CLUSTAL W (1.83) multiple sequence alignment LRTK2_Mbre MSNRPWA-----SRLPGWGLLCITLVLLC--WPL--------AAQIDMPG-------CPK LRTK4_Mbre MGVACAAVVQARPCRRGWRRVLYAVLLS-CTWLSGAGPALVEGADLAFPG-------CPL LRTK5_Mbre MAIQAGP-------------VVCALALA-FTALVAGAVAQPAQQL-TGPGTCANGTACPY LRTK1_Mbre MTGRGGT---------GCRGLVAGVVLLGWGWLLAG----LDGVNGQAVG-------CRL LRTK3_Mbre MRVTWQG------W-RGSGSTLVVVVVA-VVVLSQL----PSTWTQDVPG-------CSL * : : * * LRTK2_Mbre H--------L----------------IDPADG-FG------------------------- LRTK4_Mbre K--------I----------------VHPHNTEFS------------------------- LRTK5_Mbre QWGPDGHLPSFHPGLDATARFSYTPYIQSLLG-DDYDVMHSPDDHRDGGAADANCQSDYW LRTK1_Mbre S--------Q----------------LRSQEG-VD------------------------- LRTK3_Mbre H--------Q----------------IEPMSG-LD------------------------- : . . LRTK2_Mbre ------------------------------------------------------------ LRTK4_Mbre ------------------------------------------------------------ LRTK5_Mbre YNYADNLTSIAEHMASWATASNTKLLFALTSAELCDVGLDDTVLRLNEEAAGIMAQFHIP LRTK1_Mbre ------------------------------------------------------------ LRTK3_Mbre ------------------------------------------------------------ LRTK2_Mbre -----------------F---LC--------------------------FDCDKPMLF-N LRTK4_Mbre -----------------NRPGDV--------------------------YSCTPPP-L-E LRTK5_Mbre TVNLHDPIVAKCGPVPQQ---QCFGLEALATTPSTAPEPVFCTPNHLNPYECKSNGTV-I LRTK1_Mbre -----------------E---PC--------------------------FTCTRLADSGG LRTK3_Mbre -----------------F---RC--------------------------WDCDSSIAGSR : * LRTK2_Mbre RYIPVGATCVLRPTSNLTDSCRENVYWTKFTCARDNRFYLDPSGVMSDYFSAVNCVVSWS LRTK4_Mbre DLVQIGSICQLNTSSEIVQQSPQDLPWGTLRCNAQLVFLTVPDTPLSPFYQSLGCEVTWD LRTK5_Mbre TRIPAGFLCEL--------ACISNTMWSRVRCTDDGFFVSDPSGSLCPAYTAAGCT--YD LRTK1_Mbre LWAGFGATCYTDVTSE---FCLARYYWTAYVCKSVGYFTLDHEGEMTAHFAAAGCVVEFD LRTK3_Mbre RYVPKGAVCVYQTSN-PNRYC-GHPIWSRYVCHGDNQFYIDRAGH--SLLDKYNCSISFD * * . * * * .* :. LRTK2_Mbre AASNRPSLDCDGSG-LP-RLQKLTSLPYGGAPADLEHLRVRHHRVMDIAFVDTYGLANLT LRTK4_Mbre AHG-FAALDCDGRRAQTLGQPYLREMPHGGMPFNLRRLTLRHHLIRSIFHHNVFALQQLQ LRTK5_Mbre LAA--GALSCDGRGV-S-PEDKLTNLIRYSGHTELRSLDFQYQYIRAISNNDMHGLRGLR LRTK1_Mbre NET-RPSLVCDGSRGSG-QTNKLKAAPLGGAPYDLKRLVIRHHLIDGFADTQTTLLQQLE LRTK3_Mbre RTE-GVHILCDGRFA-S---NPMTVLPDSGAPPNVKTLIVRHHAIDQIPVRKTFAAQQLE : *** : . ::. * .::: : : . * LRTK2_Mbre SFDVSNNRITELGVGAFSYLMRLSHLNLSSNRLTVVTPRDLPMLQNLQTLDLSSNPLQTI LRTK4_Mbre ELDVSHNRISMISQSALAQAPELLYLNLSHNILETLRPEHMPNLHALRVLDLRGNTFREL LRTK5_Mbre KLRVASSHISALEGTLFITMPHVQSIDLAYNVLDTITPGMMMAERQLRFINLTGNPITAI LRTK1_Mbre TLDLSHNQILSER-LDMRSLLGLRFCNLSHNKLTLVQARMLPTQNNLLLLDTSANNLTVV LRTK3_Mbre HLDLSFNNITSISGVSMLSLTGLRHFNISHNRITRLHPDLLPFNNRLDVLDVRGNDIQIL : :: ..* : : ::: * : : . : . * :: .* : : LRTK2_Mbre RTDLLLAPMHADCTS---IRLPS-ACGPV--PGCHALLP-GPPAASTRATTEAL--STST LRTK4_Mbre QADLLAIVMSPDCEA---VYLPE-GCYRVEPQSCRSLIA-SSNTS--------------- LRTK5_Mbre EAGAFNYSFSRSCSVSSTIVLDDTNC------SCQAAPAPHCNTQTCSCL-------GQH LRTK1_Mbre RADLLVSSMSSSCEG---VILPS-HCSFV-YDTCQAVLR-HASNASVP---SLD--SGSE LRTK3_Mbre RADTFVSAMRSNCAA---LLLPD-TCNPP-IVPCNAFLA-TDPTGSASATPTIIDLTSSS .:. : : .* : * . * *.: LRTK2_Mbre TVVGATTSVVTSNTTAASSTPAFAQDCHVVSHASHWPCAAAHGQEPTSLPFHQLCDGHVD LRTK4_Mbre -------------------------LCNVVK-PVLLPCSNESSTAPAMITATAYCDGVVD LRTK5_Mbre MGP----------------------------APVVLPCTPSLT-DGPVFEQAQLCDGVRD LRTK1_Mbre ANDGSCIL----------------------TTSPNLTC-----PSGVSIFPYQYCDGVED LRTK3_Mbre TTTTTTTTTTTNSSEFGLSTVRPAASCRVVDTSVTLTCR-----SGATYRASQLCDGIPD . .* *** * LRTK2_Mbre CADASDEQQCEQLWDTTGIDVLDDCTGSRFHASWRYGVFFGRPLDEMA-VYPCLYVSHLP LRTK4_Mbre CANGADEVDCTQLWQVQGMDVLQQCSNGILQATWYKGLLNLYPTDPFY-VSLCAGFLHAL LRTK5_Mbre CPCGRDERFCSNLIDVSDS-LFGRCFGLPVAVDVSYGLARIFTNDSNYTTSTCFTVPL-T LRTK1_Mbre CGDGWDEWRCCQLWNTSKELLFPDCGANPMMLQYHFGHAQIGPPVYSL-AVQCGLPLLMP LRTK3_Mbre CPDADDEEACTQVWDTSEAFLIKDCTSGRMVVRFDHGHVFARSEDESV-VVPCFTLTY-L * . ** * :: :. :: * . * . . * LRTK2_Mbre YTVFVADVFVLIDD-NVPQWRGPYIA--VAQAV----------VDFYLTRHRLLANGTAF LRTK4_Mbre SIRIVAAPNASSPR-ADIVWTSIL-----DERF----------AFVEASRTTIYLLIKQA LRTK5_Mbre GLGWGLDIFTFNSETATAIWLSEFNINLLGRLSIQLLWYPDDSWIFVFNVTDVSPHVQEP LRTK1_Mbre FLAYFMDTPVLNAN-GQAEWSGAE-----DKGS----------LTLILNRTDMILNYQAG LRTK3_Mbre RLMYFGSTKPSEEE-GQPQWRFSSV---EDRLT----------IHYDLNRTTLSIHAYID * . . : LRTK2_Mbre GHEIGIDLKLDNL--------Q------LPFPS-TAFSTLMPATT-ARI---AVQSSSGS LRTK4_Mbre VH---NGPSESDW-------PII-------LASTTSATPGQPNST-AGTF---TTASSPS LRTK5_Mbre LHQVLVPDFVAN---PN---AS------CDLAS-TTATPSEPA------LKNAVSNASPS LRTK1_Mbre AGAVVAHIAEDEVQTVDCATVKVLGGWNTPAPSNSPVASTAPALTVAPTA--AASSGSSS LRTK3_Mbre GSELATSYTLAN--------LI------ILTKS-TTDAPRLPGTTTPHSLSTARQAHGPQ : * :. :. * . . LRTK2_Mbre N----LLSLAVILPIVVG--LCALILGLIYERRRRLQRRLMQALRAS-----------GA LRTK4_Mbre HHAKRVQTIVVIVIALVGLGVILAVAGVVFWRRGQHHHLLQGLGGLASAQVLERAI-IGI LRTK5_Mbre T----TLLISISLAALV---VLALATAVFLY-TRRKPKSI-E------------------ LRTK1_Mbre H----LVTIVVAVTVTLA--TVLVVLILLWDRTRR-QRRVKQLFADDVESTLEHQMLNTL LRTK3_Mbre H----VVVFATIAGALL---LCAVGATILIR-RARRRRPI-PLDDVSNEQVLAQRLQVAL : : :. : : : LRTK2_Mbre ADGN-HTD--------VLAK-LQAYELDAASVVVDGPTLHRGNFGIVRRG-LICA--THE LRTK4_Mbre ALSEHKPL-LERLEL-WCAD-MQSNRIA-ASQVHVREQLSRGRFGAIYLG-ALTF--QSA LRTK5_Mbre --------------------------FQ-PNQVEFEHELGHGAFGAVFLA-TLHQGEKRS LRTK1_Mbre ATHALSDT--------VVQG-LGEHQLA-AGAVVSSSVLHRGTFSVVKLG-RLMP--HVQ LRTK3_Mbre ARTTTSPTAGAKFDSMSVAAVPKSKLIP-SEEFQIQQTLRKGTRSLLYRVRAPLL--GTQ : . . * :* . : LRTK2_Mbre DIVAKCQATG---L-SQ-AAILLETTMLMLA-QSPNVVGLKGFLR-NGDLG--LMLCLEY LRTK4_Mbre PVIIKEPLSS---TPEAVSMAISELLLLGAC-RHENIAKVIGVFS-QGDGSLAPTLVISY LRTK5_Mbre TVVVKQAHQTEATAIESALHLLLEAHMMAISRQHPCILQICGLH--LGDSTL--T-ASEY LRTK1_Mbre PVAIKEMDGK---A-AC-AMGMLEVAMLLAA-RHPRVVRLEGFVLDQSKHH--ISICTEY LRTK3_Mbre DTVLKCATHA---AEEHRLGMLLEITLLQLA-QHDRVVTLLGHTT-LPDGRP--GLFMPH * : * :: . : : : * . : LRTK2_Mbre CAGGNLLQVLRGSRAT-SSLSPRHLLQA-SLQTARALQYLSHLGMIHRDVAARNILVRSV LRTK4_Mbre YAGGDLRSYLQRHRGW-QELPDAHFVTAIVCQLASALAHLASLQVVHRDVAARNVLLVHA LRTK5_Mbre CAGE------------------------------PKLPSQASLNIVHRDVAARNVLLLNA LRTK1_Mbre LPGGSLLNWLRELRKKAQQIQVPQFLDA-AFGLAEALQYLAHIGLVHRDVAARNVLVRKE LRTK3_Mbre LPGGSLLDFLRAQRQQ-NFLSERWMVAV-ALQIASGVQHLHGCGIIHRDIAARNVLLQQA .* : ::***:****:*: LRTK2_Mbre SDH-----GLQAALGDFGHARLVGRDSTPS------INQQSSGLGSTVST------V-QE LRTK4_Mbre NGLT---TEPKVVLSDFGHARVMQRSGSGR------ALRGAT---GDENG------E-LD LRTK5_Mbre YVLGSHMQTPMVKLGDFGHARLLHSGEATV------ASE--DGFAANPAL---------- LRTK1_Mbre AMG-----TLQVVLADFGHARLLSSLARPL------PVDLKAF-EEDDAT------E-SS LRTK3_Mbre VADP---FAVEVVLSDFGHARLLTRGTEGSENNPDPATDMSAGMASNPVFESGPSRDDEA . *.******:: LRTK2_Mbre SSPDEYYRQASLIETAARWQPPEVLAQSLFTLASDAWSFGVLLYEIWTLGQVPYGDLVRE LRTK4_Mbre EDSGQYYRQRGLLETATRWQPPEVLREDRFSPASDAWSLGVLMYEVWTFGQVPYAEVVRE LRTK5_Mbre -EAADYYLQQSTITVASRWHAPEVLRSQRFSLSSDVWSFGVFLHELTTLGTVPYADIQSE LRTK1_Mbre VDEAGYYRQQSLLETAARWQPPEVLQEQRFSIASDTWSYGVVLFEMWSLGQTPYADLQRE LRTK3_Mbre AHGGEYYRQHSTIQTAVRWQPPESLARDSFSPASDMWSYGVLLYELWSMGQTPYVEVVSE ** * . : .* **:.** * . *: :** ** **.:.*: ::* .** :: * LRTK2_Mbre ADVVAAILQNGRRLPVPPRLAE---LPDRVSKMYQRLQEDVAPRRPGWQAVL--REHTLA LRTK4_Mbre ADVLRAILR-GARLALPEGVRS---RAPQLFKLWQSLQATEPERRPVGDQVV------LH LRTK5_Mbre QECISRILQ-GLCLHPPPGSPT------AVAQAMQRCLSKDPHRRGQFEAL--------H LRTK1_Mbre ADVIRAVLD-GRRLAVPPVGSK---FPPRLAKVS-RL--GVPSARPSWQEVL--RELGIY LRTK3_Mbre ANVATAIMQ-GYPLQLSVEARTGFAQVPGLFELWGRLMVFAPGRRASSAEAVGLLQHAVH : :: * * . : : . * LRTK2_Mbre -------------------------------LQTL-------------T-YPDPHVNSEA LRTK4_Mbre -------------------------------LKAE-------------D-GEPKEEESAV LRTK5_Mbre ES-----------------------------FQAEIA---------------ERQQESEL LRTK1_Mbre LANALSLHNSKELSKKGTNYIRSQAKQAQRMLQARNGSAS-----GSAHHKSALSTPSAL LRTK3_Mbre LS-----------------------------QQATVAAPSRAWCDGSLG-EIDNFNESQL :: *