CLUSTAL W (1.83) multiple sequence alignment Egfr_Dmel MLLRRRNGPCPFPLLLLLLAH-CICIWPASA----------------------------- ErbB4_Mmus MKLA---TGLW-VWGSLLMA--A----GTVQ----------------------------- ErbB3_Mmus MSAI---GTLQ-VLGFLLS-L-A----RGSE----------------------------- ErbB2_Mmus MELA---AWCRW--GFLLA-L-L----SPG------------------------------ EGFR_Mmus MRPS---GTARTTLLVLLTAL-C----AAGG----------------------------- let-23_Cele MKFP---FLF--LFLIILIDTTI----DAASPTSTQGSVTVRRRQRKIVVRECMRYPPSI ErbB4_Hsap MKPA---TGLW-VWVSLLVA--A----GTVQ----------------------------- ErbB3_Hsap MRAN---DALQ-VLGLLFS-L-A----RGSE----------------------------- ErbB2_Hsap MELA---ALCRW--GLLLA-L-L----PPG------------------------------ EGFR_Hsap MRPS---GTAGAALLALLAAL-C----PASR----------------------------- EGFR_Spur MWRI---QQPK-R--I----V-C----T--Q----------------------------- AqueK263_Aque ------------------------------------------------------------ AqueK264_Aque ML---------------------------------------------------------- AqueK265_Aque MQMM---LELQL------------------------------------------------ AqueK266_Aque MVFS---SNGQVE---------------P------------------------------- Egfr_Dmel ----------------ARDRYARQNNRQRHQDIDRDRDRDRFLYRSSSAQNRQRGGANFA ErbB4_Mmus ------------------------------------------------------------ ErbB3_Mmus ------------------------------------------------------------ ErbB2_Mmus ------------------------------------------------------------ EGFR_Mmus ------------------------------------------------------------ let-23_Cele GSILLIIPIFLTFFGNS------------------------------------------- ErbB4_Hsap ------------------------------------------------------------ ErbB3_Hsap ------------------------------------------------------------ ErbB2_Hsap ------------------------------------------------------------ EGFR_Hsap ------------------------------------------------------------ EGFR_Spur ------------------------------------------------------------ AqueK263_Aque ------------------------------------------------------------ AqueK264_Aque ------------------------------------------------------------ AqueK265_Aque ------------------------------------------------------------ AqueK266_Aque ------------------------------------------------------------ Egfr_Dmel LGLGANGVTIPTSLEDKNKN-------EFVKGKICIGTKSRLSVPSN------KEHHYRN ErbB4_Mmus ---------------------------PSASQSVCAGTENKLSSLSD------LEQQYRA ErbB3_Mmus ---------------------------MGNSQAVCPGTLNGLSVTGD------ADNQYQT ErbB2_Mmus ----------------------------AAGTQVCTGTDMKLRLPAS------PETHLDM EGFR_Mmus ---------------------------ALEEKKVCQGTSNRLTQLGT------FEDHFLS let-23_Cele -------------------NAQLWKRCVSPQDCLCSGTTNGISRYGT-------GNILED ErbB4_Hsap ---------------------------PSDSQSVCAGTENKLSSLSD------LEQQYRA ErbB3_Hsap ---------------------------VGNSQAVCPGTLNGLSVTGD------AENQYQT ErbB2_Hsap ----------------------------AASTQVCTGTDMKLRLPAS------PETHLDM EGFR_Hsap ---------------------------ALEEKKVCQGTSNKLTQLGT------FEDHFLS EGFR_Spur ---------------------------IRGRPRVCTGTDQGTAKPYNSDNAGARQQYYEE AqueK263_Aque -------------------------------ETICLGHSTSRVSQSQGDS---VSSILKD AqueK264_Aque ------------------------------------------------------------ AqueK265_Aque ----------------------------FIIETICLGHSTNRVSQSQGGT---VSSILQD AqueK266_Aque ---------------------------DCPLKSICLGHSTNRVSQSQGDS---VSSILQD Egfr_Dmel LRDRYTNCTYVDGNLEL---------TWLPNEN----------------------LDLSF ErbB4_Mmus LRKYYENCEVVMGNLEI---------TSI-EHN----------------------RDLSF ErbB3_Mmus LYKLYEKCEVVMGNLEI---------VLT-GHN----------------------ADLSF ErbB2_Mmus LRHLYQGCQVVQGNLEL---------TYL-PAN----------------------ASLSF EGFR_Mmus LQRMYNNCEVVLGNLEI---------TYV-QRN----------------------YDLSF let-23_Cele LETMYRGCRRVYGNLEI---------TWI-EANEIKKWRESTNSTVDPKNEDSPLKSINF ErbB4_Hsap LRKYYENCEVVMGNLEI---------TSI-EHN----------------------RDLSF ErbB3_Hsap LYKLYERCEVVMGNLEI---------VLT-GHN----------------------ADLSF ErbB2_Hsap LRHLYQGCQVVQGNLEL---------TYL-PTN----------------------ASLSF EGFR_Hsap LQRMFNNCEVVLGNLEI---------TYV-QRN----------------------YDLSF EGFR_Spur LKDRYTNCTYVDGNLEI---------SFLHEQE----------------------YDLGF AqueK263_Aque AYEQFCGSEYIEDNIVIRTGSGLVDISQP-LVE----------------------ANFSF AqueK264_Aque ------------------------------------------------------------ AqueK265_Aque AYEQFCGCRYIKDNIVIQTGPTLVDANQT-LVE----------------------ANFSF AqueK266_Aque AYEQFCGCRYIEDNIVIRTGSGLVDISQP-LVE----------------------ANFSF Egfr_Dmel LDNIREVTGYILI-SHVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFVTY--------- ErbB4_Mmus LRSIREVTGYVLV-ALNQFRYLPLENLRIIRGTKLY-----EDRYALAIFLNYRKD---- ErbB3_Mmus LQWIREVTGYVLV-AMNEFSVLPLPNLRVVRGTQVY-----DGKFAIFVMLNYNTN---- ErbB2_Mmus LQDIQEVQGYMLI-AHNRVKHVPLQRLRIVRGTQLF-----EDKYALAVLDNRDPLDNVT EGFR_Mmus LKTIQEVAGYVLI-ALNTVERIPLENLQIIRGNALY-----ENTYALAILSNYGTN---- let-23_Cele FDNLEEIRGSLII-YRANIQKISFPRLRVIYGDEVF-----HDN-ALYIHKN-------- ErbB4_Hsap LRSVREVTGYVLV-ALNQFRYLPLENLRIIRGTKLY-----EDRYALAIFLNYRKD---- ErbB3_Hsap LQWIREVTGYVLV-AMNEFSTLPLPNLRVVRGTQVY-----DGKFAIFVMLNYNTN---- ErbB2_Hsap LQDIQEVQGYVLI-AHNQVRQVPLQRLRIVRGTQLF-----EDNYALAVLDNGDPLNNT- EGFR_Hsap LKTIQEVAGYVLI-ALNTVERIPLENLQIIRGNMYY-----ENSYALAVLSNYDAN---- EGFR_Spur LSSIREVTGYILI-LLTYSRVIPLTNLRVIRGTKLY-----DDKYALYVALTFHTG---- AqueK263_Aque LYYVKEISGYLELNNIPSIERLSLPRLRLIRGRNLR-----SGRYSLLVSG--------- AqueK264_Aque ------------------------------------------------------------ AqueK265_Aque LYYVKEISGYLELNGIPSIERLSLPNLRIIRGRNLR-----SGRYSLLALG--------- AqueK266_Aque LYYVIEISGYLELNNIPSIERLSLPRLRLIRGRNLR-----SGRYSLLVSG--------- Egfr_Dmel --------SKMYTLEIPDLRDVLNGQVGFH---NNYNLCHM-RTIQWSEIVSNGTDAYYN ErbB4_Mmus ------GNFGLQELGLKNLTEILNGGVYVD---QNKFLCYA-DTIHWQDIVRNPWPSNMT ErbB3_Mmus ------SSHALRQLRFTQLTEILLGGVYIE---KNDKLCHM-DTIDWRDIVRVPD-A--E ErbB2_Mmus TAAPGRTPEGLRELQLRSLTEILKGGVLIR---GNPQLCYQ-DMVLWKDVLRKNNQLAPV EGFR_Mmus -------RTGLRELPMRNLQEILIGAVRFS---NNPILCNM-DTIQWRDIVQNVFMSNMS let-23_Cele --------DKVHEVVMRELRVIRNGSVTIQ---DNPKMCYIGDKIDWKELLYDPDVQKVE ErbB4_Hsap ------GNFGLQELGLKNLTEILNGGVYVD---QNKFLCYA-DTIHWQDIVRNPWPSNLT ErbB3_Hsap ------SSHALRQLRLTQLTEILSGGVYIE---KNDKLCHM-DTIDWRDIVRDRD-A--E ErbB2_Hsap TPVTGASPGGLRELQLRSLTEILKGGVLIQ---RNPQLCYQ-DTILWKDIFHKNNQLALT EGFR_Hsap -------KTGLKELPMRNLQEILHGAVRFS---NNPALCNV-ESIQWRDIVSSDFLSNMS EGFR_Spur -----DPTIATEEMWLTSLHEILKGDVYFH---QNNQLCYV-ETIAWDDMQPGL-VANIS AqueK263_Aque ---------RIETLHMPSLTEISRGDVMLGSSSLNSYLCNT-RSINWTDIAPFPVSG-HQ AqueK264_Aque ------------------------------------------------------------ AqueK265_Aque ---------KIQNLYMPNLTEISRGDVWFIS-RLNPYLCNT-RSINWIDIAPFPVIG-HR AqueK266_Aque ---------RIETLYMPRLTEISRGDVLLGSSSLNSYLCNT-RSINWTDIAPFPVSG-HQ Egfr_Dmel YD-----FTAPERECP--KCHE-SCT-HGCWGEGPKNCQKFSKLTCSPQCAGGRCYG--- ErbB4_Mmus LV-----STNGSSGCG--RCHK-SCT-GRCWGPTENHCQTLTRTVCAEQCD-GRCYG--- ErbB3_Mmus IV-----VKNNGGNCP--PCHE-VCK-GRCWGPGPEDCQILTKTICAPQCN-GRCFG--- ErbB2_Mmus DM-----DTNRSRACP--PCAP-TCKDNHCWGESPEDCQILTGTICTSGCA--RCKG--- EGFR_Mmus MD-----LQSHPSSCP--KCDP-SCPNGSCWGGGEENCQKLTKIICAQQCS-HRCRG--- let-23_Cele TTNSHQHCYQNGKSMA--KCHE-SCN-DKCWGSGDNDCQRVYRSVCPKSCS--QCFYSNS ErbB4_Hsap LV-----STNGSSGCG--RCHK-SCT-GRCWGPTENHCQTLTRTVCAEQCD-GRCYG--- ErbB3_Hsap IV-----VKDNGRSCP--PCHE-VCK-GRCWGPGSEDCQTLTKTICAPQCN-GHCFG--- ErbB2_Hsap LI-----DTNRSRACH--PCSP-MCKGSRCWGESSEDCQSLTRTVCAGGCA--RCKG--- EGFR_Hsap MD-----FQNHLGSCQ--KCDP-SCPNGSCWGAGEENCQKLTKIICAQQCS-GRCRG--- EGFR_Spur MW-----DEHAQRNCSEHRCHE-SCN-GHCWGPGEEHCQILTLKDCSSTCD-YRCRG--- AqueK263_Aque FS-----RTD-------------------------------------------------- AqueK264_Aque ------------------------------------------------------------ AqueK265_Aque L------ETNGCSDS-----A-QG-PAGAMILTAVKHCHLIAIAITIVA----------- AqueK266_Aque FS-----GTDGCSDIDIIDCNALGCSSGFCWCNDTDCCQTLSF-NCNCNN--SRCFRDGQ Egfr_Dmel PKPRECCHLFCAGGCTGP------------------------------------TQKDCI ErbB4_Mmus PYVSDCCHRECAGGCSGP------------------------------------KDTDCF ErbB3_Mmus PNPNQCCHDECAGGCSGP------------------------------------QDTDCF ErbB2_Mmus RLPTDCCHEQCAAGCTGP------------------------------------KHSDCL EGFR_Mmus RSPSDCCHNQCAAGCTGP------------------------------------RESDCL let-23_Cele TSSYECCDSACLGGCTGH------------------------------------GPKNCI ErbB4_Hsap PYVSDCCHRECAGGCSGP------------------------------------KDTDCF ErbB3_Hsap PNPNQCCHDECAGGCSGP------------------------------------QDTDCF ErbB2_Hsap PLPTDCCHEQCAAGCTGP------------------------------------KHSDCL EGFR_Hsap KSPSDCCHNQCAAGCTGP------------------------------------RESDCL EGFR_Spur PTQADCCHRSCAGGCTNS------------------------------------SNAGCL AqueK263_Aque -----GCND-LAQGFAGVMTLIAAKHYHLIAIATTIVVVSEMVQTYNVAIRSVLLVAVVM AqueK264_Aque ------------------------------------------------------------ AqueK265_Aque ---SEMVQTYSVAIQS------------------------------------VLLVAVKV AqueK266_Aque --NIHCCHPECVAGCSGY------------------------------------DNSQCF Egfr_Dmel ACKNFFDEGVCKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPG----HLLR-DNG ErbB4_Mmus ACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPH----NFVV-DSS ErbB3_Mmus ACRHFNDSGACVPRCPAPLVYNKLTFQLEPNPHIKYQYGGVCVASCPH----NFVV-DQT ErbB2_Mmus ACLHFNHSGICELHCPALITYNTDTFESMLNPEGRYTFGASCVTTCPY----NYLSTEVG EGFR_Mmus VCQKFQDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPR----NYVVTDHG let-23_Cele ACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECPP----ELLI-END ErbB4_Hsap ACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPH----NFVV-DSS ErbB3_Hsap ACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPH----NFVV-DQT ErbB2_Hsap ACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPY----NYLSTDVG EGFR_Hsap VCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPR----NYVVTDHG EGFR_Spur ACRQFSLDNTCVETCPRRYEYDRNTFTNVENPNFRYSYGSRCLKDCPN----NVLV-DGD AqueK263_Aque ACKNVLDDGVCRERCPEQYIIDPFARTVIPNPLFKLEAKPLCVYSCPDPFRNNFLHEHGT AqueK264_Aque ------------------------------------------------------FEL-GT AqueK265_Aque ACKNVLNDGVCRERCPEQYIIDPDTRAVVLNPEFKFEAQPLCVSTCPA----MLFEL-GT AqueK266_Aque ACKNVLNVGACQERCPNQFIINPFTRTFIPNPEFKLEAQPLCVSSCPD----MLFQV-DT . Egfr_Dmel ACVRSCPQDKMDKG-----GECVPCN-GPCPKTCPGVTV--------LHAGNIDSFRNCT ErbB4_Mmus SCVRACPSSKMEVE-ENGIKMCKPCT-DICPKACDGIGTGSLMSAQTVDSSNIDKFINCT ErbB3_Mmus FCVRACPADKMEVD-KNGLKMCEPCR-GLCPKACEGTGSGSR--YQTVDSSNIDGFVNCT ErbB2_Mmus SCTLVCPPNNQEVTAEDGTQRCEKCS-KPCAGVCYGLGMEHLRGARAITSDNIQEFAGCK EGFR_Mmus SCVRACGPDYYEVE-EDGIRKCKKCD-GPCRKVCNGIGIGEFKDTLSINATNIKHFKYCT let-23_Cele VCVRHCSDGHHYDA-TKDVRECEKCRSSSCPKICTVDGH--------LTNETLKNLEGCE ErbB4_Hsap SCVRACPSSKMEVE-ENGIKMCKPCT-DICPKACDGIGTGSLMSAQTVDSSNIDKFINCT ErbB3_Hsap SCVRACPPDKMEVD-KNGLKMCEPCG-GLCPKACEGTGSGSR--FQTVDSSNIDGFVNCT ErbB2_Hsap SCTLVCPLHNQEVTAEDGTQRCEKCS-KPCARVCYGLGMEHLREVRAVTSANIQEFAGCK EGFR_Hsap SCVRACGADSYEME-EDGVRKCKKCE-GPCRKVCNGIGIGEFKDSLSINATNIKHFKNCT EGFR_Spur NCVKVCGPGKKEQD-----NQCIPCE-GVCPSTCDGIGDDGALSSK---HIRSKQFDNCT AqueK263_Aque QCVKDCPSNYMPVP-SNRTMRCVLCN-DTCPKECTGG-V--------FDYNDPGKLTGCT AqueK264_Aque QCVEDCPSNYMPVV-NNGIMRCLSCD-GPCPQECTGG-V--------FDYNDPGKLTGCT AqueK265_Aque QCVEDCPSNYMSVSGDNGTMRCVLCD-GPCPQECAGG-V--------FDYDVPGKLSGCT AqueK266_Aque QCVKNCPSNYMPVA-NNGTMRCVLCN-DTCPKKCTGG-V--------FDYNNPGKLTGCT *. * * * * * : * Egfr_Dmel VIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFR ErbB4_Mmus KINGNLIFLVTGIHGDP--Y------NAIDAIDPEKLNVFRTVREITGFLNIQSWPPNMT ErbB3_Mmus KILGNLDFLITGLNGDP--W------HKIPALDPEKLNVFRTVREITGYLNIQSWPPHMH ErbB2_Mmus KIFGSLAFLPESFDGNP--S------SGVAPLKPEHLQVFETLEEITGYLYISAWPESFQ EGFR_Mmus AISGDLHILPVAFKGDS--F------TRTPPLDPRELEILKTVKEITGFLLIQAWPDNWT let-23_Cele QIDGHLIIE-H-------------------AFTYEQLKVLETVKIVSEYITIV--QQNFY ErbB4_Hsap KINGNLIFLVTGIHGDP--Y------NAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMT ErbB3_Hsap KILGNLDFLITGLNGDP--W------HKIPALDPEKLNVFRTVREITGYLNIQSWPPHMH ErbB2_Hsap KIFGSLAFLPESFDGDP--A------SNTAPLQPEQLQVFETLEEITGYLYISAWPDSLP EGFR_Hsap SISGDLHILPVAFRGDS--F------THTPPLDPQELDILKTVKEITGFLLIQAWPENRT EGFR_Spur QINGNLIITSHTFTGDA--F------AGTTPIDPSALEIFRTVKQITGYLSVQGLHQHFT AqueK263_Aque VITTELRISSVPPNVKLVLHIAKILWQKL--SSPSILNDLNDIREICGSLDISGFNK--E AqueK264_Aque VITTELRISSVPPNVKLVLYIAKILWQNL--SSLSILNDLNGIREIRGSLDISGFNK--N AqueK265_Aque IITTELRISSVPPNL-----------------DPSILNDLNEIREIRGSLDISGFNK--E AqueK266_Aque VITTDLRILSVPVN-----------------VNLSILNDLKDIREIRGSLDISGFNK--E * : : *. : :. : : : Egfr_Dmel NLSYFRNLETIHGRQLMES-----------MFAAL-AIVKSSLYSLEMRNLKQISSGSVV ErbB4_Mmus DFSVFSNLVTIGGRVLYSG------------LSLL-ILKQQGITSLQFQSLKEISAGNIY ErbB3_Mmus NFSVFSNLTTIGGRSLYNR------------GFSLLIMKNLNVTSLGFRSLKEISAGRVY ErbB2_Mmus DLSVFQNLRVIRGRILHDG------------AYSL-TLQGLGIHSLGLRSLRELGSGLAL EGFR_Mmus DLHAFENLEIIRGRTKQHG------------QFSL-AVVGLNITSLGLRSLKEISDGDVI let-23_Cele DLKFLKNLQIIEGRKLHNV------------RWALAIYQCDDLEELSLNSLKLIKTGAVL ErbB4_Hsap DFSVFSNLVTIGGRVLYSG------------LSLL-ILKQQGITSLQFQSLKEISAGNIY ErbB3_Hsap NFSVFSNLTTIGGRSLYNR------------GFSLLIMKNLNVTSLGFRSLKEISAGRIY ErbB2_Hsap DLSVFQNLQVIRGRILHNG------------AYSL-TLQGLGISWLGLRSLRELGSGLAL EGFR_Hsap DLHAFENLEIIRGRTKQHG------------QFSL-AVVSLNITSLGLRSLKEISDGDVI EGFR_Spur NLSMFSNLERIDGRNLYGE----------PPFASLAILDNQHLEALSLISLNELKLGGAY AqueK263_Aque TFPYLSSLKTVGNDST-QVLSQSCNGSSDSTKFSV-IIANTDLVSIDLSSLETVINGGIQ AqueK264_Aque TFPYLSNLKTVGNDST-QVLSQSCNGSSDSTKFSV-IIADTDLISIDLSSLETVINGGIR AqueK265_Aque TFPYLYNLKTVGNNDSNQVLSQSCNGSSDSFKYSI-IIADTELVSIDLSSLEAVINGGVR AqueK266_Aque TFPYLSNLKTVGNDSS-QVLSQSCNGSSDSIQFSI-IIANTDLVSIDLSSLEAVINGGIQ : : .* : . : : : : .*. : * Egfr_Dmel IQHNRDLCYVSNIRWPAIQKEP----EQKVWVNENLRADLCEKNGTICSDQCNE--DGCW ErbB4_Mmus ITDNSNLCYYHTINWTTLFSTI----NQRIVIRDNRRAENCTAEGMVCNHLCSN--DGCW ErbB3_Mmus ISANQQLCYHHSLNWTRLLRGPA---EERLDIKYNRPLGECVAEGKVCDPLCSS--GGCW ErbB2_Mmus IHRNTHLCFVNTVPWDQLFRNP----HQALLHSGNRPEEACGLEGLVCNSLCAR--GHCW EGFR_Mmus ISGNRNLCYANTINWKKLFGTP----NQKTKIMNNRAEKDCKAVNHVCNPLCSS--EGCW let-23_Cele IMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNK--RGCW ErbB4_Hsap ITDNSNLCYYHTINWTTLFSTI----NQRIVIRDNRKAENCTAEGMVCNHLCSS--DGCW ErbB3_Hsap ISANRQLCYHHSLNWTKVLRGPT---EERLDIKHNRPRRDCVAEGKVCDPLCSS--GGCW ErbB2_Hsap IHHNTHLCFVHTVPWDQLFRNP----HQALLHTANRPEDECVGEGLACHQLCAR--GHCW EGFR_Hsap ISGNKNLCYANTINWKKLFGTS----GQKTKIISNRGENSCKATGQVCHALCSP--EGCW EGFR_Spur VQNNRLLCYSEETAFDAVIN-PE----YSVSFVNNKDRATCIAENKTCDPQCAD--IGCW AqueK263_Aque LENNPSLCYLGNLSYYLANASS----SSCVLDNHRSSINECVKMKMTCHPQCSSASGWCW AqueK264_Aque LQNNPSLCYLGNLSYYLANASS----SSCVLDNHRRRIDECVEMSMTCHPQCSSASGWCW AqueK265_Aque LQNNPSLCYLGDLRYYLTNSSA----TSCILDDHRQSIEECVETNMTCHPQCSSASGWCW AqueK266_Aque LENNPSLCYLGNLSYYLANASS----SSCVLDNHKRSIDECVEMNMTCHSQCSSASGWCW : * **: : . * * * ** Egfr_Dmel GAGTDQCLTCKNFNFNGTCIADCGYISNAY-KF-D----NRTCKICHPECR--------- ErbB4_Mmus GPGPDQCLSCRRFSRGKICIESCNLYDGEFREFEN----GSICVECDSQCEK-------- ErbB3_Mmus GPGPGQCLSCRNYSREGVCVTHCNVLQGEPREFVH----EAHCFSCHPECQP-------- ErbB2_Mmus GPGPTQCVNCSQFLRGQECVEECRVWKGLPREYVR----GKHCLPCHPECQP-------- EGFR_Mmus GPEPRDCVSCQNVSRGRECVEKCNILEGEPREFVE----NSECIQCHPECLP-------- let-23_Cele GKEPEDCLECKTWKSVGTCVEKCDT-KGFLRN-QT----SMKCERCSPECE--------- ErbB4_Hsap GPGPDQCLSCRRFSRGRICIESCNLYDGEFREFEN----GSICVECDPQCEK-------- ErbB3_Hsap GPGPGQCLSCRNYSRGGVCVTHCNFLNGEPREFAH----EAECFSCHPECQP-------- ErbB2_Hsap GPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVN----ARHCLPCHPECQP-------- EGFR_Hsap GPEPRDCVSCRNVSRGRECVDKCNLLEGEPREFVE----NSECIQCHPECLP-------- EGFR_Spur GPGPRQCAKCKNAIIGDTCIEACDLDNGQYVETEASASEAAVCEHCDTQCSAGCSGPEPD AqueK263_Aque GPNDTQCVTCTNFIFNKQCVPDCHDFDTHRVxxx-------------------------- AqueK264_Aque GPNDTQCVTCTNFIFNGQCVPDCHDFDTYGIHLFNH-NANNTCLPCHSFCN--------- AqueK265_Aque GPNDTQCVTCTNFIFNGQCVPTCNDFDAHGVHLYGH-NANNTCLACHSFCS--------- AqueK266_Aque GPNDTQCVTCTNFSFNGQCVPDCHNFDAHGIKNV-------------------------- * :* * *: * . Egfr_Dmel ------------------------------------------------------------ ErbB4_Mmus ------------------------------------------------------------ ErbB3_Mmus ------------------------------------------------------------ ErbB2_Mmus ------------------------------------------------------------ EGFR_Mmus ------------------------------------------------------------ let-23_Cele ------------------------------------------------------------ ErbB4_Hsap ------------------------------------------------------------ ErbB3_Hsap ------------------------------------------------------------ ErbB2_Hsap ------------------------------------------------------------ EGFR_Hsap ------------------------------------------------------------ EGFR_Spur QCDCQSDSTGTNCRRMCRNVQDGPFCRAECPEPKFANAQKNCTDCHSNCLKGCNGPENNL AqueK263_Aque ------------------------------------------------------------ AqueK264_Aque ------------------------------------------------------------ AqueK265_Aque ------------------------------------------------------------ AqueK266_Aque ------------------------------------------------------------ Egfr_Dmel ------------------------------------------------------------ ErbB4_Mmus -------------------------------------------------------MEDGL ErbB3_Mmus -------------------------------------------------------ME-GT ErbB2_Mmus -------------------------------------------------------QN-SS EGFR_Mmus -------------------------------------------------------QA-MN let-23_Cele ------------------------------------------------------------ ErbB4_Hsap -------------------------------------------------------MEDGL ErbB3_Hsap -------------------------------------------------------ME-GT ErbB2_Hsap -------------------------------------------------------QN-GS EGFR_Hsap -------------------------------------------------------QA-MN EGFR_Spur GEDGCLECPQVMLDYNRKVMECMLINTPCSDDYFYDRISHSEKSDPLAGSVICQQCDPMC AqueK263_Aque ------------------------------------------------------------ AqueK264_Aque ------------------------------------------------------------ AqueK265_Aque ------------------------------------------------------------ AqueK266_Aque ------------------------------------------------------------ Egfr_Dmel -TCNGAGAD---------------HC-------QE-CVH--------------------- ErbB4_Mmus LTCHGPGPD---------------NC-------TK-CSH--------------------- ErbB3_Mmus STCNGSGSD---------------AC-------AR-CAH--------------------- ErbB2_Mmus ETCYGSEAD---------------QC-------EA-CAH--------------------- EGFR_Mmus ITCTGRGPD---------------NC-------IQ-CAH--------------------- let-23_Cele -TCNGLGEL---------------DC-------LT-CRHKTLYN---------------- ErbB4_Hsap LTCHGPGPD---------------NC-------TK-CSH--------------------- ErbB3_Hsap ATCNGSGSD---------------TC-------AQ-CAH--------------------- ErbB2_Hsap VTCFGPEAD---------------QC-------VA-CAH--------------------- EGFR_Hsap ITCTGRGPD---------------NC-------IQ-CAH--------------------- EGFR_Spur IGCDGAGPR---------------RC-------KQ-CKL--------------------- AqueK263_Aque -----xxxxxxxxxxxxxxxxxxxxxxxxxxxxxx-xxxxxxxxxxxxxxxxxxxxxxxx AqueK264_Aque GSCVGEGPA---------------NC-------SS-CNTYFFVN---------------- AqueK265_Aque GSCVGEGPA---------------NC-------SSSCNTNFFVN---------------- AqueK266_Aque -----QGPA---------------NC-------SI-CNTDFFVN---------------- Egfr_Dmel ------------------------------------------------------------ ErbB4_Mmus ------------------------------------------------------------ ErbB3_Mmus ------------------------------------------------------------ ErbB2_Mmus ------------------------------------------------------------ EGFR_Mmus ------------------------------------------------------------ let-23_Cele ------------------------------------------------------------ ErbB4_Hsap ------------------------------------------------------------ ErbB3_Hsap ------------------------------------------------------------ ErbB2_Hsap ------------------------------------------------------------ EGFR_Hsap ------------------------------------------------------------ EGFR_Spur ------------------------------------------------------------ AqueK263_Aque xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx AqueK264_Aque ------------------------------------------------------------ AqueK265_Aque ------------------------------------------------------------ AqueK266_Aque ------------------------------------------------------------ Egfr_Dmel --------------------------------------VRDGQHCVSEC----PKNKYND ErbB4_Mmus --------------------------------------FKDGPNCVEKC----PDGLQGA ErbB3_Mmus --------------------------------------FRDGPHCVNSC----PHGILGA ErbB2_Mmus --------------------------------------YKDSSSCVARC----PSGVKPD EGFR_Mmus --------------------------------------YIDGPHCVKTC----PAGIMGE let-23_Cele -----------------------------------SD-FGNRMECVHDC----PVS---- ErbB4_Hsap --------------------------------------FKDGPNCVEKC----PDGLQGA ErbB3_Hsap --------------------------------------FRDGPHCVSSC----PHGVLGA ErbB2_Hsap --------------------------------------YKDPPFCVARC----PSGVKPD EGFR_Hsap --------------------------------------YIDGPHCVKTC----PAGVMGE EGFR_Spur --------------------------------------FRQDDECVDEC----RSGF--- AqueK263_Aque xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx AqueK264_Aque -----------------------------------VS-IGVGKLCLESC----VGDTYLP AqueK265_Aque -----------------------------------VS-VGVGIQCLESC----VGDTYLP AqueK266_Aque -----------------------------------VS-IGVGIECLESC----VGDTYLP Egfr_Dmel R----GVCRECHATC---DGCTGPKDTIG-IGACTTCNLAIINNDATVKRCLLKDDKCPD ErbB4_Mmus N----S------------------------------------------------------ ErbB3_Mmus K----G------------------------------------------------------ ErbB2_Mmus L----S-----------------------------------------------------Y EGFR_Mmus N----N------------------------------------------------------ let-23_Cele ------------------------------------------------------------ ErbB4_Hsap N----S------------------------------------------------------ ErbB3_Hsap K----G------------------------------------------------------ ErbB2_Hsap L----S-----------------------------------------------------Y EGFR_Hsap N----N------------------------------------------------------ EGFR_Spur ------------------------------------------------------------ AqueK263_Aque xxx--------------------------------------------------------- AqueK264_Aque DDCTSGECLPCFDGCTLSNGCAGPGKTFNNSNGCIACDTILLDRNGEQIECQ-RDVTCPS AqueK265_Aque DSRTSGECLPCFSGCSLGYGCAGPGKTFNDSNGCMACDTILLDRNGDQIECQ-RDVTCPS AqueK266_Aque DDR--------------------------------------------------------- Egfr_Dmel GYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCTNYGYHEQVCSKCTHYKRREQCETEC ErbB4_Mmus -FIF-------------------------------------------------------- ErbB3_Mmus -PIY-------------------------------------------------------- ErbB2_Mmus MPIW-------------------------------------------------------- EGFR_Mmus TLVW-------------------------------------------------------- let-23_Cele ------------------------------------------------------------ ErbB4_Hsap -FIF-------------------------------------------------------- ErbB3_Hsap -PIY-------------------------------------------------------- ErbB2_Hsap MPIW-------------------------------------------------------- EGFR_Hsap TLVW-------------------------------------------------------- EGFR_Spur ------------------------------------------------------------ AqueK263_Aque ------------------------------------------------------------ AqueK264_Aque GYYREILS-EDRGI---------------------------------------------- AqueK265_Aque GYYWEQLT-EDRGI---------------------------------------------- AqueK266_Aque ------------------------------------------------------------ Egfr_Dmel PADHYTDEEQRECFQCHPECN---GCTGPGADD----CKS-------------CR----- ErbB4_Mmus ---KYAD-QDRECHPCHPNCT--QGCNGPTSHD----CIY-------------YP----- ErbB3_Mmus ---KYPD-AQNECRPCHENCT--QGCKGPELQD----CLG-------------Q------ ErbB2_Mmus ---KYPD-EEGICQPCPINCT--HSCVDLDERG----CPA-------------------- EGFR_Mmus ---KYAD-ANNVCHLCHANCT--YGCAGPGLQG----CEV-------------------- let-23_Cele ---HFPT-QKNVCEKCHPTCYD-NGCTGPDSNLGYGGCKQCKYAVKYENDTIFCLQSSGM ErbB4_Hsap ---KYAD-PDRECHPCHPNCT--QGCNGPTSHD----CIY-------------YP----- ErbB3_Hsap ---KYPD-VQNECRPCHENCT--QGCKGPELQD----CLG-------------Q------ ErbB2_Hsap ---KFPD-EEGACQPCPINCT--HSCVDLDDKG----CPA-------------------- EGFR_Hsap ---KYAD-AGHVCHLCHPNCT--YGCTGPGLEG----CPT-------------------- EGFR_Spur ----YPD-VDDMCQPCHPQCR--Q-CFNGTVHD----CLD-------------CE----- AqueK263_Aque --------xxxxxxxxxxxxxxxx--xxxxxxx----xx--------------------- AqueK264_Aque ----FFT-GTVLCHSCHELCA---TCSGPSVSD----CVL-------------CS----- AqueK265_Aque ----FLT-DTVLCHSCHELCA---TCSGPSVSD----CVL-------------CS----- AqueK266_Aque --------TSGECLPCFNGCTLGNGCAGPGKTF----ND--------------------- Egfr_Dmel ----------------------------------------------------NFKLFDAN ErbB4_Mmus ----------------------------------------------------WT----GH ErbB3_Mmus ------------------------------------------------------------ ErbB2_Mmus ------------------------------------------------------------ EGFR_Mmus ------------------------------------------------------------ let-23_Cele NNVCVENDLPNYYISTYDTEGVIETHCEKCSISCKTCSSAGRNVVQNKCVCKH------- ErbB4_Hsap ----------------------------------------------------WT----GH ErbB3_Hsap ------------------------------------------------------------ ErbB2_Hsap ------------------------------------------------------------ EGFR_Hsap ------------------------------------------------------------ EGFR_Spur ----------------------------------------------------SYTVQTGE AqueK263_Aque ----------------------------------------------------xx------ AqueK264_Aque ----------------------------------------------------YIRGTNGS AqueK265_Aque ----------------------------------------------------YIRGTNGS AqueK266_Aque ------------------------------------------------------------ Egfr_Dmel E---T---------------GPYVNS-T-------------------------------- ErbB4_Mmus ------------------------------------------------------------ ErbB3_Mmus ------------------------------------------------------------ ErbB2_Mmus ------------------------------------------------------------ EGFR_Mmus ------------------------------------------------------------ let-23_Cele -------------VEYQPNPSERICMDQCPVNSFMVPDTNNTVCKKCHHECDQNYHCANG ErbB4_Hsap ------------------------------------------------------------ ErbB3_Hsap ------------------------------------------------------------ ErbB2_Hsap ------------------------------------------------------------ EGFR_Hsap ------------------------------------------------------------ EGFR_Spur N---TFFCALSCPAEYPNELSPYVCGKTCPT--LFFPNAM-SKCEGCHTECK--DGCHNG AqueK263_Aque ------------------------------------------------------------ AqueK264_Aque CVYMC---------------DP--------------------IRETVPM----------- AqueK265_Aque CVFMC---------------DP--------------------IRETVPM----------- AqueK266_Aque ------------------------------------------------------------ Egfr_Dmel -------------MFNCTS----KCPLEMRHVNYQYT-AIG---PYC----AASPP-RSS ErbB4_Mmus ---------------------------------------------------STL--PQHA ErbB3_Mmus ---------------------------------------------------AE---VLMS ErbB2_Mmus -----------------------------------------------------E--QRAS EGFR_Mmus -----------------------------------------------------W--PSGP let-23_Cele QSTGCQKCKNFTVFKGDIAQCVSECPKNLPFSNPA----NGECLDYD-----IA--SRQR ErbB4_Hsap ---------------------------------------------------STL--PQHA ErbB3_Hsap ---------------------------------------------------TL---VLIG ErbB2_Hsap -----------------------------------------------------E--QRAS EGFR_Hsap ---------------------------------------------------------NGP EGFR_Spur TRSGCYACKNVVVNLECRA----ECPAAYKNTNGTCLYIHG---PDQ----KATPKPGGG AqueK263_Aque -----------------------------------------------xxxxxxx--xx-x AqueK264_Aque ---------------NGSS----QCI------------------LVTGTMGTLD--PTGA AqueK265_Aque ---------------NGSS----QCI------------------PVT--MGTID--PSSA AqueK266_Aque -----------------------------------------------SNGCSAC--DT-- Egfr_Dmel KI-TANLDVNMIFIITGAVL---VPTICILCVVTYICRQKQKAKKETVKM------TMAL ErbB4_Mmus RT-P-----LIAAGVIGGLF---ILVIMALTFAV-YVRRKSIKKKRAL--------RRFL ErbB3_Mmus KP-H------LVIAVTVGLT---VIFLILGGSFL-YWRGRRIQNKRAM--------RRYL ErbB2_Mmus PV-T-----FIIATVVGVLL---FLIIVVVIGIL-IKRRRQKIRKYTM--------RRLL EGFR_Mmus KI-P-----SIATGIVGGLL---FIVVVALGIGL-FMRRRHIVRKRTL--------RRLL let-23_Cele KT-R----MVIIGSVLFGFA---VMFLFI--LLV-YWRCQRIGKKLKI--------AEMV ErbB4_Hsap RT-P-----LIAAGVIGGLF---ILVIVGLTFAV-YVRRKSIKKKRAL--------RRFL ErbB3_Hsap KT-H----LTMALTVIAGLV---VIFMMLGGTFL-YWRGRRIQNKRAM--------RRYL ErbB2_Hsap PL-T-----SIISAVVGILL---VVVLGVVFGIL-IKRRQQKIRKYTM--------RRLL EGFR_Hsap KI-P-----SIATGMVGALL---LLLVVALGIGL-FMRRRHIVRKRTL--------RRLL EGFR_Spur MS------IGLLAGIVTSSL---IIFIVIIVFVI-WF-KQRIKNDMYIDIPPNIDLHDMK AqueK263_Aque xxxx----xxxxxx-----xxxxxxxxxxxxxxxxxxxxxxxxxxxxx------------ AqueK264_Aque IVSI----EAVIGSIFGGLTLITLTVLVILILVLFLLRKNRK--SIYI------------ AqueK265_Aque GT-T----GVVIGSALGGLLLTALVILIIVMLLVFVPRALRKKNKYNL--------NEVF AqueK266_Aque ------------------------------------------------------------ Egfr_Dmel SGCED----------------SEPLRPSNIGANLCKLRIVKDAELR--KGGVLGMGAFGR ErbB4_Mmus -ETEL----------------VEPLTPSGTAPNQAQLRILKETELK--RVKVLGSGAFGT ErbB3_Mmus ERGES----------------IEPLDPSE-KANKVLARIFKETELR--KLKVLGSGVFGT ErbB2_Mmus QETEL----------------VEPLTPSGAVPNQAQMRILKETELR--KLKVLGSGAFGT EGFR_Mmus QEREL----------------VEPLTPSGEAPNQAHLRILKETEFK--KIKVLGSGAFGT let-23_Cele DMPE-----------------LTPIDAS-VRPNMSRICLIPSSELQTKLDKKLGAGAFGT ErbB4_Hsap -ETEL----------------VEPLTPSGTAPNQAQLRILKETELK--RVKVLGSGAFGT ErbB3_Hsap ERGES----------------IEPLDPSE-KANKVLARIFKETELR--KLKVLGSGVFGT ErbB2_Hsap QETEL----------------VEPLTPSGAMPNQAQMRILKETELR--KVKVLGSGAFGT EGFR_Hsap QEREL----------------VEPLTPSGEAPNQALLRILKETEFK--KIKVLGSGAFGT EGFR_Spur SCDYT----------------GAPLTPSNVEPNQAQLKIIKDTELK--LGPVLGSGAFGT AqueK263_Aque x--------------xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx--xxxxxxxxxxxx AqueK264_Aque AELELCNEVCIFKTYSFISYYVNIETPxKVPPDATKLILIPETELE--FKKELGSGAFGT AqueK265_Aque SSPEELELF---------TLGKETLQPPRMAPNATRLIVAPEDELE--FGKELGAGAFGT AqueK266_Aque ------------------------------------------------------------ Egfr_Dmel VYKGVWVPE-GENVK-IPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMS ErbB4_Mmus VYKGIWVPE-GETVK-IPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLS ErbB3_Mmus VHKGIWIPE-GESIK-IPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCPG ErbB2_Mmus VYKGIWIPD-GENVK-IPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLT EGFR_Mmus VYKGLWIPE-GEKVK-IPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLT let-23_Cele VFAGIYYPKRAKNVK-IPVAIKVFQT--DQSQTDEMLEEATNMFRLRHDNLLKIIGFCMH ErbB4_Hsap VYKGIWVPE-GETVK-IPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLS ErbB3_Hsap VHKGVWIPE-GESIK-IPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPG ErbB2_Hsap VYKGIWIPD-GENVK-IPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLT EGFR_Hsap VYKGLWIPE-GEKVK-IPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLT EGFR_Spur VYKGLWIPD-GEKIR-IPVAIKALREV-SPHAAEELLEEAKVMASVDHPCLLRLLCVCIA AqueK263_Aque xx-xxxxxx-xxxxxxxxxxxxxxxx-xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx AqueK264_Aque VYEGYWKPD-NDEAE-YHVAIKILKN-TSADASKELLQEGVVMATx-------------- AqueK265_Aque VYEGYWKPA-NDENE-YHVAIKVLKN-TSASASKELLQEGVVMATMDHENVVRLYCVCMS AqueK266_Aque ---ILLNLN-GEQIKC------QRNV-TC------------------------------- Egfr_Dmel S-QMMLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARN ErbB4_Mmus P-TIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARN ErbB3_Mmus S-SLQLVTQYLPLGSLLDHVRQHRETLGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRN ErbB2_Mmus S-TVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARN EGFR_Mmus S-TVQLITQLMPYGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARN let-23_Cele DDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRN ErbB4_Hsap P-TIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARN ErbB3_Hsap S-SLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARN ErbB2_Hsap S-TVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARN EGFR_Hsap S-TVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARN EGFR_Spur Q-NMTLITQLMPLGAILDYVRQHKEQIGSHHLLNWSFQIAKGMVYLEEKHLIHRDLAARN AqueK263_Aque x-xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxLVHRDLAARN AqueK264_Aque -------------------xxxHRNSISAQTVINFSLQIAKGMAYLESKSLVHRDLAARN AqueK265_Aque K-QLMLVSQFVPCGALIDYIKKQQDRLNAHTILLFSSQIANGMAYLETKHLVHRDLAARN AqueK266_Aque -----------PSGYYREQ-------------------------LLED------------ Egfr_Dmel VLVQTPSLVKITDFGLAKLLSSDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGV ErbB4_Mmus VLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGV ErbB3_Mmus VMLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKYTHQSDVWSYGV ErbB2_Mmus VLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGV EGFR_Mmus VLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGV let-23_Cele VLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGV ErbB4_Hsap VLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGV ErbB3_Hsap VLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGV ErbB2_Hsap VLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGV EGFR_Hsap VLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGV EGFR_Spur VLVQSPAQVKITDFGLAKFLEVDSNEYKAQ----------------------------GV AqueK263_Aque ALVQSHLKVLITDFGLTRFIEPDESHYEASGSKLPVRWLPPESIRQRIFTHKTDIWSFGV AqueK264_Aque VLVQSHLKVLITDFGLTRFIEPDESHYEAPGSKLPVRWLPPESIQQRIFTHKTDVWSFGV AqueK265_Aque VLVQTPVKVKITDFGLTRIIEANQSHYEATTSKMPVRWLPPESIRNRVFTHKTDVWSFGV AqueK266_Aque ------------------------------------------------------------ Egfr_Dmel TIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFK ErbB4_Mmus TIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFK ErbB3_Mmus TVWELMTFGAEPYAGLRLAEIPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFK ErbB2_Mmus TVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFR EGFR_Mmus TVWELMTFGSKPYDGIPASDISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFR let-23_Cele TCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFE ErbB4_Hsap TIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFK ErbB3_Hsap TVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFK ErbB2_Hsap TVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFR EGFR_Hsap TVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFR EGFR_Spur TLWELMTFGGKPYEGVKAREVPELLERGERLPQPPICTIDIYMLMVKCWLIDEDSRPTFK AqueK263_Aque TVWEILTFGESPFKGKSVFELLKLLEKGDRLKQPKTCTLVFYKSLQNCWELEPEKRPSFE AqueK264_Aque TVWEILTFGESPFKGKSVFELLKLLEKGDRLKQPKTCTLEFYKTLQNCWELEPERRPSFE AqueK265_Aque TVWEILTFGARPYQGKKPYEILKMLEGGHRLDQPVTCTIDLYAVLLECWLLEPDSRPDFV AqueK266_Aque -----------------------------------------RGIFLTGWELEPERRPSFE : * : ** * Egfr_Dmel QLTTVFAEFARDPGRYLAIPGDKFTRL-------PAYTSQDEKDLIRKLAPTTDGS---E ErbB4_Mmus ELAAEFSRMARDPQRYLVIQGDDRMKL-------PSPN---DSKFFQNLLDEEDL----E ErbB3_Mmus ELANEFTRMARDPPRYLVIKRASGPGIP------PAAE---PSALSTKELQDAEL----E ErbB2_Mmus ELVSEFSRMARDPQRFVVIQNED-LGP-------SSPM---DSTFYRSLLEDDDM----G EGFR_Mmus ELILEFSKMARDPQRYLVIQGDERMHL-------PSPT---DSNFYRALMDEEDM----E let-23_Cele ILYERFKEFCKVPQLFLENSNK--ISES------D---LSAEERFQTERIR-----EMFD ErbB4_Hsap ELAAEFSRMARDPQRYLVIQGDDRMKL-------PSPN---DSKFFQNLLDEEDL----E ErbB3_Hsap ELANEFTRMARDPPRYLVIKRESGPGIA------PGPE---PHGLTNKKLEEVEL----E ErbB2_Hsap ELVSEFSRMARDPQRFVVIQNED-LGP-------ASPL---DSTFYRSLLEDDDM----G EGFR_Hsap ELIIEFSKMARDPQRYLVIQGDERMHL-------PSPT---DSNFYRALMDEEDM----D EGFR_Spur QMQEELERMTKDPQRYLVIQNDGAMSL-------PSPT---PSDFYKTLMQDTESGADPD AqueK263_Aque DLVYQFNTMMMSPKKYVKIKKTRALRGTVYTSHDGNNK---ESNFHKRRNEDTGNV---- AqueK264_Aque DLVYQFNTMMMSPKKYEDSNDKD------------------------------------- AqueK265_Aque DLGRRFHEFMNDPARYVLTVVSM------------------------------------- AqueK266_Aque DLVYQFNTMMMSPKKYVKIKKTRALRGAVYDSHDSNKK---ESNFHKGRLKDTHKN---- : : : * : Egfr_Dmel AIAEPDDYLQPKAA--P---------GPSHRTD--------------------------- ErbB4_Mmus DMMDAEEYLVPQAFNIP---------PPIY-TSRTRIDSNRSEIGHSPPPAYTPMSGNQF ErbB3_Mmus PDLDLDLDVEVEEEGLATT-LGSALSLPTG-T-LTRPR--GSQSLLSPSSGYMPMNQSNL ErbB2_Mmus ELVDAEEYLVPQQGFFSP--------DPALGTGSTAHRRHRSSSA--------------- EGFR_Mmus DVVDADEYLIPQQGFFN---------SPS--TSRTPLLSS-------------------- let-23_Cele GNIDPQMYFDQ--GSLPS--------MP-------------------------------- ErbB4_Hsap DMMDAEEYLVPQAFNIP---------PPIY-TSRARIDSNRSEIGHSPPPAYTPMSGNQF ErbB3_Hsap PELDLDLDLEAEEDNLATTTLGSALSLPVG-T-LNRPR--GSQSLLSPSSGYMPMNQGNL ErbB2_Hsap DLVDAEEYLVPQQGFFCP--------DPAPGAGGMVHHRHRSSST--------------- EGFR_Hsap DVVDADEYLIPQQGFFS---------SPS--TSRTPLLSS-------------------- EGFR_Spur LLMDAEDYLQPMSLTA-------------------------------------------- AqueK263_Aque ---------D-------------------------------------------------- AqueK264_Aque ------GYVDCLQENFN---------DK---------------------DGYVD------ AqueK265_Aque ------SVC--------------------------------------------------- AqueK266_Aque -SNDKDGYVDCLHEDSN---------DK---------------------DGYVD------ Egfr_Dmel ------------------------------------------------------------ ErbB4_Mmus VYQ------DGGFA---TQQ-GMPMPYRATTSTIPEAPVAQGATAEMFDDSCCNGTLRKP ErbB3_Mmus GEACLDSAVLGGREQFSRPISLHPIPRGRQTSESSEGHV-TGSEAELQERVSMCRSRSRS ErbB2_Mmus --R------SGGGE---LTL-GLE-PSEEEPPRSPLAP-SEGAGSDVFDGDLAVGVTKGL EGFR_Mmus ----------------------------------------LSATSN--NSTVACINRN-- let-23_Cele -----------------------------------SSP-TSMATFTIPHGDLMNR----- ErbB4_Hsap VYR------DGGFA---AEQ-GVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRKP ErbB3_Hsap GESCQESAVSGSSERCPRPVSLHPMPRGCLASESSEGHV-TGSEAELQEKVSMCRSRSRS ErbB2_Hsap --R------SGGGD---LTL-GLE-PSEEEAPRSPLAP-SEGAGSDVFDGDLGMGAAKGL EGFR_Hsap ----------------------------------------LSATSN--NSTVACIDRNGL EGFR_Spur ---------------------------------------------N--NMTY-------- AqueK263_Aque ---------------------------------------CLHEDS--NDK-------DGY AqueK264_Aque ------------------------------------------------------------ AqueK265_Aque ------------------------------------------------------------ AqueK266_Aque ---------------------------------------CLHEDS--NDK-------DGY Egfr_Dmel ---CTDEIPK--LNRYCKD-PSNKNSSTGDDETDSSAREVGVGNLRLDLPVDEDDYLMPT ErbB4_Mmus VAPHVQEDSS--TQRYSAD-PTVFAPERNP-----------------RGELDEEGYMTPM ErbB3_Mmus RSPRPRGDSAYHSQRHSLLTPVTPLSPP-G-----------------LEEEDGNGYVMPD ErbB2_Mmus QSLSPHDLSP--LQRYSED-PTLPLP------------------------PETDGYVAPL EGFR_Mmus GSCRVKEDAF--LQRYSSD-PTGAVTEDN----------------------IDDAF---- let-23_Cele -----MQSVN--SSRYKTE-PFDYGST----------------------AQEDNSYLIPK ErbB4_Hsap VAPHVQEDSS--TQRYSAD-PTVFAPERSP-----------------RGELDEEGYMTPM ErbB3_Hsap RSPRPRGDSAYHSQRHSLLTPVTPLSPP-G-----------------LEEEDVNGYVMPD ErbB2_Hsap QSLPTHDPSP--LQRYSED-PTVPLP------------------------SETDGYVAPL EGFR_Hsap QSCPIKEDSF--LQRYSSD-PTGALTEDS----------------------IDDTF---- EGFR_Spur --------------------------------------------------ESQQGFF--- AqueK263_Aque V-DCLQEDS--------N---------------------------------DKDGYVD-- AqueK264_Aque --------------------------CLQ------------------EDFNDKDGYVDCL AqueK265_Aque ------------------------------------------------------------ AqueK266_Aque V-DCLHEDS--------ND-KDGYVDCLH------------------EDSNDKDGYVECL Egfr_Dmel C---------------------------Q--PGPN------------------------- ErbB4_Mmus H--------------------------DK--PKQEYLNPVEEN-PFVSRRKNGDLQA--- ErbB3_Mmus THLRGTSSSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRKRRGSPARPPRP-GSLEELGY ErbB2_Mmus A--------------------------CS--PQPEYVNQPEVR-PQSPLTPEGPPPP--- EGFR_Mmus ----------------------------L--PVPEYVNQS------VPKRPAGSV----- let-23_Cele TKEV-------------QQSAVLYTAVTNEDGQTE--------------------LS--- ErbB4_Hsap R--------------------------DK--PKQEYLNPVEEN-PFVSRRKNGDLQA--- ErbB3_Hsap THLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRRRRHSPPHPPRP-SSLEELGY ErbB2_Hsap T--------------------------CS--PQPEYVNQPDVR-PQPPSPREGPLPA--- EGFR_Hsap ----------------------------L--PVPEYINQS------VPKRPAGSV----- EGFR_Spur ------------------------------------------------------------ AqueK263_Aque --------------------------------------CLHED----------------- AqueK264_Aque Q--------------------------ED--SNDGYV----------------------- AqueK265_Aque ------------------------------------------------------------ AqueK266_Aque H--------------------------EDSNDKDSYIDCLHED----------------- Egfr_Dmel -------------------------------------NNNNINNPNQNNM------AAV- ErbB4_Mmus ---------------LDNP--EYHSASSGP----PKAEDEYVN----------------- ErbB3_Mmus EYMDVGSDLSASLGSTQSC--PLHPMAIVPSAGTTPDEDYEYMNRRRGAGGSGGDYAAMG ErbB2_Mmus ---------------I-RPAGATLERPKTL----SPGKNGVVK----------------- EGFR_Mmus ----------------QNP--VYHNQPLHP----APGRDLHYQ----------------- let-23_Cele ---------------PSNG--DYYNQPNTP----S-SSSGYYNEPHLKT----------- ErbB4_Hsap ---------------LDNP--EYHNASNGP----PKAEDEYVN----------------- ErbB3_Hsap EYMDVGSDLSASLGSTQSC--PLHPVPIMPTAGTTPDEDYEYMNRQRDGGGPGGDYAAMG ErbB2_Hsap ---------------A-RPAGATLERPKTL----SPGKNGVVK----------------- EGFR_Hsap ----------------QNP--VYHNQPLNP----APSRDPHYQ----------------- EGFR_Spur ------------------------------------------------------------ AqueK263_Aque ------------------------------------------------S----------- AqueK264_Aque ------------------------------------------------------------ AqueK265_Aque ------------------------------------------------------------ AqueK266_Aque ------------------------------------------------A----------- Egfr_Dmel ---GVAAGYMDL---IGVPVSVDNPEYLLNAQTLGVGESPIPTQTIGIPVMGVPGTMEVK ErbB4_Mmus ----------EPLYLNTFANALGSAEYMKNS-------VL-------------------- ErbB3_Mmus ACPAAEQGYEEMRAFQGPGHQAPHVRYARLK-------TL-------------------- ErbB2_Mmus ----------DV---FAFGGAVENPEYLAPRAGT--ASQP-------------------- EGFR_Mmus ---------------NPHSNAVGNPEYLNT------------------------------ let-23_Cele ------------------------------------------------------------ ErbB4_Hsap ----------EPLYLNTFANTLGKAEYLKNN-------IL-------------------- ErbB3_Hsap ACPASEQGYEEMRAFQGPGHQAPHVHYARLK-------TL-------------------- ErbB2_Hsap ----------DV---FAFGGAVENPEYLTPQGGA--APQP-------------------- EGFR_Hsap ---------------DPHSTAVGNPEYLNT------------------------------ EGFR_Spur ------------------------------------------------------------ AqueK263_Aque ---------------------DDNDGYVDCLQ---------------------------- AqueK264_Aque ------------------------------------------------------------ AqueK265_Aque ------------------------------------------------------------ AqueK266_Aque ---------------------NDKDGYIDCLQ---------------------------- Egfr_Dmel VPMPGSEPTSSDHEYYNDTQR------------E------LQP----------------- ErbB4_Mmus SVPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIR-P-IVAENPEYL ErbB3_Mmus RSLEATDSAFDNPDYWHSRLFP-------------------------------------- ErbB2_Mmus HPSPAFSPAFDNLYYWDQNSSEQ-----------------GPPPSTFE-GTPTAENPEYL EGFR_Mmus AQPTCLSSGFNSPALWIQKGSHQMSLDNPDYQQDFFPKE-TKPNGIFK-G-PTAENAEYL let-23_Cele ----------------------------------------KKPETSEEAEAVQYENEE-- ErbB4_Hsap SMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIR-P-IVAENPEYL ErbB3_Hsap RSLEATDSAFDNPDYWHSRLFP-------------------------------------- ErbB2_Hsap HPPPAFSPAFDNLYYWDQDPPER-----------------GAPPSTFK-GTPTAENPEYL EGFR_Hsap VQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKE-AKPNGIFK-G-STAENAEYL EGFR_Spur ------------------------------------------------------------ AqueK263_Aque ------------------EDS----ND-KDGYVDCFD----------E-GANDA------ AqueK264_Aque ---------------------------------DCFN----------E-GPNDA------ AqueK265_Aque ------------------------------------------------------------ AqueK266_Aque ------------------EDS-------NDGDIDCFN----------E-GANDA------ Egfr_Dmel -L-----------HRNRNTETRV ErbB4_Mmus SEFSLKPGTMLPPPPYRHRNTVV ErbB3_Mmus ----------------KANAQRI ErbB2_Mmus -----------------GLDVPV EGFR_Mmus RV-----------APPSSEFIGA let-23_Cele ---------------VSQKETCL ErbB4_Hsap SEFSLKPGTVLPPPPYRHRNTVV ErbB3_Hsap ----------------KANAQRT ErbB2_Hsap -----------------GLDVPV EGFR_Hsap RV-----------APQSSEFIGA EGFR_Spur -------------PVVSHYWIGR AqueK263_Aque -V-----------IMKTLATSIA AqueK264_Aque -I-----------VTKTLATSIA AqueK265_Aque -V-----------CVGVCELYHV AqueK266_Aque -V-----------IMKTLATSIV