CLUSTAL W (1.83) multiple sequence alignment ROCK2_Hsap_ROCK MSRPPPTGKM------------------------PGAPE---------------TAPGDG ROCK1_Hsap_ROCK MSTGD------------------------------------------------------- MRCKb_Hsap_GEK MSAK-------------------------------------------------------- MRCKa_Hsap_GEK MSGE-------------------------------------------------------- CG10522_Dmel_CRIK MPPKMEPIS--------------------------------------------------- rok_Dmel_ROCK MPAGRETVTK--------------------------------------------QRSMDV gek_Dmel_GEK MEYESSEISD-I------------------------------------------T---TG MRCKb_Mmus_GEK MSAK-------------------------------------------------------- MRCKa_Mmus_GEK MSGE-------------------------------------------------------- DMPK2_Mmus_GEK MEQ--------------------------------------------------------- DMPK1_Mmus_GEK MSAE-------------------------------------------------------- CRIK_Mmus_CRIK MLKFKYGVRNPPE-----------------------------------------A-SASE let-502_Cele_ROCK MEQD-------------------------------------------------------- K08B12.5_Cele_GEK MAEPPPD----------------------------------------------------D DMPK2_Hsap_GEK MER--------------------------------------------------------- DMPK1_Hsap_GEK MGGHFWPPEP-Y------------------TVFMWGSPWEA-------------D----- CRIK_Hsap_CRIK MLKFKYGARNPLD-----------------------------------------A-GAAE ROCK1_Mmus_ROCK MSTGD------------------------------------------------------- ROCK2_Mmus_ROCK MSRPPPTGKM------------------------PGAPE---------------TAPGDG MRCK_Spur_GEK MPWPVIAVHR-ARPQARPGPGGSVFAIGQWAWAVLFSPLRPDRPYGKVLQASAGT---GG ROCK_Spur_ROCK MSL--------------------------------------------------------- CRIK_Spur_CRIK ------------------------------------------------------------ CC1G_07309_Ccin_GEK MSLEW------------------------------------------------------- AqueK004_Aque_CRIK MATLSEEETI-------------------------------------------------- AqueK005_Aque_GEK MDKQTP------------------------------------------------------ AqueK006_Aque_ROCK MATEHS------------------------------------------------------ ROCK2_Hsap_ROCK -AGASRQRKL----------------EA----LIRD------------------------ ROCK1_Hsap_ROCK -SFETRFEKM----------------DN----LLRD------------------------ MRCKb_Hsap_GEK ----VRLKKL----------------EQ----LLLDGPW--------------------- MRCKa_Hsap_GEK ----VRLRQL----------------EQ----FILDGPA--------------------- CG10522_Dmel_CRIK ----VRTARL----------------NN----LILGKGAGVCAKPAGSASGSGIPASTRR rok_Dmel_ROCK -ERRRRANTL----------------ER----EMRD------------------------ gek_Dmel_GEK -SCKKRLTFL----------------KC----ILSDTTSDQ------------------- MRCKb_Mmus_GEK ----VRLKKL----------------EQ----LLLDGPW--------------------- MRCKa_Mmus_GEK ----VRLRQL----------------EQ----FILDGPA--------------------- DMPK2_Mmus_GEK -----RLRAL----------------EQ----LVRGE----------------------- DMPK1_Mmus_GEK ----VRLRQL----------------QQ----LVL-D----------------------- CRIK_Mmus_CRIK -PIASRASRL----------------NL----FFQGKPPL-------------------- let-502_Cele_ROCK --------EL----------------RD----QLVD------------------------ K08B12.5_Cele_GEK -SAPVRLKTL----------------EN----IYMDGPS--------------------- DMPK2_Hsap_GEK -----RLRAL----------------EQ----LARGE----------------------- DMPK1_Hsap_GEK -SPRVKLRGR----------------EK----GRQTE----------------------- CRIK_Hsap_CRIK -PIASRASRL----------------NL----FFQGKPPF-------------------- ROCK1_Mmus_ROCK -SFETRFEKI----------------DN----LLRD------------------------ ROCK2_Mmus_ROCK -AGAGRQRKL----------------EA----LIRD------------------------ MRCK_Spur_GEK DISETQVKKFLGGVRSFFCEAVSYALSR----LPLDEPVLQH----------ATFVDWHQ ROCK_Spur_ROCK ---TQRYQTL----------------EN----RIKD------------------------ CRIK_Spur_CRIK ------------------------------------------------------------ CC1G_07309_Ccin_GEK -----VYR---------------------------F------------------------ AqueK004_Aque_CRIK --IHERFLQL----------------KSAALTLLEEGGGR-------------------- AqueK005_Aque_GEK ---DSKARRL----------------EI----GIRERRP--------------------- AqueK006_Aque_ROCK -SLKARHKTL----------------LG----SLTD------------------------ ROCK2_Hsap_ROCK ---------------------------------PRSPINVESLLDGLNSLVLDLDF---- ROCK1_Hsap_ROCK ---------------------------------PKSEVNSDCLLDGLDALVYDLDF---- MRCKb_Hsap_GEK -------------------------------R-NESALSVETLLDVLVCLYTECSH---- MRCKa_Hsap_GEK -------------------------------QTNGQCFSVETLLDILICLYDECNN---- CG10522_Dmel_CRIK SIVP----------------------VSTTSAAVAEAICREGLLDAFCLLYNECDK---- rok_Dmel_ROCK ---------------------------------PTSICNVDCLLDTVSALVSDCDH---- gek_Dmel_GEK KW-----------------------AAEFGEDTEGHQFSLDYLLDTFIVLYDECSN---- MRCKb_Mmus_GEK -------------------------------R-NDSALSVETLLDVLVCLYTECSH---- MRCKa_Mmus_GEK -------------------------------QTNGQCFSVETLLDILICLYDECNN---- DMPK2_Mmus_GEK ---------------------------------AGGSPGLDGLLDLLLGVHQELSS---- DMPK1_Mmus_GEK ---------------------------------P-GFLGLEPLLDLLLGVHQELGA---- CRIK_Mmus_CRIK -----------------------------MTQQQMSALSREGMLDALFALFEECSQ---- let-502_Cele_ROCK ---------------------------------PKSPINIESLLDTITALVNDCKI---- K08B12.5_Cele_GEK -------------------------------K-KPEALSFETLIDSLICLYDECCN---- DMPK2_Hsap_GEK ---------------------------------AGGCPGLDGLLDLLLALHHELSS---- DMPK1_Hsap_GEK ---------------------------------G-GAFP--------------LVS---- CRIK_Hsap_CRIK -----------------------------MTQQQMSPLSREGILDALFVLFEECSQ---- ROCK1_Mmus_ROCK ---------------------------------PKSEVNSDCLLDGLDALVYDLDF---- ROCK2_Mmus_ROCK ---------------------------------PRSPINVESLLDGLNSLVLDLDF---- MRCK_Spur_GEK KMEASIDDDVLFFIDSNADAERVFSSIGLNKTETRNALHLDGTLSSIMTIKMAASEPCYR ROCK_Spur_ROCK ---------------------------------PKCLINYEALLDSICALTRDCGI---- CRIK_Spur_CRIK -----------------------------------SHLSRDGLVDALLALYGECSQ---- CC1G_07309_Ccin_GEK ---------------------------------TISCVSI------------QIDL---- AqueK004_Aque_CRIK -----------------------------LSDQRLVRLGYDCLLDSLESVYKECSS---- AqueK005_Aque_GEK -------------------------------EDRSNNFCVESLIDALVVLYDECCS---- AqueK006_Aque_ROCK ---------------------------------NKGLLHVEGLLDAVVAVYSDCNY---- ROCK2_Hsap_ROCK --------------P-ALR-K-NKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGA ROCK1_Hsap_ROCK --------------P-ALR-K-NKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGA MRCKb_Hsap_GEK --------------S-ALR-R-DKYVAEFLEWAKPFTQLVKEMQLHREDFEIIKVIGRGA MRCKa_Hsap_GEK --------------S-PLR-R-EKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGA CG10522_Dmel_CRIK --------------D-TLKKR-DRNIAEFVNKFRPIIEETRKLRVNADDFLIKTLIGQGY rok_Dmel_ROCK --------------E-SLR-R-LKNIEQYAAKYKPLAMQINQLRMNVEDFHFIKLIGAGA gek_Dmel_GEK --------------S-SLR-R-EKGVSDFLKLSKPFVHIVRKLRLSRDDFDILKIIGRGA MRCKb_Mmus_GEK --------------S-ALR-R-DKYVAEFLEWAKPFTQLVKDMQLHREDFEIIKVIGRGA MRCKa_Mmus_GEK --------------S-PLR-R-EKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGA DMPK2_Mmus_GEK --------------A-PLR-R-ERNVAQFLSWASPFVTKVKELRLQRDDFEILKVIGRGA DMPK1_Mmus_GEK --------------S-HLA-Q-DKYVADFLQWVEPIAARLKEVRLQRDDFEILKVIGRGA CRIK_Mmus_CRIK --------------P-ALM-K-MKHVSSFVQKYSDTIAELRELQPSARDFEVRSLVGCGH let-502_Cele_ROCK --------------P-VLM-R-MKSVDNFISRYERVVESLAALRMKAADFRQLKVIGRGA K08B12.5_Cele_GEK --------------S-TLR-K-EKCIAEFVESVKTVISKAKKLRLSRDDFEVLKVIGKGA DMPK2_Hsap_GEK --------------G-PLR-R-ERSVAQFLSWASPFVSKVKELRLQRDDFEILKVIGRGA DMPK1_Hsap_GEK --------------S-ALS-GDPRFFSPTTPPAEPIVVRLKEVRLQRDDFEILKVIGRGA CRIK_Hsap_CRIK --------------P-ALM-K-IKHVSNFVRKYSDTIAELQELQPSAKDFEVRSLVGCGH ROCK1_Mmus_ROCK --------------P-ALR-K-NKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGA ROCK2_Mmus_ROCK --------------P-ALR-K-NKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGA MRCK_Spur_GEK FEPPAEGLLLALLMQ-TLR-Y-TVYMFMYEEGAKLPVKKVKDLRLHKEDFETLKIIGRGA ROCK_Spur_ROCK --------------P-ALR-K-SKNVENFLSRYEQKAGDITTHRLSSHDFQMIKVIGRGA CRIK_Spur_CRIK --------------D-QLK-R-NKHAAQFVNKCKHIGQQVKNLQISINDFEVKDVIGRGH CC1G_07309_Ccin_GEK --------------S-----------------TTAKTAEIDSLRFQDKDLQVVGTLEYGQ AqueK004_Aque_CRIK --------------SASLS-K-DKYVSRFLKKYKPVMEDFDKLRLKETDFITKGIIGQGH AqueK005_Aque_GEK --------------S-NQK-R-ERTVVEFVERVKPVIDRVKECRLTADDFEVLEVIGRGA AqueK006_Aque_ROCK --------------P-TLH-R-NKNLDTFRRRYEGVVPVISNNRLSSHDFQLIKVIGRGA : * : * ROCK2_Hsap_ROCK FGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA---NSPWVVQLFYAF ROCK1_Hsap_ROCK FGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA---NSPWVVQLFYAF MRCKb_Hsap_GEK FGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNG---DCQWITALHYAF MRCKa_Hsap_GEK FGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNG---DNKWITTLHYAF CG10522_Dmel_CRIK FGNVHLVVERQTNDIYAMKKIKKSVV----TTSQVKEERDIMSIR---NSEWLINLQYAF rok_Dmel_ROCK FGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHA---NSEWIVQLHFAF gek_Dmel_GEK FGEVCVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFG---DRQWITNLHYAF MRCKb_Mmus_GEK FGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNG---DCQWITALHYAF MRCKa_Mmus_GEK FGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNG---DSKWITTLHYAF DMPK2_Mmus_GEK FGEVAVVRQRGSGQIFAMKMLHKWEMLKRAETACFREERDVLVKG---DSRWVTALHYAF DMPK1_Mmus_GEK FSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVKG---DRRWITQLHFAF CRIK_Mmus_CRIK FAEVQVVREKATGDVYAMKIMKKKALLAQEQVSFFEEERNILSRS---TSPWIPQLQYAF let-502_Cele_ROCK FGEVHLVRHTRTNTVYAMKMLNKDDMIKRADSAFFWEERDIMAHA---NSEWIVRLQYAF K08B12.5_Cele_GEK FGEVAVVRMRGVGEIYAMKILNKWEMVKRAETACFREERDVLVYG---DRRWITNLHYAF DMPK2_Hsap_GEK FGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREERDVLVKG---DSRWVTTLHYAF DMPK1_Hsap_GEK FSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNG---DRRWITQLHFAF CRIK_Hsap_CRIK FAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRS---TSPWIPQLQYAF ROCK1_Mmus_ROCK FGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA---NSPWVVQLFYAF ROCK2_Mmus_ROCK FGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFA---NSPWVVQLFCAF MRCK_Spur_GEK FGEVAVVKLKNSDDVFAMKLLNKWEMLKRAETACFVEERDVLVHG---DSRWITNLHYAF ROCK_Spur_ROCK FGEVKVVRERTSKKVYAMKCLSKFEMIKRSDSAFYWEERDIMAHA---NSEWIVQLHYAF CRIK_Spur_CRIK FGQVQVVREKVTNDVYAMKVLHKAETLAKENVAFFEEEKDIMARA---SSPWLTKLQYAF CC1G_07309_Ccin_GEK FGVIEVVTCKLNNRVYVRKSIEKKFAMRTREQCSPQTERNILVAASLTESPWAPHLLAAY AqueK004_Aque_CRIK FGEVRVVQEKTTSQIYAMKIMKKTHILQQADATFFIEERDIMALG---NSQWLTKLHYAF AqueK005_Aque_GEK FGEVKVVRLKSTNKVYALKVLNKAEMLQRQTTACFKEERDVLVFG---NRDWITKLHYAF AqueK006_Aque_ROCK FGEVHLVRMKETKKIFAMKILSKFEMIRRSDTAFFWEERDIMAHT---TSEWIVQLHYAF *. : :* ::. * : * *:.:: * * *: ROCK2_Hsap_ROCK QDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFYTAEVVLALDAIHSMGLIHRDVKP ROCK1_Hsap_ROCK QDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEVVLALDAIHSMGFIHRDVKP MRCKb_Hsap_GEK QDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKP MRCKa_Hsap_GEK QDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQLHYVHRDIKP CG10522_Dmel_CRIK QDNDNLYLVMEYMPGGDLLSLMSRHG-PFDEDLARFYLAELTVALHTLHEMGYVHRDIKP rok_Dmel_ROCK QDAKYLYMVMDFMPGGDIVSLMGDYD--IPEKWAIFYTMEVVLALDTIHNMGFVHRDVKP gek_Dmel_GEK QDNINLYLVMDYYCGGDLLTLLSKFEDKLPEDMAKFYITEMILAINSIHQIRYVHRDIKP MRCKb_Mmus_GEK QDENYLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKP MRCKa_Mmus_GEK QDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSVHQLHYVHRDIKP DMPK2_Mmus_GEK QDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKP DMPK1_Mmus_GEK QDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKP CRIK_Mmus_CRIK QDKNNLYLVMEYQPGGDLLSLLNRYEDQLDESMIQFYLAELILAVHSVHQMGYVHRDIKP let-502_Cele_ROCK QDPRHLYMVMEYMPGGDLVNLMTSYE--VSEKWTRFYTAEIVEALAALHSMGYIHRDVKP K08B12.5_Cele_GEK QDEKNLYFVMDYYIGGDMLTLLSKFVDHIPESMAKFYIAEMVLAIDSLHRLGYVHRDVKP DMPK2_Hsap_GEK QDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKP DMPK1_Hsap_GEK QDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKP CRIK_Hsap_CRIK QDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDIKP ROCK1_Mmus_ROCK QDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWARFYTAEVVLALDAIHSMGFIHRDVKP ROCK2_Mmus_ROCK QDDRYLYMVMEYMPGGDLVNLMSNYD--VPEKWAKFYTAEVVLALDAIHSMGLIHRDVKP MRCK_Spur_GEK QDDDFLYLVMDYYSGGDLLTLISKFDDRLPEDMARFYVAEMVLAIDSVHMLRYVHRDIKP ROCK_Spur_ROCK QDEKYLYMVMDYMPGGDLVNLMSNYE--IPEKWARFYTAEVVLALDAIHSMGFIHRDVKP CRIK_Spur_CRIK QDDDNLYLMMEFHPGGDLLSLLARFDDVFEENMARFYLAELVAAIHSLHTMGYVHRDIKP CC1G_07309_Ccin_GEK QMPTHLHLVMDYAEGGNLWDVLESSTGKISESDLKWWVPQAVSAIHWCHTQGFAHRDIKP AqueK004_Aque_CRIK QDEKCLYLVMDYHPGGDLFTVMERKEMGMTEGEACFYTAEIICALHDLHQLGFVHRDVKP AqueK005_Aque_GEK QDKNNLYFVMDYYLGGDVLTLLSKFEDRLTEDMVKFYASEMILAIHSIHDLGYVHRDIKP AqueK006_Aque_ROCK QDSSNLYMVMDYMPGGNIVSLMERYE--IPEEWAQFYIAELVLALEAVHSMGYVHRDVKP * *:::*:: **:: :: . :: : *: * ***:** ROCK2_Hsap_ROCK DNMLLDKHGHLKLADFGTCMKMDETGMV--------HCDTAVGTPDYISPEVLKSQ-G-- ROCK1_Hsap_ROCK DNMLLDKSGHLKLADFGTCMKMNKEGMV--------RCDTAVGTPDYISPEVLKSQ-G-- MRCKb_Hsap_GEK DNVLLDVNGHIRLADFGSCLKMNDDGTV--------QSSVAVGTPDYISPEILQAMED-- MRCKa_Hsap_GEK DNILMDMNGHIRLADFGSCLKLMEDGTV--------QSSVAVGTPDYISPEILQAMED-- CG10522_Dmel_CRIK ENILIDRFGHIKLADFGNAAALDRDGHV--------LSLSPVGTPDYIAPELLQTISTYK rok_Dmel_ROCK DNMLLDSYGHLKLADFGTCMRMGANGQV--------VSSNAVGTPDYISPEVLQSQ-G-- gek_Dmel_GEK DNVLLDKRGHVRLADFGSCLRLDKDGTV--------QSNVAVGTPDYISPEILRAMED-- MRCKb_Mmus_GEK DNVLLDVNGHIRLADFGSCLKMNDDGTV--------QSSVAVGTPDYISPEILQAMED-- MRCKa_Mmus_GEK DNILMDMNGHIRLADFGSCLKLMEDGTV--------QSSVAVGTPDYISPEILQAMED-- DMPK2_Mmus_GEK DNILLDMNGHIRLADFGSCLRLNNNGMV--------DSSVAVGTPDYISPEILQAMEE-- DMPK1_Mmus_GEK DNILLDRCGHIRLADFGSCLKLQPDGMV--------RSLVAVGTPDYLSPEILQAVGGG- CRIK_Mmus_CRIK ENILIDRTGHIKLVDFGSAAKMNSN-KV--------DAKLPIGTPDYMAPEVLTVMNE-- let-502_Cele_ROCK DNMLISISGHIKLADFGTCVKMNANGVV--------RCSTAVGTPDYISPEVLRNQ-G-- K08B12.5_Cele_GEK DNVLLDMQGHIRLADFGSCLRILADGSV--------ASNVAVGTPDYISPEILRAMED-- DMPK2_Hsap_GEK DNVLLDVNGHIRLADFGSCLRLNTNGMV--------DSSVAVGTPDYISPEILQAMEE-- DMPK1_Hsap_GEK DNILLDRCGHIRLADFGSCLKLRADGTV--------RSLVAVGTPDYLSPEILQAVGGG- CRIK_Hsap_CRIK ENILVDRTGHIKLVDFGSAAKMNSNKMV--------NAKLPIGTPDYMAPEVLTVMNG-- ROCK1_Mmus_ROCK DNMLLDKSGHLKLADFGTCMKMNKEGMV--------RCDTAVGTPDYISPEVLKSQ-G-- ROCK2_Mmus_ROCK DNMLLDKHGHLKLADFGTCMKMDETGMV--------HCDTAVGTPDYISPEVLKSQ-G-- MRCK_Spur_GEK DNVLLDKHGHIRLADFGSCLRMLPDNTV--------MSNVAVGTPDYISPEILRAMED-- ROCK_Spur_ROCK DNMLLDSSGHLKLADFGTCMRMERDGMV--------RSDTAVGTPDYISPEVLKSQ-A-- CRIK_Spur_CRIK DNVLLDRTGHIKLADFGSAAKLGDKNTV--------SSKMPVGTPDYVAPEVLQSLN--- CC1G_07309_Ccin_GEK HNFVLTKDSRVQLIDFGSAAPLLPPGPDGSQKLARKHCLVPCGTCDYISPEILEAHEQAL AqueK004_Aque_CRIK DNVLITRSGHIKLVDFGSASRLDENGKV-------VDYTLPVGTPEYISPEVLTSLD--- AqueK005_Aque_GEK DNVLIGKDGHIRLADFGSCLKMDSNRKV--------NSTTAVGTPDYISPEILQAMED-- AqueK006_Aque_ROCK ENMLLDGRGHLKLADFGTCMKVDKNGKV--------RCETAVGTPDYISPEVLKSQ-G-- .*.:: .:::* ***.. : . ** :*::**:* ROCK2_Hsap_ROCK ----------------GDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDH- ROCK1_Hsap_ROCK ----------------GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNH- MRCKb_Hsap_GEK ----------------GMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNH- MRCKa_Hsap_GEK ----------------GKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNH- CG10522_Dmel_CRIK ---------------LSKSMHDVSCDYWSMGIIGYELICETTPFHEDNVHETYSKILSHC rok_Dmel_ROCK ----------------VDNEYGRECDWWSVGIFLYEMLFGETPFYADSLVGTYGKIMDH- gek_Dmel_GEK ----------------GKGRYGTECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNH- MRCKb_Mmus_GEK ----------------GMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNH- MRCKa_Mmus_GEK ----------------GKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNH- DMPK2_Mmus_GEK ----------------GKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNH- DMPK1_Mmus_GEK ---------------PGAGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYAKIVHY- CRIK_Mmus_CRIK ---------------DRRGTYGLDCDWWSVGVVAYEMVYGKTPFTEGTSARTFNNIMNF- let-502_Cele_ROCK ----------------QDAEFGKEVDWWSVGVFIYEMLVGETPFYAEALVSTYTNIMNH- K08B12.5_Cele_GEK ----------------GRGRYGKECDWWSLGICMYEMLYGTTPFYSERLVDTYGKIMSH- DMPK2_Hsap_GEK ----------------GKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNH- DMPK1_Hsap_GEK ---------------PGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHY- CRIK_Hsap_CRIK ---------------DGKGTYGLDCDWWSVGVIAYEMIYGRSPFAEGTSARTFNNIMNF- ROCK1_Mmus_ROCK ----------------GDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNH- ROCK2_Mmus_ROCK ----------------GDGYYGRECDWWSVGVFLFEMLVGDTPFYADSLVGTYSKIMDH- MRCK_Spur_GEK ----------------GKGRYGPECDWWSLGVCMYEMLFGETPFYAESLVETYGKIMNH- ROCK_Spur_ROCK ----------------GNGQYGRECDWWSVGVFIYEMLVGDTPFYADSLVGTYSKIMDH- CRIK_Spur_CRIK ---------------GSLASYGTECDWWSLGIVAYEMMVGKTPFSDDSMVITYSNIMDF- CC1G_07309_Ccin_GEK VALEMDDEDENPLVIEDPEGYGVETDWWSLGAMLYEMAYGVAPFFANEIRHTYQRILNH- AqueK004_Aque_CRIK ----------------KKLTYGVSCDWWSVGIIMYELLFEVTPFEGSTTAETYANIMSY- AqueK005_Aque_GEK ----------------GRGVYGPECDWWSLGICIYEMLFGETPFYAESLLQTYSKIMQH- AqueK006_Aque_ROCK ----------------GDGYYGKECDWWSVGVVMFEMLCGDLPFYSDSLIGTYSNIMNH- .. . *:*::* :*: ** *: .*: . ROCK2_Hsap_ROCK -----KNSLCFPEDA----EISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWH ROCK1_Hsap_ROCK -----KNSLTFPDDN----DISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWA MRCKb_Hsap_GEK -----EERFQFPSHVT---DVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLN-- MRCKa_Hsap_GEK -----KERFQFPAQVT---DVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGID-- CG10522_Dmel_CRIK EESHLKELISFPADL----KVSVNYRNLIESLVTNPSKRLSY---ERIKNHPFFSEIP-- rok_Dmel_ROCK -----KNSLSFPPEV----EISEQAKALIRAFLTDRTQRLGRYGIEDIKAHPFFRNDTWS gek_Dmel_GEK -----QNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGIQDFMDHPWFVGID-- MRCKb_Mmus_GEK -----EERFQFPSHVT---DVSEEAKDLIQRLICSRERRLGQNGIEDFKKHAFFEGLN-- MRCKa_Mmus_GEK -----KERFQFPAQVT---DVSENAKDLIRRLICSREHRLGQNGIEDFKKHPFFSGID-- DMPK2_Mmus_GEK -----EDHLQFPADVT---DVPASAQDLIRQLLCRQEERLGRGGLDDFRKHPFFEGVD-- DMPK1_Mmus_GEK -----REHLSLPLADT---VVPEEAQDLIRGLLCPAEIRLGRGGAGDFQKHPFFFGLD-- CRIK_Mmus_CRIK -----QRFLKFPDDP----KVSSELLDLLQSLLCVQKERLKF---EGLCCHPFFARTD-- let-502_Cele_ROCK -----KTSLKFPDEP----LISTQAKDIIKKFLSAAPDRLGRNSVDDIRNHKFFVNDEWT K08B12.5_Cele_GEK -----QDMLDFPDDEI-DWVVSEEAKDLIRQLICSSDVRFGRNGLSDFQLHPFFEGID-- DMPK2_Hsap_GEK -----EDHLQFPPDVP---DVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVD-- DMPK1_Hsap_GEK -----KEHLSLPLVDE---GVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLD-- CRIK_Hsap_CRIK -----QRFLKFPDDP----KVSSDFLDLIQSLLCGQKERLKF---EGLCCHPFFSKID-- ROCK1_Mmus_ROCK -----KNSLTFPDDN----DISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWA ROCK2_Mmus_ROCK -----KNSLCFPEDT----EISKHAKNLICAFLTDREVRLGRNGVEEIKQHPFFKNDQWN MRCK_Spur_GEK -----KNQFDFPPETEEEVAISEDAKDLILSLICSAEARLGRNGLQDFKDHPFFNDID-- ROCK_Spur_ROCK -----RNSLEFPDDI----SISGPAKDLICKFLTDRDTRLGKNGIDEIKLHRFFKNDMWT CRIK_Spur_CRIK -----QRKLSFPTSS----PLTPRATSLIKQLLCDRSARIGY---EQLGYHEFFTGLE-- CC1G_07309_Ccin_GEK -----EKCLRFED------GVSFELQDLLARLLTRAEKRLGRRNIMEITDHPFFRGTD-- AqueK004_Aque_CRIK -----QTSLQIPEE------LSPEARSLIESLLVKPEKRLEY---PDIVKHPFFKQVD-- AqueK005_Aque_GEK -----KTLFSFPSDED-SIVVSKDAKNLIKNLICDAEERLGQSGIDDFKKHPFFEGID-- AqueK006_Aque_ROCK -----KNTLQFTD-V----QLSANAKNIIVHFLEDASNRLGLNGVEEVKAHPFFVTDQWN . : : :. :: :: *: . * :* ROCK2_Hsap_ROCK WDNIRETAAPV---VPELS----SDIDS-----SNFDDI--EDDK--GD----------- ROCK1_Hsap_ROCK WETLRDTVAPV---VPDLS----SDIDT-----SNFDDL--EEDK--GE----------- MRCKb_Hsap_GEK WENIRNLEAPY---IPDVS----SPSDT-----SNFDVD--DDVL--RN----------- MRCKa_Hsap_GEK WDNIRNCEAPY---IPEVS----SPTDT-----SNFDVD--DDCL--KN----------- CG10522_Dmel_CRIK WGSIRSQVPPI---IPTVR----SDDDT-----SNFEDG--IRHKT-RREQGV------- rok_Dmel_ROCK FDNIRESVPPV---VPELS----SDDDT-----RNFEDI--ERDE--KP----------- gek_Dmel_GEK WKNIRQGPAPY---VPEVS----SPTDT-----SNFDVD--DNDV--RL----------- MRCKb_Mmus_GEK WENIRNLEAPY---IPDVS----SPSDT-----SNFDVD--DDML--RN----------- MRCKa_Mmus_GEK WDNIRNCEAPY---IPEVS----SPTDT-----SNFDVD--DDCL--KN----------- DMPK2_Mmus_GEK WERLATSTAPY---IPELR----GPMDT-----SNFDVD--DDTL--NR----------- DMPK1_Mmus_GEK WEGLRDSVPPF---TPDFE----GATDT-----CNFDVV--EDRL--TAMV-S------- CRIK_Mmus_CRIK WNNIRNSPPPF---VPTLK----SDDDT-----SNFDEP--EKN--SWV----------- let-502_Cele_ROCK FATLREASPPV---IPSLK----SDDDT-----THFEEI--ETRDR-DN----------- K08B12.5_Cele_GEK WNTIRDSNPPY---VPEVS----SPEDT-----SNFDVDVCEDDF--TP----------- DMPK2_Hsap_GEK WERLASSTAPY---IPELR----GPMDT-----SNFDVD--DDTL--NH----------- DMPK1_Hsap_GEK WDGLRDSVPPF---TPDFE----GATDT-----CNFDLV--EDGL--TAMV-S------- CRIK_Hsap_CRIK WNNIRNSPPPF---VPTLK----SDDDT-----SNFDEP--EKN--SWV----------- ROCK1_Mmus_ROCK WETLRDTVAPV---VPDLS----SDIDT-----SNFDDL--EEDK--GD----------- ROCK2_Mmus_ROCK WDNIRETAAPV---VPELS----SDIDS-----SNFDDI--EDDK--GD----------- MRCK_Spur_GEK WQNIRNMTPPY---VPDVK----SATDT-----SNFDVD--EADL--RN----------- ROCK_Spur_ROCK YDNIRNTVPPV---VPELI----SDVDT-----SNFDEI--EPED--HP----------- CRIK_Spur_CRIK WATLRDGKPPF---VPTVS----SVDDV-----SNFDEF--DPIEPMKH----------- CC1G_07309_Ccin_GEK WTSLSSQSAPPDLHLPQFTYSIPQPTEAANHVPSPMDVD--DKSE--SYSQ-GFAFSAFF AqueK004_Aque_CRIK WNNIASMTPPF---VPVIK----GPTDT-----SNFDSF--DPVDD-PAD---------- AqueK005_Aque_GEK WDNIRSQTPPY---IPEFT----SDTDT-----RNFEPY--EPDD--PG----------- AqueK006_Aque_ROCK WENIRSTVAYV---VPELK----SEIDT-----AYFDDI--EDTS--TQ----------- : : . * . : :: ROCK2_Hsap_ROCK ----------------VETFPI--PKAFVGNQLPFIGFTYYRENLLL-SDSPS-CRETDS ROCK1_Hsap_ROCK ----------------EETFPI--PKAFVGNQLPFVGFTYYSNRRYL-SSANP-NDNRTS MRCKb_Hsap_GEK ----------------TEILPPGSHTGFSGLHLPFIGFTFTTESC--FSDRGS-LKSIMQ MRCKa_Hsap_GEK ----------------SETMPPPTHTAFSGHHLPFVGFTYTSSCV--LSDRSC-LRVTAG CG10522_Dmel_CRIK --------------AKKSLTTNMKSNDFSGKDLPFIGYSFVHMEKSAISATT-DE----- rok_Dmel_ROCK ----------------EEVFPV--PKGFDGNHLPFIGFTYTGDYQLL-SSDTVDAESKEA gek_Dmel_GEK ----------------TDSIPPSANPAFSGFHLPFIGFTFSLTSSSTLDSKKN-QSSGFG MRCKb_Mmus_GEK ----------------IEILPPGSHTGFSGLHLPFIGFTFTTESC--FSDRGS-LKSMTQ MRCKa_Mmus_GEK ----------------SETMPPPTHTAFSGHHLPFVGFTYTSSCV--LSDRSC-LRVTAG DMPK2_Mmus_GEK ----------------PETLPPSSHGAFSGHHLPFVGFTYTSGSP--FDVQSS-EL---- DMPK1_Mmus_GEK --------------GGGETLSDMQEDMPLGVRLPFVGYSYCCMAF--RDNQVP-DP---- CRIK_Mmus_CRIK ----------------SSSVCQLSPSGFSGEELPFVGFSYSKALGYL-GRSES-VVSSLD let-502_Cele_ROCK ----------------AGDFQL--PKTFNGNQLPFIGFTYSNEYSPV-KN--L-LKGHGA K08B12.5_Cele_GEK ----------------CETQPPRVLAAFTGNHLPFVGFSYTHGSL--LSDARS-LTDEIR DMPK2_Hsap_GEK ----------------PGTLPPPSHGAFSGHHLPFVGFTYTSGSH--SPESSS-EA---- DMPK1_Hsap_GEK --------------GGGETLSDIREGAPLGVHLPFVGYSYSCMAL--RDSEVP-GP---- CRIK_Hsap_CRIK ----------------SSSPCQLSPSGFSGEELPFVGFSYSKALGIL-GRSES-VVSGLD ROCK1_Mmus_ROCK ----------------EETFPI--PKAFVGNQLPFVGFTYYSNRRYL-PSANA-SENRSS ROCK2_Mmus_ROCK ----------------VETFPI--PKAFVGNQLPFIGFTYFRENLLL-SDSPP-CRENDA MRCK_Spur_GEK ----------------SEVLPPSSHAAFTGNHLPFLGYTFTRNSN--LSDLGK-LADVKE ROCK_Spur_ROCK ----------------EESFQS--PKTFAGNNLPFIGFTYNKSNKLF-TSVEGGVKEADG CRIK_Spur_CRIK ----------------NASILMRCKGGFSGHDLPFVGFTYSKTSSIL-TLRSM-MNTTLS CC1G_07309_Ccin_GEK QSSHGSVSHNASFLRHSITPRPPRPSPRDDPSSAFIGFSWGPLIDAF-PDQPLG-VSQNS AqueK004_Aque_CRIK -----------------ANMTYKSSRSFTGRE-PAIHWVQLHQ--L-------------- AqueK005_Aque_GEK ----------------HDPTPPN-LTA-LTLHLPFVGFTFTSGSA--LSDRPP-LPSLVT AqueK006_Aque_ROCK ----------------PQAFSQ--PMEFQGNHLPFVGFTFVKDSNIL-EGEREQVSSVEA . : : ROCK2_Hsap_ROCK IQS---------------------RKNE---------E------------SQEIQKKLYT ROCK1_Hsap_ROCK SNA---------------------DK-S---------L------------QESLQKTIYK MRCKb_Hsap_GEK SNTL--------------------TKD------------------------EDVQRD--- MRCKa_Hsap_GEK PTSL--------------------DLD------------------------VNVQRT--- CG10522_Dmel_CRIK ---------------------------K---------L------------QEKLKELLQK rok_Dmel_ROCK NVA---------------------NSGA---------ASNNHGHGHNHRHRPSNSNELKR gek_Dmel_GEK DDTL--------------------DTI------------------------SSPQLA--- MRCKb_Mmus_GEK SNTL--------------------TKD------------------------EDVQRD--- MRCKa_Mmus_GEK PTSL--------------------DLD------------------------VSVQRT--- DMPK2_Mmus_GEK ------------------------------------------------------------ DMPK1_Mmus_GEK ------------------------------------------------------------ CRIK_Mmus_CRIK SPAK--------------------VSSMEKKLLIKSKE------------LQDSQDKCHK let-502_Cele_ROCK GSK---------------------QN-G---------I------------EQHK--PQTV K08B12.5_Cele_GEK AIAQ--------------------R----------------------------CQ----- DMPK2_Hsap_GEK ------------------------------------------------------------ DMPK1_Hsap_GEK ------------------------------------------------------------ CRIK_Hsap_CRIK SPAK--------------------TSSMEKKLLIKSKE------------LQDSQDKCHK ROCK1_Mmus_ROCK SNV---------------------DK-S---------L------------QESLQKTIYK ROCK2_Mmus_ROCK IQT---------------------RKSE---------E------------SQEIQKKLYA MRCK_Spur_GEK VISS------------------------------------------------GIKEG--- ROCK_Spur_ROCK HVSAPNVGGRGGVKEADGHVSAPNVGGR---------E------------YEEMKRKTHS CRIK_Spur_CRIK APME--------------------MSSM---------P------------DQKLQDRCRR CC1G_07309_Ccin_GEK D----------------------------------------------------------- AqueK004_Aque_CRIK ------------------------------------------------------------ AqueK005_Aque_GEK R-----------------------EQE------------------------TGIITQ--- AqueK006_Aque_ROCK TPI---------------------KPS-------------------------------KE ROCK2_Hsap_ROCK L---EEHLSNEMQAKEELEQKCKSVNTRLEKTAKEL-----------EEEITLRKSVES- ROCK1_Hsap_ROCK L---EEQLHNEMQLKDEMEQKCRTSNIKLDKIMKEL-----------DEEGNQRRNLES- MRCKb_Hsap_GEK L---EHS--------------------------------------------LQMEAYER- MRCKa_Hsap_GEK L---DNN--------------------------------------------LATEAYER- CG10522_Dmel_CRIK LKTRENEISMLKQDLLRAQQSLRKTDNKSQVVADA---------------KMEIKK---- rok_Dmel_ROCK L---EALLERERGRSEALEQQDAGLRQQIELITK------------------REAELQR- gek_Dmel_GEK I---L------------------------------------------------------- MRCKb_Mmus_GEK L---ENS--------------------------------------------LQIEAYER- MRCKa_Mmus_GEK L---DNN--------------------------------------------LATEAYER- DMPK2_Mmus_GEK -----------------------------------------------------MAAPEG- DMPK1_Mmus_GEK ------------------------------------------------------------ CRIK_Mmus_CRIK M---EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRS---- let-502_Cele_ROCK V---EQPLTNGH-ASGVPEEKYEAVKMELDSKNREF-----------ELLKDSIARNEI- K08B12.5_Cele_GEK G---DAE--------------------------------------------LMEKSVDG- DMPK2_Hsap_GEK -----------------------------------------------------WAALER- DMPK1_Hsap_GEK ------------------------------------------------------------ CRIK_Hsap_CRIK M---EQEMTRLHRRVSEVEAVLSQKEVELKASETQRSLLEQDLATYITECSSLKRS---- ROCK1_Mmus_ROCK L---EEQLHNEMQLKDEMEQKCRTSNLKLDKIMKEL-----------DEEGNQRRNLES- ROCK2_Mmus_ROCK L---EEHLSSEVQAKEELEQKCKSINTRLEKTAKEL-----------EEEITLRKSVES- MRCK_Spur_GEK V---VDS--------------------------------------------AQVESLER- ROCK_Spur_ROCK L---EKQIEAEMRRNKDLDQKNKHIASKFDRIKQDL-----------ELENNDKLHLQN- CRIK_Spur_CRIK L---ESQHSSLTRHNNELSKSLKEKTEALKTIQPEKNAVERKL--------ALRRT---- CC1G_07309_Ccin_GEK ------------------------------------------------------------ AqueK004_Aque_CRIK ----------------KCREELRAANEEKRSIRQES-----------DIYRKQMMDLHRR AqueK005_Aque_GEK L----------------------------------------------------------- AqueK006_Aque_ROCK I---EEQLTLLTKQKEDLETHIKKTEEKLQRMEKEN-----------REVQASLNQVTQ- ROCK2_Hsap_ROCK ----------------------------------------------ALRQLEREKALLQH ROCK1_Hsap_ROCK ----------------------------------------------TVSQIEKEKMLLQH MRCKb_Hsap_GEK ----------------------------------------------RIRRLEQEKLELSR MRCKa_Hsap_GEK ----------------------------------------------RIKRLEQEKLELSR CG10522_Dmel_CRIK LQQIIKEKTMELTTCKTQIKTLQ---SSAK-ID-EEMWSKKEATITDLLRLNRQK-YEEA rok_Dmel_ROCK ----------------------------------------------IASEYEKDLALRQH gek_Dmel_GEK ------------------------------------------------------------ MRCKb_Mmus_GEK ----------------------------------------------RIRRLEQEKLELSR MRCKa_Mmus_GEK ----------------------------------------------RIKRLEQEKLELTR DMPK2_Mmus_GEK ----------------------------------------------TPHCVEQVKVELSH DMPK1_Mmus_GEK ----------------------------------------------TPMELEALQ----- CRIK_Mmus_CRIK LEQARMEVSQEDDKALQLLHDIR------------------------------------- let-502_Cele_ROCK ----------------------------------------------RAKMIENEKNSLST K08B12.5_Cele_GEK ----------------------------------------------FMVELENEKAELVQ DMPK2_Hsap_GEK ----------------------------------------------KLQCLEQEKVELSR DMPK1_Hsap_GEK ----------------------------------------------TPMELEAEQ----- CRIK_Hsap_CRIK LEQARMEVSQEDDKALQLLHDIR------------------------------------- ROCK1_Mmus_ROCK ----------------------------------------------AVSQIEKEKMLLQH ROCK2_Mmus_ROCK ----------------------------------------------TLRQLEREKALLQH MRCK_Spur_GEK ----------------------------------------------RINKLETEKTELTN ROCK_Spur_ROCK ----------------------------------------------KLMDKEREYVQLKH CRIK_Spur_CRIK LEQERNEQKDMDSKAVRLMGEIR------------------------------------- CC1G_07309_Ccin_GEK ----------------------------------------------------------QR AqueK004_Aque_CRIK LESERKERGTSNTKALQLLAEVRENNKIAKEMRDTENKELSEQVQSALVQL--------- AqueK005_Aque_GEK ------------------------------------------------------------ AqueK006_Aque_ROCK ----------------------------------------------KYNQSEKDLGLSRI ROCK2_Hsap_ROCK KNAEYQRKADH-E------ADK--KR----------NLEN---DVNSLKDQL-------- ROCK1_Hsap_ROCK RINEYQRKAEQ-E------NEK--RR----------NVEN---EVSTLKDQL-------- MRCKb_Hsap_GEK KLQESTQTVQS-LHGSSR-ALS--NS----------NRDK---EIKKLNEEI-------- MRCKa_Hsap_GEK KLQESTQTVQA-LQYSTVDGPL--TA----------SKDL---EIKNLKEEI-------- CG10522_Dmel_CRIK KIASEQRYEKQ-L------ADK--KQ----------ELAS---TLQKLDARE-------- rok_Dmel_ROCK NYKVAMQKVEQ-E------IEL--RK----------KTEA---LLVETQRNL-------- gek_Dmel_GEK --------------------P---------------SNN--------------------- MRCKb_Mmus_GEK KLQESTQTVQS-LHGSTR-ALG--NS----------NRDK---EIKRLNEEL-------- MRCKa_Mmus_GEK KLQESTQTVQA-LQYSTVDGPL--TA----------SKDL---EIKSLKEEI-------- DMPK2_Mmus_GEK KCQEPLHG-----------------P----------LQPQ---ELVRLQKEV-------- DMPK1_Mmus_GEK -------------------------------------------------LPV-------- CRIK_Mmus_CRIK ---EQSRKLQE-I------KEQEYQA----------QVEEMRLMMNQLEEDLVSARRRSD let-502_Cele_ROCK KISD-------------------------------------------------------- K08B12.5_Cele_GEK KLKEAQTIIAQHVAENPR-SEE--DR----------NYES---TIAQLKDEI-------- DMPK2_Hsap_GEK KHQEALHA-----------------P----------TDHR---ELEQLRKEV-------- DMPK1_Hsap_GEK -------------------------------------------------LLE-------- CRIK_Hsap_CRIK ---EQSRKLQE-I------KEQEYQA----------QVEEMRLMMNQLEEDLVSARRRSD ROCK1_Mmus_ROCK RINEYQRKVEQ-E------NEK--RR----------NIEN---EVSTLKDQL-------- ROCK2_Mmus_ROCK KNAEYQRKADH-E------ADK--KR----------NLEN---DVNSLKDQL-------- MRCK_Spur_GEK RVSELKSSG----------------G----------GEND---EVRRLQEEI-------- ROCK_Spur_ROCK KHTELARRAEQ-E------QEG--RK----------RVER---QVSHITDME-------- CRIK_Spur_CRIK ---QTSKKEQQ-L------RDEEFRA----------EVEDYKQAFSQMETDRQVAVKRAQ CC1G_07309_Ccin_GEK HLSPIPSTGPA-T------TPT--FPVVTPGFLTADA----------------------- AqueK004_Aque_CRIK ------------------------EQ----------ERVS---AVKRCQRAH-------- AqueK005_Aque_GEK --------------------PS--GP----------S--E---EEERLRAEV-------- AqueK006_Aque_ROCK DMKELTRKCEE-N------EET--IS----------QLRA---RINEAESQL-------- ROCK2_Hsap_ROCK ---EDLKKRNQNSQISTEKVNQLQRQLDETN-----AL-LRTESDTA-ARLRKTQAESS- ROCK1_Hsap_ROCK ---EDLKKVSQNSQLANEKLSQLQKQLEEAN-----DL-LRTESDTA-VRLRKSHTEMS- MRCKb_Hsap_GEK ---ERLKNKIAD-------SNRLERQLEDTV-----AL--RQEREDS-TQRL-------- MRCKa_Hsap_GEK ---EKLRKQVTE-------SSHLEQQLEEAN-----AV--RQELDDA-FRQI-------- CG10522_Dmel_CRIK ---LEFNAKFEECKHLSMKLQNYKDMLQQIK-----EQNLKSETNHE-EQRRQMAELYE- rok_Dmel_ROCK ---ENEQKTRARDLNINDKVVSLEKQLLEME-----QS-YKTETENT-QKLKKHNAELD- gek_Dmel_GEK -----------------------------------------SETPVD-SVQL-------- MRCKb_Mmus_GEK ---ERMKSKMAD-------SNRLERQLEDTV-----TL--RQEHEDS-THRL-------- MRCKa_Mmus_GEK ---EKLRKQVAE-------VNHLEQQLEEAN-----SV--RRELDDA-FRQI-------- DMPK2_Mmus_GEK ---QVLQEKLAE-------TL------RDSK-----AS--LSQTDGL----H-------- DMPK1_Mmus_GEK ---SDL------------------------------------------------------ CRIK_Mmus_CRIK LYESELRESRLAAEEFKRKANECQHKLMKAK-----DQ-GKPEVGEY-SKLEKINAEQQ- let-502_Cele_ROCK ----------------------LERELKDNK-----DK-LRHGADSD-AKVNELAVELRM K08B12.5_Cele_GEK ---QILNKRLED-------EALAQQQQKPKD-----EI--VAE---S-EKKL-------- DMPK2_Hsap_GEK ---QTLRDRLPE-------ML------RDKA------S--LSQTDGP----P-------- DMPK1_Hsap_GEK ---PHV------------------------------------------------------ CRIK_Hsap_CRIK LYESELRESRLAAEEFKRKATECQHKLLKAK-----DQ-GKPEVGEY-AKLEKINAEQQ- ROCK1_Mmus_ROCK ---EDLRKASQTSQLANEKLTQLQKQLEEAN-----DL-LRTESDTA-VRLRKSHTEMS- ROCK2_Mmus_ROCK ---EDLKKRNQSSQISTEKVNQLQKQLDEAN-----AL-LRTESDTA-ARLRKTQAESS- MRCK_Spur_GEK ---KSFKSRIAA-------SEAESKNTRDSYQAMAKEM--QSAEDEK-SSKI-------- ROCK_Spur_ROCK ---RELKEL----KLRSEKTTILERQVENLN-----KQ-LQTEGDQH-ARSKKMFGDHQ- CRIK_Spur_CRIK KLEAELRQKTQECEDFKAQVHNVKSKLTKVH-----F-------------------FHK- CC1G_07309_Ccin_GEK -----LATPLP--------SNRFADQH--------------------------------- AqueK004_Aque_CRIK ---EELKKKQIELDCCTAKVSDLKSRLAHAR-----ER-SKIDTAHLQDKLQRLSDDSK- AqueK005_Aque_GEK ---KSLKDELDK-------SR------RGTL-----SS--QKGHDDQ-ASKM-------- AqueK006_Aque_ROCK ---KGA-----------ESPSKLLTEIEQLK-----CE-LKSEFQNS-ASLKEATQKLK- ROCK2_Hsap_ROCK -------------KQIQQLESNNRDL----QDKNCL---LETAKLKLEKEFINLQSAL-- ROCK1_Hsap_ROCK -------------KSISQLESLNREL----QERNRI---LENSKSQTDKDYYQLQAIL-- MRCKb_Hsap_GEK -----RGLEKQHR----------------------V---VRQEKEELHKQLVEASERL-- MRCKa_Hsap_GEK -----KAYEKQIK----------------------T---LQQEREDLNKELVQASERL-- CG10522_Dmel_CRIK -------------QKLTDLRKKVRDS----QDTNRR---MTMEIKEIRTELDESISSS-- rok_Dmel_ROCK -------------FTVKSQEEKVRDM----VDMIDT---LQKHKEELGQENAELQALV-- gek_Dmel_GEK -----KALNDQLA----------------------A---LKQEKAELSKQHNEVFERL-- MRCKb_Mmus_GEK -----KGLEKQYR----------------------L---ARQEKEELHKQLVEASERL-- MRCKa_Mmus_GEK -----KASEKQIK----------------------T---LQQEREELNKELVQASERL-- DMPK2_Mmus_GEK -----ARSPAPNI----------------------Q---LQQEKDRLQQELTEAQAAL-- DMPK1_Mmus_GEK ------------------------------------------------------------ CRIK_Mmus_CRIK -------------LKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLHNREDS let-502_Cele_ROCK SKEYNSEMESELSKFRDKCEQLKEDL----RKKSGE---LAQEKNETQR----------- K08B12.5_Cele_GEK -----KELKERNK----------------------Q---LVMEKSEIQRELDNINDHL-- DMPK2_Hsap_GEK -----AGSPGQDS----------------------D---LRQELDRLHRELAEGRAGL-- DMPK1_Hsap_GEK ------------------------------------------------------------ CRIK_Hsap_CRIK -------------LKIQELQEKLEKAVKASTEATELLQNIRQAKERAERELEKLQNREDS ROCK1_Mmus_ROCK -------------KSISQLESLNREL----QERNRI---LENSKSQADKDYYQLQAVL-- ROCK2_Mmus_ROCK -------------KQIQQLESNNRDL----QDKNCL---LETAKLKLEKEFINLQSAL-- MRCK_Spur_GEK -----KTLERTSK----------------------L---IKQEKENLEREVEEIHERN-- ROCK_Spur_ROCK -------------KNYAHLEQEISEL----RDKYTR---ELNNKMMLDQEVIRMQTQL-- CRIK_Spur_CRIK -------------THLQNTKKRI------EIESTEVLQNTVTAGDRSQKILKKFSNHKDQ CC1G_07309_Ccin_GEK ------------------------------------------------------------ AqueK004_Aque_CRIK -------------KRIMTLHNEYAEL----QDRFTA---VNKELKQLKE----LQIKQ-- AqueK005_Aque_GEK -----KTLERAVR----------------------S---LKSEKNSLTEQVSDLKESL-- AqueK006_Aque_ROCK -------------QELLVKESVIDHL----ESRSKE---LSVERDRIDSDMITVQDEL-- ROCK2_Hsap_ROCK -ESERRDRT-----HGSEIIND-----------------LQ------------------- ROCK1_Hsap_ROCK -EAERRDRG-----HDSEMIGD-----------------LQ------------------- MRCKb_Hsap_GEK -KSQAKELK--------------------------------------------------- MRCKa_Hsap_GEK -KNQSKELK--------------------------------------------------- CG10522_Dmel_CRIK -KST-QEAKNATERNIEEILRR-----------------LNEEIASNN--EL-------- rok_Dmel_ROCK -VQEKNLRS-----QLKEMHKE-----------------AE------------------- gek_Dmel_GEK -KTQDSELQ--------------------------------------------------- MRCKb_Mmus_GEK -KSQTKELK--------------------------------------------------- MRCKa_Mmus_GEK -KNQSKELK--------------------------------------------------- DMPK2_Mmus_GEK -RVQDAELC--------------------------------------------------- DMPK1_Mmus_GEK ------------------------------------------------------------ CRIK_Mmus_CRIK SEGIKKKLV-----EAEERRHSLENKVKRLETMERRENRL-------------------- let-502_Cele_ROCK ------------------------------------------------------------ K08B12.5_Cele_GEK -DQVLVEKA--------------------------------------------------- DMPK2_Hsap_GEK -QAQEQELC--------------------------------------------------- DMPK1_Hsap_GEK ------------------------------------------------------------ CRIK_Hsap_CRIK SEGIRKKLV-----EAEERRHSLENKVKRLETMERRENRL-------------------- ROCK1_Mmus_ROCK -EAERRDRG-----HDSEMIGD-----------------LQ------------------- ROCK2_Mmus_ROCK -ESERRDRT-----HGSEIIND-----------------LQ------------------- MRCK_Spur_GEK -RQLNKEMK--------------------------------------------------- ROCK_Spur_ROCK -EEEQRGRS-----RMEDLKAE-----------------LEMG-GREPSMTTLEVNKEQE CRIK_Spur_CRIK LDELRVKLR-----EASEAEERTSRTAERL---RKEKTEM-------------------- CC1G_07309_Ccin_GEK ------------------------------------------------------------ AqueK004_Aque_CRIK -ENA-SSSARVS-----------------------------------V--TS-------- AqueK005_Aque_GEK -AAKEKELK--------------------------------------------------- AqueK006_Aque_ROCK -EKQHKLTA-----KLKTSNEE-----------------LK------------------- ROCK2_Hsap_ROCK ------------------------------------------------------------ ROCK1_Hsap_ROCK ------------------------------------------------------------ MRCKb_Hsap_GEK -------------------------DAHQQRKLAL------------------------- MRCKa_Hsap_GEK -------------------------DAHCQRKLAM------------------------- CG10522_Dmel_CRIK ------HAEKVKLETKLQLKENETQEVRAECHRLERELQLAECRCQLAESSLATQVSPYE rok_Dmel_ROCK ------------------------------------------------------------ gek_Dmel_GEK -------------------------DAISQRNIAM------------------------- MRCKb_Mmus_GEK -------------------------DAHQQRKRAL------------------------- MRCKa_Mmus_GEK -------------------------DAHCQRKLAM------------------------- DMPK2_Mmus_GEK -------------------------QAQNRQEEFL------------------------- DMPK1_Mmus_GEK ------------------------------------------------------------ CRIK_Mmus_CRIK -------------KDDIQTKSEQIQ-------QMA------------------------- let-502_Cele_ROCK ------------------------------------------------------------ K08B12.5_Cele_GEK -------------------------TVVQQRDDMQ------------------------- DMPK2_Hsap_GEK -------------------------RAQGQQEELL------------------------- DMPK1_Hsap_GEK ------------------------------------------------------------ CRIK_Hsap_CRIK -------------KDDIQTKSQQIQ-------QMA------------------------- ROCK1_Mmus_ROCK ------------------------------------------------------------ ROCK2_Mmus_ROCK ------------------------------------------------------------ MRCK_Spur_GEK -------------------------EAKSQGKLAM------------------------- ROCK_Spur_ROCK GSGWGGNNDKLHLQNKLMDKEREYVQLKHKHTELARR----------------------- CRIK_Spur_CRIK -------------REIVQEQCQSVQ-------EMR------------------------- CC1G_07309_Ccin_GEK ------------------------------------------------------------ AqueK004_Aque_CRIK ------SRELEELKVELETQKQLTDQYSAKVLECEKELSLKTVQCQEMEKSLDLEAT--- AqueK005_Aque_GEK -------------------------EGNKRYRESQ------------------------- AqueK006_Aque_ROCK ------------------------------------------------------------ ROCK2_Hsap_ROCK --------------------------------------GRICGLEEDLKNGKIL------ ROCK1_Hsap_ROCK --------------------------------------ARITSLQEEVKHLKHN------ MRCKb_Hsap_GEK ---------------------------------------------QEFSELNER------ MRCKa_Hsap_GEK ---------------------------------------------QEFMEINER------ CG10522_Dmel_CRIK TAPGSLTELNAIEDQLRADLLAAKESENHQKGRADQLQTLVTKLE--------------- rok_Dmel_ROCK --------------------------------------NKMQTLINDIERTMCR------ gek_Dmel_GEK ---------------------------------------------MEYSEVTEK------ MRCKb_Mmus_GEK ---------------------------------------------QEFSELNER------ MRCKa_Mmus_GEK ---------------------------------------------QEFMEINER------ DMPK2_Mmus_GEK ---------------------------------------------QRLWEAQER------ DMPK1_Mmus_GEK ------------------------------------------------------------ CRIK_Mmus_CRIK ---------------------------------------------DKILELEEK------ let-502_Cele_ROCK ------------------------------------------------------------ K08B12.5_Cele_GEK ---------------------------------------------AELADVGDS------ DMPK2_Hsap_GEK ---------------------------------------------QRLQEAQER------ DMPK1_Hsap_GEK ------------------------------------------------------------ CRIK_Hsap_CRIK ---------------------------------------------DKILELEEK------ ROCK1_Mmus_ROCK --------------------------------------ARITSLQEEVKHLKHN------ ROCK2_Mmus_ROCK --------------------------------------GRISGLEEDLKTGKAL------ MRCK_Spur_GEK ---------------------------------------------QEFTEINER------ ROCK_Spur_ROCK ---------------AEQEQEGRKR--------VERQVSHITDMERELKELKLRSEKTTI CRIK_Spur_CRIK ---------------------------------------------ASVMDLQQQ------ CC1G_07309_Ccin_GEK --------------------------------------PFVTPV-RPYTISNSP------ AqueK004_Aque_CRIK ------------------------------------------------------------ AqueK005_Aque_GEK ---------------------------------------------DELNRISDK------ AqueK006_Aque_ROCK --------------------------------------KLSETQNQSISSLKSR------ ROCK2_Hsap_ROCK ------------------------------------------------------------ ROCK1_Hsap_ROCK ------------------------------------------------------------ MRCKb_Hsap_GEK ------------------------------------------------------------ MRCKa_Hsap_GEK ------------------------------------------------------------ CG10522_Dmel_CRIK --QMLERFNEQS--LSPTKSHSSRKQEGETVGDMLERQNEKLEDKLAAVREQMIVERQAA rok_Dmel_ROCK ------------------------------------------------------------ gek_Dmel_GEK ------------------------------------------------------------ MRCKb_Mmus_GEK ------------------------------------------------------------ MRCKa_Mmus_GEK ------------------------------------------------------------ DMPK2_Mmus_GEK ------------------------------------------------------------ DMPK1_Mmus_GEK ------------------------------------------------------------ CRIK_Mmus_CRIK ------------------------------------------------------------ let-502_Cele_ROCK ------------------------------------------------------------ K08B12.5_Cele_GEK ------------------------------------------------------------ DMPK2_Hsap_GEK ------------------------------------------------------------ DMPK1_Hsap_GEK ------------------------------------------------------------ CRIK_Hsap_CRIK ------------------------------------------------------------ ROCK1_Mmus_ROCK ------------------------------------------------------------ ROCK2_Mmus_ROCK ------------------------------------------------------------ MRCK_Spur_GEK ------------------------------------------------------------ ROCK_Spur_ROCK LERQVENLNKQLQTEGD--QHAR---SKKMFGD-HQKNYAHLEQEISELRDK-------- CRIK_Spur_CRIK ------------------------------------------------------------ CC1G_07309_Ccin_GEK ------------------------------------------------------------ AqueK004_Aque_CRIK ------------------------------------------------------------ AqueK005_Aque_GEK ------------------------------------------------------------ AqueK006_Aque_ROCK ------------------------------------------------------------ ROCK2_Hsap_ROCK ------------------------------------------------------------ ROCK1_Hsap_ROCK ------------------------------------------------------------ MRCKb_Hsap_GEK ------------------------------------------------------------ MRCKa_Hsap_GEK ------------------------------------------------------------ CG10522_Dmel_CRIK RTANLSLWKVEKQLEEALSEKKLLARRMELTEDRIKKVQNASDEAQRMLKTSQEETRQRE rok_Dmel_ROCK ------------------------------------------------------------ gek_Dmel_GEK ------------------------------------------------------------ MRCKb_Mmus_GEK ------------------------------------------------------------ MRCKa_Mmus_GEK ------------------------------------------------------------ DMPK2_Mmus_GEK ------------------------------------------------------------ DMPK1_Mmus_GEK ------------------------------------------------------------ CRIK_Mmus_CRIK ------------------------------------------------------------ let-502_Cele_ROCK ------------------------------------------------------------ K08B12.5_Cele_GEK ------------------------------------------------------------ DMPK2_Hsap_GEK ------------------------------------------------------------ DMPK1_Hsap_GEK ------------------------------------------------------------ CRIK_Hsap_CRIK ------------------------------------------------------------ ROCK1_Mmus_ROCK ------------------------------------------------------------ ROCK2_Mmus_ROCK ------------------------------------------------------------ MRCK_Spur_GEK ------------------------------------------------------------ ROCK_Spur_ROCK -------------YTRELNNKMMLDQEVIRMQTQL------------------EEEQRGR CRIK_Spur_CRIK ------------------------------------------------------------ CC1G_07309_Ccin_GEK ------------------------------------------------------------ AqueK004_Aque_CRIK ---------LK------------------------QSLQDKYDAILKELK---------- AqueK005_Aque_GEK ------------------------------------------------------------ AqueK006_Aque_ROCK ------------------------------------------------------------ ROCK2_Hsap_ROCK ---------------------------LAKVELEKRQLQERFTDLEKEKSNMEIDMTYQL ROCK1_Hsap_ROCK ---------------------------LEKVEGERKEAQDMLNHSEKEKNNLEIDLNYKL MRCKb_Hsap_GEK ---------------------------MAELRAQKQKVSRQLRDKEEEMEVA----TQKV MRCKa_Hsap_GEK ---------------------------LTELHTQKQKLARHVRDKEEEVDLV----MQKV CG10522_Dmel_CRIK SRIEELKQELA------------------------------------------------- rok_Dmel_ROCK ---------------------------EQKAQEDNRALLEKISDLEKAHAGLD----FEL gek_Dmel_GEK ---------------------------LSELRNQKQKLSRQVRDKEEELDGA----MQKN MRCKb_Mmus_GEK ---------------------------MSELRSLKQKVSRQLRDKEEEMEVA----MQKI MRCKa_Mmus_GEK ---------------------------LTELHTQKQKLARHVRDKEEEVDLV----MQKA DMPK2_Mmus_GEK ---------------------------EAAAASQIQALNSQL------------------ DMPK1_Mmus_GEK ---------------------------------QGLDLQPPV------------------ CRIK_Mmus_CRIK ---------------------------HREAQVSAQHLEVHLKQKEQHYEE-------KI let-502_Cele_ROCK ------------------------------VFQQKKDADEAFAEIKRDYE---------- K08B12.5_Cele_GEK ------------------------------------------------------------ DMPK2_Hsap_GEK ---------------------------EAATASQTRALSSQL------------------ DMPK1_Hsap_GEK ---------------------------------QAPSLEPSV------------------ CRIK_Hsap_CRIK ---------------------------HREAQVSAQHLEVHLKQKEQHYEE-------KI ROCK1_Mmus_ROCK ---------------------------LERVEGERKEAQDMLNHSEKEKNNLEIDLNYKL ROCK2_Mmus_ROCK ---------------------------LAKVELEKRQLQEKLTDLEKEKSNMEIDMTYQL MRCK_Spur_GEK ---------------------------YADIMSQKQKLSRDLRDKEEEIEVV----SQKV ROCK_Spur_ROCK SRMEDLKAELERQNAQATQEMNRLKQGESRSIATMQNHQESIIILEKTKASLE----FDL CRIK_Spur_CRIK ---------------------------LQESQVTFQHVSVELNNKEQVCM---------- CC1G_07309_Ccin_GEK ---------------------------MN----------------------T----IRRT AqueK004_Aque_CRIK ------------------------------------------------------------ AqueK005_Aque_GEK ---------------------------MTDYRSQKRELSRALREKEEEYDEI----ASKV AqueK006_Aque_ROCK ---------------------------LSEISDENQRIKRSQAESEKDKTSLE----LNL ROCK2_Hsap_ROCK KVIQQSLEQEEAEHKAT-K--ARLADKNKIYESIE---EAKSEAMKEMEKKLLEERTL-- ROCK1_Hsap_ROCK KSLQQRLEQEVNEHKVT-K--ARLTDKH---QSIE---EAKSVAMCEMEKKLKEEREA-- MRCKb_Hsap_GEK DAMRQEMRRAEKLRKEL-E--AQL----------D---DAVAEA--SKERKLR------- MRCKa_Hsap_GEK ESLRQELRRTERAKKEL-E--VHT----------E---ALAAEA--SKDRKLR------- CG10522_Dmel_CRIK ------------------------------------------------------------ rok_Dmel_ROCK KAAQGRYQQEVKAHQETEK--SRLVSR-------E---EANLQEVKALQSKLNEEKSA-- gek_Dmel_GEK DSLRNELRKSDKTRREL-E--LHI----------E---DAVIEA--AKEKKLR------- MRCKb_Mmus_GEK DSMRQDLRKSEKSRKEL-E--ARL----------E---DAAAEA--SKERKLR------- MRCKa_Mmus_GEK ESLRQELRRAERAKKEL-E--VHT----------E---ALIAEA--SKDKKLR------- DMPK2_Mmus_GEK -------EEAWVVRREL-E--GQV----------T---TLSQEV--TR------------ DMPK1_Mmus_GEK -------SPPD-QVAEE-ADLVAV----------P---APVAEA--ET------------ CRIK_Mmus_CRIK KVLDNQIKKDL-------------ADKESLENMMQ---RHEEEA--HEKGKIL------- let-502_Cele_ROCK -LLQTRE----------------------------------NEKSVQLKKALDERKENGA K08B12.5_Cele_GEK ---------------------------------------LLTEK--DSVKRLQ------- DMPK2_Hsap_GEK -------EEARAAQREL-E--AQV----------S---SLSRQV--TQ------------ DMPK1_Hsap_GEK -------SPQD-ETAEV-A--VPA----------A---VPAAEA--EA------------ CRIK_Hsap_CRIK KVLDNQIKKDL-------------ADKETLENMMQ---RHEEEA--HEKGKIL------- ROCK1_Mmus_ROCK KSIQQRLEQEVNEHKVT-K--ARLTDKH---QSIE---EAKSVAMCEMEKKLKEEREA-- ROCK2_Mmus_ROCK KVIQQSLEQEEAEHKTT-K--ARLADKNKIYESIE---EAKSEAMKEMEKKLLEERSL-- MRCK_Spur_GEK DSQRADIRKHEQANKEL-E--ALQ----------E---DFQVEI--AREKKLR------- ROCK_Spur_ROCK KALQNTHEQGVKEHRDA-M--AAVNAEK---KRIT---R---TQEDELQKTLVQEREM-- CRIK_Spur_CRIK LGIHHKIKAEK-------------NNKKKKENQRREWNKHRMLD--HEDCIIL------- CC1G_07309_Ccin_GEK NTIRRTVGRREVSDREA-M--KQL----------V---DCIGM----------------- AqueK004_Aque_CRIK ------------------------------------------------------------ AqueK005_Aque_GEK DSYRKTAKESEREKRSL-L--NEL----------D---DAKAAV--SQEKRQK------- AqueK006_Aque_ROCK KSLQQRYDQMSKSHEQL-S--VQFKSTS---TSVE---ES----VSQLRSQLDSEVSA-- ROCK2_Hsap_ROCK KQKV--ENLLLEAEKRCSLLDC----------DLKQSQQKIN-ELLKQK----------- ROCK1_Hsap_ROCK REKA--ENRVVQIEKQCSMLDV----------DLKQSQQKLE-HLTGNK----------- MRCKb_Hsap_GEK -EHS--ENFCKQMESELEALKVKQG-GRGAG-ATLEHQQEIS-K---------------- MRCKa_Hsap_GEK -EQS--EHYSKQLENELEGLKQKQI-SYSPGVCSIEHQQEIT-K---------------- CG10522_Dmel_CRIK ------------------------------------------------------------ rok_Dmel_ROCK RIKA--DQHSQEKERQLSMLSV----------DYRQIQLRLQ-KLEGEC----------- gek_Dmel_GEK -EHA--EDCCRQLQMELRKGSSSVE-TTMP------LSISSE-M---------------- MRCKb_Mmus_GEK -EHS--ESFCKQMERELEALKVKQG-GRGPG-AASEHQQEIS-K---------------- MRCKa_Mmus_GEK -EQS--EHYSKQLENELEGLKQKQI-SYSPGICSIEHQQEIT-K---------------- DMPK2_Mmus_GEK ------------------------------------------------------------ DMPK1_Mmus_GEK ------------------------------------------------------------ CRIK_Mmus_CRIK -SEQ--KAMINAMDS-----------------KIRSLEQRIV-ELSEANKLAANSSLFTQ let-502_Cele_ROCK YQQSVAKATDAEWERKMQFYEK-----------------QLE-HAN--D----------- K08B12.5_Cele_GEK -DEA--EKAKKQVADFEEKLKEIET----EKIALIKKQEEVTIE---------------- DMPK2_Hsap_GEK ------------------------------------------------------------ DMPK1_Hsap_GEK ------------------------------------------------------------ CRIK_Hsap_CRIK -SEQ--KAMINAMDS-----------------KIRSLEQRIV-ELSEANKLAANSSLFTQ ROCK1_Mmus_ROCK REKA--ENRVVETEKQCSMLDV----------DLKQSQQKLE-HLTENK----------- ROCK2_Mmus_ROCK KQKV--ENLLLEAEKRCSILDC----------DLKQSQQKLN-ELLKQK----------- MRCK_Spur_GEK -QQS--DQNIKQLQDELEGLKVNSV-GRAKP-DTDKYEKEVA-R---------------- ROCK_Spur_ROCK R---------VQVDKQNSILEL----------DLKQAQQKIE-RMENMI----------- CRIK_Spur_CRIK -IEK--KLFIYLFEL-----------------SIKALQQEVM-ELKMI-MLEI-CFCF-- CC1G_07309_Ccin_GEK -----------------------------------SARKK-------------------- AqueK004_Aque_CRIK ------------------------------------------------------------ AqueK005_Aque_GEK -NRL--EKLKQELEDEISTLRSKHRRDTSTGQDTQELQKNIE-K---------------- AqueK006_Aque_ROCK RQTA--ERTASDLEHQTSFLRL----------DLKQTNEEVS-DLKQQI----------- ROCK2_Hsap_ROCK ------DVLNEDVRNLTLKIEQETQKRCL-TQNDLKMQTQQ-VNTLKMSEK-QLKQENNH ROCK1_Hsap_ROCK ------ERMEDEVKNLTLQLEQESNKRLL-LQNELKTQAFE-ADNLKGLEK-QMKQEINT MRCKb_Hsap_GEK --------IKSELEKKVLFYEEELVRREASHVLEVKNVKKEV----HDSES-HQLALQKE MRCKa_Hsap_GEK --------LKTDLEKKSIFYEEELSKREGIHANEIKNLKKEL----HDSEG-QQLALNKE CG10522_Dmel_CRIK -------AAKRDVLKEHRQWEKAEQERMK-CKSEIIEHLAN-VHRL---EQ-QETELRQK rok_Dmel_ROCK ------RQESEKVAALQSQLDQEHSKRNA-LLSELSLHSSE-VAHLRSREN-QLQKELST gek_Dmel_GEK --------SSYEIERLELQFSEKLSHQQTRHNMELEALREQF----SELEN-ANLALTKE MRCKb_Mmus_GEK --------IRSELEKKVLFYEEELVRREASHVLEVKNVKKEV----HDSES-HQLALQKE MRCKa_Mmus_GEK --------LKTDLEKKSIFYEEEISKREGIHASEIKNLKKEL----HDSEG-QQLALNKE DMPK2_Mmus_GEK --------LQGQCKQE-------SSQAKTVHAAPETNGIG-S----PEGQS-QEAQLRKE DMPK1_Mmus_GEK ---------------------------------------------------------T-- CRIK_Mmus_CRIK RNMKAQEEMISELRQQKFYLETQAGKLEAQ-NRKLEEQLEK-ISHQDHSDKSRLLELETR let-502_Cele_ROCK ------------------ERKREEQKRTA-AEFDQSRVARK-LAGIEANYE-LLQNDYKS K08B12.5_Cele_GEK --------ARKSVETDDHLS------------EEVVAAKNTI----ASLQA-TNEERETE DMPK2_Hsap_GEK --------LQGQWEQRL----EESSQAKTIHTASETNGMG-P----PEGGP-QEAQLRKE DMPK1_Hsap_GEK ---------------------------------------------------------E-- CRIK_Hsap_CRIK RNMKAQEEMISELRQQKFYLETQAGKLEAQ-NRKLEEQLEK-ISHQDHSDKNRLLELETR ROCK1_Mmus_ROCK ------ERMEDEVKNLALQLEQESNKRLL-LQNELKTQAFE-ADNLKGLEK-QMKQEINT ROCK2_Mmus_ROCK ------DVLNEDVRNLTLKIEQETQKRCL-MQNDLKMQTQQ-VNTLKMSEK-QIKQENNH MRCK_Spur_GEK --------LKQEMEKKEVQYAEGVAKEKSRHTIEEKILKEQV----NENED-KIVSMRRE ROCK_Spur_ROCK ------KMEEQKTKEKMLQLEQEEQRHRF-TQNDLKASKQT-SSGYQTDIK-RLRNELNT CRIK_Spur_CRIK LCRRVEAEKFSDLNQDRLYLQTQVSRLEF------------------------------- CC1G_07309_Ccin_GEK ------------------------------------------------------------ AqueK004_Aque_CRIK ------------------CYE-----------------------------E--------- AqueK005_Aque_GEK --------LQAQLQEKDSDHSEAVKSLEAKHIAEVQKLKELL----ATSES-TNTELHNE AqueK006_Aque_ROCK ------HDLEES-------LRQEKRLRER-EEAEAKKQQKELTDRLAGREQ-DIRAQLQE ROCK2_Hsap_ROCK LMEMKMNLEKQ-------NAELRK-ERQ-------------------------------D ROCK1_Hsap_ROCK LLEAKRLLEFE-------LAQLTK-QYR-------------------------------G MRCKb_Hsap_GEK ILMLKDKLEKS-------KRERHN-EME-------------------------------E MRCKa_Hsap_GEK IMILKDKLEKT-------RRESQS-ERE-------------------------------E CG10522_Dmel_CRIK LRQIQSRFDGVTLEQKNTIRELQE-EREKSRKANDSCLVLQKELKQLTDNFQRLKYACSI rok_Dmel_ROCK QREAKRRFEED-------LTQLKS-THH-------------------------------E gek_Dmel_GEK LQQTQERLKYT-------QMESIT-DSA-------------------------------E MRCKb_Mmus_GEK VLMLKDKLEKS-------KRERHS-EME-------------------------------E MRCKa_Mmus_GEK ILVLKDKLEKT-------RRESQS-ERE-------------------------------E DMPK2_Mmus_GEK VAALREQLEHA-------CSQGISVGKE-------------------------------E DMPK1_Mmus_GEK ------------------------------------------------------------ CRIK_Mmus_CRIK LREVSLEHEEQ-------KLELKR-QLT-------------------------------E let-502_Cele_ROCK MKEARKDLERD-------LQDVIT-EKR-------------------------------R K08B12.5_Cele_GEK IKKLKQRMDEE-------RASHTA-QSE-------------------------------Q DMPK2_Hsap_GEK VAALREQLEQA-------HSHRPS-GKE-------------------------------E DMPK1_Hsap_GEK ------------------------------------------------------------ CRIK_Hsap_CRIK LREVSLEHEEQ-------KLELKR-QLT-------------------------------E ROCK1_Mmus_ROCK LLEAKRLLEFE-------LAQLTK-QYR-------------------------------G ROCK2_Mmus_ROCK LMEMKMNLEKQ-------NTELRK-ERQ-------------------------------D MRCK_Spur_GEK ITSLQDKLGRL-------QTTSTED-QHAK-----------------------------M ROCK_Spur_ROCK IKEQGKNFEEA-------LEKSKS-IAS-------------------------------L CRIK_Spur_CRIK ------------------------------------------------------------ CC1G_07309_Ccin_GEK ------------------------------------------------------------ AqueK004_Aque_CRIK ---------------------------------------AEGEEPKTTPTSS-------N AqueK005_Aque_GEK NNDLQVRLTKV-------RNRTIS-ELN-------------------------------E AqueK006_Aque_ROCK LKNEKQKMEDT-------IYRLKS-EGK-------------------------------A ROCK2_Hsap_ROCK ADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKE------------------ ROCK1_Hsap_ROCK NEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNR---E------------------ MRCKb_Hsap_GEK AVGTIK----------------------------------DK------------------ MRCKa_Hsap_GEK FESEFK----------------------------------QQ------------------ CG10522_Dmel_CRIK TDSQLTEVETMLKSEQERNKSQKSQLDTLHEKLRERNDQL-------------------- rok_Dmel_ROCK ALANNRELQAQLEAEQCFSRLYKTQANENREESAER------------------------ gek_Dmel_GEK TLLELK----------------------------------KQ------------------ MRCKb_Mmus_GEK AIGTVK----------------------------------DK------------------ MRCKa_Mmus_GEK FENEFK----------------------------------QQ------------------ DMPK2_Mmus_GEK V----------------------------------------------------------- DMPK1_Mmus_GEK ------------------------------------------------------------ CRIK_Mmus_CRIK LQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDA let-502_Cele_ROCK LEIRVEQLMDSRNTDERVLSLCQDELVESQEEAKY------------------------- K08B12.5_Cele_GEK EMKQLE----------------------------------AH------------------ DMPK2_Hsap_GEK A----------------------------------------------------------- DMPK1_Hsap_GEK ------------------------------------------------------------ CRIK_Hsap_CRIK LQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAHRDEIQRKFDA ROCK1_Mmus_ROCK NEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNR---E------------------ ROCK2_Mmus_ROCK ADGQMKELQDQLEAEQYFSTLYKTQVRELKEENEEKTKLCKE------------------ MRCK_Spur_GEK KMDDMK----------------------------------RN------------------ ROCK_Spur_ROCK NGSQISDLQEQLEAEHTFNALYKSQNQVLSEELMESKQEYQQ------------------ CRIK_Spur_CRIK ----------ELKQAQMARSSLTDQ-------------------------SKEMQSKLDV CC1G_07309_Ccin_GEK ------------------------------------------------------------ AqueK004_Aque_CRIK TDDNISSLQEELLIQKQLTDEYNFKVLEYEKELGMKTVEC-------------------- AqueK005_Aque_GEK GMKEKV----------------------------------DK------------------ AqueK006_Aque_ROCK ADASLKETLEELEQERKLTNSLRGRINNMGEAGV-------------------------- ROCK2_Hsap_ROCK ----------LQQKKQELQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMK ROCK1_Hsap_ROCK ----------NLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQ----- MRCKb_Hsap_GEK ----------YERERAMLFDENKKLTAENEKLCSFVDKLTAQNRQLEDELQDLA------ MRCKa_Hsap_GEK ----------YEREKVLLTEENKKLTSELDKLTTLYENLSIHNQQLEEEVKDLA------ CG10522_Dmel_CRIK ----------------------------------------------TDLRKQLT------ rok_Dmel_ROCK -----------LSKIEDLEEERVSLKHQVQVAVARADSEALARSIAEETVADLEKEKTIK gek_Dmel_GEK ----------HDLEKSSWFEEKQRLSSEVNLKSKSLKELQAED---DEIFKELR------ MRCKb_Mmus_GEK ----------YERERAMLFDENKKLTAENEKLCSFVDKLTAQNRQLEDELQDLA------ MRCKa_Mmus_GEK ----------YEREKVLLTEENKKLTSELDKLTSLYESLSLRNQHLEEEVKDLA------ DMPK2_Mmus_GEK --------------LCRLQEENQRLSREQERLAGELELELQSKQRLE------G------ DMPK1_Mmus_GEK ------------------------------------------------------------ CRIK_Mmus_CRIK LRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAN---------DEIV---- let-502_Cele_ROCK --------------------KEDGLRGKIDGFKHELENEKMKTQTLEENLLVADKERGML K08B12.5_Cele_GEK ----------YERAQKMLQDNVEQMNVE--------------NRGLRDEIEKLS------ DMPK2_Hsap_GEK --------------LCQLQEENRRLSREQERLEAELAQEQESKQRLE------G------ DMPK1_Hsap_GEK ------------------------------------------------------------ CRIK_Hsap_CRIK LRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQLDEASGAN---------DEIV---- ROCK1_Mmus_ROCK ----------NLRKIQELQSEKETLSTQLDLAETKAESEQLARGILEEQYFELTQ----- ROCK2_Mmus_ROCK ----------LQQKKQDLQDERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMK MRCK_Spur_GEK ----------YERTKALINDDKTKLSQDLDKTLLEKERLQRELRLSEEKLEEMS------ ROCK_Spur_ROCK ----------LQQDYHQLSNEKESLAAQLELTLTKADSEQLARTIAEDQYTDLEREKTMV CRIK_Spur_CRIK LRERSTIITSLETQLREKTGQCSTISKEKQELMERCETFAMEK---------GRLV---- CC1G_07309_Ccin_GEK ---------------VLESGRKPKILTSYNLSRSLRRRPSVRSFSLTDKTTDGA------ AqueK004_Aque_CRIK ----------------------------------------------QEMTEALK------ AqueK005_Aque_GEK ----------YEKDKIQLSEEKRELSLQVESLTTKLEESKKIQQQQEEDLKDIK------ AqueK006_Aque_ROCK ----------NEKEITRLKSENSELNSKLENVT-------QIKAAAEAKLADFEREKMMI ROCK2_Hsap_ROCK ELEIKEMM---ARHKQEL--TEKDA-------TIASLEETNRTLTSDVANLANEKE-ELN ROCK1_Hsap_ROCK --ESKKAA---SRNRQEI--TDKDH-------TVSRLEEANSMLTKDIEILRRENE-ELT MRCKb_Hsap_GEK --AKKESV---AHWEAQI--AEIIQWVSDEKDARGYLQALASKMTEELEALRSS---SLG MRCKa_Hsap_GEK --DKKESV---AHWEAQI--TEIIQWVSDEKDARGYLQALASKMTEELEALRNS---SLG CG10522_Dmel_CRIK --TVESE-KRLAEQRAQVLASEIDELRLNLKEQQKKLVAQQDQLVEQTNALFAT--Q--- rok_Dmel_ROCK ELELKDFV---MKHRNEI--NAKEA-------ALATLKEAENELHKKLGQKAAEYE-DLV gek_Dmel_GEK --MKREAI---TLWERQM--AEIIQWVSDEKDARGYLQALATKMTEELEYLKHVGTF-NN MRCKb_Mmus_GEK --SKKESV---AHWEAQI--AEIIQWVSDEKDARGYLQALASKMTEELETLRSS---SLG MRCKa_Mmus_GEK --DKKESV---AHWEAQI--TEIIQWVSDEKDARGYLQALASKMTEELEALRNS---SLG DMPK2_Mmus_GEK --ERRETE---SNWEAQI--ADILSWVNDEKVSRGYLQALATKMAEELESLRNVGTQTLP DMPK1_Mmus_GEK ------------------------------------------------------------ CRIK_Mmus_CRIK --QLRSEV---DHLRREI--TEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALND-ELL let-502_Cele_ROCK KMEVQELM---QRHKWEI--TNKDQ-------TLKHLETQLDEIKQ-------------- K08B12.5_Cele_GEK --QQMAALPRGGLNEQQL--HEIFNWVSEEKATREEMENLTRKITGEVESLKNNSPLTTS DMPK2_Hsap_GEK --ERRETE---SNWEAQL--ADILSWVNDEKVSRGYLQALATKMAEELESLRNVGTQTLP DMPK1_Hsap_GEK ------------------------------------------------------------ CRIK_Hsap_CRIK --QLRSEV---DHLRREI--TEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALND-ELL ROCK1_Mmus_ROCK --ESKKAA---SRNRQEI--TDKDH-------TVSRLEETNSVLTKDIEMLRKENE-ELN ROCK2_Mmus_ROCK ELEIKEMM---ARHKQEL--TEKDT-------TIASLEETNRTLTSDVANLANEKE-ELN MRCK_Spur_GEK --RNKDSV---AHWEAQI--AEIIQWVSDEKDARGYLQALASKMTDELESIKVS---GIV ROCK_Spur_ROCK ELEYKEQI---QRHKCTL--NDKNS-------HLNKLEDDKTQLNNRIMTLNTEKD-ELN CRIK_Spur_CRIK --TQNQQM---DHIIILI--TKKNMWIIFYSQNINMLKTTCTMLEEQVIDLETITE-RLE CC1G_07309_Ccin_GEK --PNTGAT----------------NSNGTRKELRFYPTVMPIPMTEYTDD--------GG AqueK004_Aque_CRIK --LEQN---------------------------------LNNKLYDD------------- AqueK005_Aque_GEK --NQKELL---SQWEHQI--AEIVQLVSDEKNARSYLQTVAKGLVEDVESLRAS---SSS AqueK006_Aque_ROCK ELDIKEII---ARHKTEV--TERMA-------WSSKMKDQLIIMENKLNQKNLENE-QLQ ROCK2_Hsap_ROCK --NKLKDVQEQLSR---------------------------------------------- ROCK1_Hsap_ROCK --EKMKKAEEEYKL---------------------------------------------- MRCKb_Hsap_GEK --SRTLDPLWKVRR---------------------------------------------- MRCKa_Hsap_GEK --TRATDMPWKMRR---------------------------------------------- CG10522_Dmel_CRIK ERAELLDG---------------------------------------------------- rok_Dmel_ROCK --QQHKKQQEELAL---------------------------------------------- gek_Dmel_GEK --NGVDNKNWRNRR---------------------------------------------- MRCKb_Mmus_GEK --SRTLDPLWKVRR---------------------------------------------- MRCKa_Mmus_GEK --TRATDMPWKMRR---------------------------------------------- DMPK2_Mmus_GEK --TRPLDHQWKARR---------------------------------------------- DMPK1_Mmus_GEK ------------------------------------------------------------ CRIK_Mmus_CRIK --EK--ERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAV let-502_Cele_ROCK ----------QSKI---------------------------------------------- K08B12.5_Cele_GEK NYIQNTPSGWGSRR---------------------------------------------- DMPK2_Hsap_GEK --ARPLDHQWKARR---------------------------------------------- DMPK1_Hsap_GEK ------------------------------------------------------------ CRIK_Hsap_CRIK --EK--ERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAV ROCK1_Mmus_ROCK --ERMRTAEEEYKL---------------------------------------------- ROCK2_Mmus_ROCK --NKLKDSQEQLSK---------------------------------------------- MRCK_Spur_GEK --GAAREKSWQSR----------------------------------------------- ROCK_Spur_ROCK --KKLKESSEAQEA---------------------------------------------- CRIK_Spur_CRIK --TR--LEECRQARDGAKESLQEKEERLRAVSKASEDAQQARSRAEEKIKESR------- CC1G_07309_Ccin_GEK --TE-------------------------------------------------------- AqueK004_Aque_CRIK ------------------------------------------------------------ AqueK005_Aque_GEK --IGKQKEVWVERR---------------------------------------------- AqueK006_Aque_ROCK --DNLKRALIRLDD---------------------------------------------- ROCK2_Hsap_ROCK ----------------------------------L---KDEEISAAAIKAQF-----EKQ ROCK1_Hsap_ROCK ----------------------------------E---KEEEIS--NLKAAF-----EKN MRCKb_Hsap_GEK ----------------------------------SQKL-DMS-ARLELQSAL-----EAE MRCKa_Hsap_GEK ----------------------------------FAKL-DMS-ARLELQSAL-----DAE CG10522_Dmel_CRIK ----------------------------------------QN-AN------YEAQTADSN rok_Dmel_ROCK ----------------------------------MRSSKDEEIT--K----L-----LDK gek_Dmel_GEK ----------------------------------SQKL-DKM-ELLNLQSAL-----QRE MRCKb_Mmus_GEK ----------------------------------SQKL-DMS-ARLELQSAL-----EAE MRCKa_Mmus_GEK ----------------------------------FAKL-DMS-ARLELQSAL-----DAE DMPK2_Mmus_GEK ----------------------------------LQKM-EAS-ARLELQSAL-----EAE DMPK1_Mmus_GEK -----------------------------------------V-TLQQLQEAL-----EEE CRIK_Mmus_CRIK KEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAML-EMN-AR-SLQQKL-----ETE let-502_Cele_ROCK ----------------------------------ES-S-EQESNDKQTIADL-----RKK K08B12.5_Cele_GEK ----------------------------------MNNV-ARK-DGLDLQRQL-----QAE DMPK2_Hsap_GEK ----------------------------------LQKM-EAS-ARLELQSAL-----EAE DMPK1_Hsap_GEK -----------------------------------------V-TLRELQEAL-----EEE CRIK_Hsap_CRIK KEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAML-EMN-AR-SLQQKL-----ETE ROCK1_Mmus_ROCK ----------------------------------K---KEEEIN--NLKAAF-----EKN ROCK2_Mmus_ROCK ----------------------------------L---KDEEMSAAAIKAQF-----EKQ MRCK_Spur_GEK ------------------------------------------------------------ ROCK_Spur_ROCK ----------------------------------ME-TKHQEME--KQMEQN-----KKL CRIK_Spur_CRIK ---------------------MSVVLQLSEVEKHRALL-EVA-AK-ELKQRY-----EDE CC1G_07309_Ccin_GEK ------------------------------------------------------------ AqueK004_Aque_CRIK ------------------------------------------------------------ AqueK005_Aque_GEK ----------------------------------TLRR-DKL-ERVEMQQNF-----ENE AqueK006_Aque_ROCK ----------------------------------YQTF-DETR-DDEI-KKM-----SKQ ROCK2_Hsap_ROCK LL-----TERTLKTQAVNKLAEIMNRKEP---VK---RGND---------TDVRRKEKEN ROCK1_Hsap_ROCK IN-----TERTLKTQAVNKLAEIMNRKDFKIDRK---KANT---------QDLRKKEKEN MRCKb_Hsap_GEK IRAKQLVQEELRKVKDANL-------------------TLE---------SKLKDSEAKN MRCKa_Hsap_GEK IRAKQAIQEELNKVKASNI-------------------ITE---------CKLKDSEKKN CG10522_Dmel_CRIK RE-MVSLKEENARI-----LSELFHKKEE-V------GNLQ---------AEIRGLESAQ rok_Dmel_ROCK CK-----NEVLLKQVAVNKLAEVMNRRDSDLPKQKNKARST---------AELRKKEKEM gek_Dmel_GEK IQAKNMISDELSQTRSDLI-------------------STQ---------KEVRDYKKRY MRCKb_Mmus_GEK IRAKQLVQEELRKVKDSSL-------------------AFE---------SKLKESEAKN MRCKa_Mmus_GEK IRAKQAIQEELNKVKASNI-------------------LTE---------CKLKDSEKKN DMPK2_Mmus_GEK IRAKQSLQEQLTQVQEAQR-------------------QAE---------RRLQEAEKQS DMPK1_Mmus_GEK VLTRQSLSRELEAIRTANQ-------------------NFS---------SQLQEAEVRN CRIK_Mmus_CRIK RELKQRLLEEQAKLQQQMD---------LQKNHI---FRLTQGLQEALDRADLLKTERSD let-502_Cele_ROCK LD-----LEKAHKKAVINKLEEEMAKRQPL--KKGEKGVTK---------SALIKKEREI K08B12.5_Cele_GEK IDAKLKLKAELKNSQEQYL-------------------TSA---------ARLDDTEKRM DMPK2_Hsap_GEK IRAKQGLQERLTQVQEAQL-------------------QAE---------RRLQEAEKQS DMPK1_Hsap_GEK VLTRQSLSREMEAIRTDNQ-------------------NFA---------SQLREAEARN CRIK_Hsap_CRIK RELKQRLLEEQAKLQQQMD---------LQKNHI---FRLTQGLQEALDRADLLKTERSD ROCK1_Mmus_ROCK IS-----TERTLKTQAVNKLAEIMNRKDFKIDRK---KANT---------QDLRKKEKEN ROCK2_Mmus_ROCK LL-----NERTLKTQAVNKLAEIMNRKEP---VK---RGSD---------TDVRRKEKEN MRCK_Spur_GEK --------------------------------------------------SKLRSSEARN ROCK_Spur_ROCK LG-----EEKLKKEQAVSKLAEIMNRKDFNPSSRKGKKVSQ---------AAMNQKEKEC CRIK_Spur_CRIK QED-----------------------------IN---FQLTQALEEALSKGEYIKEQKQE CC1G_07309_Ccin_GEK ------------------------------------------------------------ AqueK004_Aque_CRIK ---IYHLRQEHGKL------------QAA-H------MKLS---------KQLKTQESRA AqueK005_Aque_GEK LRAKQRVEEELTHIRTQLA-------------------HTE---------SDVVQLKAQI AqueK006_Aque_ROCK LE-----TEKMMKKEAINKLTRIMLERKSLPS--NVKK--P---------EPRRAHEREI ROCK2_Hsap_ROCK RKLHMELKSE-REKLTQQMIKYQKELNE-----------MQAQIAEE--------SQI-- ROCK1_Hsap_ROCK RKLQLELNQE-REKFNQMVVKHQKELND-----------MQAQLVEE--------CAH-- MRCKb_Hsap_GEK RELLEEMEIL-KKKMEEK----------FRADTGLKLPDFQDSIFEYFNTA----PLA-- MRCKa_Hsap_GEK LELLSEIEQL-IKDTEE-----------LRSEKGIEHQDSQHSFLAFLNTP----TDA-- CG10522_Dmel_CRIK ANLHAEIDS-LQDTLAEKEQFYVQRD--IKSNATLAQHKKLI---DYLQLKVEDLSAKKK rok_Dmel_ROCK RRLQQELSQE-RDKFNQLLLKHQ----D-----------LQQLCAEE--------QQL-- gek_Dmel_GEK DSILHDFQKK-ETELRDL-----------Q-KGGLEYSES---FLNKSTHH----GLS-- MRCKb_Mmus_GEK RELLEEMQSL-RKRMEEK----------FRADTGLKLPDFQDSIFEYFNTA----PLA-- MRCKa_Mmus_GEK LELLSEIEQL-IKDTEE-----------LRSEKGIEHQDSQHSFLAFLNTP----TDA-- DMPK2_Mmus_GEK QALQQEVAEL-REELQAR------------GPGDARPSTSLIPLLSFWNTE----K---- DMPK1_Mmus_GEK RDLEAHVRQL-QERMEML-----------QAPG--------------------------- CRIK_Mmus_CRIK LEYQLENIQ----------VLYSHEK--VKMEGTISQQTKLI---DFLQAKMDQPAK-KK let-502_Cele_ROCK MALEQERDTM-SKRIAALFYENDKQAEH-----------FNIAIQ--------------- K08B12.5_Cele_GEK ASLMREVAML-KQQKNIE----------NSSDSA--FS---STM----GRG----DLM-- DMPK2_Hsap_GEK QALQQELAML-REELRAR------------GPVDTKPSNSLIPFLSFRSSE----K---- DMPK1_Hsap_GEK RDLEAHVRQL-QERMELL-----------QAEG--------------------------- CRIK_Hsap_CRIK LEYQLENIQ----------VLYSHEK--VKMEGTISQQTKLI---DFLQAKMDQPAK-KK ROCK1_Mmus_ROCK RKLQLELNQE-REKFNQMVVKHQKELND-----------MQAQLVEE--------CTH-- ROCK2_Mmus_ROCK RKLHMELKSE-REKLTQQMIKYQKELNE-----------MQAQIAEE--------SQI-- MRCK_Spur_GEK TELTDEVAKL-TTSVTEL----EQQLQELKQN-AADKAGSNLSF-AFLDNLDRYLDVD-- ROCK_Spur_ROCK RKLQQQLNQE-RDKYSQMVIKFTKEKEE-----------LTVQYTEE--------YSK-- CRIK_Spur_CRIK LESHMESQE----------VHHQHER--IKFDGTSAQQTKLI---DFLQAKVDAPPK-KK CC1G_07309_Ccin_GEK ------------------------------------------------------------ AqueK004_Aque_CRIK AEASKETEQALQDKAVIEEALE-LER--TRMQIQLAQFTKLI---DYRHNTP-SAAKKRS AqueK005_Aque_GEK ESLQKENEKL-NKENQ-----------KYRMGLGSRNDSFTTSIFH-------------- AqueK006_Aque_ROCK RKLRGELQQE-TQKYKRVVEKYQQQLEE-----------IQRQIQEE--------TQM-- ROCK2_Hsap_ROCK ----------------------------R--------------------IELQMTLDSKD ROCK1_Hsap_ROCK ----------------------------R--------------------NELQMQLASKE MRCKb_Hsap_GEK ----------------------------H--------------------DL---TFRTSS MRCKa_Hsap_GEK ----------------------------L--------------------DQFEDSFSSSS CG10522_Dmel_CRIK KTLADKLFGSSHTNKENVSPNDVESSILY--------------------RALKEELKREQ rok_Dmel_ROCK ----------------------------K--------------------QKMVMEIDCKA gek_Dmel_GEK ----------------------------S--------------------AFFRD--MSKN MRCKb_Mmus_GEK ----------------------------H--------------------DL---TFRTSS MRCKa_Mmus_GEK ----------------------------L--------------------DQFEDSLSSSS DMPK2_Mmus_GEK -------------------------------------------------DSAKD------ DMPK1_Mmus_GEK ------------------------------------------------------------ CRIK_Mmus_CRIK ----------------------------K---------------VPLQYNELKLALEKEK let-502_Cele_ROCK --------------------------------------------------DMQTTQDALR K08B12.5_Cele_GEK ----------------------------I--------------------SMN-NDYEMSN DMPK2_Hsap_GEK -------------------------------------------------DSAKD------ DMPK1_Hsap_GEK ------------------------------------------------------------ CRIK_Hsap_CRIK ----------------------------KGLFSRRKEDPALPTQVPLQYNELKLALEKEK ROCK1_Mmus_ROCK ----------------------------R--------------------NELQMQLASKE ROCK2_Mmus_ROCK ----------------------------R--------------------IELQMTLDSKD MRCK_Spur_GEK ----------------------------T--------------------KLNF-DFSDMD ROCK_Spur_ROCK ----------------------------H--------------------CELQLELDSRD CRIK_Spur_CRIK ----------------------------RG---------------RLQVKELQQKLDAEK CC1G_07309_Ccin_GEK ------------------------------------------------------------ AqueK004_Aque_CRIK -N-----------------------------------------------PKKGLKLSRKK AqueK005_Aque_GEK -------------------------------------------------------HQSGN AqueK006_Aque_ROCK ----------------------------R--------------------LELQHQLHTSE ROCK2_Hsap_ROCK SDIEQ--------------------LRS-------------------------------- ROCK1_Hsap_ROCK SDIEQ--------------------LRA-------------------------------- MRCKb_Hsap_GEK ASE----------------------QET------------------Q--APKP--EASP- MRCKa_Hsap_GEK SSLIDFL--------DDTDPV----ENT--------Y------VWNP--SVKFHIQSRS- CG10522_Dmel_CRIK KMNSL--------------------LKEQLAQLNGTAT-----LRSP--R-------KSA rok_Dmel_ROCK TEIEN--------------------LQS-------------------------------- gek_Dmel_GEK SEIIDSAESFGNESGDNFTPNFFQSGNS--------GMLFNYEPKYAGKNNKDHSSMKEA MRCKb_Mmus_GEK ASD----------------------QET------------------Q--ASKM--DLSP- MRCKa_Mmus_GEK SSLIDFL--------DDTDPV----DNT--------Y------IRNP--SIKFYIQSRP- DMPK2_Mmus_GEK -------------------P-----------------------------GNSGEGPRSG- DMPK1_Mmus_GEK ------------------------------------------------------------ CRIK_Mmus_CRIK ARCAE--------------------LEEALQKTRIELRSAREEAAH----RKATDHPHP- let-502_Cele_ROCK DELKE--------------------CKE-------------------------------- K08B12.5_Cele_GEK SSLMR--------------------Q--------------------E--MISRQ--STP- DMPK2_Hsap_GEK -------------------P-----------------------------GISGEATRHG- DMPK1_Hsap_GEK ------------------------------------------------------------ CRIK_Hsap_CRIK ARCAE--------------------LEEALQKTRIELRSAREEAAH----RKATDHPHP- ROCK1_Mmus_ROCK SDIEQ--------------------LRA-------------------------------- ROCK2_Mmus_ROCK SDIEQ--------------------LRS-------------------------------- MRCK_Spur_GEK PPE----------------------RDT------------------G----------AP- ROCK_Spur_ROCK SELEQ--------------------LQQ-------------------------------- CRIK_Spur_CRIK SRAWE--------------------LQKALNEARSDLQAAKLRGNC----PKSNEHPQP- CC1G_07309_Ccin_GEK ------------------------------------------------------------ AqueK004_Aque_CRIK RDPEK--------------------ERSEWMILK-------------------------- AqueK005_Aque_GEK --Q--------------------------------------------------------- AqueK006_Aque_ROCK GKLQQ--------------------LQQ-------------------------------- ROCK2_Hsap_ROCK ------------------------------------------------------------ ROCK1_Hsap_ROCK ------------------------------------------------------------ MRCKb_Hsap_GEK SMSVA-A-SEQQEDMARPP--QRPSAVPLPTTQ-----AL--------ALA-GP------ MRCKa_Hsap_GEK -TSPS-TSSE-AEPVKTVD--STPLSVHTPTLR-----KKGC---PGSTGF-PP------ CG10522_Dmel_CRIK AVNGDSDAPK-QRPVSIAALPRSPQKQQQPLKRTTSQVELKTTAEKPTKVT-IE------ rok_Dmel_ROCK ------------------------------------------------------------ gek_Dmel_GEK SVS-D-LSREESDQLVK----------------------------ESQKKV-PG------ MRCKb_Mmus_GEK SVSVA-TSTEQQEDMARPQ--QRPSPVPLPSTQ-----AL--------AMA-GP------ MRCKa_Mmus_GEK -TSPS-TASE-AEPVKIAD--CAPLPAHTPTLR-----KKGC---PASTGF-PP------ DMPK2_Mmus_GEK -AEAE-LRPEGRRSLRMGS--VFPR---VPAAT--------T---TPAEGP-PA------ DMPK1_Mmus_GEK -----------------------------------------A---AAITGV-PS------ CRIK_Mmus_CRIK S-TPA-TARQ---QIAMSAIVRSP--EHQPSAM-----SL--------LAP-PSSRR-KE let-502_Cele_ROCK ------------------------------------------------------------ K08B12.5_Cele_GEK SYENAILLHDHQVPKRVDD--LRYKQ--KPMKT-----ASGI---FSPVSI-SA------ DMPK2_Hsap_GEK -GEPD-LRPEGRRSLRMGA--VFPR---APTAN--------T---ASTEGL-PA------ DMPK1_Hsap_GEK -----------------------------------------A---TAVTGV-PS------ CRIK_Hsap_CRIK S-TPA-TARQ---QIAMSAIVRSP--EHQPSAM-----SL--------LAP-PSSRR-KE ROCK1_Mmus_ROCK ------------------------------------------------------------ ROCK2_Mmus_ROCK ------------------------------------------------------------ MRCK_Spur_GEK V-EP----------VATDD-----KSVHSSGTS-----SGE------TPPP-TP------ ROCK_Spur_ROCK ------------------------------------------------------------ CRIK_Spur_CRIK S-TPV-FTQT-ASANLISAIVQSP--GHRSSPS-----SL--------ILPTPGDKRNKA CC1G_07309_Ccin_GEK -----------------------------------------------SDN--PS------ AqueK004_Aque_CRIK ------------------------------------------------------------ AqueK005_Aque_GEK ---LE-TSTR-AAP-------Q------KPK----------------VITG-TE------ AqueK006_Aque_ROCK ------------------------------------------------------------ ROCK2_Hsap_ROCK ---------------------------------------QLQALHIG---LDS------- ROCK1_Hsap_ROCK ---------------------------------------KLLDLS------DS------- MRCKb_Hsap_GEK ----------------KP-KAHQFSIKSF---SSPTQCSHCTSLMVG---LIR----QGY MRCKa_Hsap_GEK ----------------KR-KTHQFFVKSF---TTPTKCHQCTSLMVG---LIR----QGC CG10522_Dmel_CRIK ----------------NQ-AHHRFELALQESKVDAVNCVVCEKA-VV---AGS----PFW rok_Dmel_ROCK ---------------------------------------KLNETA------SL------- gek_Dmel_GEK ----------------NT-AIHQFLVRTF---SSPTKCNHCTSLMVG---LTR----QGV MRCKb_Mmus_GEK ----------------KP-KAHQFSIKSF---PSPTQCSHCTSLMVG---LIR----QGY MRCKa_Mmus_GEK ----------------KR-KTHQFFVKSF---TAPTKCHQCTSLMVG---LIR----QGC DMPK2_Mmus_GEK ----------------KP-GSHTLRPRSF---PSPTKCLRCTSLMLG---LGR----QGL DMPK1_Mmus_GEK ----------------PR-ATD-------------------------------------- CRIK_Mmus_CRIK SSTPEEFSRRLKERMHHN-IPHRFNVGLN---MRATKCAVCLDT-VH---FGR----QAS let-502_Cele_ROCK ---------------------------------------ELANRNVNTRYEDK------- K08B12.5_Cele_GEK ----------------ME-RGHNFERMKI---KTPTKCGHCTSILIG---LDR----QGL DMPK2_Hsap_GEK ----------------KP-GSHTLRPRSF---PSPTKCLRCTSLMLG---LGR----QGL DMPK1_Hsap_GEK ----------------PR-ATD-------------------------------------- CRIK_Hsap_CRIK SSTPEEFSRRLKERMHHN-IPHRFNVGLN---MRATKCAVCLDT-VH---FGR----QAS ROCK1_Mmus_ROCK ---------------------------------------KLLDLS------DS------- ROCK2_Mmus_ROCK ---------------------------------------QLQALHIG---MDS------- MRCK_Spur_GEK ----------------KH-KTHKFMITNF---QVPAKCAHCTSLMLG---QSR----QGM ROCK_Spur_ROCK ---------------------------------------QIKNLTA----MHA------- CRIK_Spur_CRIK LATGKGTMKRLKERMKHN-IPHRFTIGLS---MRGTKCSACADT-IH---FGR----QVA CC1G_07309_Ccin_GEK ----------------QPTRTSRLPPLTL---APAMTNGRSNSRMLG---DSDSSETGGY AqueK004_Aque_CRIK ------------------------------------------------------------ AqueK005_Aque_GEK ----------------RE-GTHELVVRSF---DSPTKCDACTSVMFG---LVR----QGM AqueK006_Aque_ROCK ---------------------------------------GI-----------G------- ROCK2_Hsap_ROCK ------------------------SSIGS------------------------------- ROCK1_Hsap_ROCK ------------------------TSVAS------------------------------- MRCKb_Hsap_GEK ACEVCSFACHVSCKDGAPQVCPIPPEQSK------------------------------- MRCKa_Hsap_GEK SCEVCGFSCHITCVNKAPTTCPVPPEQTK------------------------------- CG10522_Dmel_CRIK KCKECKDVTHRKCRSNVQSHCGSTKPTA-------------------------------- rok_Dmel_ROCK ------------------------SSADN------------------------------- gek_Dmel_GEK VCEICGFACHTICCQKVPTTCPVPMDQTK------------------------------- MRCKb_Mmus_GEK ACEVCAFSCHVSCKDSAPQVCPIPPEQSK------------------------------- MRCKa_Mmus_GEK SCEVCGFSCHITCVNKAPTVCPVPPEQTK------------------------------- DMPK2_Mmus_GEK GCDTCGYFCHSACASQAP-PCPVPPELLR------------------------------- DMPK1_Mmus_GEK -----------------------PPSHLD------------------------------- CRIK_Mmus_CRIK KCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFC-RD--------------------- let-502_Cele_ROCK ------------------------RSLDS------------------------------- K08B12.5_Cele_GEK FCQSCQYACHVSCAERVSQSCPVPEEE-R------------------------------- DMPK2_Hsap_GEK GCDACGYFCHTTCAPQAP-PCPVPPDLLR------------------------------- DMPK1_Hsap_GEK -----------------------PPSHLD------------------------------- CRIK_Hsap_CRIK KCLECQVMCHPKCSTCLPATCGLPAEYATHFTEAFC-RD--------------------- ROCK1_Mmus_ROCK ------------------------TSVAS------------------------------- ROCK2_Mmus_ROCK ------------------------SSIGS------------------------------- MRCK_Spur_GEK MCEVCHFACHVACAEKAPSMCPISQQQMA------------------------------- ROCK_Spur_ROCK ------------------------SDSAS------------------------------- CRIK_Spur_CRIK KCIECHLICHPKCAHCLPHTCGLPFQFMRHFKQAMDGPSPSTRSVSSSSSTASSVVSSTA CC1G_07309_Ccin_GEK GYINYPYYSNSECSESEGPPSPSPS---P------------------------------- AqueK004_Aque_CRIK ------------------------------------------------------------ AqueK005_Aque_GEK MCKNCQMSCHVQCKDKVLATCPLPPGQAK------------------------------- AqueK006_Aque_ROCK ------------------------SYVSN------------------------------- ROCK2_Hsap_ROCK ---GP----GD------------------------------AEADD---GFPESRLEGWL ROCK1_Hsap_ROCK ---FP----SA------------------------------DETDG---NLPESRIEGWL MRCKb_Hsap_GEK ---RP----LG------------------------------VDVQR---G-IGTAYKGHV MRCKa_Hsap_GEK ---GP----LG------------------------------IDPQK---G-IGTAYEGHV CG10522_Dmel_CRIK ----P----SA------------------------------D------------------ rok_Dmel_ROCK ---DP----ED------------------------------SQHSSLLSLTQDSVFEGWL gek_Dmel_GEK ---RP----LG------------------------------IDPTR---G-IGTAYEGYV MRCKb_Mmus_GEK ---RP----LG------------------------------VDVQR---G-IGTAYKGYV MRCKa_Mmus_GEK ---GP----LG------------------------------IDPQK---G-VGTAYEGHV DMPK2_Mmus_GEK ---TA----LG------------------------------VHPET---G-TGTAYEGFL DMPK1_Mmus_GEK ---GPPAVAVG------------------------------QCPLV---G-PGPMHRRH- CRIK_Mmus_CRIK KMNSP----GL------------------------------QSKEP---G-SSLHLEGWM let-502_Cele_ROCK ---RE----GI------------------------------PSSLS----NQHIQMEGWL K08B12.5_Cele_GEK ---RP----LG------------------------------MI----------------- DMPK2_Hsap_GEK ---TA----LG------------------------------VHPET---G-TGTAYEGFL DMPK1_Hsap_GEK ---GPPAVAVG------------------------------QCPLV---G-PGPMHRRH- CRIK_Hsap_CRIK KMNSP----GL------------------------------QTKEP---S-SSLHLEGWM ROCK1_Mmus_ROCK ---FP----SA------------------------------DETDG---NLPESRIEGWL ROCK2_Mmus_ROCK ---GP----GD------------------------------AEPDD---GFPESRLEGWL MRCK_Spur_GEK ---KP----QG------------------------------IDPTR---G-IGTAYEGVL ROCK_Spur_ROCK ---IN----SA------------------------------GEAEN---G-QGGRLEGWL CRIK_Spur_CRIK SSLTS----FG------------------------------QEPM----V-CGNQIQGWM CC1G_07309_Ccin_GEK ---RP----GSAMSFISTSRRSGTPTVTMSTFSSRLRSASGS-------N-FNISGMGML AqueK004_Aque_CRIK ------------------------------------------------------------ AqueK005_Aque_GEK ---MP----SG------------------------------IDIHH---G-VGTACEGWI AqueK006_Aque_ROCK ---GP----ST------------------------------ETHDGAS--AIYQRETLLV ROCK2_Hsap_ROCK SLPVRNN-TKK-FGWVKKYVIVS--SKKILFYDSEQDKEQS-N--PYMVLDI-DKL--FH ROCK1_Hsap_ROCK SVPNRGN-IKR-YGWKKQYVVVS--SKKILFYNDEQDKEQS-N--PSMVLDI-DKL--FH MRCKb_Hsap_GEK KVPKPTG-V-K-KGWQRAYAVVC--DCKLFLYDLPEGKSTQPGVIASQVLDLRDDE--FS MRCKa_Hsap_GEK RIPKPAG-V-K-KGWQRALAIVC--DFKLFLYDIAEGKASQPSVVISQVIDMRDEE--FS CG10522_Dmel_CRIK --------------------------------------------------DL-SSI--QS rok_Dmel_ROCK SVPNKQN-RRRGHGWKRQYVIVS--SRKIIFYNSDIDKHNTTD--AVLILDL-SKV--YH gek_Dmel_GEK KVPKSGV-I-K-RGWIRQFVVVC--DFKLFLYDISPDRCALPSVSVSQVLDMRDPE--FS MRCKb_Mmus_GEK KVPKPTG-V-K-KGWQRAYAVVC--DCKLFLYDLPEGKSTQPGVVASQVLDLRDEE--FA MRCKa_Mmus_GEK RIPKPAG-V-K-KGWQRALAVVC--DFKLFLYDIAEGKASQPTSVISQVIDMRDEE--FS DMPK2_Mmus_GEK SVPRPSG-V-R-RGWQRVYAALS--DSRLLLFDAPDPRGSLASGVLLQALDLRDPQ--FS DMPK1_Mmus_GEK ------------------------------------------------------------ CRIK_Mmus_CRIK KVPRNNK-RGQ-QGWDRKYIVLE--GSKVLIYDNEAREAGQRPVE-EFELCLPDGD--VS let-502_Cele_ROCK SLRDNTKKSRK-PKWTNCFVALN--EYSFTIYVDEKA---V-S--VILLIEA-GAM--AH K08B12.5_Cele_GEK -------------------------------RHAEQNKMQDVKNEIRLVLDMRDPD--FT DMPK2_Hsap_GEK SVPRPSG-V-R-RGWQRVFAALS--DSRLLLFDAPDLRLSPPSGALLQVLDLRDPQ--FS DMPK1_Hsap_GEK ------------------------------------------------------------ CRIK_Hsap_CRIK KVPRNNK-RGQ-QGWDRKYIVLE--GSKVLIYDNEAREAGQRPVE-EFELCLPDGD--VS ROCK1_Mmus_ROCK SVPNRGN-IKR-YGWKKQYVVVS--SKKILFYNDEQDKEQS-S--PSMVLDI-DKL--FH ROCK2_Mmus_ROCK SLPVRNN-TKK-FGWVKKYVIVS--SKKILFYDSEQDKEQS-N--PYMVLDI-DKL--FH MRCK_Spur_GEK RIPKPGG-V-R-KGWMKQFVVVC--DFKLFLFDVLDGRASEPTNDISHILDMRDEE--FS ROCK_Spur_ROCK SLPGKNL-R-R-HGWKKHFVEVS--SKKILFYESEDQKAQK-K--PYLVLAI-DKL--FH CRIK_Spur_CRIK KTPRFSR-MNK-QGWEKKWCCLE--GTMLSLFDKENLDTGKQPTD-EYSLCPEDAI--VT CC1G_07309_Ccin_GEK GVPSPSL-GPG-GPWGRPWEHER------------------------------------- AqueK004_Aque_CRIK --------------------------------------------------DI-AKNSKDN AqueK005_Aque_GEK QVPKPGG-V-K-KGWTRAYAFVC--DFKIFCHEPSNDV-HSPANGVFNIFDIRDIN--FR AqueK006_Aque_ROCK QVPKGNN-ARK-NGWKDVFLVLSFTNKKLLIYDRPEDMGTDIP--PSFTLEL-SQV--YS ROCK2_Hsap_ROCK V-RPVTQTDVY--RADAKEIPRIFQILYAN----------------------EGESKK-E ROCK1_Hsap_ROCK V-RPVTQGDVY--RAETEEIPKIFQILYAN----------------------EGECRK-D MRCKb_Hsap_GEK V-SSVLASDVI--HATRRDIPCIFRVTASLLGAP------SKTSSLLILTENENEKRK-W MRCKa_Hsap_GEK V-SSVLASDVI--HASRKDIPCIFRVTASQLSAS------NNKCSILMLADTENEKNK-W CG10522_Dmel_CRIK V-SSLTLDSVDVAGGTTSGGEYIGSLV--------------------------------- rok_Dmel_ROCK V-RSVTQGDVI--RADAKEIPRIFQLLYAG----------------------EGASHR-P gek_Dmel_GEK V-GSVRESDVI--HAAKKDVPCIFKIKTALIDGG------L-SLNTLMLADNESEKSK-W MRCKb_Mmus_GEK V-SSVLASDVI--HATRRDIPCIFRVTASLLGSP------SKTSSLLILTENENEKRK-W MRCKa_Mmus_GEK V-SSVLASDVI--HASRKDIPCIFRVTASQLSAP------SNKCSILMLADSENERSK-W DMPK2_Mmus_GEK A-TPVLAPDVI--HAQSKDLPRIFRVTASQLTVP------PTTCTVLLLAENEGERER-W DMPK1_Mmus_GEK ------------------------------------------------------------ CRIK_Mmus_CRIK IHGAVGASELA--NTAKADVPYILKMESHPHTTC------WPGRTLYLLAPSFPDKQR-W let-502_Cele_ROCK V-RHVTAADLR--NVDDSQLPKIFHIMYDD----------------------ASCNSSRH K08B12.5_Cele_GEK V-CGVSEADVI--HAQKGDIPKIFRVTTTQILNSSSEYSSSSKFYTLFMAETEEEKRK-W DMPK2_Hsap_GEK A-TPVLASDVI--HAQSRDLPRIFRVTTSQLAVP------PTTCTVLLLAESEGERER-W DMPK1_Hsap_GEK ------------------------------------------------------------ CRIK_Hsap_CRIK IHGAVGASELA--NTAKADVPYILKMESHPHTTC------WPGRTLYLLAPSFPDKQR-W ROCK1_Mmus_ROCK V-RPVTQGDVY--RAETEEIPKIFQILYAN----------------------EGECRK-D ROCK2_Mmus_ROCK V-RPVTQTDVY--RADAKEIPRIFQILYAN----------------------EGESKK-E MRCK_Spur_GEK V-SSVLASDVI--HAPSKDVPCIFKVSVSQLNPP------GLCAQLLLLADSEAEKRK-W ROCK_Spur_ROCK V-RAVTQGDVI--RAEARDIPRIFQLLYAG----------------------EGENRR-M CRIK_Spur_CRIK VHAGVSATELP--NTASSDLPFVFHLESRPVTTCW-----PDTKTLYLMAPSFQDKQQ-W CC1G_07309_Ccin_GEK ------------------------------------------------------------ AqueK004_Aque_CRIK K-ASLGFD---TIDTTSIKLLTVFMIL--------------------------------- AqueK005_Aque_GEK V-SKVTRQDVI--HAGEKLIPTIFKISCTHPTCSSV----GILSELLIRTDNENERDK-W AqueK006_Aque_ROCK V-RSLTQGEHERVRIKPNDSKRVLQVAYVD----------------------QQSEQS-I ROCK2_Hsap_ROCK QEF--------------------------------------------------------- ROCK1_Hsap_ROCK VEM--------------------------------------------------------- MRCKb_Hsap_GEK VGILEGLQSILHKNRLRNQVVHVPLEAYD-SSLPLI-----KAILTAAIVDADRIAVG-L MRCKa_Hsap_GEK VGVLSELHKILKKNKFRDRSVYVPKEAYD-STLPLI-----KTTQAAAIIDHERIALG-N CG10522_Dmel_CRIK ---------------------YSSDGAED-QARKEI-----EVNCAFEVAEQQILLLG-C rok_Dmel_ROCK DEQ--------------------------------------------------------- gek_Dmel_GEK VIALGELHRILKRNSLPNTAIFKVNEILD-NTLSLI-----RNALCSVIIYPNQILLG-T MRCKb_Mmus_GEK VGILEGLQAILHKNRLKSQVVHVAQEAYD-SSLPLI-----KAVLAAAIVDGDRIAVG-L MRCKa_Mmus_GEK VGVLSELHKILKKNKFRDRSVYVPKEAYD-STLPLI-----KTTQAAAIIDHERIALG-N DMPK2_Mmus_GEK LQVLGELQRLLLDARPRPRPVYTLKEAYD-NGLPLL-----PHALCAAVIDQERLALG-T DMPK1_Mmus_GEK ------------------------------------------------------------ CRIK_Mmus_CRIK VTALESVVAGGRVSR---EKAEADAKLLGN-SLLKLEGDDRLDMNCTLPFSDQVVLVG-T let-502_Cele_ROCK ASN--------------------------------------------------------- K08B12.5_Cele_GEK VVALSELKTLLRRSKLADRKAFLVKEVFDVTTLPSI-----RVAQCCAIIDRSKIVIGFS DMPK2_Hsap_GEK LQVLGELQRLLLDARPRPRPVYTLKEAYD-NGLPLL-----PHTLCAAILDQDRLALG-T DMPK1_Hsap_GEK ------------------------------------------------------------ CRIK_Hsap_CRIK VTALESVVAGGRVSR---EKAEADAKLLGN-SLLKLEGDDRLDMNCTLPFSDQVVLVG-T ROCK1_Mmus_ROCK IEV--------------------------------------------------------- ROCK2_Mmus_ROCK PEF--------------------------------------------------------- MRCK_Spur_GEK VDALNNLQRHLKHNQLPDRTVFRAQEVFD-SSMPLV-----KVTHCADIVDASRFVIG-T ROCK_Spur_ROCK VPD--------------------------------------------------------- CRIK_Spur_CRIK MVGLEVASIRGRNAG-PGGSVRDQARLIGN-TLLKLNQENRLDINCTLLISDNVLLIG-A CC1G_07309_Ccin_GEK ------------------------------------------------------------ AqueK004_Aque_CRIK ------------------------------------------------------------ AqueK005_Aque_GEK VATLDELQKAARQLATKKNPVISCHGLYSSQQLQLL-----KSVQSAAIANNDRILLG-A AqueK006_Aque_ROCK IAH--------------------------------------------------------- ROCK2_Hsap_ROCK -----------------------------------PV-EPVG------------------ ROCK1_Hsap_ROCK -----------------------------------EP-VQQA------------------ MRCKb_Hsap_GEK EEGLYVIEVT--RDVIVRAAD--CKK-----VHQIEL-APREKIVILLCG--RNHHVHLY MRCKa_Hsap_GEK EEGLFVVHVT--KDEIIRVGD--NKK-----IHQIEL-IPNDQLVAVISG--RNRHVRLF CG10522_Dmel_CRIK NTGLYAYHLD--SQRLVHISG--LES-----VSCMSI-CKRLAKAIMVGTVG--EKLYQC rok_Dmel_ROCK -----------------------------------SQL-DVS----VLHG--NC------ gek_Dmel_GEK EDGLFYINLD--QYEIARIGE--SKK-----ILQLWY-IEEEQILVILCG--KQRNLRLL MRCKb_Mmus_GEK EEGLYVIELT--RDVIVRAAD--CKK-----VYQIEL-APKEKIAILLCG--RNHHVHLY MRCKa_Mmus_GEK EEGLFVVHVT--KDEIVRVGD--NKK-----IHQIEL-IPSDQLVAVISG--RNRHVRLF DMPK2_Mmus_GEK EEGLFVIHLH--SNDIFQVGD--CRR-----VQRLAV-SSAAGLLAVLCG--RGPSVRLF DMPK1_Mmus_GEK ------------------------------------------------------------ CRIK_Mmus_CRIK EEGLYALNVL--KNSLTHIPG--IGA-----VFQIYI-IKDLEKLLMIAG--EERALCLV let-502_Cele_ROCK -----------------------------------SDL-SMI------------------ K08B12.5_Cele_GEK DHGLYCIEIS--RQLLIPVGG--EKENKQRCVETVEY-DEAEQLLMMIVGPAKDRHVRIV DMPK2_Hsap_GEK EEGLFVIHLR--SNDIFQVGE--CRR-----VQQLTL-SPSAGLLVVLCG--RGPSVRLF DMPK1_Hsap_GEK ------------------------------------------------------------ CRIK_Hsap_CRIK EEGLYALNVL--KNSLTHVPG--IGA-----VFQIYI-IKDLEKLLMIAG--EERALCLV ROCK1_Mmus_ROCK -----------------------------------EP-VQQG------------------ ROCK2_Mmus_ROCK -----------------------------------PV-EPVG------------------ MRCK_Spur_GEK EDGLYTVEIS--SGFIVRV-D--RKQ-----IHQVRV-LKDEQLVIVISG--RGRHLRLF ROCK_Spur_ROCK -----------------------------------EANENPG------------------ CRIK_Spur_CRIK EEGLYTMLLMDRKKPLSQIGG--VSS-----VFQMHI-ITQLMMLLIFAG--PERNLCIV CC1G_07309_Ccin_GEK ------------------------------------------------------------ AqueK004_Aque_CRIK ------------------------------------------------------------ AqueK005_Aque_GEK EDGLYMFDVA--DEGLYQCGDKDLKR-----VIQLAV-LQDEELVVILAG--RRPTLRLL AqueK006_Aque_ROCK -----------------------------------PP-V--------------------- ROCK2_Hsap_ROCK --------EKSN----------------------Y-----ICHKGHEFIPT--LYHFPT- ROCK1_Hsap_ROCK --------EKTN----------------------F-----QNHKGHEFIPT--LYHFPA- MRCKb_Hsap_GEK PWSSLDGAEGSF-----------------------DIK-LPETKGCQLMATATLKRNSG- MRCKa_Hsap_GEK PMSALDGRETDF------------------------YK-LSETKGCQTVTSGKVRHGAL- CG10522_Dmel_CRIK DYRQLESRCQSS-------SSCHKPVLETSAIELPFANRTPSEKWKLVLISDEAENA--L rok_Dmel_ROCK -----N-EERPG----------------------T-----IVHKGHEFVHI--TYHMPT- gek_Dmel_GEK PIRALEASDVEW------------------------IK-VVESKNCISACTGIIRRFPNI MRCKb_Mmus_GEK PWSSFDGAEASN----------------------FDIK-LPETKGCQLIATGTLRKSSS- MRCKa_Mmus_GEK PMSALDGRETDF------------------------YK-LAETKGCQTIAAGKVRHGAL- DMPK2_Mmus_GEK ALDELESAEVAG------------------------AK-IPESRGCQALVAGRILQART- DMPK1_Mmus_GEK ------------------------------------------------------------ CRIK_Mmus_CRIK DVKKVKQSLAQSHLPAQPDV--------------SPNI-FEAVKGCHLFAAGKIENS--L let-502_Cele_ROCK --------ESFR----------------------E-----ESWKRHDFQEL--SYHIRT- K08B12.5_Cele_GEK PSAALDGRDLKW------------------------IK-VNDTKGCHLLAVGTNNPGGR- DMPK2_Hsap_GEK ALAELENIEVAG------------------------AK-IPESRGCQVLAAGSILQART- DMPK1_Hsap_GEK ------------------------------------------------------------ CRIK_Hsap_CRIK DVKKVKQSLAQSHLPAQPDI--------------SPNI-FEAVKGCHLFGAGKIENG--L ROCK1_Mmus_ROCK --------EKTN----------------------F-----QNHKGHEFIPT--LYHFPA- ROCK2_Mmus_ROCK --------EKSN----------------------Y-----ICHKGHEFIPT--LYHFPT- MRCK_Spur_GEK PIACLDGE-ATV------------------------IK-VEEPRGCTMFTTGIIRQGST- ROCK_Spur_ROCK -----Q-DDEEG----------------------T-----IVHKNHKFTVV--HFHMPT- CRIK_Spur_CRIK DLKHLRTMSSQAQMPAPGLF--------------SPSI-FYLIQSCHLFACGKVDGS--F CC1G_07309_Ccin_GEK ------------------------------------------------------------ AqueK004_Aque_CRIK ------------------------------------------------------------ AqueK005_Aque_GEK PTSALDSGEMRN----------------------VVID-VTETKGAHLFCTGNLGPT--- AqueK006_Aque_ROCK -----E-----G----------------------E-----VHVRGHHFVES--RNSSRS- ROCK2_Hsap_ROCK -N--CEACMK------PLWHMFK------------------------------------- ROCK1_Hsap_ROCK -N--CDACAK------PLWHVFK------------------------------------- MRCKb_Hsap_GEK -TCLFVAVKR-----LILCYEIQRTK-PFHRKFNEIVAPGSVQCLAVLRD-RLCVGYPSG MRCKa_Hsap_GEK -TCLCVAMKR-----QVLCYELFQSK-TRHRKFKEIQVPYNVQWMAIFSE-QLCVGFQSG CG10522_Dmel_CRIK DSVAIAATST-----RIVILKYDLKLH-MFKPVRALDTATPVTSIFF-TRHSAIV-SSDK rok_Dmel_ROCK -A--CEVCPK------PLWHMFK------------------------------------- gek_Dmel_GEK VYSFIIALKRPNNHTQIVVYEINRTR-TRHQKTCEFTIGYMAQHLQILSDMRLVVAHQSG MRCKb_Mmus_GEK -TCLFVAVKR-----LILCYEIQRTK-PFHRKFSELVAPGHVQWMAVFKD-RLCVGYPSG MRCKa_Mmus_GEK -SCLCVAMKR-----QVLCYELFQSK-TRHRKFKEIQVPCNVQWMAIFSE-HLCVGFQSG DMPK2_Mmus_GEK -PVLCVAVKR-----QVLCYQLGPGPGPWQRRIRELQAPAPVQSLGLLGD-RLCVGAAGT DMPK1_Mmus_GEK -----------------------------------LLLPARIPR---------------- CRIK_Mmus_CRIK --CICAAMPS-----KVVILRYNDNLS-KYCIRKEIETSEPCSCIHFTNY-SILIGTN-K let-502_Cele_ROCK -F--CDVCNK------KLSDIIR------------------------------------- K08B12.5_Cele_GEK AGFFAVAFKK-----SVTIFQIDRSE-KRHKKWKDLAMPGTPQSIAIFNG-RLYVGFSHS DMPK2_Hsap_GEK -PVLCVAVKR-----QVLCYQLGPGPGPWQRRIRELQAPATVQSLGLLGD-RLCVGAAGG DMPK1_Hsap_GEK -----------------------------------LLLPARVPR---------------- CRIK_Hsap_CRIK --CICAAMPS-----KVVILRYNENLS-KYCIRKEIETSEPCSCIHFTNY-SILIGTN-K ROCK1_Mmus_ROCK -N--CEACAK------PLWHVFK------------------------------------- ROCK2_Mmus_ROCK -N--CEACMK------PLWHMFK------------------------------------- MRCK_Spur_GEK -TCMCVAMKR-----TVLIYEFNRNK-GRHKRIKEVTLPAPAQCMEVFGG-RLCAGYTSG ROCK_Spur_ROCK -T--CECCSK------TLSHLVR------------------------------------- CRIK_Spur_CRIK --YLCAAMPT-----KISILKYSEGLS-KFCVRKEIQTAEPSSCLLFTEA-SILAGTD-R CC1G_07309_Ccin_GEK ------------------------------------------------------------ AqueK004_Aque_CRIK ------------------------------------------------------------ AqueK005_Aque_GEK -QYICVAIKN-----KVLIYELSRTK-TRYERKKELVISGQVHSMSMVNE-KLCIGYLSG AqueK006_Aque_ROCK -S--CDVCGK------TLPLALL------------------------------------- ROCK2_Hsap_ROCK ------------------------------------------------------------ ROCK1_Hsap_ROCK ------------------------------------------------------------ MRCKb_Hsap_GEK FCLLSIQG-DGQPL-------------NLVNPND-PSLAFL----SQQS-FDALCAVEL- MRCKa_Hsap_GEK FLRYPLNG-EGNPY-------------SMLHSND-HTLSFI----AHQP-MDAICAVEI- CG10522_Dmel_CRIK FYEIDLDNY-AA--------------EEFVDLSD-KSMES------TAK-CQPLTAVRI- rok_Dmel_ROCK ------------------------------------------------------------ gek_Dmel_GEK FTAYFLRG-EATAM-------------SLVHPEN-QLCAFL----NYSG-VDAVRVIEIL MRCKb_Mmus_GEK FSLLSIQG-DGPPL-------------DLVNPTD-PSLAFL----SQQS-FDALCAVEL- MRCKa_Mmus_GEK FLRYPLNG-EGGPC-------------NMLHSND-HTLSFI----SHQP-MDALCAVEI- DMPK2_Mmus_GEK FALYPLLN-EAAPL-------------ALGTGLVAEELPAS----RGGL-GEALGAVEL- DMPK1_Mmus_GEK ------------------------------------------------------------ CRIK_Mmus_CRIK FYEIDMKQY---T------------LDEFLDKND-HSLAPAVF-ASSSNS-FPVSIVQAN let-502_Cele_ROCK ------------------------------------------------------------ K08B12.5_Cele_GEK FRSWSLVGVDSSPVGSGDASGAVLQHISLVNMED-TSLQFL----NQQTSYEAKLIVNV- DMPK2_Hsap_GEK FALYPLLN-EAAPL-------------ALGAGLVPEELPPS----RGGL-GEALGAVEL- DMPK1_Hsap_GEK ------------------------------------------------------------ CRIK_Hsap_CRIK FYEIDMKQY---T------------LEEFLDKND-HSLAPAVF-AASSNS-FPVSIVQVN ROCK1_Mmus_ROCK ------------------------------------------------------------ ROCK2_Mmus_ROCK ------------------------------------------------------------ MRCK_Spur_GEK FGLFSIQM-QGQHV------------EPLLNIDD-PSLRFL----IEIP-TEALAAVQI- ROCK_Spur_ROCK ------------------------------------------------------------ CRIK_Spur_CRIK FYEIELKDF---K------------IDEFLESTD-TSLAFAVYGASQLDS-FPIAAIQVA CC1G_07309_Ccin_GEK ------------------------------------------------------------ AqueK004_Aque_CRIK ------------------------------------------------------------ AqueK005_Aque_GEK FSVFNVYL-DQPEI----------SQYXLVNNDD-LSLGFV----RINE-LNAMCAVEIN AqueK006_Aque_ROCK ------------------------------------------------------------ ROCK2_Hsap_ROCK -------------------------------------PPPALECRRCHIKCH-------- ROCK1_Hsap_ROCK -------------------------------------PPPALECRRCHVKCH-------- MRCKb_Hsap_GEK -----ESEEYLLCFSHMGLYVDPQGRRARAQELMWPAAPVACSCSPTHVTVYSEYGVDVF MRCKa_Hsap_GEK -----SSKEYLLCFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENAVDIF CG10522_Dmel_CRIK -----SRQEYLLCFAEYGVFVDEFGCRSRPYDLNWVYAPTGFVYRDPFLFISHYQSVQIV rok_Dmel_ROCK -------------------------------------PPAAYECKRCRNKIH-------- gek_Dmel_GEK CPSGGNFGEYLLVFQTLAIYVDLQGRKSRDREIMYPAFPTYITFCDGHLLVFSDTHLDIF MRCKb_Mmus_GEK -----KSEEYLLCFSHMGLYVDPQGRRSRMQELMWPAAPVACSCSPTHVTVYSEYGVDVF MRCKa_Mmus_GEK -----SNKEYLLCFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENAVDIF DMPK2_Mmus_GEK -----SLSELLLLFATAGVYVDSAGRKSRSHELLWPAAPTGWGYTAPYLTVFSENALDVF DMPK1_Mmus_GEK ------------------------------------------------------------ CRIK_Mmus_CRIK --SAGQREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVI let-502_Cele_ROCK -------------------------------------PTPAFECKNCHFKTH-------- K08B12.5_Cele_GEK ---PGSPDEYLLVFNMIGLYVNEMGRRSRLPEVMFPTQAKYFAYHEPYLCVFSENEVDIF DMPK2_Hsap_GEK -----SLSEFLLLFTTAGIYVDGAGRKSRGHELLWPAAPMGWGYAAPYLTVFSENSIDVF DMPK1_Hsap_GEK ------------------------------------------------------------ CRIK_Hsap_CRIK --SAGQREEYLLCFHEFGVFVDSYGRRSRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVI ROCK1_Mmus_ROCK -------------------------------------PPPALECRRCHVKCH-------- ROCK2_Mmus_ROCK -------------------------------------PPPALECRRCHIKCH-------- MRCK_Spur_GEK -----SEREYLLCFSTLGVYVDYQGRRTREQELMWPSHPTEIAFNSPYLIVYSDISVDIY ROCK_Spur_ROCK -------------------------------------PPPALECKLCRLKVH-------- CRIK_Spur_CRIK --PDGEPQEFLLCFHEFGIFVDSKGRRSRPDDMKWSRLPLAFTYRQPYLYMAHFNSVEVC CC1G_07309_Ccin_GEK ------DRDRDRESGGIGIGIGKVEERDREKERTFMAMPRKVSAPPV-----------ID AqueK004_Aque_CRIK ----------------------------RVMHVMWWTIHVM-------------WWWSSW AqueK005_Aque_GEK -----NGQEYLLCFHLVGIYVTNEGRRSRKQELLWHSTPTSIVHRQPYLLVFCESNLEVY AqueK006_Aque_ROCK -------------------------------------SGGILECKHCQMKCH-------- ROCK2_Hsap_ROCK -------------------------------------------------KDHMDKKE--- ROCK1_Hsap_ROCK -------------------------------------------------RDHLDKKE--- MRCKb_Hsap_GEK DVRTMEWVQ--------TIGLRRIRPLNSEGTLNLLNCE---PPRLIYFKSKFS-GA--- MRCKa_Hsap_GEK DVNSMEWIQ--------TLPLKKVRPLNNEGSLNLLGLE---TIRLIYFKNKMAEGD--- CG10522_Dmel_CRIK RLHRSFS-------------------------------------------KEMASGD--- rok_Dmel_ROCK -------------------------------------------------KEHVDKH---- gek_Dmel_GEK NTQTAEWVQ--------SIGLKQSLPLNNLGNVVLSSVN--DTPLIVYLSNIHT-KG--- MRCKb_Mmus_GEK DVRTMEWVQ--------TIGLRRIRPLNSDGSLNLLGCE---PPRLIYFKNKFS-GT--- MRCKa_Mmus_GEK DVNSMEWIQ--------TLPLKKVRPLNTEGSLNLLGLE---TIRLIYFKNKMAEGD--- DMPK2_Mmus_GEK DVRRAEWVQ--------TVPLKKVRPLNPEGSLFLYGTE---KVRLTYLRNPLAEKD--- DMPK1_Mmus_GEK ------------------------------------------------------------ CRIK_Mmus_CRIK EIQARSSLGSPARAYLEIPNPRYLGPAISSGAIYLASSY-QDKLRVICCKGNLVKESGTE let-502_Cele_ROCK -------------------------------------------------KDHVAQG---- K08B12.5_Cele_GEK NVTLAEWVQ--------TINLRSAKPLSGDGILSTCLCN--DSPIFVLLQNVLQDQD--- DMPK2_Hsap_GEK DVRRAEWVQ--------TVPLKKVRPLNPEGSLFLYGTE---KVRLTYLRNQLAEKD--- DMPK1_Hsap_GEK ------------------------------------------------------------ CRIK_Hsap_CRIK EIQARSSAGTPARAYLDIPNPRYLGPAISSGAIYLASSY-QDKLRVICCKGNLVKESGTE ROCK1_Mmus_ROCK -------------------------------------------------RDHLDKKE--- ROCK2_Mmus_ROCK -------------------------------------------------KDHMDKKE--- MRCK_Spur_GEK DIGIMEWVQ--------TIPIKGTRQLSWDGSLNLSFVTDLHAPRLVYFHNRLAVSD-HE ROCK_Spur_ROCK -------------------------------------------------KEHYDKQE--- CRIK_Spur_CRIK EIKHTAETPSRERTFLSQANPRFVGPAITPGAVYIASLG-DRSVELMCLQGNYASGGSSE CC1G_07309_Ccin_GEK DVQPVEEVE-----F----------------------------PRN-------------- AqueK004_Aque_CRIK TI---------------------------------------------------------- AqueK005_Aque_GEK NVETSEWTQ--------TISIKKLQSISPGGTIALCNSS--DSTCTVYIKSDSD-SS-SN AqueK006_Aque_ROCK -------------------------------------------------KDDVDKT---- ROCK2_Hsap_ROCK EIIAPCK-V------YYDI-STAKNLLLLANS-TEEQ-Q-KWVSRLVK----KIPKKPPA ROCK1_Hsap_ROCK DLICPCK-V------SYDV-TSARDMLLLACS-QDEQ-K-KWVTHLVK----KIPKNPPS MRCKb_Hsap_GEK VLNVPDT-SDNSKKQMLRT-RSKRRFVFK-VP-EEER-LQQRREMLRDPE--LRSKMISN MRCKa_Hsap_GEK ELVVPET-SDNSRKQMVRNINNKRRYSFR-VP-EEER-MQQRREMLRDPE--MRNKLISN CG10522_Dmel_CRIK -----N-ASENSESP-------------------ELQ-------RVYLPH--YMSTLLAN rok_Dmel_ROCK DPLAPCK-L------NHDP-RSARDMLLLAAT-PEDQ-S-LWVARLLK----RIQKSGYK gek_Dmel_GEK LL---QY-RDGNRKGL---PSIKRRFSIR-EI-NKTI-KSD-----------RRSKMISA MRCKb_Mmus_GEK ILNVPDT-SDNSKKQMLRT-RSKRRFVFK-VP-EEER-LQQRREMLRDPE--LRSKMISN MRCKa_Mmus_GEK ELVVPET-SDNSRKQMVRNINNKRRYSFR-VP-EEER-MQQRREMLRDPE--MRNKLISN DMPK2_Mmus_GEK EFDIPDL-TDNSRRQLFRT-KSKRRFFFR-VS-DELR-QQQRREMLKDPF--VRSKFISP DMPK1_Mmus_GEK ----------------PGL-SEARCLLLFAAA-LA------------------------- CRIK_Mmus_CRIK QHRVPS-TSRSSPNK------------------------------------------RGP let-502_Cele_ROCK -SLPMCR---------YNT-GLSRELVLMAPQ-TDNC-N-KWVSQLRR----FIESSRSA K08B12.5_Cele_GEK SIEVPVNLASGSTDG--R-KVTRRKFTFR-TIGKDDRSASERR----------SHIQIST DMPK2_Hsap_GEK EFDIPDL-TDNSRRQLFRT-KSKRRFFFR-VS-EEQQ-KQQRREMLKDPF--VRSKLISP DMPK1_Hsap_GEK ----------------PGL-SEALSLLLFAVV-LS------------------------- CRIK_Hsap_CRIK HHRGPS-TSRSSPNK------------------------------------------RGP ROCK1_Mmus_ROCK DLISPCK-V------SYDV-TSARDMLLLACS-QDEQ-K-KWVTHLVK----KIPKNPPS ROCK2_Mmus_ROCK EIIAPCK-V------YYDI-SSAKNLLLLANS-TEEQ-Q-KWVSRLVK----KIPKKPPA MRCK_Spur_GEK KLNIQTV-VKSSKQQ-----ANKRKFSFK-SK-DEIR----------------KNVIISA ROCK_Spur_ROCK EFCPPCK-V------NIDA-ETAKHMLLMANS-KEEQ-Q-RWIGKLGK----QIQDKRVS CRIK_Spur_CRIK QLRVPA-HFDSPPPK------------------------------------------RIP CC1G_07309_Ccin_GEK -------------------ATTKPRIASA-IP-PNK-------PLLSNSSLRRTSVATST AqueK004_Aque_CRIK ------------------------------------------------------------ AqueK005_Aque_GEK ---ILH-VTSVNRRGTVIT-KSKK-----------V-V-KP------------ARPVISG AqueK006_Aque_ROCK DLIRPCV-A------G--E-QDQKKLLLLIKS-DDDR-S-RWLSMLQAGE--VVPSNKSP ROCK2_Hsap_ROCK PDPFAR---------------------------------------SSPRT-SMKIQ---- ROCK1_Hsap_ROCK --GFVR---------------------------------------ASPRTLSTRST---- MRCKb_Hsap_GEK PTNFNHVA---HMGPGDGMQVLM--DLPLSAVPPSQEERPG----PAPTNLARQPPSRNK MRCKa_Hsap_GEK PTNFNHIA---HMGPGDGIQILK--DLPMNPRP--QESRTVF---SGSVSIPSITKSRPE CG10522_Dmel_CRIK SGDVNLYAVAIDQRPCNGTQKIY--HLDTMQA---------------------------- rok_Dmel_ROCK AASYNNN----------------------------STDGSK----ISPSQ-STRSS---- gek_Dmel_GEK PTNFNHIS---HMGPGDGIQNQRLLDLPTTL--ETADQACS----PIIHSLSCIPQSRKS MRCKb_Mmus_GEK PTNFNHVA---HMGPGDGMQVLM--DLPLSAAPTVQEEKQG----PTPAGLPRQPPSRSK MRCKa_Mmus_GEK PTNFNHIA---HMGPGDGIQILK--DLPMNPRP--QESRTVF---SGSVSIPSITKSRPE DMPK2_Mmus_GEK PTNFNHLV---HVGPTEGRPNTR--DGTRA-----QEQKSR----GARSSGPQRPHSFS- DMPK1_Mmus_GEK ------------------------------------------------------------ CRIK_Mmus_CRIK PTYNEHIT---KR-------------VASSPAP--PEGP------SHPRE-------PST let-502_Cele_ROCK AVSVSR-------------------------------------------VS-S------- K08B12.5_Cele_GEK PSDFMHIV---HMGPAPVMELQQ--NFID------------------------------- DMPK2_Hsap_GEK PTNFNHLV---HVGPANGRPGAR--DKSPA-----PEEKGR----VARGSGPQRPHSFS- DMPK1_Hsap_GEK ------------------------------------------------------------ CRIK_Hsap_CRIK PTYNEHIT---KR-------------VASSPAP--PEGP------SHPRE-------PST ROCK1_Mmus_ROCK --GFVR---------------------------------------ASPRTLSTRST---- ROCK2_Mmus_ROCK PDPFAR---------------------------------------SSPRT-SMKIQ---- MRCK_Spur_GEK PSNFSHIT---HMGPGDSLSKLQ--DIPGAESKPVRIKSMVGQPLPAQRSVTRQ-----R ROCK_Spur_ROCK ----------------------------------------------LPRTS--------- CRIK_Spur_CRIK RGYDPLLT---DR-------------TKKNTSP--PQGQ------QHPED-------TSG CC1G_07309_Ccin_GEK PSVHEHCS---HSSGSRTHERRR--A---------------------------------- AqueK004_Aque_CRIK ------------------------------------------------------------ AqueK005_Aque_GEK PTEFAYVQ---HFGPHPQLDVETMQ--NAG---EV--ARLRG------ASIPTLSMSQST AqueK006_Aque_ROCK SASSNSLV---PAGVNTKRDRTN--SLRFNKRP-TSAQHGR----GSPSGSSNRTYSVS- ROCK2_Hsap_ROCK ------------------------------------------------------------ ROCK1_Hsap_ROCK ------------------------------------------------------------ MRCKb_Hsap_GEK P--------------------YI-SWPSSGGSE--------------------------- MRCKa_Hsap_GEK PGRSMSASSGLSARSSAQNGSAL-KREFSGGSY--------------------------- CG10522_Dmel_CRIK ------------------------------------------------------------ rok_Dmel_ROCK ---------------------Y---K---------------------------------- gek_Dmel_GEK N--------------------FL------------------------------------- MRCKb_Mmus_GEK P--------------------YV-SWPSSGGSE--------------------------- MRCKa_Mmus_GEK PGRSMSASSGLSARSSAQNGSAL-KREFSGGSY--------------------------- DMPK2_Mmus_GEK --------------------EAF-RRPVSTGSDG-LPG---------------------- DMPK1_Mmus_GEK -------------------------AAATLGCTG-LVA---------------------- CRIK_Mmus_CRIK PHRYRDREGRTELRRDKSPGRPL-EREKSPGRML-------------------------- let-502_Cele_ROCK ---------------------R---R---------------------------------- K08B12.5_Cele_GEK ------------------------------------------------------------ DMPK2_Hsap_GEK --------------------EAL-RRPASMGSEG-LGG---------------------- DMPK1_Hsap_GEK -------------------------RAAALGCIG-LVA---------------------- CRIK_Hsap_CRIK PHRYR--EGRTELRRDKSPGRPL-EREKSPGRML-------------------------- ROCK1_Mmus_ROCK ------------------------------------------------------------ ROCK2_Mmus_ROCK ------------------------------------------------------------ MRCK_Spur_GEK PNTVIN----LS-RDSDQNGQ-L-SLAPSGAAN--------------------------- ROCK_Spur_ROCK ------------------------------------------------------------ CRIK_Spur_CRIK KVRKREREREREKKRERDRGRER-RREREGGREI-------------------------- CC1G_07309_Ccin_GEK ------------------------------------------------------------ AqueK004_Aque_CRIK ------------------------------------------------------------ AqueK005_Aque_GEK --------QSLSPRKDHHHSQILSSHHYKAGSIEHLPAAYQSIEYKNIIVNIQFPPEYPA AqueK006_Aque_ROCK --------------------TQ---R---------------------------------- ROCK2_Hsap_ROCK ------------------------------------------------------------ ROCK1_Hsap_ROCK ------------------------------------------------------------ MRCKb_Hsap_GEK ------------------------------------------------------------ MRCKa_Hsap_GEK ------------------------------------------------------------ CG10522_Dmel_CRIK ------------------------------------------------------------ rok_Dmel_ROCK ------------------------------------------------------------ gek_Dmel_GEK ------------------------------------------------------------ MRCKb_Mmus_GEK ------------------------------------------------------------ MRCKa_Mmus_GEK ------------------------------------------------------------ DMPK2_Mmus_GEK ------------------------------------------------------------ DMPK1_Mmus_GEK ------------------------------------------------------------ CRIK_Mmus_CRIK ------------------------------------------------------------ let-502_Cele_ROCK ------------------------------------------------------------ K08B12.5_Cele_GEK ------------------------------------------------------------ DMPK2_Hsap_GEK ------------------------------------------------------------ DMPK1_Hsap_GEK ------------------------------------------------------------ CRIK_Hsap_CRIK ------------------------------------------------------------ ROCK1_Mmus_ROCK ------------------------------------------------------------ ROCK2_Mmus_ROCK ------------------------------------------------------------ MRCK_Spur_GEK ------------------------------------------------------------ ROCK_Spur_ROCK ------------------------------------------------------------ CRIK_Spur_CRIK ------------------------------------------------------------ CC1G_07309_Ccin_GEK ------------------------------------------------------------ AqueK004_Aque_CRIK ------------------------------------------------------------ AqueK005_Aque_GEK NPLLLQIKSKVLPDKLIEKIETLCDQELKKLVGSKQVSTILLFLCDFIKNNPLIVCSEEL AqueK006_Aque_ROCK ------------------------------------------------------------ ROCK2_Hsap_ROCK ------------------------------------------------------------ ROCK1_Hsap_ROCK ------------------------------------------------------------ MRCKb_Hsap_GEK ------------------------------------------------------------ MRCKa_Hsap_GEK ------------------------------------------------------------ CG10522_Dmel_CRIK ------------------------------------------------------------ rok_Dmel_ROCK ------------------------------------------------------------ gek_Dmel_GEK ------------------------------------------------------------ MRCKb_Mmus_GEK ------------------------------------------------------------ MRCKa_Mmus_GEK ------------------------------------------------------------ DMPK2_Mmus_GEK ---------ETD------------------------------------------------ DMPK1_Mmus_GEK ---------Y-------------------------------------------------- CRIK_Mmus_CRIK ------------------------------------------------------------ let-502_Cele_ROCK ------------------------------------------------------------ K08B12.5_Cele_GEK ------------------------------------------------------------ DMPK2_Hsap_GEK ---------DAD------------------------------------------------ DMPK1_Hsap_GEK ---------H-------------------------------------------------- CRIK_Hsap_CRIK ------------------------------------------------------------ ROCK1_Mmus_ROCK ------------------------------------------------------------ ROCK2_Mmus_ROCK ------------------------------------------------------------ MRCK_Spur_GEK ------------------------------------------------------------ ROCK_Spur_ROCK ------------------------------------------------------------ CRIK_Spur_CRIK ------------------------------------------------------------ CC1G_07309_Ccin_GEK ------------------------------------------------------------ AqueK004_Aque_CRIK ------------------------------------------------------------ AqueK005_Aque_GEK QYIKNTINREGDELKIKQRTGVILYKAFQDQYFIDFKMTVPNEYPASHVQLEFKENNLPV AqueK006_Aque_ROCK ------------------------------------------------------------ ROCK2_Hsap_ROCK ------------------------------------------------------------ ROCK1_Hsap_ROCK ------------------------------------------------------------ MRCKb_Hsap_GEK --------------------PS-VTVPLRSMSD--------------PDQDFDKEPDSDS MRCKa_Hsap_GEK --------------------SA-KRQPMPSPSEGSLSSGGMDQGSDAPARDFDGE-DSDS CG10522_Dmel_CRIK -----------------------------------------------FKQKFNISMETL- rok_Dmel_ROCK ------------------------------------------------------------ gek_Dmel_GEK -----------------------------------------------------EQVDANS MRCKb_Mmus_GEK --------------------PG-VPVPLRSMSD--------------PDQDFDKEPDSDS MRCKa_Mmus_GEK --------------------NT-KRQPMPSPSEGSLSSGGMDQGSDAPARDYDGE-DSDS DMPK2_Mmus_GEK --------------------PLVKRKPWTSLSSESVS---CPQGSLS------------- DMPK1_Mmus_GEK ------------------------------------------TG---------------- CRIK_Mmus_CRIK --------------------ST-RRE-------------------RSPGRLF-----EDS let-502_Cele_ROCK ------------------------------------------------------------ K08B12.5_Cele_GEK -------------------------------------------------------LQ--S DMPK2_Hsap_GEK --------------------PM-KRKPWTSLSSESVS---CPQGSLS------------- DMPK1_Hsap_GEK ------------------------------------------AG---------------- CRIK_Hsap_CRIK --------------------ST-RRE-------------------RSPGRLF-----EDS ROCK1_Mmus_ROCK ------------------------------------------------------------ ROCK2_Mmus_ROCK ------------------------------------------------------------ MRCK_Spur_GEK --------------------FE-LSLTSRDGSQ----------GSQ----GS-PDLSGYS ROCK_Spur_ROCK ------------------------------------------------------------ CRIK_Spur_CRIK --------------------DR-ERE-------------------RREEEEE-----EER CC1G_07309_Ccin_GEK ---------------------------------------------HQPPRTYQYD-HEDT AqueK004_Aque_CRIK ------------------------------------------------------------ AqueK005_Aque_GEK NLYHIMKGQTVELLRQCVEPPI-RRNPRA--------------G-------------PFV AqueK006_Aque_ROCK -------------------------Q--RSTDVGGVGGGAANY----------------- ROCK2_Hsap_ROCK ------------------------------------------------------------ ROCK1_Hsap_ROCK ------------------------------------------------------------ MRCKb_Hsap_GEK TKHSTPSNS-------------------SNPSGPPSP----------------------- MRCKa_Hsap_GEK PRHSTASNS-------------------SNLSSPPSP----------------------- CG10522_Dmel_CRIK --------S-------------------S------------------------------- rok_Dmel_ROCK ----------------------------------P------------------------- gek_Dmel_GEK DDY--G-ND-------------------NIISRTPSP----------------------- MRCKb_Mmus_GEK TKHSTPSNS-------------------SNPSGPPSP----------------------- MRCKa_Mmus_GEK PRHSTASNS-------------------SNLSSPPSP----------------------- DMPK2_Mmus_GEK PAASLIQVS-------------------ER------------------------------ DMPK1_Mmus_GEK ------GL---------------------------------------------------- CRIK_Mmus_CRIK SRGR---LP-------------------AGAVRTPLS----------------------- let-502_Cele_ROCK ------------------------------------------------------------ K08B12.5_Cele_GEK -------NH-------------------SHT----------------------------- DMPK2_Hsap_GEK PATSLMQVS-------------------ER------------------------------ DMPK1_Hsap_GEK ------QL---------------------------------------------------- CRIK_Hsap_CRIK SRGR---LP-------------------AGAVRTPLS----------------------- ROCK1_Mmus_ROCK ------------------------------------------------------------ ROCK2_Mmus_ROCK ------------------------------------------------------------ MRCK_Spur_GEK PRHSLGEEA-------------------SSSGTPPTP----------------------- ROCK_Spur_ROCK ------------------------------------------------------------ CRIK_Spur_CRIK ERER---EK-------------------TGVKEPPLP----------------------- CC1G_07309_Ccin_GEK QHYSDEEDV-------------------DLLF---QG----------------------- AqueK004_Aque_CRIK ------------------------------------------------------------ AqueK005_Aque_GEK PRPSLQFITNYLVVDCLRSITTDSCPVCNKRALPTDPKDIIIDEGHPQYVYRIYCGHLYH AqueK006_Aque_ROCK -------------------------------GTVPGP----------------------- ROCK2_Hsap_ROCK ------------------------------------------------------------ ROCK1_Hsap_ROCK ------------------------------------------------------------ MRCKb_Hsap_GEK -------------------------------------NSPHR----S------------- MRCKa_Hsap_GEK -------------------------------------ASPRK----T------------- CG10522_Dmel_CRIK ------------------------------------------------------------ rok_Dmel_ROCK ------------------------------------------------------------ gek_Dmel_GEK -------------------------------------MAS-------------------- MRCKb_Mmus_GEK -------------------------------------NSPHR----S------------- MRCKa_Mmus_GEK -------------------------------------ISPQK----T------------- DMPK2_Mmus_GEK ----------------------------------------------P------------- DMPK1_Mmus_GEK ------------------------------------------------------------ CRIK_Mmus_CRIK ------------------------------------------------------------ let-502_Cele_ROCK ------------------------------------------------------------ K08B12.5_Cele_GEK ------------------------------------------------------------ DMPK2_Hsap_GEK ----------------------------------------------P------------- DMPK1_Hsap_GEK ------------------------------------------------------------ CRIK_Hsap_CRIK ------------------------------------------------------------ ROCK1_Mmus_ROCK ------------------------------------------------------------ ROCK2_Mmus_ROCK ------------------------------------------------------------ MRCK_Spur_GEK -------------------------------------HR--------------------- ROCK_Spur_ROCK ------------------------------------------------------------ CRIK_Spur_CRIK ------------------------------------------------------------ CC1G_07309_Ccin_GEK -------------------------------------ISK------SETDVGSLWDELEG AqueK004_Aque_CRIK ------------------------------------------------------------ AqueK005_Aque_GEK FQCLDSYMKTPPFTGGKKCVKCGQRVFHDKWNVPPRLAEERWAHQEA------------- AqueK006_Aque_ROCK -------------------------------------GGIGM----R------------- ROCK2_Hsap_ROCK --------------QNQSIRRPSRQLAPNKPS ROCK1_Hsap_ROCK --------------ANQSFRKVV-KNTSGKTS MRCKb_Hsap_GEK -----------------QL-PLEGLEQPACDT MRCKa_Hsap_GEK ----------------KSL-SLESTDRGSWDP CG10522_Dmel_CRIK --------------VAT--SVTLGSTVTGNSI rok_Dmel_ROCK --------------YAVNVQRSATLPANSSLK gek_Dmel_GEK ----------------------SFMDGLSNND MRCKb_Mmus_GEK -----------------QL-PMEGLDQPSCDA MRCKa_Mmus_GEK ----------------KSL-SLESTDRGSWDP DMPK2_Mmus_GEK ----------------RSL-P--PDPESESSP DMPK1_Mmus_GEK ----------------TPV-W--CFPGATFAP CRIK_Mmus_CRIK ---------------------QVNKVWDQSSV let-502_Cele_ROCK -------------------HAPGSSNSSTIYQ K08B12.5_Cele_GEK -----------------SS-DKDSLNRSVNND DMPK2_Hsap_GEK ----------------RSL-P--LSPELESSP DMPK1_Hsap_GEK ----------------TAV-W--RRPGAARAP CRIK_Hsap_CRIK ---------------------QVNKVWDQSSV ROCK1_Mmus_ROCK --------------ANQSFRKVV-KNTSGKTS ROCK2_Mmus_ROCK --------------QNQSIRRPSRQLAPNKPS MRCK_Spur_GEK -----------------------MSYAEQDQS ROCK_Spur_ROCK --------------SINSP-RYI-RAVEGTNP CRIK_Spur_CRIK ------------------------QMNNLMNE CC1G_07309_Ccin_GEK RHERMMYDIRMLEERLELVSRTVGGGSGRIRR AqueK004_Aque_CRIK ----------------L--RTKCTSLWMIWFI AqueK005_Aque_GEK ----------------RKR-EIAEVAEFLGFD AqueK006_Aque_ROCK --------------QIEFVRSNDSDTNPPQSQ