CLUSTAL W (1.83) multiple sequence alignment LRRK2_Hsap MASGSCQGCEE-D----------------------------------------------- LRRK1_Hsap MAGMSQRPPSM-----Y--WCV--G----------------------------------- CG5483_Dmel MEHPKTGTETA-L---E--ACD-------------------YFVDE-------------- LRRK2_Mmus MASGACQGCEE-E---E--E---------------------------------------- LRRK1_Mmus MAGTSQRPPSM-----Y--WCV--G----------------------------------- T27C10.5_Cele MDLSSGGPSSS-S---D--VAS--------------------ELDN-------------- GbpC_Ddis MSQKQKPIRFQ-----D--YQF--T----------------------------------- Pats1_Ddis MEILNLSIEFHIPDGNT--L----K---------------------------KMV-RVDN QkgA_Ddis MDLEQDEWMSQ-----R--Q----R----------------------------------- QkgA_C2d_Ddis MDLEQDEWMSQ-----R--Q----R----------------------------------- Roco10_Ddis MSGLLDDDEII-----Q--VS--------------------------------------- Roco11_Ddis METSQIRNGF-------------------------------------------------- Roco4_Ddis MDSSQQLQESQ-----Q--L----Q----------------------------------- Roco5_Ddis MEVIKKEKKDK-----E--KK--------------------------------------- Roco6_Ddis MNSIHKQHYTI-----N--SNH--Y----------------------------------- Roco7_Ddis MDGYSSLSSSG-----N--SIA--PPRPTNNSVGGGSNSNNYNQREITTPLRGMVPNLGD Roco8_Ddis MFDYNQLNKLK-----D--KIQ--S----------------------------------- Roco9_Ddis MTSIANLFDKK-----S--KRS--N----------------------------------- LRRKd_Spur VPQPY------------------------------------------------------- LRRKc_Spur MDNYDMLQDAC-----T--ALL-------------------------------------- LRRKb_Spur MESPVTPDEER-I---R--RKL--L----------------------------------- LRRKa_Spur MVNMVVL----------------------------------------------------- AqueK485_Aque MDGTEVIVAVF-G-------CP-------------------GVGKS-------------- AqueK486_Aque MMTAKAPDYQP-V---E--RYG--H----------------------------------- AqueK487_Aque MATWCSLQPV-------------------------------------------------- AqueK488_Aque MQNMGVVKEHV-F---D--CKM--E----------------------------------- AqueK489_Aque MAKAAESENTS------------------------------------------------- AqueK490_Aque MAALLPPETQG-I---D--KAI--F----------------------------------- AqueK491_Aque MSGKENVYAPS-----D--VT--------------------------------------- AqueK492_Aque MAGVMQDDAKL-L---H--KFC--H----------------------------------- AqueK493_Aque MGQ--------------------------------------------------------- AqueK494_Aque MSAGAGRRRHS-M---E--ASA--F----------------------------------- AqueK495_Aque MLTPIIPYFLI-YG--GFSCLVVSI----------------------------------- AqueK496_Aque MAEVRKLAETL-----G--TIL--S----------------------------------- AqueK497_Aque MLSSVKFLGAG-I---D--K---------------------------------------- AqueK498_Aque MARGSSFLRFF-----E--PSV--D----------------------------------- : LRRK2_Hsap ---EET-----------LK-KL-------------IVRLNNVQEGKQIETLVQI------ LRRK1_Hsap ---PEE-----------SAVC--------------------------PERAMET------ CG5483_Dmel ---VIE-----------AS-S--------------------------IRDA--------- LRRK2_Mmus ---EEA-----------LK-KL-------------IVRLNNVQEGKQIETLLQL------ LRRK1_Mmus ---TEG-----------LAVC--------------------------PGPAMET------ T27C10.5_Cele ---SDA-----------MQ-L--------------------------VRQA-------VL GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ---TTK-----------I---------------------------------GEM------ QkgA_Ddis ---QQQ-----------M----------------------------------EF------ QkgA_C2d_Ddis ---QQQ-----------M----------------------------------EF------ Roco10_Ddis ---PDS-----------I----------------------------------IT------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis -----------------Q----------------------------------QY------ Roco5_Ddis ----DK-----------E----------------------------------EK------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis GSSSQT-----------L----------------------------------LF-KNILL Roco8_Ddis ---SDG-----------L----------------------------------QIKDRTYL Roco9_Ddis ---EDT-----------G-----------------------------------EKEETKK LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ----------------------------------------------------EI------ LRRKb_Spur ---DT-LLLL-------------------------------------------------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ---TFI-----------SN-A--------------------------LEGQ--------- AqueK486_Aque ----ST-----------V--RVGDYLYMWGGDQPDLPRVHNNEKKKSM---CSV------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ---NE---------------D--------------------------IRTLV-T------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ---A------------------------------------------------E------- AqueK491_Aque ---EDL-----------T----------------------------------A------- AqueK492_Aque ---DGK-----------IE-KIKDFV--ATVE---------------------------- AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ---SR-PALFRPHFSSTS--N--------------------------LNASV-A------ AqueK495_Aque ---HYPI--------SSKD-V--------------------------LKSLKS------- AqueK496_Aque ---AEP-----------SD-N--------------------------QKKLFE------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ---PSL-----------VD-D--------------------------TDRLIDF------ LRRK2_Hsap ------LEDLLVFTYSERASKLFQGKNIHVPLLIVLDSYMRVASVQQVGW---------- LRRK1_Hsap ------L--------------------------NG--------------A---------- CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------LEDMLVFTYSDRASKLFEDKNFHVPLLIVLDSYMRVASVQQAGW---------- LRRK1_Mmus ------H--------------------------NG--------------A---------- T27C10.5_Cele FEN--------------------------------------------------------- GbpC_Ddis ----------------------------------------A------TKD---------- Pats1_Ddis ------S---------------------------------R------LLL---------- QkgA_Ddis ------S---------------------------------R------IGI---------- QkgA_C2d_Ddis ------S---------------------------------R------IGI---------- Roco10_Ddis ------S--------------------------SIGSA--S------LNY--SVNGADDN Roco11_Ddis ------N---------------------------------K------VEV---------- Roco4_Ddis ------T---------------------------------R------VGI---------- Roco5_Ddis ------K--------------------------DKEKK----------DKSEKKEKKDKE Roco6_Ddis -------------------------------------------------N---------- Roco7_Ddis LQDVEFF---------------------------------C------SIL---------- Roco8_Ddis YKTYRSV---------------------------------F------VGY---------- Roco9_Ddis ---SRS------------------------------------------GT---------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------L--------------------------EK------------------------- LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------ME-VCHLRTGRWEQKPTT---GDPPL---------------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------F--------------------------NRGK----------------------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque --L---Y---------------------------------R------------------- AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------S--------------------------SRGMQPLK------EQD---------- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------L--------------------------SA------------------------- LRRK2_Hsap ---------------------------SLLCKLIEVCPGTMQSLMGPQ------------ LRRK1_Hsap ---------------------------G-------------------------------- CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ---------------------------SLLCKLIEVCPGTLQSLIGPQ------------ LRRK1_Mmus ---------------------------E-------------------------------- T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ---------------------------E-------------------------------- Pats1_Ddis ---------------------------D-------------------------------- QkgA_Ddis ---------------------------E-------------------------------- QkgA_C2d_Ddis ---------------------------E-------------------------------- Roco10_Ddis KSI---PPS------SPQQNLLE---ND-------------------------------- Roco11_Ddis ---------------------------D-------------------------------- Roco4_Ddis ---------------------------D-------------------------------- Roco5_Ddis KKEKEKKEKKEKEKEKEKDKEKDGGLFS-------------------------------- Roco6_Ddis ---------------------------E-------------------------------- Roco7_Ddis ---------------------------D-------------------------------- Roco8_Ddis ---------------------------ECVDW---------------------------- Roco9_Ddis ---------------------------LKFKT---------------------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ----------------------------------------GVRSYAAAAIGREIFYFGGY AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ---------------------------D-------------------------------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ---------------------------E-------------------------------- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap --------------DVGNDWEV-------------------------------------- LRRK1_Hsap --------------DTGGKPSTRGGDPAARSRR--------------------------- CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus --------------DIGNDWEV-------------------------------------- LRRK1_Mmus --------------DMGSKLSLPGGSSTVQCPS--------------------------- T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis --------------A--------------------------------------------- Pats1_Ddis --------------K--------------------------------------------- QkgA_Ddis --------------V--------------------------------------------- QkgA_C2d_Ddis --------------V--------------------------------------------- Roco10_Ddis --------------T--------------------------------------------- Roco11_Ddis --------------V--------------------------------------------- Roco4_Ddis --------------V--------------------------------------------- Roco5_Ddis --------------I--------------------------------------------- Roco6_Ddis --------------S--------------------------------------------- Roco7_Ddis --------------N--------------------------------------------- Roco8_Ddis --------------I--------------------------------------------- Roco9_Ddis --------------L--------------------------------------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur --------------------------------S--------------------------- LRRKb_Spur --------------------KLCS-------QYVKSSPNSTIVLMILMCSPFIMDFATLS LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque CNHEDCYYNSLYSFNV----DT-------------------------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque --------------VI-------------------------------------------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque --------------VLASPAEFI--------NAMKTSKAEE--MLVYACGKL-------A AqueK495_Aque -------------------------------SI--------------------------- AqueK496_Aque -------------------------------DH--------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur TEIPPGAVAS---TLQEYHAHAQVLQVMDQHTYNADIQEAGCNALAA------------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque QAL-DDD-NPELADVKEEEVIRVTYQMMINHPLNSNLLQLACEVFLRCNSKAAYRGIVEE AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap -------------------------------------------LGVHQLILKMLTVHNAS LRRK1_Hsap -----------------------------TEGIRAAYR--RGDR---------------- CG5483_Dmel -----------------------------REE---------------------------- LRRK2_Mmus -------------------------------------------LGIHRLILKMLTVHHAN LRRK1_Mmus -----------------------------MEEIHTAYK--QRNL---------------- T27C10.5_Cele -----------------------------VEL---------------------------- GbpC_Ddis -------------------------------------------Y---------------- Pats1_Ddis -------------------------------------------F---------------- QkgA_Ddis -------------------------------------------I---------------- QkgA_C2d_Ddis -------------------------------------------I---------------- Roco10_Ddis -------------------------------------------L---------------- Roco11_Ddis -------------------------------------------V---------------- Roco4_Ddis -------------------------------------------I---------------- Roco5_Ddis -------------------------------------------V---------------- Roco6_Ddis -------------------------------------------I---------------- Roco7_Ddis ---------------FC--------------------RS--SST---------------- Roco8_Ddis -------------------------------------------F---------------- Roco9_Ddis -------------------------------------------F---------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur -----------------------------SDSVKEAYKYMQALP---------------- LRRKb_Spur -------------------------MMQVSD----------------------------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque -----------------------------FER---------------------------- AqueK486_Aque -------------------------------------------FKWKKLSPIYTTSHHGP AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ---------------WC--------------------KE--GNT---------------- AqueK491_Aque ---------------AA--------------------MW--GDV---------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque YAVFRTQSDWSIATLYCKELSQSQAYLDIAG----------------------------- AqueK495_Aque --------------------------------LPLL--HP-------------------- AqueK496_Aque ----------------------------------ME--YGR-KT---------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque -----------------------------SERLPRLLS--R------------------- LRRK2_Hsap VNLSVIGLKT-----LDLLLTSGK------------------------------------ LRRK1_Hsap ------G----------------------------------------------------- CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus VNLSIVGLKA-----LDLLLDSGK------------------------------------ LRRK1_Mmus ------S----------------------------------------------------- T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------G----------------------------------------------------- Pats1_Ddis ------G----------------------------------------------------- QkgA_Ddis ------G----------------------------------------------------- QkgA_C2d_Ddis ------G----------------------------------------------------- Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------G----------------------------------------------------- Roco4_Ddis ------G----------------------------------------------------- Roco5_Ddis ------G----------------------------------------------------- Roco6_Ddis ------N----------------------------------------------------- Roco7_Ddis ------Q----------------------------------------------------- Roco8_Ddis ------G----------------------------------------------------- Roco9_Ddis ------G----------------------------------------------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------E----------------------------------------------------- LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque MMKAYCGMVAIKVNGEDYLVVIGGLGPMASSNNTPPQPGAQYSGGGFITYQRCNEIHFYK AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------G----------------------------------------------------- AqueK491_Aque ------A----------------------------------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------S----------------------------------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ---------------------RSD------------------------------------ Pats1_Ddis ---------------------RSDFD--------------------PSQF---------- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ---------------------------SPPPPLPTQTINTSSSPPPPTI----------- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis -----------------GWVGN-LTEPTPP------------PPPPPSSVSAQSTAEANA Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque LSTGQWISPTVTGDRPPP------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ----------------------------------------------------G------- CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ----------------------------------------------------R------- T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis -----------------------------------QLIV-------------PQKTATIS QkgA_Ddis ----------------------------------------------------S------- QkgA_C2d_Ddis ----------------------------------------------------S------- Roco10_Ddis --ITTTTTTTTTTAMSPVATTTTSSPTISASPTYITSPSGTRLSGGNTFNAQQ------- Roco11_Ddis ----------------------------------------------------P------- Roco4_Ddis ----------------------------------------------------P------- Roco5_Ddis ILLNPTTQENHKK----------------------------------------------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ----------------------------------------------------K------- Roco8_Ddis ----------------------------------------------------NC------ Roco9_Ddis ----------------------------------------------------TS------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ----------------------------------------------------D------- LRRKb_Spur ----------------------------------------------------K------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ----------------------------------------------------L------- AqueK490_Aque ----------------------------------------------------R------- AqueK491_Aque ----------------------------------------------------L------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ----------------------------------------------------V------- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ----------------------------------------------------A------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------ITLLILDEESDI------------------------------------------ LRRK1_Hsap ---ARD-----------LLE-----------------EAC------------DQCASQLE CG5483_Dmel ---VRQ-----------I-----------------------------------------K LRRK2_Mmus ------LTLLILDEECDI------------------------------------------ LRRK1_Mmus ---ARD-----------LLR-----------------GVC------------EESESSQE T27C10.5_Cele ---LAD-----------LFK---------VN--------------PWVW------NRVDR GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis FHVLSD-----------LN----------------------------------------- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ---VRD-----------KLFPFY-----SHHSLGIERAMCGNQTLKEMPGRSDQE-ELYA LRRKb_Spur ---LKD-----------LVH-KKNIHSQV-------------------------LEIMDK LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ---KR------------------------------------------------------E AqueK486_Aque ---IYDFTLTSINNSSAI------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque -----D-----------LAQ-YW-----V-------------------------EENKDK AqueK489_Aque ---LEK-----------LL----------------------------------------- AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ---LES-----------LL----------------------------------------- AqueK492_Aque ----PEILFNLLNNRR-------------------------------------------- AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ---LRN------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ---LQK-----------II----------------------NHP------------IQRY AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ---------------------------------------------------------KDD LRRK2_Hsap ----------------------------------FMLIFDAMHSFPANDEVQKLGCKALH LRRK1_Hsap KG---------------------------------------------------------- CG5483_Dmel HG---------------------------------------------------------- LRRK2_Mmus ----------------------------------FLLIFDAMHRYSANDEVQKLGCKALH LRRK1_Mmus KG---------------------------------------------------------- T27C10.5_Cele HG---------------------------------------------------------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis -------------------KSLSSYNI--KNNDELIFKKRQKKTNPGN------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur RF---------------------------------------------------------- LRRKb_Spur HKDDPKVQASAMKTIAFLA-MAEDTCIAMLGEDVMEAILEAMKLFPGNAPVQK------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque AG---------------------------------------------------------- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque PGDV--------T----------------------------------------------- AqueK489_Aque -------------------IKVSSFHQQLPD---DLFKWGQ---TMLN------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque -------------------SNGA-----DP-------NLPN---SQGN------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque NLSDVYIVTGSTAALSYVLRDHMFAHINLLQLNFHSILFDVLKLHSSNPEIVC------- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque NG---------------------------------------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque RG---------------------------------------------------------- LRRK2_Hsap VLFERVSEEQLTEFVENK----DYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNV-- LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus VLFERVSEEQLTEFVENK----DYTILLSTFGSFRRDKEIVYHVLCCLHSLAVTCSNV-- LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque -LFGGSTTN--------RLSNNVYIL--------------------NFTDTSVNCSKLSN AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ---------------EVLMSGNVRCYNI---------------------------V---- LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ---------------EVLMSGNVRCYNL---------------------------V---- LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ----------AK---LVSKKKPESIFKTLF----------------------SMSTLEMK QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur -------NACNALKQL--LTDEDCY-DVLLQ----------------------------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque PGGTVQWPKGRHAHSSVLISTSLGPYLL---------------------------V---- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ----------STLLKSTQFGNR-------------------------------------- AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ----------TALHVACYYGERECA-SILLHYKAEVNAKGAEGKIPLHRAVLGVCVLE-- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque -------NVFLVFRLI--STEDRCK-QVLLE----------------------------- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis LGEDKSAPEIS----EVENQIDDLGILFK-ALEI-------------------------L QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis -------PDIK----TREDAIKLGQTLFD-A----------------------------- Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque -----PGPKYQSREQISENQIDLVKLLVGNGSKVTFHDGYGDTPYDAALQCDFYECAELL AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis TNSFNQNKDIEDIV---------------------------------------------- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------ET-HKDII---------------------------------------------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque -------------VGGAGTDDIWIFNINNKSWKEQEQVNLPDNATDRCYHSLSVWSVTPT AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ----------SDLA---------------------------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------SSLFQLSL---------------------------------------------- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------VEAMKA--FPMSERIQEVSCCLLHRLTLG---NFFNILVLNEVHEFVVKAVQQY LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------VEAMKA--FPTNENIQEVSCSLFQKLTLG---NFFNILVLNEVHVFVVKAVRQY LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------RY----------------------------V----------- Pats1_Ddis -------SSFQ--YVGNESE----------------------------I----------- QkgA_Ddis ------------------------------------------------K----------- QkgA_C2d_Ddis ------------------------------------------------K----------- Roco10_Ddis ------------------------------------------------L----------- Roco11_Ddis ------------------------------------------------L----------- Roco4_Ddis ------------------------------------------------M----------- Roco5_Ddis ------------------------------------------------A----------- Roco6_Ddis ------------------------------------------------I----------- Roco7_Ddis ------------------------------------------------I----------- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur -------AAIKR--FPDNVGLQTACCALIEALAQTE--DSQQLFVLNDV----------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque TNWIIVF-----------------------------------------------GGSTLY AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------L----------- AqueK491_Aque -------NAYDACKVGDLTK----------------------------V----------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque -------EYLQS--YQEDVPVVTSLCSVIESLASTESTDFMELAASVPL----------- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap PENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEDKLF-------------- LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus PENAALQISALSCLALLTETIFLNQDLEERSETQEQSEEEDSEKLF-------------- LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ---------------------------------------------KQFLNKN-------- Pats1_Ddis ---------------------------------------------ADLVKIV-------- QkgA_Ddis ---------------------------------------------KDLIVNS-------- QkgA_C2d_Ddis ---------------------------------------------KDLIVNS-------- Roco10_Ddis ---------------------------------------------KSLLLA--------- Roco11_Ddis ---------------------------------------------KDLLVRV-------- Roco4_Ddis ---------------------------------------------KDLIISV-------- Roco5_Ddis ---------------------------------------------MDFWVTN-------- Roco6_Ddis ---------------------------------------------NSLLLND-------- Roco7_Ddis ---------------------------------------------TDLINSL-------- Roco8_Ddis ----------------------------------------------GIICNV-------- Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ---------------------------------------------SDLLIDALR-RFSDN LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque TDTAVIELRYTSNNDWFTSIIPLDQYQEKLQ-ERRNEDKIEIDHLT-------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ---------------------------------------------RDFLYHE-------- AqueK491_Aque ---------------------------------------------KELMPGI-------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ---------------------------------------------SSLVYSSLQLHYKES AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap -----------------------------------WLEACYKALTWHRKNKHVQEAACWA LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus -----------------------------------WLEPCYKALVRHRKDKHVQEAACWA LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ---------------------------------------SNIPIPPVPTSPTSTPPNLQT Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ---------------------TSTTTTTTTTTSSN-NIPSLVSV---------------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ARYLTICLSVMDRLAEAIFTAPKW--LDRMLNDNW-MNETFMALTKHQDSPPCLENALRA LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ----------------------------------HLLQERERELEEERREK--------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ---------------------PNAQAYF-------------------------------- AqueK491_Aque ------------------------VVMI-------------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque VQLCAYGFSLFSYLSSRLPLITNHLRLEDLL--RF-MS---SVFEVHGSDTEFQEAFCRC AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap LN-----------------------------NLLMYQN-SLHEKIGDEDG---------- LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus LN-----------------------------NLLMYQN-SLHEKIGDEDG---------- LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis NN-----------------------------NNKQ------------------------- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur LT-----------------------------TLVSNRPGMLVEMLTEESE---------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque -EQVRNRLQQQFQGRERQLQQAQQQGQERERQAREQVQ-DLHRQLREKER---------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque -------------------------------NTKM------------------------- AqueK491_Aque -------------------------------NECK------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque LG-----------------------------GLFEASP-QLHMFVGEGGGGGGEGGGGGG AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------HFPA-----------HREVMLSMLMHS-SS------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------QFPA-----------HREVMLSMLMHS-SS------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------SMAV-----------DSAVLMSLRLHSKNS------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------EFQE-----------REQQLLRQVEGG-QQREQDLQRQLQLREQQLEEREREFQ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque GGNEESSLSTAGEIRVPIINWIWVVLLSNLSDT-QQ------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap -----------------------------------------------KEVFQASANALST LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus -----------------------------------------------KDVFQAAAHALST LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur -----------------------------------------------KIIFEMGCDAIQA LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ERERQFEEQIQVAESSWVVNRREITMTEVVLGKGGWGEVKVAGFRGLKVAAKCLYEVIIS AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque -----------------------------------------------YKVFESVCLAVYY AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap LLEQNVNFRKILLSKGIHLN---------------------------------------- LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus LLEQNVNFRKILLAKGVYLN---------------------------------------- LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur LAENSDMMQRTLAEKGALMDIRSGMVT--YARSP---ECQAAASRAIRGLCLAIEYRDDS LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque PYNIEIFSRE-------------------------------------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque LGVDSDRLRKLLLDKGGASAIFEGLRRFKGIQEPRFERCLQYGCRALLALIMS---PGS- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ----------------VLELMQKHIH---------------------------------- LRRK1_Hsap ---------------QL------------------------------------------- CG5483_Dmel --------------E--------------------------------------------- LRRK2_Mmus ----------------VLELMQKHAH---------------------------------- LRRK1_Mmus ---------------QL------------------------------------------- T27C10.5_Cele --------------RTP------------------------------------------- GbpC_Ddis ---------------LL------------------------------------------- Pats1_Ddis ---------------LS------------------------------------------- QkgA_Ddis ---------------MK------------------------------------------- QkgA_C2d_Ddis ---------------MK------------------------------------------- Roco10_Ddis -----------DK--DK------------------------------------------- Roco11_Ddis ---------------MK------------------------------------------- Roco4_Ddis ---------------MN------------------------------------------- Roco5_Ddis ----------------Q------------------------------------------- Roco6_Ddis ---------------LN------------------------------------------- Roco7_Ddis ---------------IV------------------------------------------- Roco8_Ddis ---------------TS------------------------------------------- Roco9_Ddis ---------------KK------------------------------------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ---------------GF------------------------------------------- LRRKb_Spur IHLDNKQAVTEAGIHTL------------------------------------------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque --------------N--------------------------------------------- AqueK486_Aque -----------------MNIASKLRHPNLLQFIGATTEVMAGVFRGVFQDDANLHKFCHD AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque --------------TFL------------------------------------------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque -----------TKGNTL------------------------------------------- AqueK491_Aque -----------KEYMTL------------------------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque --------------RTL------------------------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque --------------YTL------------------------------------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ---------------------------------LSI------------------------ CG5483_Dmel ---------------------------------LRT------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ---------------------------------LSI------------------------ T27C10.5_Cele ---------------------------------LML------------------------ GbpC_Ddis ---------------------------------KKK------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ---------------------------------DEK------------------------ Roco7_Ddis ---------------------------------ILD------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ---------------------------------LHA------------------------ LRRKb_Spur ---------------------------------LFEAVRNFIGDVEVLLDIVNTITCLAD LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque GKIEKIMDFVATVEPEILLDRLNNRRGISGYTPLHE------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ---------------------------------LFP------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ---------------------------------IHE------------------------ AqueK491_Aque ---------------------------------LMI------------------------ AqueK492_Aque --------------------------GVFGYTPLHE------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque -----------------------------------SGMKDFLVQVEA------------- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ---------------------------------VHI------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ---------------------------------LHY------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur MDVVKYQCMVEGIHEVILQGMAEYQDDPNIQELFLETMVVLSSAEGMIDILVEAGILSLT LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur VELMEKYSQIEAIQENGTILLQTVVNKKKSICDDRLAEKIARAIISSMKKFRKAPSILAE LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ----------------------------------------IYDLIDILDNHTAAPDIAAE AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur SCVAMQFLADISQEVTKTLVNYNAHEELFHILEAYKDDDTLVNLVCECLYILCCKWEFTD LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ALGV-----------------------MACLSDNGRFRAAAIQQN--------------- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ----------SPEVAESGCKMLNHLFE-GSNTSLDIM----AA--------VVPK----- LRRK1_Hsap -----PAAYGD-------LEMVRYLLSKRLVELPTEPT----D--------DNPA----- CG5483_Dmel -----AVISGD-------ERTVRVLLAALGT------------------------ERQ-I LRRK2_Mmus ----------APEVAESGCKMLSHLFE-GSNPSLDTM----AA--------VVPK----- LRRK1_Mmus -----AAAHGD-------LETVQFLLTEKRVELPTEPT----D--------DNPA----- T27C10.5_Cele -----AAHNGK-------LDSLRTILMLSPN----------------------------- GbpC_Ddis -----DGTLGT-------AEELLTLIQQSNINVVTAST---------------------- Pats1_Ddis -------------------------------------------------------NNDGL QkgA_Ddis -------------------------------------------------------NH--- QkgA_C2d_Ddis -------------------------------------------------------NH--- Roco10_Ddis -------------------------------------------------------DN--- Roco11_Ddis -------------------------------------------------------NI--- Roco4_Ddis -------------------------------------------------------SL--- Roco5_Ddis -------------------------------------------------------NN--- Roco6_Ddis ---------------------------------RTTST---------------------- Roco7_Ddis -----DSF----------LELLRLFIKQTIDQAKQCST---DE--------SNPLNY--- Roco8_Ddis -------------------------------------------------------GA--- Roco9_Ddis -------------------------------------------------------DK--- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur -----SCKKGD-------VDAAHMLMCWGIEPCCKNTE----G--------RSAL----- LRRKb_Spur QMLLWACKENL-------MKGVEVLVELGADVN-----TGEGY--------ETPM----- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------QRYITGSVKMCGR------------------------EV--- AqueK486_Aque -----AVSGNR-------YEVISYLVELGANVNARAN----FG--------YTPL----- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque -----AAKAGQ-------PDTLEKFIRYGDLSQIEKDDKSHLG--------WNIY----- AqueK489_Aque -------------------HVVSLLIKFGANNYKECID---S------------------ AqueK490_Aque -----AVENGQ-------PDVLQLLLQNGI-SSETKGK---NN--------QTPL----- AqueK491_Aque -----ASREGH-------SAIVDYLIDIGAKVTHTLGS---TA--------KTAL----- AqueK492_Aque -----AVSGNR-------LKVIPYLIEQGANVNAKAN----SG--------YTPL----- AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque -----------------------------------------VHARVLNLIQYKPT----- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque -----AADKGL-------SEYLEKLLLEGGDPNKPSSV-PDLC--------QTPL----- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque -----AAERDR-------PESLKILLINGADPNIRTSH-NSFE--------ITPL----- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis SSNSNNNSSSNIGSMLNSGGGGSGSNLGLGLSSGTGGSFNGNSSGSSSSSSYYYNNNNNN QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel --------------IVNMA------------PS--------------------------- LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele --------------SLNLV------------ND--------------------------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis NNIELTAQQKNPKVLCSFI------------LH--LLQ---------------------- QkgA_Ddis ------------ETTLTII------------NE--TYR---------------------- QkgA_C2d_Ddis ------------ETTLTII------------NE--TYR---------------------- Roco10_Ddis ------------ETFATLI------------NE--ELP---------------------- Roco11_Ddis ------------NTPFKIL------------NE--TFK---------------------- Roco4_Ddis ------------DTTFKII------------NE--TYR---------------------- Roco5_Ddis ------------NTSNNNI------------NN--NNK---------------------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------QSFYNLI------------NR--MAA---------------------- Roco8_Ddis ------------D---PIF------------KD--DYI---------------------- Roco9_Ddis ------------EK--KILQQLQQQQDDEQQQQQQQFMEGDNNNNNTNSLNTPSVEGDSE LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque --------------PVKIV----------------------------------------- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------ILTVMKRHETSLPVQLEA------------------------ LRRK1_Hsap ------------------VVAAYFG-------HTAV------------------------ CG5483_Dmel ------------GANTLLFLACQSG-------YESI------------------------ LRRK2_Mmus ------------------ILTVMKAHGTSLSVQLEA------------------------ LRRK1_Mmus ------------------VVAAHFG-------HAEV------------------------ T27C10.5_Cele ------------RGKTALHMAAESG-------ETSI------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis -----------I------------------------------------------------ QkgA_Ddis -----------I------------------------------------------------ QkgA_C2d_Ddis -----------I------------------------------------------------ Roco10_Ddis -----------L------------------------------------------------ Roco11_Ddis -----------I------------------------------------------------ Roco4_Ddis -----------I------------------------------------------------ Roco5_Ddis -----------TSNTTGSNVSSSNN-------KETVKINVTSLDSGGNNNASGKDISNEH Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis -----------I------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis NINRLAASTNST------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------EIATTEG-------HLNI------------------------ LRRKb_Spur ------------------CFACEN------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque -------------------EEPELT-------TRAI------------------------ AqueK486_Aque ------------------HLAASAG-------HIEC------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------HYAVY------------------------------------- AqueK489_Aque --------------------SRQNN-------HI-------------------------- AqueK490_Aque ------------------HIAAAKG-------HVDC------------------------ AqueK491_Aque ------------------HYAAENG-------HADV------------------------ AqueK492_Aque ------------------HLAAIVG-------HIEC------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------HSVLVE------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------HLAAFQG-------YAKC------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------HIAAANG-------HLDC------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ---IFSQTSLTYSLYITY------------------------------------------ QkgA_Ddis ---V-------------Y------------------------------------------ QkgA_C2d_Ddis ---V-------------Y------------------------------------------ Roco10_Ddis ---T-------------TEE--KENIKAQKKD---------------------------L Roco11_Ddis ---N-------------Y------------------------------------------ Roco4_Ddis ---V-------------Y------------------------------------------ Roco5_Ddis SPKN-------------RKEKEKEKDKDNKEDSINESPVDENRRKLVEGFMKSLQGCSDA Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ---Y-------------L------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ---S-------------Y------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap VQE--------------------------------------------------------- CG5483_Dmel TQRLLDAGADGRSHAVTKYSP--------------------------------------- LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus VRE--------------------------------------------------------- T27C10.5_Cele VLELVELGSDPMKSDNEGHCA--------------------------------------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ISS--------------------------------------------------------- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis IKV--------------------------------------------------------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ITE--------------------------------------------------------- LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque L----------------------------------------------------------- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque -TA--------------------------------------------------------- AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque IKT--------------------------------------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ----------------------------------TLLMEDIGP------LPDGVIKDNS- AqueK496_Aque LQVLVKHGAQIRVQNAHRTTPIDLVRGK--TVCESILQEAIGKVEVPNRTQDQLQR--V- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque LKRLVESGGDPLLRDSKNRLPRDHAQGNRQELCLEYLQKESA-----TVIKSGI-SEPLT LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque --LAVIVLFC----------------NKKE------------------------------ AqueK496_Aque --MDLHRLID----------------QQRE------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque TIFYLVIMADVSEYLEAGDFESLFNYDNFNKSFPLDSSKPTPTTPEDNIIERQEIHTFIL LRRK2_Hsap -------------------------------------------------------LRAIL LRRK1_Hsap ----------------------------------------------------------LL CG5483_Dmel -------------------------------------------LYAAVHSGHLGIARLML LRRK2_Mmus -------------------------------------------------------LRAIL LRRK1_Mmus ----------------------------------------------------------LL T27C10.5_Cele -------------------------------------------LELAQMAGHNEVAAKLI GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ----------------------------------------------------------LP Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ----------------------------------------------------------I- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ----------------------------------------------------------LV LRRKb_Spur --------------------------------------------------NNVDMVKQLL LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque -------------------------------------------------------VKALL AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque --------------------------------------------------GYQINCSYLL AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ----------------------------------------------------------LI AqueK492_Aque -------------------------------------------------------VRVLL AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque --------------------------------------------------SAI---ELLI AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ----DMDTFM---SLYSRLSALETDLSTRWTDW-----FQQTLLYRAADKDHVQIVTFLL AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque NTYTKHCNLLNNSTLVHSL--------SRFTRDFPISLHYVTILHAAVQYNHISLVSFLV LRRK2_Hsap ----H---------FIVP------------------------------------------ LRRK1_Hsap ----E---------SL-P------------------------------------------ CG5483_Dmel ----D------------------------------------------------------- LRRK2_Mmus ----H---------FVVP------------------------------------------ LRRK1_Mmus ----E---------SL-P------------------------------------------ T27C10.5_Cele ----D---------AI-Q-KES-------------------------------------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis EVPL-------------------------------------------------------- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ---LD---------VF-Y------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ----K---------ID-E------------------------------------------ LRRKb_Spur ----K---------QG-ISDLHTPLSRCLKLKQHHIIGLLLYQMGCDRQAGSLTWSSLGL LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ----Y------------------------------------------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ----N---------EK-SQAST-------------------------------------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ----K---------RL-P------------------------------------------ AqueK492_Aque ----D------------------------------------------------------- AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ----IFAQLDEKVHTV-FNE---------------------------------------- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ----Q---------QS-PAQPL-------------------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ----S---------NY-P------------------------------------------ LRRK2_Hsap --------------------------------------------GM-------------- LRRK1_Hsap --------------------------------------------G--------------- CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus --------------------------------------------GL-------------- LRRK1_Mmus --------------------------------------------G--------------- T27C10.5_Cele --------------EDLNEAHTMIISACISGSADVVYE-ISR---RFMEKSGKQSREILF GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis --------------------------------------------QP-LKKADLLSQ---- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur --------------------------------------------G--------------- LRRKb_Spur ARLNPEWLYKVFLDEEPPDPDSPND-----VVKYQCMVEGIHEVI--------------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque -------------------------------------------------------SIILF AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque --------------ANLT-PDEARQ-----I----------------------------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque --------------------------------------------R--------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque --------------------------------------SGIFREL--------------- AqueK495_Aque --------------HKEE-EQKTINTNDATDEIELFFKAFSDKPK--------------- AqueK496_Aque --------------SNLGHGDTPLMIACRHSNLKLVDLLINHSPG--------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque --------------------------------------------S--------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele NGRNEEDETA-------------------------------------------------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis --------EELKAIFSLIESISSFQQTILIDFKKYISNWNSTTQAQLHSTFLQFVGYLKL Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis --------------------------KSQLGGLMEKT---------MISQVLNFTPMIQE Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis -----------------------------------------------------SSLRSSS LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque DITSHETYME-------------------------------------------------- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap --PEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQKCGLKVISSIVHFP LRRK1_Hsap -PC--------------------------------------------------------- CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus --LEESREDSQC--RPNVLRKQCFRTDIHKLVLVALNRFIGNPGIQKCGLKVISSLAHLP LRRK1_Mmus -PC--------------------------------------------------------- T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis YKV--------------------------------------------------------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis QIV--------------------------------------------------------- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis TRS--------------------------------------------------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur -LL--------------------------------------------------------- LRRKb_Spur -LQ--------------------------------------------------------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque -----------------------------CSADISLIDSRGKTPKQTADLKKKSNVVRLL AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque -IL--------------------------------------------------------- AqueK492_Aque -----------------------------CSADVSLTDDYGKTPRQTASLGKNSNIVRLL AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque -IA--------------------------------------------------------- AqueK495_Aque -LF--------------------------------------------------------- AqueK496_Aque -LI--------------------------------------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque -LL--------------------------------------------------------- LRRK2_Hsap DALEMLSLE-GAMDSVLHTLQMYPDDQEIQCLGLSLIGYLITKKNVFIGTGHLLAKILVS LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus DATETLSLQ-GAVDSVLHTLQMYPDDQEIQCLGLHLMGCLMTKKNFCIGTGHLLAKILAS LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque RSEEIIKEAKTKGDNLTELLEVRIDDLE-------------------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque RSKEIIKEVKTNGDNLTELLRVRIDDLE-------------------------------- AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap SLYRFK------------------------------------------------------ LRRK1_Hsap -----S------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus TLQRFK------------------------------------------------------ LRRK1_Mmus -----T------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------L----------------------------------------------------- QkgA_Ddis ------Y----------------------------------------------------- QkgA_C2d_Ddis ------Y----------------------------------------------------- Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------C----------------------------------------------------- Roco4_Ddis ------F----------------------------------------------------- Roco5_Ddis -----YG----------------------------------------------------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis -----IL----------------------------------------------------- Roco8_Ddis ------F----------------------------------------------------- Roco9_Ddis -----ID----------------------------------------------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur -----E------------------------------------------------------ LRRKb_Spur -----GMAEYQDDPNIQELFLETMVV---LSSAEGMIDILVEAGILSLTVELMEKYSQIE LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque -----LY----------------------------------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque -----ILDRNMGESITYKCL-----MLIHILADED----------------HLSTYPRDC AqueK495_Aque -----VIGDNKPDTCQ----------------WPEAAQFVML------------------ AqueK496_Aque -----FI----------------------------------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque -----T------------------------------------------------------ LRRK2_Hsap ---------------------------------------------DVAEIQTKGFQTILA LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ---------------------------------------------DVAEVQTTGLQTTLS LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur AIQENGTILLQTVVNKKKSICDDRLAE----KIARAIISSMKKFRKAPSILAESCVAMQF LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque --------------------------RKIAWSLCSLLAPTQQSPTLTIEARIATAITLTF AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ILKLS-------------ASFSKLLVHHSFDLVIFHQMSSN------------------- LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ILELS-------------VSFSKLLVHYSFDVVIFHQMSSS------------------- LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ----------------------------------------------------LLIEISHF GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ----------------------------------------------KTN----------- QkgA_Ddis ----------------------------------------------DQY----------- QkgA_C2d_Ddis ----------------------------------------------DQY----------- Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ----------------------------------------------DQQ----------- Roco4_Ddis ----------------------------------------------DTD----------- Roco5_Ddis ----------------------------------------------LQY----------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ----------------------------------------------ANK----------- Roco8_Ddis ----------------------------------------------YQF----------- Roco9_Ddis ----------------------------------------------YNP----------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur LADIS-------------QEVTKTLVNYNAHEELFHILEAY------------------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ----------------------------------------------------L-SQLLEM AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------QLDIIYLLHQ-HKAPVT---AGLDIEQEDI AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ----------------------------------------------EE------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque LIHIDALVCACSLCKSCPNLMPQILVEFAVDTNIFRLLYSKPLEDLQFDNTD-------- AqueK495_Aque --------------------------------------------DDITQP---------- AqueK496_Aque ----------------------------------------------SEDQ---------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele SFEICFHKNLFQCLHKRSYRNRPSLITIRRASSTKPRIQGYSNPCGSVVTECGSVAAVFG GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------KDDDT-LVNL--------VCEC-------------------------------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque SHRVCPSAHVVVI-GAKADLRKP------HHVTTE---EAESFC---------------- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque LHPLPLHPSLMALGFECSFSEAAILIDMLSLSSSTAGSNGVG-----------------S AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ----TDNPEQL-IYEL--------AIDV-------------------------------- AqueK495_Aque ---EELNKLF----------KTIILEPLLFS----------------------------- AqueK496_Aque ---NSLSPLHVS----TSRGDKGIVQSMLDA----------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel -------------------------------------------HFPEL----------IQ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele VS-PSPVSNGGPFRDGEELENRRNRAFDISLWCLKILKLQIFQKFPQL----------VK GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur --------------------------------------------LYI----------LCC LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque HSAS----------------------------------------TPG--LDNIKVTSNND AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque --------------------------------------------VHS----------LSL AqueK495_Aque --M--------------------------------------------------------- AqueK496_Aque --VQ------------------------------------------GLYEKGITHRDLNL AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap PQRL-------------------------------------------------------- CG5483_Dmel QPTV-------------------------------------------------------- LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus PQRL-------------------------------------------------------- T27C10.5_Cele STNN-------------------------------------------------------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ---N---------NNNNNNNNNSSSPSNTDL-------------SRSTYFYDIP-VKSRI QkgA_Ddis ---E-------------------------------------------------------- QkgA_C2d_Ddis ---E-------------------------------------------------------- Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ---E-------------------------------------------------------- Roco4_Ddis ---E-------------------------------------------------------- Roco5_Ddis ---N-------------------------------------------------------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ---EAN----KNN----------------------------------------------- Roco8_Ddis ---DNN----KNNNNINNNNNNATSTATT------------------------------- Roco9_Ddis ---SNNGGNGGIRSDSFYSQTSESSDITSTSTTSPTMSAASSSSSSGTVKTPKPPKSSKL LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur DVAE-------------------------------------------------------- LRRKb_Spur KWEF-------------------------------------------------------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque HRRA-------------------------------------------------------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ---S-------------------------------------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque KEDC-------------------------------------------------------- AqueK495_Aque TQTD-------------------------------------------------------- AqueK496_Aque TDKI-------------------------------------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque QPSS-------------------------------------------------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ILKHIMLFLYNLTQRDASLLDSLSNIIGPFILGNVLLDPPPPPPSNSSPPISKSTS-NNN QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------ATAPITPVSTKIGSIGKSSS---- Roco9_Ddis --KHIYNSLKFKSLKTEKNGSSSSIKSNISNFEFIMPNTPLPIFDQQSPPIHF-YNSNQ- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis LNV--------------------------------------------------------- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis FSDFQYFGTPLYSLIKRQDNGLSIPILLEKSISFLEGHCHVEDLFFRKYNNEKVKFMRNS LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis FERTGDFNFYYPDPQDPYDVAALLVEFIASLPDQLLNVELYNAIKNHTSALNSQYGGYWD LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ----------------------------------------LN-WM--------------- CG5483_Dmel ----------------------------------------ERWLP--------------- LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ----------------------------------------LN-WM--------------- T27C10.5_Cele ----------------------------------------EGSTC--------------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ---------------------------------------SN-YHNNNNNNNNSNSNLSNS QkgA_Ddis ---------------------------------------SK-FTS--------------- QkgA_C2d_Ddis ---------------------------------------SK-FTS--------------- Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ---------------------------------------TK-TKSS-------------- Roco4_Ddis ---------------------------------------TK-LTSSNLDS--DDEEFESD Roco5_Ddis ---------------------------------------YS-LSS--------------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis IQYLAQKLSVESREFLQRLLFFLKKHVSACLFKQQQQQQQQ-RES--------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ----------------------------------------LK-LL--------------- LRRKb_Spur ----------------------------------------TD-QM--------------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ----------------------------------------LY-HL--------------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ---------------------------------------PK-GSS--------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ----------------------------------------RQ-KM--------------- AqueK495_Aque ----------------------------------------ID-KV--------------- AqueK496_Aque ----------------------------------------GR-TP--------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ----------------------------------------EGYTA--------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap --------------LALACQRGHLGVVKLL------------------------------ CG5483_Dmel --------------LHAACINGHIKLLELLISYSYPDYLYQTYRDEEG------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus --------------LALACQRGHLEVVKLL------------------------------ T27C10.5_Cele --------------LHWAARCGSSECVSTILNFPFPSE-FIIEIDTVG------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis GNGDESPDFQSQNLVKSYN----------------------------------------- QkgA_Ddis --------------CNIIT----------------------------------------- QkgA_C2d_Ddis --------------CNIIT----------------------------------------- Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis --------------FYIQT----------------------------------------- Roco4_Ddis DDADEEADLQIQASCNLYT----------------------------------------- Roco5_Ddis --------------LCLLM----------------------------------------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis --------------NNVLS----------------------------------------- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis --------------TEVL------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur --------------VCRACKAGKKEIIDYWF----------------------------- LRRKb_Spur --------------LLWACKENLMKGVEVL------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque --------------FEWAYNRGHLDVLTFC------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque --------------LHLAA----------------------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque --------------LISAVKHSMIEAIKLL------------------------------ AqueK495_Aque --------------SSLACVKGESNTLKLFLGLH---------------------QTPPT AqueK496_Aque --------------FYNACYHGQLPIVKAFLEFK---------------------AKFPD AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque --------------LHVAVSHKCFEIVQILTEAY-MNI-YRQRS---SSVALAMGGANPR LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel --QWEWR----------------------------------------------------- LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele --APAYQ----------------------------------------------------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------RE-----NSGNSLNSMLHQTSLPNNNNS-------------------- QkgA_Ddis ------------FDGKDKRS-------------------IK------------------- QkgA_C2d_Ddis ------------FDGKDKRS-------------------IK------------------- Roco10_Ddis ------------FISPSPTL-------------------SRNNNGKRNSGGNKPPLSPIK Roco11_Ddis ------------LDANDKSS-------------------LE------------------- Roco4_Ddis ------------FDGKNRQS-------------------VD------------------- Roco5_Ddis ------------FDNQRFES-------------------FINNAESKLVNEHKYSLAPLV Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------ANSTPNV---------------------T------------------- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ----------------------------------------T------------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------RNG-HADT-------------------VK------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque N-------TWL------------------------------------------------- AqueK496_Aque K-------IDINA----------------------------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque IRAPPSEAPLLFS----------------------------------------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ---------------------------------------------------------GG- Pats1_Ddis ------------------------------------------NVV-----NNNNNNNNNN QkgA_Ddis ------------------------------KM---------KRVV-----QKLSNESTN- QkgA_C2d_Ddis ------------------------------KM---------KRVV-----QKLSNESTN- Roco10_Ddis --ISSTSAAGDVSPSISLNNSGSGIYNSTSP--SGTASTQT-LNILSQLQQQQRNGNNNN Roco11_Ddis ------------------------------LT---------KSAI-----KNIQMQQQQQ Roco4_Ddis ------------------------------EI---------KRIV-----QHLNETQ--- Roco5_Ddis PTSSSSSCVKPVSLSEI---------------------------LGSQYDQTTSQSTNNS Roco6_Ddis ---------------------------------------------------------NNK Roco7_Ddis ----------A--------------------LKTSPA-IGSPRII-----M--GSNYNNS Roco8_Ddis ------------------------------KS---------STAV-----DKMNNNNNNN Roco9_Ddis ----------LSLSSSTSTLEPEPQPLPLSTS---------TQRLPQQSSDDNSNNDNNN LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------VL---------LDVA-----SGLFPP---- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis AAMG-------------------------------AMLNHTVS----------------- Pats1_Ddis NNNNNNN----------------------------NNNNNNNNNN--------------- QkgA_Ddis ---SSHQ----------------------------FD----------------------- QkgA_C2d_Ddis ---SSHQ----------------------------FD----------------------- Roco10_Ddis NNNNNNNYLSSPTMPALNKHSTHGNFHNSVAGYGNNNNNNNNNNKQPQHPMNGNHSPSNG Roco11_Ddis QQQQQQQ----------------------------QQ----------------------- Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis SG---------SSFPAVTLRRTGHTFTGIN--SANSNNNNNNSG---------------- Roco6_Ddis SNNN-------------------------------SNNNNNET----------------- Roco7_Ddis SNNNNI-----------------------------DSIDLNNNSP--------------- Roco8_Ddis NNNNNN-----------------------------NNNNNNNNSN--------------- Roco9_Ddis KNDNDN-----------------------------DNDNDNNN----------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ----------------------------TPERK--------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis --------------------NNNNNNINNNSTSSNNNNNNNSNNNN-SQI--------P- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis TSGSLSMSGSGIDNGGNNNNNSN--------------THGSSSNQ-SSGV---------- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis -----------GGSSGINNSNS---------------------------VTGKFTQEYT- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis --------------------NML--------------KNNSPSTFINGSV--------PQ Roco8_Ddis --------------------NSN--------------SNNNSSRRT-SSV--------P- Roco9_Ddis ----------------------D--------------N-NNINNDNGEII--------P- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque --------------------------------------------DSSSLD---------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel --------LPFDA-----NAHDVTGQ---------------------------------- LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele --------LALDV-----NEVDGECR---------------------------------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis -----PLI----------------QVRQPSSDFTTTS-----------------SGNLRS QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis INGGGGSY----------------NLTPI------------------------------- Roco8_Ddis -----PPV----------------LVTAS------------------------------- Roco9_Ddis -----PSI----------------QVTPPTSPQTQPKQQQPPQPPQKTLIEKLSE----- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque --------------------SGHRNG---------------------------------- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque -------------------------F---------------------------------- AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque -----EPVLPPDASVNVFSHSQAEGR---------------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque --------------------EEKSRR---------------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque --------------------PTNTGH---------------------------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel --------------TSLYIASILGN--KQLVGVLLKWQ----LHCRR------------- LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele --------------TAMYLAVAEGH--LEVVKAMTDFK----CT---------------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis LSNTENSLCKKVAID------------------LIQNIPLYLLFSHLKIQQLEGEKILFS QkgA_Ddis ------------------------------------------LHSHA------------- QkgA_C2d_Ddis ------------------------------------------LHSHA------------- Roco10_Ddis ---------------------------------------TSP------------------ Roco11_Ddis ------------------------------------------QQHHD------------- Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis -------------YS------------------NLASLLILPI----------------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque --------------TPYY------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque --------------LKICQAILDEE--EDVIDILLARN---------------------- AqueK490_Aque --------------------------------------------LRA------------- AqueK491_Aque --------------TPLHEAVIGGH--TDIVSMFVKWIRENQLKKPV------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque --------------SPLHAAVSAPKFSKEIVELLVK-EEELKLNIE-------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque --------------TPLHMSVALCE--REITLLFLSHAKQLSLSLE-------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------T------------LGDSASSVSTPITPTRKRISFGIQAIMSK LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis AENIFCVDKCNFPPNK-AMLGEIWVTNFRIIFINSN------------------------ QkgA_Ddis ------------------L------------LQ-SS------------------------ QkgA_C2d_Ddis ------------------L------------LQ-SS------------------------ Roco10_Ddis ----------------------I--------IQ--------------------------- Roco11_Ddis ------------------I------------FQ-FT------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ----------HFLARFHQFFKSL--------ID--------------------------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis -------------------------------LS-SS------------------------ Roco9_Ddis -----------------LFTPLF--------VN-YK------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------L------------LE-GG------------------------ AqueK491_Aque ------------------A------------L--GL------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque -----------------------------------A------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque -----------------------------------G------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel LHISGESEGPDDLASQESTECQRCPINVNLLCGAARETALLAAVRGG------------- LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ----------------SIDGRQRCPFQLDVYCTR-GRTPFMLAAFNQ------------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------EIANG------------- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque --------------------------------YPSSRSHKYIAKMLERKRSLTVFPSSSI AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque --------------------------------SACGYTALHLAVHFN------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis -------------------------------------------------TINL-T----- Pats1_Ddis ----------------------------------SNSSTIPN----STSSTSI------- QkgA_Ddis ----------------------------------SSSSSS-S----TSSSPSL------- QkgA_C2d_Ddis ----------------------------------SSSSSS-S----TSSSPSL------- Roco10_Ddis ----------------------------------STSPQPPH----LTGLN--------- Roco11_Ddis ----------------------------------QPSSSH-N----HS------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ----------------------------------SIAVLNPD----YKPYN--------- Roco6_Ddis -------------------------------------------------LEDI-I----- Roco7_Ddis ------------------------------------SSPT-I----GSSTPTIITS---- Roco8_Ddis ----------------------------------TSSSSSST----TSTSSSL------- Roco9_Ddis ----------------------------------THSAFYSS----TSTLITS--CEDIF LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ----------------------------------ADINST-DDFGNT------------- AqueK491_Aque ----------------------------------SPSSALS-----NSQVPVS------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque AQTYRAYTSFDQIESDDPPSYRDDRGCDTPISTSSAISDDLDAEIGITKRESL------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis VHIDERPITLPGEFIMMQIKNVIIPPTNLKLEHTISSSSKSDKNDKNDKNGNTDVTLWQS LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ----------------------------------------SSFASTQNLSILSIMTLFGS QkgA_Ddis ----------------------------------------T------------------- QkgA_C2d_Ddis ----------------------------------------T------------------- Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ----------------------------------------S------------------- Roco8_Ddis ----------------------------------------A------------------- Roco9_Ddis GTLFITNYRMIWKKDESNSIDSESNSILLPEDIITPTQSFS------------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque -----------------------------------------VFSRAERSKRREPIQRLLK AqueK491_Aque ----------------------------------------P------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ----------------------------------------P------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ---------------------------H-------------------------------- LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ---------------------------N-------------------------------- GbpC_Ddis -----------------------GSGSVPTYNPSDN----R------------------- Pats1_Ddis YNGNGGSGPTNATLSGGGSTSSSSNLNTPITTSP-------IH--TS------------- QkgA_Ddis -----------------------SSPSSPISTSP------PYH--SS------------- QkgA_C2d_Ddis -----------------------SSPSSPISTSP------PYH--SS------------- Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis -------------------------------NHH------HHH--HQ------------- Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis -----------------------EFNN-------NN----C------------------- Roco7_Ddis -----------------------SSTTTPTNNNN------SNN--NT------------- Roco8_Ddis -----------------------ST---NTNSNS-TYNSNSFNKKHHRYSI--------- Roco9_Ddis -----------------------S-----INNNN-NNNSS------KFVEIKLYSFEIIL LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ---------------------------P-------------------------------- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque SKELVLVAC--------------------------------------------------- AqueK491_Aque -----------------------RTPTTPSSHGL------GLHA---------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque -----------------------HTPIS-------------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ---------------------------Q-------------------------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis TSIIKWESFGKSLKSTTPMMSTPTTFQNGGVNRSQFQIFLCYCKNIRFQYMGFSDESNFR LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel -L---------------------------------------------------------- LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele -L---------------------------------------------------------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis -TNSNGAILNPINNSLINSNNNNNNNNINNNINNNINNINNNINNINSNSNNNINSIINS QkgA_Ddis -P---------------------------------------------------------- QkgA_C2d_Ddis -P---------------------------------------------------------- Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis -Q---------------------------------------------------------- Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis -P---------------------------------------------------------- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis DLEKLNLILAYYINPLIDFGRYFSSVN--------------------------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque -T---------------------------------------------------------- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque -P---------------------------------------------------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel -----------------------------------------------------------D LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele -----------------------------------------------------------P GbpC_Ddis -----NSGSH-V-----------------------------------------------I Pats1_Ddis NSNNNNNNNNLNKLSTLDN---TEIPLSMIYRWKMVKTGSLYDSFKIYCKDFRCKIIGFQ QkgA_Ddis -----------------------------------------------------------Q QkgA_C2d_Ddis -----------------------------------------------------------Q Roco10_Ddis -----------------------------------------------------------S Roco11_Ddis -----------------------------------------------------------Q Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis -----------------------------------------------------------N Roco6_Ddis -----NGDMKYL-----------------------------------------------D Roco7_Ddis -----------------------------------------------------------I Roco8_Ddis -----------N-----------------------------------------------E Roco9_Ddis -----------N-----------------------------------------------E LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque -----------------------------------------------------------E AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque -----------------------------------------------------------K AqueK491_Aque -------------RASSGSSSNPLDIM--------------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque -----------------------------------------------------------E LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ----VLTH--GADP---------------ESYA---------VRK--------------- CG5483_Dmel VVQSLLQH--GANP---------------NIVA-----------KPV------------- LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ----VLTH--GADP---------------ENYA---------VRK--------------- T27C10.5_Cele LMTLLLDA--GADV---------------NLPL-----------AVL------------- GbpC_Ddis TSTN-------------------SVISNSSI---SSTGVIN------------------- Pats1_Ddis INSHVLVKF---KD---------------LLTK---------CSVP---TLD-------- QkgA_Ddis LLEHLLHQQ---QP---------------ITSV---------GSKP---SFF-------- QkgA_C2d_Ddis LLEHLLHQQ---QP---------------ITSV---------GSKP---SFF-------- Roco10_Ddis DSQMPLSSS---PTMGYPRGNHNKKTSASA------------------------------ Roco11_Ddis LQQQ-QQQQ---LQ---------------QQMK---------TPKL---LFF-------- Roco4_Ddis ------SQQ---ND---------------NQAV---------PVIP---TFF-------- Roco5_Ddis LYKQIVQVV---KDIVNESVNINKVISIS------------------------------- Roco6_Ddis LSKRMIYSL--------------ELMMIPEIENRFQGDFKS------------------- Roco7_Ddis ISQTIIQNI---N----------------VEHMKDQISQFSISIIN---TIFRSIEKFPP Roco8_Ddis LSKVVLEDL---NT---------------V-TL---------VKDE---LIQ-------- Roco9_Ddis IPRAPLL----------------------------------------------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur --DQLIRH--GHLL---------------------------------------------- LRRKb_Spur -----VEL--GADV---------------NTG---------------------------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque SISALFK----------------------------------------------------- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque -----HNRYLSLCS---------------ESLR--------------------------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque SDNHILEKK---LTY--------------FAST---------GTKP---DMR-------- AqueK491_Aque ------------------------------TEM---------GRT--------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque -----VRI--GADV---------------NSSN--------------------------- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ---PLMQS--MALP---------------SPSA---------SIPPPSSQIR-------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque MAALLLSN--GANP---------------NATL-----------A--------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ----------------------------------------VSSQNRSPL----------- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------KSIKSPTI---------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis TVFQLFEMLYLDIHQVFSPDFCFELMKKIFFTKLICPILAN---LKSPPNMANGKFFTKT Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------PLHE-------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------TI----------------------------FAYNSK---------ESSFG---- QkgA_Ddis ------VII---------------------------NLYNDD---------RQSYM---- QkgA_C2d_Ddis ------VII---------------------------NLYNDD---------RQSYM---- Roco10_Ddis ----------MNSTGVSSSSSGV------------------------------------- Roco11_Ddis ------IVM---------------------------SVG--V---------GKSYI---- Roco4_Ddis ------VVV---------------------------NIG--V---------GPSFV---- Roco5_Ddis --------GLFNSSD-------IVQNRKFLKEGILIEQFNNQ---------RISYYTFLF Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis YIEISKVVL---------------------------DIA---------FDRDQSRR---- Roco8_Ddis ------LSQ---------------------------ELMNGDKGLKLQKKKKGAAG---- Roco9_Ddis ------------------------------------ANNNNSSSNLISLGRSGITN---- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ---------N-TECF--------------------------------------------- QkgA_Ddis ---------SEIVSF--------------------------------------------- QkgA_C2d_Ddis ---------SEIVSF--------------------------------------------- Roco10_Ddis ---KQAGAGEKVMQFLGKMSLSKERMSKLVSQSKEQYKTPSSPYQQSTSSSISSGSGTIS Roco11_Ddis ---------KNIKEE--------------------------------------------- Roco4_Ddis ---------SEIKSA--------------------------------------------- Roco5_Ddis SDIILFTEKIEDTSTI-------------------------------------------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis -GSVTTQEQI-------------------------------------------------- Roco8_Ddis ---------TTISCF--------------------------------------------- Roco9_Ddis ---------TSTANINGSNRNSV------------------------------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------ASR--------------------------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ----------IICSN--------------------------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ---------------------------PDHS----------------------------- QkgA_Ddis ---------------------------AGSF----------------------------- QkgA_C2d_Ddis ---------------------------AGSF----------------------------- Roco10_Ddis GHTSPNSLNSVQVVPF-----------EGI------------------------------ Roco11_Ddis ---------------------------AGTI----------------------------- Roco4_Ddis ---------------------------AGTT----------------------------- Roco5_Ddis --------NNNTMMAY-----------DGSF----------------------------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------M----------------------------- Roco8_Ddis ---------------------------SG-S----------------------------- Roco9_Ddis --------------GGNGSHDYTTNIWDI-YSPLIEGQRLKLDLDKDWRVVEFLSRDTST LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------D----------------------------- AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ---------------------------LGFT----------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ---------------------------NGRL----------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis IYPKRILIPNLIGDELLQSYVRKTQSKIPIFSWSNQNNKSMLFRICVYNQPFNNKFNSGG LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis -----------------HFIKGMIFRNTHSISMTAALNPT----LNNQVIPPSIPLPSKE Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis TLAYNNNSTIINNNSVIITNSSTIGTNTSGIS-------NSNHLIVGEIEPPS-PIKKRQ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis EACNNFI----------NNIRSESSELEESFKRAKD-----------------------L Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ----QQIVDKKDTSSPLS-----------SLRSSKGIPSKSSKKDKQGFLSSSTSSIIPI LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap -----------IMEQK----------------------DQQFL----------------- LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel -------------EDH-------------------------------------------- LRRK2_Mmus -----------VVEQK----------------------DEQFL----------------- LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis -----------LLQEYNRIGVSWDLWRTTTQSKLCEH-YPPTS----------------- QkgA_Ddis ------Q----FIEWR--------------------N--DESW----------------- QkgA_C2d_Ddis ------Q----FIEWR--------------------N--DESW----------------- Roco10_Ddis ----------------------------------------------FGIPLRVILRYPNE Roco11_Ddis ------P----ILEWFT-------------------N-YIRSW----------------- Roco4_Ddis ------Q----FIEWIV-------------------N--DQAS----------------- Roco5_Ddis ------Y----LLK-----------------------K----LERIV-------NIQVDD Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis NTCISFARADRQ------------IYLFSIFKEMLI------------------------ Roco8_Ddis ------Q----LIDWLV-------------------KKLEVTR----------------- Roco9_Ddis QTTISTD----TVDVKL-------------------YNLFVNK----------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------E----AV----E------------------N--YDKY----------------- AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------E----MIEILQE------------------G--GADV----------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------E----AIEGS-----------------------GESH----------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------NLCCKCFAKVA----------------MDDYL--KNV-M--- LRRK1_Hsap ---------------------------N-----------------EFPVI--VRL-P--- CG5483_Dmel ND-------PKCC--------------E-----------------EIYGL--SNV-P--- LRRK2_Mmus ------------------NLCCKCFAKVA----------------VDDEL--KNT-M--- LRRK1_Mmus ---------------------------N-----------------EFPVI--VRL-P--- T27C10.5_Cele DT-------EYSV--------------E-----------------EGRCI--GSG-A--- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis -----------------VV-PKSVS-DNIVVTSAYYRSYGFPVLAWSHPT--QKS-S--- QkgA_Ddis -----------------KE-VFKLS-SNL----------------LTYHV--KKN-E--- QkgA_C2d_Ddis -----------------KE-VFKLS-SNL----------------LTYHV--KKN-E--- Roco10_Ddis S--------GNQIPSILNS-I--------------------------------------- Roco11_Ddis -----------------EE-VFKLT-SNQ----------------VTSHI--KRQ-L--- Roco4_Ddis -----------------KE-VFKVS-TNL----------------LSHHK--KQI-E--- Roco5_Ddis PELGFEYRKGFQIKTKESS-IFYMT-SSEK----------------EK------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis --------------------NFKIS-FNL----------------LNNNQ--NNN-Q--- Roco8_Ddis -----------------KE-SIQIA-SAL----------------MHLNI---FI-E--- Roco9_Ddis -----------------EE-QLQSS-T-----------------------------SSSP LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ----------------------------------------------FEQH--EPN-P--- LRRKb_Spur ------------------------------------------------EG--YET-P--- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ---------------------------------------------EV------------- AqueK486_Aque -----------------------------------------------PHC--LED-T--- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque -------------------------------------------------IRSINYPI--- AqueK489_Aque -----------------SE---------L----------------IIFRI---------- AqueK490_Aque -------------------------------------------------D--IEE-A--- AqueK491_Aque -----------------NA-IMRPS-L-D----------------RSANA--DLT-A--- AqueK492_Aque -----------------------------------------------PHC--LED-A--- AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ----------------------------------------------DPHG--ADS-A--- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ---------------------------T-----------------PFSKL--LLT-P--- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ---------------------------G-----------------EMGGL--AKN-P--- LRRK2_Hsap -----------------------L------------------------------------ LRRK1_Hsap -----------------------L------------------------------------ CG5483_Dmel -----------------------I------------------------------------ LRRK2_Mmus -----------------------L------------------------------------ LRRK1_Mmus -----------------------L------------------------------------ T27C10.5_Cele -----------------------L------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis -----------------------I------------------------------------ QkgA_Ddis -----------------------L------------------------------------ QkgA_C2d_Ddis -----------------------L------------------------------------ Roco10_Ddis -----------------------FTILESSSALSTNRLFYGDYNTSTSNLASSISPISTA Roco11_Ddis -----------------------L------------------------------------ Roco4_Ddis -----------------------L------------------------------------ Roco5_Ddis ---------------STWFQVLSQA----------------------------------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis -----------------------N------------------------------------ Roco8_Ddis -----------------------V-----GT----------------------------- Roco9_Ddis STSLNNSSNNLNKEFQQIHQQMQQ-----NQ----------------------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur -----------------------L------------------------------------ LRRKb_Spur -----------------------M------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque -----------------------L------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque -----------------------F------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque -----------------------L------------------------------------ AqueK491_Aque -----------------------L------------------------------------ AqueK492_Aque -----------------------L------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque -----------------------I------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque -----------------------L------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque -----------------------L------------------------------------ LRRK2_Hsap ---ERA------------------------------------------------------ LRRK1_Hsap ---YAA------------------------------------------------------ CG5483_Dmel ---AEA------------------------------------------------------ LRRK2_Mmus ---ERA------------------------------------------------------ LRRK1_Mmus ---YAA------------------------------------------------------ T27C10.5_Cele ---VEA------------------------------------------------------ GbpC_Ddis ---------------------------------------------NNINNNSNIN----- Pats1_Ddis ---TRATSPEDQNNGSSNYLLTPNSPNSSSSNLANNNNSNNNNINNNNNNNNNNNN--NN QkgA_Ddis ---ARA------------------------------------------------------ QkgA_C2d_Ddis ---ARA------------------------------------------------------ Roco10_Ddis ANTTI-------------------------------------PTISVPTSPNLSSSLSS- Roco11_Ddis ---TKA------------------------------------------------------ Roco4_Ddis ---THA------------------------------------------------------ Roco5_Ddis -SLKS-------------------------------------NQNQNQNQNNLTNSYSS- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ---IN----------------------------------------QNNNNNNNQNC--NS Roco8_Ddis --IFN----------------------------------------SSNNNNNNNNG--GG Roco9_Ddis --LNS-------------------------------------SSNNNNNNNNNNNN--NN LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ---LFA------------------------------------------------------ LRRKb_Spur ---CFA------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ---TAA------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ---LAA------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ---LQA------------------------------------------------------ AqueK491_Aque ---VQA------------------------------------------------------ AqueK492_Aque ---TAA------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ---YQA------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ---AEA------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ---AEA------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------NN---------NSN---NNNNNNN QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis -------------------------------------SSSSGSSGNSSPNIINQLQQQQQ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis -------------------------------------TVAGGRNSTIGL---GGIDDFNN Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis NTSSPIISSRSGFYTLRNSSTNSSPTNPPLTARGNGSI---------SIGNNNNNNNNNN Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------NN---------NNN---NNNNNNN LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis NNNNNNNNNNNNN-----GGGSGSR-------STTIDNGQTSILNKNISNTPLIQSPTPN QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis PQPTTTTTTNTN------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis NNNGNNNGSNND------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis NNNNNNNNNNNNNNSGGGGG---------------------------------------- Roco8_Ddis ------------------------------------G----------------------- Roco9_Ddis NNNNNNNNNNNNN-----KINKRQNEATIVFTNKVGGTSDNHINIISVYEQFK------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis LPPSQHSLNLLMSPQTSSPRIHQS------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------TSPHQYLSQKSIKLEVENICNQYDQGIEVSLKKCNVHVV--- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------DGPDEFEDAKDIALFCKMIISGQ---------RPKVELTSQM Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis --------------SEILIEFFNRLPEPIISVEFYETLLNYYQT---------------- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis LKISDPKPLFAALAS----------------THFVNQLIFIPLTMNDKYMQMTLGMMSLN Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ----------------C------------------------------------------- LRRK1_Hsap ----------------I------------------------------------------- CG5483_Dmel ----------------C------------------------------------------- LRRK2_Mmus ----------------C------------------------------------------- LRRK1_Mmus ----------------I------------------------------------------- T27C10.5_Cele ----------------V------------------------------------------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis -------ISSSSIPQVCQEDIDFLRGILDIKSSSMLNVFDTGSGGSYSSTMIGCQIEFLN QkgA_Ddis ----------------C------------------------------------------- QkgA_C2d_Ddis ----------------C------------------------------------------- Roco10_Ddis ETLLHLMI--RKMNNPNKS----------------------------------------- Roco11_Ddis ----------------C------------------------------------------- Roco4_Ddis ----------------C------------------------------------------- Roco5_Ddis KSITHLTLSQNSINDPCAV----------------------------------------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis --------------------------------------------------MNSSNIIFLS LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ----------------C------------------------------------------- LRRKb_Spur ----------------C------------------------------------------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ----------------V------------------------------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ----------------V------------------------------------------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ----------------V------------------------------------------- AqueK491_Aque ----------------A------------------------------------------- AqueK492_Aque ----------------V------------------------------------------- AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ----------------V------------------------------------------- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ----------------C------------------------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ----------------A------------------------------------------- LRRK2_Hsap ----------------------------------------------------D------- LRRK1_Hsap ----------------------------------------------------K------- CG5483_Dmel ----------------------------------------------------K------- LRRK2_Mmus ----------------------------------------------------D------- LRRK1_Mmus ----------------------------------------------------K------- T27C10.5_Cele ----------------------------------------------------R------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis LPPPNKVRERFNRLL------HLHLGNPDSEWSETIRFFWLDPLKPILSAAIN------- QkgA_Ddis ----------------------------------------------------T------- QkgA_C2d_Ddis ----------------------------------------------------T------- Roco10_Ddis ----------------------------------------------------ILCRLMKY Roco11_Ddis ----------------------------------------------------T------- Roco4_Ddis ----------------------------------------------------T------- Roco5_Ddis ----------------------------------------------------ALGDMLRY Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis IPTREQVEACW---FDLYQSITSFDGSMDA-WKSIEESKWVDSVKLLLEGCV-------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ----------------------------------------------------Q------- LRRKb_Spur ----------------------------------------------------E------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ----------------------------------------------------E------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ----------------------------------------------------R------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ----------------------------------------------------L------- AqueK491_Aque ----------------------------------------------------M------- AqueK492_Aque ----------------------------------------------------E------- AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ----------------------------------------------------S------- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ----------------------------------------------------V------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ----------------------------------------------------I------- LRRK2_Hsap -------------------------------------QNN-------------------- LRRK1_Hsap -------------------------------------SGN-------------------- CG5483_Dmel -------------------------------------QRS-------------------- LRRK2_Mmus -------------------------------------QNN-------------------- LRRK1_Mmus -------------------------------------AGN-------------------- T27C10.5_Cele -------------------------------------SDG-------------------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis -------------------------------------IAM-------------------- QkgA_Ddis -------------------------------------LGD-------------------- QkgA_C2d_Ddis -------------------------------------LGD-------------------- Roco10_Ddis LKD-IMVYTNFNDVTLELLVERFHKFILRPTIGTIAQSKE-------------------- Roco11_Ddis -------------------------------------TGN-------------------- Roco4_Ddis -------------------------------------VGD-------------------- Roco5_Ddis NHSLIQMDLSENTIA---------------------DKGL-------------------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ---------------------------------------GLNNSSNLLINPWVSSYQNSN Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur -------------------------------------GGH-------------------- LRRKb_Spur -------------------------------------NNN-------------------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque -------------------------------------VGN-------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque -------------------------------------DKR-------------------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque -------------------------------------SGA-------------------- AqueK491_Aque -------------------------------------TND-------------------- AqueK492_Aque -------------------------------------VGN-------------------- AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque -------------------------------------ISS-------------------- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque -------------------------------------FNS-------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque -------------------------------------NNN-------------------- LRRK2_Hsap SIMVECLLL-LGA-----------------------D----AN--Q----AKEGSSLICQ LRRK1_Hsap EDIAIFLLR-HGA-----------------------Y----FC--S----Y--------- CG5483_Dmel LAMLDLLLK-HGA-----------------------R----DD--N----G--------- LRRK2_Mmus SIMVECLLL-LGA-----------------------D----AN--Q----VKGATSLIYQ LRRK1_Mmus EDIAIFLLR-HGA-----------------------Y----FC--S----Y--------- T27C10.5_Cele LHIVHFLLD-RGA-----------------------L----DT--D----N--------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis HVDQGRSVL--------------------------------------------------- QkgA_Ddis INLLDEIIL-SGC-----------------------S----KS--Q----L--------- QkgA_C2d_Ddis INLLDEIIL-SGC-----------------------S----KS--Q----L--------- Roco10_Ddis ISESHL------------------------------------------------------ Roco11_Ddis INLLDEILL-SGI-----------------------S----KE--Q----I--------- Roco4_Ddis VNYLDQIIL-SGV-----------------------S----TD--Q----L--------- Roco5_Ddis ISLIDGILS-HPS-----------------ITVVILT----QN--Q----I--------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ISNSDQVQS-TRV------------------VQSFSK----KW----------------- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis --KVSNLLD-EG------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur YSIVADLIE-RGL-----------------------V----SI--D----E--------- LRRKb_Spur VDMVKQLLK-QGI-----------------------S----DL-------H--------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque --LARPLINDHVL-----------------------RFDTAQE--NASFIT--------- AqueK486_Aque QLNVGKLII-KGA-----------------------T----NI--Q-------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque LEVLEMVFS-NQETRPLPDRILSRPYVLGKKTENVPG----EN-------M--------- AqueK489_Aque --ILAPLLQ-NGK-----------------------I----NI--S-------------- AqueK490_Aque DDNIAPLIL-AGA-----------------------R----RL--D----C--------- AqueK491_Aque VKMVRFLLQ-HGA-----------------------T----DA--R----L--------- AqueK492_Aque HFNVGRLVV-KGA-----------------------K----NI--Q-------------- AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque TDVVKVVLE-SRL-----------------------T----NRTLL----K--------- AqueK495_Aque KNILDELQS-MSC-----------------------T----DR--G----V--------- AqueK496_Aque QDIVEILIN-HGA-----------------------K----DL--N----G--------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque PLMIRTLVS-YGA-----------------------E----DR--R----H--------- LRRK2_Hsap VCEKESSPKLVELLLNSGSREQDVRKALT-I--------------S---I---------- LRRK1_Hsap -------------------------I-L-----------------L-------------- CG5483_Dmel -------------------------TAIG-M--------------A---I---------- LRRK2_Mmus VCEKESSPKLVELLLNGGCREQDVRKALT-V--------------S---I---------- LRRK1_Mmus -------------------------I-L-----------------L-------------- T27C10.5_Cele -------------------------KALR-L--------------A---A---------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ----------------------------I-Q--------------N---S-------SSG QkgA_Ddis ----------------------------K-E--------------A---Q---------- QkgA_C2d_Ddis ----------------------------K-E--------------A---Q---------- Roco10_Ddis ----------------------------------KTIKDIV--TMF-------------- Roco11_Ddis ----------------------------K-E--------------T---Q---------- Roco4_Ddis ----------------------------K-E--------------A---H---------- Roco5_Ddis ----------------------------T-DTGAKHI---SKLLKF-------------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis -------------------------------------------------SSVLLKPPIDS LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur -------------------------A-AV-Y--------------M-------------- LRRKb_Spur -------------------------TPLS-R--------------C---L---------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque -------------------------ETME-W--------------A---L---------- AqueK486_Aque -------------------------QALD-D--------------S---K---------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque -------------------------NAVG-V--------------ACECC---------- AqueK489_Aque -------------------------TAIN-V--------------A---M---------- AqueK490_Aque --------------------------ALY-L--------------A---I---------- AqueK491_Aque -------------------------KALT-R--------------A---M---------- AqueK492_Aque -------------------------QALE-D--------------S---K---------- AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque -------------------------DAFV-L--------------A---K---------- AqueK495_Aque -------------------------DKLLDI----------------------------- AqueK496_Aque -------------------------YGCQ-I--------------A---Y---------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque -------------------------DALN-Y--------------A---L---------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis PDIELQL---SSLAQILLDPYYRTMDGFKV-LIEKEWLSYGYPFSKRCHHKTSDD----- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ----------------------------TSDELRPTYLGK-SPKKRSW------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis PLHTLDLASISSLTMVLSDPFYRTLDGFLI-LIEKEWIQYGFPFNNINYHKEQNNLNNNN LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------GK---------------------------- LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------TC---------------------------- LRRK2_Mmus ------------------------------QK---------------------------- LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------QG---------------------------- GbpC_Ddis -------SNTGTT----------------------------------------------- Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis -----------------------------------------------IQQADILFQSPEE Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis -----------------------------------------------NQTLNALFLE-DN Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis -------------------------------------------VMSST------------ Roco9_Ddis GNKENSSSSSSSSSSTSTTPSITKKSSGSISKGSSGIASLINDLDKYD------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------KL---------------------------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------TT---------------------------- AqueK486_Aque ------------------------------RL---------------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------LN---------------------------- AqueK489_Aque ------------------------------TS---------------------------- AqueK490_Aque ------------------------------QQERFKAIAML------------------- AqueK491_Aque ------------------------------RM---------------------------- AqueK492_Aque ------------------------------RL---------------------------- AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------RK---------------------------- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------LI---------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------SQ---------------------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ---------------------------------------------GFSPIFMQF----IF QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis RMNTDDAQILYIEE-VLTSTQKSQHQSS-------------------------------- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis NI-------------------------TQ------------------------------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis -----------LSTTIPSSISLQQLSNQSQSNSNSSSSSSILNLSFTAPISISSTTATMS Roco9_Ddis -----------SNFVLPDT-IHTESQKKKTYLFQDQYESSILVNRSFSPIFVQF----LD LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque -----------------------MVCKAT------------------------------- AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis LVWQIWKEFPTHFQFNEYYLLTLLDNVYNSR--------------------FGTFLCNNY QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis -------------------------------VGNLWLF---------------------- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------SMGAEIIDQWVSCHSTVLSRITLPSIPPEY Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ---------------------------------------------------------SSL Roco9_Ddis AVWQLQRQFPFHFEFNESLLLLLVKESFSGR--------------------FGNFLYSEA LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ---------------------------G-------DSQI-------------------IS LRRK1_Hsap -----------------------------DSPDP----S-------------------KH CG5483_Dmel ---------------------------G-------DEAI-------------------LS LRRK2_Mmus ---------------------------G-------DSQV-------------------IS LRRK1_Mmus -----------------------------DSPEP----S-------------------KH T27C10.5_Cele ---------------------------K-------NEKL-------------------IR GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis KERMENNVYSSTKSFWSFQQQNQS---R-------FTNL------------------FYR QkgA_Ddis ----------------------GA---G-------YTIV-------------------FN QkgA_C2d_Ddis ----------------------GA---G-------YTIV-------------------FN Roco10_Ddis ----------HKQIVWRPKVNIDHGEPD-------LAIL-------------------FS Roco11_Ddis ----------------------TI---G-------HGII-------------------LK Roco4_Ddis ----------------------KA---G-------HAIV-------------------FD Roco5_Ddis SDRIKLKAISVTNRLDKKK----------------------------------------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis SLSTTAATTTTTTTSSSLLNNSSS---G-------SGFLVPTLPASVLNSSSNSNNQLYS Roco9_Ddis LRDSERKFLKRS----------------------------PSIWTFINQNKSTFINLLYK LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur -----------------------------MGAD-----I-------------------LP LRRKb_Spur ---------------------------K-------QHHI-------------------IG LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ---------------------------G-------SANI-------------------LT AqueK486_Aque ---------------------------Q-------KHEA-------------------RA AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ---------------------------G-------DPSV-------------------FD AqueK489_Aque ---------------------------G-------KLSM-------------------AG AqueK490_Aque ----------------------IT---G-------DCQA-------------------IR AqueK491_Aque ---------------------------P-------YHDV-------------------VG AqueK492_Aque ---------------------------Q-------KHEA-------------------RA AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ---------------------------N-------LDPI-------------------IG AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ---------------------------H-------QPSL-------------------VN AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ---------------------------DMTQPNGLKAEV-------------------IP LRRK2_Hsap LLL--------RRLAL------------------D------------------------- LRRK1_Hsap L---------------------------------------L-------RKYFIEASPLPS CG5483_Dmel RLL--------ARRVHPDSD------------------YKINKKGLPT-PVEVN-VFLPS LRRK2_Mmus LLL--------RKLAL------------------D------------------------- LRRK1_Mmus L---------------------------------------L-------RKYFIEASALPS T27C10.5_Cele VFL--------VRLVFADPE------------------YKINKKNIDVGQIQVGQSLLPS GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ----------PS----PS---SSSSSSSSSSS-LSNGY---------------------- QkgA_Ddis ---------------------SYTSYSSGSSL-VVSGT---------------------- QkgA_C2d_Ddis ---------------------SYTSYSSGSSL-VVSGT---------------------- Roco10_Ddis SILKIV----LY----TP---PQSSSSSSSSS-ISNSS-------------SAS----SS Roco11_Ddis ---------------------SLIVNN-LDSI-VVSGS---------------------- Roco4_Ddis ---------------------SLLTHNS-NSL-VVTGT---------------------- Roco5_Ddis ---KQLQVNQKS----TT---PSTSTSTTSST-IINNN---------------------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ----------SS----PL----SLSTSS-----I-------------------------- Roco9_Ddis ----------HS----AN----SSSSSSSTNK-L-------------------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur L---------------------------------------L-------KKWVVPDDSSTN LRRKb_Spur LLL--------YQ-------------M----G-CD------------------------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque HL---------RDLGYEISE------------------DLIRKYDETVGAYLLGE-YPPK AqueK486_Aque MLL--------LVIAA------------------Q------------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque AML--------SH-------------Q----V---------------------------- AqueK489_Aque RIL--------QH---------------------------------------------V- AqueK490_Aque SLI--------SE-PPPVSSSTNWYMSEVHKL-LSQGT---------------------- AqueK491_Aque LLL--------CY-------------N-GSVT-IDSSNMEL-------RKRLGK----AS AqueK492_Aque MLL--------LVIAA------------------Q------------------------- AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque LLL--------KA-------------L----G-LD------------------------- AqueK495_Aque -------------------------------AE-------------------LAYNLDST AqueK496_Aque LIL--------SY-------------Q----CK-------------------LCEQIEDK AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque LLF--------GS-------------L----VKCDEN---A-------TKTLAQSRKEPR LRRK2_Hsap ---------------------------V-ANNSICLGG----F----------------- LRRK1_Hsap -----------------------S-YPGKTALRVKWSH----L----------------- CG5483_Dmel TS----------------NISYSAMFPN-NPTIIDWHSMGSSV----------------- LRRK2_Mmus ---------------------------L-ANNSICLGG----F----------------- LRRK1_Mmus -----------------------S-YPGKIALRVKWSH----L----------------- T27C10.5_Cele -----------------------SLCPS-KAAQLNWNS----A----------------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------N---------------------SSVQHLKCLRVF-- QkgA_Ddis ------------------------M---------------------A------------- QkgA_C2d_Ddis ------------------------M---------------------A------------- Roco10_Ddis -----------------------SSST-PSISSTSLSS-----SLKV------------- Roco11_Ddis ------------------------M---------------------S------------- Roco4_Ddis ------------------------M---------------------A------------- Roco5_Ddis ------------------------KGL-LDLGSCDYSE----ISLQL------------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------P---------------------A------------- Roco9_Ddis ------------------------P---------------------SPISPRQSFI-FKQ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur -----------------------T-DNDKKELIANWHH----K----------------- LRRKb_Spur ---------------------------R-QAGSLTWSS----L----------------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque TLSKFSIIKRPEFSERGEESELDED-DE-PQTIIDT---RPS------------------ AqueK486_Aque ---------------------------T-NDR---------------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque -----------------------S-HH-PSSGIVDWHD----L----------------- AqueK490_Aque ------------------------V---------------------K------------- AqueK491_Aque -----------------------P-SS-PLLLAVNWAS----K----------------- AqueK492_Aque ---------------------------T-NDR---------------------------- AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ---------------------------K-DKSILNIGG----M----------------- AqueK495_Aque ------------------------------------------R----------------- AqueK496_Aque -----------------------P-HPHP-LYTLDWKE----K----------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque -----------------------S-HRHK-MAVVEWNG----L----------------- LRRK2_Hsap -----------------------------------------CIGKVE------------- LRRK1_Hsap -----------------------------------------RLPWVD------------- CG5483_Dmel -----------------------------------------QLSVVR------------- LRRK2_Mmus -----------------------------------------GIGKID------------- LRRK1_Mmus -----------------------------------------KLPWVD------------- T27C10.5_Cele -----------------------------------------NLEQLQ------------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis --------------QDTMWNEYFFRYCFKSSLAIEQFEDRIKLSLLDIEM--TV------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis --LPN-----------------FTVYCSSDTKTVITFSFQSPSTCKLIYAYINS------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis --LN-------------------------------------------------------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ---------------VLDKKN-------------------IKTQII-------------- Roco8_Ddis --FDNRIVEDC------------------------------------------------- Roco9_Ddis EDFNEMIKPSCDNDQIILWSSFFTEFI-------------------------NSRESQQI LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur -----------------------------------------QLNTFD------------- LRRKb_Spur -----------------------------------------GLARLN------------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque -----------------------------------------ELSYID------------- AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque -----------------------------------------KLPYIT------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque -----------------------------------------DLQVIK------------- AqueK495_Aque -----------------------------------------SMETVQ------------- AqueK496_Aque -----------------------------------------HLRIVK------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque -----------------------------------------DMTEFK------------- LRRK2_Hsap ----------------------------PSWLGPLF------------------------ LRRK1_Hsap ----------------------------LDWLIDI------------------------- CG5483_Dmel ----------------------------VPWMVSGVLLL--------------------- LRRK2_Mmus ----------------------------PSWLGPLF------------------------ LRRK1_Mmus ----------------------------LDWLLDI------------------------- T27C10.5_Cele ----------------------------SDWFVAAALHV--------------------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis -------------NSAIT--STANALLP-------FL----------------------- QkgA_Ddis ------------------------LLCA-------IV----------------------- QkgA_C2d_Ddis ------------------------LLCA-------IV----------------------- Roco10_Ddis ---------------VTK---SISQLNR-------------------------------- Roco11_Ddis ------------------------LLGA-------VI----------------------- Roco4_Ddis ------------------------LLGA-------IV----------------------- Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ---------------------------NLHIFL--D------------------------ Roco8_Ddis ---------GNVFYE---FLTKPEAIINHV-----AM----------------------- Roco9_Ddis SKKLIGKVKCDLISQKLTFLSIDRNLLS-------YF----------------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ----------------------------PSWLQGFQDS---------------------- LRRKb_Spur ----------------------------PEWLYKVFLDEE-------------------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ----------------------------PHWLQGHG------------------------ AqueK490_Aque ------------------------MYCP-------IA----------------------- AqueK491_Aque ----------------------------PLWIDMVLIE---------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ----------------------------PSWIYPSLGIRATGRSRGHRRENSLDYVLSGL AqueK495_Aque ----------------------------ENW----------------------------- AqueK496_Aque ----------------------------GDWFFSDLYS---------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ----------------------------PEWFYDSLNT---------------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur --------PPDPDSPNVSGLNETDSGNSSFIASKILMKAETRQQRVKLQEHMAKHDITKM LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque MRRSSTGTSPDK-----DSLDKRDAVDGGGVAN---------------K----------- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur LKWTISTASLPLPLSPGGPRTPGGPRTQHPVPVRRVVSEMQQPPPSASDINPPRWDAESA LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ----------------------------------------EGVAPAAGYGSTPERPSEAE AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur KLQG---------FLRRDDDEILKTHAYYINHSDSDQGGSTATLMPSR------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque DAYKLAKSWDANKF-----------EVYYT-----------SSSPPSSTPSRYVKERQRR AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque LMASRPPSLPTVVCSPVPVVKEPPLSPKQADALVSSDYEQFQGSFPGEGVAKEGGTGEDE AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur -----------------------------------------------------FTSTPRS LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque VDGGGGSGLDSRRGSGLDSRRGSGQDSRRGSVASRDDESCRRVPQRRHTFISKTTTG--- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur HLRPLTIPIGATAATSDTDDEMGDYWRDQPSLGRLPPSEARSS-----------QGLNGR LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque -------------------ASYLPFNTLDL-LQQQGPANLPHSSGACNKMAAEGDTF--- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur RSPIPDGRKSPLLVETLKKNSARSASVSSFFEP-VDETDLAETARRKRFSSGSELPPKAS LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque -------------------------------SPVYVRKTVF------------------- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ----------------NPKL----Q-S--------------------------------- LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ----------------NPRL---------------------------------------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur RLRKKSLSSAQLPILMDDPRWVMHMEQNLGSSIELSESESSLAILPSRPELKKRESIIST LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ----------------VSIM----VK---------------------------------- AqueK491_Aque ----------------APSY----LN---------------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque -----------------------------------------------KNQLSKRQSTPPT AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ----------------LDLDVSLFLNC--------------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ----------------CPLF----V-S--------------------------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------HPR-LNEV---------------------------------------------- LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele --------R-TTRL---------------------------------------------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ----VSTADSSSMYLADESVSVQNLDVSSQDERRLSGNPPGKMFQFQFGGGISSEYA-VS LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque -------------L---------------------------------------------- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque LLINSSQSRSSSPFQSSDEVGVVALG-----------------------GTSKTQYNTLL AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------QPMTFNKL---------------------------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------QSL-TENL---------------------------------------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur DSSTADDFSD-----AGMVSSSIPDVVSQIGVQRPQRMYRNTPQRQKRRSLTAPSNMHDL LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ---------------------------------------------NY------------- AqueK491_Aque ---------------------------------------------KP------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque DSITAMPKDKRSELLSSLIS--------------------STD-----EGADQPDGAAAL AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap --------PDKTSNLRKQTNIASTLARMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDE LRRK1_Hsap --------S--------------------------------------------------- CG5483_Dmel -------AL--------------------------------------------------- LRRK2_Mmus --------PDKSSNLRKQTNTGSVLARKVLRYQMRNTLQEGVASGSDGKFSEDALAKFGE LRRK1_Mmus --------S--------------------------------------------------- T27C10.5_Cele -------SL--------------------------------------------------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur -------TH--------------------------------------------------- LRRKb_Spur --PEGP--D--------------------------------------------------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque -------QL--------------------------------------------------- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque -------IG--------------------------------------------------- AqueK489_Aque --------V--------------------------------------------------- AqueK490_Aque -----DATK--------------------------------------------------- AqueK491_Aque -----KAES--------------------------------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque SPPGGPSGS--------------------------------------------------- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque -------ES--------------------------------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque -------CL--------------------------------------------------- LRRK2_Hsap WTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSN LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus WTFIPDSSMDSVFGQSDDLDSEGSESSFLVKRKSNSISVGEVYRDLALQRCSPNAQRHSN LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque --------------------------------------------DLVLKLFDARIQR--N AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque --------------------------------------------DLVLKLFGVPAQK--N AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap SLGPIFDHEDLLKRKRKILSSDDSLRSSKLQSHMRHSDS-------ISSLASER---EYI LRRK1_Hsap ---------------------------------------------------------CQI CG5483_Dmel ---------------------------------------------------------TAI LRRK2_Mmus SLGPVFDHEDLLRRKRKILSSDESLRSSRLPSHMRQSDS-------SSSLASER---EHI LRRK1_Mmus ---------------------------------------------------------CQI T27C10.5_Cele ---------------------------------------------------------AAI GbpC_Ddis -----------------------------------------------------------T Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ---------------------------------------------------------IIP Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis -----------------------------------------------------------I Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ---------------------------------------------------------RRL Roco9_Ddis ---------------------------------------------------------STL LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ---------------------------------------------------------QVL LRRKb_Spur ---------------------------------------------------------ICI LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ---------------------------------------------------------SKT AqueK486_Aque ASHPMANDDDFSEVQKAVISGRVSTM-VPIEIARRHQNPIVREDLLLRTNVNQEEGSVYW AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ---------------------------------------------------------KQL AqueK489_Aque ---------------------------------------------------------NSF AqueK490_Aque -------------------------------------------ELLLCTDLD-----MRR AqueK491_Aque ---------------------------------------------------------YAL AqueK492_Aque TTHPLANDDDFSEVQKAVISGRVSTV-VPIEIARRHQSSVVREELLLRTDVNQEEGSVYW AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ---------------------------------------------------------FYI AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ---------------------------------------------------------ASI AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ---------------------------------------------------------KFI LRRK2_Hsap TSLDLSANELRDIDALSQ-KC-------CI--SV--H-LEHLEKLELHQNALTSFPQQLC LRRK1_Hsap TELDLSANCLATL------PS-------V--IPW--G-LINLRKLNLSDNHLGELPGVQS CG5483_Dmel TRIDFSHNVLTSI------PQ-------E--L-F--H-LVSLRYLNVAQNKITDLPAPIG LRRK2_Mmus TSLDLSANELKDIDALSQ-KC-------CL--SS--H-LEHLTKLELHQNSLTSFPQQLC LRRK1_Mmus TELDLSANCLPSL------PS-------I--IPW--G-LINLKKLNLSNNQLGELPCVQS T27C10.5_Cele TRVDLSDNRLNTF------PS-------I--L-F--Q-MPSLRSLNLADNSIRKIEIPTY GbpC_Ddis TTISLPNN--TEI------KTALVSTGSQ--N-ASDT-AQIDIEFHLSYTQLVTLPPSIF Pats1_Ddis ETLDLSNLRLYYL------PS-------ESTL-Y--H-LVGLRELNLSKNNLNSISCSLS QkgA_Ddis ---------------------------------------ENGTFLLLSKSNI-------- QkgA_C2d_Ddis ---------------------------------------ENGTFLLLSKSNI-------- Roco10_Ddis QKLDMFSLELESL------PN-------E--I-K--Q-LKDLQELNLNRNKFKLLPGDLA Roco11_Ddis DND---------------------------------N-DKKGSSLILSKLNL-------- Roco4_Ddis EN----------------------------------G-DRKGKRLSLSRSNL-------- Roco5_Ddis --------KLNML------SL-------D--S-R--R-ISDLKELYLDHNCISSIPVSIL Roco6_Ddis SILNLNDNLLGEI------PE-------S--L-K--Q-LTQLISLSIRGNHILEIPLWFP Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis DDLCLTHKCISII------PT-------T--I-I-------------------------- Roco9_Ddis TKLNLSRNYFNTF------PI-------E--I-I--L-LSNLTHLWLQDNRIKSIPSSLL LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur STINLSQNSLFSV------PE-------G--LLW--G-LQNLRRLNLSQNSLQLLPSPKS LRRKb_Spur KFVDLSANNVSDLTPLSRAPH-------R--LLQ--E-FRFLEKLDLSDNGLTEFPKELT LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque HLLQLSDISLTLI------PS-------S--F-F--Q-D--------------------- AqueK486_Aque ----------HGLRLLEL-DL-------SW--IR--K-IHWVKRLRLARNGFRAIPNEIG AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque VNLSLADLGVKEV------PL-------E--L----F-HENLISLSLSGNKLEELPPTKD AqueK489_Aque TYVGLSSNLLKCI------PE-------Q--I-L--R-FNNLQ----------------- AqueK490_Aque KTVDWSRLKLTLL------HH-------SW-V-Y--SIAPWVVNLKLGNNNLRKLPLEFV AqueK491_Aque SQLNISDNKLNEL------PV-------A--I-F--Q-LKNLLRLELNRNNISSLPVSDD AqueK492_Aque ----------HGLRLLVL-DL-------SW--IR--R-IHWVKRLRLARNGFQAIPNEIG AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque KSIDASANQLESLDTLVI--D-------P--IPA--K-LKQLLYVDMKQNKLTGLPEALF AqueK495_Aque ----------------------------------------------------SATPRS-- AqueK496_Aque HIVHLQKNCLQTL------PI-------E--L-F--Q-LPNVAEINVAENSLTSLPDIDS AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque NRLNISKNKLTFV------PI-------E--F-F--R-LQNLTTLNLSHNCLGELPDVVP LRRK2_Hsap -----------ETL---KSL---------------------------------------- LRRK1_Hsap S--------DEIIC---SRL---------------------------------------- CG5483_Dmel Q---------TYGC---PVL---------------------------------------- LRRK2_Mmus -----------ETL---KCL---------------------------------------- LRRK1_Mmus S--------DEIIC---SRL---------------------------------------- T27C10.5_Cele Y----------ISS---TSL---------------------------------------- GbpC_Ddis -----------S------------------------------------------------ Pats1_Ddis -----------SLV----KLEKLSFEENSIT-NLPI------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis -----------RLT----SLRTICIEENNLT-EISS------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis -----------K------------------------------------------------ Roco6_Ddis -----------E------------------------------------------------ Roco7_Ddis -----------------------NYSVCRIV-TVPMNITFQALANRIHTDSEFSDIQLNK Roco8_Ddis -----------NTS---KFLRIIDLSFNQLS-ESNQ----------------------LE Roco9_Ddis -----------KLIGSKLKLQEFDLSHNLLE-SLHK------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur H--------RNLSD---CRL---------------------------------------- LRRKb_Spur -----------DYM---PEL---------------------------------------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ----------LLPL---SSI---------------------------------------- AqueK486_Aque -----------GYL---KQV---------------------------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque -----------WKC---INL---------------------------------------- AqueK489_Aque ---------------------KV------------------------------------- AqueK490_Aque -----------HAT----QLRRL------------------------------------- AqueK491_Aque -----------WEC---DSLEHI------------------------------------- AqueK492_Aque -----------DYL---KQV---------------------------------------- AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque -----------EEL---SQV---------------------------------------- AqueK495_Aque --ALLVLSKFARQCN--KRYEQLHLSYQSISNLLPQ------------------------ AqueK496_Aque DSCTVSTGTNAWKC---SQLTVLILSSNNLS-CLPT------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque MATD--STTPTWPC---GSL---------------------------------------- LRRK2_Hsap --------------------------------------------------THLDLHSNKF LRRK1_Hsap --------------------------------------------------LEIDISSNKL CG5483_Dmel --------------------------------------------------DELFLQDNQL LRRK2_Mmus --------------------------------------------------IHLDLHSNKF LRRK1_Mmus --------------------------------------------------LEIDISSNKL T27C10.5_Cele --------------------------------------------------EILNLRNNQL GbpC_Ddis ----------LI------------------------------------WIQKLVLTHHNI Pats1_Ddis ETVVLLAEK-LT------------------------------------SLTELNLSSNQL QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis EMADFLGTR-LS------------------------------------NLENVTLSSNRL Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis --------E-LK------------------------------------NLQILDLSNNQL Roco6_Ddis --------E-FK------------------------------------LLRKLDVSHNAI Roco7_Ddis EEYEMVIRYPEE------------------------------------SITVLNDEGNQE Roco8_Ddis SI-----AT-LY------------------------------------NLESCNLSHNQL Roco9_Ddis SI-----YT-LS------------------------------------TLTKLVLDNNKL LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur --------------------------------------------------RSLSLYQNEL LRRKb_Spur --------------------------------------------------QELNLRSNGI LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque --------------------------------------------------THVDFSRNLL AqueK486_Aque --------------------------------------------------VKLDLQHNEL AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque --------------------------------------------------TFLSLANNLF AqueK489_Aque -----------------------------------------------------QMHHNRI AqueK490_Aque -----------------------------------------------------DLSCNLL AqueK491_Aque -----------------------------------------------------DMSHNQL AqueK492_Aque --------------------------------------------------VKLDFQRNEL AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque --------------------------------------------------KNLQLGQNCF AqueK495_Aque N------------------------------------------IS-DTLYTHINLSHNNM AqueK496_Aque CL-----WF-LPSLEILKASMNKLESLVPLPEAFNSLIDRDESIVLAPNLREIDLSRNSL AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque --------------------------------------------------NKLDISHNQL LRRK2_Hsap T-SFPS-------------------------------Y-LLK-MSCIANLDVSRNDIGPS LRRK1_Hsap S-HLPP-------------------------------G-FLH-LSKLQKLTASKNCLEKL CG5483_Dmel T-TLPA-------------------------------A-IFH-LPALSILDVSNNKLQQL LRRK2_Mmus T-SFPS-------------------------------F-VLK-MPRITNLDASRNDIGPT LRRK1_Mmus S-HLPP-------------------------------G-FLH-LSKLQKLTASKNYLERL T27C10.5_Cele E-CIAI-------------------------------QFLSS-LPQLQQLDVSKNELSQL GbpC_Ddis K-TLSE-------------------------------D-IGK-LQQLQVLVLENNRLINL Pats1_Ddis I-DLPI-------------------------------E-FSMFSKSLKKLHLKNNRFSAI QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis V-VLPP-------------------------------L-Y-T-WLKLKTLNISNNYLTKL Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis S-SLPS-------------------------------E-ISE-MKELKLLNVSHNNLSSL Roco6_Ddis S-SVPN-------------------------------T-FNK-FSILEDLNLSNNYISYI Roco7_Ddis VICEPELPLWMFDIDTESIIIFRPIKRRSPSSSFNIFL-KF-IFPSNSSFNSSSSSLPST Roco8_Ddis S-TLPS-------------------------------S-FSR-LELLTKLILSHNCFQVI Roco9_Ddis I-IIPE-------------------------------S-ISK-MKQLKCLSVQNNRLSSF LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur L-SVPA-------------------------------E-LFM-LKELEFLSLASNAMEEL LRRKb_Spur T-ELPT-------------------------------H-LLS-LSKLTLLDLSHNQIKDL LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque C-EIPV-------------------------------E-LCQ-LPSLTYLNLSHNFLSSL AqueK486_Aque V-TVPH-------------------------------C-LFE-LPNLN------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque S-VVPP-------------------------------G-LFQ-LPKLTNLNLSSNKLVKI AqueK489_Aque T-DIPH-------------------------------E-LFS-LPRIKDIDLSFNLISAL AqueK490_Aque E-KIEI-------------------------------G-LFS-LPNLEGLNLSQNKLRDL AqueK491_Aque T-SLPP-------------------------------L-LFT-LPELKELCANNNAIRDV AqueK492_Aque V-TVPC-------------------------------C-LFE-LPSLN------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque I-SLPL-------------------------------E-IGL-CSNLVELDLAGNSIAEF AqueK495_Aque K-SVPE-------------------------------E-LFQ-LQRLQYLDLSHNAIEKL AqueK496_Aque K-EIDN-------------------------------F-VFG-LSELSKLNLSQNELQSL AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque K-ELPI-------------------------------Y-LFE-LPQLSILDASHNQLTAL LRRK2_Hsap -----------------VVL----------DPTVK-CPTLKQFNLSYNQLS-----FVPE LRRK1_Hsap -----------------FEEE--------NATNWIGLRKLQELDISDNKLT-----ELPA CG5483_Dmel -----------------PFDL------------WR-APKLRELNVAFNLLR-----DLPV LRRK2_Mmus -----------------VVL----------DPAMK-CPSLKQLNLSYNQLS-----SIPE LRRK1_Mmus -----------------FEEE--------NATNWIGLRKLQELDLADNRLT-----ELPV T27C10.5_Cele -----------------PEYI------------WL-CPALKELNASYNRLS-----TLPM GbpC_Ddis -----------------PQSI-G---------D--------------------------- Pats1_Ddis -----------------PEVL-G---------M---LENLIELDLSELDLSSSTNSGVGI QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis -----------------PIDI-F---------Q---IPTLEVLRVSNNDLD-----DNGI Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis -----------------PIEL-G---------T---LCKLNHLDISFNFIE-----TINV Roco6_Ddis -----------------HPSL-F---------P----EGIMRLNLSNNLFR-----EVEL Roco7_Ddis PHQKINPMILYINPQSTPQSIID---------K---FSKLIQPS---------------- Roco8_Ddis -----------------PNVV-F---------Q--------------------------- Roco9_Ddis -----------------PQAL-S---------L---CVGLEELYVQNNQIR-----ELPL LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur -----------------IQPA-KESTQDEIPRQWN-CMSLVNLDLSQNKLS-----SLPR LRRKb_Spur -----------------NKTR-P-------G--DT-AFKLVELDLSYNATV-----RFPS LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque -----------------PSYA-H----------WG-HTHLKVLNVSHNKLM-----GDA- AqueK486_Aque -----------------------------------------ELNLSNNKLI-----EIPD AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque -----------------GPDL-W-----------R-APLLKYLYASSNLLQ-----SLPY AqueK489_Aque -----------------PSSI-H---------SNV-ANSLQSLNLSNNNLT-----QLPS AqueK490_Aque -----------------PEDT-V---------W--------------------------- AqueK491_Aque -----------------PIEV-W---------K---APKLQKLLLQKNRLE-----SFPS AqueK492_Aque -----------------------------------------ELNLSNNKLI-----EIPY AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque -----------------PQEK-I-----------V-LSHLIKFNLSNNSLT-----VFPI AqueK495_Aque -----------------PSML-----------RWN-CPKLKELNLSTNQLA-----DERR AqueK496_Aque -----------------PDSL------------WD-CITLHQLDVSSNSLS-----SLPR AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque -----------------PVL------------MWS-APKLSSLNCSHNTIQ-----EIPT LRRK2_Hsap NLTD-----------VVEKLEQLILEGN--------------KISGICS-P--------- LRRK1_Hsap LFLH-----------SFKSLNSLNVSRN--------------NLKVFPDP-WA------- CG5483_Dmel PPMQ-----------TSSSLLSLDKL----------------NLQSFEEP-PS------- LRRK2_Mmus NLAQ-----------VVEKLEQLLLEGN--------------KISGICS-P--------- LRRK1_Mmus QFMH-----------SFKSLTSLNVSRN--------------NLKSFPDP-WS------- T27C10.5_Cele VARA-----------SRGERPRLNNSNN--------------NFNT-QSP-TQE------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis P--T-------------------------------------------------------- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis PKIC-------------------------------------------------------- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis NSLS-------------------------------------------------------- Roco6_Ddis PP---------------------------------------------------------- Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis GF-F-------------------------------------------------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur QM-D-----------ACTSLITINLSEN--------------SFNEIPRP-WA------- LRRKb_Spur WLSM-----------FVPSLQRLSLASN--------------KIETIPDKP--------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque VHEW-------------------------------------------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque PELKN----------Q--------------------------------SSPLHAGD---- AqueK489_Aque YF---------------------------------------------------------- AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque PFLS-----------PDSGFGTLEGMSSDGQVLHSSFSVPDS------------------ AqueK492_Aque VHEW-------------------------------------------------------- AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque GLNGD----------QFPALRILMLNSN--------------SISLIEDKD--------- AqueK495_Aque GIIK-----------GA------------------------------------------- AqueK496_Aque CGGLEDIREAALAKSTP---------------GILHL-ATAN--------------TS-- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque NLSY-----------VMENYDIIDIAGANGPPGA-SVTSPTQTLSGLSSP-RSKASTRRV LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap --CP-------------------------------------------------------- CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus --CP-------------------------------------------------------- T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur --CP-------------------------------------------------------- LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque -------------------------------------------LVS-------------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------SLYPHTPVSPPFEAHTPYSGRKDSIHFLQQ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque -----------------------TERRRSH------------------------------ AqueK496_Aque -----AQAVFQNDLDCRESLYQASHRRRSK------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque STDPAGASIVQ--------------SYSDNCFTDDSSRTTDDNMIT-------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ----------------------------------------------LKCCK--------- CG5483_Dmel ------------------------NKPRNVTQQRLTHRNLWSAT--LDI---TDNDMKWQ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ----------------------------------------------LKCCK--------- T27C10.5_Cele -------SNPIVV-----------DDPPNVTSNPLRRQNVWQAS--INL---SKVDD--- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ----------------------------------------------LEILN--------- LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque --------------------------PGSSKKEII-------HSLRYSFVDS---GL--E AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque SYIPHVQSSPVMSQSGITDRRVSLPPPHNIRRSRLR------ELFD-----ATDTDE--D AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------I----------------- AqueK496_Aque ------------------------------------------SS--RS---R---TK--K AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque --------------------------PDKVRQTRLY------DR--LNVCNA---NL--T LRRK2_Hsap ----------------------------LRLKEL----KILNLSKNHIS----------- LRRK1_Hsap ---------ASRNALECLP---D-KMAVFWKNHL----KDVDFSENALK----------- CG5483_Dmel HE-------------QDLG---DGKTAGVGSSQL----SSLNIANNLFT----------- LRRK2_Mmus ----------------------------LSLKEL----KILNLSKNHIP----------- LRRK1_Mmus ---------ASKNALESLP---D-KMAVFWKSHL----RDADFSENSLK----------- T27C10.5_Cele ---------------DSLF---P-DFPVTSSNTL----TTINLSFNKFH----------- GbpC_Ddis ------------------------------LVNL----KRLEVDNNHLV----------- Pats1_Ddis -----------------------------KLSKL----CILNLNQTRIV----------- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis -----------------------------TSTKL----RSLDLRKNHLT----------- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis -----------------------------QLVNL----KVLMMQRNYFN----------- Roco6_Ddis -----------------------------WFESL----LTLDISGNKLK----------- Roco7_Ddis ---------------------------------LLDTAHLGFY----------------- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis -----------------------------KLGSL----RMLDLRNNQITKFKCHKLDDKS LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ---------ISKNMVQSAS---G-DLPKFWHRTL----RFLNLSYNRLT----------- LRRKb_Spur ----------------------------LALQLL----KILDLSNNKLT----------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------SPGL----T--------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque REEDFHV--------------------RGQGFNL----EFLDLSDNKLT----------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------SQ---------------------------- AqueK491_Aque PFDDYEIAGIVDSTTSGNKEGK-------VLFQL----ETLDLSYNELT----------- AqueK492_Aque ------------------------------SPGL----T--------------------- AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ----------------------------LKLKSL----QELHISRNSIV----------- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque KGDDFKIRKLKEEVDSGEG-GDA-GIEMCDYSVL----TRLNLSKNRFK----------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ---------IE---WDALE---G-KQ--EIFDGL----NNLNLSHNEIK----------- LRRK2_Hsap -----------------------------------------SLSENFLEACPKVESFSAR LRRK1_Hsap -----------------------------------------EVPLGLFQ----------- CG5483_Dmel -----------------------------------------SIPAALPC----------- LRRK2_Mmus -----------------------------------------SLPGDFLEACSKVESFSAR LRRK1_Mmus -----------------------------------------EVPLGLFQ----------- T27C10.5_Cele -----------------------------------------TFPFCLAC----------- GbpC_Ddis -----------------------------------------SLCS--------------- Pats1_Ddis -----------------------------------------ELPKEFG------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis -----------------------------------------SIPEGIIN----------- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis -----------------------------------------RLPIEIFT----------- Roco6_Ddis -----------------------------------------HLGN--------------- Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis CFLMNEIIHFRMGPNPLQKLSNQMFEMRSLIHLELTGCSLSTVPLKLLD----------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur -----------------------------------------EIPTAICQ----------- LRRKb_Spur -----------------------------------------TLTPVFLH----------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque -----------------------------------------AVPPGLPC----------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque -----------------------------------------LIPQGLCC----------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque -----------------------------------------ELPFAFLA----------- AqueK495_Aque ------------------------------------------EPTD-PH----------- AqueK496_Aque -----------------------------------------SFPIGLPC----------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque -----------------------------------------VIPSNLPC----------- LRRK2_Hsap MNFLAAMPFLPPSMTI----------------LKLSQNK-F------------------- LRRK1_Hsap ---------L-DALMF----------------LRLQGNQ-L------------------- CG5483_Dmel ---------LAVNLTR----------------LNMSYNS-L------------------- LRRK2_Mmus MNFLAAMPALPSSITS----------------LKLSQNS-F------------------- LRRK1_Mmus ---------L-DALMF----------------LRLQGNQ-L------------------- T27C10.5_Cele ---------TCPRLLI----------------LNMSNNS-M------------------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ---------DLKSLEK----------------LYLDFNS-L------------------- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ----------LVELQV----------------LTLADNQ-I------------------- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ---------RLKSLES----------------FSIAGSPCF------------------- Roco6_Ddis ---------LPFHLVR----------------VSIDDNH-L------------------- Roco7_Ddis -------------LRDIDDESSSPPSIKIPNNNSFAHNK-ISTMDIIECGPRLSYEFSIT Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ---------NLVNLEA----------------LYLNQNK-L------------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ---------L-SSLSE----------------LDLSHNV-L------------------- LRRKb_Spur ---------GCDALEQ----------------LCASNNQ-I------------------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ---------------V----------------LNLSSNE-L------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ---------LAPLLMT----------------LKLNNNS-I------------------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ---------LAPKLLK----------------LHLHHNN-L------------------- AqueK492_Aque ---------------V----------------LDLSSNE-L------------------- AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ---------GLNSLKV----------------LDASRNC-I------------------- AqueK495_Aque ---------SVPQQRV----------------LQLTSHN-L------------------- AqueK496_Aque ---------LAPNLFE----------------LDISDNN-I------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ---------LCPKLTR----------------LDLSHNG-I------------------- LRRK2_Hsap ---------SCIP-----------------------------EAILN------------- LRRK1_Hsap ---------AALP-----------------------------PQEKW------------- CG5483_Dmel ---------RSMG-----------------------------HVTSY------------- LRRK2_Mmus ---------TCIP-----------------------------EAIFS------------- LRRK1_Mmus ---------LSLP-----------------------------PQEKW------------- T27C10.5_Cele ---------TSLP-----------------------------PMACV------------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ---------VTLP-----------------------------HSFRQ------------- QkgA_Ddis ---------TRFP-----------------------------MSIIN------------- QkgA_C2d_Ddis ---------TRFP-----------------------------MSIIN------------- Roco10_Ddis ---------SHLT-----------------------------SDIQ-------------- Roco11_Ddis ---------NLFP-----------------------------KSIIT------------- Roco4_Ddis ---------SRFP-----------------------------MSITQ------------- Roco5_Ddis ---------HPIK-----------------------------QRIYEA------------ Roco6_Ddis ---------ESID-----------------------------H----KVILRNKDLALKF Roco7_Ddis VNGTIQNILIDFD-----------------------------NQIDN------------- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ---------SEIS-----------------------------IDFKR------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ---------RCFP-----------------------------LPGTW------------- LRRKb_Spur ---------DSLPGDLDNILRKLKILKLAKNQLGLPEHPFIPKFVLH------------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ---------SSLP-----------------------------ADI--------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ---------KDFG-----------------------------NISDY------------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ---------SSLG-----------------------------TITDY------------- AqueK492_Aque ---------SSLP-----------------------------ADI--------------- AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ---------EFISGEAAEYTCSLQDLKIGHNKLVEKEHEF-QTFIKT------------- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ---------QVID-----------------------------I-TFL------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ---------SDLA-----------------------------LPRAV------------- LRRK2_Hsap ----------------L--------------------PHLRSLDMSSNDIQY-------- LRRK1_Hsap ---------------TC--------------------RQLKTLDLSRNQLGKNEDGLK-- CG5483_Dmel ----------------P--------------------ATLKQLDLSHNEISCWPSLPRIT LRRK2_Mmus ----------------L--------------------PHLRSLDMSHNNIEC-------- LRRK1_Mmus ---------------TC--------------------TQLKTLDLSRNQLGKNEDGLK-- T27C10.5_Cele ----------------P--------------------AHLRTLDLSYNKIQESFIEA--- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ----------------L--------------------TNLEELSLSFNSMTEL------- QkgA_Ddis ---------------MC--------------------SQLVELDMSNNRITEI------- QkgA_C2d_Ddis ---------------MC--------------------SQLVELDMSNNRITEI------- Roco10_Ddis ---------------KL--------------------TSLTELNLNGNQIQSL------- Roco11_Ddis ---------------AC--------------------FNLAELDLSYNNIKEI------- Roco4_Ddis ---------------MC--------------------THLVELDLSDNKITEL------- Roco5_Ddis ---------------IA--------------------IKATKLDLSDCGLSAL------- Roco6_Ddis NQSFSDIVLERIYQCWY--------------------TGDPVLDLSGLGMCVV------- Roco7_Ddis ---------------VANIFYNIYQHLIELSPRSLSSSSSSSSDINNNNNNNT------- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ----------------L--------------------FKLSVLDLSDNQFTNV------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ---------------SI--------------------RKLQHLNLAYNQLMHREAQPQ-- LRRKb_Spur ----------------L--------------------PLLRDIDLSDNGII--------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ----------------P--------------------TLLKSLNLSGNGGEVAIVR--SR AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque --------------------------------------TLTNLDLSSNFLTSL------- AqueK491_Aque ----------------P--------------------SEIELIDGCHNQLTSAVAPARPR AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ----------------A--------------------LVIQSVDATSNGLL--------- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ----------------P--------------------QILRKLSAKRCSLEKF------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ----------------P--------------------SNLKQLNVSHNDILRLDSYKSRV LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ESDPHLLCYSCV-------QLPEGRDDDYKTAS--------------S-KGSSSSAT--S LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele -SPLHVVCHAVPPTTSNGSMLPKRRN-----SPARQHRSRSKSAVRSQ-RSLSVSRHHAL GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ---------------------------------------------------FSPHGPV-C AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ESLRNLTCAQ--------------------------------------KL-LQFAQET-- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------GNTL-------------------------------------TEGQLNSMRRK-C AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque E---QLPCTN-------------------------------------PKT-LINSGGT-I LRRK2_Hsap ---LP-------GPAHWK------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel FRA-SVLKSVCRHRRHLR------------------------------------------ LRRK2_Mmus ---LP-------GPAHWK------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele IDP-QKEEESCVHKRHDS------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis -------------NNNIELTSSGRILTSNGSKHNSNNSNNSSGSSNISEQNLKRSSGIID Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur --DIP-------PPSEWK------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque LQSTPEKTLHCNHADHIL------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque -----MTPTRCSHRNHRV------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque --SIP-------PPYMWR------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque YYE--RQSNVCLHCSHSQ------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque YRD--PSKPFCSHRSHNH------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis SIINGHSNNNSNNYALALLSNSNFLPMFLPGQSKLQDYCFNVGDELILTEKTFVQLVEVL Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ----------SLNLREL----------------------------LFSHNQISILDLS-- LRRK1_Hsap ---------------------------------------------------TKRIAF--- CG5483_Dmel ----------LEALRTL----------------------------ILADNLLTRIQLSTD LRRK2_Mmus ----------SLNLREL----------------------------IFSKNQISTLDFS-- LRRK1_Mmus ---------------------------------------------------TKRISL--- T27C10.5_Cele ----------LEWLKTL----------------------------QLAGNRLRSISVTNA GbpC_Ddis -------LE--------------------------------------------------- Pats1_Ddis ----PREVCFLINLKKL----------------------------MIEGNQIQFLP---- QkgA_Ddis ----PIEITELKFLKN-------------------------------------------- QkgA_C2d_Ddis ----PIEITELKFLKN-------------------------------------------- Roco10_Ddis ----PPQLL--------------------------------------------------- Roco11_Ddis ----PKEICQLKHLKI-------------------------------------------- Roco4_Ddis ----PKDIQLLKSLRI-------------------------------------------- Roco5_Ddis ----PIEIG--------------------------------------------------- Roco6_Ddis ----PPILG--------------------------------------------------- Roco7_Ddis ATPRRPPIALSSSLSQSNAFNSNVYNSNAYNSNVYNSNPYLSNYNGLSSQSLNSMN---- Roco8_Ddis ----------LSNLEEL----------------------------SLAANQLSSIS---- Roco9_Ddis ----PIHA-MLPSLKKL----------------------------YLHNNQLYNIS---- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ---------------------------------------------------TKQDNP--- LRRKb_Spur ----------SQTLREV----------------------------ILSRNKIKKLTLG-- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque --------------------------------------------------------LSSP AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ----------LSNLQHL----------------------------NLSKNQLKDIMVESD AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ----PSS----------------------------------------------------- AqueK491_Aque ----------LRKLGYL----------------------------KLAHNKLVDVQLFRT AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ----------SRGLKHL----------------------------ILGSNKISSLDLS-- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ----------LQYLQTF----------------------------MLEDNRLKRFQLLKA AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ----------LISLAVL----------------------------DASHNQIADVKLYSP LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ---FTTRGRQ-------------------------------------------------- CG5483_Dmel DAT--------------------------------------------------------- LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ---FTTRGRQ-------------------------------------------------- T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ---KTSPVKKKNTPP--------------------------------------------- LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque SA---------------------------------------------------------- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque APV--------------------------------------------------------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque TER------DHGTDLTSSIDEGRFSRRCKTGGMEMSIMHKDFTKSSFGTPLNNRIKGSSV AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque VLK------RTTRDP--------------------------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque VHLVSDRGGK-------------------------------------------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap -------------------------------------------------RSGTEAASVLE CG5483_Dmel -------------------------------------TLF------NESEDADWSVVGVN LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus -------------------------------------------------RSGTETASMLE T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur --TSPTSPQPRQGVANFYAKLRAQRSPAKIIDANSRSTFYAHSPNG-G-SSRPEQWEKIE LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque -----------------------------------------------------HKKL-GG AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque --------------------------------------SF------------PHGLTPTH AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque SST-------------------------------D---------DGPSSDDKKPDSSSVE AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque -----------------------------------------------T-EDELEFRQNCS AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------IKVTDIPLF---AALA-S-ASGQSQDRVRQ LRRK2_Hsap EK----------------AYLWSRVEKLHLSHN-KL-KEIPPEIG-CLENLTSLDVSYNL LRRK1_Hsap FP----------------AFLSESLEVLCLNDN-HL-DTVPPSVC-LLKSLSELYLGNNP CG5483_Dmel RS----------------KVIFPNLSMLDMTNN-CL-KEIPASLH-ELSSLSVLNISGNV LRRK2_Mmus EN----------------PHVWSRVEKLHLSHN-KL-KEIPPEIG-CLENLTSLDVSYNL LRRK1_Mmus FP----------------AFLSESLEVLCLNDN-HL-DAVPPSVC-LLKNLSELYLGNNP T27C10.5_Cele AS----------------KVLLPALNVMDISDN-KL-LQAPPDVA-RLTLLSMLNLSGNT GbpC_Ddis --------------------RLSKLEVLSVNNN-KL-TLLPTSIA-SLSSLKTLNIKSNP Pats1_Ddis NE----------------ISQLSKLMILNVCKN-KL-DSLPASIG-QLSQLVSLNLNNNS QkgA_Ddis ---------------------------LNLSDN-LI-NDIPLEIC-NLTLLKV------- QkgA_C2d_Ddis ---------------------------LNLSDN-LI-NDIPLEIC-NLTLLKV------- Roco10_Ddis --------------------LLTNLKKLYLDNN-QL-QSISSAIH-RMQSLIELRLTNN- Roco11_Ddis ---------------------------LNMNNN-QL-DDLPLELA-NLTNLKY------- Roco4_Ddis ---------------------------LILRGN-LL-EDIPLEIC-YLGDLKI------- Roco5_Ddis --------------------SISSLIELDLTNN-RI-KDLPPQIG-KLSSLQTLNLSNN- Roco6_Ddis --------------------MLVHLTHLDLSGN-CI-SVLPPELA-NLTELVRLDLSFNI Roco7_Ddis VDGAGGVGGFNGEQNQQQNKVIARVRVIWAGSNSSV-DRLQSFIN-TSQNV---NTTYSG Roco8_Ddis ES----------------IGSLKSLEKLDLSFNKQI-NKIPKELG-LLVRLKSLNVLGSN Roco9_Ddis FN----------------DFNLPLLSELRLDGN-KL-TYVSPSIGTKLLSLTLLNLDRNP LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur FP----------------ECFAHSLYVLKLSHN-AL-EDVPPSVC-KLEALYDLDISCNP LRRKb_Spur DN----------------LKSWSKLERLILSHN-KL-TKVPKELG-QLTLLASLDLSHNR LRRKa_Spur ----------------------------------------------------TLQVDGNI AqueK485_Aque AG----------------TMFFTKLWSIDVSYN-EL-NVCPKWIL-ISRALMHLDLSGNT AqueK486_Aque --------------------VTPSIRTLNISYN-HF-CTVPLSVC-SFMSLQHLNISFNR AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque NQ----------------SLLYPKVQSLILSEN-KL-KRFPVGIH-KLERLGTLDVTDNI AqueK489_Aque --------------------KHSHLRSLDISSN-LF-SSVPDCLT-VMAHLTTLNISSNI AqueK490_Aque -------------------IQHSSLEVLQLSGN-KF-TSVPKTLC-RVRTLTTLDLSSM- AqueK491_Aque VL----------------YCLYPQLSTLDLGHN-KL-RSVPSHIH-LISSLAVLTISHNA AqueK492_Aque --------------------VAPSIRTLNISYN-CF-RTVPLSVC-SFKSLQHLNISFNK AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque DC----------------NKFWPHLERLVLSEN-KL-KELPVDIG-KLKTLTSLDISHNK AqueK495_Aque ------------------YSCVFSLTTVDLSNNPKL-TRLPDWVC-VLPHLVRLNLKGTP AqueK496_Aque AL----------------NLLYPSLEGLDLTSN-CLVGTFNPNIG-RQTQLKWLWLSQNK AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque LA----------------KLACPLLTRLVLHHN-QI-AEVPPSVC-DMTSLNSVDLSWNN LRRK2_Hsap ELRSFPNEMGKLSKIWDL---PLDELH--LN---------FDFKH-------IG--CK-A LRRK1_Hsap GLRELPPELGQLGNLWQL---DTEDL--TIS---------NVPAEI------QKE--G-P CG5483_Dmel NITELPPHLGLLSRLWNL---NTRGC--LLQ---------EPLRSMIE-----SKKHK-T LRRK2_Mmus ELRSFPNEMGKLSKIWDL---PLDGLH--LN---------FDFKH-------VG--CK-A LRRK1_Mmus GLRELPPELGQLGNLWQL---DIEDL--NIS---------NVPAEV------RKE--G-P T27C10.5_Cele AIKELPPDYGMLSRLWSL---SLKGC--SLK---------EPLESMVN-----VENCK-T GbpC_Ddis -----------------------------II---------TPPST------VV--SKG-L Pats1_Ddis QLVSLRPTMGLLSNLVEL---KLDGTR--LK---------TPPPE------IV--SLG-L QkgA_Ddis -----------------L---LLNENP--LN---------NFPSS------IV--ELG-T QkgA_C2d_Ddis -----------------L---LLNENP--LN---------NFPSS------IV--ELG-T Roco10_Ddis NISRLPPGIVALKKLNSL---ELTGNKP-LK--------DNIPEK------YI--QKG-K Roco11_Ddis -----------------L---AVQDNP--LN---------KFPHH------II--EQG-T Roco4_Ddis -----------------L---ELQENP--LN---------NFPLS------VV--QSG-T Roco5_Ddis AIESLPWQLSQLTTLKVL---NITGNP--ISFDGASNAKISIPDV------LS--GDD-L Roco6_Ddis -LTTLPLYIVSYKRLEHL---DLQGTLDTLV---------SPPRR------IA--ETGKL Roco7_Ddis STMALNDVLSNPNQLLST--------P--LS---------RPLLS-----------TV-I Roco8_Ddis KINELPSFLSTLPLLEQL---DFSRDI--IK---------SPPKE------IT--SKG-F Roco9_Ddis QITTLPHTLALLKKLKSL---IVNSNI--ME---------SPFRE------L----ET-T LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur DLHKLPEALSTLKHLFHL---KIEGL--DIK---------IP-SDVSQLSPQERS--K-T LRRKb_Spur SITTIPDELGQLNKLWEF---PLDGL--KLD---------LDP--A-----ILK--GR-T LRRKa_Spur NITTLPPEMGRLKCLYDF---NADGC--QLV---------EPLSSMI-----KT--SL-V AqueK485_Aque KIKSLPPELGLMSHLHTL---LFNGL--TLS---------DPPDPIP--------SLG-T AqueK486_Aque NIRSLPVEMGRLQNLIKL---VIDGLK--LR---------DPPRN-------VQ--RD-A AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque TIQSLPEKLHLLKNLIGF---RYKGI--G-----------DPIIGTL----DTF--KD-T AqueK489_Aque GIEIIPYELGNLRHLTFI---GMHRL--PY------------IK-N-----IPT--AN-K AqueK490_Aque PISSLPKEIEMLDKLANL---NVTDCN--IS---------DLPAG------A---LPG-R AqueK491_Aque SIDTLPLELSNLEGLWSL---EYDGV--PLT---------NPPASD-----LDK-FRS-A AqueK492_Aque NICSLPVEMGRLQNLIKL---VTDGLK-DLS---------DPPRN-------MQ--RD-A AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque DIRHLPNEMGKLDFLFYL---NLQGL--KNL----------D---I-----DQT--QN-A AqueK495_Aque KLQELPKALANFKDLSFI---SVDPQ--NFL---------SPPAKV------CS--QG-S AqueK496_Aque ELEKLPLHLADLKNFRRLTEIKLRNL-PSLV---------EPPKEY------QNESVQ-A AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque -IIELRPSLGKLGNLWEF---PLDGL--QLI---------SPPHNI------IDR-GK-T LRRK2_Hsap KDIIRFLQQRLK--KAVPYNRMKLMIVGNTGSG--KTTLLQQLMKTK------------- LRRK1_Hsap KAMLSYLRAQLR--KAEKCKLMKMIIVGPPRQG--KSTLLEILQTGR------------- CG5483_Dmel MDIVGYLKSIYE--DAQPYARMKLMVVGVAGIG--KSTLLDLLRQGA------------- LRRK2_Mmus KDIIRFLQQRLK--KAVPYNRMKLMIVGNTGSG--KTTLLQQLMKMK------------- LRRK1_Mmus KATLSFLRAQLR--KAEKCKLMKMILVGPPRQG--KSTLLEILQTGK------------- T27C10.5_Cele VEIVAYLKTILE--ESKTYHHLRLMILGSDGVG--KSVIWDALCKEA------------- GbpC_Ddis KDIVSFLRELET--GARPCLRSKLVVLGDPGVG--KTSVVQCMKGKK------------- Pats1_Ddis KSILLYLKDLIK--GQEQCYKMKLMIVGQENVG--KTTLLKTLKEKK------------- QkgA_Ddis KKLLSFCRNILEGKSCETWNKVKLMFVGEEGVG--KTRLCKLLIGSK------------- QkgA_C2d_Ddis KKLLSFCRNILEGKSCETWNKVKLMFVGEEGVG--KTRLCKLLIGSK------------- Roco10_Ddis EGIFSFFSETMR--TNVPCYRTRIIMLGDKSTG--KSNLIKCLKKLP------------- Roco11_Ddis KRTLVFLKNIIEGKKSETWNKVKLMFVGQEGVG--KSSLCKALMGSR------------- Roco4_Ddis KNLLLFCKNILERKKSETWNKVKLMFVGQEGVG--KTSLCQALKGSK------------- Roco5_Ddis IGILKYLKLAST--KEKPCMRMKLMLVGQENVG--KTSIAKCLKKEI------------- Roco6_Ddis IDIQRYFHDLFQ---GEPSYRVKLMIVGQENVG--KTSLVKCLKMKK------------- Roco7_Ddis AQDNTYICTS--KNDYCMNNQVKLCIVGEESQE--KLSFYNSLRKNY------------- Roco8_Ddis THIIGYLKDLFE--GTETLSHIKLMVLGSEKTG--RSSLVKALTKSQ------------- Roco9_Ddis DAILRYLTLQMQ--QSQFHPRNKLIIISDITNPQIKNEFIKNLTIAKPLTSKEREKEKEK LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur GQILKILHEKLL--DSQPYHSMKLMIMGPAKSG--KTTLLGSLMNDT------------- LRRKb_Spur KDIIGFLNQKYK--RSEAYNRMKLMVVGYGGRG--KSTLLSRMQGQK------------- LRRKa_Spur KDVLGYLRSILD--DAKPYTRMKLMFVGKAGIG--KTTLLNELRRDG------------- AqueK485_Aque QAILSYLHYKHK--SSQPITSLRVVLVGPESVG--KTSLVARLKGDP------------- AqueK486_Aque RDCVRYLNSKLR--STRRFYRMKLMLVGKQNRG--KTTLVTRLQGLD------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque AQLLYYLRAREL--QAVSNTSMRLFVIGHANKG--KSTVLKTLRGER------------- AqueK489_Aque SSPLEFLKSRAR--TIQTITHYDVMVVSASNTS--PHIV-EAVYNA-------------- AqueK490_Aque GWVRGFVKSRSR--SSKPCNIVKLIILSNSSVG--KVVLFSRLRQVI------------- AqueK491_Aque SDKLLYMRSLLH--DAKPYESMKLMLVGLQKQG--KTTLLTRLREIN------------- AqueK492_Aque RDCVRYLNNKLR--SARRFYQMKLMLLGKQNCG--KTTLVARLQGLD------------- AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque RAIIRYLKAKLT--QSKPCHVMKLTVVGSAAKG--KTTLLHNIINDK------------- AqueK495_Aque AAIIAYLRSQLR--GLSAYRHMNIMLLGWGD-E--KNKIAKELTSQQ------------- AqueK496_Aque SQLLTYMRSRLK--DSVPYRTLKLFFIGCGQRG--KTTLLRRLRERQ------------- AqueK497_Aque --------------TA-------------------------------------------- AqueK498_Aque KDIIGFLWSLLQ--RARPYHRMKLMLVGKAGRG--KTTLLRKISEKG------------- LRRK2_Hsap --KSDL------------------------------------------------------ LRRK1_Hsap --APQV-VH--------------------------------------------------- CG5483_Dmel --GSGS-SS--SSH--R-SRASENHWAKRMGHARSTSRS--H----------------RH LRRK2_Mmus --KPEL------------------------------------------------------ LRRK1_Mmus --APQL-AH--------------------------------------------------- T27C10.5_Cele --VQKR-QP--------------------------------------------------- GbpC_Ddis --KKTN-VT--S------SS--I------------------------------------- Pats1_Ddis --KKAT-P---------------------------------------------------- QkgA_Ddis --YNKK-KS--SS----SSSSSLSSLSSALSSSSSSSSIINSNSIS--NSNINMVNIKNE QkgA_C2d_Ddis --YNKK-KS--SS----SSSSSLSSLSSALSSSSSSSSIINSNSIS--NSNINMVNIKNE Roco10_Ddis --KSSF-SS--S-------SSNLPSLNNLN-----------S-----------------N Roco11_Ddis --RRSS-SS---------FAAE-------------------------------------- Roco4_Ddis --KKKA-EL--Q------------------------------------------------ Roco5_Ddis --IPVG-KKLRQTIGLGTKKSKTPTLTEANGSIDFNAPQ--S----------------IN Roco6_Ddis --KFSK-NS---------DH--L------------------------------------- Roco7_Ddis --SQNG-L---LS----S-GGG---RGGGFFGS----NF-----IPSSTS---------- Roco8_Ddis --TKSL-SR---------QSANF------------------------------------- Roco9_Ddis EKEKEK-EK---------KHKNI------------------------------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur --SGRV------------------------------------------------------ LRRKb_Spur --FDKK------------------------------------------------------ LRRKa_Spur --VGAYIAQ--SL-----GTFG-ERQG----NSHI-----------------------SG AqueK485_Aque --VDG------------------------------------------------------- AqueK486_Aque --V--------------------------------------------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque --MTKE-N----L-----GV---------------------------------------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque --CPHG-SH--------------------------------------------------- AqueK491_Aque --EVRT-PI--STF--NERK-EGETVSAAV---S-----LKPGGITGASS------FFRR AqueK492_Aque --V--------------------------------------------------------- AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque --STKI------------------------------------------------------ AqueK495_Aque --KRQT-QS--------------------------------------------------- AqueK496_Aque --AGET-ER--------------------------------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque --QSGI-QE--NL-----FL---TRMS-------------------------------SD LRRK2_Hsap ----GMQSATVGIDVKD----------------------------WPIQIR--------- LRRK1_Hsap --------GEATIRTTK----------------------------WELQRP--------- CG5483_Dmel SSASSANISTVGVDIGT----------------------------WICEKR--------- LRRK2_Mmus ----GMQGATVGIDVRD----------------------------WSIQIR--------- LRRK1_Mmus --------SEATIRTTK----------------------------WELQRP--------- T27C10.5_Cele -----IHSETGVIRQAE----------------------------WKFEAK--------- GbpC_Ddis -NIGGSSGSEVGIEIDQ----------------------------YDFDVV--------- Pats1_Ddis ---SGPNISTDGIAIDQ----------------------------WVFSCLFE------- QkgA_Ddis NQVTGDTVSTEGVNIH-------------------------------------------- QkgA_C2d_Ddis NQVTGDTVSTEGVNIH-------------------------------------------- Roco10_Ddis NSNNSGNSKTNILDIQD----------------------------WQCPIN--------- Roco11_Ddis LQKSGDTISTEGVKIQ-------------------------------------------- Roco4_Ddis --VTGDTVSTEGVKIQ-------------------------------------------- Roco5_Ddis PLNTSLNISTDGINMDD----------------------------WRPP----------- Roco6_Ddis ----GTNVSTDGIDIDE----------------------------IKFNLD-----IELP Roco7_Ddis --NVNEVSSIDGVLHT-------------------------------------------- Roco8_Ddis -L---KKVTSSEVSLND-----------------PIE-----IIQLKLDLPPEQQNG--- Roco9_Ddis -GYGSKDKDKKGININYQQQHQQQQQYQQHQYSSQIGFNQNLPIKWEIDYENYPNSA--- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur --------LDMALHVTE----------------------------WELQDPVI------- LRRKb_Spur ----GDNIATVGVVVKE----------------------------WVIQI---------- LRRKa_Spur KTLKGNHLSTVGVDVCE----------------------------WTYNK---------- AqueK485_Aque ------INPTKGLEVSE----------------------------WKYKGD--------- AqueK486_Aque ----SINQSTVGVDVSE----------------------------WHYAGG--------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque --MEEKRGVTVGIDVGR----------------------------WTCVHT--------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ---------LPEMDFFQ----------------------------WHYR----------- AqueK491_Aque IGSRDAPLSTVGVDLGL----------------------------WKYRKDLE------- AqueK492_Aque ----GINQSTVGVDVSK----------------------------WHYAGG--------- AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque -----ENTATLGVQIRK----------------------------WTYQQR--------- AqueK495_Aque --------SLSSIERGS----------------------------YDYKGE--------- AqueK496_Aque ---------TEGIDIEE----------------------------WSCRGA--------- AqueK497_Aque -------QPIEGVDITV----------------------------W-------------- AqueK498_Aque AKKFQKDLSTVGIVVSD----------------------------WTYTTK--------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis SNPSSNSLISNSLSNSSISSNNINSNNNINVHSNGGGINSNGVNSNSQININSSSGNIHS Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis NGGGVGNVNSSGGIHSNNSSGGGGGSNSFLNNTNSNGTNNNSSNLNINTNSNNVNSSGGG Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis -------------------------------------IMTSSSNLNLSTGT--------- Roco9_Ddis -------------------------------------LYNLASTIHCTNSF--------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel -----------------------------------------------------------K LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele -----------------------------------------------------------R GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis --------------ELDE--------------------------TS-------------- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis NNYHPPVGTNTSMSNIQ--VIGSSGSNLGSGSNLSIGGSNGNNNNN-------------- Roco7_Ddis ---------------------------------------------S-------------- Roco8_Ddis --LPPPTQLSSSTSELKPQRKDSFGSS-----------------MT-------------- Roco9_Ddis --ISQPIMISSSNQECTKLNKEEFLN------------------SR-------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ---------------------------------------------EGRGCSLTQKVKEKF LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque -----------------------------------------------------------L AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque --------------------------------------------PS-------------- AqueK492_Aque -----------------------------------------------------------L AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque -----------------------------------------------------------T AqueK496_Aque -----------------------------------------------------------K AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque -----------------------------------------------------------H LRRK2_Hsap -----DKRKRDLVLNVWDFA--GR------------------EEFYSTHPHFMTQRALYL LRRK1_Hsap --AGSRAKVESVEFNVWDIG--GP------------------ASMATVNQCFFTDKALYV CG5483_Dmel ---RAPGSHGPVVFRTWDFG--GQ------------------KEYYATHQYFLSKRSLYL LRRK2_Mmus -----GKRRKDLVLNVWDFA--GR------------------EEFYSTHPHFMTQRALYL LRRK1_Mmus --AGSKAKVESVEFNVWDIG--GP------------------ASMATVNQCFFTDKALYV T27C10.5_Cele --SKGDKNLGPVGFSVIDFG--GQ------------------REYHSTHQYFLSKRSLNL GbpC_Ddis -FDEDDKKRRVITLSTWDIA--NQ------------------DVYFASSQLFDSERSVYI Pats1_Ddis QNGRLIKKKQDITLSIWDFA--GQ------------------EIYYTTHQFFLSERSVYI QkgA_Ddis -----DFKSKKVEFYAWDFG--GQ------------------QIFYPTHQFFLTTQSLYL QkgA_C2d_Ddis -----DFKSKKVEFYAWDFG--GQ------------------QIFYPTHQFFLTTQSLYL Roco10_Ddis VDGPDGKKKKTITIHLWEFE--GM------------------QND-ISH-VFFVPNIIYT Roco11_Ddis -----SIKGKKIDFYAWDFG--GQ------------------QVFYPTHQFFLTNQALYL Roco4_Ddis -----NIKNKKVEFHAWDFG--GQ------------------QVFYPTHQFFLTTHALYL Roco5_Ddis ----SEDQSPPVTFSIWDFA--GQ------------------EVYYSTHQFFISSRSVFI Roco6_Ddis SGGSGTMVNQRVTMSIWDCA--GQ------------------ELYYTSHQMFLTDSALYV Roco7_Ddis ELVVGSAEIDQITLKTFYIS--GN------------------EQYQVVHPLFISPQSLFI Roco8_Ddis TPEKKRPTKRNVKLMIYDFRMPSI------------------DVYYHTHQFFLSERAFYL Roco9_Ddis FNTQEISKKKNLTIFIRDLSQLNSSGSASASGNGSGNGNGIGISNTNCSQHLFSKRAVYC LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur SKEKEIVEGPAITFFSWDMK--GG------------------DLYENVHQCFVTAKTLYL LRRKb_Spur -------RKKDFCLSTWDFA--GQ------------------EDFYSTHPCFLTDHAADF LRRKa_Spur ----KKAKHGKVTFSTWDFG--GQ------------------QEFYATHQYFLTKRSLYL AqueK485_Aque -----VLRRNMVTFDLWDFT--GS------------------SRYKSVYSCFDCKDSLHI AqueK486_Aque -----G--RRKYQFSIWDFG--GV------------------EKYYATHQCFLSERSMYL AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ----RKKSAKPINFYTWDFA--GQ------------------DEYYVTHQCFLTNRALYL AqueK489_Aque ----IDRQSKRKHYSCLQFD--DD------------------AQFQIFQQFMSLPSSIYV AqueK490_Aque --PFKFFGIQKLIFNTWMVG--VQ------------------KDYRMLYPCLYTANALYT AqueK491_Aque YRGKKSVPLRSVTFYTWDFG--GQ------------------EEYYATHQCFLSNRSLYL AqueK492_Aque -----GRKKIEYQFSIWDFG--GQ------------------EEYCAIYQCFLSERSMYL AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque -------PGVQYSINCWDFA--GQ------------------EEFYSTHQCFLTPRTIYI AqueK495_Aque ----LDRNVVKVTYHTINFS--SE------------------AMEFTLYQCFLISRCIYL AqueK496_Aque -RRLFRAPQEPIQFLAWDFA--GQ------------------EVYQVTHQCFYSRRAIYL AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque HSDQTQTGLRNITFMTWDFG--GQ------------------EEYYATHQCFLSRRSLYL LRRK2_Hsap AVYDLSKG---QAEVDAMKPWLFNIKARAS-SS--PVILVGTHLDVSDEKQR-K--ACMS LRRK1_Hsap VVWNLALG---EEAVANLQFWLLNIEAKAP-NA--VVLVVGTHLDLIEAKFRVE--RIA- CG5483_Dmel VLWRISDG---HKGLAELLQWLGNIQARAP-NS--PVIIVGTHFDAVGESISP---QKAE LRRK2_Mmus AVYDLSKG---QAEVDAMKPWLFNIKARAS-SS--PVILVGTHLDVSDEKQR-K--ACIS LRRK1_Mmus VVWNLALG---EEAVANLQFWLLNIEAKAP-NA--VVLVVGTHLDLIEAKFRVE--RIA- T27C10.5_Cele VLWKITDG---DEALAQLDTWLVNIHARAP-NS--TVILVGTNLDQVASNSSKFGPGYID GbpC_Ddis VVFNLNND----D-FSAIEYWLHCIMSTSP-NS--PIVLVGTHIDAFENL-NV----VN- Pats1_Ddis VAWNCALA----EEESRVEFWLQSITTRAK-DA--PIIIVGTHLDDVNRTTA-K--MQK- QkgA_Ddis LIFRVNDS----NFAERVNYWVHQIKAKSG-ISLPIIFFVGTHIDSCTPEQL-S--MAE- QkgA_C2d_Ddis LIFRVNDS----NFAERVNYWVHQIKAKSG-ISLPIIFFVGTHIDSCTPEQL-S--MAE- Roco10_Ddis VCFNLSKFGSSKSNEQKITSYLHGINNYDK-KA--TIIIIGTHLDEISSNSK-K--QVD- Roco11_Ddis LVFKLTDP----NFAERVNYWTLQIKANSG-LSVPMIFLVGTHCDACTPEQL-S--SAE- Roco4_Ddis VVFKLTDP----NFAERVNYWVRQVKSNSS-GAVPAIFLVGTHSDVCTPEQL-Q--EAE- Roco5_Ddis VVFDMSVYNP--DETSRVPYWLQCIEAFGG-NS--PVILVGTHLDDLPNGVD-----VN- Roco6_Ddis VVWNLCKP----EVNSRVEFWLHSIRSKAE-NA--PILLIGTHLDDYLATHSES--ELD- Roco7_Ddis ITYNPMNI----NS-TMINYWLEIIQTKAQ-GS--TVYLVGLSNTSIDEKKF-V--SFK- Roco8_Ddis VTYDINKD----LSHSGLEFWVESIKKKAP-NA--PIYIVATHIDTFNQYGG-D--ILV- Roco9_Ddis LVWALSES----EEPTRIYKWLESIRDRCT-FA--TVFIVGLYNSDYCQDVPKD--YYT- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur LVWDMSEG---MDGAHKLSSLLLNISSRSS-DF--GIVIVGTHHDVVQNSPV-D--MID- LRRKb_Spur IS--------------DMEMRVLEVC-R-------------------SPG---------- LRRKa_Spur VVCKITDG---SKVINELQQWLVNIQARAP-NS--PVIIVGTHYDVILRDKKY---SKE- AqueK485_Aque AVFNINTG---Y---SEIISWLSDIQSFSEERV--PVLLVFTHLDSCQTREVRE------ AqueK486_Aque LLWNVQHG---EEGIQELKPWLDAIALRAP-RS--CVLIVGTHLDCVEESDR-P--EV-D AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque LVWKLTDK---EQGLEGLHVWLRNIQ----------VLIIGTHLNAFRRAERG---NAD- AqueK489_Aque ILYDIGNP---SSLY----SVLSHLFLYSS-SP--TVIIAACSTDPFINDDHVK--MLEH AqueK490_Aque LVWDLTKT----GDINNIKLYVNSISRHFP-MA--NVLVIAILPEPYETWA-ES--NMP- AqueK491_Aque VIFNVCDG---EDGIDSLELWLHNIQARAP-ES--PVIIVGTHSDLLKE-DKEQ--RKQ- AqueK492_Aque LAWNVQDG---EEGIQELKPWLDNIALRAP-RS--CVLIVGTHLDSVEEGDR-P--EV-D AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque LAYNISKA---ESELDGLVPWLMNIEARAP-GS--PVIVVGTHRDMIADG---------- AqueK495_Aque CIWNLSDG---KEGLQRLVPVLRNIQSMLP-GS--RVLFVIVHSEEKPELML-N--QIL- AqueK496_Aque ALFRMIDG---EEGINELEPWLRNVQLRAE-GC--IVIIVGTYLDKVSDSKV-A--EID- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque VVWNVTHG---REGVLELKPWLLNIQARAP-NS--PVIIVGTHYDKVKRSQRH---LVT- LRRK2_Hsap KITK----ELLNK----------------------------------------------- LRRK1_Hsap T----LRAYVLALCRS-----PSGSRA--------------------------------- CG5483_Dmel QLQQLIREKFIAIP---------DAEK--------------------------------- LRRK2_Mmus KITK----ELLNK----------------------------------------------- LRRK1_Mmus T----LRAYVLALCRS-----PSGSRA--------------------------------- T27C10.5_Cele IMEQKVRTRYMVA----------DADK--------------------------------- GbpC_Ddis AVLESVASRFQ------------------------------------------------- Pats1_Ddis K---RMKEKYL------------------------------------------------- QkgA_Ddis S---ILKSN-F------------------------------------------------- QkgA_C2d_Ddis S---ILKSN-F------------------------------------------------- Roco10_Ddis KVFDCLSLKYK------------------------------------------------- Roco11_Ddis Q---ILKEN-F------------------------------------------------- Roco4_Ddis S---ILKAN-F------------------------------------------------- Roco5_Ddis QITQDIHSKYF------------------------------------------------- Roco6_Ddis EILENIYSKYF------------------------------------------------- Roco7_Ddis S---EYHR--L------------------------------------------------- Roco8_Ddis PLN-EIDQYLT------------------------------------------------- Roco9_Ddis FITPKIEQKCH------------------------------------------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur -----LRSQLVEMLN----------VG--------------------------------- LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur Y-WPELKRTIFDRFIN-----IAHPQD--------------------------------- AqueK485_Aque -SEKKSRSEWVKYN---------MSISKKPETSPAFTLLASSMSQTVKSLQDIDGRSSAH AqueK486_Aque KLLG----KVAELA---------------------------------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque SLLEGYKERIKKEFQY---------RD--------------------------------- AqueK489_Aque QIKHSNWKQYR---------------E--------------------------------- AqueK490_Aque QLNKKVHNLFS------------------------------------------------- AqueK491_Aque ELT-NYLEKLR---------------D--------------------------------- AqueK492_Aque KLLE----KVAELV---------------------------------------------- AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque SW----ESEVLGVPEPISLYDETYSSS--------------------------------- AqueK496_Aque KI---IKQKFF------------TKSS--------------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque E----NVELINRLYGS---GSRLMHRQ--------------------------------- LRRK2_Hsap -----------------RGFP---A-IR--DYH-FV------------------------ LRRK1_Hsap -----------------TGFP---D-ITFKHLH-EI------------------------ CG5483_Dmel -----------------IGLP---R-VI--DSI-EI------------------------ LRRK2_Mmus -----------------RGFP---T-IR--DYH-FV------------------------ LRRK1_Mmus -----------------TGFP---D-ITFKHLH-EI------------------------ T27C10.5_Cele -----------------SGLP---R-IV--DVI-LI------------------------ GbpC_Ddis -----------------KRFT---N-IQ--AII-SV------------------------ Pats1_Ddis -----------------IRYQ---N-IK--AIK-LV------------------------ QkgA_Ddis -----------------IKYS---R-VKQNVIN-FV------------------------ QkgA_C2d_Ddis -----------------IKYS---R-VKQNVIN-FV------------------------ Roco10_Ddis -----------------QLFP---T-LN--LVFHAV------------------------ Roco11_Ddis -----------------VKYS---R-IRQNAIS-FV------------------------ Roco4_Ddis -----------------VKYS---R-VKENTIN-FV------------------------ Roco5_Ddis -----------------TKFP---N-VK--FFL-PV------------------------ Roco6_Ddis -----------------RKF----R-LK--GIS-IL------------------------ Roco7_Ddis -----------------FRFN---N-IN--SYS-NI------------------------ Roco8_Ddis -----------------QRSL---E-VTG--VI-GV------------------------ Roco9_Ddis -----------------NLFP---N-FTFS-FI-NILNNNNNNNNNNNNNNNNNNNNSGG LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur -----------------PGFP---P-VAG--IV-EV------------------------ LRRKb_Spur -------------------FP---T-IKG--YI-NL------------------------ LRRKa_Spur -----------------AGLP---H-VIA--CV-EV------------------------ AqueK485_Aque ERIQSSLDQMEFSGHIVPLMP---LVIT--EPH-FV------------------------ AqueK486_Aque -----------------QTYQNKLL-VP--EVL-AV------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque -----------------KIAP---K-IRG--VF-YV------------------------ AqueK489_Aque --------------------------RV--TIA-TI------------------------ AqueK490_Aque -----------------QR-----S-IRFHGLL-TL------------------------ AqueK491_Aque -----------------LGLP---Q-IK--EVR-FV------------------------ AqueK492_Aque -----------------QTYQNKLL-VP--EVL-AV------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque -------------------FP---H-DVT--FA-EV------------------------ AqueK495_Aque -----------------YGYP---C-IGQ--RF-LI------------------------ AqueK496_Aque -----------------NIYP---K-IIS--YI-SV------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque -----------------HGFP---T-IMY--NV-VV------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis NVVPVQPSINNSIDNNVENTNNNNNIINNNNNNNNNNNNNNNNNNSYNSNSNSNSNNNNN LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis NNSNNNNNNNINNNNINNNNNNNNNNNNNNNNNNNNNNSNNNSNNNSNSNSNSNSNNSNN LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis NNINNNNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNDNDNNNNDNNNNLNNSNLNNNNG LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap -----NAT-----------EESDALAKLRKTIINESL-NFKI------------------ LRRK1_Hsap -----SCK------------SLEGQEGLRQLIFHVTC-SMKDVG---------------- CG5483_Dmel -----SC------------RTLHNIHLLANIIYDTAM-QLRSP----------------- LRRK2_Mmus -----NAT-----------EESDALAKLRKTIINESL-NFKI------------------ LRRK1_Mmus -----SCK------------NLEGQEGLRQLIFHVTC-NMKDVG---------------- T27C10.5_Cele -----NS------------TSRNDVKALLNTIYRTAW-EVRM------------------ GbpC_Ddis -----SC------------TTGYDVDKLRQLIEDI------------------------- Pats1_Ddis -----SC------------TSGKGITSLREKLEAL------------------------- QkgA_Ddis -----SC------------VTGKGVKELKKRLIHE------------------------- QkgA_C2d_Ddis -----SC------------VTGKGVKELKKRLIHE------------------------- Roco10_Ddis -----STL------K----SDADGIRKLRRDIKQM------------------------- Roco11_Ddis -----SC------------TNGTGIKELKKILTNE------------------------- Roco4_Ddis -----CC------------ATGKGIKELKKRLIHE------------------------- Roco5_Ddis -----SC------------KSGKNINKLQNHIVKL------------------------- Roco6_Ddis -----SC------------STGVGFDNFLDLLKKT------------------------- Roco7_Ddis -----SL------------KNSKQIKQLVQRLQNN------------------------- Roco8_Ddis -----SS------------TTLRNIDLLKNEIIQTLL-NQSNNNNNNNNNNNYNNNK--- Roco9_Ddis SNINISSS------N----NILGGMPKLREEIKNVFL-NFK------------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur -----DAR------G----SKNSGMAELKRVIYETAM-QMKVHH-----------K---- LRRKb_Spur -----SAV-----------TDSGGINELRGMIENVIL-NEK------------------- LRRKa_Spur -----SCA------A---SSKSYNVNMLRDLVYDTAY----------------------- AqueK485_Aque -----SC------------TTGEGISQLRKTLYRIGAGSFRTT----------------- AqueK486_Aque -----GLM-----------NRLENIRTLREAIYNQAT-EYRG------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque -----GFGDPPFFGS---YLSPLRYEELSDKIHDIAC-SMEIPR-----------DS--- AqueK489_Aque -----STD------QESLIGRSNSIHSLIELIDR-------------------------- AqueK490_Aque -----SGS------P----SPRDNPVDVRMKIYEIAS-QM-------------------- AqueK491_Aque -----GCP------T---SGKAEGVSELRVALWDVAF-SLTAPR-----------KK--- AqueK492_Aque -----GLM-----------NRLENIELLREAIYNQAT-KYRG------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque -----SCV-----------GQKAGLDHLRNKIKEKID-SAK------------------- AqueK495_Aque -----NLS------V------GSEIEQLKAIIHQQAG-ELKVP----------------- AqueK496_Aque -----SCV------S----KFGNNMDKLRQLIYDVSV-HLKVSP-----------RDGIT AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque -----SCT------------SGSNINDLRDKIFDVAC-QVKENT-----------VTGRG LRRK2_Hsap ----------RDQLVVGQLIPDCYVELEKIILSERKN--V-------------------- LRRK1_Hsap -------STIGCQRLAGRLIPRSYLSLQEAVLAEQQRRSRD------------------- CG5483_Dmel ---------GSKEPMLLQKIPASYIALEDIVNVIACNLRA-------------------- LRRK2_Mmus ----------RDQPVVGQLIPDCYVELEKIILSERKA--V-------------------- LRRK1_Mmus -------STIGCQKLAGRLIPRSYISLQEAVLAEQQRRSLG------------------- T27C10.5_Cele ----------GKERAMEQQIPSSYIALMKVTKELGVEFRK-------------------- GbpC_Ddis ---------IKTQPYLKEKVPSSFFTLEEALIEVKKKR---------------------- Pats1_Ddis ---------VQSQSNMGESLPRSYMLLENLVKEETKKR---------------------- QkgA_Ddis ---------SEKSRLIKKDIPGSYIILEQRLSNRGANQGRMSISNSASN----------- QkgA_C2d_Ddis ---------SEKSRLIKKDIPGSYIILEQRLSNRGANQGRMSISNSASN----------- Roco10_Ddis ---------IAKNPILKQTYPASFMFLEDYLKEESNLM---------------------- Roco11_Ddis ---------AEKSNLIKSNIPGSYLILEQRLTDRGANSSRILINQNNINQNNNNNNNNNN Roco4_Ddis ---------AEKSHLIKKDIPGNYMVLEARLTNRGANPGRMAVS---------------- Roco5_Ddis ---------GKAEKKLGDLFSRSYFQLENLILSEREMN---------------------- Roco6_Ddis ---------VVELPSLKQSLPELYLKLEKLIIKKRSTL---------------------- Roco7_Ddis ----------AMMKQYHYKIPLSYSILKSQCQESVKEAYA-------------------- Roco8_Ddis -----QSNSISTTNWLNERIPSIYITLETNLQEEAK------------------------ Roco9_Ddis --------------PFGTKVSSSQKLFEKHI--KTL------------------------ LRRKd_Spur ------------------------FNLKKRISEEVEVRQKA------------------- LRRKc_Spur -------RPVCVEKLIGRKVPQPYFNLKKRISQEVEVRQKA------------------- LRRKb_Spur ---------IKGQPIFGQMIPYSYLRLEQLLQEQVRRLKS-------------------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ---------HPALLTIGIEIPTMYLQVEDLIRQLRGHLKT-------------------- AqueK486_Aque ---------NRSLPIMGQEIPASYFELNKELEKVQEEVRK-------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque -----DMPSSFSINLIDEKIPKCYLELEGAIQTLLEN----------------------- AqueK489_Aque ---------KGSFRRTTAIVPNSYSVLSEYTKSEATRLIE-------------------- AqueK490_Aque --------SANGSQVTGRQYPENYYHLLPVLEREHTNLKT-------------------- AqueK491_Aque -----GAIGGNKVKLLEQPVPSSYLRLEERMRELVVKCQSE------------------- AqueK492_Aque ---------KRSLPIMGQEIPASYIKLNEELEKVQEEVRK-------------------- AqueK493_Aque ------------------EIPASYIKLNEELEKIREEVRK-------------------- AqueK494_Aque ---------LRGQKIMGELVPASYLELSNILEEESRRLNKV------------------- AqueK495_Aque ---------NSSEKLIEEYVPRSYNGLQSHVESKIKLQ---------------------- AqueK496_Aque LVHDPKLSLSSSYALLNQQIPRNFLELQERVSDLVKDLNES------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque I---GCGRIPEYRLLMDQLVPASYLQLEDSVRSIALTLRLL------------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis --------------------------------SSSSLLNSSSSSSPSLTSKKSSSHLKHS QkgA_C2d_Ddis --------------------------------SSSSLLNSSSSSSPSLTSKKSSSHLKHS Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis HNNCNNNENCTTTAATAGTTTMTSTTTTTTNYSNENILNTSSNSLIALFT-------R-S Roco4_Ddis -------------------------------------------GSPI-GGG-SSAQ---- Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------P-I----E--FPVIDRKRLL-QLVRE----NQL--Q--LDENELPHAV LRRK1_Hsap --------------D----D--VQYLTDRQLE-QLVEQ----TPDNDI--KDYEDLQSAI CG5483_Dmel ------------A-G----R--DPVLDGEQYK-RLVTEQMRLHNYKSF--RDAAELQQAT LRRK2_Mmus ------------P-T----E--FPVINRKHLL-QLVNE----HQL--Q--LDENELPHAV LRRK1_Mmus --------------D----Q--VQYLTDRQLD-QLVEQ----TPGNDI--KDYEDLQSAI T27C10.5_Cele ------------E-G----Q--PAVMTVEAYR-ERVKKRMISKFGRPF--RDDIEFYAAC GbpC_Ddis -------------------I--PPVMMWQEYI-NLANI-------CNL--KDSVQIQRAT Pats1_Ddis -------------------I--IPTIPWTEFI-QMGTI-------CTI--TDEAELLRAT QkgA_Ddis QQQQQQHQQQQQQ-LQQS--IKEKYIDYDDYL-NECKL-------SY---LKPHEIKDAT QkgA_C2d_Ddis QQQQQQHQQQQQQ-LQQS--IKEKYIDYDDYL-NECKL-------SY---LKPHEIKDAT Roco10_Ddis -------------------S--PPLVTKKTLQ-QMART-------MEL--HNEPHFTQLK Roco11_Ddis NS----NSNLSNN-YQKP-LVNQKYIDYNDFE-RECKL-------SH---LAQEEIQGAT Roco4_Ddis ---------LSSN-AINS--QKERYIDYDDYM-NECKL-------SH---LQPEEIKGAT Roco5_Ddis -------------------T--PPIITLSEFT-EMAIS-------CGI---PQTSITAAA Roco6_Ddis -------------------V--PPVLTWQSFS-QMVLS------NLDF--HDEIHVKVAT Roco7_Ddis ------------R-N----K--MPLSSIPLIK-NIARI-------FS---IEPRDSEAAI Roco8_Ddis -------------------K--RPIVTWDEYQ-NIAKL-------SNFTTSSYEKLVRAT Roco9_Ddis -------------------Q--TPFISKKELF-SIGEM----------CKLDKIETKNTC LRRKd_Spur ------------DPP----I--LPIMTKTELADDIVKL----IPDSGL--RTPIELQEAI LRRKc_Spur ------------DPP----I--LPIMTETELA-QIVQL----IPDSGL--HTPEELQEAI LRRKb_Spur ------------E-G----Q--PPVMLHKQVI-KMIRE----NDL--Q--LDDNELSQAV LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------V-KTEGEL--KPFHSFNDIR-ERLRR----PLKQLD--ITASDFLTVL AqueK486_Aque ------------G-L----R--APVMNAAQFR-ELVHR----LNLPDI--CSDEELRTAT AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------N-P----H--KPLYKRDAFC-KLKEV----RDI--I--KDEDEVDAAM AqueK489_Aque ------------D-N----K--APIVSSWDMW-ELVRS----SPHHDL--AGHKELSLVT AqueK490_Aque ------------S-G----Q--PGIMEEGTLW-SLLSS----AIDQDM--PDSMELPVMI AqueK491_Aque ------------V-D----V--SPVMKESEFF-EAVQD--------II--PNPRELNQAV AqueK492_Aque ------------G-L----R--DPVMTVAQFR-NLVHK----LNLTDL--CSDEELRTAT AqueK493_Aque ------------G-V----R--DPVMNVAQFR-NLVHK----LNLTDL--CSDEELRTAT AqueK494_Aque ------------K-S----N--FRVIRRSQLD-ELMRR----SSLTQG--MDSIELEQAV AqueK495_Aque ----------------------VTLVRYGEFV-DSFRSFS-HQSGDLS--DGGKEFTLAC AqueK496_Aque --------------Q----K--PPYLSHEEFS-SRF-------LSIFE--GDEEEMNEAV AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque --------------G----K--PPVLTYKEFK-EYVFGDA-RTLVSRD--VGDRELEQAV LRRK2_Hsap HFLNESGVLLHFQD-----PA--LQLS----DLYFVEPKWLCKIMAQILTVKVEG-CP-- LRRK1_Hsap SFLIETGTLLHFPD-----TS--HGLR----NLYFLDPIWLSECLQRIFNIKGSR-SV-- CG5483_Dmel TWCHENGVLLHYDD-----A----TLR----DYYFLDPQWLCDMLAHVVTVREIN-P--- LRRK2_Mmus HFLNESGVLLHFQD-----PA--LQLS----DLYFVEPKWLCKVMAQILTVKVDG-CL-- LRRK1_Mmus SFLIETGTLLHFPD-----TS--HGLR----NLYFLDPIWLSECLQRIFNIKGSR-SV-- T27C10.5_Cele TFLHDCGELVRFED-----A----TLR----DLIFVDPLWLAEFLTSVVILRSP------ GbpC_Ddis EFLHNIGSIVYFND-----L-NSSTVG----KMVILDQQWIINCMSSLITSKLLI----- Pats1_Ddis MFLHQLGSLVYFPK--------EPGLK----QFVILDPQWITTMLSSIITTKHS------ QkgA_Ddis DFLHNLGIILHFDS---------PKLN----NLVVLDPQWLADVMSSLITFSHS------ QkgA_C2d_Ddis DFLHNLGIILHFDS---------PKLN----NLVVLDPQWLADVMSSLITFSHS------ Roco10_Ddis SLFNSLGSIALFEQFIRMEPGSTPQKT----EMIALNPIWIAKAIASLVCFNPQN-LPFN Roco11_Ddis EFLHNMGIILHYDT---------PILR----SLVVLDPQWLADVMSSLITFSHN------ Roco4_Ddis DFLHNLGIILHFDT---------PTLK----NLVVLDPQWLADVMSSLITFSHN------ Roco5_Ddis DFLKELGVIVYFDD-------PKSGLD----QFIFIDPPWLTRLMATIITSKPN------ Roco6_Ddis KALVPLGSISFFDE-----P----GLD----QYVFLDPQWLTGVFSSIITTKHK------ Roco7_Ddis KYLYEIGEVLYYRY-----EANDQLLN----ELVFLDSMWMSKLISAVLALKTQ------ Roco8_Ddis NTLNRWGSIIWFED-----S--KSSLK----DFVILDPQWFSDCFYKLLLAKHS------ Roco9_Ddis ELLTELGLLFWSED------------H----DWVILDPIWLSNTLNLLLTLKQS------ LRRKd_Spur LFLHEIGSIVHFTD-----HL--NGLN----DLYFIDPVWLACTLQRVTALPI---GS-- LRRKc_Spur NFLHEIGSIVHFTD-----HL--NGLN----DLYFIDPVWLACTLQRVTALPI---GS-- LRRKb_Spur RFLHETGVLLHYDD-----PS--QQLR----NVYFIEPQWLCKVMARVITVREIN-PLV- LRRKa_Spur ---SLTGILLHYED-----S----MLN----DYFFLDPQWLCDTLAKVVTIPEIN-PDV- AqueK485_Aque RFLHKRGVVFLHDS-----P----RVDDRNSPVVAINPQIIGFLLQRTIRSGEMH-G--- AqueK486_Aque LFLNDIRTILHYDD-----RS--HAIN----ELYFIDPQWLCKIMSQIVTVREKN-P--- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque HFLHNMGSVLHFPK-----P----NLE----EYYILSPQWWFDSCALVISPSNVN-ELIA AqueK489_Aque SFLQSISSILLLPA-----N--NSNER----DCYVLNRQWFVRAMSGLLRNHQ-N-LRI- AqueK490_Aque SFLKESGYLMHFDD-----P--NCRLN----QFHFLHPEWLVFTVHKLLHHLNYY----- AqueK491_Aque TFLHENGVLLHYAT-----P----ALN----HLYFIDPQWLCDMLAHVVTIPEVN-RFIQ AqueK492_Aque LFLNDIGTILHYDD-----RS--HGIN----ELYFIDLQWFYKVMCEIVTVREKN-S--- AqueK493_Aque LFLNDVGTILHYDD-----RS--HGIN----ELYFIDPQWLCNMMSEIVTVREKN-P--- AqueK494_Aque KFLHECGTLLHYDD-----IQ--SNLS----DLYFLDPQWLCSVMAKIITMKHLT--I-- AqueK495_Aque QFLHDSGTVYHYHA-----PN-TNPTA----DLFILNLQWLCNTLAKILYKAK-NG---- AqueK496_Aque NYLTLQGTLLHFDD-----Y----GLR----DLYFLDPQWLAKLMARLISPNSAKNMS-- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque RFLHDNGTLLHYDD-----P----LLK----ELYFVDPQWLSDMLAHIVTVREIN-PF-- LRRK2_Hsap --------------KH-P------------------------------------------ LRRK1_Hsap ---------------A-K------------------------------------------ CG5483_Dmel --------------FA-P------------------------------------------ LRRK2_Mmus --------------KH-P------------------------------------------ LRRK1_Mmus ---------------A-K------------------------------------------ T27C10.5_Cele --------------NL-P------------------------------------------ GbpC_Ddis --------------NN-C------------------------------------------ Pats1_Ddis --------------YA-K------------------------------------------ QkgA_Ddis --------------WI-K------------------------------------------ QkgA_C2d_Ddis --------------WI-K------------------------------------------ Roco10_Ddis VSVSAEEANDASHDST-I------------------------------------------ Roco11_Ddis --------------WI-K------------------------------------------ Roco4_Ddis --------------WI-K------------------------------------------ Roco5_Ddis --------------FV-Q------------------------------------------ Roco6_Ddis --------------FI-K------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis --------------FINS------------------------------------------ Roco9_Ddis --------------SSAPSTPPQIPLNSTNLNNTSIPSQITTTSTNSSSTSTSTSTSTST LRRKd_Spur ---------------L-K------------------------------------------ LRRKc_Spur ---------------L-K------------------------------------------ LRRKb_Spur ---------------S-K------------------------------------------ LRRKa_Spur -----------------K------------------------------------------ AqueK485_Aque ------------EGSI-L------------------------------------------ AqueK486_Aque --------------FI-K------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque -----------AGDEP-G------------------------------------------ AqueK489_Aque -----------------A------------------------------------------ AqueK490_Aque --------------HA-N------------------------------------------ AqueK491_Aque -----------RGSGP-E------------------------------------------ AqueK492_Aque --------------FI-K------------------------------------------ AqueK493_Aque --------------FV-K------------------------------------------ AqueK494_Aque ---------------I-S------------------------------------------ AqueK495_Aque -----------------S------------------------------------------ AqueK496_Aque ---------------L-V------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ---------------V-K------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis STSTSTSTSTSTPLQTPTSLVSLSNISLSTISIPIQPNTSSILLDSSMNDSFNKESSGSN LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ---------KGIISRRDVEKFLSK----KR----K---FP--KNYMSQYFKLLEKFQIAL LRRK1_Hsap ---------NGVIRAEDLRML-LV----GT----G---FT--QQTEEQYFQFLAKFEIAL CG5483_Dmel ---------TGVMKLDDLQML-FR----S---V-Q---V--Q------------------ LRRK2_Mmus ---------KGIISRRDVEKFLSK----KK----R---FP--KNYMMQYFKLLEKFQIAL LRRK1_Mmus ---------NGVIQAEDLRML-LV----GT----G---FT--QQTEEQYFQFLAKFEIAL T27C10.5_Cele ---------AGLLSTDAINPH-TR----SFK-S-G---A--LLMLKTQLLDLLHKFELAL GbpC_Ddis ---------NGIVRQSDLELV-WK----AP----T---YP--EHLHPALLSIMQAFEICR Pats1_Ddis ---------DGILNHKSLKQI-WR----PP----Q---YP--THLHPHLISLLEKFEISY QkgA_Ddis ---------LGILNHSDLQSI-WG----G-----R---YK--QTLWPSLLKLLEKFEVSY QkgA_C2d_Ddis ---------LGILNHSDLQSI-WG----G-----R---YK--QTLWPSLLKLLEKFEVSY Roco10_Ddis ---------TGILPHRVLRYV-WG----TNS-KYY---VP--ERFFSLFLSLLESNDLAI Roco11_Ddis ---------NGILNHSELVSI-WS----G-----K---YD--QSIWPSLLKLLEKFEVSY Roco4_Ddis ---------RGILNHSELVAV-WG----G-----K---YD--QSLWPLLLKLLEKFEVSY Roco5_Ddis ---------SGVLDQSNLHQI-WK----PP----D---FP--QHLHHVLLAILQKFEIVH Roco6_Ddis ---------DGVLKKSDLYQI-WK----PP----H---FIEDEGLHSLLINLLERFELMF Roco7_Ddis ---------NGMTVVDQITQA-WA----S-----L---FP--HCKTSSLLFLLEKFELVY Roco8_Ddis ---------DGILLLSNLKNI-WK----PN----I---VP--EQFHIKLLKLLERYQILY Roco9_Ddis KVANPTIRKRDIILMSNLEGI-WN----------D---IP--TRLYPYLLTLAKKFNIAY LRRKd_Spur ---------GGKVHVETLREL-SK----KS----S---IE--EDKFEQYLQLLARFEIVV LRRKc_Spur ---------GGKVHVETLREL-SK----KS----R---IG--EDKFEQYLQLLARFEIVV LRRKb_Spur ---------EGIMKVKDISLL-FN----DG----D---VP--KQLIPQYLKLLERFEVSL LRRKa_Spur ---------KGVMLVRDLHRK-FE----DS-------------SVKEFIVSLLNKFEVAV AqueK485_Aque ---------SGFLPNVHPAMI-WGVDPVLFADDNN---S--AGITGLQLIDFLTSVDLCA AqueK486_Aque ---------NGILHSRNVPFI-FC----DP----R---FQ--WKYFEQYLSLLDRFGIAL AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ---------SGLLRFQMMQVM-FS----EK----K---VS--SEQAKLIFSFLHQYGVLL AqueK489_Aque ---------NGLYPVRNLCDL-LH-----P----Y---FS--TDIPYAVYTVASLLSLAI AqueK490_Aque ---------HPIVTLHKLVSL-LK----L-----G---GE--KRLTTAVIRLLIRFHIVL AqueK491_Aque ---------AGILKTSVLSHI-FK----GK----L---FP--HTLRNEYIELLSKFEVAL AqueK492_Aque ---------NGIFYSRNVPFL-FR----DP----K---FQ--WEYFERYLTLLDRFEIAL AqueK493_Aque ---------NGIFYSRNVPFL-FR----DP----R---FQ--WEYFGCYLTLLDRFEIAL AqueK494_Aque ---------KGMLRKKDLPLI-LR----GS----Q---FP--PDFSSEYIRLMEWFDVAL AqueK495_Aque ---------APVLSMTVLQSL-LC----SI----G---LV--TNYHSALIGIMIKYNKLV AqueK496_Aque ---------DGKILLSSL----FE----QD----LFLSEH--RAIASKYLQLLQKFEVAL AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ---------DGIMKIKDFTLL-FN----DK----D---FP--IHWQKQYLRLLTTFEVAV LRRK2_Hsap P--IGEE----------------------------------------------------- LRRK1_Hsap P--VAND----------------------------------------------------- CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus P--IGEE----------------------------------------------------- LRRK1_Mmus P--VAND----------------------------------------------------- T27C10.5_Cele A--TQPR----------------------------------------------------- GbpC_Ddis S--LSPSD---------------------------------------------------- Pats1_Ddis N--LSPDS---------------------------------------------------- QkgA_Ddis Q--LPNL----------------------------------------------------- QkgA_C2d_Ddis Q--LPNL----------------------------------------------------- Roco10_Ddis N--IYSLEVNNNNNNNSNGNNVGRGRSGSRSMSIHEANRSNSYFGVNLNNTSSLSSFTSN Roco11_Ddis E--LPNEF---------------------------------------------------- Roco4_Ddis E--LPNI----------------------------------------------------- Roco5_Ddis P--LPDPK---------------------------------------------------- Roco6_Ddis P--LDSDL---------------------------------------------------- Roco7_Ddis I--SAED----------------------------------------------------- Roco8_Ddis T--LKNNS---------------------------------------------------- Roco9_Ddis Q--IDTLY---------------------------------------------------- LRRKd_Spur P--ISHH----------------------------------------------------- LRRKc_Spur P--ISHH----------------------------------------------------- LRRKb_Spur P--VSDD----------------------------------------------------- LRRKa_Spur T--YDPK----------------------------------------------------- AqueK485_Aque P--LVPG----------------------------------------------------- AqueK486_Aque P--LDNR----------------------------------------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque P--VDKE----------------------------------------------------- AqueK489_Aque P--VTSH----------------------------------------------------- AqueK490_Aque P--ISNS----------------------------------------------------- AqueK491_Aque L--LDRN----------------------------------------------------- AqueK492_Aque P--LNNR----------------------------------------------------- AqueK493_Aque P--LNNR----------------------------------------------------- AqueK494_Aque Q--YSNE----------------------------------------------------- AqueK495_Aque PLDIGRS----------------------------------------------------- AqueK496_Aque C--IGDK----------------------------------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque E--FKEG----------------------------------------------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis -----------------L------VRPEEVNEKE-------------------------- Pats1_Ddis -----------------T------S----------------------------------- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis QKVRNGRSSSFNARVGWA------LVSSLLAPPP--QLSIN------------------- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis -----------------A------TISSSSSSPSTTQKSLNN------S----------- Roco6_Ddis -----------------V------SLSSSNGNNGN---SYVNNNNNNNNNSNNNNNGSNK Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis -----------------N------LQQLQQQQQQ--QKSFGNLSKENSL----------- Roco9_Ddis -----------------DPTSWGFVYPSP------------------------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------GSN-LKSSGSAISTSSSSTTNGNKTLHRTNSTTNTT Roco6_Ddis SS-----PFKTTPSSPSTLRLVDSKSKGSHSSNPILS----------------------- Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis -NSMSYSIESRSSSSPL-PTVVTLSAE-ISSS-PSLSLSNS----SQSVF---------- Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis SLLNVSRFGNGSIS-------------------------------------------KGS Roco6_Ddis -------------GNNSSSKNSTSTK----------------------RSISGSP----- Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis -------TNPNNNNNNKSEQQQ---------QQQQQQQ--------QPQPISTSPKLLRN Roco9_Ddis ------------ISNQQQQQQQQ-SSTQHQHQHHHHQQQQQTSINLNRLSISGSPSLRSI LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis SL---------------------------------------------------------- Roco6_Ddis -------------------------------LRSRSNS---------------------- Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis SLKNLKSIENNSSSLSNNSILNSNSNSSGNLLQNGS------------------------ Roco9_Ddis SIRNGGNINTLNSSGSNNSSPLKFPNLALSPIRNGSNSNLTHHHGSNSSLNNLLSPLKNL LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ---------------------------------------------------YLLVPSSLS LRRK1_Hsap ---------------------------------------------------SYLLPHLLP CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ---------------------------------------------------YLLVPSSLS LRRK1_Mmus ---------------------------------------------------SYLLPHLLP T27C10.5_Cele ---------------------------------------------------QLLIPSLLP GbpC_Ddis -----------------------------------------------VMGDRNLVPNLLS Pats1_Ddis -----------------------------------------------FETGTSLIPSLLL QkgA_Ddis --------------------------------------------------SKSLIPSLLP QkgA_C2d_Ddis --------------------------------------------------SKSLIPSLLP Roco10_Ddis ---------------------GNCSISSNSS----SSSSSLSNA-LNLNNISSMIPII-- Roco11_Ddis -------------------------------------------------PSRSLIPSLLP Roco4_Ddis --------------------------------------------------AKSLIPSLLP Roco5_Ddis -------SIIKKINDQSTSPSNSTTPSPNTSSNNFSDSITL----VPKSSTKHLVPILLS Roco6_Ddis --------DLDLIGGGGGSPINGSSIDY------SSKSNTLTPGLFNELNQKFIIPSQLP Roco7_Ddis --------------------------------------------------SSVIIPQLFG Roco8_Ddis ----------------------------------------------YISFNRIIIPCLLP Roco9_Ddis QLQQKYDK-----------------------------------L-KLLNEKVIFLPNELP LRRKd_Spur ---------------------------------------------------WYLVPARLP LRRKc_Spur ---------------------------------------------------WFLVPARLP LRRKb_Spur ---------------------------------------------------KILLPCKVP LRRKa_Spur ---------------------------------------------------HLLIPSRLP AqueK485_Aque ---------------------------------------------------AVLIPSLLP AqueK486_Aque ---------------------------------------------------QILIPSMLP AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ---------------------------------------------------TALVPSMLS AqueK489_Aque ---------------------------------------------------NILIKSMLQ AqueK490_Aque ---------------------------------------------------AYLIPSLLP AqueK491_Aque ---------------------------------------------------RMLVPSMLP AqueK492_Aque ---------------------------------------------------QILIPSMLP AqueK493_Aque ---------------------------------------------------QILIPSMLP AqueK494_Aque ---------------------------------------------------LILIPSYLP AqueK495_Aque ---------------------------------------------------RFLFPSLLP AqueK496_Aque ---------------------------------------------------EVIIPSLFP AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ---------------------------------------------------KLLIPSHLP LRRK2_Hsap DHRPVIE----------------------------------------------------- LRRK1_Hsap SKPGLDT----------------------------------------------------- CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus DHRPVIE----------------------------------------------------- LRRK1_Mmus SKPGLDT----------------------------------------------------- T27C10.5_Cele DEYRLRS----------------------------------------------------- GbpC_Ddis DNTN-IV----------------------------------------------------- Pats1_Ddis NDRPAIF----------------------------------------------------- QkgA_Ddis DDPIGEI----------------------------------------------------- QkgA_C2d_Ddis DDPIGEI----------------------------------------------------- Roco10_Ddis -DLPGI------------------------------------------------------ Roco11_Ddis EEPIDRI----------------------------------------------------- Roco4_Ddis EDAEGEI----------------------------------------------------- Roco5_Ddis EERPNSI----------------------------------------------------- Roco6_Ddis EIRPSFG----------------------------------------------------- Roco7_Ddis GERPMVM----------------------------------------------------- Roco8_Ddis NGKPSHL----------------------------------------------------- Roco9_Ddis NEPPMSM----------------------------------------------------- LRRKd_Spur RDNPGVM----------------------------------------------------- LRRKc_Spur RDNPGVM----------------------------------------------------- LRRKb_Spur IQKPNIT----------------------------------------------------- LRRKa_Spur QEGVDTTIIPVFRSRSDSTRVYRKTGARSPSPIQSSPPERWNRKAVRGHSPSPSRIYCHD AqueK485_Aque RLPPAET----------------------------------------------------- AqueK486_Aque DKRPEKA----------------------------------------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque PIPTVKLFT--GQG-------------YFPRSV-----------------S--S------ AqueK489_Aque SANNDPI----------------------------------------------------- AqueK490_Aque HNPPPLA----------------------------------------------------- AqueK491_Aque SAPKQTL----------------------------------------------------- AqueK492_Aque DERPEKA----------------------------------------------------- AqueK493_Aque DERPENA----------------------------------------------------- AqueK494_Aque KEKPDSI----------------------------------------------------- AqueK495_Aque SLPPPHS----------------------------------------------------- AqueK496_Aque ESQSYPK----------------------------------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ELKPALS----------------------------------------------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur GSPTDGSSPR--ETSPETVETPERSPATMSIPVPIRRNLQGKARMANCASSPPCEMYSEA AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ----SSSSAYSEDIRSFFDDLPA------ALP---------------------------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur STSTMGLDAMDTPTFELLRKSATITKSPSSGDVNTGTVKGKLDRADIELVSNKAQDSKVP AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------L--P-------------------------------------------------- LRRK1_Hsap -----HG--M-------------------------------------------------- CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------L--P-------------------------------------------------- LRRK1_Mmus -----HS--M-------------------------------------------------- T27C10.5_Cele -----DF--LAS-----AVKIRMKMSQWNVRCPSPAGSPTKSPL-------RRTSPTDQN GbpC_Ddis -----AQ--W----------------------------------D--------------- Pats1_Ddis -----PS--LW---------------------------------G--------------- QkgA_Ddis -----LE--IK---------------------------------D------------R-- QkgA_C2d_Ddis -----LE--IK---------------------------------D------------R-- Roco10_Ddis ----------W---------------------------------E------------A-- Roco11_Ddis -----QE--IK---------------------------------E------------K-- Roco4_Ddis -----ST--IK---------------------------------D------------R-- Roco5_Ddis -----EK--LY---------------------------------D------------Q-- Roco6_Ddis -----LL--W----------------------------------P--------------- Roco7_Ddis -----RD--LW---------------------------------S--------------- Roco8_Ddis -----AS--LW---------------------------------D--------------- Roco9_Ddis -----DK--MF---------------------------------L--------------- LRRKd_Spur -----LS--PH---------------------------------N--------------- LRRKc_Spur -----LS--LH---------------------------------N--------------- LRRKb_Spur -----LP--I-------------------------------------------------- LRRKa_Spur SPFDGYK-FTP------------------------------------------------- AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque -----DI--P-------------------------------------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque --SLSRK--LQ------------------------------------------------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque -----MI--Q-------------------------------------------------- AqueK491_Aque -----YN--FKTLFPRPPIAYLL--QQSRIHSSSSLSDNRMSPYSSQSDPLMVRLPPK-- AqueK492_Aque -----DI--P-------------------------------------------------- AqueK493_Aque -----DI--P-------------------------------------------------- AqueK494_Aque -----T---L-------------------------------------------------- AqueK495_Aque -----SYD---------------------------------------------------- AqueK496_Aque -----PNDSLK---------------------------------D--------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque -----HC--YP---------------------------------P--------------- LRRK2_Hsap --------------HC-ENSEIIIRL-YEMP-YFPMGFWSRLINRLLEISPYMLSGRE-- LRRK1_Hsap --------------RH-PTANTIQRV-FKMS-FVPVGFWQRFIARMLISLAEMDLQL--- CG5483_Dmel -------------GNG-NRSQGLRRI-LLMT-YFPSGFWSRLITRILADEQIIEAIR--- LRRK2_Mmus --------------HC-ENSEIIIRL-YEMP-YFPMGFWSRLINRLLEISPFMLSGRE-- LRRK1_Mmus --------------RH-PMANTIQRV-FKMS-FVPVGFWQRFIARMLISLAEMDLQL--- T27C10.5_Cele GVGSEDVML---QFTY-DDDQLLRRI-YALA-YIPSGFWSRLVTRIVGDKNVCAAIE--- GbpC_Ddis ------------DFID-PDTILLNRQ-YHLP-FLPEKFFGKLIIHLMNFTKVESC----- Pats1_Ddis -------------SFN-QLVRQFGRI-YQFE-FVPNGFFSRLMVRILNFARVE------- QkgA_Ddis ----EWVPLKL-AMEN-NYVQVFGCD-YHFS-FMPLGFFARLLLRILLIQGID------- QkgA_C2d_Ddis ----EWVPLKL-AMEN-NYVQVFGCD-YHFS-FMPLGFFARLLLRILLIQGID------- Roco10_Ddis --------F----PES-PEIHQFSRR-FSLD-VIPNGLFGRLLSRLMQHAHL-------- Roco11_Ddis ----LWIPLPE-AIES-KRVQIFGCQ-YNFD-FMPLGFFPRLLLRILLIKGID------- Roco4_Ddis ----EWVTLPQ-AIES-GRCQVFGCD-YNFD-FMPLGFFARLLLRILLISGVE------- Roco5_Ddis ----I--LL----KSQ-QQQPFLERI-YQFE-FLPIGFFSKLMIRTMHFTTV-------- Roco6_Ddis ------------S-LD-HSRVEFNRW-IQLS-FAPAGLFSRLLIRLLISKEFDMK----- Roco7_Ddis -------P------TA-HANNEYLRI-YEFQ-FLPKGFFSRLSVRVLQHYDP-------- Roco8_Ddis ------------TWSG-EDEHQIGRY-YQFRNISAKNCFERVMVRFLYMME--------- Roco9_Ddis ------------D--V-GEPRSLCRI-FQFEKKIPSSFFPRLLSQLYMFCS--------- LRRKd_Spur -------------TDD-APFHYLRRI-YKMP-YLPPGFWIRLVSRLIADLQMRDKK---- LRRKc_Spur -------------TDD-APFYYLRRV-YKMP-YLPPGFWIRLVSRLLADLQMHDKK---- LRRKb_Spur --------------SD-ATQDLLLRY-YDMP-YIPLGLWSRMILRLLLFSKHM--MN--- LRRKa_Spur --------------VE-NLKTAIRRL-YILQ-YIPSGFWSHLISRLLSDQMIPGLIN--- AqueK485_Aque ------------VLNL-ED-LSPKRV-YILG-YLPSFFWCHLLSRVLRALAFHRFLQ--- AqueK486_Aque --------------DD-KSAPFYIRFINFQS-STPPGFWSRLISRIMHTVPQVCRALD-- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque --------------IK-TTGLVYRRL-FLLP-PLPTGFWSKLITLCLQKNDFVKIIV--- AqueK489_Aque ------------ASDL-SSQYQIQRL-YKFE-SLPMSLWPRLLSHLLINMNGMINRLT-- AqueK490_Aque -----------------VGCYRRQFI-PKGR-PLPEDFWFYLISHLLFHLPRLLKPDDST AqueK491_Aque ----SFSPMSPTTPDLYRTGLLLRRF-YFMK-YVPSGFWPRLISRFLTSSDFAVIVLK-- AqueK492_Aque --------------YD-KSAPLYIRFINFQS-SSPPGFWSRLISCIMHTVPQVCRALD-- AqueK493_Aque --------------YD-KSAPLYIRFINFQS-SSPPGFWSRLISRIMHTVPQVCRALD-- AqueK494_Aque --------------H--PSDNKIIRR-YKMI-FIPPGFWPRLIIRLLSFPKKA--IK--- AqueK495_Aque ---------------M-TKDEVVSRK-ILFR-YLPCCFFSHFVSRVLSYIDQAGAQLA-- AqueK496_Aque ------VTFTA-GVEL-NYLPPIRRI-WFSN-YIPDGFWPRLICRLLNDQLIKSILS--- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque -------------ENT-VYLPPLRHT-YLLA-FVPSGFWPRLMSRVLSDPSIMRLAQ--- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ----FEN--KKNTK---------------------------------------SRNRKVT CG5483_Dmel ---GV-----YMAS----------------------------------------QDYA-D LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ----FEN--KKNTK---------------------------------------SRNRKVT T27C10.5_Cele ---SI-----FMTT---------------------------------------SADRA-K GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ---------KKISS---------------------------------------AGNER-N LRRKc_Spur ---------KKISP---------------------------------------ARNER-K LRRKb_Spur ---GE----EDHAE-----------------------------------TIPI---WHMP LRRKa_Spur ---SM----YL-LS---------------------------------------------- AqueK485_Aque ---GD-----TLLT---------------------------------------PSSPS-S AqueK486_Aque ---VLADY-NNETE---------------------------------------STADEDT AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ---SV----DDCLQ---------------------------------------------- AqueK489_Aque ---------EDKM----------------------------G---------------E-- AqueK490_Aque LLNLLKVMQEDPVRNHQPRKPLNLHLDIGKEETSLMYSPTED---------------E-- AqueK491_Aque ---ALGFS-EKEI----------------------------E---------------E-- AqueK492_Aque ---VLADH-SNETD---------------------------------------STPDEDT AqueK493_Aque ---VLADY-NNETH---------------------------------------STADEDT AqueK494_Aque ---HA------------------------------------------------------- AqueK495_Aque ---VMAH--PSNPP---------------------------GPAEEKRKRSSSFRNTN-K AqueK496_Aque ---NY-----YDSV----------------------------------------EN---- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ----------VGCG---------------------------------------LTD---- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap IY----------------------S-FT---------------------------G---- CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus IY----------------------S-FT---------------------------G---- T27C10.5_Cele I----------------------------------------------------------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur LG----------------------S-SKR---LTDDE--------------MFPFQ---- LRRKc_Spur IC----------------------R-SK---------------------------S---- LRRKb_Spur VL----------------------N-TQ---------------------------G---- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque L----------------------------------------------------------- AqueK486_Aque IPGIPPAPNVTDETSAQMISSPVLS-PS---------------------------SNQFL AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque IPGVPPMPNVTDEMSAQMISSPVLS-PS---------------------------SNQFL AqueK493_Aque IPGVPPVTNVTNETSAQVISSPVLS-PS---------------------------SNQFL AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque -Y----------------------KLSRRSYIISEDSEDGGADASKAISISVTT-M---- AqueK496_Aque --------------------------S--------------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ---------NQ----------------R-------------------------------- CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ---------SQ----------------R-------------------------------- T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ---------RK----------------S-------------------------------- LRRKc_Spur ---------AK----------------S-------------------------------- LRRKb_Spur ---------SA---V--------S--TH-------------------------------- LRRKa_Spur ---------DD---V--------H--RFF----------------------E-------- AqueK485_Aque -----------------------------P------------------------------ AqueK486_Aque LPNINRFIVDDD------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ---------AS---L--------Q--GH-------------------------------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ---------------------------KIPGGEPSSHVPVKGRGTTAKKQRSFSDSGDTE AqueK491_Aque ---------------------------TV----------------------R-------- AqueK492_Aque LPNINCFIVDED---------------D-------------------------------- AqueK493_Aque LPNINCFIIDDD------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ---------DRQAQCGDAIRSRLDSVSK-------------------------------- AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ---------------------------------------RA------------------- LRRK1_Hsap ---------------------NR--CS---------T-FRV------------------- CG5483_Dmel ---------------------FD--LR---------T-SLE------------------- LRRK2_Mmus ---------------------------------------RA------------------- LRRK1_Mmus ---------------------NR--CS---------T-FRV------------------- T27C10.5_Cele ---------------------AD--IA-----------TKH------------------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ---------------------SI--SE---------A-ISF------------------- LRRKc_Spur ---------------------SI--SK---------G-IRF------------------- LRRKb_Spur ---------------------RQ--FR---------M-RSH------------------- LRRKa_Spur ---------------------GE--PL---------S-EFTNEFQWVCWQSGIELKFMSV AqueK485_Aque ---------------------PR-PAN---------PLVTP------------------- AqueK486_Aque ----------------------D--AK---------P-LKP------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ---------------------GA--LY---------N-IGT------------------- AqueK489_Aque ---------------------QL--LE---------S-FHN------------------- AqueK490_Aque LQVHATNDAGTIEDSTVSTVSKR--IS--------SDPIS-------------------- AqueK491_Aque ---------------------IM--IS--------GDLSTL------------------- AqueK492_Aque ---------------------ED--PK---------P-LKP------------------- AqueK493_Aque ----------------------N--TE---------P-FKP------------------- AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ---------------------SLPRREQFSTNEDSWT-TMY------------------- AqueK496_Aque ------------------------------------D-ESV------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque --------------------------------------EEC------------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur TVFHVKAVVREKLLSSVFERERRPESVHVLSLTDDPDHFPRNVSLSRSGQLEILIPNQTL AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur EVTHRIQQREANGKGMSDSVKILTSLETVSRLLATIIDLIDTLIENFYPNLCEPLGTTFE AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur GELFITRVVPCHRCWRDYNKPSWDEVDVSEWEFIHALDAEEHMNAEHESPLLWSSISSAD AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur AQMITTRTGEQSKLCCGLSCSYPRLHDDILTGVNLKQLNPRRRAAHALQRKDRIAATTNA AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur RLSADGDMTLQTEIDNDREHPLPLETCSELGIEPDVSNDMMPMDTVLNSTLLSSIHKSAD AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur VPHDICVYGFLFEELVLQSMRNEFVECPNHGNIAISVVAPDVVSVMLVRDLHRKFEDSSV AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur KEFIVSLLNKFEVAVTYDPKHLLIPSRLPQEGVDTTIIPVFRSRSDSTRVYRKTGARSPS AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur PIQSSPPERWNRKAVRGHSPSPSRIYCHDGSPTDGSSTRETSPETVETPERSPATMSIPV AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur PIRRNLQGKARMANCASSPPCEMYSEASTSAMGLDAMDTPTFELLRKSATITKSPSSGDV AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur NTGTVKGKLDRADIELVSNKAKDDKVPSPFDGYKFTPVENLKTAIRRLYILQYIPSGFWS AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ---------------------------------------LRPNRMYWRQGIYLNWS-P-E LRRK1_Hsap ---------------------------------------KRNQTIYWQEGLLVTFD-G-G CG5483_Dmel ---------------------------------------QDTQWNLWQTGLALYYG-P-I LRRK2_Mmus ---------------------------------------LRPNRMYWRQGIYLNWS-P-E LRRK1_Mmus ---------------------------------------RRNQTIYWQEGLLVTFD-G-G T27C10.5_Cele ---------------------------------------AKAEWVVWQTGIELHVK-G-H GbpC_Ddis ----------------------------------------------QKRAVILRNQ-DNH Pats1_Ddis ------------------------------------------AKCYWKNGMILQHD-EE- QkgA_Ddis ------------------------------------------IKTYWKDGVLLDIL-TP- QkgA_C2d_Ddis ------------------------------------------IKTYWKDGVLLDIL-TP- Roco10_Ddis -------------------------------------------YKCWKDLAILVPEIA-- Roco11_Ddis ------------------------------------------IKTYWANGILLDIL-TT- Roco4_Ddis ------------------------------------------VRTYWRNGVLLDIL-TP- Roco5_Ddis -------------------------------------------KEFWKNGLLVEKD-D-- Roco6_Ddis ------------------------------------------PILYWRNGVVVESQ-SG- Roco7_Ddis -------------------------------------------LCIWQNGMVLQPA-GQ- Roco8_Ddis ------------------------------------------PIVYWSTGILFRKT-QT- Roco9_Ddis ------------------------------------------IKHCWKNGVILENC-YL- LRRKd_Spur ---------------------------------------HQTESIYWREGIFFRHN-T-G LRRKc_Spur ---------------------------------------LQTESIYWREGIFFRHK-T-G LRRKb_Spur ---------------------------------------EEPETVFWREGIYVCWS-E-E LRRKa_Spur HLISRLLSDQMIPGLINSMYLLSDDVHRFFQGEPLSEFTNEFQWVCWQSGIELKFM-S-V AqueK485_Aque ---------------------------------------TGARLFLWQKHFVFEDI-D-G AqueK486_Aque ---------------------------------------EDIELLYWKNGIVYKGP-D-L AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ---------------------------------------TNVRWRYWKTGLVFDVD-H-Q AqueK489_Aque ---------------------------------------NAVNWNYWASGIIVWIN-A-T AqueK490_Aque ---------------------------------------ICQGIIVWRTGIQLKTG-SGV AqueK491_Aque ---------------------------------------VELEWSYWTTGVEFWYK-G-Y AqueK492_Aque ---------------------------------------KDIELLYWKSGIVYKGP-D-L AqueK493_Aque ---------------------------------------KDIELLYWKSGIVYKDP-D-L AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ---------------------------------------MFSRALIWKDGFHLEFL-D-G AqueK496_Aque ---------------------------------------VKSDWTCWKSGLVYVSR-G-R AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ---------------------------------------RLLKWTKWRTGMILRFG-N-V LRRK2_Hsap -A-YC---------------L--------------------------------------- LRRK1_Hsap -Y-LSVES----------SDVN-------------------------------------- CG5483_Dmel -L-IFKIW-----------EVP-FQK---------------------------------- LRRK2_Mmus -A-YC---------------L--------------------------------------- LRRK1_Mmus -Y-LSVES----------SDVN-------------------------------------- T27C10.5_Cele -S-LFTLK-----------QFLPLAE---------------------------------- GbpC_Ddis -E-ALIEL----------K----------------------------------------- Pats1_Ddis -T-IFL------------------------------------------------------ QkgA_Ddis -SDK----IKQQQLLQKKSIFE-------------------------------------- QkgA_C2d_Ddis -SDK----IKQQQLLQKKSIFE-------------------------------------- Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis -EDIKIQ-----KLNHKKHSIL-------------------------------------- Roco4_Ddis -EQVKLQQSKQQQLQQQQQ-QQ-------------------------------------- Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis -K-SFLST----------S----------------------------------------- Roco7_Ddis -L-WGGAA----------K----------------------------------------- Roco8_Ddis -Y-RENIK----------D----------------------------------------- Roco9_Ddis -S-FPVARRFP-MSPNAKN----------------------------------------- LRRKd_Spur -Q-ILVRS----------M-VF-------------------------------------- LRRKc_Spur -Q-ILVRS----------T-VF-------------------------------------- LRRKb_Spur -A-FFLIE-----------PLK-KG----------------------------------- LRRKa_Spur -T-VFHVK-----------AVV-REK---------------------------------- AqueK485_Aque SK-LWLVV-----------Y---------------------------------------- AqueK486_Aque -S-FGV-E-----------SF--------------------------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque -L-LLSIN-----------SLK-MDE---------------------------------- AqueK489_Aque -S-LVYSI----------ESIN-------------------------------------- AqueK490_Aque -Q-LTIHS----------Q----------------------------------------- AqueK491_Aque -S-LLR-V----------AEIR-------------------------------------- AqueK492_Aque -S-FGV-E-----------SL--------------------------------------- AqueK493_Aque -S-FGV-E-----------SL--------------------------------------- AqueK494_Aque ---YFMIE-----------QLE-SS----------------------------------- AqueK495_Aque -T-LCWAE-----------F---------------------------------------- AqueK496_Aque -T-LLLVR-----------HIP-NPP---------------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque -T-LLSM-----------EELS-GKLFTGNGTKMAIMKDGGRWEEHPLDTTVYGVNVEVP LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ---------------------------------------------T-ERTQ--------- LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ---------------------------------------------V-RDID--------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------PTTTLSPFLCSLSLTDSQ QkgA_C2d_Ddis ------------------------------------------PTTTLSPFLCSLSLTDSQ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------P----------------- Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ---------------------------------------------LL------------- AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ---------------------------------------------FI------------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------PEGTFSDCLP-------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque --------------------------------------------TSW------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque DVFPLLRYAELNPNRIRIVQRSGSTGQQEEEGEEQEEERVRRPRQHLGD----------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ----------------------------------------------PFR--TDGNRFKLK LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele -----------------------------------------------YS----AIDMRAK GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis NYSPLEPPPLILNSPRVNRKFISNSTSTTSTTTSTTS----------------------- QkgA_C2d_Ddis NYSPLEPPPLILNSPRVNRKFISNSTSTTSTTTSTTS----------------------- Roco10_Ddis ---------------------------SMSTTSSSSS----------------------- Roco11_Ddis ----------------------NNSSSTSSSTSSSTS----------------------- Roco4_Ddis ---------------------NNNESNDSSVNNNNNN----------------------- Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur -------------------------------------SSVFERERRPESVHV-------- AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque -------------------------------------DPM------QRA--V-------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ---------------------------------SSAQ----------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque -------------------------------------GPT------PES--S------LK AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ---------------------ITEDPRERSFSDSMRTPPTQ-----PPA--A------SG LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel Q-DGIWSDVN-------------------------------------------------- LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele DEQKRWRTWN--------------Q----------------------------------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------TSTTSSNNITPLSMSSITPYSPTSPRTPSF QkgA_C2d_Ddis ------------------------------TSTTSSNNITPLSMSSITPYSPTSPRTPSF Roco10_Ddis ------------------------------------------------------SSTANS Roco11_Ddis ------------------------------SSTSSSSS----------------SSTS-S Roco4_Ddis ------------------------------NNNNNNNNI--------------------- Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ---------LSL--T-------DD--PD-------------------------------- AqueK485_Aque ---------E-------------------------------------------------- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ---------ISATYDKMKRFHFADSNGD-------------------------------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------G-----------------SSYSRTPSIPF- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque AVNSKWRIEI-------------------------------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque SRNKRWTISE--------------KVGSIARKVRSYTNIAD------------------I LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ---------------------SSSSTTTSSSS----SSSSPSS-QFCGVGCHR------- QkgA_C2d_Ddis ---------------------SSSSTTTSSSS----SSSSPSS-QFCGVGCHR------- Roco10_Ddis ---------------------TTTTSATTLQS-----LASGS------------------ Roco11_Ddis ---------------------SSTSTTTTTVQIQSSPFGNSTTIVNKLTNIDN------- Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ----HFPRNVS---LSRSGQL-----------------------EILIP----------- AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ----VLP---V---LGSTEVI-----------------------EVVVK----------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque --------------------------------------------HIYVP----------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque NDSLTLP---PTSSVSQSPRVA--------------------SGFVVLPDHHSNSSSSDS LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ----------------------NIN--KNNGSSNELIKTLTKINNQNGSSGELIKTTTTT QkgA_C2d_Ddis ----------------------NIN--KNNGSSNELIKTLTKINNQNGSSGELIKTTTTT Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ----------------------NNNNNNNNNNNNN---NNNNINNNNNNNNNNNNNNNNN Roco4_Ddis -----------------------------------------------------INSSSSS Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque EDEKKDKEEEEGESTGGIGRVRGVL--R-------------------------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis STST-STTSTTTPTTTT-PTIPIKNNNN---------------------------KKLP- QkgA_C2d_Ddis STST-STTSTTTPTTTT-PTIPIKNNNN---------------------------KKLP- Roco10_Ddis ------------------------SNN-------------------------T------- Roco11_Ddis N-----------NNNNNNNNNNNNNNNNIKNIINNFENQNNLNNIITNNFGGKFE--IIK Roco4_Ddis SLNLTQTSTSTSPSKLSLNNSQ-INNSN-----------------------STLNSQQL- Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque --------------------EPLEDCED---------------------------LSFQ- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap -----------------------VGSEVL-------------------------DN--H- LRRK1_Hsap ------------------------------------------------------WK-KK- CG5483_Dmel ---------LSSSSILEVYF-P-LYEVNI--------------S----------QEV--- LRRK2_Mmus -----------------------VGSEVL-------------------------DN--R- LRRK1_Mmus ------------------------------------------------------WK-KK- T27C10.5_Cele ---------PSHRPIVEMV----VNSLSI--------------S----------AA---- GbpC_Ddis ---------------------T--IK----------------------------DNKDGT Pats1_Ddis -------------------------------------------------------EMNN- QkgA_Ddis INRTVSSLCLTAKPKLQALI-TFIKKKSF--------------E----------QSHDN- QkgA_C2d_Ddis INRTVSSLCLTAKPKLQALI-TFIKKKSF--------------E----------QSHDN- Roco10_Ddis -----------------LQQ-QFREERIL-------------------------VNVDH- Roco11_Ddis KNDFESPLS-SKKPKHQVLV-TFKNQKSF--------------E-----------SKDK- Roco4_Ddis INPSVSPLS-STTPRHQALI-TFIKKKSF--------------E-----------SKDK- Roco5_Ddis -------------------------SQCL-------------------------IESIQ- Roco6_Ddis ---------------------TA-LIEMV-------------------------PSYAN- Roco7_Ddis ---------------------SF-DSQCL-------------------------IEYDS- Roco8_Ddis ---------------------SMSSCGTL-------------------------VEFDT- Roco9_Ddis ---------------------PFRRSST--------------------------ISVLE- LRRKd_Spur ------------------------------------------------------PS-TD- LRRKc_Spur ------------------------------------------------------PS-TD- LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ---------------------------------------NQTLEVTHRIQQREANG-KG- AqueK485_Aque --------------GGQLG----PEST----------------------------Q---- AqueK486_Aque -----------------------RKSKVL-------------------------AR--I- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ---------------------S--SD----------------------------LGL--- AqueK491_Aque LNGQWLA-------------------------------------------------VDET AqueK492_Aque -----------------------RKSKVL-------------------------AG--T- AqueK493_Aque -----------------------RKSKVL-------------------------AH--T- AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque --------------EMISVLQEIRSRV-E-------------------------CF-DQ- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------KEEIQTQFEELKKKRAHGHHPGAIWNND-------------FNT-MS- LRRK2_Hsap PESFLKIT--V---PS------------------------------------CRKGCILL LRRK1_Hsap KSGGMKIV--C---QS------------------------------------EVRDFSAM CG5483_Dmel DDNERQLLAEI---RPH-----------------------------------MSQVAKLL LRRK2_Mmus PESFLKIT--V---PS------------------------------------CRKGCILL LRRK1_Mmus KSGGIKII--C---QS------------------------------------EMRDFSAM T27C10.5_Cele SQHGRKLS--M---KTD-----------------------------------VEGRSRLL GbpC_Ddis FKKILTVD--V---RG------------------------------------LVSPVSLL Pats1_Ddis AKKSLSFT--V---RG------------------------------------GANSTTLS QkgA_Ddis DSYKLNIQ--V---RTYNT---------------------------TI--DKEHSVSLFF QkgA_C2d_Ddis DSYKLNIQ--V---RTYNT---------------------------TI--DKEHSVSLFF Roco10_Ddis DSNTIEIT--I---R-------------------------------------FIRPSTLS Roco11_Ddis DTYKLNVE--I---RSFNV---------------------------SNNNDKDFLASLFF Roco4_Ddis DSYKLNIE--V---RSFNT---------------------------TI--EKDHSASLFF Roco5_Ddis QFNQINFK--A---W-------------------------------------GKNPASLL Roco6_Ddis CSSTIKIS--V---RGD-------------------------------RRTGRGLSAKLL Roco7_Ddis VNFILKVS--I---RD------------------------------------DNKQQQLL Roco8_Ddis VTQQLQIR--V---RGH--------------------------------E--FDACAKLF Roco9_Ddis ADDLVSIQ--V---LGD--------------------------------TKIEISSSKMC LRRKd_Spur KSPGVDIL--I---SC------------------------------------QEGHFSAM LRRKc_Spur KSPGVDIL--I---SC------------------------------------QEGHFSAM LRRKb_Spur -ADTLKIT--V---PK------------------------------------TKQGYRLL LRRKa_Spur MSDSVKIL------TS------------------------------------LETVSRLL AqueK485_Aque YCGRIDVLLK----TAT-----------------------------------REKEAVLL AqueK486_Aque NGDSIVIL--A---SP------------------------------------NSKGTKLI AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ---DIELS--CNAGYD------------------------------------RAVGPKLL AqueK489_Aque -NFSLIIS--V---------------------------------------ANTPLGIRAM AqueK490_Aque EETGVEVC--C---TE------------------------------------DEEGIAAM AqueK491_Aque PNTGLEVL--V---PDYICPSVIEKVLPSLVNIDEGAEDEFDQEPFP-TREHSWMSAQLL AqueK492_Aque NRDGIVIL--A---SP------------------------------------NSKGTKLI AqueK493_Aque NRDGIVIL--A---SP------------------------------------NSKGRKLI AqueK494_Aque -KNEFDIT--V---PN------------------------------------TTLGIRLL AqueK495_Aque FNESVSII--C---KGD-----------------------------------EKAKVKLL AqueK496_Aque LEETDKLQ--A---PYK----------------------------------VAGQATQLM AqueK497_Aque ---------------S------------------------------------NNDDFSAI AqueK498_Aque SNGPPKLT--E---ENN-----------------------------------DRMRAGLL LRRK2_Hsap GQVVDHIDSLMEEWFPGLLEIDICG-E-GETLLKKWALY-----------------S--- LRRK1_Hsap AFITDHVNSLIDQWFPALTATES---D-GTPLMEQYVPC-----------------PVC- CG5483_Dmel ALTVDHIDLLLEDWYPSLGTRFVHTSE-GRFLITRLVLC-----------------PRC- LRRK2_Mmus GRVVDHIDSLMEEWFPGLLEIDICG-E-GETLLKKWALY-----------------S--- LRRK1_Mmus AFITDHVNSLIDQWFPALTATES---D-GTPLMEQYVPC-----------------PVC- T27C10.5_Cele AMISDLLDTLLEDWYPALGTRFVHSSE-GDLLVSRYVLC-----------------PQC- GbpC_Ddis RIVTDTIESLFSQWYK-L-------------DIKRYISC-----------------YEC- Pats1_Ddis RDVIETIQSLLDDSFQ-L-------------PTYVFVPC-----------------FHC- QkgA_Ddis QQLLFTIDTLISGSYQGL-------------EVTRTIPC-----------------THC- QkgA_C2d_Ddis QQLLFTIDTLISGSYQGL-------------EVTRTIPC-----------------THC- Roco10_Ddis SQVYSIFESLVSKWYK-V-------------SFKTFIPC-----------------SHC- Roco11_Ddis QQLLSTIDTLLSGSYGGL-------------KVTRLIPC-----------------IHC- Roco4_Ddis QQILFTIDTLLASSYVGL-------------EITRMIPC-----------------IHC- Roco5_Ddis RFIIETAEVLISGWYK-L-------------HFHFLVPC-----------------N-C- Roco6_Ddis RLIVEIADTLCTSWYH-L-------------ETNQVIPC-----------------PHC- Roco7_Ddis KSIVDLVSSFILWYFPGR-------------LSNVRVAC-----------------THC- Roco8_Ddis QIVLENVDTILKDYQ-IN-------------QSQTYIPC-----------------SC-- Roco9_Ddis RHILQIFESILESYN-QL-------------AYTIYISC-----------------IHC- LRRKd_Spur GCVVDQIEGLIKDWYPGLCTSIHE--S-IQPKVQRLVPC-----------------PIC- LRRKc_Spur GCVVDQIEGLIKDWYPGLCASIYD--S-LQPKVQRLVPC-----------------PIC- LRRKb_Spur GLVSDHLDDLIEEWFPGLCELDPR--L-GRPLVQRLVPC-----------------VMC- LRRKa_Spur ATIIDLIDTLIENFYPNLCEPLGTTFE-GELFITRVVPC-----------------HRC- AqueK485_Aque RIVTEEIDQLLMEKYPSLLDDYLTPS-----LVDVLVPL-----------------SSS- AqueK486_Aque CQLVDIILSLIHEWYPGLEENNVNS---G---VEQRVPC-----------------YEC- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque SKALEMIDEVLKGHYEKLAENGIY-TV-G--EMLHIVPC-----------------PLC- AqueK489_Aque NLLSFTINTLIMNWYPQLWDTVSIN-----------GIC-----------------SVC- AqueK490_Aque AKVCWLIQRIFEQRYPEFSPKIQPS---SQNGLTQIILC-----------------PQC- AqueK491_Aque SQTVEQIDTLLEDWFPGIGSKDGGRGMYSVPYVNRVVPC-----------------PYC- AqueK492_Aque CQLVDIILNLIYEWYPGLEENSVNS---G---VEQRVPC-----------------YEC- AqueK493_Aque CQLVDIILNLIHEWYPGLEENNVNS---G---VEQKVPC-----------------YEC- AqueK494_Aque CSVVDNVETLIDEWFPGLRSISIT--S-GDALVSPSALC-----------------PLC- AqueK495_Aque AFLLSCVQDICTEWYINLHR-------------VHYSPC-----------------YSC- AqueK496_Aque VAISNHI-SFLSSWFQGMLEQNE---R----GHVDYVPC-----------------WKC- AqueK497_Aque GYVVDQLDSLIDEWFPGLNDLDL---D-GEWLVERQALWITPPELKESISAEPGTESECF AqueK498_Aque SKVVDHITLLVEDWFTGVRPR------------FLVVPC-----------------PHC- LRRK2_Hsap ----F------------------------------------------------------- LRRK1_Hsap --E-T------------------------------------------------------- CG5483_Dmel --L-W------------------------------------------------------- LRRK2_Mmus ----F------------------------------------------------------- LRRK1_Mmus --E-A------------------------------------------------------- T27C10.5_Cele --V-R------------------------------------------------------- GbpC_Ddis --A-I------------------------------------------------------- Pats1_Ddis --I-F------------------------------------------------------- QkgA_Ddis --I-Q------------------------------------------------------- QkgA_C2d_Ddis --I-Q------------------------------------------------------- Roco10_Ddis --I-E------------------------------------------------------- Roco11_Ddis --I-E------------------------------------------------------- Roco4_Ddis --V-Q------------------------------------------------------- Roco5_Ddis --I-NCNSILISNIGSINIINSTINLSSNNNNNVNIVNSQQQQQQQQQQSPSTSTSSSSS Roco6_Ddis --I-N------------------------------------------------------- Roco7_Ddis --T-N------------------------------------------------------- Roco8_Ddis --S-C------------------------------------------------------- Roco9_Ddis --I-E------------------------------------------------------- LRRKd_Spur --V-I------------------------------------------------------- LRRKc_Spur --V-I------------------------------------------------------- LRRKb_Spur --E-G------------------------------------------------------- LRRKa_Spur --W-R------------------------------------------------------- AqueK485_Aque --W-F------------------------------------------------------- AqueK486_Aque --R-K------------------------------------------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque --F-G------------------------------------------------------- AqueK489_Aque --Y-S------------------------------------------------------- AqueK490_Aque --S-K------------------------------------------------------- AqueK491_Aque --V-G------------------------------------------------------- AqueK492_Aque --R-K------------------------------------------------------- AqueK493_Aque --H-K------------------------------------------------------- AqueK494_Aque --P-A------------------------------------------------------- AqueK495_Aque --L-K------------------------------------------------------- AqueK496_Aque --Y-G------------------------------------------------------- AqueK497_Aque YDPLN------------------------------------------------------- AqueK498_Aque --S-H------------------------------------------------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis LTSSQPSLSTPLTSSQPSLSTSQPQLSTTTTTTATTTTSSSSQSLASQQSSSQIQLTHSS Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis SLSSMSGSISTNSLNSNVSSSSSTPSLLSPPLLNPDSTSSSNETSGDILDLDFADYYDGE Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis SVSPGGTLKGKRKKNPSKFLTLYRNTNKPKINGTTGSGSSSSIVTTAVSSSSSSSSSTSL Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap --------------------------ND-G------------------------------ LRRK1_Hsap --------------------------AWAQHT---DPSE--------------------- CG5483_Dmel --------------------------KLQLQQN-NEPSDREVPPVGCNRPSRSSRRGAGA LRRK2_Mmus --------------------------ND-G------------------------------ LRRK1_Mmus --------------------------SWAQHA---DPNE--------------------- T27C10.5_Cele --------------------------DAERNG---SRSRTS-SSASHR------------ GbpC_Ddis --------------------------LY-D------------------------------ Pats1_Ddis --------------------------LS-L------------------------------ QkgA_Ddis --------------------------LNPT------------------------------ QkgA_C2d_Ddis --------------------------LNPT------------------------------ Roco10_Ddis --------------------------KK-I------------------------------ Roco11_Ddis --------------------------KDPH------------------------------ Roco4_Ddis --------------------------KNPR------------------------------ Roco5_Ddis SNTSSRQLDLSKISHLINQQLSFGPSKT-Q------------------------------ Roco6_Ddis --------------------------KP-------------------------------- Roco7_Ddis --------------------------QH-I------------------------------ Roco8_Ddis --------------------------EC-R------------------------------ Roco9_Ddis --------------------------TLPK------------------------------ LRRKd_Spur --------------------------HGPDDF---EPVT--------------------- LRRKc_Spur --------------------------HGPDDL---EPVT--------------------- LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur --------------------------DYNK------PSW-D-E----------------- AqueK485_Aque --------------------------TTDLLSPSSSPDS-----------------LHEA AqueK486_Aque --------------------------LG-R------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque --------------------------EIDT-R---SPKS-D-H----------------- AqueK489_Aque --------------------------NDE------------------------------- AqueK490_Aque --------------------------S-PL------------------------------ AqueK491_Aque --------------------------GAEV-----TP----------------------- AqueK492_Aque --------------------------LG-R------------------------------ AqueK493_Aque --------------------------LG-C------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque --------------------------NDP--------EK-A-P----------------- AqueK496_Aque --------------------------GLEWIG---NPPS-D-T----------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque --------------------------GLTGPT---QGSDRI-PFL-------------RS LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel YFLHGVGDPGE--------------DGAL-------NVFSA-YLN----A---------- LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ---R----SQD--------------DGEL-------PI---------------------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------VD-VSEWEFIHALDAEEHMNAEHESPLLWSSISSADAQ---------- AqueK485_Aque FSIGGRGGRDEDEEGVAIPNLSYSLKGRG-------HSFSS-IVD----STSLQSFSSIQ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------KR----FA-------------N-------------------------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ----------ND---------------------------VFTS-MSHGPE---------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------LLI--------------------------------------------- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque FSINPQVRPPNDLVDSS-F-------------YPYSAPTQAH-IA--------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel -TARRE---RRSEDSLGAGSDADSG----------------V---GPDS----------A LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------T----------S GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur -MITTR---TGERSKLCCGLSC--SYPRLHDDILTGVNLKQLNPRRRAAHALQRKDRIAA AqueK485_Aque GTLHEAFASIRATGTLPSSVSSE-E----------------VPNFDPGS----------I AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque -------------------------HPKL-------------------------AQRIRT AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ----TL---TGTPSVISMNTKE--DAATPSSTVTLLDNTNSIDTNSVSTTGGVASRARRD AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque -----------------------------------------------------------S LRRK2_Hsap -------------------------------------------E---------------- LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel GSSRNTSV--DGH----------------------------------------------- LRRK2_Mmus -------------------------------------------E---------------- LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele SSHM-KGS---RT----------------------------------------------- GbpC_Ddis -------------------------------------------R---------------- Pats1_Ddis -------------------------------------------P---------------- QkgA_Ddis -------------------------------------------I---------------- QkgA_C2d_Ddis -------------------------------------------I---------------- Roco10_Ddis -------------------------------------------V---------------- Roco11_Ddis -------------------------------------------S---------------- Roco4_Ddis -------------------------------------------A---------------- Roco5_Ddis -------------------------------------------D---------------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis -------------------------------------------E---------------- Roco8_Ddis -------------------------------------------D---------------- Roco9_Ddis -------------------------------------------S---------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur TTNARLSAD-------GDMTLQTEIDNDREHPLPLETCSELGIEPDVSNDMMPMDTVLNS AqueK485_Aque RSNPQSSL--GGR----------------------------------------------- AqueK486_Aque -------------------------------------------E---------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque SSVSRSSTG-------RQ------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque -------------------------------------------G---------------- AqueK491_Aque LMPSLQKTTASGSPHSRRRYTSDNIDDTSIETSPAATGVGLMQA---------------- AqueK492_Aque -------------------------------------------E---------------- AqueK493_Aque -------------------------------------------E---------------- AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque TIASQSSVPQQRSRWGW--------------------------GRGQG--ASP------- LRRK2_Hsap ----------------EHQKILLDDLMKKAEEG-DLL-VNPDQ-----------PRLTIP LRRK1_Hsap ------------K-SEDVQYFDMEDCVLTAIE-RDF-ISCPRHPD-----------LPVP CG5483_Dmel ---PGYH--LPDN-SNVCYAWMIEECILSVYN-QSK-ISCPVHL-------------EQS LRRK2_Mmus ----------------EHQKILLDELMKKAEEG-DLL-INPDQ-----------PRLTIP LRRK1_Mmus ------------R-SESVQYFDMEDCVLTAIE-RDF-ISCPRHPD-----------LPVP T27C10.5_Cele ---TGDI--SKCR-GGVVHCFVIEECMLAGRE-YNW-VECPSHG-------------GLH GbpC_Ddis ----------------NPTLFTIEECELAVIDGKTVL-TCNQKSDSDR----VSTSHRLK Pats1_Ddis ----------------QCYYFPLDVCENAAVKGTGYL-KCLTY-D-----------ANVR QkgA_Ddis ----------------EPYHFDLGDCISALEDGRSHV-YCGNDPN-----------TPVR QkgA_C2d_Ddis ----------------EPYHFDLGDCISALEDGRSHV-YCGNDPN-----------TPVR Roco10_Ddis ----------------TPHLFKLEECEAQIFKGELGI-YCQYKPNNNNS--SNDTSSPIA Roco11_Ddis ----------------EPHLFDINSCISQLLLGKSQL-VCGKDST-----------TPVR Roco4_Ddis ----------------DPYYFDFSSCISALQDGKPHL-FCRNDPS-----------IPVR Roco5_Ddis ----------------LRTMFLYEEIERIFLSKKFEV-VCRSSIT--------GEETIVR Roco6_Ddis ----------------NCTLFSLSDCEAVASSGVWYL-LCGD--------------RKIN Roco7_Ddis ----------------NPTMYTLDYLENQASLGQTNV-ICKAQLGGIIHETLSPRTTKID Roco8_Ddis ----------------LPHLFPIDLIEETFGKGESHT-KCPITMK------------LVS Roco9_Ddis ----------------EQYLFSLNQIEESVIKGKTYQ-SCPIHSS-----------IPIK LRRKd_Spur --------------EDLPHCYTVEELAQTYVRGETHITACANSKE-----------KPIT LRRKc_Spur --------------ENLPHCYTVEELAQKLARGETHITACANSKE-----------KLIP LRRKb_Spur ----------------RPHLHDLSELLEQSET-SDT-ITCPNHPT-----------RKVP LRRKa_Spur TLLSSIHKSADVPHDICVYGFLFEELVLQSMR-NEF-VECPNHG-------------NIA AqueK485_Aque ---Q-VI--DETQ-TQIQYLVPAWECLQESFK-SPA--QQLRSG-------------KLD AqueK486_Aque ----------------KPFEFKIDQYMSIITSSRPQI-ECGYERDA-------ARNHKVS AqueK487_Aque --------------------------------------EYVEH-------------GSIP AqueK488_Aque ---KSIH--QRLG-EDVLIVFSIDQCIRSSMN-VEY-IECPKHG-------------DIQ AqueK489_Aque ----------------SLSLFPINDCFNSLTN-ARTL-SCPKDHE-------------LS AqueK490_Aque ----------------GATNFIIETCFVSLKEQESFTHNCHHH-D-----------DPIP AqueK491_Aque ----------------SKFGFMIETCVAASRG-LATL-ECPTHPL-----------QPLD AqueK492_Aque ----------------KPFEFKIDQYMSIITSSRPQI-ECGYERDA-------ARNHKVS AqueK493_Aque ----------------KPFEFKIDQYMPIIISSRTQI-ECGYERDA-------ARNHKVS AqueK494_Aque ---------------FSIHAFPMRELQLISLK-QDE-IMCPIHKD------------TVP AqueK495_Aque ------------------FYFNLSQISM--AT-DQV-LTCEKCQ------------AVSP AqueK496_Aque ----------DVE-GSFCVCLPFANCIIPSSH-NDD-LSCPVHG-------------ALK AqueK497_Aque ---------------QEVFIFKLEDCALKALQ-QDT-VYCADYDV------------HVP AqueK498_Aque --VPA-P--TPTP-NVVFYAFQYEECVVRARD-VPY-VKCPVHGE-------------LP LRRK2_Hsap ISQIAPDLILAD------------------------------------------------ LRRK1_Hsap LQELVPELFMTD------------------------------------------------ CG5483_Dmel MAQLAPDVIFAD------------------------------------------------ LRRK2_Mmus ISQIAPDLILAD------------------------------------------------ LRRK1_Mmus LQELVPELFMTD------------------------------------------------ T27C10.5_Cele MRELAPDTVFAD------------------------------------------------ GbpC_Ddis LDILAPDISMVD------------------------------------------------ Pats1_Ddis TDLLVPDLVMSN------------------------------------------------ QkgA_Ddis IDYIAPDICLKK------------------------------------------------ QkgA_C2d_Ddis IDYIAPDICLKK------------------------------------------------ Roco10_Ddis SSRSNPKISRKDSKNLIQSNNNDNNNSLSKKDLKELAKQNKEKEKEKEKDKDKEKEKERK Roco11_Ddis IDYIAPDLSIKK------------------------------------------------ Roco4_Ddis IDYIAPDLCLKK------------------------------------------------ Roco5_Ddis LDSLVPELMMSD------------------------------------------------ Roco6_Ddis FETFVPDVAMSD------------------------------------------------ Roco7_Ddis IYSLAFEVTFNS------------------------------------------------ Roco8_Ddis LCKISPDITLSS------------------------------------------------ Roco9_Ddis LNQLAPDLTMND------------------------------------------------ LRRKd_Spur ISVLIPDMFMKD------------------------------------------------ LRRKc_Spur ISVLIPDMFMKD------------------------------------------------ LRRKb_Spur LQILAPDVTLAD------------------------------------------------ LRRKa_Spur ISVVAPDVMYAD------------------------------------------------ AqueK485_Aque FQGLMPDLLFAD------------------------------------------------ AqueK486_Aque LVDIIPDLLLQD------------------------------------------------ AqueK487_Aque VSEVAPDLAFAD------------------------------------------------ AqueK488_Aque LEYLVPDIMFKD------------------------------------------------ AqueK489_Aque PVAIIPDICDED------------------------------------------------ AqueK490_Aque LRELIPDYLLVD------------------------------------------------ AqueK491_Aque ISSLTPDLVFGD------------------------------------------------ AqueK492_Aque LVDIMPDLLLQD------------------------------------------------ AqueK493_Aque LVDIMPDLLLQD------------------------------------------------ AqueK494_Aque LELLSPDILISD------------------------------------------------ AqueK495_Aque LRRLAPDLLLTD------------------------------------------------ AqueK496_Aque VVQTVPDLSFSD------------------------------------------------ AqueK497_Aque LSTLVPDLLMTD------------------------------------------------ AqueK498_Aque LEYIAPDTLFLT------------------------------------------------ . LRRK2_Hsap --------------------LPRN---IM---LN-ND----------------------- LRRK1_Hsap --------------------FPAR---LF---LE-NS----------------------- CG5483_Dmel --------------------IPDK---HT---IP-SE----------------------- LRRK2_Mmus --------------------LPRN---IM---LN-ND----------------------- LRRK1_Mmus --------------------FPAR---LF---LE-NS----------------------- T27C10.5_Cele --------------------IENA---LT---IH-PD----------------------- GbpC_Ddis --------------------IPIP---R----FN-LS----------------------- Pats1_Ddis --------------------FTGA---K----IP-FD----------------------- QkgA_Ddis --------------------VPT---------FT-DD----------------------- QkgA_C2d_Ddis --------------------VPT---------FT-DD----------------------- Roco10_Ddis VEIYRDDSFLVPIRSLLLDQFSIC---HFIKEID-YR----------------------- Roco11_Ddis --------------------IPI---------LL-ED----------------------- Roco4_Ddis --------------------VPT---------LA-DN----------------------- Roco5_Ddis --------------------IGPN---FT---LE-YK----------------------- Roco6_Ddis --------------------FWGSGSKK----FN-YDQIKMHKEKRILSIKPASFGNNQI Roco7_Ddis --------------------NKFS---V----IP-YE----------------------- Roco8_Ddis --------------------VSSN---KK---VS-KE----------------------- Roco9_Ddis --------------------LRHK---L----ID-FK----------------------- LRRKd_Spur --------------------LSIR---HF----K-QE----------------------- LRRKc_Spur --------------------LSIR---HL----K-QE----------------------- LRRKb_Spur --------------------LEDK---FL---LD-PR----------------------- LRRKa_Spur --------------------LGPS---VL---TE-KS----------------------- AqueK485_Aque --------------------CPAQ---SF---IT-PL----------------------- AqueK486_Aque --------------------LDAD---YL---LK-PE----------------------- AqueK487_Aque --------------------LPSS---IL---YR-KG----------------------- AqueK488_Aque --------------------LSRV---K----LD-RN----------------------- AqueK489_Aque --------------------FVMI---SM---IK-LN----------------------- AqueK490_Aque --------------------LPPS---LQ---LN-QD----------------------- AqueK491_Aque --------------------LPTH---YI---IN-EK----------------------- AqueK492_Aque --------------------FDAD---YL---LK-SE----------------------- AqueK493_Aque --------------------LDAN---YL---LK-SE----------------------- AqueK494_Aque --------------------LDPQ---YH---VS-RD----------------------- AqueK495_Aque --------------------FSGE---LR---LK-KE----------------------- AqueK496_Aque --------------------LVAT---NED--MDKPR----------------------- AqueK497_Aque --------------------LPPN---LI---ID-QS----------------------- AqueK498_Aque --------------------EGRD---VL---LQ-PD----------------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis QFEVRVPPSPPPPPVQQIINNGADDNITTTTLAVNNIKVLESGGSQPPSPRSGKDVTHEL Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap --------------------------------------------ELEFEQ---APEFL-- LRRK1_Hsap --------------------------------------------KLEHSE---DEGSV-- CG5483_Dmel --------------------------------------------CI-------IKGSL-- LRRK2_Mmus --------------------------------------------ELEFEE---APEFL-- LRRK1_Mmus --------------------------------------------KLEHTE---GENSI-- T27C10.5_Cele --------------------------------------------QL-------KRSRM-- GbpC_Ddis --------------------------------------------EVKI-------NKE-- Pats1_Ddis --------------------------------------------QLMI-------EEL-- QkgA_Ddis --------------------------------------------QILY-------ERQ-- QkgA_C2d_Ddis --------------------------------------------QILY-------ERQ-- Roco10_Ddis --------------------------------------------EIEV-------LPDHS Roco11_Ddis --------------------------------------------QVVC-------EEQ-- Roco4_Ddis --------------------------------------------EIEY-------EKQ-- Roco5_Ddis --------------------------------------------DLEI-------IEK-- Roco6_Ddis PIINRLEIIQPTSDESSLIQVEFDHNNQTLVISGTYKYGDLLEIEFES-------PKL-- Roco7_Ddis --------------------------------------------TLKF-------GPQ-- Roco8_Ddis --------------------------------------------DLIY-------QEE-- Roco9_Ddis --------------------------------------------EVELD------PNP-- LRRKd_Spur --------------------------------------------DFTLHM---VSGQS-- LRRKc_Spur --------------------------------------------DFKLHM---VSGQS-- LRRKb_Spur --------------------------------------------KLNFTQ---RAENL-- LRRKa_Spur --------------------------------------------ALE-------IQRL-- AqueK485_Aque --------------------------------------------ESHM-IGI-KVNE--- AqueK486_Aque --------------------------------------------EIKFQE---DKDSL-- AqueK487_Aque --------------------------------------------NIS-------KLEV-- AqueK488_Aque --------------------------------------------MLHDPVDSGNGAGP-- AqueK489_Aque ------------------------------------------VNIKDM-------SSC-- AqueK490_Aque --------------------------------------------SFSYQE-----ARP-- AqueK491_Aque --------------------------------------------LVDR-------GKF-- AqueK492_Aque --------------------------------------------EIKFQE---DKDSL-- AqueK493_Aque --------------------------------------------EIKFQE---DKDSL-- AqueK494_Aque --------------------------------------------SIVMDE--GNPATV-- AqueK495_Aque --------------------------------------------N----L---VFDKS-- AqueK496_Aque --------------------------------------------TL--RI---LEKEV-- AqueK497_Aque --------------------------------------------CFEFNP--KDLSTR-- AqueK498_Aque --------------------------------------------EVL-------KKER-- LRRK2_Hsap -L-GDGSFGS-VYRAAYEG---------EEVAVKIFNK---------------------- LRRK1_Hsap -L-GQGGSGTVIYRARYQG---------QPVAVKRFHIKKF-KNF--------------- CG5483_Dmel -L-GRGAFGF-VFKANCKSA---------LMAFKVAVG---------------------- LRRK2_Mmus -L-GDGSFGS-VYRAAYEG---------EEVAVKIFNK---------------------- LRRK1_Mmus -L-GQGGSGTVIYQARYQG---------QPVAVKRFHIKKF-KNS--------------- T27C10.5_Cele -L-GRGAFGF-VFRATVRQPNG----ELCEVAQKMLEPVDP-GPG--------------- GbpC_Ddis -V-GRGAFGI-VYEAEWMS---------EWIALKKLLLPSS-TDT--------------- Pats1_Ddis -I-GEGGAAL-VYRARWQG---------QTVAVKKLKTIEN-LDS--------------- QkgA_Ddis -I-GEGGFGL-IHKGKLISN-------KSDIAIKSLILCNS-NNN--------------- QkgA_C2d_Ddis -I-GEGGFGL-IHKGKLISN-------KSDIAIKSLILCNS-NNN--------------- Roco10_Ddis NQNENGTSTQ-SMMGMYGK---------QFVNIKVFNAPLL-G----------------- Roco11_Ddis -I-GVGGFGL-VHKGKLILQD-----KSLVVAIKSYIVGNS-S----------------- Roco4_Ddis -I-GKGGFGL-VHKGRLVKD-------KSVVAIKSLILGDS-E----------------- Roco5_Ddis -V-GEGGFGI-VYKGKLRG---------QLVAIKQITIDS-------------------- Roco6_Ddis -I-GRGASGK-IYRANLND---------TMVAVKQLEVVG-------------------- Roco7_Ddis -L-GSGSYAN-VYRGIWNG---------SEVAIKVLNFDDG------------------- Roco8_Ddis -I-GVGGFSR-VYKGIYKN---------NTVAIKQFNFERM-DLI--------------- Roco9_Ddis -I-GEGGTAT-VYKGKWRQ---------SDVAIKLLKTDVV------------------- LRRKd_Spur -L-GQGGFGE-VFRAKFRG---------ETVAAKTMLPSRLLKNRMFSSASEGYASCAST LRRKc_Spur -L-GQGGFGE-VFRAKFRG---------ETVAAKTMFPSRLLKNQMYSSPSEGYASCAST LRRKb_Spur -L-GDGSFGS-VYKGTYRDK---------PVAVKVFSKGG-------------------- LRRKa_Spur -L-GSGTFGL-VFQGVMARASE----HRRPIAAKMLQPYPP-GQG-A------------- AqueK485_Aque ---SKGMF----LRHYF--------------SEKIMEPAK-------------------- AqueK486_Aque -L-GEGGFGK-VYRGKCRG---------KSVAIKKYLTR--------------------- AqueK487_Aque -L-GSGGFGS-VYKGLIEEGQ-------VTVAIKEFSSIAG-KME--------------- AqueK488_Aque -V-GCGCFGV-VYHKRLQLEQYDP-DISREVAVKEFRSSDM-D----------------- AqueK489_Aque -L-TRPPLET-VFKGEYG---------SVPIAVKPYPPPND------------------- AqueK490_Aque -V-YRDNSTI-LYDGTFSG---------NPATVKKHLFSES------------------- AqueK491_Aque -V-ASGSFGE-IYHGAIYPHLSASDDEGREVAIKIDKQDRK------------------- AqueK492_Aque -L-GEGGFGK-VYRGKFHG---------KSVAIKKYLTR--------------------- AqueK493_Aque -L-GEGGFGK-VYRGKFRS---------KSVAIKKYLMR--------------------- AqueK494_Aque -L-GKGGFGE-VFKALYNEK---------SVAIKVFSPRVA-EL---------------- AqueK495_Aque -E-KSLIEKQ-VYKGTYYN---------QPVAIKVFPIDSS------------------- AqueK496_Aque -L-GKGGYGF-VCTGELKGPTGS---PPELVAVKVFLTNLE-GKI--------------- AqueK497_Aque -L-GRGGAGA-VYKGKYRNV---------PVAVKEFLTQSQ-ADA-F------------- AqueK498_Aque -L-GRGAFAT-VYHAQIKRKLPNGQIHFEDVAIKALGNKGE-DLD--------------- * LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ----A------------------------------------NV----------------- CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ----A------------------------------------NA----------------- T27C10.5_Cele -GRPS------------------------------------ALAAY-------------- GbpC_Ddis --TNL------------------------------------NGNGE-------------- Pats1_Ddis --P--------------------------------------------------------- QkgA_Ddis --NNS------------------------------------NNNNN-------------- QkgA_C2d_Ddis --NNS------------------------------------NNNNN-------------- Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis --DSTSFNNLNSLTISPSNSSLSISLSSSTSSLSPPIVNNNNNNNNLNNNLNNLNNNNKL Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur SSSTS------------------------------------NRTGE-------------- LRRKc_Spur PSSTS------------------------------------NMTGE-------------- LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur -GNTD------------------------------------RRRYD-------------- AqueK485_Aque --------------------------------------------RH-------------- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque --D-S------------------------------------LS----------------- AqueK497_Aque -QDED------------------------------------ELPPG-------------- AqueK498_Aque ----D------------------------------------DD----------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis YIQQQQQTQQNQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQNQQQPKILQRNLST Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ---------------------------------------------HTSLRLLRQELVVLC LRRK1_Hsap --------PADTM---------------------LRHL--RATDAMKNFSEFRQEASMLH CG5483_Dmel ------------K---------------------WDRD--PLQHSCKAYCTARQELAVLL LRRK2_Mmus ---------------------------------------------HTSLRLLRQELVVLC LRRK1_Mmus --------PADTM---------------------LRHL--RAMDAMKNFSDFRQEASMLH T27C10.5_Cele -----KA-AAD-K---------------------WKRD--SMEFACRAYCTSRQELSLLS GbpC_Ddis -----VM-VYD-----------------------DPDQ--LIEDRLRVFREFRHEVYYMS Pats1_Ddis -----------------------------------IEI--NDISLSKAFNEFRRECWVMS QkgA_Ddis -----SNNSNNF----------------------KNNN--NEDEFIEKFQEFQHEVFIMS QkgA_C2d_Ddis -----SNNSNNF----------------------KNNN--NEDEFIEKFQEFQHEVFIMS Roco10_Ddis ------------------------------------AD--FQNNCARILSSFRHEALSLY Roco11_Ddis -----------------------------------------ASDIIRKFQEFHHEMYIMS Roco4_Ddis ----------------------------------------GETEMIEKFQEFQREVFIMS Roco5_Ddis -------------------------------------G--QAEAASEIYREFRREVWLSN Roco6_Ddis ------------------------------------------EDAPRIFSEFRREIHVMS Roco7_Ddis -----------------------------------------HANTTEKYREFRNEAHITG Roco8_Ddis SSLSSNSSQGED----------------------SMNQ--ISSGKLNAINEFRREVWLMS Roco9_Ddis -----------------------------------------GSDFSKVFAEYRREIFCLS LRRKd_Spur -----STSTE------------------------NDSL--EAAMLMESFHKLRNEVAIMA LRRKc_Spur -----STSTENDS---------------------CDSL--EAAMLMDSFHKLRNEVAIMV LRRKb_Spur --------------------------------------------ESHPHRLLRQEVTVLR LRRKa_Spur -----NDN-TKWH---------------------RD----PLRFSCEAYRTARKELSIIN AqueK485_Aque -----KG-A----------------------------Q--KTFYLKKHITKLYQDFDLLK AqueK486_Aque --------------------------------------------TEEAFNELRSEAKVLQ AqueK487_Aque ----------------------------------EDTLIGHELNAWDIYINGSREARMMH AqueK488_Aque ----------------------------------YD----AELEVVKSYADMRYELNKLC AqueK489_Aque ------------------------------------------RSANNPFLSFWHEITTLQ AqueK490_Aque ------------------------------------------KSYSVPLSAMRQELEMLS AqueK491_Aque ------------------------------------HF--NMETAAKAYTEIRAEVALLK AqueK492_Aque --------------------------------------------QEEAFNELRHEAKLLQ AqueK493_Aque --------------------------------------------QEEAFNELCHEAKLLQ AqueK494_Aque -------------------------------------------HSTTPNQLIRQEVSILS AqueK495_Aque ------------------------------------------ANHFTVLRLHRSELSVLT AqueK496_Aque --------SAELL---------------------EEAA--KDSQLRSAYKEIRQEVNFLS AqueK497_Aque -----GIH-TYHD---------------------DDSI--SSGEALFLYRDMRQEVTVLA AqueK498_Aque --------DEDISLDEEEERPGGDDEYDGENAREPPPI--QRSAIISGFNNLKKELSILS : LRRK2_Hsap ----HLHHPSLISLLAAGIRPR-MLVMELASKGSLDRLL-----QQDK------------ LRRK1_Hsap ----ALQHPCIVALIGISIHPL-CFALELAPLSSLNTVL-----SENARDSS-------- CG5483_Dmel ----TLKHPNIVPLVGICIKPL-ALVLELAPLGGLDALL-----RHYRRSG--------- LRRK2_Mmus ----HLHHPSLISLLAAGIRPR-MLVMELASKGSLDRLL-----QQDK------------ LRRK1_Mmus ----ALQHPCIVSLIGISIHPL-CFALELAPLGSLNTVL-----SENAKDSS-------- T27C10.5_Cele ----RMKHPNVIGLVGVCTFPL-SLVVELAPLGALNQLL-----GSHRKAG--------- GbpC_Ddis ----GLNHPNVMKISGFCIQPL-CMALEYVRYGSLYSLL-----SNS---S--------- Pats1_Ddis ----ELEHPNIVQLKGLCLDPL-CIVTEYLPHGNLYSFL-----HKPE------------ QkgA_Ddis ----NLNHPNIVKLYGLMHNPP-RMVMEYVEHGDLYHLC-----QDKER-Y--------- QkgA_C2d_Ddis ----NLNHPNIVKLYGLMHNPP-RMVMEYVEHGDLYHLC-----QDKER-Y--------- Roco10_Ddis ----NFRHSNVLSIIGISMNPI-AIITENPTFGSKGSTTLSEYIQDRQK-H--------- Roco11_Ddis ----SLNHLNIVKLFGSMQNPP-RMVMEFAPHGDLYHFL-----EKKK------------ Roco4_Ddis ----NLNHPNIVKLYGLMHNPP-RMVMEFVPCGDLYHRL-----LDKA------------ Roco5_Ddis ----TLTHPSIVSLKGYCLDPC-CIVMEYIPNGTLYSHL-----RK--S-F--------- Roco6_Ddis ----DLKHSNVVNLLGFTLSPF-TMVMEYIDCGDLHKFL-----HSPIGDQ--------- Roco7_Ddis ----ELRHANTVSLMGVSLSPF-CLVTELLQYGDLAKFI-----RNTA------------ Roco8_Ddis ----GLSHSNIVLMKGFCFEPY-AIVMEYMDIGSLSSFL-----KKKKEDG--------- Roco9_Ddis ----SFIHDNILDLKGFCLEPL-AIITEFQSGGNLYDYI-----HDLK------------ LRRKd_Spur ----KLDHPYIVNLVGVSIRHL-CFAMDYAPLGDLRSYL-----FAEHQSARPHFV---K LRRKc_Spur ----KLDHPCIVNLVGVSIRHL-CFAMDYAPLGDLQSYL-----FAEHQSARPHFV---K LRRKb_Spur ----HLQHPSLVSMEGVGLNPR-ILVMELAPLGSLNTLL-----ASGRIKN--------- LRRKa_Spur ----NLDHPHIVPLLGFCRHPM-CLILELAPQGALDTRM-----ENFKRVGA-------- AqueK485_Aque ----NLSTPHIISSLGFHYSVP-VLALELSPLGSVRKYL-----NDGNKLL--------- AqueK486_Aque ----ESHHPFLVCLVGVSVHPLMALILEEAPMGSFERHL-----IKKS------------ AqueK487_Aque ----QLQHKNILSLVGLAFQPL-RLILELAPLGDLKNSL-----KPFRQEK--------- AqueK488_Aque ----MMEHDFVVEFVGLLTNPW-SFILEWAPLMSLEKIR-----KSYEEQFKTHKP---- AqueK489_Aque YATQTDQCPYIIDPLLATTDPF-SLVFSFAMFCSMEDVI-----LEHT------------ AqueK490_Aque ----LLSHPNIIKAYGYCFSPP-SLVIERSPLGTLLQKL-----SDNE------------ AqueK491_Aque ----DLDHEYIINFIGLTLQPL-CFMLEWASKGSLHGIL-----QSYYRTD--------- AqueK492_Aque ----KSYHPSIVCLVGVNVHPLTALILEEAPMGSLDRHL-----IKES------------ AqueK493_Aque ----KSHHPFIVCLVGVNVHPLTALILEEAPMGSLERHL-----IKES------------ AqueK494_Aque ----QMDHPNIIGLVGVCLRPKPMLLIEYAELGSLSSFS-----PYS--T---------- AqueK495_Aque ----NISHQYLISTAGFLTAPL-SIVFPLAPLGSLQDHL-----DLCP------------ AqueK496_Aque ----TLKHQNITKLIGVRTKPVYCLLLELAPMKSLRSML-----KDYQLCK--------- AqueK497_Aque ----QLSHPNIVSILGVSLRPM-CIALELAPMGSLFGIL-----DKKLEAIKTAQADLPT AqueK498_Aque ----PLRHPYIIQLFGVSARPL-GLVLELAPKGSLKSLL-----KEYSEAQ--------- : LRRK2_Hsap -------ASLTRTLQHRIA----------LHVADGLRYLHSA--MIIYRDLKPHNVLLFT LRRK1_Hsap ------FIPLGHMLTQKIA----------YQIASGLAYLHKK--NIIFCDLKSDNILVWS CG5483_Dmel -------AHMGPHTFQTLV----------LQAARAIEYLHRR--RIIYRDLKSENVLVWE LRRK2_Mmus -------ASLTRTLQHRIA----------LHVADGLRYLHSA--MIIYRDLKPHNVLLFT LRRK1_Mmus ------FMPLGHMLTQKIA----------YQIASGLAYLHKK--NIIFCDLKSDNILVWS T27C10.5_Cele -------TKLSLGVIKESA----------VQVARALEYLHSA--HIIYRDLKSENVLGWR GbpC_Ddis -------IEISWGLRLQIA----------SEIAKGMQHLHSHNPPVIHRDLKSPNILLNG Pats1_Ddis -------MEFSWLFRLKVA----------LDISSGMAFLHSSTPPIIHRDLKSPNILLAS QkgA_Ddis -------ASLGWTLKLRLM----------IDIAKGIGYMQNQNPPIVHRDLRSPNIFLKS QkgA_C2d_Ddis -------ASLGWTLKLRLM----------IDIAKGIGYMQNQNPPIVHRDLRSPNIFLKS Roco10_Ddis -------PEIPWNIKLKIA----------LDIARAMDKLNSHSPPFLLTNLTSSGIILEK Roco11_Ddis --------NIKWSFKVRLM----------LDIAKGIEYLQNQNPPIVHRDLRSPNIFLFS Roco4_Ddis -------HPIKWSVKLRLM----------LDIALGIEYMQNQNPPIVHRDLRSPNIFLQS Roco5_Ddis -------SSITWQLKLKIA----------INIADAIKHMHGFTPKICHRDLKSPNILMLS Roco6_Ddis -------LNGNWALILKLA----------LDIAKGMEFLHSVTPPLLHRDLKSPNVLLSM Roco7_Ddis -------ETFSWGTVLKLA----------IDVAKGMNFLHSCKPMIVHRDLKSANILLGG Roco8_Ddis -------QVLDWQMLLKIV----------TDIASGMAFLHNITPPLVHRDLKSPNILLAS Roco9_Ddis -------NPLDWQLRIKIA----------KGIAASLQTLHDSRPSVVHRDLKSPNILLSS LRRKd_Spur RNIV-LEPVLSRMLTYKIS----------LQVASAVGYLHRK--DIIYCDLKTDNILLFS LRRKc_Spur RNIV-LEPVLSRMLTYKIS----------LQVASAVGFLHSK--DIIYCDLKTDNILLFS LRRKb_Spur -----------RNLQHRIA----------MQVAEGLAFLHKN--RIVYRDLKPDNVLIFS LRRKa_Spur --------RLTPHTLQELV----------VQVSSAVAYLHSK--DIIYRDLKAENVLVWK AqueK485_Aque -----------QSGVHQIALQLLKNWAKEYRVLSAIKYLDTN--SLNYHCLTCDNVLLWL AqueK486_Aque -------TPIPRLTMFRIA----------AQVAAALRFLHQH--GIIFRDLKAANVLLWS AqueK487_Aque -------IKLNCRTLKQLI----------YQVADA------------------------- AqueK488_Aque -----EYYYLCPVSLYLIL----------LQVCDGLHYLHAPPIGIIHSDLKLSNILAYR AqueK489_Aque -------ISVSPFLRMRIV----------YQLASALKTLHSL--KIIHRNVCLENIIVYS AqueK490_Aque -------QKISRLVRFHIS----------CQVASALAYLHKH--NVIYRTLKSDSVLTWS AqueK491_Aque -------SKVSPWTLVEAG----------RQVANGLSYLHSR--NVVYYDLKSPNILVFE AqueK492_Aque -------TPIPRLTMFRIA----------AQVAAALRFLHQH--GIIFRSLKAANVLLWS AqueK493_Aque -------TLIPRLTMFRIA----------AQAAAALRFLHQH--GIIFRSLKAANVLLWS AqueK494_Aque ---------VSPSLKHRIA----------MQVASALAFLHKN--NIIYRDLKPSNILIFS AqueK495_Aque -------SGIGDKISHVLL----------HQVAQGLQYLHSL--HIIHRDIKPGNILVWS AqueK496_Aque -------LTMEPITLKQCA----------KQISDGLNYLHTH--QIVHLDMKSPNVLVWE AqueK497_Aque ANIKMPGGVLGHQISARIA----------LQVALATRYLHKI--GIVYRDLKSDNVLIWS AqueK498_Aque -------THIQSSAMQAVT----------LQISDALKYLHDL--RIIYRDLKSDNVLVWQ . LRRK2_Hsap LYP-------------------------N-------------------AAIIAKIADYGI LRRK1_Hsap LDV-------------------------K-------------------EHINIKLSDYGI CG5483_Dmel LPQPHTE------------------DSPR-------------------NLVHIKIADYGI LRRK2_Mmus LYP-------------------------N-------------------AAIIAKIADYGI LRRK1_Mmus LSA-------------------------K-------------------EHINIKLSDYGI T27C10.5_Cele FPAPF---------------------SPQ-------------------TDVLLKLGDYGI GbpC_Ddis IT-------------------------EG-------------------QNSVATIIDFGT Pats1_Ddis IN-------------------------EN-------------------AQTIAKVVDFGL QkgA_Ddis LD-------------------------EN-------------------SPVCAKIADFGL QkgA_C2d_Ddis LD-------------------------EN-------------------SPVCAKIADFGL Roco10_Ddis SNDHQSSGNGLE---------------IE-------------------PFVNAKIIDFSQ Roco11_Ddis LD-------------------------EN-------------------APVCAKVADFGL Roco4_Ddis LD-------------------------EN-------------------APVCAKVADFGL Roco5_Ddis D--------------------------MN-------------------AAVVCKVSDFGE Roco6_Ddis KD----------------------------------------------GVYTAKVGDFGL Roco7_Ddis SS-------------------------M-D-------------------NLVAKVGDFGL Roco8_Ddis HP-------------------------TNP------------------NEISAKVSDFGL Roco9_Ddis KD-------------------------S-L------------------T-MECHLCDFSL LRRKd_Spur SDV-------------------------N-------------------EDVNIKLIDYGI LRRKc_Spur SDV-------------------------N-------------------EDVNIKLTDYGI LRRKb_Spur LAL-------------------------G-------------------TLQNAKISDYGI LRRKa_Spur FPQPYS------------------P-NPA-------------------DPIKVKLADYGI AqueK485_Aque LE-----------------------------------------------PVTVKLSDSGL AqueK486_Aque LDE-------------------------T-------------------SLCHSKKEKC-- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque FPKMDHNCCSSVQGRGYCSECLPEP-GHS-------------------YKVLVKLGDMGV AqueK489_Aque LS-------------------------LDE-------------------QVNIKLGGFSR AqueK490_Aque LE-------------------------FE-------------------DEVSVKLAHFDR AqueK491_Aque FP-------------------------SADESLRVSLESSPVLDKLGKFPVHVKITDLGI AqueK492_Aque LDE-------------------------T-------------------SLCHSKLTDFGI AqueK493_Aque LDE-------------------------T-------------------SLCHSKLTDFGI AqueK494_Aque LSL-------------------------N-------------------SPVNAKLSDYGI AqueK495_Aque LTL-------------------------S-------------------DGILVKITDYGS AqueK496_Aque FPIAGMPRK-------------ERL-KYA-------------------GNVWLKIADYGI AqueK497_Aque LDV-------------------------N-------------------ESVNAKLADYGI AqueK498_Aque FPSPYDVLV-------------PALPVHT-------------------DVVKVKLSDYGI LRRK2_Hsap AQYCCRM-GI----KTS-EGTPGFRAPE------VAR---GNVIYNQQADVYSFGLLLYD LRRK1_Hsap SRQSFHE-GA----LGV-EGTPGYQAPE------IRP----RIVYDEKVDMFSYGMVLYE CG5483_Dmel SRQTAPS-GA----KGF-GGTEGFMAPE------IIRYN-GEEEYTEKVDCFSFGMFIYE LRRK2_Mmus AQYCCRM-GI----KTS-EGTPGFRAPE------VAR---GNVIYNQQADVYSFGLLLHD LRRK1_Mmus SRQSFHE-GA----LGV-EGTPGYQAPE------IRP----RIVYDEKVDMFSYGMVLYE T27C10.5_Cele SRSVLPSGGA----KGF-GGTEGFMAPE------IVRFN-GEEEYTQKVDCFSFGMFLYE GbpC_Ddis STALYGG-AAL----IRCVDQPLWLGPE------VLA----GTAYSEPSDVYSFGIILWE Pats1_Ddis SGLQHTI--TN----RG-VENPLWLAPE------ILNK---TKEASTQTDVYAFGVILWE QkgA_Ddis SQQSVYS--VS----GL-LGNFQWMAPE------TIGVE--DESYTEKVDTYSFAMILFT QkgA_C2d_Ddis SQQSVYS--VS----GL-LGNFQWMAPE------TIGVE--DESYTEKVDTYSFAMILFT Roco10_Ddis SSFLPSL--F-----PTSTTPKSYHSPE------VLQ----KLNYHENSDVYSFGIILYE Roco11_Ddis SQQSLYS--VS----GL-LGNFQWMAPE------TIGA---EESYTEKIDTYSFSMILFT Roco4_Ddis SQQSVHS--VS----GL-LGNFQWMAPE------TIGAE--EESYTEKADTYSFAMILYT Roco5_Ddis TRAVVTS-ALG----RDKLSNPIWLSPE------IMR----GDEYTEKADVYSFGIVLWE Roco6_Ddis SSRMFIQ-ALKHKLRNFPVGNITWVAPE------ILR----EEEYTVKSDVYAFGLILHE Roco7_Ddis SIKPIGK-EVK----GRKVWNWRWLAPE------CMG----DGQYTEKIDIYSYAIVLWE Roco8_Ddis SRSIVQN-FSS----KV-VDNPTWQSPE------VLK----GMEYNEKSDIYSFGMILWE Roco9_Ddis SGFSTTV--AN----RS-VQNPVWLAPE------VIN----NELCSDKSDVYAYGVILFE LRRKd_Spur SKKYDLM-GA----MGM-AGTPGFCAPE------ILQ----GKTFDEKVDWFSYGMFLYH LRRKc_Spur SRKYDLM-GA----MGM-AGPPGFCAPE------ILQ----GKVFDEKVDWFSYGMFLYH LRRKb_Spur SRFATPY-GL----KSS-EGTPGYRAPE------VIRG---TSNYNTEVDIYSFGILLYE LRRKa_Spur SVTALPS-GT----KGY-GGTPGYMAPE------IVQYD-GKETYNEKVDCFSFGMFMFE AqueK485_Aque LHSPADCI-L----CST-LNTT-V------------TAS-TRKAKMFRFNLIMFGLFLYE AqueK486_Aque ---MV-----------V-SGAKGFQSPLEGYPLDDFPQTE--EDKSQPLD-NSGEMILWE AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque SVNPAAH-NH-----DA-LGV-KRFAPE------ASNT-----KLTEK------------ AqueK489_Aque SCLEMSQ-GL-----A-VGEHGRFPAPE------MSNY---LYEYDQRADVFSFAFTSYE AqueK490_Aque AAFSTPT-GIL----SK-TDFSFYPAPE------MVRYE-FSEEYTEKVDIYSFGILLYE AqueK491_Aque SRKITPG-GVV----G-YKGTPAFMAPE------ILRYV-GKEACTEKVDVFSFGMFMYE AqueK492_Aque ATHLAPL-GV----MGI-QGDKCVIAPE------VLYIGQKRTIYNHKADIFSFGMLLYQ AqueK493_Aque ATHLAPL-GV----MGI-QGDKSVIAPE------VLYIGQKRTIYNHKADIFSFGMLLYQ AqueK494_Aque STFATTT-GL----NQD-IGTAGYKAPE------ILKAKTSKMPYNTMVDIYSFGIVLFQ AqueK495_Aque SYYIDTF-GC----KGS-RGTEDYMAPE------LYLSA-RKRNYDEKVDIFSFGILLFN AqueK496_Aque SQVATSM-MMKV-TTNQ-PGTPGYMAPE------LFET--GQEIYSTKVDVFAYGMTLYE AqueK497_Aque SRFANPG-GI----KGE-EGTPGYMAPE------AIKRRGEDQAFDEKVDIFSFGMLLFE AqueK498_Aque SQFASTQ-GA----KGL-VGTPGFMAPE------ILMYY-GKEAYNEKVDIFSFAMLIYE LRRK2_Hsap ILTT-GGRIVEGLKF------PNEF----------------------------------- LRRK1_Hsap LLSG-QR-PALGHH-------QLQI----------------------------------- CG5483_Dmel NISL-RQ-PFEGHES---------I----------------------------------- LRRK2_Mmus IWTT-GSRIMEGLRF------PNEF----------------------------------- LRRK1_Mmus LLSG-QR-PALGHH-------QLQI----------------------------------- T27C10.5_Cele LLTL-KF-PFESEEH---------V----------------------------------- GbpC_Ddis LYTR-AH-PFDEFQ-FGQ--WMSKL----------------------------------- Pats1_Ddis LVTR-KD-YFGEIG-F-----MTLI----------------------------------- QkgA_Ddis ILTG-EI-PFDEYS-FG---KMQFI----------------------------------- QkgA_C2d_Ddis ILTG-EI-PFDEYS-FG---KMQFI----------------------------------- Roco10_Ddis LLTR-SI-AFQDHD---------RF----------------------------------- Roco11_Ddis ILTG-EC-PFDEFTSFG---KMEFI----------------------------------- Roco4_Ddis ILTG-EG-PFDEYS-YG---KIKFI----------------------------------- Roco5_Ddis ILTG-LL-PFDEYP-VAHSSFMYQL----------------------------------- Roco6_Ddis LLTR-KH-PYREFN-YSM---VSLQ----------------------------------- Roco7_Ddis IITR-DL-PFEEYVDQL--KWNSII----------------------------------- Roco8_Ddis CYHL-EL-PFDEFD-FK---FMSTL----------------------------------- Roco9_Ddis LLSR-TR-FFSNIT------FMSEV----------------------------------- LRRKd_Spur LMTG-LV-PYYDQHS------RIEI----------------------------------- LRRKc_Spur LMTG-LV-PYYDQHS------RIEI----------------------------------- LRRKb_Spur LVSEGHR-PFEEMEF------RTEI----------------------------------- LRRKa_Spur LMSL-QR-PFECLVGKDVGRLSEVI----------------------------------- AqueK485_Aque LTLH-RR-AYEDIMS---------L----------------------------------- AqueK486_Aque AYSR-AT---------------LRQ----------------------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ILTR-KK-LKC-RK---G----VRF----------------------------------- AqueK490_Aque LVAR-WQ-PFTSDKT--------------------------------------------- AqueK491_Aque LLAQ-QF-PFERQN-LMH----NQI----------------------------------- AqueK492_Aque MIAR-RH-PFHNVQ-------PVRI----------------------------------- AqueK493_Aque MIAR-RH-PFHNVQ-------PVRI----------------------------------- AqueK494_Aque LVTDGHT-PFEELMP-------HEK----------------------------------- AqueK495_Aque VVTG-KK-FAPNFN-------RSRHEAGGRREAFLSIPHLSIIASAIEEQRLVGSSNQSP AqueK496_Aque IISL-QA-PFQKQE-------AMKR----------------------------------- AqueK497_Aque LITG-QR-PFESMST------GQEV----------------------------------- AqueK498_Aque MITF-RL-PFEHLT-------PSQA----------------------------------- LRRK2_Hsap -DELEI---QGKL-P-D--------PVKE------------------------------- LRRK1_Hsap -AKKLS---KGIR-P-V--------LGQP------------------------------- CG5483_Dmel -KECIL---EGSR-P-A--------LTQR------------------------------- LRRK2_Mmus -DELAI---QGKL-P-D--------PVKE------------------------------- LRRK1_Mmus -VKKLS---KGIR-P-V--------LGQP------------------------------- T27C10.5_Cele -KERML---DGAR-P-V--------LLPH------------------------------- GbpC_Ddis -EDEII---RGLR-P-T--------IPPT------------------------------- Pats1_Ddis -EEKVI---NGER-P-K--------IPED------------------------------- QkgA_Ddis -NLIRE---ENLR-P-T--------LPFD------------------------------- QkgA_C2d_Ddis -NLIRE---ENLR-P-T--------LPFD------------------------------- Roco10_Ddis -SNIVI---SGQR-P-S--------IPLD------------------------------- Roco11_Ddis -RKIRE---EDLR-P-T--------IPSD------------------------------- Roco4_Ddis -NMIRE---EGLR-P-T--------IPED------------------------------- Roco5_Ddis -EDEIT---NGLR-P-T--------IPQN------------------------------- Roco6_Ddis -EDAIK---NGLR-P-T--------ISPS------------------------------- Roco7_Ddis -EDKIM---KGLR-P-T--------IPNE------------------------------- Roco8_Ddis -EDNIL---SGLR-P-S--------INQN------------------------------- Roco9_Ddis -EGLIT---EGVR-P-S--------LPSH------------------------------- LRRKd_Spur -ELAVN---EGRK-P-T--------FNFH------------------------------- LRRKc_Spur -QLAVN---EGRK-P-T--------FNFH------------------------------- LRRKb_Spur -DEAVI---KGQHLP-P--------ISQG------------------------------- LRRKa_Spur -KQLIK---DGQR-P-V--------LSRK------------------------------- AqueK485_Aque -PTLILALYHQQL-VLNVEADLKHNQSQV------------------------------- AqueK486_Aque -MK-II---EEES-P-G--------YLDNHKTVARMIKNFKFKDDTHIVEDLTATTTDES AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque -QTATG---NADR-P-N--------LKPL------------------------------- AqueK490_Aque -----A---MAHK-P-K--------LTGL------------------------------- AqueK491_Aque -EKLVV---DGAR-P-S--------IQNK------------------------------- AqueK492_Aque -DTKVV---QGDR-P-S--------TVDM------------------------------- AqueK493_Aque -DTKVV---QGDR-P-S--------TVDM------------------------------- AqueK494_Aque -DKAVE---EGRL-I-K--------DPSY------------------------------- AqueK495_Aque ATLLLK---DGVH-P-A--------AREG------------------------------- AqueK496_Aque -NAEVR---AGKR-P-P--------TGN-------------------------------- AqueK497_Aque -NRAVI---QRER-P-Q--------VSEG------------------------------- AqueK498_Aque -NQANE---NGAR-P-T--------LKRI------------------------------- LRRK2_Hsap -----Y---GCA-------------------PWPMVEKLIKQC----------------- LRRK1_Hsap ---------EEV-------------------QFRRLQALMMEC----------------- CG5483_Dmel ---------ETQ-------------------FPTCCLDLMVLC----------------- LRRK2_Mmus -----Y---GCA-------------------PWPMVEKLITKC----------------- LRRK1_Mmus ---------EEV-------------------QFHRLQALMMEC----------------- T27C10.5_Cele ---------ELL-------------------LPTPMLDLLVHC----------------- GbpC_Ddis ----C---------------------------PPEYVELIQSC----------------- Pats1_Ddis -------------------------------CPEMYSKLIVEC----------------- QkgA_Ddis -------------------------------CDPRLSNLIQLC----------------- QkgA_C2d_Ddis -------------------------------CDPRLSNLIQLC----------------- Roco10_Ddis -------------------------------CLPSFADLIKDC----------------- Roco11_Ddis -------------------------------CPPTISNLIELC----------------- Roco4_Ddis -------------------------------CPPRLRNVIELC----------------- Roco5_Ddis ----SV-----C-------------------GHPDFITLITDC----------------- Roco6_Ddis ----YT---QTV-------------------TGHEYCGLIQDC----------------- Roco7_Ddis -------------------------------CPPDMKQLITDC----------------- Roco8_Ddis -------------------------------CNRMYSSLITKC----------------- Roco9_Ddis -------------------------------NLPEYDSLLNIC----------------- LRRKd_Spur ----EYTMPPKQ-------------------VFPALGALMESC----------------- LRRKc_Spur ----EYKMPPRQ-------------------VFPALGALMESC----------------- LRRKb_Spur ---------GVA-------------------PWPDLQELIDHC----------------- LRRKa_Spur ---------EKS-------------------YPTYMLDLLSWC----------------- AqueK485_Aque ---------KAC-------------------YKLCMQSVIQLC----------------- AqueK486_Aque ESSPSA---SADDTRETFKPFETSYTPNDHSPDPR-SSIISSMSSAEESQMQSESGEDVP AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ---------DPA-------------------YPIPLYTTLDQC----------------- AqueK489_Aque ----NG-------------------------LCPYFTPLLDKC----------------- AqueK490_Aque ----ST-----Y-------------------GFGSLVKLMEEC----------------- AqueK491_Aque ----V--------------------------TSACIVTLPIDI----------------- AqueK492_Aque ----PI---AET-------------------GYFFLTRLMEKC----------------- AqueK493_Aque ----PI---AET-------------------GYFFLTRLMEKC----------------- AqueK494_Aque --------YGGA-------------------PWPDMHDIIRHC----------------- AqueK495_Aque ----H---ISTC-------------------ISTCMQVILEDC----------------- AqueK496_Aque --------KEKH-------------------TPLLLQDLMRLC----------------- AqueK497_Aque --------NMEP-------------------SFPGMIELMEDC----------------- AqueK498_Aque ---------DLP-------------------CPVLIRELMVWC----------------- LRRK2_Hsap -------LKENPQERPTSAQVFDILNSAELVCL-TR---------RILLPKN-------- LRRK1_Hsap -------WDTKPEKRPLALSVVSQMKDPTFATF-MY---------ELCCGKQ-------- CG5483_Dmel -------WHEQPRRRPTASQIVSILSAPECIHL-LD---------VVAMPHS-------- LRRK2_Mmus -------LKENPQERPTSAQVFDILNSAELICL-MR---------HILIPKN-------- LRRK1_Mmus -------WDTKPEKRPLALSVVSQMKDPTFATF-MY---------MLPCGKQ-------- T27C10.5_Cele -------WSAHPESRPSSSQLVGFCAAPEFTHL-LD---------VCELGEA-------- GbpC_Ddis -------WTHEPNSRPTFTSIVEILGQIKKKFAPLPFTHPPHIRNMMRKSRS-------- Pats1_Ddis -------WQTDASQRPKFSEIEDRLIKIAEAMF-PD--------IHL-------SNIYQQ QkgA_Ddis -------WSTNPKKRPSFTFIIKELLEIRIDSI-QT--------S--------------- QkgA_C2d_Ddis -------WSTNPKKRPSFTFIIKELLEIRIDSI-QT--------S--------------- Roco10_Ddis -------WSGEPLNRPSPSKIISQLYTIKKEIE-SK--------EHSY------KSL--- Roco11_Ddis -------WSGDPKKRPHFSYIVKELTNFYYNLN-L----------------------SPI Roco4_Ddis -------WSGDPKKRPHFSYIVKELSELRNGNT-TS--------T------------TTN Roco5_Ddis -------WQNDPLKRPTFIDIHSRLLIMSGL-N-PA--------TATT------T-N--- Roco6_Ddis -------WDSDIDRRPTFNKIVKRIKQIIGRD--VN--------NILMVNGV-------- Roco7_Ddis -------WSGDPKKRPSFNSILERLSTMQKTFN-LN--------ERLEFCKQL-PPINED Roco8_Ddis -------WNADPNLRPSFNSILKTLNEIK------------------------------- Roco9_Ddis -------WAQDPTCRPSFIEITKKLEEIELILK-TH--------TPV-------EPVYTE LRRKd_Spur -------WQNKPGERPHGETTLQLLSEPSFLCL-RR---------VVEVEEE-------- LRRKc_Spur -------WQDKPGKRPHGKTILQLLSEPSFLCL-RR---------VVEVEEE-------- LRRKb_Spur -------TEHVPESRPTAQEAFEKLSSAEMLCL-KQ---------ASALLSG-------- LRRKa_Spur -------WAQDSRDRPSMEQIKDVSKTAEFANL-LE---------VLSLEEK-------- AqueK485_Aque -------IGMGEL---TFRGLESRLSLCAGEN-------------------N-------- AqueK486_Aque LYDSSSRSSLEPIENPSTSEVDAR------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque -------WQQEPNARPSAKTIRNYLQKTTGLLV-KN---------RFQLPAKNMYHLL-- AqueK489_Aque -------WNNDPHKRPYFIEILHQFTKPMPVLT-RE---------GYCINETH------- AqueK490_Aque -------WEEDPTLRPSALDLLHLLSEPQFQCH-LS---------TQTLRDCV------- AqueK491_Aque -------SSQVPDDGSTSETSLT--------------------------PSVS------- AqueK492_Aque -------WKDKADDRPETSELISD------------------------------------ AqueK493_Aque -------WKDKADDRPETSELISDVSKVTFQSI-MG---------VLPVRSR-------- AqueK494_Aque -------LQYVPNNRPRAQDIFDRMCMPDFMAL-RH---------VVPIHED-------- AqueK495_Aque -------LSIDPIKRPTAEGVASRLVICVGPYT-QE---------KYVLDQN-------- AqueK496_Aque -------WSKDPSARPKMKECLQWTSTAEFERL-RA---------QLTLGSC-------- AqueK497_Aque -------WRHLAADRPTADEVVQRISAPGFLCR-RH---------TVSRVQQ-------- AqueK498_Aque -------WQQSEELRPTASQITKVSQMDQFLRL-AD---------AIRVNNF-------- LRRK2_Hsap --------------------------------------------------V--------I LRRK1_Hsap --------------------------------------------------T--------A CG5483_Dmel --------------------------------------------------E--------K LRRK2_Mmus --------------------------------------------------I--------I LRRK1_Mmus --------------------------------------------------S--------A T27C10.5_Cele --------------------------------------------------L--------P GbpC_Ddis -----------------------------------------------------------S Pats1_Ddis QQQQQQQQQQSSPSKS--------SSTSP--------------------IIKSLN---LS QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis -------------A-----------------------------------SDN-------N Roco11_Ddis ------------PE-----------------------------------------QKS-- Roco4_Ddis ------------TSS----------------------------------TTNNLNSANVS Roco5_Ddis -------------S-----------------------------------AKS-------T Roco6_Ddis -----------------------------------------------------------S Roco7_Ddis QINQQQQ--QPPP-QSQAAQQQQPSTSTPPLSQHQQKLSISNLQLNNLLNNHNSNGSNSS Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis TS----------------------KN--------------------------------QH LRRKd_Spur --------------------------------------------------E--------G LRRKc_Spur --------------------------------------------------E--------G LRRKb_Spur --------------------------------------------------V--------N LRRKa_Spur --------------------------------------------------P--------V AqueK485_Aque --------------------------------------------------W--------S AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------DTFQI-SSD-----------------------------------S--------N AqueK489_Aque -EYN-ASAVRYN-RESNGTFSC-------------------------------------- AqueK490_Aque -----------------------------------------------------------S AqueK491_Aque -QYH-TNVVRG-------DLQE-------------------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque --------------------------------------------------F--------S AqueK494_Aque --------------------------------------------------W--------E AqueK495_Aque --------------------------------------------------W--------H AqueK496_Aque --------------------------------------------------T--------A AqueK497_Aque --------------------------------------------------H--------P AqueK498_Aque --------------------------------------------------GS-------Q LRRK2_Hsap VECMVAT---------HHN------------SRN-------------------------- LRRK1_Hsap F---FS-------------------------------SQ--------------------- CG5483_Dmel IVCGVFQ---------SLV-------------------G--------------------- LRRK2_Mmus VECMVAT---------NLN------------SKS-------------------------- LRRK1_Mmus F---FS-------------------------------SQ--------------------- T27C10.5_Cele PTQLMAV---------GIT------------------DE--------------------- GbpC_Ddis SISEAML---------PS-------------NLLHLNLNGINNNNNNSNNNNNSIPVTTI Pats1_Ddis --TVSEL---------GE-------------SS--------------------------- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis IYSDHPL----------P-------------SGGSI------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis IASTSSN---------AD-------------DGSQT--NNNNNNNNNNNNNNNNNSGSSI Roco5_Ddis ISTGFNS----------N-------------SGATT------------------------ Roco6_Ddis VVSGIQS---------PN-------------SLADSQPFHYHQQ-------------QQP Roco7_Ddis IQSSLS----------HN-------------NNNLN--NNINNNNNNNNNNNNNSSGGSS Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis IQ---------------------------------------------------------- LRRKd_Spur VSLAFS-------------------------------QG--------------------- LRRKc_Spur VSLAFS-------------------------------QG--------------------- LRRKb_Spur VECQAVR---------TY--------------------Q--------------------- LRRKa_Spur VSCAVAT---------TAG------------C------S--------------------- AqueK485_Aque PLKL-TL---------DME------------------VL--------------------- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque VTHACIV---------PPS------------P------L--------------------- AqueK489_Aque ------------------------------------DL---------------------- AqueK490_Aque VRGCCYV---------P--------------SLS--QVWA-------------------- AqueK491_Aque ------------------------------------EV---------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque LKCGCAI---------TPH------------DYV---K---------------------- AqueK494_Aque VLAFTVR---------NY--------------------H--------------------- AqueK495_Aque IQEAVFL-----------P------------EKGEILAWE-------------------- AqueK496_Aque ISCACVS---------RIE------------PKYE-SEWI-------------------- AqueK497_Aque LQKIDTI---------YC--------------------Q--------------------- AqueK498_Aque VAGSCYRILKSPVFKPSLTPHTPGHHSFPFVPSLK-SQGA-------------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ---------------------G-------------------------------------- CG5483_Dmel ----------M----------G-------------------------------------- LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ---------------------S-------------------------------------- T27C10.5_Cele ----------I----------D-------------------------------------- GbpC_Ddis SLTSSGTSPTN---------SPVGGLLSQSLTQP-------------------------- Pats1_Ddis ----N-QTP-----------KQNITTTTTTTHSD-------------------------- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ----I-Y-------------QDKIIH---------------------------------- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ALSPS-RSF-----------EQQTTTTTTTTTSP-------------------------- Roco5_Ddis ----T-TKP-----------KSSTIS---------------------------------- Roco6_Ddis SLNST-----N---------QLQQQQYSSVLTSP-------------------------- Roco7_Ddis GVSHS-GSS-----------G--------------------------------------- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis -L---------------------------------------------------------- LRRKd_Spur ---------------------S-------------------------------------- LRRKc_Spur ---------------------A-------------------------------------- LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur --------PEGDG--------P-------------------------------------- AqueK485_Aque ----------L----------T-------------------------------------- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque --------PPPPS--------P-------------------------------------- AqueK489_Aque YIC-------S---------SVLSMK---------------------------------- AqueK490_Aque ----------Y---------GEYNVN---------------------------------- AqueK491_Aque WFC-------S---------KEKDDQ---TLER--------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque --------PKG----------N-------------------------------------- AqueK495_Aque ------------RDGQRR------------------------------------------ AqueK496_Aque -------EPADTVKSENSLPTVMNGTL--LT---REEIERFGLDVDILLASQDCLEIEES AqueK497_Aque --------PVINE--------S-------------------------------------- AqueK498_Aque -------SPLRTSIKASSIPTNETGSRAAVSNQPQSKIDSNPNQVDI------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ----------------ITSGGSTSGILSTS------------------------------ Pats1_Ddis ----------------H----------KRQLS---------------------------- QkgA_Ddis --------------------------------Y--------------------------- QkgA_C2d_Ddis --------------------------------Y--------------------------- Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ----------------S----------SPSTSF--------------------------- Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ----------------R----------SNL------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ----------------D----------STVLTH--------------------------- AqueK490_Aque ------------------------------IG---------------------------- AqueK491_Aque ----------------A----------SSRLSF--------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------VVSINEETFSTEL----------------- AqueK496_Aque IIKTKEVVVSDDPGSDE----------ERGLENLSTEEKKKETE-DDRVMKKSDKLAS-- AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque --NPKEEGLLSKACNES----------GHNLMFNSTEKQLLEAAAEIRANETSLPLTEAQ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ----------------------------------------------------------DD LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ----------------------------------------------------------DP GbpC_Ddis ----------------------------------------------------------VN Pats1_Ddis ----------------------------------------------------------TD QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ----------------------------------------------------------FG Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ----------------------------------------------------------IN Roco5_Ddis ----------------------------------------------------------SG Roco6_Ddis ----------------------------------------------------------SD Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis -----------------------------------------------------------N LRRKd_Spur ----------------------------------------------------------QD LRRKc_Spur ----------------------------------------------------------QD LRRKb_Spur ----------------------------------------------------------KD LRRKa_Spur ----------------------------------------------------------DA AqueK485_Aque ----------------------------------------------------------SP AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ----------------------------------------------------------NT AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ----------------------------------------------------------RD AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ----------------------------------------------------------AN AqueK494_Aque ----------------------------------------------------------KK AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ---------------SSSL-VETKALTK----------------ELLGKEDKAKRHGEEQ AqueK497_Aque ----------------------------------------------------------VC AqueK498_Aque NVIEDLVSPMSTSSASSSVHFKPQAYVTEEGESKHRIPPSLQILPDIGEGEEREREGEED LRRK2_Hsap ----AS----IWLGCGH--TDRGQLSFL-D---LNT-E---------------------- LRRK1_Hsap QEYTVV----F-WD-GK--EESRNY--T-V---VNT-E---------------------- CG5483_Dmel ERCGLE----LWLPSFG--SR---I--D-I---LDC-S---------------------- LRRK2_Mmus ----AT----LWLGCGN--TEKGQLSLF-D---LNT-E---------------------- LRRK1_Mmus QEYTVV----F-WD-GK--EESRNY--T-V---VNT-E---------------------- T27C10.5_Cele DDFEAQ----LWLSG----RE---M--V-V---MGC-T---------------------- GbpC_Ddis RDNS------------------SL---V-SAS--SLGNNTSTSSLASLVSNNSGLHHSPS Pats1_Ddis SGSSYRNKSHDTISH-------STS----------------------------------- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis -GWNNSSKPH------------SKV--F-A---LNL-S---------------------- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis SSGSYNTESY-SVAS-------S------------------------------------- Roco5_Ddis SGTTSPPQPH------------PQL--V-RKLTQNF-T---------------------- Roco6_Ddis SSNS------------------SQN--I-ANK--SL-NNISATSLGDL------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis R---------------------GNT----------------------------------- LRRKd_Spur EDKVVH----LIVESGR--GTSVRS--F-Q---VD--E---------------------- LRRKc_Spur EDKVVH----LVVDSGR--GTSVKS--F-Q---VD--E---------------------- LRRKb_Spur DQERTE----IWLAGGE--KNSTMF--S-C---FTI-R---------------------- LRRKa_Spur SSSLPV----IWMTQTVEEDQSSSV--V-I---LNI-D---------------------- AqueK485_Aque -SSPYV----YWASG-S--RG---L--V-I---GNI-E---------------------- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ---------------PVETDPEASI--AST---VSS------------------------ AqueK489_Aque ----------LSIPG---------F--K-T---L-------------------------- AqueK490_Aque TGEGSE----LLVEG-------TQV--F-I---LNA-T---------------------- AqueK491_Aque ----------VSFRG-------RAN--F-V---V-------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ITGHTN----TWDT-----QNEE--HLY-N---IDV-R---------------------- AqueK494_Aque HGVRTE----VWLTSCD-AGQQSML--S-V---INL------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque AY--SQ----IWMCGRD--QKKGLL--S-V---FIF-P---------------------- AqueK497_Aque ENTQYL----LWTWSRQ--DTERNF--S-L---FNV------------------------ AqueK498_Aque NHRFYQ----VWVVSSS--NHNSVA--T-V---VDY-C---------------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------PSGSLLQ-CNSI LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------QYGFV-D-QKS- GbpC_Ddis ASDGLNDYYGADNNNNNNDSTMDFFQDIFTEEENEQPYPFADDDQQK---G-ILFGF--D Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------GGNDENLGGQLQY-S--M Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque -----------------------------------------------PDEGTLY--SKIL AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ---------------GYT--SE--EV---------------------------------- LRRK1_Hsap ---------------KGL--ME---V---------------------------------- CG5483_Dmel SCSPQPQVAPPKTPENGA--NSRARS---------------------------------- LRRK2_Mmus ---------------RYS--YE--EV---------------------------------- LRRK1_Mmus ---------------KGL--LE---V---------------------------------- T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis -EE-----------QT-------NPSASS------------------------------- Pats1_Ddis -----------------------------VASDLLDIDN-----TLTVATTPRN-----R QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ---------------S-------MLFEDKLMVVLNNKQSTTYKA-----FYTHM-----Q Roco11_Ddis ---------------------------------------------IN------------- Roco4_Ddis -----------------------------STTNLL---N-----TLNNANQPVNFIGTAS Roco5_Ddis ---------------P-------IATSPTPSVIVSSVPTTTTTTTTSVATTPTV-----Q Roco6_Ddis -RV------------P-------QPEAKV------------------------------- Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------IYTLV------------------------- LRRKd_Spur ---------------DGC--YKSSLL---------------------------------- LRRKc_Spur ---------------DGC--YKSSRL---------------------------------- LRRKb_Spur ---------------NS---EQDASV---------------------------------- LRRKa_Spur ---------------RTP--SDDTTC---------------------------------- AqueK485_Aque AEAPRPE--------SGLFANRRGKP---------------------------------- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque -----------------P--TSSV------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ---------------N-------LTVQ--------------------------------- AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ---------------EVL--MKQIGI---------------------------------- AqueK494_Aque ----------------T---DKAAQP---------------------------------- AqueK495_Aque -----------------------LM----------------------------------- AqueK496_Aque ---------------DRQ--KTSSR----------------------------------- AqueK497_Aque ----------------A---KGMFTL---------------------------------- AqueK498_Aque ---------------GQF--MK---I---------------------------------- LRRK2_Hsap -----------------------------A------------------------------ LRRK1_Hsap -----------------------QRMC-CP------------------------------ CG5483_Dmel ------------------------AQR-LP------------------------------ LRRK2_Mmus -----------------------------A------------------------------ LRRK1_Mmus -----------------------QRMT-CP------------------------------ T27C10.5_Cele -------------------------IE-LP------------------------------ GbpC_Ddis -----VSI--------IIAATMAKMIE-MMTKGESSATLKSEHISTRRRSDTAGKNGVPP Pats1_Ddis SKTNDDNIIN-------------------------------------------------- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis SE---------------------------------------------------------- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis VHKKMEVLAGVEAGETVW------------------------------------------ Roco5_Ddis TI---------------------------------------------------------- Roco6_Ddis -----NQL--------V------------------------------------------- Roco7_Ddis NNFVIPIITAIANGGI-------------------------------------------- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur -----------------------NELQ-CP------------------------------ LRRKc_Spur -----------------------NELQ-CP------------------------------ LRRKb_Spur -----------------------QGMI-IQ------------------------------ LRRKa_Spur -----------------------FNLT-VT------------------------------ AqueK485_Aque -----------------------IPIA-VG------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------NSS-YM------------------------------ AqueK489_Aque -----------------------NNTS-LP------------------------------ AqueK490_Aque -----------------------GSLE-LK------------------------------ AqueK491_Aque -----------------------DSID-LE------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque -----------------------GDKS-AY------------------------------ AqueK494_Aque -----------------------QGRMLPQ------------------------------ AqueK495_Aque -----------------------RPTT-II------------------------------ AqueK496_Aque -----------------------FFGY-IG------------------------------ AqueK497_Aque -----------------------P-EKPSA------------------------------ AqueK498_Aque -----------------------EDVD-LG------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis HWRNSVPLSTNSSTTLDETFIDDFIYVYRSFTTPRNIFKLLVRRFFGPRHTDKVDTFTIK Pats1_Ddis -------------------TSNGRIITN-------------------------------- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis -------------------FNEENLMFY-------------------------------- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis -----------------TKSADSSLCFW-------------------------------- Roco5_Ddis -------------------LAGGNITPK-------------------------------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------GS---------------------------------------- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis KFEQKKAAIRQGIAVFLRKWVADITELEFRQEEFWLYHNTVAFTKQFIASEFPTIATQIY Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ----------------------------------W------------------------- Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis GTLTTHEDEVNLTNQRFLQIAFSESEIQIDR-AMS---------------SMQ------- Pats1_Ddis ------------------------------S-INNSNSNNEQPL--SPNSLLQHSQSQQQ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------EAIK--------TFKSLP------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------S-TKKGHL---------------------- Roco5_Ddis ------------------------------PSVP--------T-AMKP------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ----------------------------------------KRPI--T------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis -------------LTTPKPFRSQKNLANSYNSQSGGGDSSFYYQP--------------- Pats1_Ddis LENVGLSALLDALPNSPIVSSTA--------------------APSTTSTNKKVMYTSIV QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis --------------------------------------------E--------------- Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap --------------------------D-SRILCLALV----------------------- LRRK1_Hsap --------------------------G-MKVSCQL------------------------- CG5483_Dmel --------------------------K-MNMLCCC------------------------- LRRK2_Mmus --------------------------D-SRILCLALV----------------------- LRRK1_Mmus --------------------------G-MKLSCQL------------------------- T27C10.5_Cele --------------------------H-R-GKYVS------------------------- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis GDSARTRRGSVSIQPFQNEFNRELLPNQGTIQCLI------------------------- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ----------------------NQTPDD-------------------------------- Roco11_Ddis ----------------------DKSP---------------------------------- Roco4_Ddis -------------------INELKCPHTVATTMMI------------------------- Roco5_Ddis ----------------------NITPKP-------------------------------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------GGNQHQQNGS-------STPHS------N------------------------- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur --------------------------M-IRTAIAT------------------------- LRRKc_Spur --------------------------M-IKTAIAT------------------------- LRRKb_Spur --------------------------K-GRA----------------------------- LRRKa_Spur --------------------------G-GTVRCVC------------------------- AqueK485_Aque --------------------------H-ATAIDVC------------------------- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque --------------------------S-PLLVCLA-LRQEESS----------------- AqueK489_Aque --------------------------A-QCIVCMA------------------------- AqueK490_Aque ----------------------------ERANAIC------------------------- AqueK491_Aque --------------------------C-APVTAMC------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque --------------------------D-AIMTCM-------------------------- AqueK494_Aque --------------------------N-TLV----------------------------- AqueK495_Aque --------------------------T-ETCLHMA------------------------- AqueK496_Aque --------------------------K-EEIQALC------------------------- AqueK497_Aque --------------------------G-GRV-----------FAMATTGEVDIFSFGMLL AqueK498_Aque --------------------------D-SPVLAIS------------------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque FELITGQRPFESMSTGQEVNRAVIQRERPQVSEGNMEPSFPGMIELMEDCWRHLAADRPT AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap -------------------------------------H---------------------- LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus -------------------------------------H---------------------- LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur -----------------------------------LCM---------------------- LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ---VVVMCEAVGSYDSNKVVM-KMTPMLQKIQEPIVSL---------------------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque -----------------------------------YCM---------------------- AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ADEVVQRISAPGFLCRRHTVSRVQQHPLQKI-DTIYCQPVINESVCENTQYLLWTWSRQD AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ---------------------------------L-PVEKESWIVSGTQSGT------LLV LRRK1_Hsap -----------------------------------QVQRS--LWTATEDQK------IYI CG5483_Dmel -----------------------------------LVGEA--IWMGDVSGN------LHA LRRK2_Mmus ---------------------------------L-AAEKESWVVCGTQSGA------LLV LRRK1_Mmus -----------------------------------KVQSS--VWIATEDQK------IYI T27C10.5_Cele -----------------------------------KVRDS--VWSCDECGQ------VTV GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis --------------------------------KVGGNGCQ--VWAGTGNGF------IST QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis -----------------------------------KVGKY--IWEATNSNG------IYI Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis --------------------------------SQSNSGSS--SVYESGDGS------LS- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur -----------------------------------PCGTK--IVVGTGGDC------VQL LRRKc_Spur -----------------------------------PCGTK--IVVGTVGDF------VQV LRRKb_Spur ---------------------------------V-AIGPNT-MLVGTQSCE------LVL LRRKa_Spur -----------------------------------SVADT--MWLGLNTGS------IVV AqueK485_Aque -----------------------------------TYTRQ--VWVGTENGL---MGSVYV AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ---------------------------------FSLPDRS--VFVGRSGSS------ILY AqueK489_Aque -----------------------------------CTREY--LWVSFQHNF------VRV AqueK490_Aque -----------------------------------TVDSK--VWVGMLEAC------IHV AqueK491_Aque -----------------------------------CVNEQ--VWLGAKDGC------ITL AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ---------------------------------T-PALDV--VWVGMATGH------ILL AqueK494_Aque -----------------------------------LIVDQDWILMGTNTGH------VIV AqueK495_Aque -----------------------------------IVWNK--LFLVTSSKR------VYC AqueK496_Aque -----------------------------------PVRNA--MWVGTSLGN------LRV AqueK497_Aque TERNFSLFNVAKGMFTLPEKPSAGGRVFAMATTG-EVERRLW--VATSVARNFPDFEIQV AqueK498_Aque -----------------------------------MVHDK--VWIGFEIGY------LCI LRRK2_Hsap INTED-GK-KR--------------HTLEKMTD---SVTC-----------LYCNSF--- LRRK1_Hsap YTLKG-MC-PL------N-----TPQQALDTPA---VVTC-----------FL--AV--- CG5483_Dmel YSTST-YA-HL------F-----SYMLDPNIKS---AVIS-----------LV--YM--- LRRK2_Mmus INVEE-ET-KR--------------HTLEKMTD---SVTC-----------LHCNSL--- LRRK1_Mmus YSLKG-MC-PL------S-----VPQQALDTPA---VVTC-----------FL--AV--- T27C10.5_Cele YGISL-HE---------T-----GHLQLPSLNG---TLIC-----------AP--EL--- GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis WKIEGQEK-Y--------IQRL----FEANKDK---K---RIH--------C--LY---- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis --------------------------------R---E---IIK----------------- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis WDMGT-MT-I--------VQQL----TTPHKGD---V---CLH--------FV-EY---- Roco5_Ddis --------------------------------T---L---I------------------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis SAG--SFKIL------RY--EM----VLPVAFT---S---TIH--------S--LYP--- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ---------PIQQQQQQKQ----------------------------------------- LRRKd_Spur YHLPS-SH-SS------HA-SLLVEARVAGQPT---SL-H-----------YI--QK--- LRRKc_Spur YHLPS-SQ-SS------HA-SLLVEARVAGQPT---SL-L-----------YL--QK--- LRRKb_Spur INLTS-SP-------------YQVKHTLPQLPD---AVLC-----------LS--WH--- LRRKa_Spur YENGR-FS-YP---------NEIARLSLPQYKSKPRSPCT-----------ML--HI--- AqueK485_Aque FNLPD-FK-SH-------------H--YIHLQD---AVLS-----------LK--IMNST AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque IHGNE-PP-L------------------------PLTICE--RCQNGKVMFIR--YF--- AqueK489_Aque YSASS-LE-FI--------KEL----TF---DA---H---VLV--------MA------- AqueK490_Aque YDSTS-FN-F--------TDRV----FV---KD---S---V-----------T------- AqueK491_Aque YSAIN-HD-KS------FSRYL----SL-KADQ---G---IIH--------IS--HL--- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque FHEQE-LI-MH------F-------HPYTQYLR---FLIV-----------VPCE----- AqueK494_Aque SEGNG-ST-EGG-----GTERNRKEHKLAKLED---SVLC-----------FC--YV--- AqueK495_Aque YSLPD-FT-LL------S-----SSKE--PLPA---QSSC-----------LF--VS--- AqueK496_Aque IHAPS-LA-VK------F-----SGNL--SSDD---QSSAILK--------IL--HI--- AqueK497_Aque FSYKN-A-----------VEPPVYLW-SFIVRD---SVLD-----------MT--TV--- AqueK498_Aque YDADT-HN-TL------A--QVW-----IRRGI---AVQ----------------SI--- LRRK2_Hsap ------SKQSKQKNFLLVGTAD-G----KLAIFEDKTVKL----KGA-----AP-LKI-- LRRK1_Hsap ------PVIKKNSYLVLAGLAD-G----LVAVFPVVRGTP----KDS------------- CG5483_Dmel ---------E-KIARVAVGTHN-G----RVFLVDATQMPS----NC------AFAEG--- LRRK2_Mmus ------AKQSKQSNFLLVGTAD-G----NLMIFEDKAVKC----KGA-----AP-LKT-- LRRK1_Mmus ------PVIKKNSFLVLAGLAD-G----LVAVFPVARGTP----KES------------- T27C10.5_Cele ---------ISNDVLIL--ISD-K----QIVLLKLSESN----------------SV--- GbpC_Ddis ------S--SNDVSRVFLNLAT-GMRDPLLGITVKEKK---FKK---------------- Pats1_Ddis ----------PYMNTVWCGSAD-D----SITIWDIDTY---QK-IKS-----YSV----- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis -------IQSKKIYQVFIGENA-PK---EINLPFLLKK---EL-KNK-----IDF----- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ----------GDNNGVWSGGSE-G----TVCLWDMQTF---EK-KHS-----FS------ Roco5_Ddis ------------------SSQKPPA---PNPVPILK-T---PT-PTNLSPTSIST----- Roco6_Ddis ------V----NSRRVWGGCES-G----EIIVWNAENG---NQIFRE-----QKL----- Roco7_Ddis ------VQNNKNEVFVWCGMGD-G----SVCVINSATR---QI-VST-----SRI----- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------PSGQ-EHSLLFVGQAN-G----VLTVLSHETEDS----GHH-----ITDDLKLV LRRKc_Spur ------PSGQ-ERSLLFVGQAN-G----ALTILSHETEDS----GHH-----TTDDLRLV LRRKb_Spur -------TKRREDGKVFAGLAN-G----TIAVYSAKRIRL----EKD-----CKPDQY-- LRRKa_Spur ----------PPLQLVAIA-AD-H----EVAFRQEDGNGM----PSA-----D-SDGF-- AqueK485_Aque PPPPPSSSQSEYDYKALVGLAN-G----TIIIFSGRNQER----LLE-----NPLQG--P AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ----------QKDQIFVCGFSN-G----AVHTSHTSQRDM----KKP-----D-SLIG-- AqueK489_Aque ----------VSPDCVYLGKED-G----EIQVFNLSQP---SPLHGA-----Y-R----- AqueK490_Aque -------DIATNDKYAFVGLAN-G----TLTYYDKLKF---PS-VSG-----D------- AqueK491_Aque ----------TKLRQVLVVRKD-G----YLMLLDEVLSERRIPDTSH-----F-D----- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------GPCEKEK-CMMASGAK-G----F-----------------Q-----SP-LEG-- AqueK494_Aque ------KRRYEGKSYVFMGLAN-G----HLVAFDSQSIKT----PNA-----S-PEVD-- AqueK495_Aque ------CDA-SMVAVGMEGGAG-G----RIALFTASSEEG----GAS-----ALATPPL- AqueK496_Aque ------EEK-NCILVSST---C-S----EVWCL----------------------HDKL- AqueK497_Aque ------V-EGGRVKRVFASLAN-G----TICVFSRVSISS----PQP-----S-EVGD-- AqueK498_Aque ------AHIP-QLSQVYVGLAN-G----TILSYSDIITPI----SND-----DDS----- LRRK2_Hsap --LNIG------------------------------------------------------ LRRK1_Hsap -------------------CSY-------------------------------------- CG5483_Dmel SFV-LT------------------------------------------------------ LRRK2_Mmus --LHIG------------------------------------------------------ LRRK1_Mmus -------------------CSY-------------------------------------- T27C10.5_Cele SH--LG------------------------------------------------------ GbpC_Ddis ---------------DK--VSTLCCSG-SEIIDWITKCMPIKREEASILVLDMLMKQFFI Pats1_Ddis -------------EG-PSC----------------------------------------- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------PDG-PS------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis --PTTP-TTPTTPTT-PT------------------------------------------ Roco6_Ddis -------------HPGP--IRSLALVNQEDI--WS------------------------- Roco7_Ddis -------------AD-SSRILGFSLIRK-------------------------------- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur TRMQLS-K-----HNL--PCSS-------------------------------------- LRRKc_Spur TRMQLS-K-----HNL--PCSS-------------------------------------- LRRKb_Spur --IQVG-T-----Y---------------------------------------------- LRRKa_Spur --HYVHVQ-----R---------------------------------------------- AqueK485_Aque RRV-VT------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque --SYCGES-----K---------------------------------------------- AqueK489_Aque --TRVI-S-----YQK--PIKSL------------------------------------- AqueK490_Aque --IEIG--------SK--ALISM------------------------------------- AqueK491_Aque --AHVN-A-----TQL--PVRCV------------------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque --YPLD------------------------------------------------------ AqueK494_Aque --ILLN------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque --AQVI-P-----E----ACVL-------------------------------------- AqueK498_Aque -------------------VPL-------------------------------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis QISDDGIPISNQKGTNPTFSDSPTSFYMFLEDDPELIARQYTFLELKYLQNIHPRELL-- Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ---------------------------------------------------------AGG Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis -GFSVGLVMPNENEKDPEKWRQSNFPHIYDYFRWFNKMTMLVSTEILRQRDIKQRASIIE Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis IGPQQS------------------------------------------------------ Roco7_Ddis CTPSS--------------------------------------SSVTL------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis KYISIALEYLSLWN-----------------------------------------FNGIM Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis --------TIRIWNAWRFNLDDQSGTKSDFITKKGRGGSTFGRKSWRLRWFVLSRFDKTL Roco7_Ddis ------------TSRSSLN------------------LSSLASGSTPSPY-SSGGSGGSL Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap --------------------------------------NVSTPL---------------- LRRK1_Hsap --------------------------------------------LCSHTANRSKFSIA-- CG5483_Dmel --------------------------------------EICSGF---------------- LRRK2_Mmus --------------------------------------DVSTPL---------------- LRRK1_Mmus --------------------------------------------LCSHTANRSKFCIP-- T27C10.5_Cele --------------------------------------TIDSPY---------------- GbpC_Ddis QVLSSLHSEPISRLSATWAKVSQRSMDCFYE----------------------------- Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis KYYSK--------------QTDKE-PSCSLILEGAWLEEISPPG---------------- Roco7_Ddis G-------------------SSYQ-PICPTI----------------------------- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur --------------------------------------------IVAVSRKKNGDSMAEQ LRRKc_Spur --------------------------------------------IVAVYRKKNGDSVAER LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------EI---------------- AqueK485_Aque ------------------------------------------TF---------------- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------SIK--------------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque -------------------------------------FNLKTPL---------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque --------------------------------------DFPQTE---------------- AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque --------------------------KCEDDKYRTEAEDWGQPLI--------------- AqueK498_Aque --------------------------------------------IATHLTPLSTYKEP-- LRRK2_Hsap ------------------------------------------MCL--------------- LRRK1_Hsap ------------------------DEDAR-QN------PYPVKAM--------------- CG5483_Dmel -----------------------------VL-------HAACSV---------------- LRRK2_Mmus ------------------------------------------MCL--------------- LRRK1_Mmus ------------------------DEDAR-QN------PYPVKAM--------------- T27C10.5_Cele -----------------------------EI--------RTATF---------------- GbpC_Ddis ---------------------------------------------LSRLMLPESNYLPLR Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------YKVSLHLIHPEK------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur RRRYEEVVYNGANGVWNRSAKSNGTREER-RD------ETTARKM--------------- LRRKc_Spur RRQYEDVVSNGANGSRDRSVQSNGT------D------ETTARKM--------------- LRRKb_Spur --------------------------------------HEPIKCS--------------- LRRKa_Spur ------------------------------IS-------MAIVLK--------------- AqueK485_Aque -----------------------------N--------RKPCLG---------------- AqueK486_Aque --------------------------------------------R--------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------GA-------TAYQII--------------- AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------SSV--------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------EDR--------------- AqueK494_Aque --------------------------------------RGPIKGM--------------- AqueK495_Aque -----------------------------IMK------PFDHLNK--------------- AqueK496_Aque -----------------------------IGK------PYSIVKE--------------- AqueK497_Aque ------------------------------LTLSEAAKGMSIKYM--------------- AqueK498_Aque ------------------------NEICPVIL------PIMVKPW--------------- LRRK2_Hsap -----------------------------------------S-----------------E LRRK1_Hsap -----------------------------------------E------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus -----------------------------------------S-----------------E LRRK1_Mmus -----------------------------------------E------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis TALASQKPNTIIQASPLYPNISAYMVHTVCPTIPFLGALIAD-----------------L Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis -------------------------------------RTMEM-----------------E Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur -----------------------------------------R-------GGRNSLEPRER LRRKc_Spur -----------------------------------------R-------KGRNTLVTRER LRRKb_Spur -----------------------------------------Y------------------ LRRKa_Spur -----------------------------------------K------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque -----------------------------------------Y------------------ AqueK489_Aque -----------------------------------------Q-----------------V AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque -----------------------------------------L-----------------T AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque -----------------------------------------S-----------------Q AqueK494_Aque -----------------------------------------K------------------ AqueK495_Aque -----------------------------------------RRG----Q----------- AqueK496_Aque -----------------------------------------QRIQTNEREGSG------- AqueK497_Aque -----------------------------------------T------------------ AqueK498_Aque ----------------------------------------------------------NE LRRK2_Hsap S---TN----STERNVMWGGC-GTK----------------IFSF--S-NDF-TI-Q-KL LRRK1_Hsap -----V----VNSGSEVWYSN-GPG----------------LLVI--DCASL-EI-CR-R CG5483_Dmel ----VV-----DGIYELWCGE-IAGK---------------INVF--PLNEN-GVSGHQA LRRK2_Mmus S---LN----SSERHITWGGC-GTK----------------VFSF--S-NDF-TI-Q-KL LRRK1_Mmus -----V----VNSGSEVWYSN-GPG----------------LLVI--DCTIL-DI-SR-R T27C10.5_Cele ----LG----NGSTRQIWAGH-SEGR---------------ISIH--HIASNDSFSFSSS GbpC_Ddis S---Q-----TCTENPTFISSGGEKMINI---------------LRV--KRL-SK--K-M Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ----------------------------------------------VTVFN--------- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ----------------------------------------------TPT----------- Roco6_Ddis F---K-----SESEKSSWLTA-INRVIN----------------QNIPLYEI-AL-GK-Q Roco7_Ddis -----------EEDSHIWAFY-NE---------------------GILCFEA-KS-FK-L Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur TGGSRD----EADGTEVWVGC-GNK----------------LRII--LLDDI-TL-EPDG LRRKc_Spur TGSSGD----EADGTEVWVGC-GNK----------------LRII--SLSDI-TL-EPDE LRRKb_Spur -----L------TNSRLWVGV-GDRV----------------EAI--TLKTL-KS-EI-K LRRKa_Spur ----NG----SKRSYELWCGQ-TEGYI---------------TVL--DAGNL-TL-CQ-V AqueK485_Aque ----IN----AGTDGHLWTAC-GDN----------------FEVF--EFPAM-K-SVRRN AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque -----R----EGENFEVWCGS-KDSFI---------------EVSTFNVTNV-KA-RR-V AqueK489_Aque L------------DDCIICCT-KNSFYR------------------VHPNTL-HV-LQ-E AqueK490_Aque ----------LSVGECLWVVC-GNEIIV----------------LCVDDDDI-TI-AK-R AqueK491_Aque L---SS----NEETAYTWISS-SNEVVTV---------------LEIRTSVI-SH-CQ-K AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque S---LD----DSGVMILWEAYSGAT----------------L-----------RQ-M-KI AqueK494_Aque -----R----L--HDRLYVIS-ELQV----------------FVI--SLKEL-KV-LF-K AqueK495_Aque -VSSGC----FCGDSKILCGS-GR----------------YLFGL--SLPKM-KQ-VF-- AqueK496_Aque -PVYDLVKVVIDGQLQVWGTM-DNNTIILFEKKEGAWQTSYYDVI--PYSHH-MK-V--- AqueK497_Aque -----F----V-GKDFLWCGC-GNSI----------------SVI--NVVEM-KV-VT-S AqueK498_Aque EEGREE----EGIAFHLWVGQ-KNKS---------------ITVL--NAEDL-SI-VD-F LRRK2_Hsap IET------------------R----------TS-----QLFSYAA-FSDS-NIIT---- LRRK1_Hsap LEPYM-------------------------------------------A-P-SMVT---- CG5483_Dmel LCH------------------------------------------S--EEP-NLIE---- LRRK2_Mmus IET------------------K----------TN-----QLFSYAA-FSDS-NIIA---- LRRK1_Mmus LEPYA-------------------------------------------A-P-SMVT---- T27C10.5_Cele LYL------------------------------------------P--DDK-CIVR---- GbpC_Ddis KMF--------------------------------------------KEYK-EMPTQYLP Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis MTS--------------------------------------------GSEN-DYIT---- Roco7_Ddis LK---------------------------------------------TIKT-NFIT---- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur IQVAA-------------------------------------------GME-GIIE---- LRRKc_Spur IQVAA-------------------------------------------GVE-GIVE---- LRRKb_Spur LE------------------HD----------K------K---ETSKDPRK-LGLV---- LRRKa_Spur ILC-----------------HL----------E------D---PLPLAPVT-QMVT---- AqueK485_Aque VCS------------------Y----------SNG---GG---G-A--SAS-SVKG---- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque QSL-----------------SL----------K------H---KT-FTVPS-SLVS---- AqueK489_Aque F--L-------LIS-------------------------------E-TGV----KS---- AqueK490_Aque LNAA-------------------------------------------SSNH-QVYA---- AqueK491_Aque LQAR-------SYS-------------------------------E-TNKT-DILS---- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque IEK------------------ESPGYLDNHKTVA-----RMIKKLQ-FKDDTHIVK---- AqueK494_Aque W--------------------------------------V---ACE-DSSR-KFLT---- AqueK495_Aque ------------------VHTL----------SDRGGEKG---GAK-GDEE-SVIE---- AqueK496_Aque -----------------------------------CSHIV---WCS--------FE---- AqueK497_Aque I--------------------------------------P---VFT-R-RA-QLIN---- AqueK498_Aque LDTPDDTTPCPSYLDQVPFYYL----------TSS---VS-------PKDS-EDSE---- LRRK2_Hsap --------------V--------V-VD--------------------------------- LRRK1_Hsap --------------SVVCSS-EGR-GE--------------------------------- CG5483_Dmel --------------DVKVAR-MCS-NE--------------------------------- LRRK2_Mmus --------------L--------A-VD--------------------------------- LRRK1_Mmus --------------SLVCSS-DCR-GE--------------------------------- T27C10.5_Cele --------------QLV----GSK-DA--------------------------------- GbpC_Ddis ALTTIPLQYYEHYVN-----D-LK-ALDSLQIDRLSDIERKLEIICEKNGTTNDDKEKGD Pats1_Ddis --------------------I-TR-VG--------------------------------- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis -----------------------D-TL--------------------------------- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis --------------N-----L-LS-VG--------------------------------- Roco7_Ddis --------------S-----L-VD-EG--------------------------------- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur --------------GIV------Q-SQ--------------------------------- LRRKc_Spur --------------GIV------H-SQ--------------------------------- LRRKb_Spur --------------K-T-----VA-LE--------------------------------- LRRKa_Spur --------------YDLAIQ-EQM-GL--------------------------------- AqueK485_Aque --------------EV-IIY-SGL-NR--------------------------------- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque --------------WM-CLT-SD---E--------------------------------- AqueK489_Aque --------------AVVALD-RMN-NN--------------------------------- AqueK490_Aque --------------L-----VLSE-RN--------------------------------- AqueK491_Aque --------------HMTCVKLGGRDER--------------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque --------------D--------L-TA--------------------------------- AqueK494_Aque --------------C-I-----EA-ND--------------------------------- AqueK495_Aque --------------GM------VL-YG--------------------------------- AqueK496_Aque --------------EE------GT-QC--------------------------------- AqueK497_Aque --------------E-L-----VS-DG--------------------------------- AqueK498_Aque --------------SILLRE-DAL-EP--------------------------------- LRRK2_Hsap --------------------TALYIA----KQN-S-PVVEVWD-----K----------- LRRK1_Hsap --------------------EVVWCL----DDK-A-NSLVMYH-----S----------- CG5483_Dmel --------------------SHVFSC----LYP-G-CMVYQWD-----V----------- LRRK2_Mmus --------------------TALYIA----KKN-S-PVVEVWD-----K----------- LRRK1_Mmus --------------------EMVWCL----DDK-A-NCLVMYH-----S----------- T27C10.5_Cele --------------------QKVWIA----LEK-S-SKVQMVE-----V----------- GbpC_Ddis ENGGGLTSSNFFGNGSDELTERDWTI----LLT-N-ASVIAYN-----RGDVVMEENAIN Pats1_Ddis --------------------NTMWVG----T--IV-NTIHIYD-----L----------- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ---------------------TFVIS----S--IE-DSFHRFKF---------------- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis -------------------------N----S--TS-SN-----LKPTPT----------- Roco6_Ddis --------------------PNVWVS----LKE-T-PSILVYN-----V----------- Roco7_Ddis --------------------ESVWSN----CKEKT-SCIKVIS-----K----------- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur --------------------GSVWCF----TSS-A-LYVYQYS-----T----------- LRRKc_Spur --------------------GSVWCF----TSS-A-LYVYQYS-----I----------- LRRKb_Spur --------------------KCLWLC----RHN-S-GVIEVWN-----T----------- LRRKa_Spur --------------------QHVWSY----VQP-G-PVVYKWN-----T----------- AqueK485_Aque --------------------QGVWSV----ARR-S-AVLRLWD-----I----------- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque --------------------TMMFVVLEDSLRP-GACCLCRVG-----V----------- AqueK489_Aque --------------------EYLWVC----FRR-L-QELVVFN-----C----------- AqueK490_Aque --------------------SLVWCF----IKT-S-LVLICWD-----A----------- AqueK491_Aque --------------------SVVCGF----SYP-G-CVLYIWE-----S----------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque --------------------TT-TDE----SES-S-PSVPIDD-----T----------- AqueK494_Aque --------------------SFVWTS----YHN-G-PFIQAWD-----I----------- AqueK495_Aque --------------------RYLWVW----FSD-H-GEIVLCD-----V----------- AqueK496_Aque --------------------DYLWVS----YRS-K-AGIVCFD-----A----------- AqueK497_Aque --------------------NKVWGI----GRQ-L-ANVIEWD-----A----------- AqueK498_Aque --------------------VWVYGA----LRH-G-QFVTVWD-----G----------- LRRK2_Hsap ----------------KTEK-L-------------------------------------- LRRK1_Hsap ----------------TTYQ-L-------------------------------------- CG5483_Dmel ----------------ISKR-I-------------------------------------- LRRK2_Mmus ----------------KTEK-L-------------------------------------- LRRK1_Mmus ----------------ATYQ-L-------------------------------------- T27C10.5_Cele ----------------EKRQ-V-------------------------------------- GbpC_Ddis THLYRIKSGAISVEKKDKEG-I-------------------------------------- Pats1_Ddis -------------------KKK-------------------------------------- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ----------------SKSN-PSSPPQIATTATATQTPTPSPISVLKPPRSLPQKPVGTT Roco6_Ddis ----------------KSKE-L-------------------------------------- Roco7_Ddis ----------------SKLK-T-------------------------------------- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ----------------ETRS-C-------------------------------------- LRRKc_Spur ----------------ETRK-C-------------------------------------- LRRKb_Spur ----------------GKQQ-L-------------------------------------- LRRKa_Spur ----------------ETRA-I-------------------------------------- AqueK485_Aque ----------------KNGE-L-------------------------------------- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ----------------VDKE-V-------------------------------------- AqueK489_Aque ----------------VKGK-A-------------------------------------- AqueK490_Aque ----------------SSCA-Q-------------------------------------- AqueK491_Aque ----------------SNNH---------------------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ----------------R-ET-L-------------------------------------- AqueK494_Aque ----------------EDGS-H-------------------------------------- AqueK495_Aque ----------------ETGE-K-------------------------------------- AqueK496_Aque ----------------RTRT-Q-------------------------------------- AqueK497_Aque ----------------KTYT-I-------------------------------------- AqueK498_Aque ----------------ASRK-I-------------------------------------- LRRK2_Hsap ---------C----------------------GL---ID-C----------------V-- LRRK1_Hsap ---------C----------------------AR---YF-C----------------G-- CG5483_Dmel ---------E----------------------NK---LD-C----------------S-- LRRK2_Mmus ---------C----------------------EL---ID-C----------------V-- LRRK1_Mmus ---------C----------------------AR---YF-C----------------G-- T27C10.5_Cele ---------T----------------------GS---LD-I----------------R-- GbpC_Ddis --------------------------------------N-CKVATMFAPKMFGEMSFL-- Pats1_Ddis ---------T----------------------KYKGKIS-L----------------D-- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ---TVPTTNK----------------------NGWVEIE-C----------------K-- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ----------------------------------------L----------------E-- Roco5_Ddis QTTSTPPTNQ----------------------TPNPTIVTR----------------PPL Roco6_Ddis ---------V----------------------TK---IS-L----------------N-- Roco7_Ddis ---------K----------------------KLMNVKT-L----------------D-- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ---------L----------------------AI---LD-C----------------R-- LRRKc_Spur ---------L----------------------AI---LD-C----------------R-- LRRKb_Spur ---------K----------------------TT---ID-I----------------R-- LRRKa_Spur ---------E----------------------GR---ID-F----------------V-- AqueK485_Aque ---------K----------------------AS---FN-V----------------R-- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ---------S----------------------G--------------------------- AqueK489_Aque ---------I----------------------YG---VN-C----------------S-- AqueK490_Aque ---------A----------------------GS---ID-L----------------T-- AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ---------KPFEMSYAPNDHSPDPRSSVMSYAR---SE-S----------------G-- AqueK494_Aque ---------S----------------------MN---IN-V----------------F-- AqueK495_Aque ---------L----------------------NS---IE-L----------------E-- AqueK496_Aque ---------R----------------------GH---IN-C----------------S-- AqueK497_Aque ---------N----------------------CV---FD-C----------------S-- AqueK498_Aque ---------K----------------------TC---FN-V----------------L-- LRRK2_Hsap -HF-------LREV---------------------------------------------- LRRK1_Hsap -VP-------SPLRDMFPVRPLDTEPPAASHTANPKVPEGDSIADVSIMYSEELGTQILI CG5483_Dmel -KL-------LPCS---------------------------------------------- LRRK2_Mmus -HF-------LKEV---------------------------------------------- LRRK1_Mmus -DP-------NPLRDTFSVQPSVLETPG-SHKTTSKGPVEECIADVSIMYSEELGTQILT T27C10.5_Cele -KV-------MPGS---------------------------------------------- GbpC_Ddis -GN--------------------------------------------------------- Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis PSS--------------------------------------------------------- Roco6_Ddis -DD--------------------------------------------------------- Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur -ES-------ILVPGSF--LPL---------------------------YQEKRQELVRS LRRKc_Spur -ES-------ILVLGSF--LPL---------------------------SQEERQELVRS LRRKb_Spur -DL-------IGEQY--------------------------------------------- LRRKa_Spur -AT-------ISTCR--------------------------------------------- AqueK485_Aque -NI-------LKGE---------------------------------------------- AqueK486_Aque -----------MQE---------------------------------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque -QV--------------------------------------------------------- AqueK490_Aque -NT--------------------------------------------------------- AqueK491_Aque -KL--------------------------------------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque -KDVPLDKPSFRSL---------------------------------------------- AqueK494_Aque -TS-------LAKQN--------------------------------------------- AqueK495_Aque -VL--------------------------------------------------------- AqueK496_Aque -DR--------------------------------------------------------- AqueK497_Aque -RV-------DPTGNILIG----------------------------------------- AqueK498_Aque -DL--------------------------------------------------------- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap HQESLTD---------YC------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus HQDSLTD---------YC------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur WEEKREKEQELASAT--------------------------------------------- LRRKc_Spur WEEK-EKEQELASATAVCETNSNGDGRFVSNQDALLQEELPIVDN--------------- LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ---------------------------------------VPSIEEFILPDSMISTIPKDS AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ---------------SMSSYSSSPPRQA--------ARSPSSLPSSPASSSSVPFSTDCE CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ---------------SMSSYSSSPPHQD--------PRSPSSLPSSLTSYSSVPFSANYE T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ---------------HFTAACIAPPRRG--------TTTRR------------------- LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ERKSPSGSPQDQLESSTSSFTSGSPHNDSGFEVSNEPENPSKM----------PYATYNA AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------M--VKE--NK-------------------------------------- LRRK1_Hsap DSDMLHTPGAA---SDRSE-----------------------HDLTPM------------ CG5483_Dmel ------------ES--LQ--SI------------------------AI------------ LRRK2_Mmus ------------M--VKL--NK-------------------------------------- LRRK1_Mmus DSDRLQEPSVT---SDRTE-----------------------HDLSPM------------ T27C10.5_Cele ------------ET--IH--TI------------------------DM------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ----LGGKRLG---GQRGKN------------------GMQRWNIHSI------------ LRRKb_Spur ---------------PDA------------------------------------------ LRRKa_Spur -----------SNPRPRG--RQ------------------------SH------------ AqueK485_Aque ------------F----------------------------------------------- AqueK486_Aque ------------M--LKG--DV-------------------------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------P--EPI--EN-------------------------PDTSKTHTEGCPF AqueK494_Aque ---------------PQG--SL------------------------AI------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque RFSRRTLRGIKP---RERTHNMSKQEGRGIFAPRPEFDALQKAKMRSI------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap -----------ESKHK---MS------------YSGRV---------------------- LRRK1_Hsap ---------DGE---T---FS------------QHLQA---------------------- CG5483_Dmel ------------DEHV---NL------------IKCQI---------------------- LRRK2_Mmus -----------ESKHQ---LS------------YSGRV---------------------- LRRK1_Mmus ---------DGE---T---FS------------QHLQA---------------------- T27C10.5_Cele ------------EMAS---QN------------YVTCI---------------------- GbpC_Ddis ---------KTT----ARL-T------------VDEESDLYVMDIPFLNNLFNGHPRLGA Pats1_Ddis -----------------------------------SPI---------------------- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis -----------------------------------GIP---------------------- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis -----------------------------------SAI---------------------- Roco5_Ddis ---------LSS----NSI-NKPPSKPLPTPGGVTSPP---------------------- Roco6_Ddis ---------QSS----DQW-G------------KTGAV---------------------- Roco7_Ddis -----------------------------------AQI---------------------- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ---------LAS---Q---SQ------------SSIKV---------------------- LRRKb_Spur -------------------RI------------SEFDV---------------------- LRRKa_Spur ------------R-PM---SA------------FRSQV---------------------- AqueK485_Aque -----------------------------------NEI---------------------- AqueK486_Aque -----------EDEPT---TV------------HRSRA---------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ---------------Y---WT------------FGIEI---------------------- AqueK489_Aque ---------IGKDRAE---V----------------WI---------------------- AqueK490_Aque ---------LTGICSQAGLES------------NNLRL---------------------- AqueK491_Aque ---------LASHKYD---QF------------TTDKV---------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque SYIVDAKQMQGGDEPT---TV------------HHSRA---------------------- AqueK494_Aque ------------E-G----GV------------YNSRV---------------------- AqueK495_Aque ---------LGDSIPS---KE------------TSSRVL--------------------- AqueK496_Aque ---------IKGK-DD---FD------------TSHQV---------------------- AqueK497_Aque ------------L-R----QQ------------GATRV---------------------- AqueK498_Aque ---------LPHW--K---ED------------AMPSV---------------------- LRRK2_Hsap ---------------------------------------KTLCL-------QKNTA--LW LRRK1_Hsap ---------------------------------------VKIL--------AVRDL--IW CG5483_Dmel ---------------------------------------SALA--------AHNSE--LY LRRK2_Mmus ---------------------------------------KALCL-------QKNTA--LW LRRK1_Mmus ---------------------------------------VKVL--------AVKDL--IW T27C10.5_Cele ---------------------------------------GLLE-R------NDGDQ--LY GbpC_Ddis KFYKIMANQLAIRLKNLPWSKPKNTTGGSSSSNQSAGPDN--------I-LGTTPT--GI Pats1_Ddis ---------------------------------------ECL--------LRRDQE--VW QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ---------------------------------------PLPMVGHSS-ILWNNSL--IV Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ---------------------------------------TAMS-------YFGNNT--LY Roco5_Ddis ---------------------------------------PPPTTSSTT-PIKFNSI---- Roco6_Ddis ---------------------------------------N--------M-MLVNNF--VW Roco7_Ddis ---------------------------------------TTILIHHSSVGAVGASR--VW Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ---------------------------------------SSLL--------VMDHV--LW LRRKb_Spur ---------------------------------------KSMMLQ-------PRTA--LW LRRKa_Spur ---------------------------------------NSMCL--------SGEY--LY AqueK485_Aque ---------------------------------------TALV--------VRGHA--VW AqueK486_Aque ---------------------------------------RSYAI-------TNETFDIDI AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ---------------------------------------SHFSI--------TTAD--LL AqueK489_Aque ---------------------------------------TC-------I-QVVLDT--VW AqueK490_Aque ---------------------------------------LS-------L-ECCQDI--IW AqueK491_Aque ---------------------------------------TD-------V-MSMGSM--LY AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ---------------------------------------GRYAL-------TNETFDIDI AqueK494_Aque ---------------------------------------TAMYLY---N-SGNKSF--LW AqueK495_Aque ---------------------------------------PALV-K------PTPHA--MW AqueK496_Aque ---------------------------------------ISLL--------AQGRR--LY AqueK497_Aque ---------------------------------------TSLLL--------VHDT--LW AqueK498_Aque ---------------------------------------SALY--------CSSSY--MY LRRK2_Hsap IGTGGGHILLLDLST--R-RL-I--RV------------------IYNFC-N--SV---- LRRK1_Hsap VPRRGGDVIVIGLEK--D-SGA--------------------------QR-G--RV---- CG5483_Dmel IGTTWGCLIVAELHT--L-RP-I--SV------------------FRPYE-N--EI---- LRRK2_Mmus IGTGGGHILLLDLST--R-RV-I--RT------------------IHNFC-D--SV---- LRRK1_Mmus VPRHGGDIIVIGLEK--D-SGA--------------------------QR-G--RV---- T27C10.5_Cele IGTSKGLLVIAHATT--L-QP-L--SA------------------CRPFE-G--DI---- GbpC_Ddis SSSG-GGLTSLLNQ-N-LSSI-M--SL--------SN---------SNTPPA--SPRVMT Pats1_Ddis VATL-GNIARIDVN-S-L-RV-V--QM--------T----------KAHE-R--A----- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis IGGWFNKARLLNQI-H-I-LN-L--ET--------F----------E------------- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis IASG-SHIVVFKTK-T-L-LM-NVNQN--------W----------KHST-G--S----- Roco5_Ddis ----SAGNKTIGQS-S-T-LP-S--ST--------------------------------- Roco6_Ddis ITGG-SKLTQIDSQ-S-Y-QL-L--EV--------H----------GNHY-S--KP---- Roco7_Ddis LGTDRGMIFILEYP-S-M-AP-I--AH--------H----------ESHG-G--AL---- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur -------------------------------------------------A---------- LRRKc_Spur IGRSNGDIVLVNIQD--N-VGSF-EEK--------M----------DVQV-G--EV---- LRRKb_Spur VGTAAGKLVLIDVNT--Y-QL-I--TV--------I----------GRHV-S--GL---- LRRKa_Spur IGISCGHLLVLDAST--L-AP-A--IL--------L----------SCHE-G--PV---- AqueK485_Aque LGTRSGYLFLLDASA--I-EN-Q--EQETAIKGFQ-YCGDGRVKGITPFP-S--SL---- AqueK486_Aque QGTCQGQLLRISCPK--P-VL-L--QT------------------LLSK----------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque LGTVTGEVLIVPMSR--L-QK-N--QN--------YFDASAAVMSIPSHK-G--SV---- AqueK489_Aque VGLNTGHILTFSAYSLTP-LL-L--TY--------F----------KPHK-E--NI---- AqueK490_Aque VGVSVGIIVLLTATPT-P-RV-I--TW--------F----------RAHR-S--SP---- AqueK491_Aque MSTGGGEVVTLSLSNS-L-QE-I--SS----PLFPI----------SAHS-KSRGI---- AqueK492_Aque ----------------------------------------------VSK----------- AqueK493_Aque QGRCQGQLLRISCPK--P-VS-L--QT------------------LLSK----------- AqueK494_Aque VGTASGHMIVFDTTT--G-SP-L--VI--------------------------------- AqueK495_Aque IGTNHGHLFGFCHVT--F-NL-L--IA--------V----------KQHS----SI---- AqueK496_Aque VGTLSGIVAVFDSES--L-GL-I--AS--------F----------NWHT-G--KV---- AqueK497_Aque IARGMGDVLVVDISG--G-KN-HGMAI--------------------------------- AqueK498_Aque IGLVTGEILVLDHLH--L-SL-L--TT--------L----------HCHR-S--NV---- LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis TPTLPSPPAPLQSPPTSGISSPTTTTSTTTDQQKINNTIFQNVHPTINVHRTSSSANLVS Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ------------------------------------------------------------ AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap -----------------RV----------------------------------------- LRRK1_Hsap -----------------IA----------------------------------------- CG5483_Dmel -----------------KS----------------------------------------- LRRK2_Mmus -----------------RA----------------------------------------- LRRK1_Mmus -----------------IA----------------------------------------- T27C10.5_Cele -----------------TS----------------------------------------- GbpC_Ddis PHGRPSNSGFGHSSGGERTINKDPHQRDSGSMDKPILSLGSGGTPRGDGARSGSISYLGR Pats1_Ddis ----------------IHA----------------------------------------- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ----------------ITS----------------------------------------- Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ----------------ITS----------------------------------------- Roco7_Ddis ----------------IHT----------------------------------------- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur -----------------VT----------------------------------------- LRRKb_Spur -----------------RS----------------------------------------- LRRKa_Spur -----------------KF----------------------------------------- AqueK485_Aque -----------------KV----------------------------------------- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque -----------------LD----------------------------------------- AqueK489_Aque -----------------RQ----------------------------------------- AqueK490_Aque -----------------RC----------------------------------------- AqueK491_Aque -----------------YK----------------------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque -----------------ES----------------------------------------- AqueK496_Aque -----------------RT----------------------------------------- AqueK497_Aque -----------------AR----------------------------------------- AqueK498_Aque -----------------HS----------------------------------------- LRRK2_Hsap -----------------------------------MMTAQL------------------- LRRK1_Hsap -----------------------------------VLKAREL------------------ CG5483_Dmel -----------------------------------IITLSKD------------------ LRRK2_Mmus -----------------------------------MATAQL------------------- LRRK1_Mmus -----------------------------------VLKAREL------------------ T27C10.5_Cele -----------------------------------ICILEEP------------------ GbpC_Ddis TQTSTSPLNEGLSGGQQPVMKKNDQEFCQRFALVDEIVIKDYPC---------------- Pats1_Ddis -----------------------------------MIQVDDHVW---------------- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis -----------------------------------ILAMKDEVW---------------- Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis -----------------------------------MALVEKNVW---------------- Roco7_Ddis -----------------------------------IKRMDRFV----------------- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur -----------------------------------VLNADAV------------------ LRRKb_Spur -----------------------------------ILAVNKG------------------ LRRKa_Spur -----------------------------------VIPVAPS------------------ AqueK485_Aque -----------------------------------LCSIEYS------------------ AqueK486_Aque -------------------------------------VKME------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque -----------------------------------VAILE-------------------- AqueK489_Aque -----------------------------------LVLLQPSYWNPDVHSKFYDDESVTT AqueK490_Aque -----------------------------------LITVPDA------------------ AqueK491_Aque -----------------------------------LL----------------------- AqueK492_Aque -------------------------------------V---------------------- AqueK493_Aque -------------------------------------VKME------------------- AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque -----------------------------------IVSTGS------------------- AqueK496_Aque -----------------------------------LLLLPEQ------------------ AqueK497_Aque -----------------------------------LATEDSS------------------ AqueK498_Aque -----------------------------------FLSIDLR------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ------------------------------------------------------------ Pats1_Ddis ------------------------------------------------------------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque DSDCGTVPFSPISGTYGGSVPSNPSLPAQNVVIPEVCSVLSCGQGVYKPIPKISEDGILL AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ----------------------------------SLNRSGRLYISQQHVCFYSKFFG--- Pats1_Ddis ----------------------------------TASSDGTIKVWSSTC--------QSV QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ----------------------------------SGGSDGRIYIWKVKN-------EFEL Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ----------------------------------ISCEDESLSVWDGDT-------GSFI Roco7_Ddis ----------------------------------ITCSERVICIFD-ES--------GII Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque HDTDPVNGLCVLKMDGPDASGCIKLECQAQR-QSRPYM---------------------- AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque -----------------------KLGCRVFPRHWLPTL---------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis -----------YKTKKVIPFKNIDKLICINVNQIELTRLKNTVPSNYRLTFQTGKDREDA Pats1_Ddis HT--IENAHS---------------------------------SRIF-----------TL QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis QKVQSLEAHH---------------------------------EKIT-----------SL Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis RKV---GSPIGSPT----------------------------KPTVYT----------KL Roco7_Ddis KK--RLDGLA---------------------------------SRVL-----------SL Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ---QQLQQ-Q---------------------------------KQSP-----------KQ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ---------ANYNE---------------------------------------------- AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ---------IGRNN---------------------------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------TP---------------------------------------------------- CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------NR---------------------------------------------------- T27C10.5_Cele ------S----------------------------------------------------- GbpC_Ddis FSMIHILWD-SSK----VSNSSSDE----------------------------------- Pats1_Ddis ELVGDFVWSGSWDTTIKIWSTK---D---------------------------------- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ---------------WNQFVC--------------------------------------- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis IHLEDNVLSGSTDKCISLFKIS---D---------------------------------- Roco5_Ddis ---------------LKQFTA--------------------------------------- Roco6_Ddis LYFSGYVWA-CTQGSIHIYCIHSLT----------------------------------- Roco7_Ddis LILDTYIIGACYDSTILVWDSK--QN---------------------------------- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis L------------------------Q---------------------------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------VK---------------------------------------------------- LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------HH----------------HH---------------------------------- AqueK485_Aque ------D----------------------------------------------------- AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ----------------------ALYTNVSRATSFNESHRLLPPTPSVNNEATPNELSSDV AqueK490_Aque ------SV----------------DN---------------------------------- AqueK491_Aque ----------------------AIEY---------------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------VK----------------AC---------------------------------- AqueK497_Aque -------K---------------------------------------------------- AqueK498_Aque ------KL----------------LP---------------------------------- LRRK2_Hsap ----------------------GNL----------------------------------- LRRK1_Hsap ---------------------HGVL--VDA-------A--VV------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ----------------------GSL----------------------------------- LRRK1_Mmus ---------------------HGVL--VDA-------A--VV------------------ T27C10.5_Cele -REE---ENTRGKA--TTLST-----ASSESGL-GW--VRERVSE-TVDRF--------- GbpC_Ddis I--KN--------------------------K-LA--AERKKVNNLTLKTRSNKNKGDEL Pats1_Ddis Y--HLV-------------------------S-EN--S--GK----------H------- QkgA_Ddis F--DSP------------------------------------------------------ QkgA_C2d_Ddis F--DSP------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis P--KKP-------------------------F-TT--Q--EH----------H------- Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis C--KK--------------------------K-VE--S--KN----------H------- Roco7_Ddis F--RMV-------------------------Q-SL--K--KK----------H------- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis Q--QKP-------------------------L-PT--P---------------------- LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur -----------GD--------NGRV--VEL-------H--RT------------------ LRRKb_Spur -----------------L----GVG----------------------------------- LRRKa_Spur LVPDLPD--S------SII---PDHQ----SEVAVAHR--FR------------------ AqueK485_Aque --------------------------EVSGCIM-VW--E--------------------- AqueK486_Aque ----------------------GNF----------------------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ---------G------HIE---PNGYTSFFSTFLGRQR--ER------------------ AqueK489_Aque Y--ESI-------------------------VLS------PK----------H------- AqueK490_Aque F--QVV-------------------------L-SG--G--FG----------E------- AqueK491_Aque Y--KEL-------------------------L-D------EE----------E------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ----------------------GNF----------------------------------- AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque VCAEVPFDDGEATATEKVFKSNSNWTNNPCYL----NN--TL------------------ AqueK497_Aque -----------------Y----GNR----------------------------------- AqueK498_Aque PQQE---YQGLGAMTPTVYPSHPFLTNSDQSDV---KY--KT------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------RSSPAT------ GbpC_Ddis TKEDWELIGCEGSRSSTFKKDEVIIREGERMQKIFQIGKGVCRIEKSVPVAPGSSEMKKV Pats1_Ddis ---------------------------------------------------KDA------ QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ---------------------------------------------------KQG------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ---------------------------------------------------PNS------ Roco7_Ddis ---------------------------------------------------TDA------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque ---------------------------------------------------DPE------ AqueK490_Aque ---------------------------------------------------HSY------ AqueK491_Aque ---------------------------------------------------MAE------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ----------------------------------------------------------AK CG5483_Dmel -----------------------------------------------------------N LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ----------------------------------------------------------AK T27C10.5_Cele -------------------------------------------------------VETQG GbpC_Ddis VLGTMKQDDTFGEITYLLNGETTADVIADTDQT--------------------------- Pats1_Ddis ----------------------ISS------FVYI------------------------S QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ----------------------VTS------IVKV------------------------- Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ----------------------IVD------LI--------------------------- Roco7_Ddis ----------------------ISS------LAFA--------------------LSPQG Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ----------------------------------------------------------GS LRRKb_Spur ----------------------------------------------------------KN LRRKa_Spur ----------------------------------------------------------FS AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ----------------------------------------------------------MD AqueK489_Aque ----------------------LAD------FICITPSDVPSHLSDDTPVPSRTHSFVNH AqueK490_Aque ----------------------IRS----------------------------------- AqueK491_Aque ----------------------IK-----------------------------SGIIGSQ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ----------------------------------------------------------TD AqueK497_Aque ----------------------------------------------------------SN AqueK498_Aque ----------------------------------------------------------GP LRRK2_Hsap ------------KNVM-LVLG--YN----------------------------------- LRRK1_Hsap -------------DTV-VCT---FE----------------------------------- CG5483_Dmel ------------VPLI-ATIGRRYRSLI----------SR------------YV------ LRRK2_Mmus ------------KNVM-LVLG--YK----------------------------------- LRRK1_Mmus -------------DTV-VCS---FA----------------------------------- T27C10.5_Cele ------------AALV-VCIGRQFRSLS----------HR------------FV------ GbpC_Ddis ------------------------------------------------EVYT-------- Pats1_Ddis NDQPLQTNERPIQKQV-WS---------GSW-------------DSSICVWA-------- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis --------------------------------------------QS-HIVWA-------- Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------KPQL-WV---------GGWDKKITTYSFFEDLESSLS----------- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur -------------NRV-VSC---HD----------------------------------- LRRKb_Spur ------------ESVV-VTAGMGFVQ---------------------------------- LRRKa_Spur ------------RPTV-VTLGKGFNDLVG----------------------GYG------ AqueK485_Aque -----------------------YQS---------------------------------- AqueK486_Aque ------------QDVKDFDMA--YS----------------------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------VPFL-LSVGPGSLDF--------------------------G------ AqueK489_Aque ------------SPIV-AP---------VSPGFQP-----MSPSVQPKSPGV-------- AqueK490_Aque ---------------------------------------------------S-------- AqueK491_Aque ------------SQLL-VT---------IGHGFEG------------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------QNIKDFSMA--YR----------------------------------- AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque -------------DCI-LAFGQW------------------------------------- AqueK496_Aque ------------HSLV-ASIGNG------------------------------------- AqueK497_Aque ------------HKL--CLVGNEFVV--S----------------------SQWLEPLDM AqueK498_Aque -------------LQL-MSFGTGFRA---------------------------------- LRRK2_Hsap -------RKNTEGTQK-Q------------------------------------------ LRRK1_Hsap -------NENTE------------------------------------------------ CG5483_Dmel -------DSAES-STKS------------------------------------------- LRRK2_Mmus -------RKSTEGIQE-Q------------------------------------------ LRRK1_Mmus -------NENTE------------------------------------------------ T27C10.5_Cele -------AEEK------------------------------------------------- GbpC_Ddis -----------------I---------------------------------EGQ------ Pats1_Ddis -----------------LPNDTNSRSN---------------------TIFSSDS----- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis -----------------------TG----------------------------------- Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis -----------------I------------------------------------------ Roco5_Ddis -----------------------NN----------------------------------- Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------PKQLSNN----------------------------------- LRRKd_Spur --------ER-----TVN------------------------------------------ LRRKc_Spur -------NKKSD--NSVS------------------------------------------ LRRKb_Spur -------RPGV---PHLT------------------------------------------ LRRKa_Spur -------NSPSR-FTG-Q------------------------------------------ AqueK485_Aque -----------T-SSKT------------------------------------------- AqueK486_Aque -------EGD-SG----------------------------------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque -------KVGKS-QKSEK------------------------------------------ AqueK489_Aque -----------------LPASTS---DPPTSPSVQPTSPSVQPKSPGVLPVSTSDPPVSP AqueK490_Aque -----------------A------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque -------QGD-SG----------------------------------------------- AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque PRPRAQTDAGIF-GDQVD------------------------------------------ AqueK498_Aque -------YYESN--DTID------------------------------------------ LRRK2_Hsap ------------------------------------------------------------ LRRK1_Hsap ------------------------------------------------------------ CG5483_Dmel ------------------------------------------------------------ LRRK2_Mmus ------------------------------------------------------------ LRRK1_Mmus ------------------------------------------------------------ T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ----------------------------------FVNILFDLNPALAS------------ Pats1_Ddis ----------------QFNLNGGSSNSITNSNSNSNNNLNGNLNNSNNSINNNYNNNNNN QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ------------------------------------------------------------ Roco11_Ddis ------------------------------------------------------------ Roco4_Ddis ------------------------------------------------------------ Roco5_Ddis ------------------------------------------------------------ Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------------------ Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis ------------------------------------------------------------ LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur ------------------------------------------------------------ LRRKb_Spur ------------------------------------------------------------ LRRKa_Spur ------------------------------------------------------------ AqueK485_Aque ------------------------------------------------------------ AqueK486_Aque ------------------------------------------------------------ AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque SVPLLSPKPPLSPSAHQSSDNDHDD-GLPLTDSE--------------DEGEGYVRM--- AqueK490_Aque ------------------------------------------------------------ AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ------------------------------------------------------------ AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque ------------------------------------------------------------ AqueK498_Aque ------------------------------------------------------------ LRRK2_Hsap --------------------------------KE----------------------IQSC LRRK1_Hsap ----------------------------------------------------------WC CG5483_Dmel -----------------------------SAVSTPTHGAAK----------SV------- LRRK2_Mmus --------------------------------KE----------------------IQSC LRRK1_Mmus ----------------------------------------------------------WC T27C10.5_Cele ------------------------------------------------------------ GbpC_Ddis ----------------------------------------K------------------- Pats1_Ddis NNNNNNNNNNNNNNNNNNNNNNNNNYYYSNNVNSPNQAS-QSAGHLGTIHEQTSPNSATP QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis ---------------------------------------------------DIPPSSIAA Roco11_Ddis ----------------------------------------------------------HP Roco4_Ddis --------------------------------TS----------------D-----TTTP Roco5_Ddis ---------------------------------------------------NTSPSGSSS Roco6_Ddis ------------------------------------------------------------ Roco7_Ddis ------------------------------------------------IALQTPPPSS-- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis --------------------------------------------------------DSTP LRRKd_Spur ------------------------------------------------------------ LRRKc_Spur --------------------------------QI------------------------KK LRRKb_Spur --------------------------------ES----------------------NYSY LRRKa_Spur --------------------------------ER----------------------LGWY AqueK485_Aque -----------------------------QALVSPTQS---------------------- AqueK486_Aque ---------------------------------E-----------------------VVC AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque --------------------------------AV----------------------TGT- AqueK489_Aque ---------------------------KSASVSQPPKAYKPLHKFLD-KSRSLPPARYQP AqueK490_Aque --------------------------------SH----------------------DNGV AqueK491_Aque ------------------------------------------------------------ AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque ---------------------------------E-----------------------VVC AqueK494_Aque ------------------------------------------------------------ AqueK495_Aque ------------------------------------------------------------ AqueK496_Aque ------------------------------------------------------------ AqueK497_Aque --------------------------------AI----------------------AHQQ AqueK498_Aque --------------------------------YT----------------------KSSF LRRK2_Hsap LTVWDI------------NLPHEVQ-NLE-KHIE-VRKE--------------------- LRRK1_Hsap LAVWRG------------WGAREFD-IFY-QSYEE-LG---------------------- CG5483_Dmel ------P----------------------PADVD-NHIH--------------------- LRRK2_Mmus LSIWDL------------NLPHEVQ-NLE-KHIE-VRTE--------------------- LRRK1_Mmus LAVWRG------------WGAREFD-IFY-QSYEE-LG---------------------- T27C10.5_Cele --------------------------------LA-DVYS--------------------- GbpC_Ddis ---WF-------------------KY-LA----TA-LNK--------------------- Pats1_Ddis LS--STPPGSKG--------------LMQRRTVSF-MNV--------------------- QkgA_Ddis ------------------------------------------------------------ QkgA_C2d_Ddis ------------------------------------------------------------ Roco10_Ddis LN--ITLHGDYLLAYYERTDSIKQQIFRL-----S-LDS--------------------- Roco11_Ddis DLI-----------------------------------S--------------------- Roco4_Ddis LVLWNIP-----------------------QKWEK-KTA--------------------- Roco5_Ddis LP--N------------STVSSPSSSFLLR----P-TGG--------------------- Roco6_Ddis ------------------------KV-FQ----QT-VWS--------------------- Roco7_Ddis -----YP-------------------TLA----TP-RLG--------------------- Roco8_Ddis ------------------------------------------------------------ Roco9_Ddis --------------------------------TKP-LDD--------------------- LRRKd_Spur -----------------------II-RP--RSVG-QLSV--------------------- LRRKc_Spur MCVWED------------WGQVQVE-QF--QTINNQCRK--------------------- LRRKb_Spur ALVWDA------------ELKNQVR-YLQ-ADAE-RRKKTTESNTTRWHKISETCTSLSR LRRKa_Spur ILLWNM------------EYFNEDR--LE-LGND-FLDG--------------------- AqueK485_Aque --------------------------------LQ-PVNK--------------------- AqueK486_Aque INS--Q------------DKFDQYM-EME-NRPN-------------------------- AqueK487_Aque ------------------------------------------------------------ AqueK488_Aque ------------------------------------------------------------ AqueK489_Aque LGL---------LESTDSGDSIP----------SN-PSS--------------------- AqueK490_Aque IMSWQG------------MSSDELE-TLA-RRWRE-R-K--------------------- AqueK491_Aque ------------LSSLKRGDSWQ----------DH-NN---------------------- AqueK492_Aque ------------------------------------------------------------ AqueK493_Aque INS--Q------------DKFDQFM-EME-KRPN-LLLQ--------------------- AqueK494_Aque ---------------------------TK-RHIN-PIRS--------------------- AqueK495_Aque ----A----------------CD--------GSPE-HSN--------------------- AqueK496_Aque ----R----------------LQFM-TES-KTGPT-RGD--------------------- AqueK497_Aque LTVWGA------------WSNEVIC-AQA-QQVS-DMIE--------------------- AqueK498_Aque LLVWEA------------AGWG---------------K---------------------- LRRK2_Hsap -----LAE----------------KMRRTSVE LRRK1_Hsap ------RL----------------EACTRKRR CG5483_Dmel -----CLL----------------W-RAKHWT LRRK2_Mmus -----LAD----------------KMRKTSVE LRRK1_Mmus ------RL----------------EACTRKRR T27C10.5_Cele -----IAV----------------WRTEEWAL GbpC_Ddis -----TLI----------------ERESQLYA Pats1_Ddis -----LER----------------FSNDKNRK QkgA_Ddis -------F----------------LKNYPASI QkgA_C2d_Ddis -------F----------------LKNYPASI Roco10_Ddis -----FIW----------------FSLKLSNV Roco11_Ddis -----NG-----------------VPKLQIAK Roco4_Ddis -----NGI----------------LPRLKFFR Roco5_Ddis -----TIS----------------KKLPAIPK Roco6_Ddis -----CCG----------------TNNVCIWS Roco7_Ddis -----LVN----------------VSKSKLFG Roco8_Ddis -------------------------DSTINSK Roco9_Ddis -----SSD----------------SSSEDSNN LRRKd_Spur -----FAY----------------KLARRPQF LRRKc_Spur -----RTR----------------KSGTYLEV LRRKb_Spur PCSPLSPY----------------MRVNGGPV LRRKa_Spur -----IVR----------------KKSRSTEV AqueK485_Aque -----YRI----------------ESEFLCDS AqueK486_Aque -------L----------------LLHASTSQ AqueK487_Aque -----------------------------MEY AqueK488_Aque -------------------------CINLWLV AqueK489_Aque -----PAK----------------KLTPEKKY AqueK490_Aque -----DKE----------------EAEDESRV AqueK491_Aque ------NF----------------VLLWLPPR AqueK492_Aque -------T----------------FQSIMGSC AqueK493_Aque -----V-S----------------ASTSTDGE AqueK494_Aque -----I-Q----------------SIKTTSNY AqueK495_Aque -----IAG----------------SQTASSPM AqueK496_Aque -----RSSKMERRKTGMFSLYTEDINLLIWHS AqueK497_Aque -----LDY----------------QASSGYES AqueK498_Aque ------NV----------------LSQEKRQD