SLLLLLLLVTIGD-AD F11D5.3_Cele MKL-------------------------------------------LLYLFGVTFHS-N- C25F6.4_Cele MQI-------------------------------------------ALVLLAIYGTT-T- DDR2_Hsap MIL------------IPRM-------------------------LLVLFLLLPILSS-A- DDR1_Hsap MGP------------EALS-------------------------SLLLLLL-VASGD-AD DDR_Spur MTE------------LT-------------------------------HLRFTAECQ-SL AqueK255_Aque M----------------------------------------------------------- AqueK256_Aque ------------------------------------------------------------ AqueK257_Aque S----------------------------------------------------------- AqueK258_Aque MNP------------VRLL----------------------------LSAILIQFSLQTK AqueK259_Aque MSD------------TSLDNSLKLTERNIHILVVALVLALFVGVLFIVL-LIVCIRY--K AqueK260_Aque MYYYLCLAVSQVMAGQANV-------------------------VFILTLLIVSVSS--Q AqueK261_Aque MAG------------QANV-------------------------VFILTLLIVSVSS--Q AqueK262_Aque MES------------TLKL----------------------------LFAVFSAAAILL- CG11573_Dmel --------------------GAIADFQITASSAHDMGNV--------GPQHARLK----- DDR2_Mmus --KAQVNPAIC-RYPLGMSGGHIPDEDITASSQWS-EST--------AAKYGRLD----- DDR1_Mmus -MKGHFDPAKC-RYALGMQDRTIPDSDISVSSSWS-DST--------AARHSRLE----- F11D5.3_Cele -TVVALELREC-SHQLGMSNRKIRDEQISASSSFDLQST--------GPQHARAH----- C25F6.4_Cele -T-NTLRIDQCGENALGMQNGDIADSQITASSSFDKQSV--------GPQNARLH----- DDR2_Hsap --KAQVNPAIC-RYPLGMSGGQIPDEDITASSQWS-EST--------AAKYGRLD----- DDR1_Hsap -MKGHFDPAKC-RYALGMQDRTIPDSDISASSSWS-DST--------AARHSRLE----- DDR_Spur -MSSVEVISTC-RYPLGMNDKAIKDEQLSASSVYE-NNTLS-----FGPQNARLH----- AqueK255_Aque ------------------------------------------------------DSLNGQ AqueK256_Aque ------------------------------------------------------------ AqueK257_Aque ----AVYDVTN-PASFDGSNLTTTDP--NCPT--L-VVCFNSTSKLINGDFGPMDSLNGQ AqueK258_Aque -VPPTNYLITP-PTSYTGSSFTSDC--TLGDARGL-TRC-PNTTRLTDNVTSEGMAF--V AqueK259_Aque KRTESVDEVLS-T-----EEKTIA------------------------------------ AqueK260_Aque -IS-TLYDVIN-SSPFNESNLTTTDPNSNCAAMNL-KNCFGNTSKLTDRDFGPMDSFNGQ AqueK261_Aque -IS-tLYDVIN-SSPFNESNLTTTDPNSNCAAMNL-KNCFGNTSKLTDRDFGPMDSFNGQ AqueK262_Aque ------FTNVS-SAPIKE------------------------------------------ CG11573_Dmel ---------------------------------IDNNGGAWCPKHMV--SRG------LT DDR2_Mmus ---------------------------------SEEGDGAWCPEIPV--QPDD-----LK DDR1_Mmus ---------------------------------SSDGDGAWCPAGPV--FPK------EE F11D5.3_Cele ---------------------------------QESGSGAWCPKNQI--NSL------SK C25F6.4_Cele ---------------------------------SELASGAWCPKPQI--NSK------SY DDR2_Hsap ---------------------------------SEEGDGAWCPEIPV--EPDD-----LK DDR1_Hsap ---------------------------------SSDGDGAWCPAGSV--FPK------EE DDR_Spur ---------------------------------LNQGAGAWCPVNAQPESS-G-----HY AqueK255_Aque LGKFFAFSQNNSRVTFQVTTST-RVSTVVLYFFNSPADGIGLPQLKV--LQSI-----SL AqueK256_Aque ------------------------------------------------------------ AqueK257_Aque LGKFFAFSQNNSRVTFQVTTST-RVSTVVLYFFNSPADGIGLPQLKV--LQSI-----SL AqueK258_Aque TDNFMGWNRS-FDLEFNFGTENFFFTRIDIYYYNNPSGGYGLPDIRT--SISRTGLEDSY AqueK259_Aque ------------------------------------------------------------ AqueK260_Aque LGRFFAFNQNDSRLTF--TAFS-AVSTVVLYFFNSPADGIGLPQLEV--ILSG-----N- AqueK261_Aque LGRFFAFNQNDSRLTF--TAFS-AVSTVVLYFFNSPADGIGLPQLEV--ILSG-----N- AqueK262_Aque -----------------------------------------------------------M CG11573_Dmel EYLQVDLLGVHLVSAIRTQGRFGKGQGQEYTE-----------AYVIEYWRPGLKKWIRW DDR2_Mmus EFLQIDLRTLHFITLVGTQGRHAGGHGIEFAP-----------MYKINYSRDG-SRWISW DDR1_Mmus EYLQVDLRRLHLVALVGTQGRHAGGLGKEFSR-----------SYRLRYSRDG-RRWMDW F11D5.3_Cele EWLQISFSVDTVITSVETQGRFDDGRGMEYAT-----------AFKIQYWRPSLNAWASY C25F6.4_Cele EFLQVTLNDTFLITSVETQGRYGNGTGREFAS-----------HYMIDYLRPG-SQWIRY DDR2_Hsap EFLQIDLHTLHFITLVGTQGRHAGGHGIEFAP-----------MYKINYSRDG-TRWISW DDR1_Hsap EYLQVDLQRLHLVALVGTQGRHAGGLGKEFSR-----------SYRLRYSRDG-RRWMGW DDR_Spur EYLQVDLLNLTVILALSTQGRWDTNFGNEYTS-----------RFRLELSRDGGKTWIRY AqueK255_Aque PPVPYFFSNNDELTLTDSQLRTVTLHLNQKLI-----------TVQIDFIFPS-NSRINW AqueK256_Aque ------------------------------------------------------------ AqueK257_Aque PPVPYFFSNNDELTLTDSQLRTVTLHLNQKLI-----------TVQIDFIFPS-NSRINW AqueK258_Aque TTVVCTFIDNSEISRSDDNVQVLSLVILTSESSPSLVLLVPYQYLRLQFIFSS-SFLATQ AqueK259_Aque NEAPYCVESAEKTTVTSPSYH-V--ERHAPLV-----------TISHDIVGME-TNQ--- AqueK260_Aque KTIPYFFSNNDELTLTDSQLRTVTLQLNQSLS-----------TFQIDFIFPV-NSKINW AqueK261_Aque KTIPYFFSNNDELTLTDSQLRTVTLQLNQSLS-----------TFQIDFIFPV-NSKINW AqueK262_Aque KPVYTFGSNTTSLPIIVSMVCMV---------------NQSIDQVELRWIH--------- CG11573_Dmel RSLQGKEVLPGNI--NT-YSEVENVLQPSVFASKVRLYPYSQYDRTVCLRAEIVGCAWEE DDR2_Mmus RNRHGKQVLDGNS--NP-YDVFLKDLEPPIVARFVRLIPVTDHSMNVCMRVELYGCVWLD DDR1_Mmus KDRWGQEVISGNE--DP-GGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLWRD F11D5.3_Cele KDDFELETIPANN--DT-EHAIRRHLDRAIIARRIRIVPVSNSTRTVCMRVEVFGCPFDD C25F6.4_Cele KNRTGHVYMDGNF--DT-TTPVIRVLDPPIVASRIRFVPSSKNTRTVCMRAEIHGCKH-E DDR2_Hsap RNRHGKQVLDGNS--NP-YDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGCVWLD DDR1_Hsap KDRWGQEVISGNE--DP-EGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLWRD DDR_Spur VQMTGEEVFVGNR--DT-NSQITVHISPPIVAQVLRIIPVVLIQTPVCMRIELYGCKWLD AqueK255_Aque FLVSEVQLFAGSPVSAPMEDIVFKDGSISVVTLGPDN---IQSSISINCTVLNNGSFHWN AqueK256_Aque ------------------------------------------------------------ AqueK257_Aque FLVSEVQLFAGSPVSAPMEDIVFKDGSISVVTLGPDN---IQSSISINCTVLNNGSFHWN AqueK258_Aque TFISEIRFFTNTDTSFPAVPIVFMSPN---QTLQPHT---VQSSLNLSCTVDNNGTFHWT AqueK259_Aque ------------------------------------------------------------ AqueK260_Aque FLVSEVQFFNDTLVPAPMEDIVFKDGSISVVTLGPDN---IQSSISINCTVLNNGSFHWN AqueK261_Aque FLVSEVQFFNDTLVPAPMEDIVFKDGSISVVTLGPDN---IQSSISINCTVLNNGSFHWN AqueK262_Aque ------------------------------------------DGITYSST-ENNSSG--- CG11573_Dmel GIVSY-SIPKGMQR-------GMDIDLSDKTYDGYEEG---D-HYVNGLGQLVDGQRGKD DDR2_Mmus GLVSY-NAPAGQQFVLPG---GSIIYLNDSVYDGAV-G---YS-MTEGLGQLTDGVSGLD DDR1_Mmus GLLSY-TAPVGQTMQLS----EVMVHLNDSTYDGYTAG---GL-QYGGLGQLADGVVGLD F11D5.3_Cele SLVFY-NVDQGDLQ-------S-GISYHDFSYDGNLAN---SPHLTGGIGKLYDGEVGKN C25F6.4_Cele GVTYYSTVPDGSRL-------D-TLDFKDSMFEDSQIYTESGIKRYGSWPANRRFRSAAS DDR2_Hsap GLVSY-NAPAGQQFVLPG---GSIIYLNDSVYDGAV-G---YS-MTEGLGQLTDGVSGLD DDR1_Hsap GLLSY-TAPVGQTMYLS----E-AVYLNDSTYDGHTVG---GL-QYGGLGQLADGVVGLD DDR_Spur HLKSY-SMPTGDTR-------GEYV-FEDDTYDGYTFE---GQ-RMNGLGQLTDGMLGHS AqueK255_Aque WLFNN-TIPITDELFVEDATRTSILNINGLSYSNEG-N---YT-CTANS----------- AqueK256_Aque ------------------------------------------------------------ AqueK257_Aque WLFNN-TIPITDELFVEDATRTSILNINGLSYSNEG-N---YT-CTANS----------- AqueK258_Aque WSGP---EVSTGDIKLADTTRTSILMISNVSADDAG-N---YT-CTAFY----------- AqueK259_Aque -------------------------------------H---YH-CLRME----------- AqueK260_Aque WLVNN-TIPITDELFIEDATRTSILYINGLSYSNEG-N---YT-CTANS----------- AqueK261_Aque WLVNN-TIPITDELFIEDATRTSILYINGLSYSNEG-N---YT-CTANS----------- AqueK262_Aque ---R---LSILNTTSSNDTSFTTTLTILPAMYTDNG-T---YY-CQVRD----------- CG11573_Dmel NFRADI-NGLGKGYEWIGWRNDTLLGRPVEIIFEFETVRNLSAVIIHTNNMFSKDVQVFV DDR2_Mmus DFTQTHEYHVWPGYDYVGWRNESATNGFIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK DDR1_Mmus DFRQSQELRVWPGYDYVGWSNQSFPTGYVEMEFEFDRLRTFQTMQVHCNNMHTLGARLPG F11D5.3_Cele NVFVNH-------HKWVGWRRKR--NGNVKLAFEFSELRNISGILIHTSNEFKKSAKAFS C25F6.4_Cele PFEKNQM-----NNSWIGWNRDT-TDGRITILFEFEEVHNFTDVVLATFG-----NRI-D DDR2_Hsap DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK DDR1_Hsap DFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPG DDR_Spur NYRLS-PYNVPQGYEWVGWRNTSHPN--PEITFEFDSLRNFTSLGFHVNNYFTNNVEIFD AqueK255_Aque ----------TA------------------------------------------------ AqueK256_Aque ------------------------------------------------------------ AqueK257_Aque ----------TA------------------------------------------------ AqueK258_Aque ----------LAFGDFVGPPNNVFN----------------------------------- AqueK259_Aque ----------DG------------------------------------------------ AqueK260_Aque ----------TV------------------------------------------------ AqueK261_Aque ----------TV------------------------------------------------ AqueK262_Aque ----------KG------NSSSNWT----------------------------------- CG11573_Dmel HAKVFFSIG-GRHFSG-EPVQFSYMPDLVLDHAR-DV----------------------- DDR2_Mmus EVQCYFRSE-ASEWEP-TAVYFPLVLDDVNPSAR-FV----------------------- DDR1_Mmus GVECRFKRGPAMAWEG-EPVRHALGGSLGDPRAR-AI----------------------- F11D5.3_Cele SATVLFSIN-GKDFSD-TIVHFNNPEDTESEVPR-WI----------------------- C25F6.4_Cele GIDVIFSQD-GKTFPLFSQISSSERQSLNNTSRRYDF----------------------- DDR2_Hsap EVQCYFRSE-ASEWEP-NAISFPLVLDDVNPSAR-FV----------------------- DDR1_Hsap GVECRFRRGPAMAWEG-EPMRHNLGGNLGDPRAR-AV----------------------- DDR_Spur AIEVQFSIR-KGHFSP-RSIYTTIRPDSDHQDAR-WI----------------------- AqueK255_Aque ------------------------------------------------------------ AqueK256_Aque ------------------------------------------------------------ AqueK257_Aque ------------------------------------------------------------ AqueK258_Aque ----------------------SIKPDMETTNSV-SLTLFINVSAEVYYDEFIVPAGNTV AqueK259_Aque ------------------------------------------------------------ AqueK260_Aque ------------------------------------------------------------ AqueK261_Aque ------------------------------------------------------------ AqueK262_Aque ----------------------SARTNL---------HLLVHL-------NTVHPTVNAT CG11573_Dmel TIKL-----------------------------------------------------HHR DDR2_Mmus TVPL-----------------------------------------------------HHR DDR1_Mmus SVPL-----------------------------------------------------GGH F11D5.3_Cele RIPV-----------------------------------------------------NNR C25F6.4_Cele RVPL-----------------------------------------------------HNR DDR2_Hsap TVPL-----------------------------------------------------HHR DDR1_Hsap SVPL-----------------------------------------------------GGR DDR_Spur TVNL-----------------------------------------------------GNR AqueK255_Aque ---------------------------------------------------------GST AqueK256_Aque ------------------------------------------------------------ AqueK257_Aque ---------------------------------------------------------GST AqueK258_Aque TVQKDTNVTLSCIFTGYLPMDYQINWMDS----SNMADGTITNGDDTRNI---SQSGGSS AqueK259_Aque ---------------------------------------------------------GVD AqueK260_Aque ---------------------------------------------------------GIV AqueK261_Aque ---------------------------------------------------------GiV AqueK262_Aque TSS--PAAELSCDMAGYVPPQSSLHWYRNGTRLTNTGRYSIVYRDGWRRAQKESKDGTS- CG11573_Dmel LGR-------YVQLHLYFA--ARWMMISEITFISA-----------------PVVGNFTD DDR2_Mmus MAS-------AIKCQYHFA--DTWMMFSEITFQSD-----------------AAMYNNSG DDR1_Mmus VGR-------FLQCRFLFA--GPWLLFSEISFISD-----------------VV-NDSSD F11D5.3_Cele IAK-------VAKIRLNFGTDSDWLFISEVNFESN-----------------HT-N--IE C25F6.4_Cele AGR-------KVRISIKFS--SDWMFLTEVHFTSA-----------------ANLTLLSE DDR2_Hsap MAS-------AIKCQYHFA--DTWMMFSEITFQSD-----------------AAMYNNSE DDR1_Hsap VAR-------FLQCRFLFA--GPWLLFSEISFISD-----------------VV-NNSSP DDR_Spur VAQ-------WLKVALVHR--GKWVLVSEVSFESE-----------------DIPD-NFD AqueK255_Aque ASK-------IIQIRISSS--TS-----------N-----------------T-ISSSSA AqueK256_Aque ------------------------------------------------------------ AqueK257_Aque ASK-------IIQIRiSSS--TS-----------N-----------------T-ISSSSA AqueK258_Aque PGPAVQSNYTILSVEVDDS--DS-----------YTCSMDGT-RLKETISLIV-INSATI AqueK259_Aque SPE-------SVT----------------------------------------------- AqueK260_Aque SPV-------TSS----------------------------------------------- AqueK261_Aque SPV-------TSS----------------------------------------------- AqueK262_Aque --SSVLGVLVISSPTVQDS--GQ-----------YQCRIEGYCHLTRSVQLTV-KNGELK CG11573_Dmel EL----ANGE---------------------------------------KQSVT---SEY DDR2_Mmus ----ALPTSP---------------------------------------MAPTT---YDP DDR1_Mmus ----TFPPAPWWPPGPPPTN------------------------FSSLELEPRG---QQP F11D5.3_Cele LLND-------------------------------------------DVVIPDSVS-YFS C25F6.4_Cele ----KIPP-------------------------------------------PSS------ DDR2_Hsap ----ALPTSP---------------------------------------MAPTT---YDP DDR1_Hsap ALGGTFPPAPWWPPGPPPTN------------------------FSSLELEPRG---QQP DDR_Spur TSTATYDTPVVGPPSAGPVDHTTVSTTDADHVIPQTGNGTQKPNLISSTKKAGG---GVS AqueK255_Aque ----SIATATGTT-NSPAFT--TTS--------------------ITVAFIPSSTIIQTT AqueK256_Aque ------------------------------------------------------------ AqueK257_Aque ----SIATATGTT-NSPAFT--TTS--------------------ITVAFIPSSTIIQTT AqueK258_Aque ----SSTPVPMTTSSTPSMS--L----------------------TSTSSAPSS---SSS AqueK259_Aque -------------------------------------------------SIPSPRVS-DE AqueK260_Aque ----IMPT-------STSTK--T----------------------QSVTPAPTG---NTS AqueK261_Aque ----IMPT-------STSTk--T----------------------QSVTPAPTG---NTS AqueK262_Aque ----DRDEMICT-EGVVDI---L----------------------NTANNG-GS---NSS CG11573_Dmel PLQRDEVGRAISSGGDLLILLI-QLLLPLIINVCSTPFMRSSHLPK--SPGRGSSPEFVV DDR2_Mmus MLKVDDSNTRILIGCLVAIIFILLAIIVIILWRQFW---Q-KMLEKAS--RRMLDDEMTV DDR1_Mmus VAKAEGSPTAILIGCLVAIILLLLLIIALMLWRLHW---R-RLLSKAE--RRVLEEELTV F11D5.3_Cele VTEH-DDGTSMF---AFIIFFFMFLIVAVIILTVLY---R-KREYRVKASSPSPNAKREI C25F6.4_Cele -----AATQQLL----VVCGIIFLTIFACVAY-CVS--------VCLK--RRQKNKSVDS DDR2_Hsap MLKVDDSNTRILIGCLVAIIFILLAIIVIILWRQFW---Q-KMLEKAS--RRMLDDEMTV DDR1_Hsap VAKAEGSPTAILIGCLVAIILLLLLIIALMLWRLHW---R-RLLSKAE--RRVLEEELTV DDR_Spur NTPAQRSPIGTVISVVVTVLLLLVLLFALLLF--LY---R-RKYIKLK--HRLPTLAFEA AqueK255_Aque PAVANGGLDTVVVGLSVSLGIVAFIIVGLILLTIVL--------VKCR--KRCANRSLQV AqueK256_Aque ------------------------------------------------------------ AqueK257_Aque PAVANGGLDTVVVGLSVSLGIVAFIIVGLILLTIVL--------VKCR--KRCANRSLQV AqueK258_Aque PSPQSGDPLPIIAGAAAAAVLLILIIIVSI--VIAV--------LYCK--RRSVSKTMVI AqueK259_Aque YDYGNGGT---------------------------------------------------- AqueK260_Aque P----SSNTGLVIGLAVTIVLIVLLVIAVIVCIIIV--------IYCK--RKQKPFIKDA AqueK261_Aque P----SSNTGLVIGLAVTIVLIVLLVIAVIVCIIIV--------IYCK--RKQKPFIKDA AqueK262_Aque G-GDNNQLLTIIIAAVAGFLGLIVIILII---IIIA--------VACH--RCRRTDVFVQ CG11573_Dmel A-TG-KVTASA------------------------------------------RNSLNAA DDR2_Mmus S-LS-LPSESSMF-NNNRSSS-----PSEQ----------------------ESNSTYDR DDR1_Mmus H-LS-VPGDTILI-NNRPGPRE---PPPYQEPRPRGTPPHSAPCVPNGSALLLSNPAYRL F11D5.3_Cele L-LT-IDGNTIKH-HVSPS--------TYQMA---------------------------- C25F6.4_Cele N-VKK--DLIITHMGNKPTCHVF---PSN------------------G---KLSNGHYEV DDR2_Hsap S-LS-LPSDSSMF-NNNRSSS-----PSEQ----------------------GSNSTYDR DDR1_Hsap H-LS-VPGDTILI-NNRPGPRE---PPPYQEPRPRGNPPHSAPCVPNGSALLLSNPAYRL DDR_Spur ---N-CNGGGATI-NNCPTIATMTTVPSR-----------------------RSNPTYQI AqueK255_Aque P-MY-KISYNITA-NNKSSFRS------------------------------EGNDETDF AqueK256_Aque ------------------------------------------------------------ AqueK257_Aque P-MY-KISYNITA-NNKSSFRS------------------------------EGNDETDF AqueK258_Aque S-----------D--S-------------------------------------NNGLYAE AqueK259_Aque ------------------SSQQ------------------------------TGREELLK AqueK260_Aque P-LRTSIKYNVTD-LGQSKEEE------------------------------AGMEQYAV AqueK261_Aque P-LRTSIKYNVTD-LGQSKEEE------------------------------AGMEQYAV AqueK262_Aque PTGGATVTYLPAA-VD-------------------------------------NNEPEVK CG11573_Dmel TLPLPSPPVPPPLE-------------------------------KYYA---------A- DDR2_Mmus IFPL-RPDYQEP--SR------------------------------L---------IRK- DDR1_Mmus LL----ATYARP--PR------------------------------G---P-----GPP- F11D5.3_Cele -RDN---------LQN-----------------------------AL---------IEK- C25F6.4_Cele A--ND-ILYARSQKST-----------------------------L----------LSV- DDR2_Hsap IFPL-RPDYQEP--SR------------------------------L---------IRK- DDR1_Hsap LL----ATYARP--PR------------------------------G---P-----GPP- DDR_Spur THPDDEPQYHVI--DN-----------------------------MM---------VES- AqueK255_Aque IPENDIPLFQRNTLTD-----------------------------VL------------- AqueK256_Aque ------------------------------------------------------------ AqueK257_Aque IPENDIPLFQRNTLTD-----------------------------VL------------- AqueK258_Aque LSKPEPPPLPSRIADNGG--------------------------YASIDIPGNGFPLNDI AqueK259_Aque PH------LPLK-GT-----------------------------CYSLEVP--------- AqueK260_Aque VHKEQPPPIPPQNFSA-----------------------------VEYDVIEL--KETN- AqueK261_Aque VHKEQPPPIPPQNFSA-----------------------------VEYDVIEL--KETN- AqueK262_Aque IED-PPPPVPMRTHSQSGSYTKSGRSAELPDLLQRSQTHQLPSSTVQYDVPTTGAPEGN- CG11573_Dmel ----------------TPV------------SS--------------------------- DDR2_Mmus ----------------LPE------------FAP-------------------------- DDR1_Mmus ----------------TPA------------WAK-------------------------- F11D5.3_Cele ----------------M------------------------------------------- C25F6.4_Cele ------------------------------------------------------------ DDR2_Hsap ----------------LPE------------FAP-------------------------- DDR1_Hsap ----------------TPA------------WAK-------------------------- DDR_Spur ----------------EDE------------L---------------------------- AqueK255_Aque ------------------------------------------------------------ AqueK256_Aque ------------------------------------------------------------ AqueK257_Aque ------------------------------------------------------------ AqueK258_Aque HSPLPPAFTPQHTSPDRPTPAQISLKP---TFLQ-------------------------- AqueK259_Aque ------------------------------------------------------------ AqueK260_Aque ----------------KPKLAQISTFA---GFQ----MI--------------------- AqueK261_Aque ----------------KPKLAQISTFA---GFQ----MI--------------------- AqueK262_Aque ----P-RVIPPERGGGGPPPVTA-RKPKRKTYYDSVNMLQSVAAASNGLPGASGISVQSV CG11573_Dmel ---------------KP----MPVAPPGSQSS-------------------GSLSSSTTA DDR2_Mmus GEE--ESGCSG-VV-KPAQ------PNGP-EGVPH----YAEADIVNLQ--GVTGGNTYC DDR1_Mmus PTN--TQACSGDYM-EPEKPGAPLLPPPPQNSVPH----YAEADIVTLQ--GVTGGNTYA F11D5.3_Cele -------------------------PMSP--IISD----YAEPDISVCS--DVT------ C25F6.4_Cele -SSKSTFSC---RAIPPTWTD-FNFPPPPEG----------------------REEHTYS DDR2_Hsap GEE--ESGCSG-VV-KPVQ------PSGP-EGVPH----YAEADIVNLQ--GVTGGNTYS DDR1_Hsap PTN--TQAYSGDYM-EPEKPGAPLLPPPPQNSVPH----YAEADIVTLQ--GVTGGNTYA DDR_Spur -DN--VSESSRIYA-EPENPTCTY--KDKHNMLQH----YAETDLINIQ--GVSGNTIYG AqueK255_Aque ----------------------------------------------------------YD AqueK256_Aque ------------------------------------------------------------ AqueK257_Aque ----------------------------------------------------------YD AqueK258_Aque PNP--MYASSENLD-RHFQPRE---YLQPTRSLPH----IADADEPRE---MGSQFNIYA AqueK259_Aque --S--LFN------------------NGA-QILR-----------------------TYS AqueK260_Aque DNA--LYD------------------KSPTVITGH----YSYA--------GDCEGDIYS AqueK261_Aque DNA--LYD------------------KSPTVITGH----YSYA--------GDCEGDIYS AqueK262_Aque PSP--HDVLSGSLQ-RQDAQNP-------PDLHPIYQDGFTEEDLAPYNVVDNDYDQIYS CG11573_Dmel ATTPTS--------GVVGVGKPHHY-------------------NLDMSAN-------FA DDR2_Mmus VPAVTM------------------------------------------------DL-LSG DDR1_Mmus VPALPP------------------------------------------------GA-VGD F11D5.3_Cele ------------ANTPLLYGIDGPY-------------------DTQKRSNPLSSMVKYS C25F6.4_Cele QPVSPE------------------------------------------------NS-SNG DDR2_Hsap VPAVTM------------------------------------------------DL-LSG DDR1_Hsap VPALPP------------------------------------------------GA-VGD DDR_Spur VPSQCM------------------------------------------------EK-LNN AqueK255_Aque IPDIPEETN------P---------------------------------PADDDDV-IYA AqueK256_Aque ------------------------------------------------------------ AqueK257_Aque IPDIPEETN------P---------------------------------PADDDDV-IYA AqueK258_Aque KPNLVPPPV------PPYRGTPDPDDGIFTDEDINPEALKRQSFNMDSSIYGGYRA-IYN AqueK259_Aque EAHIDYEK-DSNYSPPLYT-RSN-----------------------------S------- AqueK260_Aque EPQWKSEKDELNVNNPIYYGKTDPF-------------------KFTESADYIDGA-IYA AqueK261_Aque EPQWKSEKDELNVNNPIYYGKTDPF-------------------KFTESADYIDGA-IYA AqueK262_Aque EPIEPATML------------------SIS---------EREAH-DEG---LPYSA-IYD CG11573_Dmel DINEE-RANCQVQEFPRQSLVIVEKLGSGVFGELHLCETNVLNDLTE------FDSHCSA DDR2_Mmus -------KDVAVEEFPRKLLAFKEKLGEGQFGEVHLCEVEGMEKFKDKDFAL-DVSANQP DDR1_Mmus -------G-PPRVDFPRSRLRFKEKLGEGQFGEVHLCEVEDPQDLVSSDFPI-SVHKGHP F11D5.3_Cele DYGE--VYCTTLPEIARDKLICVSRIGQGEFGEVDLCQLEN------------------- C25F6.4_Cele SYKSV-RKIQALKKYPSSALLIGKAIGEGKFTMIKECIIFG------------------G DDR2_Hsap -------KDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFAL-DVSANQP DDR1_Hsap -------G-PPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPL-NVRKGHP DDR_Spur -------SRTCCPEYPRSQLNFLELLGEGMFGEVHLCEAEDIQDYIRNGFPFENKNKGER AqueK255_Aque KPK-----VNKVMRIKNESFEEIALLGTGQFGEVVLAKTIGLSL-KDLRLDKTDDDKFAT AqueK256_Aque -------------------VKIISELGVGQFGKVFLAHTTTI-----------------S AqueK257_Aque KPK-----VNKVMRIKNESFEEIALLGTGQFGEVVLAKTIGLSL-KDLRLDKTDDDKFAT AqueK258_Aque DPQPLQRSENELLEVKEKNIRELKDLGMGQFGVVVLAHTVSLSL-KQLGMSESNNDPGVS AqueK259_Aque TSSS---LNLTIIEIEPSNIVTDGTLGMGQFGQVHLAHTRGLSA-ADIGIG-TDSDRTRS AqueK260_Aque EPSK---VLNTITEVTIDNLNVIEMLGVGNFGEVILATTIDLSL-KDLRLSSTNDDRSIS AqueK261_Aque EPSK---VLNTITEVTIDNLNVIEMLGVGNFGEVILATTIDLSL-KDLRLSSTNDDRSIS AqueK262_Aque DPKPL-AAAESLLQVTSDNVIEIRKLGNGQFGQVILARTRHLSL-VDMKLSETLTDRSQS . :* * * : . CG11573_Dmel TLVAVATLRPGANDHL------RKEFRSKAKQLAQ-LSDPNVARLVGACLR--DEPICIV DDR2_Mmus VLVAVKMLRADANKNA------RNDFLKEIKIMSR-LKDPNIIRLLAVCIT--EDPLCMI DDR1_Mmus LLVAVKILRPDATKNA------RNDFLKEVKIMSR-LKDPNIIRLLGVCVQ--DDPLCMI F11D5.3_Cele RKVAVKKLHGIS-QAD------EFSFHREIRVLGS-LKHPNVVEVVGVCTI--QKPILCI C25F6.4_Cele LKCAHKSTKEEDCVHG------TRALGDEIACLLQCGRHPRIVELFGVD-----ESYNLL DDR2_Hsap VLVAVKMLRADANKNA------RNDFLKEIKIMSR-LKDPNIIHLLAVCIT--DDPLCMI DDR1_Hsap LLVAVKILRPDATKNASFSLFSRNDFLKEVKIMSR-LKDPNIIRLLGVCVQ--DDPLCMI DDR_Spur TLVAVKMLRKDASKNA------RADFMKEMKIMSQ-LRDPNIVRLLAACTE--DEPYCMI AqueK255_Aque VRVAVKKIRENQSDES------IIALKKEIKFMSQ-LDHNNVVRLLAVSAESCQEQF-IV AqueK256_Aque VLVAVKVLHSDADELE------RETFEKEVKFMSR-IKHENIIQILGVCLK--KNSF-IM AqueK257_Aque VRVAVKKIRENQSDES------IIALKKEIKFMSQ-LDHNNVVRLLAVSAESCQEQF-IV AqueK258_Aque LVVAIKRLRAEADDKM------REMFEKEVKFMAR-LRHENVVRLLGVCLS--KNAF-IM AqueK259_Aque HEVAVKFLNQNATEKD------LKCFQKEVKYMSR-LRHRNVVQILAVCWR--EEKF-IM AqueK260_Aque IKVAVKKVREDQDKMA------LEAFQKEVKFMSQ-LDHDNVVRLLAVSAESCQEQF-IV AqueK261_Aque IKVAVKKVREDQDKMA------LEAFQKEVKFMSQ-LDHDNVVRLLAVSAESCQEQF-IV AqueK262_Aque ILVAIKKLKTNAETGL------LEAFDKEVKFMSR-LNHDNVVRLLAVCTV--GEHF-IM * . : : : . .: .:... . : CG11573_Dmel QDYSHCLGDLNQFLQEHVAETS-G--------LMAKKSLSFGCLVYIATQIASGMKHLEQ DDR2_Mmus TEYME-NGDLNQFLSRHEPLSSC---------S-SDATVSYANLKFMATQIASGMKYLSS DDR1_Mmus TDYME-NGDLNQFLSARQLENKATQGLSGDTESDQGPTISYPMLLHVGAQIASGMRYLAT F11D5.3_Cele MEYME-NGDLKSYILKNP-------------------TIQTSQCISICTQLAAGLAYLES C25F6.4_Cele LEHVE-YGCIRNFWMAS------------------EAPLDTEFLVRICKDIYSAMAYLES DDR2_Hsap TEYME-NGDLNQFLSRHEPPNSS---------SSDVRTVSYTNLKFMATQIASGMKYLSS DDR1_Hsap TDYME-NGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLAT DDR_Spur VEYME-NGDLNQFLYEREGFEVGLNNCNANLSNCNKSSISVGALVYKSTQIASGMKYLSN AqueK255_Aque MEYME-NGDLNKFLMDHSFTD-SH--------PPEENELSPNILLSFCIQVANGMSYLSS AqueK256_Aque MEYME-NGDLNQYLQKFEYSPD-------------------DQVVYIALQVAGGMRYLAG AqueK257_Aque MEYME-NGDLNKFLMDHSFTD-SH--------PPEENELSPNILLSFCIQVANGMSYLSS AqueK258_Aque MEYME-NGDLNHYLRNMDLIEDIN--------PLPEGAVSLPVLIYICLQVARGMCYLAS AqueK259_Aque LEFMK-NGDLQTFLQCYKSVNMGQ--------ETYNKTLSYYKLVDMSLQIADAMRYLSS AqueK260_Aque MEYME-NGDLNQHLLNHTFTE-SH--------PPPESYLSPNILLSMCIQIANGMSYLAS AqueK261_Aque MEYME-NGDLNQHLLNHTFTE-SH--------PPPESYLSPNILLSMCIQIANGMSYLAS AqueK262_Aque MEYME-NGDLNQFLQKHTLVPDTV-------TGLGDWEITPIILLYIGVQISSGMHYLGS :. . * :. . :: .: :* CG11573_Dmel MNFVHRDLATRSCIIGPELCVKVCS-IGTVINRSAYASDYCQLEGFTGRQSQPMPIRWMA DDR2_Mmus LNFVHRDLATRNCLVGKNYTIKIAD-FG--MSRNLYSGDYYRIQGR-----AVLPIRWMS DDR1_Mmus LNFVHRDLATRNCLVGENFTIKIAD-FG--MSRNLYAGDYYRVQGR-----AVLPIRWMA F11D5.3_Cele CNFVHRDIAARNCLVDGEGNVKIAD-FG--MARSLYSQEYYKVEGK-----FVLPIRWMA C25F6.4_Cele IRIVHGHFTPNNILMDGEFHAKVCSPRG--PSHH-------------------AQLRYSA DDR2_Hsap LNFVHRDLATRNCLVGKNYTIKIAD-FG--MSRNLYSGDYYRIQGR-----AVLPIRWMS DDR1_Hsap LNFVHRDLATRNCLVGENFTIKIAD-FG--MSRNLYAGDYYRVQGR-----AVLPIRWMA DDR_Spur MNFVHRDLANRNCLVGKSYTIRIAD-FG--MSRNLYSSNYYRIEGR-----AVLPIRWMA AqueK255_Aque RNFLHRDLASRNLLVGPDYLVKVGD-FG--LSRNLYDSSYYKVSGK-----AKMPLRWMA AqueK256_Aque QNYVHRDLATRNCLVGQKFLVKIAD-FG--MSRQLYDNNYYRIRGR-----AMLPIRWMA AqueK257_Aque RNFIHRDLASRNILVGPDYIVKVGD-FG--LSRNLYDSSYYKVSGK-----AKMPIRWMA AqueK258_Aque LRFIHRDLATRNILVGQDFKVKIAD-FG--MSQNLYSDFYYRIQGR-----AILPIRWMA AqueK259_Aque CKFIHRDLAARNCLVGDNFLVKVAD-FG--LSKNLYDSCYYRLTGA-----AILPIRWMA AqueK260_Aque CNYIHRDLATRNILVGRDNVVKVGD-FG--LSRNLYDSVYYKVSGK-----AKMPIRWMS AqueK261_Aque CNYIHRDLATRNILVGRDNVVKVGD-FG--LSRNLYDSVYYKVSGK-----AKMPIRWMS AqueK262_Aque RRFVHRDLATRNCLVGKDFIVKISD-FG--MSRRLYESAYYRVQGT-----LVLPIRWMA . :* .:: .. ::. . :: . * : :*: : CG11573_Dmel WESVLLGKFTTKSDVWSFAVALWEILTFAREQPYEHLSDKSVIENIGLIYRDYKMHELLP DDR2_Mmus WESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQIYLP DDR1_Mmus WECILMGKFTTASDVWAFGVTLWEVLMLCRSQPFGQLTDEQVIENAGEFFRDQGRQVYLS F11D5.3_Cele WEALLLGKFSTASDVWGFGVTMWEIFSLCSEKPYSDMTDDDVVENLQSMSSTGSLKQVLS C25F6.4_Cele PESIVNNEFTHKSDAWAVATTVYEMAYQCRQRPYEELTNEQIVDNACALLDHQPNAVVPL DDR2_Hsap WESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLP DDR1_Hsap WECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLS DDR_Spur WESILLGKFTSKTDVWAFGVTLWEVMMLCREQPYSRLTDEQVIENTGQFFEKDGTPVYLA AqueK255_Aque KEC-FYGKFSEVTDLWAFGVTVWELYMMSRDYPYSFMTDQEVLDNALKG----FNCVLLE AqueK256_Aque KEC-FYGRFTEKTDVWAYGVVMWEIFTLCQCQPYETLNDQEVIDNALAG----PERKLLS AqueK257_Aque KEC-FYGKFSEVTDLWAFGVTVWEIYMMSRDYPYSFMTDQEVIDNALKG----FNCVLLE AqueK258_Aque NEC-FYGRFSEKTDVWSFGVLMWEIFTLCKLQPFERMTDQEVIDDAIKG----SERTLPY AqueK259_Aque PEC-FYGRFSEKSDVWGFGVTLWEMFNLCLERPYTNMKDKQIIEGALNG----SL-KVLD AqueK260_Aque TEC-FYGKFSEKSDVWAYGIMVWEVYNMSRDVPYHQLTDAEVLDDALKG----QYRVLPT AqueK261_Aque TEC-FYGKFSEKSDVWAYGIMVWEVYNMSRDVPYHQLTDAEVLDDALKG----QYRVLPT AqueK262_Aque CET-FYGKFSVKSDTWAFGVTLWEVYTLAMCDPYDEMSDEEVIQDAIRG----PNRKLLP * . ..*: :* *. . ::* . *: :.: .:::. CG11573_Dmel MPPNCPREIYDLMC-ECWQRDESSRPSFREIHLYLQRKNLG-FK---------------- DDR2_Mmus QPALCPDSVYKLML-SCWRRETKHRPSFQEIHLLLLQQ---------------------- DDR1_Mmus RPPACPQTLYELML-RCWSREPEQRPPFAQLHRFLADDA--------------------- F11D5.3_Cele RPRMCPSKLYNEQILPCWNYESSRRPSFENVHLHLQSLVH--T----------------- C25F6.4_Cele MPTVFNYEILQLLT-RCFRVDQLERPTFERLVKPF------------------------- DDR2_Hsap QPAICPDSVYKLML-SCWRRDTKNRPSFQEIHLLLLQQ---------------------- DDR1_Hsap RPPACPQGLYELML-RCWSRESEQRPPFSQLHRFLAEDA--------------------- DDR_Spur KPPQCPKDIHNLMK-RCWTSEPGQRPTFDFLHTFLQARNI-GY----------------- AqueK255_Aque KPETCPERVFSVLVKLCWSK---ERKTFAQVHKELVHADQRLYQ---------------- AqueK256_Aque QPVSCSNDAYDIML-RCWVDDPEARASFEELQIH-------------------------- AqueK257_Aque KPETCPERVFSVIVKLCWSK---ERKTFAQVHKELVHADQRLYQ---------------- AqueK258_Aque QPQACPNEVYSVML-DCWIHEPEERASFQQIYDLLSSIHA-------------------- AqueK259_Aque KPECCQTDLYHIMT-SCWRPRAVDRPSFEELHKRLST----------------------- AqueK260_Aque RPTTCPQAVYNIIKKLCWEYQTEERGGFADIYSSLVNVEKTLYSISAVYDVTNPASFDGS AqueK261_Aque RPTTCPQAVYNIIKKLCWEYQTEERGGFADIYSSLVNVEK-------------------- AqueK262_Aque KPEACPREVYDVML-RCWVHDPAMRADFGEIYSRLYMTYT-------------------- * *: * * : CG11573_Dmel ------------------------------------------------------------ DDR2_Mmus ------------------------------------------------------------ DDR1_Mmus ------------------------------------------------------------ F11D5.3_Cele ------------------------------------------------------------ C25F6.4_Cele ------------------------------------------------------------ DDR2_Hsap ------------------------------------------------------------ DDR1_Hsap ------------------------------------------------------------ DDR_Spur ------------------------------------------------------------ AqueK255_Aque ------------------------------------------------------------ AqueK256_Aque ------------------------------------------------------------ AqueK257_Aque ------------------------------------------------------------ AqueK258_Aque ------------------------------------------------------------ AqueK259_Aque ------------------------------------------------------------ AqueK260_Aque NLTTTDPNCPTLVVCFNSTSKLINGDFGPMDSLNGQLGKFFAFSQNNSRVTFQVTTSTRV AqueK261_Aque ------------------------------------------------------------ AqueK262_Aque ------------------------------------------------------------ CG11573_Dmel ------------------------------------------------------------ DDR2_Mmus ------------------------------------------------------------ DDR1_Mmus ------------------------------------------------------------ F11D5.3_Cele ------------------------------------------------------------ C25F6.4_Cele ------------------------------------------------------------ DDR2_Hsap ------------------------------------------------------------ DDR1_Hsap ------------------------------------------------------------ DDR_Spur ------------------------------------------------------------ AqueK255_Aque ------------------------------------------------------------ AqueK256_Aque ------------------------------------------------------------ AqueK257_Aque ------------------------------------------------------------ AqueK258_Aque ------------------------------------------------------------ AqueK259_Aque ------------------------------------------------------------ AqueK260_Aque STVVLYFFNSPADGLGLPQLKVLQSLSLPPVPYFFSNNDELTLTDSQLRTVTLHLNQKLL AqueK261_Aque ------------------------------------------------------------ AqueK262_Aque ------------------------------------------------------------ CG11573_Dmel -----------------------------------PQTHTHMY DDR2_Mmus ----------------------------------------GAE DDR1_Mmus ---------------------------------------LNTV F11D5.3_Cele -------------------------------------SPHIHF C25F6.4_Cele -----------------------------------------QD DDR2_Hsap ----------------------------------------GDE DDR1_Hsap ---------------------------------------LNTV DDR_Spur -------------------------------------EPPVSL AqueK255_Aque -----------------------------------YCDVLHWN AqueK256_Aque ----------------------------------------AYD AqueK257_Aque -----------------------------------YCDVLHWN AqueK258_Aque --------------------------------------YNDFS AqueK259_Aque ----------------------------------------LYH AqueK260_Aque TVQLDFLFPSNSRLNWFLVSEVQLFAGKLLNVWLMYYYLLLNR AqueK261_Aque ---------------------------------------TLYS AqueK262_Aque ---------------------------------------SQAV