CLUSTAL W (1.83) multiple sequence alignment MNK2_Hsap_MNK MVQKKPAELQ-G--------FH----RSF------------------------------- MNK1_Hsap_MNK MVSSQKLEK--------------------------------------------------- MAPKAPK5_Hsap_MK5 MSEESDM----------------------------------------------------- MAPKAPK3_Hsap_MK2 MDGETAEEQG-------------------------------------------------- MAPKAPK2_Hsap_MK2 MLSNSQGQSP-------------------------------------------------- MAPk-Ak2_Dmel_MK2 MLSLQN------------------------------------------------------ Lk6_Dmel_MNK MVEPKSGTAA-S--------AA-----AA------------------------------- MNK2_Mmus_MNK MVQKRTAELQ-G--------FH----RSF------------------------------- MNK1_Mmus_MNK MGSS-------------------------------------------------------- MAPKAPK5_Mmus_MK5 MSEDSDM----------------------------------------------------- MAPKAPK3_Mmus_MK2 MDGETAGEKG-------------------------------------------------- MAPKAPK2_Mmus_MK2 MLSGSPGQTP-------------------------------------------------- R166.5_Cele_MNK MTILHAGYPQ-S-------P-V----VHF-----GRHHNVNINQLNLNHLGQVDNIPNNS K08F8.1_Cele_MK2 MMFEYEEDED-P--------MEQQKHEEFKHHSTD------------------------- C44C8.6_Cele_MK2 MQIRVLCVST----------------ADFS------------------------------ MAPKAPK2_Spur_MK2 MIR--------------------------------------------------------- MAPKAPK5a_Spur_MK2 MDFRTGF----------------------------------------------------- MAPKAPK5b_Spur_MK5 MSLFTPITNLRL--------------GG-------------------------------- Mnk_Spur_MNK MGNDRGKQAI-VYKKQVLQPVM----RSF------------------------------- AqueK073_Aque_MK2 MSSHPLTGKA-------------------------------------------------- AqueK074_Aque_MK5 MRRVSGAIDF----------------VY-------------------------------- AqueK075_Aque_MNK MEGTASRAAS-------------------------------------------------- * MNK2_Hsap_MNK ------------------------------------------------------------ MNK1_Hsap_MNK ------------------------------------------------------------ MAPKAPK5_Hsap_MK5 ------------------------------------------------------------ MAPKAPK3_Hsap_MK2 ------------------------------------------------------------ MAPKAPK2_Hsap_MK2 ------------------------------------------------------------ MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------ Lk6_Dmel_MNK --------------KASNNN-----------NNN--------------HPRG-SGDSGIR MNK2_Mmus_MNK ------------------------------------------------------------ MNK1_Mmus_MNK ------------------------------------------------------------ MAPKAPK5_Mmus_MK5 ------------------------------------------------------------ MAPKAPK3_Mmus_MK2 ------------------------------------------------------------ MAPKAPK2_Mmus_MK2 ------------------------------------------------------------ R166.5_Cele_MNK AVGGGGAAFHHLHTSAATPRHVATSEFYDDEEAT--------------SPRG-GIEIGAG K08F8.1_Cele_MK2 --------------HSGS------------------------------------------ C44C8.6_Cele_MK2 ------------------------------------------------------------ MAPKAPK2_Spur_MK2 ------------------------------------------------------------ MAPKAPK5a_Spur_MK2 ------------------------------------------------------------ MAPKAPK5b_Spur_MK5 ------------------------------------------------------------ Mnk_Spur_MNK ------------VFPTVCPQ------------DS--------------YPS--------- AqueK073_Aque_MK2 ------------------------------------------------------------ AqueK074_Aque_MK5 ------------------------------------------------------------ AqueK075_Aque_MNK ------------------------TKMEDREEIRDLLQFKHDFTLGLVSENGSSKTNGSI MNK2_Hsap_MNK ------------------------KGQNPFELAFSL----------D------------- MNK1_Hsap_MNK ----------------------------PI------------------------------ MAPKAPK5_Hsap_MK5 ------------------------------------------------------------ MAPKAPK3_Hsap_MK2 --------------------------G-P----------------VP------------- MAPKAPK2_Hsap_MK2 --------------------------PVPFP--------------AP------------A MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------ Lk6_Dmel_MNK SGSGISCSNTDNSCSQSQS-----DGQNELTRYSS------------------------- MNK2_Mmus_MNK ------------------------KGQNPFELAFSL----------D------------- MNK1_Mmus_MNK ------------------------------------------------------------ MAPKAPK5_Mmus_MK5 ------------------------------------------------------------ MAPKAPK3_Mmus_MK2 --------------------------S-L----------------VP------------- MAPKAPK2_Mmus_MK2 --------------------------PAPFP--------------SP------------- R166.5_Cele_MNK GGKMM---------ANLRRHRQ--RERETYEDEDVL----------S------------- K08F8.1_Cele_MK2 ------------------------PQENPFRFSYDTGKRAASMFVTPSSEDLIAYGTKHL C44C8.6_Cele_MK2 --------------------------PKNLL--------------GP------------S MAPKAPK2_Spur_MK2 ------------------------------------------------------------ MAPKAPK5a_Spur_MK2 ------------------------------------------------------------ MAPKAPK5b_Spur_MK5 --------------------------STPIA--------------PD------------N Mnk_Spur_MNK ------------------------QETTPIT---------------K------------- AqueK073_Aque_MK2 --------------------------PPDFA----------------------------- AqueK074_Aque_MK5 --------------------------KLPFW--------------SY------------S AqueK075_Aque_MNK DGKMG---------AAEKRNDESIKSLKEFQKSFKL----------G------------- MNK2_Hsap_MNK ------------------------------------------------------QPD--- MNK1_Hsap_MNK ------------------------------------------------------------ MAPKAPK5_Hsap_MK5 ------------------------------------------------------------ MAPKAPK3_Hsap_MK2 ------------------------------------------------------PPVA-- MAPKAPK2_Hsap_MK2 ------------------------------------------------------PPPQ-- MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------ Lk6_Dmel_MNK ------------------------------------------------------------ MNK2_Mmus_MNK ------------------------------------------------------LAQ--- MNK1_Mmus_MNK ------------------------------------------------------------ MAPKAPK5_Mmus_MK5 ------------------------------------------------------------ MAPKAPK3_Mmus_MK2 ------------------------------------------------------PPGA-- MAPKAPK2_Mmus_MK2 ------------------------------------------------------PPPA-- R166.5_Cele_MNK ------------------------------------------------------SSD--- K08F8.1_Cele_MK2 -----------------LD-----------------------------------SPTAVQ C44C8.6_Cele_MK2 SLIFRVFFGGFLYANVKLE-----------------------------------APEA-- MAPKAPK2_Spur_MK2 ------------------------------------------------------------ MAPKAPK5a_Spur_MK2 ------------------------------------------------------------ MAPKAPK5b_Spur_MK5 Q---------------AVYITEVDAQKRFARCGEPLIAMVCSDHTIKLVGKETMSSAG-- Mnk_Spur_MNK ------------------------------------------------------MPT--- AqueK073_Aque_MK2 ------------------------------------------------------------ AqueK074_Aque_MK5 ---------------------------RLQRREEALLT----------------LPVA-- AqueK075_Aque_MNK ------------------------------------------------------KSE--- MNK2_Hsap_MNK -----------------HGDSDF-----GL---QCSAR--PD-----------M------ MNK1_Hsap_MNK -----------------------------------------E-----------M------ MAPKAPK5_Hsap_MK5 ------------------------------------------------------------ MAPKAPK3_Hsap_MK2 -----------------------------P---GGP-----------------G------ MAPKAPK2_Hsap_MK2 -----------------------------P---PTP-----------------A------ MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------ Lk6_Dmel_MNK --------------------EDV----SGN---ESSEA--PN-----------M------ MNK2_Mmus_MNK -----------------HRDSDF-----SP---QCEAR--PD-----------M------ MNK1_Mmus_MNK ------------------------------------------------------------ MAPKAPK5_Mmus_MK5 ------------------------------------------------------------ MAPKAPK3_Mmus_MK2 -----------------------------L---GGS-----------------A------ MAPKAPK2_Mmus_MK2 ------------------------------------------------------------ R166.5_Cele_MNK -----------------E----------------SSGRPIPR-----------YVGRDTD K08F8.1_Cele_MK2 RSLVLNATTSLNIDCDLSSDDDL-----SP---TTQRK--ICF----------C------ C44C8.6_Cele_MK2 -----------------------------Q--KSTR------GSFFSRIGCCLS------ MAPKAPK2_Spur_MK2 ------------------------------------------------------------ MAPKAPK5a_Spur_MK2 ------------------------------------------------------------ MAPKAPK5b_Spur_MK5 -----------------------------QLKGHGGP----------------V------ Mnk_Spur_MNK ------------------GD--------KM---TVSQR--P------------------- AqueK073_Aque_MK2 -----------------------------A------------------------------ AqueK074_Aque_MK5 -----------------------------SL-LFGS-----------------I------ AqueK075_Aque_MNK -----------------QSNSVLSPHVNGS---DCSQREVPR-----------SLD---- MNK2_Hsap_MNK -------------------------------PA--------------------S---QP- MNK1_Hsap_MNK -------------------------------GS--------------------S---EP- MAPKAPK5_Hsap_MK5 ------------------------------------------------------------ MAPKAPK3_Hsap_MK2 -------------------------------LG--------------------G------ MAPKAPK2_Hsap_MK2 -------------------------------LP--------------------H---PP- MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------ Lk6_Dmel_MNK -------------------------------TE--------------------V---ERQ MNK2_Mmus_MNK -------------------------------PS--------------------S---QP- MNK1_Mmus_MNK ---------------------------------------------------------EP- MAPKAPK5_Mmus_MK5 ------------------------------------------------------------ MAPKAPK3_Mmus_MK2 -------------------------------LG--------------------G---AP- MAPKAPK2_Mmus_MK2 ----------------------------------------------------------P- R166.5_Cele_MNK HVFGEFEMDDEDVVMRREDGYGEDETDEDYFDE--------------------E---EP- K08F8.1_Cele_MK2 -------------------------------AS--------------------Q---NP- C44C8.6_Cele_MK2 -------------------------------TK--------------------S---SP- MAPKAPK2_Spur_MK2 ------------------------------------------------------------ MAPKAPK5a_Spur_MK2 ------------------------------------------------------------ MAPKAPK5b_Spur_MK5 -------------------------------SGVKFAHRNPFTVFSSSRDGTVRCWDTR- Mnk_Spur_MNK -------------------------------PA--------------------T---AA- AqueK073_Aque_MK2 -----------------------------------------------------H---VP- AqueK074_Aque_MK5 -------------------------------TG--------------------N--LIN- AqueK075_Aque_MNK -------------------------------IT--------------------A---QP- MNK2_Hsap_MNK IDI-P-----------------------------------------DAKKRGKK-KK-RG MNK1_Hsap_MNK LPI-A-----------------------------------------DGDRRRKK-KR-RG MAPKAPK5_Hsap_MK5 ------------------------------------------------------------ MAPKAPK3_Hsap_MK2 -----------------------------------------------A---------P-G MAPKAPK2_Hsap_MK2 AQP-P----------------------------------------PPPPQQFPQ-FHV-K MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------ Lk6_Dmel_MNK AEL-N----------------------------------------RHKEEMQKK-RR-KK MNK2_Mmus_MNK IDI-P-----------------------------------------DAKKRGRK-KK-RC MNK1_Mmus_MNK LPI-V-----------------------------------------DSDKRRKK-KR-KT MAPKAPK5_Mmus_MK5 ------------------------------------------------------------ MAPKAPK3_Mmus_MK2 -----------------------------------------------A---------P-G MAPKAPK2_Mmus_MK2 AQP-P----------------------------------------PP----FPQ-FHV-K R166.5_Cele_MNK VAE-L-------------------------------------LPLGGGTRRVPR-TP-GR K08F8.1_Cele_MK2 AET-Q----------------------------------------EQGL--RPA-KSTLA C44C8.6_Cele_MK2 AEK-I----------------------------------------K-P---------P-D MAPKAPK2_Spur_MK2 ------------------------------------------------------------ MAPKAPK5a_Spur_MK2 ------------------------------------------------------------ MAPKAPK5b_Spur_MK5 MKRNK----------------------------------------APQV--F--TG---- Mnk_Spur_MNK VQM-PDCKATAENYANNNIADETCLLSEQMDLMMSISSVEDFHSGLDDSRRKRK-KK-KK AqueK073_Aque_MK2 -----------------------------------------------S---------A-Q AqueK074_Aque_MK5 RKR-S----------------------------------------KPQN--LSLMSKY-E AqueK075_Aque_MNK VSR-G-------------------------------------QANTSKKKKQKK-KR-LK MNK2_Hsap_MNK RATDS-FSGRFEDV--YQLQ---------------------------------------- MNK1_Hsap_MNK RATDS-LPGKFEDM--YKLT---------------------------------------- MAPKAPK5_Hsap_MK5 -DKA-IKETSILEE--YSINW--------------------------------------- MAPKAPK3_Hsap_MK2 GRRE-PKKYAVTDD--YQLS---------------------------------------- MAPKAPK2_Hsap_MK2 SGLQ-IKKNAIIDD--YKVT---------------------------------------- MAPk-Ak2_Dmel_MK2 -QRQ-PKTTPLTDD--YVTS---------------------------------------- Lk6_Dmel_MNK RISSSLHSSTFQEL--YKLT---------------------------------------- MNK2_Mmus_MNK RATDS-FSGRFEDV--YQLQ---------------------------------------- MNK1_Mmus_MNK RATDS-LPGKFEDV--YQLT---------------------------------------- MAPKAPK5_Mmus_MK5 -EKA-IKETSILEE--YSINW--------------------------------------- MAPKAPK3_Mmus_MK2 VRRE-PKKYAVTDD--YQLS---------------------------------------- MAPKAPK2_Mmus_MK2 SGLQ-IRKNAITDD--YKVT---------------------------------------- R166.5_Cele_MNK -K-NS-SKCGFFDY--YKLT---------------------------------------- K08F8.1_Cele_MK2 ISFP-CHQHQITED--YTIS---------------------------------------- C44C8.6_Cele_MK2 EIMA-FHEYPVTQD--YRIS---------------------------------------- MAPKAPK2_Spur_MK2 ------------------------------------------------------------ MAPKAPK5a_Spur_MK2 -----FETVSILED--YTIDW--------------------------------------- MAPKAPK5b_Spur_MK5 -----YEGN-SFTSFDINSTDDILSAGTEAVDNDAYLMFWDRRSTNLLGTYKESHSDDIT Mnk_Spur_MNK RTSGI-VPNRFEDV--YDLT---------------------------------------- AqueK073_Aque_MK2 KPLI-PKKHAITGD--YTIL---------------------------------------- AqueK074_Aque_MK5 RDPE-FKKTSILDD--YEIKW--------------------------------------- AqueK075_Aque_MNK PIPDD-IDYSFNDL--YELT---------------------------------------- MNK2_Hsap_MNK --------EDVLGEGAH-ARVQTCINLITSQEYAVKIIEKQPG-HIRSRVFREVEM---- MNK1_Hsap_MNK --------SELLGEGAY-AKVQGAVSLQNGKEYAVKIIEKQAG-HSRSRVFREVET---- MAPKAPK5_Hsap_MK5 --------TQKLGAGIS-GPVRVCVKKSTQERFALKILLDRP------KARNEVRL---- MAPKAPK3_Hsap_MK2 --------KQVLGLGVN-GKVLECFHRRTGQKCALKLLYDSP------KARQEVDH---- MAPKAPK2_Hsap_MK2 --------SQVLGLGIN-GKVLQIFNKRTQEKFALKMLQDCP------KARREVEL---- MAPk-Ak2_Dmel_MK2 --------NTVLGYGIN-GKVVQCTHRRTQQNYALKVLLDSE------RARREVDL---- Lk6_Dmel_MNK --------GEILGEGAY-ASVQTCVNIYTDLEYAVKVIDKIPG-HARARVFREVET---- MNK2_Mmus_MNK --------EDVLGEGAH-ARVQTCVNLITNQEYAVKIIEKQLG-HIRSRVFREVEM---- MNK1_Mmus_MNK --------SELLGEGAY-AKVQGAVNLQSGKEYAVKIIEKQAG-HSRSRVFREVET---- MAPKAPK5_Mmus_MK5 --------TQKLGAGIS-GPVRVCVKKSTQERFALKILLDRP------KARNEVRL---- MAPKAPK3_Mmus_MK2 --------KQVLGLGVN-GKVLECYHRRSGQKCALKLLYDSP------KARQEVDH---- MAPKAPK2_Mmus_MK2 --------SQVLGLGIN-GKVLRIFDKRTQQKFALKMLQDCP------KARREVEL---- R166.5_Cele_MNK --------DEHLGSGAY-GSVTTCKSIKSGVEYAVKIVDKQGETHSRKRILREVNI---- K08F8.1_Cele_MK2 --------AEIIGIGES-GKVMACYQKVTGEKFALKVLRDSQ------KARREVEL---- C44C8.6_Cele_MK2 --------RKVLGVGIN-GKVVECEHRQSGDKFALKVLRDTQ------KARREVEL---- MAPKAPK2_Spur_MK2 ------------------------------------------------------------ MAPKAPK5a_Spur_MK2 --------TQKLGTGIN-GPVRPCQHKRSEDRFALKLLLDKP------GARAEVNL---- MAPKAPK5b_Spur_MK5 QVKFHPTKSSSLATGSTDGLVCVFDTSQTNEEDALVTTLNSE------SSVSHIDWCGTN Mnk_Spur_MNK --------GELLGSGSY-ASVRTCRQISSGKEYAVKMMEKRPG-NSRTKIFREVET---- AqueK073_Aque_MK2 --------TRSLGVGVN-GKVLECIHKATGERRALKILRENP------KSRRELDL---- AqueK074_Aque_MK5 --------NRSLGTGVS-GPVRLCIHRATGKEYALKLLLDRSD---RKKAEIEATL---- AqueK075_Aque_MNK --------SEILGSGAR-ATVITCIKRTTRQQYAAKIINNSGP-EVRDRVLKEVEI---- MNK2_Hsap_MNK --LYQCQGHRNVLELIEFFEEE------------------------------DRFYLVFE MNK1_Hsap_MNK --LYQCQGNKNILELIEFFEDD------------------------------TRFYLVFE MAPKAPK5_Hsap_MK5 --HMMCATHPNIVQIIEVFANSV--QFPH------------------ESSPRARLLIVME MAPKAPK3_Hsap_MK2 --HWQASGGPHIVCILDVYENMH--H------------------------GKRCLLIIME MAPKAPK2_Hsap_MK2 --HWRASQCPHIVRIVDVYENLY--A------------------------GRKCLLIVME MAPk-Ak2_Dmel_MK2 --HWRVSGCRYIVNIIDVYENTF--K------------------------DRKCLLVVME Lk6_Dmel_MNK --FHHCQGHLGILQLIEFFEDD------------------------------EKFYLVFE MNK2_Mmus_MNK --LYQCQGHRNVLELIEFFEEE------------------------------DRFYLVFE MNK1_Mmus_MNK --LYQCQGNRNILELIEFFEDD------------------------------TRFYLVFE MAPKAPK5_Mmus_MK5 --HMMCATHPNIVQIIEVFANSV--QFPH------------------ESSPRARLLIVME MAPKAPK3_Mmus_MK2 --HWQASGGPHIVRILDVYENMH--H------------------------GKRCLLIVME MAPKAPK2_Mmus_MK2 --HWRASQCPHIVHIVDVYENLY--A------------------------GRKCLLIVME R166.5_Cele_MNK --FKTCKDHPNIVQLLDWFEDE------------------------------TNFYLVME K08F8.1_Cele_MK2 --HWLTNAHENVVSILDIYENTF--D------------------------NVKCLLMVVE C44C8.6_Cele_MK2 --HVMASGHGHVVSVHDVYKNSY--N------------------------GVDCLLVVME MAPKAPK2_Spur_MK2 ------------------------------------------------------------ MAPKAPK5a_Spur_MK2 --HSRCSGHANIVKIIEVFSNEV--QFPG------------------EPAPKSRLLVVME MAPKAPK5b_Spur_MK5 SEYLYCLTHTETIRIFDAVESSEITKFDSVRESLKEDRCKVDYLVDCFYHSGLKSLVVLG Mnk_Spur_MNK --LYHCQGHNNILQLIEYFEDD------------------------------DRFYLIFE AqueK073_Aque_MK2 --HWRSCSHENIVNICDVYENVF--M------------------------GHRSLLVVME AqueK074_Aque_MK5 --HWRCSGGDHIVRIVDIYRNEI--QQPG------------------ELSPKKRILLVME AqueK075_Aque_MNK --LYSCSSCDNFLKIEDFFETS------------------------------EKFYLVFE MNK2_Hsap_MNK KMRGGSILS--HIHKR--RHFNELEASVVVQDVASALDFLHNK----------------- MNK1_Hsap_MNK KLQGGSILA--HIQKQ--KHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSG MAPKAPK5_Hsap_MK5 MMEGGELFH--RISQH--RHFTEKQASQVTKQATLALRHCHLL----------------- MAPKAPK3_Hsap_MK2 CMEGGELFS--RIQERGDQAFTEREAAEIMRDIGTAIQFLHSH----------------- MAPKAPK2_Hsap_MK2 CLDGGELFS--RIQDRGDQAFTEREASEIMKSIGEAIQYLHSI----------------- MAPk-Ak2_Dmel_MK2 CMEGGELFQ--RIQDKADGAFTEREAAQIMHEICAAVDYLHSR----------------- Lk6_Dmel_MNK KINGGPLLS--RIQEH--ICFSEHEASQIIKEIASGLDFLHKK----------------- MNK2_Mmus_MNK KMRGGSILS--HIHRR--RHFNELEASVVVQDVASALDFLHNK----------------- MNK1_Mmus_MNK KLQGGSILA--HIQKR--KHFNEREASRVVRDVATALDFLHTK----------------- MAPKAPK5_Mmus_MK5 MMEGGELFH--RISQH--RHFTEKQASQVTKQIALALQHCHLL----------------- MAPKAPK3_Mmus_MK2 CMEGGELFS--RIQERGDQAFTEREAAEIMRDIGTAIQFLHSR----------------- MAPKAPK2_Mmus_MK2 CLDGGELFS--RIQDRGDQAFTEREASEIMKSIGEAIQYLHSI----------------- R166.5_Cele_MNK KMRGGPLLQ--HILQR--KYFTEEEARRVTKDISLALKFMHDR----------------- K08F8.1_Cele_MK2 FLEGGDLLS--QFESQGSIPYTEKKVGEIIRQIGNAVMYLHDM----------------- C44C8.6_Cele_MK2 NMKGGELFN--RIQERGQKAFTEREAAGIVNEICSAVAHLHRM----------------- MAPKAPK2_Spur_MK2 ----------------------LTEAAEIVRSIGQAVHHLHVM----------------- MAPKAPK5a_Spur_MK2 LMDGGELFD--RISKQ--KRFTERQAVILTKQIASAVLQCHSL----------------- MAPKAPK5b_Spur_MK5 GTVGGDLHLLTVGKDR--------------------LHFVHSL----------------- Mnk_Spur_MNK KMYGGALLQ--HIEQR--GTFTEQEASQVIRDIASALSFLHNK----------------- AqueK073_Aque_MK2 CMEGGELFD--RIQDK--GHFTEREAAEVVRCISLAVAHLHHM----------------- AqueK074_Aque_MK5 LMEGKELFD--YISKR--HHFTEHEASKYILQIVRGVQFCHRL----------------- AqueK075_Aque_MNK KMEG-PLLE--LIQKR--ERFTEREASEVTREVAAALSFLHRQ----------------- : * MNK2_Hsap_MNK ------------------------GI--------AHRDLKPENILCEHP---NQVSPVKI MNK1_Hsap_MNK LTAAPTSLGSSDPPTSASQVAGTTGI--------AHRDLKPENILCESP---EKVSPVKI MAPKAPK5_Hsap_MK5 ------------------------NI--------AHRDLKPENLLFKDN---SLDAPVKL MAPKAPK3_Hsap_MK2 ------------------------NI--------AHRDVKPENLLYTSK---EKDAVLKL MAPKAPK2_Hsap_MK2 ------------------------NI--------AHRDVKPENLLYTSK---RPNAILKL MAPk-Ak2_Dmel_MK2 ------------------------DI--------AHRDLKPENLLYTTT---QPNATLKL Lk6_Dmel_MNK ------------------------GI--------AHRDLKPENILCVKT---DSLCPIKI MNK2_Mmus_MNK ------------------------GI--------AHRDLKPENILCEHP---NQVSPVKI MNK1_Mmus_MNK ------------------------GI--------AHRDLKPENILCESP---EKVSPVKI MAPKAPK5_Mmus_MK5 ------------------------NI--------AHRDLKPENLLFKDN---SLDAPVKL MAPKAPK3_Mmus_MK2 ------------------------NI--------AHRDVKPENLLYTSK---EKDAVLKL MAPKAPK2_Mmus_MK2 ------------------------NI--------AHRDVKPENLLYTSK---RPNAILKL R166.5_Cele_MNK ------------------------GI--------AHRDVKPENVLCTDP---NHVSPVKL K08F8.1_Cele_MK2 ------------------------NI--------AHRDIKLENILCSGT---GDNCVYKL C44C8.6_Cele_MK2 ------------------------SI--------AHRDLKPENLLYVTT---ASNAALKL MAPKAPK2_Spur_MK2 ------------------------NI--------AHRDLKPENLLYRDR---TPNSLLKL MAPKAPK5a_Spur_MK2 ------------------------NI--------AHRDLKPENLLLKDN---SEDSPVKL MAPKAPK5b_Spur_MK5 ------------------------KGTHKGVVRCLHWDNQTETLVTGGEDSI---VSAWQ Mnk_Spur_MNK ------------------------GI--------AHRDLKPENILCESM---YSISPIKI AqueK073_Aque_MK2 ------------------------DI--------AHRDLKPENLLYSDK---TPSAKLKL AqueK074_Aque_MK5 ------------------------NI--------AHRDIKPENLLLLKPASNPEDVVIKL AqueK075_Aque_MNK ------------------------GI--------AHRDLKPENILCQTK---DEVVPIKV * * : *.:: MNK2_Hsap_MNK CDFDL--------GSGIKLNGD-CS----PISTPELLTPCGSAEYMAP-EVVEAFS---- MNK1_Hsap_MNK CDFDL--------GSGMKLNNS-CT----PITTPELTTPCGSAEYMAP-EVVEVFT---- MAPKAPK5_Hsap_MK5 CDFGF--------AKID---------------QGDLMTPQFTPYYVAP-QVLEAQRRHQK MAPKAPK3_Hsap_MK2 TDFGF--------AKETT--------------QNALQTPCYTPYYVAP-EVLG------- MAPKAPK2_Hsap_MK2 TDFGF--------AKETTS-------------HNSLTTPCYTPYYVAP-EVLG------- MAPk-Ak2_Dmel_MK2 TDFGF--------AKETFT-------------SYTLQTPCYTPYYVAP-EVLG------- Lk6_Dmel_MNK CDFDL--------GSGIKFTTDISS----PAATPQLLTPVGSAEFMAP-EVVDLFV---- MNK2_Mmus_MNK CDFDL--------GSGIKLNGD-CS----PISTPELLTPCGSAEYMAP-EVVEAFS---- MNK1_Mmus_MNK CDFDL--------GSGVKLNNS-CT----PITTPELTTPCGSAEYMAP-EVVEVFR---- MAPKAPK5_Mmus_MK5 CDFGF--------AKVD---------------QGDLMTPQFTPYYVAP-QVLEAQRRHQK MAPKAPK3_Mmus_MK2 TDFGF--------AKETT--------------QNALQTPCYTPYYVAP-EVLG------- MAPKAPK2_Mmus_MK2 TDFGF--------AKETTS-------------HNSLTTPCYTPYYVAP-EVLG------- R166.5_Cele_MNK CDLDL--------ASQRPPQHE-RHPLSQVASEPDLASPVGSAEFMAP-EVVDAYV---- K08F8.1_Cele_MK2 GDYGF--------AKRPER-------------NVLMESPCCTPFYAPP-EVLG------- C44C8.6_Cele_MK2 TDFGF--------AKKTDES-----------EPQGLKTACFTPYYCAP-EVLG------- MAPKAPK2_Spur_MK2 TDFGF--------AKETT--------------TTNLQTPCYTPYYVAP-EVLG------- MAPKAPK5a_Spur_MK2 SDFGF--------AKVD---------------DGTLMTPHFTPYYVAP-QVSTSLT---- MAPKAPK5b_Spur_MK5 PDRNANQSSSKKGSPAQ---------------TSRIRQGRRAEKRGSPVKVLEAQKRQRR Mnk_Spur_MNK CDFGL--------GSGIHLSSQYNT----PVTTPELLTPVGSAEFMAP-EIVEAFIY--- AqueK073_Aque_MK2 TDFGF--------AKENHG-------------SKALTTPCYTPYYVAP-EVLG------- AqueK074_Aque_MK5 SDFGF--------AKVD---------------NGDLKTPQFTPYYVAP-QVLEAQKRQKE AqueK075_Aque_MNK CDFDL--------SSMMSQH----T----PATTPNLFTPVGSAEYMAP-EVLDTFT---- * . . : : .* :: MNK2_Hsap_MNK ---------EEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGS-DCGWDRGEACPACQN MNK1_Hsap_MNK ---------DQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGA-DCGWDRGEVCRVCQN MAPKAPK5_Hsap_MK5 EKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHS-----------RTIPK MAPKAPK3_Hsap_MK2 -----------PEKYDKSCDMWSLGVIMYILLCGFPPFYSNTG------------QAISP MAPKAPK2_Hsap_MK2 -----------PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHG------------LAISP MAPk-Ak2_Dmel_MK2 -----------PEKYDKSCDIWSLGVVMYIIMCGFPPFYSNHG------------LAISP Lk6_Dmel_MNK ---------GEAHYYDKRCDLWSLGVIAYILLCGYPPFSGNCGE-DCGWNRGENCRTCQE MNK2_Mmus_MNK ---------EEASIYDKRCDLWSLGVILYILLSGYPPFVGHCGS-DCGWDRGEACPACQN MNK1_Mmus_MNK ---------DEATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGA-DCGWDRGEVCRMCQN MAPKAPK5_Mmus_MK5 EKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHS-----------RTIPK MAPKAPK3_Mmus_MK2 -----------PEKYDKSCDMWSLGVIMYILLCGFPPFYSNTG------------QAISP MAPKAPK2_Mmus_MK2 -----------PEKYDKSCDMWSLGVIMYILLCGYPPFYSNHG------------LAISP R166.5_Cele_MNK ---------GDSLKYDKKCDTWSLGVILYIMLAGYAPFQGMCDDEDCGWSEGKPCEDCQQ K08F8.1_Cele_MK2 -----------RERYDKSCDMWSLGVAMYILLCGYPPFYSMKG------------VALSP C44C8.6_Cele_MK2 -----------TEKYDKSCDLWSIGVIMYILLCGYPPFYSQHG------------QPMSP MAPKAPK2_Spur_MK2 -----------PEKYDKSCDMWSLGVIMYILLCGFPPFYSNHG------------MAISP MAPKAPK5a_Spur_MK2 ---------PI------------------------------------------------- MAPKAPK5b_Spur_MK5 EQKNLIQTSPRPYTYDKGCDMWSLGVIIYIMLCGYPPFYPDTPS-----------RQLSK Mnk_Spur_MNK --------DLQATVYDKRCDLWSLGVILYILLCGHPPFVGSCGE-DCGWDRGEACQDCEE AqueK073_Aque_MK2 -----------PEKYDTSCDMWSIGVITYILLCGFPPFYSYGG------------APISP AqueK074_Aque_MK5 SLSGY--KHRTPYYYDKSCDIWSIGVIMYIMLCGYPPFYSEVPH-----------QALSN AqueK075_Aque_MNK ---------GEIFSYDKKCDLWSLGVLVYMMLSGSPPFTGGCRT-DCGWEKGEECEKCQA MNK2_Hsap_MNK MLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLS------------------ MNK1_Hsap_MNK KLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLS------------------ MAPKAPK5_Hsap_MK5 DMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLT------------------ MAPKAPK3_Hsap_MK2 GMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLT------------------ MAPKAPK2_Hsap_MK2 GMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMT------------------ MAPk-Ak2_Dmel_MK2 GMKNRIRTGQYDFPDPEWTNVSQAAKDLIKGMLNVDPSKRLR------------------ Lk6_Dmel_MNK LLFESIQEGHFSFPEAEWHDVSDEAKDLISNLLVKKASNRLS------------------ MNK2_Mmus_MNK MLFESIQEGKYEFPDKDWSHISFAAKDLISKLLVRDAKQRLS------------------ MNK1_Mmus_MNK KLFESIQEGKYEFPDKDWAHISNEAKDLISKLLVRDAKQRLS------------------ MAPKAPK5_Mmus_MK5 DMRKKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLT------------------ MAPKAPK3_Mmus_MK2 GMKRRIRLGQYSFPNPEWLDVSEDAKQLIRLLLKTDPTERLT------------------ MAPKAPK2_Mmus_MK2 GMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMT------------------ R166.5_Cele_MNK DLFHRIQDGYYEFPEEEWGMISEEAKDLVSNLLKRDPVDRLVTVSFVNPFANRIRLTLVA K08F8.1_Cele_MK2 GMRSRIANAYYAFPHEEWDCVSKDTKDDIRCLLRTNPSDRLT------------------ C44C8.6_Cele_MK2 GMKAKIKSGQYTFPSPEWDCVSEAAKDLIRKLLRTEPTERIT------------------ MAPKAPK2_Spur_MK2 GMKRRIRNGQYEFPDPEWSQVSEDAKNLIKKLLRTDPAERLS------------------ MAPKAPK5a_Spur_MK2 ------------------------------------------------------------ MAPKAPK5b_Spur_MK5 DMRHKIMAGQYEFPTEEWSLISDEAKDVVKRLLRVDPTERLT------------------ Mnk_Spur_MNK LLLHCIQSGEYDFHGAEWEHISAGAKDLISHLLVRDAKQRYT------------------ AqueK073_Aque_MK2 GMKKRIRQGQYGFPDPEWTNVSSQAKDLIKGLLKTNPADRFT------------------ AqueK074_Aque_MK5 RMKQKIMSADFDFPENDWKAVTDEAKDLIRKMLCVEPSERLS------------------ AqueK075_Aque_MNK ILLEKIGKGQYSFPQEIWASISSEAKDLISSLLQRDVRKRLS------------------ MNK2_Hsap_MNK --------------------------------------AAQVLQHPWVQGC--APE---- MNK1_Hsap_MNK --------------------------------------AAQVLQHPWVQGQ--APE---- MAPKAPK5_Hsap_MK5 --------------------------------------IEGVLDHPWLNST-EALD---- MAPKAPK3_Hsap_MK2 --------------------------------------ITQFMNHPWINQSMVVPQ---- MAPKAPK2_Hsap_MK2 --------------------------------------ITEFMNHPWIMQSTKVPQ---- MAPk-Ak2_Dmel_MK2 --------------------------------------IQDVISNKWIAQYNAVPQ---- Lk6_Dmel_MNK --------------------------------------AEAVLNHPWIRMCEQEPPASKH MNK2_Mmus_MNK --------------------------------------AAQVLQHPWVQGC--APE---- MNK1_Mmus_MNK --------------------------------------AAQVLQHPWVQGQ--APE---- MAPKAPK5_Mmus_MK5 --------------------------------------IEGVLDHPWLNST-EALD---- MAPKAPK3_Mmus_MK2 --------------------------------------IMQFMNHPWINQSMVVPQ---- MAPKAPK2_Mmus_MK2 --------------------------------------ITEFMNHPWIMQSTKVPQ---- R166.5_Cele_MNK QSVACAIPTQPIVGSIPSYPALSLFIDCGAWKWRRKFNADQILSHRWLQQS--AAS---- K08F8.1_Cele_MK2 --------------------------------------IHELMATPLVTGEPIVPG---- C44C8.6_Cele_MK2 --------------------------------------IEQTMEHKWISHYRRVPD---- MAPKAPK2_Spur_MK2 --------------------------------------IQEFMNSPWVRQCSAVPA---- MAPKAPK5a_Spur_MK2 ------------------------------------------------------------ MAPKAPK5b_Spur_MK5 --------------------------------------IEELCSHPWLREN-SAPN---- Mnk_Spur_MNK --------------------------------------AGMVLNHPWVKQ---PPS---- AqueK073_Aque_MK2 --------------------------------------IDDVLRHRWIAGYQEVPQ---- AqueK074_Aque_MK5 --------------------------------------IEEVLHHPWLAQN-ASPN---- AqueK075_Aque_MNK --------------------------------------ADEVLAHPWIKTE--VPD---- MNK2_Hsap_MNK ----NTLPTPMVLQRNS------------------------------------------- MNK1_Hsap_MNK ----KGLPTPQVLQRNS------------------------------------------- MAPKAPK5_Hsap_MK5 ----NVLPSAQLMM-DK------------------------------------------- MAPKAPK3_Hsap_MK2 ----TPLHTARVLQEDK------------------------------------------- MAPKAPK2_Hsap_MK2 ----TPLHTSRVLKEDK------------------------------------------- MAPk-Ak2_Dmel_MK2 ----TPLCTGRMLKEAE------------------------------------------- Lk6_Dmel_MNK GRRHKALQTPSNIRRNH------------------------------------------- MNK2_Mmus_MNK ----NTLPTPLVLQRNS------------------------------------------- MNK1_Mmus_MNK ----RGLPTPQVLQRNS------------------------------------------- MAPKAPK5_Mmus_MK5 ----NVLPSAQLMM-DK------------------------------------------- MAPKAPK3_Mmus_MK2 ----TPLYTARVLQEDK------------------------------------------- MAPKAPK2_Mmus_MK2 ----TPLHTSRVLKEDK------------------------------------------- R166.5_Cele_MNK ----TILQTPSNLINRK------------------------------------------- K08F8.1_Cele_MK2 ----KHITTAIAIPGADESECGGGVFDDGFIVEEEETPDTVAEILPVPKSVRFLRDGVKA C44C8.6_Cele_MK2 ----TPLFTSSNLNDQR------------------------------------------- MAPKAPK2_Spur_MK2 ----TPLHTSSVMKEEGV------------------------------------------ MAPKAPK5a_Spur_MK2 ------------------------------------------------------------ MAPKAPK5b_Spur_MK5 ----TELHSPAIML-DK------------------------------------------- Mnk_Spur_MNK ----TPLLTPAIIKRNN------------------------------------------- AqueK073_Aque_MK2 ----TPLACIQVLQDDK------------------------------------------- AqueK074_Aque_MK5 ----RDLNSPYLIS-DK------------------------------------------- AqueK075_Aque_MNK ----TPLKTPGVLRLNP------------------------------------------- MNK2_Hsap_MNK -CAKDLTSFAAEAIAMNRQLAQHD----E------------------------------- MNK1_Hsap_MNK -STMDLTLFAAEAIALNRQLSQHE----E------------------------------- MAPKAPK5_Hsap_MK5 AVVAGIQQAHAEQLANMRIQDLKVSL---------------------------------- MAPKAPK3_Hsap_MK2 DHWDEVKEEMTSALATMRVDYDQVKI---------------------------------- MAPKAPK2_Hsap_MK2 ERWEDVKEEMTSALATMRVDYEQIKI---------------------------------- MAPk-Ak2_Dmel_MK2 ETWPEVQEEMTRSLATMRVDYDQMQI---------------------------------- Lk6_Dmel_MNK QSAREISQFAESAMAVKRVVLQHF----SMRYDYMKERPNIYQPSQAYMDAYSDENYNPK MNK2_Mmus_MNK -CAKDLTSFAAEAIAMNRQLAQCE----E------------------------------- MNK1_Mmus_MNK -STMDLTLFAAEAIALNRQLSQHE----E------------------------------- MAPKAPK5_Mmus_MK5 AVVAGIQQAHAEQLANMRIQDLKVSL---------------------------------- MAPKAPK3_Mmus_MK2 DHWDDVKEEMTSALATMRVDYDQVKI---------------------------------- MAPKAPK2_Mmus_MK2 ERWEDVKEEMTSALATMRVDYEQIKI---------------------------------- R166.5_Cele_MNK DSARDVQQMSEHFNLMNRLADTRLSARFD------------------------------- K08F8.1_Cele_MK2 PRLHSIQEEVGRAMEIMRMGTDQVYI---------------------------------- C44C8.6_Cele_MK2 EQWTDMQDEMEATLASMRVGPENIQI---------------------------------- MAPKAPK2_Spur_MK2 NQWADIQDEMTNALATMRVDYDQIKI---------------------------------- MAPKAPK5a_Spur_MK2 ------------------------------------------------------------ MAPKAPK5b_Spur_MK5 NMLDDAKQIHSEQLTAMRIPDKKVML---------------------------------- Mnk_Spur_MNK -SAKDLSQFAADAVACNRLVAQKE----E------------------------------- AqueK073_Aque_MK2 ELWPDIQDEMSHALATMRVADEPSKI---------------------------------- AqueK074_Aque_MK5 DALVEVQGAHAKLLQNFRRDDTGFYL---------------------------------- AqueK075_Aque_MNK SITDELSQVAASCLKCNRRLSTHF----E------------------------------- MNK2_Hsap_MNK ------------------------------------------------------------ MNK1_Hsap_MNK ------------------------------------------------------------ MAPKAPK5_Hsap_MK5 ------------------------------------------------------------ MAPKAPK3_Hsap_MK2 ------------------------------------------------------------ MAPKAPK2_Hsap_MK2 ------------------------------------------------------------ MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------ Lk6_Dmel_MNK PPGHYTRNRSQRNPASSLCGYGGRMSSMHGQRANSRRSSRNASRNASAIYPNSGGFKTLN MNK2_Mmus_MNK ------------------------------------------------------------ MNK1_Mmus_MNK ------------------------------------------------------------ MAPKAPK5_Mmus_MK5 ------------------------------------------------------------ MAPKAPK3_Mmus_MK2 ------------------------------------------------------------ MAPKAPK2_Mmus_MK2 ------------------------------------------------------------ R166.5_Cele_MNK ------------------------------------------------------------ K08F8.1_Cele_MK2 ------------------------------------------------------------ C44C8.6_Cele_MK2 ------------------------------------------------------------ MAPKAPK2_Spur_MK2 ------------------------------------------------------------ MAPKAPK5a_Spur_MK2 ------------------------------------------------------------ MAPKAPK5b_Spur_MK5 ------------------------------------------------------------ Mnk_Spur_MNK ------------------------------------------------------------ AqueK073_Aque_MK2 ------------------------------------------------------------ AqueK074_Aque_MK5 ------------------------------------------------------------ AqueK075_Aque_MNK ------------------------------------------------------------ MNK2_Hsap_MNK ------------------------------------------------------------ MNK1_Hsap_MNK ------------------------------------------------------------ MAPKAPK5_Hsap_MK5 ------------------------------------------------------------ MAPKAPK3_Hsap_MK2 ------------------------------------------------------------ MAPKAPK2_Hsap_MK2 ------------------------------------------------------------ MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------ Lk6_Dmel_MNK VHEEDDDDEGLEAFGHIDDDDEWSRSRREYQQQCETLGEDRFRRQSGSEGDEVEDDEDGE MNK2_Mmus_MNK ------------------------------------------------------------ MNK1_Mmus_MNK ------------------------------------------------------------ MAPKAPK5_Mmus_MK5 ------------------------------------------------------------ MAPKAPK3_Mmus_MK2 ------------------------------------------------------------ MAPKAPK2_Mmus_MK2 ------------------------------------------------------------ R166.5_Cele_MNK ------------------------------------------------------------ K08F8.1_Cele_MK2 ------------------------------------------------------------ C44C8.6_Cele_MK2 ------------------------------------------------------------ MAPKAPK2_Spur_MK2 ------------------------------------------------------------ MAPKAPK5a_Spur_MK2 ------------------------------------------------------------ MAPKAPK5b_Spur_MK5 ------------------------------------------------------------ Mnk_Spur_MNK ------------------------------------------------------------ AqueK073_Aque_MK2 ------------------------------------------------------------ AqueK074_Aque_MK5 ------------------------------------------------------------ AqueK075_Aque_MNK ------------------------------------------------------------ MNK2_Hsap_MNK -----------DL-AEE----------------------------E-------------- MNK1_Hsap_MNK -----------NELAEE----------------------------P-------------- MAPKAPK5_Hsap_MK5 ------------------------------------------------------------ MAPKAPK3_Hsap_MK2 ------------------------------------------------------------ MAPKAPK2_Hsap_MK2 ------------------------------------------------------------ MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------ Lk6_Dmel_MNK NEDYQHYKHYWRELDEEEGDDYLYEQQQRVDDKFGEEEFEDEPKEETQADNLKLSKAYVE MNK2_Mmus_MNK -----------DA-GQ-------------------------------------------- MNK1_Mmus_MNK -----------NELAEE----------------------------Q-------------- MAPKAPK5_Mmus_MK5 ------------------------------------------------------------ MAPKAPK3_Mmus_MK2 ------------------------------------------------------------ MAPKAPK2_Mmus_MK2 ------------------------------------------------------------ R166.5_Cele_MNK -----------NKMTMS----------------------------EC------------- K08F8.1_Cele_MK2 ------------------------------------------------------------ C44C8.6_Cele_MK2 ------------------------------------------------------------ MAPKAPK2_Spur_MK2 ------------------------------------------------------------ MAPKAPK5a_Spur_MK2 ------------------------------------------------------------ MAPKAPK5b_Spur_MK5 ------------------------------------------------------------ Mnk_Spur_MNK -----------DEIQEE----------------------------V-------------- AqueK073_Aque_MK2 ------------------------------------------------------------ AqueK074_Aque_MK5 ------------------------------------------------------------ AqueK075_Aque_MNK -----------KSFK--------------------------------------------- MNK2_Hsap_MNK ---------------------------------------AAGQ------GQP-------- MNK1_Hsap_MNK ---------------------------------------E-------------------- MAPKAPK5_Hsap_MK5 ------------------------------------------------------------ MAPKAPK3_Hsap_MK2 ------------------------------------------------------------ MAPKAPK2_Hsap_MK2 ------------------------------------------------------------ MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------ Lk6_Dmel_MNK QVGETNVEKSKPQDDNGGYIREDLIMDNMDMKKNTQQSEFAKLTIMRNDAQTEE------ MNK2_Mmus_MNK -------------------------------------------------DQP-------- MNK1_Mmus_MNK ---------------------------------------E-------------------- MAPKAPK5_Mmus_MK5 ------------------------------------------------------------ MAPKAPK3_Mmus_MK2 ------------------------------------------------------------ MAPKAPK2_Mmus_MK2 ------------------------------------------------------------ R166.5_Cele_MNK ---------------------------------------GSDLGTATIHG--DGSFLSMG K08F8.1_Cele_MK2 ------------------------------------------------------------ C44C8.6_Cele_MK2 ------------------------------------------------------------ MAPKAPK2_Spur_MK2 ------------------------------------------------------------ MAPKAPK5a_Spur_MK2 ------------------------------------------------------------ MAPKAPK5b_Spur_MK5 ------------------------------------------------------------ Mnk_Spur_MNK ---------------------------------------IEEDVDTEDDGGI-------- AqueK073_Aque_MK2 ------------------------------------------------------------ AqueK074_Aque_MK5 ------------------------------------------------------------ AqueK075_Aque_MNK ------------------------------------------------------------ MNK2_Hsap_MNK ------------------------------------------------------------ MNK1_Hsap_MNK ------------------------------------------------------------ MAPKAPK5_Hsap_MK5 ------------------------------------------------------------ MAPKAPK3_Hsap_MK2 ------------------------------------------------------------ MAPKAPK2_Hsap_MK2 ------------------------------------------------------------ MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------ Lk6_Dmel_MNK -NKIMQQQ---DEEKKEEKQQDDVDGAKKQGPSSDISATTITDNNKLQTPVMTTTHINNW MNK2_Mmus_MNK ------------------------------------------------------------ MNK1_Mmus_MNK ------------------------------------------------------------ MAPKAPK5_Mmus_MK5 ------------------------------------------------------------ MAPKAPK3_Mmus_MK2 ------------------------------------------------------------ MAPKAPK2_Mmus_MK2 ------------------------------------------------------------ R166.5_Cele_MNK GEPFGTFPRKKSVGIAIEKSR----SGEF-------------------TP---------- K08F8.1_Cele_MK2 ------------------------------------------------------------ C44C8.6_Cele_MK2 ------------------------------------------------------------ MAPKAPK2_Spur_MK2 ------------------------------------------------------------ MAPKAPK5a_Spur_MK2 ------------------------------------------------------------ MAPKAPK5b_Spur_MK5 ------------------------------------------------------------ Mnk_Spur_MNK ------------------------------------------------------------ AqueK073_Aque_MK2 ------------------------------------------------------------ AqueK074_Aque_MK5 ------------------------------------------------------------ AqueK075_Aque_MNK ------------------------------------------------------------ MNK2_Hsap_MNK ----------V------------------------------------------------- MNK1_Hsap_MNK ------------------------------------------------------------ MAPKAPK5_Hsap_MK5 ------------------------------------------------------------ MAPKAPK3_Hsap_MK2 ------------------------------------------------------------ MAPKAPK2_Hsap_MK2 ------------------------------------------------------------ MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------ Lk6_Dmel_MNK QTGDAIEDDDVKLLDSISDLNEKLPEIYETANIVVNSAAVPAASTPAASATRPPTDNPEE MNK2_Mmus_MNK ----------V------------------------------------------------- MNK1_Mmus_MNK ------------------------------------------------------------ MAPKAPK5_Mmus_MK5 ------------------------------------------------------------ MAPKAPK3_Mmus_MK2 ------------------------------------------------------------ MAPKAPK2_Mmus_MK2 ------------------------------------------------------------ R166.5_Cele_MNK ----------P------------------------------------------------- K08F8.1_Cele_MK2 ------------------------------------------------------------ C44C8.6_Cele_MK2 ------------------------------------------------------------ MAPKAPK2_Spur_MK2 ------------------------------------------------------------ MAPKAPK5a_Spur_MK2 ------------------------------------------------------------ MAPKAPK5b_Spur_MK5 ------------------------------------------------------------ Mnk_Spur_MNK ----------C------------------------------------------------- AqueK073_Aque_MK2 ------------------------------------------------------------ AqueK074_Aque_MK5 ------------------------------------------------------------ AqueK075_Aque_MNK ------------------------------------------------------------ MNK2_Hsap_MNK -------------------------------LVR-------------------------- MNK1_Hsap_MNK -------------------------------ALA-------------------------- MAPKAPK5_Hsap_MK5 ------------------------------------------------------------ MAPKAPK3_Hsap_MK2 ------------------------------------------------------------ MAPKAPK2_Hsap_MK2 ------------------------------------------------------------ MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------ Lk6_Dmel_MNK DDSNVTKPTTTAEGTTMQTTFGMSAEEEKPVALSHTAGHHSKTGRTVNFAPDAYQNDEDA MNK2_Mmus_MNK -------------------------------VIR-------------------------- MNK1_Mmus_MNK -------------------------------ALA-------------------------- MAPKAPK5_Mmus_MK5 ------------------------------------------------------------ MAPKAPK3_Mmus_MK2 ------------------------------------------------------------ MAPKAPK2_Mmus_MK2 ------------------------------------------------------------ R166.5_Cele_MNK -------------------------------ISR-------------------------- K08F8.1_Cele_MK2 ------------------------------------------------------------ C44C8.6_Cele_MK2 ------------------------------------------------------------ MAPKAPK2_Spur_MK2 ------------------------------------------------------------ MAPKAPK5a_Spur_MK2 ------------------------------------------------------------ MAPKAPK5b_Spur_MK5 ------------------------------------------------------------ Mnk_Spur_MNK -------------------------------IIR-------------------------- AqueK073_Aque_MK2 ------------------------------------------------------------ AqueK074_Aque_MK5 ------------------------------------------------------------ AqueK075_Aque_MNK ------------------------------------------------------------ MNK2_Hsap_MNK ------------------------------------------------------------ MNK1_Hsap_MNK ------------------------------------------------------------ MAPKAPK5_Hsap_MK5 ------------------------------------------------------------ MAPKAPK3_Hsap_MK2 ------------------------------------------------------------ MAPKAPK2_Hsap_MK2 ------------------------------------------------------------ MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------ Lk6_Dmel_MNK DIDEDDDYDDEENLHEHSKQQLPSNAYTRKQRQQHQRYIVPRYQLADQVPQRQHTENWRY MNK2_Mmus_MNK ------------------------------------------------------------ MNK1_Mmus_MNK ------------------------------------------------------------ MAPKAPK5_Mmus_MK5 ------------------------------------------------------------ MAPKAPK3_Mmus_MK2 ------------------------------------------------------------ MAPKAPK2_Mmus_MK2 ------------------------------------------------------------ R166.5_Cele_MNK ------------------------------------------------------------ K08F8.1_Cele_MK2 ------------------------------------------------------------ C44C8.6_Cele_MK2 ------------------------------------------------------------ MAPKAPK2_Spur_MK2 ------------------------------------------------------------ MAPKAPK5a_Spur_MK2 ------------------------------------------------------------ MAPKAPK5b_Spur_MK5 ------------------------------------------------------------ Mnk_Spur_MNK -----------------------------------------PSG---------------- AqueK073_Aque_MK2 ------------------------------------------------------------ AqueK074_Aque_MK5 ------------------------------------------------------------ AqueK075_Aque_MNK ------------------------------------------------------------ MNK2_Hsap_MNK ------------------------------------------------------------ MNK1_Hsap_MNK ------------------------------------------------------------ MAPKAPK5_Hsap_MK5 ------------------------------------------------------------ MAPKAPK3_Hsap_MK2 ------------------------------------------------------------ MAPKAPK2_Hsap_MK2 ------------------------------------------------------------ MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------ Lk6_Dmel_MNK RTHHSQEQQPTADYRKYRPPFSTGGGGGHHGNQQRNYLGSFSHSGGAAGYKIAPMPPPMQ MNK2_Mmus_MNK ------------------------------------------------------------ MNK1_Mmus_MNK ------------------------------------------------------------ MAPKAPK5_Mmus_MK5 ------------------------------------------------------------ MAPKAPK3_Mmus_MK2 ------------------------------------------------------------ MAPKAPK2_Mmus_MK2 ------------------------------------------------------------ R166.5_Cele_MNK ------------------------------------------------------------ K08F8.1_Cele_MK2 ------------------------------------------------------------ C44C8.6_Cele_MK2 ------------------------------------------------------------ MAPKAPK2_Spur_MK2 ------------------------------------------------------------ MAPKAPK5a_Spur_MK2 ------------------------------------------------------------ MAPKAPK5b_Spur_MK5 ------------------------------------------------------------ Mnk_Spur_MNK ------------------------------------------------------------ AqueK073_Aque_MK2 ------------------------------------------------------------ AqueK074_Aque_MK5 ------------------------------------------------------------ AqueK075_Aque_MNK ------------------------------------------------------------ MNK2_Hsap_MNK ------------------------------------------------------------ MNK1_Hsap_MNK ------------------------------------------------------------ MAPKAPK5_Hsap_MK5 ------------------------------------------------------------ MAPKAPK3_Hsap_MK2 ------------------------------------------------------------ MAPKAPK2_Hsap_MK2 ------------------------------------------------------------ MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------ Lk6_Dmel_MNK PPPRHNSAGSSGSGSGSGGSPPSDEQSAIRNWRQDCVYARSCGMNQGPEQQRHNRSSGQR MNK2_Mmus_MNK ------------------------------------------------------------ MNK1_Mmus_MNK ------------------------------------------------------------ MAPKAPK5_Mmus_MK5 ------------------------------------------------------------ MAPKAPK3_Mmus_MK2 ------------------------------------------------------------ MAPKAPK2_Mmus_MK2 ------------------------------------------------------------ R166.5_Cele_MNK ------------------------------------------------------------ K08F8.1_Cele_MK2 ------------------------------------------------------------ C44C8.6_Cele_MK2 ------------------------------------------------------------ MAPKAPK2_Spur_MK2 ------------------------------------------------------------ MAPKAPK5a_Spur_MK2 ------------------------------------------------------------ MAPKAPK5b_Spur_MK5 ------------------------------------------------------------ Mnk_Spur_MNK ------------------------------------------Q----------------- AqueK073_Aque_MK2 ------------------------------------------------------------ AqueK074_Aque_MK5 ------------------------------------------------------------ AqueK075_Aque_MNK ------------------------------------------------------------ MNK2_Hsap_MNK ----------------------A-TSRCLQLSPPS--------QSKLAQRRQRASLSS-- MNK1_Hsap_MNK ----------------------D-GLCSMKLSPPC--------KSRLARRRALAQAGR-- MAPKAPK5_Hsap_MK5 ----------------------------KPLHSVN--------NPILRKRKLLGTKPKDS MAPKAPK3_Hsap_MK2 ----------------------------KDLKTSN--------NRLLNKRRKKQAGSSSA MAPKAPK2_Hsap_MK2 ----------------------------KKIEDAS--------NPLLLKRRKKARALEA- MAPk-Ak2_Dmel_MK2 ----------------------------KALDKSN--------NPLLTKRRKKIEEMELY Lk6_Dmel_MNK VQQQPRIGSGRFAHLQAAQLMDELPDMRIGLSPPS--------ESVLLQRRLRQQQRA-- MNK2_Mmus_MNK ----------------------A-TSRCLQLSPPS--------QSKLAQRRQRASLSA-- MNK1_Mmus_MNK ----------------------E-GLCSMKLSPPS--------KSRLARRRALAQAGR-- MAPKAPK5_Mmus_MK5 ----------------------------KPLHSVN--------NPILRKRKLLGTKPKDG MAPKAPK3_Mmus_MK2 ----------------------------KDLKTSN--------NRLLNKRRKKQAGSSSA MAPKAPK2_Mmus_MK2 ----------------------------KKIEDAS--------NPLLLKRRKKARAVED- R166.5_Cele_MNK ----------------------A----SPTTPPPSMLNLSEDLTDSPVKRRSADDSGT-- K08F8.1_Cele_MK2 ----------------------------KNPTASC--------NNLFERRRAVHLS---- C44C8.6_Cele_MK2 ----------------------------KSLGDSN--------NKLLAKRRKGGASPKDD MAPKAPK2_Spur_MK2 ----------------------------KEVNVST--------NPLLAKRRKKELA---- MAPKAPK5a_Spur_MK2 ------------------------------------------------------------ MAPKAPK5b_Spur_MK5 ----------------------------KPVAKAN--------NPIVRKRILTRGQSIDN Mnk_Spur_MNK -------------------LNNG-GLNNFGLSPPG--------QSALAKRRAAMH-SQ-- AqueK073_Aque_MK2 ----------------------------KKVADAN--------NPILARRAKKN------ AqueK074_Aque_MK5 ----------------------------KPLGQAK--------NPVLASRMKKQEEKKES AqueK075_Aque_MNK ------------------------------LSPPG--------SSELALRRGG------- MNK2_Hsap_MNK ------------------------------------------------------------ MNK1_Hsap_MNK ------------------------------------------------------------ MAPKAPK5_Hsap_MK5 VYIHDHENGA--EDSNVALEKLRDVIAQCILPQAGKGENEDEK-----LNEVMQEAWKYN MAPKAPK3_Hsap_MK2 ------------------------------------------------------------ MAPKAPK2_Hsap_MK2 ------------------------------------------------------------ MAPk-Ak2_Dmel_MK2 ------------------------------------------------------------ Lk6_Dmel_MNK ------------------------------------------------------------ MNK2_Mmus_MNK ------------------------------------------------------------ MNK1_Mmus_MNK ------------------------------------------------------------ MAPKAPK5_Mmus_MK5 IYIHDHENGT--EDSNVALEKLRDVIAQCILPQAGKGENEDEK-----LNEVMQEAWKYN MAPKAPK3_Mmus_MK2 ------------------------------------------------------------ MAPKAPK2_Mmus_MK2 ------------------------------------------------------------ R166.5_Cele_MNK ---------------------------FSLFSPAS--SNGDDSICSPPMVFVDMPSIQLF K08F8.1_Cele_MK2 ------------------------------------------------------------ C44C8.6_Cele_MK2 PMDDIK----EEE-----------------------K----------------------- MAPKAPK2_Spur_MK2 ------------------------------------------------------------ MAPKAPK5a_Spur_MK2 ------------------------------------------------------------ MAPKAPK5b_Spur_MK5 KIGEEQPPKKQNRENSEGVTCLRNIIAHCIVPPK--DANGEDA-----LCELMKRACQYN Mnk_Spur_MNK ------------------------------------------------------------ AqueK073_Aque_MK2 ------------------------------------------------------------ AqueK074_Aque_MK5 GGAG-NESEP---SSSKAVQSLKSLMDVCNMPPPPPSLSSESSLSSSFLSESVKNALVLN AqueK075_Aque_MNK ------------------------------------------------------------ MNK2_Hsap_MNK ---------------------------------APVV------LVGDHA MNK1_Hsap_MNK ---------------------------------GEDR------SPPTAL MAPKAPK5_Hsap_MK5 RECKLLRDTLQSFSWNGRGFTDKVDRLKLAEIVKQVIE--EQTTSHESQ MAPKAPK3_Hsap_MK2 ------------------------------------------SQGCNNQ MAPKAPK2_Hsap_MK2 --------------------------------------------AALAH MAPk-Ak2_Dmel_MK2 ------------------------------------------MANATRN Lk6_Dmel_MNK ---------------------------------NDLSE--YCEPATASG MNK2_Mmus_MNK ---------------------------------TPVV------LVGDRA MNK1_Mmus_MNK ---------------------------------SRDAN--PC-LTPAGL MAPKAPK5_Mmus_MK5 RECKLLRDALQSFSWNGRGFTDKVDRLKLAEVVKQVIE--EQTLPHEPQ MAPKAPK3_Mmus_MK2 ------------------------------------------SQGCNNQ MAPKAPK2_Mmus_MK2 --------------------------------------------AALAH R166.5_Cele_MNK GTGALLTSVQMTPRHTTEDDASLKSFEDE----QENANPIHRIETQVNV K08F8.1_Cele_MK2 -------------------------------------------IPRVYC C44C8.6_Cele_MK2 ----------------------------------------DDEEEKMIS MAPKAPK2_Spur_MK2 ---------------------------------------------MQAE MAPKAPK5a_Spur_MK2 ----------------------------------------AQLEYKLHF MAPKAPK5b_Spur_MK5 RDCPSLDKALNNLSWNGEQFCDKVDRSELALLLKDIV---DQKERHEKC Mnk_Spur_MNK ---------------------------------GRDQ------CITIQA AqueK073_Aque_MK2 ----------------------------------------------SGK AqueK074_Aque_MK5 EHNASLLKALEQESWNGNEFIHQVNCKRLASSLQ-------ELIEQLEP AqueK075_Aque_MNK --------------------------------------------DHKFP