CLUSTAL W (1.83) multiple sequence alignment TYK2_Hsap MPLRHW--------G---M-------ARGSKP-VGDGAQPM--AAM-GGLKVLL-HWAGP JAK3_Hsap MAPPS---------E--ETPL----------I-PQRSCSLL--STEAGALHVL-LPARGP JAK2_Hsap MGMACLTMTEMEGTS--TSSI-----YQNGDI-SGNANSMK--QID-PVLQVYLYHSLGK JAK1_Hsap MQYLNIKED-CNAMA--FC-------AKMRSS-KKTEVNLE--APE-PGVEVIF-YLS-- hop_Dmel MALANGGEDRMDDSSSGRTSLADSASLTNSSLRSGTSSQSI--HTNDGTIRVFN-FTT-- JAK3_Mmus MAPPS---------E--ETPL----------I-PQRSCSLS--SSEAGALHVL-LPPRGP JAK2_Mmus MGMACLTMTEMEATS--TSPV-----HQNGDI-PGSANSVK--QIE-PVLQVYLYHSLGQ JAK1_Mmus MQYLNIKED-CNAMA--FC-------AKMRSF-KKTEVKQV--VPE-PGVEVTF-YLL-- TYK2_Mmus MVGTMPL---CGRRA---I-------LEDSKA-DGTEAQPL--VPT-GCLMVLL-HWPGP JAK1_Spur MIKNTVSP-----------PN------GSGLG-EG------------------------- JAK2_Spur MTQKVSIRHMVNM-------------LRLPSIRSSRESPGLPNGMEPDIVEVRT-YMC-- * TYK2_Hsap GGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPN-HILE---- JAK3_Hsap GPPQ-RLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPS-HIFS---- JAK2_Hsap SEAD-YLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPN-HVFH---- JAK1_Hsap -DRE-PLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPN-RTIT---- hop_Dmel --GEF-ERF-HPNMLCEEICNTMCRQLGIAPIAQLLYGIREHSTSRRPSPLVRLDLTWCL JAK3_Mmus GPPQ-RLSFSFGDYLAEDLCVRAAKACGILPVYHSLFALATEDFSCWFPPS-HIFC---- JAK2_Mmus AEGE-YLKFPSGEYVAEEICVAASKACGITPVYHNMFALMSETERIWYPPN-HVFH---- JAK1_Mmus -DRE-PLRLGSGEYTAEELCIRAAQECSISPLCHNLFALYDESTKLWYAPN-RIIT---- TYK2_Mmus EGGEPWVTFSQTSLTAEEVCIHIAHKVGITPPCLNLFALYNAQAKVWLPPN-HILD---- JAK1_Spur ------------------------------------------------------------ JAK2_Spur --GNLVLPW-RERLTVEQVCIKAAKLCGIPRLTSNLFALYDKTNKKWLCPKAQVFS---- TYK2_Hsap -IP-RDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEAS--SDQTAQGMQLLDPAS JAK3_Hsap -VE-DASTQVLLYRIRFYFPNWFGLE----KCHRFGLR----------KDLASAILDLPV JAK2_Hsap -ID-ESTRHNVLYRIRFYFPRWYCSGSN--RAYRHGIS----------RGAEAPLLDDFV JAK1_Hsap -VD-DKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASS hop_Dmel PGERLNCQLVYCFRMRFRVPEL---------------------------DSQLELIDGRS JAK3_Mmus -IE-DVDTQVLVYRLRFYFPDWFGLE----TCHRFGLR----------KDLTSAILDLHV JAK2_Mmus -ID-ESTRHDILYRIRFYFPHWYCSGSS--RTYRYGVS----------RGAEAPLLDDFV JAK1_Mmus -VD-DKTSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKRVPEATPLLDASS TYK2_Mmus ----TSQDMNLYFRMRFYFRNWHGMNPQEPAVYRCGFPGAETS--SDRAEQGVQLLDSAS JAK1_Spur ------------------------------------------------------------ JAK2_Spur -RR-QRKSEQLEYRVRFHTATMCPSGD----------------------AQGFMLLEENV TYK2_Hsap FEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVA-K JAK3_Hsap LEHLFAQHRSDLVSGRLPVGLS------LKEQGECLSLAVLDLARMAREQAQRPGELL-K JAK2_Hsap MSYLFAQWRHDFVHGWIKVPVT------HETQEECLGMAVLDMMRIAKENDQTPLAIY-N JAK1_Hsap LEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELP-K hop_Dmel HKFLYRQMRYDMRTEQIPEIRY------PEHKDKSTGLAVMDMLIDDQEQSEDQQAMRSI JAK3_Mmus LEHLFAQHRSDLVSGRLPVGLS------MKEQGEFLSLAVLDLAQMAREQAQRPGELL-K JAK2_Mmus MSYLFVQWRHDFVHGWIKVPVT------HETQEECLGMAVLDMMRIAKEKDQTPLAVY-N JAK1_Mmus LEYLFAQGQYDLIKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELP-K TYK2_Mmus FEYLFEQGKHEFMNDVVSLRDLSSEEEIHHFKNESLGMAFLHLCHLALSRGVPLEEMA-R JAK1_Spur ------------------------------------------------------------ JAK2_Spur VNYMFCQYRESFLNDEFMG---------L-STEESLGLMVLDFMQHVKEDGTSLTNLN-G TYK2_Hsap KTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQ-----PGRLSQQMVMVKYLAT JAK3_Hsap TVSYKACLPPSLRDLIQGLSFVTRRRIRRTVRRALRRVA-----ACQADRHSLMAKYIMD JAK2_Hsap SISYKTFLPKCIRAKIQDYHILTRKRIRYRFRRFIQQFS-----QCKATARNLKLKYLIN JAK1_Hsap DISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLAT hop_Dmel EKLYKLYLPPSLWR---AHSFFVGSKIREVFRS----LK-----ANSLSVERLKWHYVHQ JAK3_Mmus TVSYKACLPPSLRDVIQGQNFVTRRRIRRTVVLALRRVV-----ACQADRYALMAKYILD JAK2_Mmus SVSYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIQQFS-----QCKATARNLKLKYLIN JAK1_Mmus DISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLAT TYK2_Mmus EISFKNCIPHSFRQHIRQHNVLTRLRLHRVFRRFLRAFR-----PGHLSQQVVMVKYLAT JAK1_Spur ------------------------------------------------------------ JAK2_Spur RLRFGRFLPKSLNE---GLSWWDKRKLRRKVRTALTDFR-----DDPRETFAFRVMFLVS TYK2_Hsap L-ERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDP----GPESAAGP-PT-HE JAK3_Hsap L-ERLDPAGAAETFHVGLPGA------------L-----------------GGH-DGLGL JAK2_Hsap L-ETLQSAFYTEKFEVKEPGS-----------GP-----------------SGE-EIFAT JAK1_Hsap L-ETLTKHYGAEIFETSMLLISSENEMNWFHSND-----------------GGN-VLYYE hop_Dmel V-SHLAPTYMTEQFTCTVQYLPN-EEVAR-GSGPIGTSLAHSTSTLA---SSGSTNTL-S JAK3_Mmus L-ERLHPAATTETFRVGLPGA--------------------------------Q-EEPGL JAK2_Mmus L-ETLQSAFYTEQFEVKESAR-----------GP-----------------SGE-EIFAT JAK1_Mmus L-ETLTKHYGAEIFETSMLLISSENELSRCHSND-----------------SGN-VL-YE TYK2_Mmus L-ERLAPRFGSERIPVCHLEVLAQPERDPCYIQNSGQTAGDP----GPELPSGP-PT-HE JAK1_Spur ------------------GGS-----------GP-----------------GGS-G---- JAK2_Spur LSEEMKQEWGTEQFTMANGDIY---E----VSGVKG------------------------ TYK2_Hsap VLVTGTGGIQWWPVEEEVN--KEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPL JAK3_Hsap LRVAGDGGIAWTQGE------------------------------------------QEV JAK2_Hsap IIITGNGGIQWSRGKH--------------------------------KE--SETLTEQD JAK1_Hsap VMVTGNLGIQWRHKPNVVSVEKEKNK--L---------KRKKLE-NKHKKDEEKNKIREE hop_Dmel TLTTNTNSVALGG-------------------------SGK-----KAKR--RSTSGGID JAK3_Mmus LRVAGDNGISWSSGD------------------------------------------QEL JAK2_Mmus IIITGNGGIQWSRGKH--------------------------------KE--SETLTEQD JAK1_Mmus VMVTGNLGIQWRQKPNVVPVEKEKNK--L---------KRKKLEYNKHKKDDERNKLREE TYK2_Mmus VLVTGTGGIQWHPLQTQES---ERGNS---RGNPHGSRSGKKPKAPKAGEHLTESPQEPP JAK1_Spur ------------------------------------------------------------ JAK2_Spur ----------------------------------------------VTKK--KLTYGDEA TYK2_Hsap WAYFCDFR-DITHVVLKE-------------------HCVSIHRQD-----------NKC JAK3_Hsap LQPFCDFP-EIVDISIKQAPRVGPAGE---------HRLVTVTRTD-----------NQI JAK2_Hsap LQLYCDFP-NIIDVSIKQANQEG-SNE---------SRVVTIHKQD-----------GKN JAK1_Hsap WNNFSYFP-EITHIVIKE-------------------SVVSINKQD-----------NKK hop_Dmel VYVR-VFPHDSLEPGLKVARVTS-EATLKWILVGAVEGIFMISKINDTSVRLEIVGLPKG JAK3_Mmus FQTFCDFP-EIVDVSIKQAPRVGPAGE---------HRLVTVTRMD-----------GHI JAK2_Mmus VQLYCDFP-DIIDVSIKQANQEC-SNE---------SRIVTVHKQD-----------GKV JAK1_Mmus WNNFSYFP-EITHIVIKE-------------------SVVSINKQD-----------NKN TYK2_Mmus WTYFCDFQ-DISHVVLKE-------------------RRVHIHLQD-----------NKC JAK1_Spur ------------------------------------------------------------ JAK2_Spur VQDSFPFQ-DIIDITIYPSTAER-A-----------HTLLQINRRS-----------TPP TYK2_Hsap LELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQA JAK3_Hsap LEAEFPGLPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAIN JAK2_Hsap LEIELSSLREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAIS JAK1_Hsap MELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAIN hop_Dmel YEMQFQTEKEMKSFISYLGIYIRLSSKWMQDLCHSYRTPSLEELSSLHCHGPIGGAYSLM JAK3_Mmus LEAEFPGLPEALSFVALVDGYFRLICDSRHYFCKEVAPPRLLEEEAELCHGPITLDFAIH JAK2_Mmus LEIELSSLKEALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIHSNCHGPISMDFAIS JAK1_Mmus MELKLSSREEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAIN TYK2_Mmus LLLCLCSQAEALSFVALVDGYFRLTADSSHYLCHEVAPPRLVTSIQNGIHGPLMDPFVQA JAK1_Spur ------------------------------------------------------------ JAK2_Spur LILEMESRDDAESFACLLDGYYRLLVDYYHYLSETIAPPSLVRLVKNRCHGPIPLSKAKQ TYK2_Hsap KLRP---EDGLYLIHWSTSHPYRLILTVA-QRSQA-PDGMQSLRLRKFPIE-Q-QDGAFV JAK3_Hsap KLKTGGSRPGSYVLRRSPQDFDSFLLTVC-VQNPLGP------DYKGCLIRRS-PTGTFL JAK2_Hsap KLKKAGNQTGLYVLRCSPKDFNKYFLTFA-VERENVI------EYKHCLITKN-ENEEYN JAK1_Hsap KLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQ-KQFKNFQIE-V-QKGRYS hop_Dmel KLHENGDKCGSYIVRECDREYNIYYIDIN-TKIMAKKTDQERCKTETFRIVRKDSQWKLS JAK3_Mmus KLKAAGSLPGTYILRRSPQDYDSFLLTAC-VQTPLGP------DYKGCLIRQD-PSGAFS JAK2_Mmus KLKKAGNQTGLYVLRCSPKDFNKYFLTFA-VERENVI------EYKHCLITKN-ENGEYN JAK1_Mmus KLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEVLG-GQ-KQFKNFQIE-V-QKGRYS TYK2_Mmus KLWP---EDGLYLIQWSTSHLHRLILTVA-HRNPAFSNGPRGLRLRKFPIT-Q-QPGAFV JAK1_Spur ------------------------------------------------------------ JAK2_Spur KIEETGRQEGVYLIRQNPEDHYSYCLTVR-IHANQ---ELK-----NFKINCY-EDDDQV TYK2_Hsap LEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGAR-A--S-- JAK3_Hsap LVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGH-S--PPT JAK2_Hsap LSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVS--DVP JAK1_Hsap LHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQE--W-- hop_Dmel YNNGEHVLNSLHEVAHIIQADSPDRY----RIPASKYDKPPLLL-LLLPKNLKAKKTDLQ JAK3_Mmus LVGLSQPHRSLRELLAACWNSGLRVDGAALNLTSCCAPRPKEKSNLIVVRRGC-T--PAP JAK2_Mmus LSGTKRNFSNLKDLLNCYQMETVRSDSIIFQFTKCCPPKPKDKSNLLVFRTNGIS--DVQ JAK1_Mmus LHGSMDHFPSLRDLMNHLKKQILRTDNISFVLKRCCQPKPREISNLLVATKKAQE--W-- TYK2_Mmus LDGWGRSFASLGDLRLALQGCSLRAGDDCFPLHHCCLPRPREISNLVIMRGSR-A--H-- JAK1_Spur ------------------------------------------------------------ JAK2_Spur GLDNQRRFNCLRSFVEFYRSR-ENSWCLEGQLRKGVPIEPKDPALRILDRSALNV--DLP TYK2_Hsap ------PRTLNLSQLSFHRVDQKEITQLS-HLGQGTRTNVYEGRLRVEGSGDPEEGKMDD JAK3_Hsap SSLVQPQSQYQLSQMTFHKIPADSLEWHE-NLGHGSFTKIYRGCRHEVVD---------- JAK2_Hsap TSPT-LQRPTHMNQMVFHKIRNEDLIFNE-SLGQGTFTKIFKGVRREVGD-Y-------- JAK1_Hsap ------QPVYPMSQLSFDRILKKDLVQGE-HLGRGTRTHIYSGTLMDYKDDE-------- hop_Dmel LSE---AELQRRNPQIFN--PRTDLQWYPDSISLSDDGMMF-TMRGDWIQ---------- JAK3_Mmus APGCS-PSCCALTQLSFHTIPTDSLEWHE-NLGHGSFTKIFRGRRREVVD---------- JAK2_Mmus ISPT-LQRHNNVNQMVFHKIRNEDLIFNE-SLGQGTFTKIFKGVRREVGD-Y-------- JAK1_Mmus ------QPVYSMSQLSFDRILKKDIIQGE-HLGRGTRTHIYSGTLLDYKDEE-------- TYK2_Mmus ------TRPLNLSQLSFHRVHQDEITQLS-HLGQGTRTNVYEGLLRVGGPDE---GKVDN JAK1_Spur ---------------------------------------------------E-------- JAK2_Spur SQPE-TGPIRWIQE---N--NLSSRTNWR-HLDDGDFTEVWAADLRKKVG---------- TYK2_Hsap EDPLVPGRDRGQELRV-VLKV--LDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRG JAK3_Hsap --------GEARKTEV-LLKV--MDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAG JAK2_Hsap --------GQLHETEV-LLKV--LDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCG JAK1_Hsap ------GTSEEKKIKV-ILKV--LDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRD hop_Dmel -------QSPVKDVSV-TMKM--LKS-DGNFM-EFFRLAQTWSLIQSPQFLKLYGLTLAD JAK3_Mmus --------GETHDSEV-LLKV--MDSRHRNCMESFLEAASLMSQVSYPHLVLLHGVCMAG JAK2_Mmus --------GQLHKTEV-LLKV--LDKAHRNYSESFFEAASMMSQLSHKHLVLNYGVCVCG JAK1_Mmus ------GIAEEKKIKV-ILKV--LDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRD TYK2_Mmus GCPPEPGGTSGQQLRV-VLKV--LDPSHHDIALAFYETASLMSQVSHMHLAFLHGVCVRG JAK1_Spur ------GATGGASILVEIESV--LNPTEEDDIL--------------------------- JAK2_Spur --------NRPRKMRV-AIKCPKMDA-PQSVQQKFSQSVDLMSSWVHKHIIRFEGIGA-- . * . :. . TYK2_Hsap PENIMVTEYVEHGPLDVWLRR----ERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVC JAK3_Hsap -DSTMVQEFVHLGAIDMYLRK----RGHLVPASWKLQVVKQLAYALNYLEDKGLPHGNVS JAK2_Hsap DENILVQEFVKFGSLDTYLKK----NKNCINILWKLEVAKQLAWAMHFLEENTLIHGNVC JAK1_Hsap VENIMVEEFVEGGPLDLFMHR----KSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVC hop_Dmel -PYTMVMEYSRYGPLNKFLHS----MPN-VTLHCLLDLMHGLVRGMHYLEDNKIIHNYIR JAK3_Mmus -DSIMVQEFVYLGAIDMYLRK----RGHLVSASWKLQVTKQLAYALNYLEDKGLPHGNVS JAK2_Mmus EENILVQEFVKFGSLDTYLKK----NKNSINILWKLGVAKQLAWAMHFLEEKSLIHGNVC JAK1_Mmus VENIMVEEFVEGGPLDLFMHR----KSDALTTPWKFKVAKQLASALSYLEDKDLVHGNVC TYK2_Mmus SENIIVTEFVEHGPLDVWLRR----QRGQVPMTWKMVVAQQLASALSYLEDKNLVHGNVC JAK1_Spur ------------------------------------------------------------ JAK2_Spur -GYMLVMEYASEGPLDHYLRSLLENERKRLGLNSQLHAAFQLIDALEYLESRRIVHGNVS TYK2_Hsap GRNILLARLGL-AEGTSPFIKLSDPGVGLGALSREE----RVERIPWLAPECLPGGAN-- JAK3_Hsap ARKVLLAREGA--DGSPPFIKLSDPGVSPAVLSLEM----LTDRIPWVAPECLRE-AQ-- JAK2_Hsap AKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDI----LQERIPWVPPECIEN-PK-- JAK1_Hsap TKNLLLAREGI-DSECGPFIKLSDPGIPITVLSRQE----CIERIPWIAPECVED-SK-- hop_Dmel CSNLYVTKYDP-N-SYVLDAKISDPGYP-----RPY----RESDSPWIPVKYYRN-LQAA JAK3_Mmus ARKVLLAREGG--DGNPPFIKLSDPGVSPTVLSLEM----LTDRIPWVAPECLQE-AQ-- JAK2_Mmus AKNILLIREEDRRTGNPPFIKLSDPGISITVLPKDI----LQERIPWVPPECIEN-PK-- JAK1_Mmus TKNLLLAREGI-DSDIGPFIKLSDPGIPVSVLTRQE----CIERIPWIAPECVED-SK-- TYK2_Mmus GRNILLARLGL-EEGTNPFIKLSDPGVGQGALSREE----RVERIPWTAPECLSGGTS-- JAK1_Spur ------------------------------------------------------------ JAK2_Spur AHNTLVLRPAP-N----MHIKLADPMLGVYYHSLEMTSRPKLERVRWTAPELLAT-NS-- TYK2_Hsap SLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPS-C-PQLATLTSQ JAK3_Hsap TLSLEADKWGFGATVWEVFSGVTMPISALDPAKKLQFYEDRQQLPAPK-W-TELALLIQQ JAK2_Hsap NLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPK-W-AELANLINN JAK1_Hsap NLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPS-C-KELADLMTR hop_Dmel KTDQFAQLWAFATTIYEIFSRCKEDLSTLRQEQLLR------------Q-K-NLDGNILK JAK3_Mmus TLGLEADKWGFGATTWEVFSGGPAHITSLEPAKKLKFYEDQGQLPALK-W-TELAGLITQ JAK2_Mmus NLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDKHQLPAPK-W-TELANLINN JAK1_Mmus NLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPS-C-KELADLMTR TYK2_Mmus SLGTATDMWGFGATLLEICFDGEAPLQGRGPSEKERFYTKKHQLPEPS-S-PELATLTRQ JAK1_Spur ------------------------------------------------------------ JAK2_Spur EPTLAGDKFSYAITLWQIMSHGAIPAENLSDExxxxxYRHGVRLDAPPGCPQELLKIMEA TYK2_Hsap CLTYEPTQ-----------------RPSFRTILRDLTRLQPHNLADVLTVNPDS------ JAK3_Hsap CMAYEPVQ-----------------RPSFRAVIRDLNSLISSDYE-LLSDPTPGALAPRD JAK2_Hsap CMDYEPDF-----------------RPSFRAIIRDLNSLFTPDYE-LLTENDM-LPNMRI JAK1_Hsap CMNYDPNQ-----------------RPFFRAIMRDINKLEEQNPD-IVSEKKPA------ hop_Dmel MLDQDICPAPIFETIMDGWSDDETKRFSHHDIFSRLNTIKAE----ILPNYMPP-PE--I JAK3_Mmus CMAYDPGR-----------------RPSFRAILRDLNGLITSDYE-LLSDPTPGIPSPRD JAK2_Mmus CMDYEPDF-----------------RPAFRAVIRDLNSLFTPDYE-LLTENDM-LPNMRI JAK1_Mmus CMNYDPNQ-----------------RPFFRAIMRDINKLEEQNPD-IVSEKQPT------ TYK2_Mmus CLTYEPAQ-----------------RPSFRTILRDLTRLQPQNLVGTSAVNSDS------ JAK1_Spur ----DPDE-----------------ETKFIG----------------------------- JAK2_Spur CWSHNPRN-----------------RPSCRGVLRDVNSFLSE------------------ : . TYK2_Hsap --------------------------PASDPTVFHKRYLKKI-RDLGEGHFGKVSLYCYD JAK3_Hsap GLWNGA-----------------QLYACQDPTIFEERHLKYI-SQLGKGNFGSVELCRYD JAK2_Hsap GALGFS-----------------GAFEDRDPTQFEERHLKFL-QQLGKGNFGSVEMCRYD JAK1_Hsap --------------------------TEVDPTHFEKRFLKRI-RDLGEGHFGKVELCRYD hop_Dmel ATNGTGDETVIDRSDIPFLPFPRSNMLMVIPLTSECRVIYNMENMIGRGHYGTVYKGHLE JAK3_Mmus ELCGGA-----------------QLYACQDPAIFEERHLKYI-SLLGKGNFGSVELCRYD JAK2_Mmus GALGFS-----------------GAFEDRDPTQFEERHLKFL-QQLGKGNFGSVEMCRYD JAK1_Mmus --------------------------TEVDPTHFEKRFLKRI-RDLGEGHFGKVELCRYD TYK2_Mmus --------------------------PASDPTVFHKRYLKKI-RDLGEGHFGKVSLYCYD JAK1_Spur ------------------------------VNRIPDGQLKKE-ERLGSGHFGMVFRGVLM JAK2_Spur ------FG-----------------------TLFHKQEL--------------------- : TYK2_Hsap P-TNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQL JAK3_Hsap P-LGDNTGALVAVKQLQH-SGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRL JAK2_Hsap P-LQDNTGEVVAVKKLQH-STEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKL JAK1_Hsap P-EGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKL hop_Dmel FNDKDQPREQVAIKMLNTM---QVSTDFHREIGIMRTLSHPNIVKFKYWA----EKSHCI JAK3_Mmus P-LGDNTGPLVAVKQLQH-SGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRL JAK2_Mmus P-LQDNTGEVVAVKKLQH-STEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRL JAK1_Mmus P-EGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNGIKL TYK2_Mmus P-TNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKYKGCCEDQGEKSVQL JAK1_Spur P-RQGIPAEIVA-KVIKNDSR---SDQFQQEIRAMSYCDHKNIVKVLGYCEDN-SNRLSL JAK2_Spur -------------------------------------------LKFF------------- :* TYK2_Hsap VMEYVPLGSLRDYLPRHS--IGLAQLLLFAQQICEGMAYLHAQH-YIHRDLAARNVLLDN JAK3_Hsap VMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRR-CVHRDLAARNILVES JAK2_Hsap IMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKR-YIHRDLATRNILVEN JAK1_Hsap IMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQ-YVHRDLAARNVLVES hop_Dmel IMEYLQSGSFDIYLRFTAPNLNNPRLVSFALDIANGMKYLSDMG-LIHRDLAARNILVDH JAK3_Mmus VMEYLPSGCLRDFLQRHRARLHTDRLLLFAWQICKGMEYLGARR-CVHRDLAARNILVES JAK2_Mmus IMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQICKGMEYLGTKR-YIHRDLATRNILVEN JAK1_Mmus IMEFLPSGSLKEYLPKNKNKINLKQQLKYAIQICKGMDYLGSRQ-YVHRDLAARNVLVES TYK2_Mmus VMEYVPLGSLRDYLPRHC--VGLAQLLLFAQQICEGMAYLHAQH-YIHRDLAARNVLLDN JAK1_Spur VMEYFPLGSLEKYLREKKDRVSHKTLYLFGQQICQGMKYLHEERMMVHRDLAARNVLVSN JAK2_Spur ------------------------------------------------------------ TYK2_Hsap D---RLVKIGDFGLAKAVPEGHEYYRVREDGD-SPVFWYAPECLKEYKFYYASDVWSFGV JAK3_Hsap E---AHVKIADFGLAKLLPLDKDYYVVREPGQ-SPIFWYAPESLSDNIFSRQSDVWSFGV JAK2_Hsap E---NRVKIGDFGLTKVLPQDKEYYKVKEPGE-SPIFWYAPESLTESKFSVASDVWSFGV JAK1_Hsap E---HQVKIGDFGLTKAIETDKEYYTVKDDRD-SPVFWYAPECLMQSKFYIASDVWSFGV hop_Dmel NGDGDCVKISDFGLAQFANSD-GYYYAKSKRD-IPIRWYSPEAISTCRFSSYSDVWSYGV JAK3_Mmus E---AHVKIADFGLAKLLPLGKDYYVVREPGQ-SPIFWYAPESLSDNIFSRQSDVWSFGV JAK2_Mmus E---NRVKIGDFGLTKVLPQDKEYYKVKEPGE-SPIFWYAPESLTESKFSVASDVWSFGV JAK1_Mmus E---HQVKIGDFGLTKAIETDKEYYTVKDDRD-SPVFWYAPECLIQCKFYIASDVWSFGV TYK2_Mmus D---RLVKIGDFGLAKAVPEGHEYYRVREDGD-SPVFWYAPECLKECKFYYASDVWSFGV JAK1_Spur E---NEVKITDFGLARIFGTEKDYYRAKESSQKVPIKWYAPEWLRHQKYQKESDVWSLGI JAK2_Spur ----------------------------------PVFFCAAFAMYRLY----LHVYFYNI *: : :. : .*: .: TYK2_Hsap T-LYELLTHCDSSQSPPTKFLELIGIA-QGQ-MTVLRLTELLERGERLPRPDKCPCEVYH JAK3_Hsap V-LYELFTYCDKSCSPSAEFLRMMGCE-RDV-PALCRLLELLEEGQRLPAPPACPAEVHE JAK2_Hsap V-LYELFTYIEKSKSPPAEFMRMIGNDKQGQ-MIVFHLIELLKNNGRLPRPDGCPDEIYM JAK1_Hsap T-LHELLTYCDSDSSPMALFLKMIGPT-HGQ-MTVTRLVNTLKEGKRLPCPPNCPDEVYQ hop_Dmel T-LFEMFSRGEEPNLVPI-------------QTSQEDFLNRLQSGERLNRPASCPDFIYD JAK3_Mmus V-LYELFTYCDKSCSPSAEFLSMMGPE-REG-PPLCRLLELLAEGRRLPPPPTCPTEVQE JAK2_Mmus V-LYELFTYIEKSKSPPVEFMRMIGNDKQGQ-MIVFHLIELLKSNGRLPRPEGCPDEIYV JAK1_Mmus T-LHELLTYCDSDFSPMALFLKMIGPT-HGQ-MTVTRLVNTLKEGKRLPCPPNCPDEVYQ TYK2_Mmus T-LYELLTYCDSNQSPHMKFTELIGHT-QGQ-MTVLRLTELLERGERLPRPDRCPCEIYH JAK1_Spur V-LWEMFSYGQDPIYQD----------SKGRRVEHIELLDFFEKGMRLTHPPSCPAAIET JAK2_Spur YIFFKIHTGFDKVA-YIM-----------------CAYI--------------------- : :: : :. TYK2_Hsap LMKNCWETEASFRPTFENLIPILKTVHE-KY----QGQ-----------APSVFSVC JAK3_Hsap LMKLCWAPSPQDRPSFSALGPQLDMLWS-GS----RGCETHAFTAHPEGKHHSLSFS JAK2_Hsap IMTECWNNNVNQRPSFRDLALRVDQIRD-NM------------------------AG JAK1_Hsap LMRKCWEFQPSNRTSFQNLIEGFEAL-----------------------------LK hop_Dmel LMQLCWHATPRSRPSFATIVDIITREVATKVTHPTDGHQ--------SPPNQPTDAE JAK3_Mmus LMQLCWAPSPHDRPAFGTLSPQLDALWR-GR------------------------PG JAK2_Mmus IMTECWNNNVSQRPSFRDLSLRVDQIRD-SI------------------------AA JAK1_Mmus LMRKCWEFQPSNRTTFQNLIEGFEAL-----------------------------LK TYK2_Mmus LMKNCWETEASFRPTFQNLVPILQTAQE-KY----QGQ-----------VPSVFSVC JAK1_Spur MMNDCWEMDPLKRPKFQSMIVRLGILVQ-NS---ERGE---------MGSSSSSYGL JAK2_Spur --------------------------------------------------YCCKVLK