CLUSTAL W (1.83) multiple sequence alignment SgK110_Hsap MERRASET------P--E-DGD-------------------------------------- SgK069_Hsap MPGKQSEE-------GPA-EAG-----------------------------------ASE SBK_Hsap MSVGCPEP-------EPP-----------------------------------RSLTCCG CG11221_Dmel MGTIEKRSFSFRLRRSFG-DGGS--TNSRNSNNNS---STCTNHNNQKRCSTPLTPTSTS CG4945_Dmel MSKKPR------------------------------------------------------ C01C4.3_Cele MTPEKTKE------VFQMFKGAPTRRKSENAHSHRVVLNQLQNHPPRNATQSPQRQPRTS SBK_Mmus MSVGCPEP-------EPL-----------------------------------HSLPCCG SgK069_Mmus MPGKQSED-------KPM-EVS-----------------------------------TVE SgK110_Mmus MERRVLET------T--E-DGD-------------------------------------- NKF1_Spur MAQRKLSE------STGG-SGG-------------------------------------- * SgK110_Hsap --------------------------------------------PEED-TATA------- SgK069_Hsap DSEEEGLGGLTLEEL----------------------Q------QGQE-AARA------- SBK_Hsap PGTAPG--------------------------------------PGAG-VPLL------- CG11221_Dmel TGRLEV--------------------------------------PGAASVSRRSSIYKKP CG4945_Dmel ------------------------------------------------------------ C01C4.3_Cele ESSMDF-PRSALRRNSTDTHVFANRTHNHRDINVPACSSEEDRVSTAR-RNSL------- SBK_Mmus PGAAPV--------------------------------------PGAG-VPLL------- SgK069_Mmus DGGDEGLGGLTVEEL----------------------Q------QGQE-AALA------- SgK110_Mmus --------------------------------------------TEED-TAMA------- NKF1_Spur --------------------------------------------PDSG------------ SgK110_Hsap --L--QRLVELTTSRVTPVRSLRDQYHLIRKLGSGSYGRVLLAQPHQGGPAVALKLLRRD SgK069_Hsap --L--EDMMTLSAQ-TLVRAEVDELYEEVRPLGQGCYGRVLLVTHRQKGTPLALKQLPKP SBK_Hsap --T--EDMQALTLR-TLAASDVTKHYELVRELGKGTYGKVDLVVYKGTGTKMALKFVNKS CG11221_Dmel DKNDGGQIHLIPDV-ELPLMTFADQYNIEKTLAEGCFAKILLCRHRPTNTLVVLKAVHAE CG4945_Dmel -----GNIHKIREF-ELEKIQLVDEFDIIQIVGEGWFGKILLVEHRGSQTEMVLKAVPKP C01C4.3_Cele --F--VKRGSVTME-PIKKVDLEEVYTVNKQLGTGRFGFIKLAEHKQSKQRIAIKFFPRP SBK_Mmus --T--EDMQALTLR-TLAASDVTKHYELVRELGKGTYGKVDLVAYKGTGTKMALKFVNKS SgK069_Mmus --L--EDMMALSAQ-TLVQTEVEELYEEVRPLGQGRFGRVLLVTHRQKGTPLALKQLPKQ SgK110_Mmus --L--QRLVELTASRVTSVRSLCVQYRLIRKLGSGSYGRVLLAQPRQGGQTVALKLLRRD NKF1_Spur -------------T-PVSPFPGSQRYTPIGVLKEGNYGKIELIVDKRSGVRYALKQIKKN : : * :. : * : .:* . SgK110_Hsap LVLRSTFLREFCVGRCVSAHPGLLQTLAGPLQTPR--YFAFAQEYAPCGDLSGMLQ--E- SgK069_Hsap RTSLRGFLYEFCVGLSLGAHSAIVTAYGIGIESAH--SYSFLTEPVLHGDLMAFIQ--PK SBK_Hsap KTKLKNFLREVSITNSLSSSPFIIKVFDVVFETED--CYVFAQEYAPAGDLFDIIP--PQ CG11221_Dmel LTTIKEFQKEFHYNYELSHHHHILSAYAVAFQTMD--YYVFAMEHAPYGDLASNIG--P- CG4945_Dmel YVTLRDFYREFHYGLHLGVHRHIVTTYDVAFETAG--FYVFTQEYAPLGDLTSNVT--D- C01C4.3_Cele QTKQADFVREYNYSFFLSPHQNIIDTYEGMFQSSDDTAYFFVQEFCPRASLREAVEATNQ SBK_Mmus KTKLKNFLREVSITNSLSSSPFIIKVFDVVFETEE--CYVFAQEYAPAGDLFDIIP--PQ SgK069_Mmus STSLRGFLYEFCVGLSLGTHSAIVTAYGIGIESAN--SYSFLTEPVLHGDLITFIQ--PK SgK110_Mmus SVLRTTFLREFCVGRCVSSHPGLLQTLGRPLQTPR--YFAFAQEFAPCGDLSGMLQ--E- NKF1_Spur NIKFKDFHREIVLSCELSVHAAVVATLPDTFESTD--AYMMLQEYAPYGDLLEAIP--PQ * * :. :: . ::: : : * ..* : SgK110_Hsap RGLPELLVKRVVAQLAGALDFLHSRGLVHADVKPDNVLVFDP-VCSRVALGDLGLTRPEG SgK069_Hsap VGLPQPAVHRCAAQLASALEYIHARGLVYRDLKPENVLVCDP-ACRRFKLTDFGHTRPRG SBK_Hsap VGLPEDTVKRCVQQLGLALDFMHGRQLVHRDIKPENVLLFDR-ECRRVKLADFGMTRRVG CG11221_Dmel NGLHENACKLISEQLSSALGFMHSKNLVHRDLKIENILVFTP-DFTRVKLCDFGATTKKG CG4945_Dmel SGVGEVYSKRVAKQLASAIDYMHSKDIVHRDIKLDNVLIYRS-DFQRIKLCDFGESFPTG C01C4.3_Cele AGIGEANTKKVFAAVLSAIEFMHDENLVHRNLKAENILIFDANDYSKVKVTDFGLTRKVD SBK_Mmus VGLPEDTVKRCVQQLGLALDFMHSRQLVHRDIKPENVLLFDR-ECRRVKLADFGMTRRVG SgK069_Mmus VGLPQPAAQRCAAQLASALEHIHSHGLVYRDLKPENVLVCDP-ACQRVKLTDFGHTRPRG SgK110_Mmus KGLPELMVKRIVAQLAGALDFLHGRGLVHADVKPDNVLVFDP-DCNRVALGDLGLTRPEG NKF1_Spur RGLDEIRVKSCLAQVAAALSFLHSKRLVHGDVKPENVLLFDK-DLTVAKLSDFSRTRRRG *: : : : *: .:* . :*: ::* :*:*: : *:. : . SgK110_Hsap SPTPAPPVP-LPTAPPELCLLLP-PDTLPLRPAVDSWGLGVLLFCAATACFPWDVALA-P SgK069_Hsap TLLRLAGPP-IPYTAPELCAPPPLPEGLPIQPALDAWALGVLLFCLLTGYFPWDRPLAEA SBK_Hsap CRVKRVSGT-IPYTAPEVCQAGR-ADGLAVDTGVDVWAFGVLIFCVLTGNFPWEAASG-A CG11221_Dmel LLVHKVKHTWTSCVPPEQLELIK-NERFQCLPVSDSWQFGILLYNILTGNPPWQSADWVK CG4945_Dmel STVERRNEW-LPYSPPEVLEIKP-EGSYKADPSHDVWQFGIVIFVCLTGCLPWQKAAS-D C01C4.3_Cele TTVKYLEYV-NNYHAAELCDTVV-NEKLVVNKSTDIWALGIIFFYCMKGKFPWQKASIM- SBK_Mmus CRVKRVSGT-IPYTAPEVCQAGR-ADGFAVDTGVDVWAFGVLIFCVLTGNFPWEAASG-A SgK069_Mmus TLLRLTGPP-IPYTAPELCAPPPLPEGLPIQPSLDAWALGVLIFCLLTGYFPWDQPLVEV SgK110_Mmus SPTPAPPVP-LPTAPPELCLLLP-PNTLPLRPAVDSWALGVLLFCAATACFPWDVALA-P NKF1_Spur SLVRKNARS-IPYSPPEVSQALE-NESFALEPSQDSWHFGVMLFCVLTGMFPWEIADSTR ..* * * :*:::: .. **: . SgK110_Hsap NPEFEAFAGWVTTKPQ--PPQPPPPWDQFAPPALALLQGLLDLDPETRSPPLAVLDFLGD SgK069_Hsap DPFYEDFLIWQASG-Q--PRDRPQPWFGLAAAADALLRGLLDPHPRRRSAVIAIREHLGR SBK_Hsap DAFFEEFVRWQRGRL----PGLPSQWRRFTEPALRMFQRLLALEPERRGPAKEVFRFLKH CG11221_Dmel DQSYANFMKYEQRKT----TKVPDNFRRFSPRLMRCFRKYLSHDPEDRCKITEVAKYMKD CG4945_Dmel DPRYVRYLAWQGGLMMMPLRRTPRLFKLLTSNAQRMFKRFFARISNRPKSLADVTKFLDD C01C4.3_Cele CKPYWEWEQWLKRKN----PALPKKFNPFSEKALKLFKKSLTPRFKDRWTAKDMRKCLAK SBK_Mmus DAFFEEFVRWQRGRL----PGLPSQWRRFTEPALRMFQRLLALEPERRGPAKEVFRFLKH SgK069_Mmus DPFFEDFLIWQASG-Q--PQDRPQPWYSLSPAADTLLWGLLDPHPRKRNPVGSIKSYLGQ SgK110_Mmus DPEFEAFAGWMTTKPQ--PPRPPAPWDQFAPPALTLLQGLLDLDPETRSPPLAVFDVLGD NKF1_Spur SSCFEEFTRWQKRKV----TVAPPAWRNFTPKLLKLCRKLLEPKAERRGSVSQIHKYIGD : : : * : :: : . : : SgK110_Hsap DWGLQGNREGPGV-----------------------LGSAVSYED--------------- SgK069_Hsap PWRQREGEAEAV------------------------------------------------ SBK_Hsap ELTSELRRR-PSHRARKPPGDRPPAAGPLRLEAPGPLKRTVLTESGSGSRPAPPAVGSVP CG11221_Dmel RWVECRISTSKSATLISPTNHDQDSC---------------------------------- CG4945_Dmel RWLAKTAQKEMAEY---ETDELCPSM---------------------------------- C01C4.3_Cele EKLLKS------------------------------------------------------ SBK_Mmus ELTSELRRR-PSHRARKPPGDRLP--GSLRLEAPGPLKRTVLTESGSGSRPSPPSVGPV- SgK069_Mmus PWKQREGEAEEL------------------------------------------------ SgK110_Mmus NWGLQGSGEGSGS-----------------------LGV-IPYKDGE------------- NKF1_Spur SWLKQPTSSSPPSRAGTGA-------AAAK---RSPLGQNITS----------------- SgK110_Hsap ---------------REEG--GSSLEEWTDEGDDS-KS---------------------- SgK069_Hsap ------------------------------------------------------------ SBK_Hsap LPVPVPVPVPVPVPVPEPGLAPQGPPGRTDGRADKSKG---------------------- CG11221_Dmel -------------------IYLNQREGRLSGDENKLRF-------KRMMSTYGLDIPIDQ CG4945_Dmel -------------------YSF-HSS---PDEKNKL---------LYTLADCGIETNVDR C01C4.3_Cele ------------------------------------------------------------ SBK_Mmus ----VPVPVPVPVPVPEAGLAPPAPPGRTDGRTDKSKG---------------------- SgK069_Mmus ---------------------------ATELREDGWRG---------------------- SgK110_Mmus ---------------EEEG--GSSLEEWTDEEEDEIKD---------------------- NKF1_Spur ---------------------NAKEDGEGNGSNDSNNNKTCMDELRDKLEAHGVVTRTNK SgK110_Hsap ------------------------------------------------------------ SgK069_Hsap ------------------------------------------------------------ SBK_Hsap ------------------------------------------------------------ CG11221_Dmel AMVRRRVWDWLST----------------------------------------------- CG4945_Dmel QQKKNRIKDWIESSIITEEDEEENEETNSASPSSSVSREPLPGHISSLRKPTSPAESAKE C01C4.3_Cele ------------------------------------------------------------ SBK_Mmus ------------------------------------------------------------ SgK069_Mmus ------------------------------------------------------------ SgK110_Mmus ------------------------------------------------------------ NKF1_Spur DLRRQRTADWV------------------------------------------------- SgK110_Hsap ------------------------------------------------------------ SgK069_Hsap ------------------------------------------------------------ SBK_Hsap ------------------------------------------------------------ CG11221_Dmel --------CDANF----------------------------------------------- CG4945_Dmel INSTLKDATQKHFDPRTGALQQGPSEMGQVAMAYSKSASPASNYSTTASTLNNADSLMTL C01C4.3_Cele ------------------------------------------------------------ SBK_Mmus ------------------------------------------------------------ SgK069_Mmus ------------------------------------------------------------ SgK110_Mmus ------------------------------------------------------------ NKF1_Spur ------------------------------------------------------------ SgK110_Hsap ------------------------------------------------------------ SgK069_Hsap ------------------------------------------------------------ SBK_Hsap ------------------------------------------------------------ CG11221_Dmel ------------------------------------------------------------ CG4945_Dmel GSRQDLLASNLTMYTSMETELNRLGEADPRLNQRTQSNNPLLTTFDVNTNPAAKNSIGVG C01C4.3_Cele ------------------------------------------------------------ SBK_Mmus ------------------------------------------------------------ SgK069_Mmus ------------------------------------------------------------ SgK110_Mmus ------------------------------------------------------------ NKF1_Spur ------------------------------------------------------------ SgK110_Hsap -------------------------------------------G-GRTGTDGGAP SgK069_Hsap ----------------------------------------------GAVEEEAGQ SBK_Hsap -------------------------------------------QVVLATAIEICV CG11221_Dmel -----------------------------------------DPDVESLHALDLLQ CG4945_Dmel TRGSSRSILKSSIATAAYPALGAFNHGQSHSLQQLNQHLQTSTGLTPSKSSFFRR C01C4.3_Cele -----------------------------------------------VKVAVPYY SBK_Mmus -------------------------------------------QVVLATAIEICV SgK069_Mmus -------------------------------------------GQEAAKGEQPAC SgK110_Mmus -------------------------------------------S-GGMEADNRAS NKF1_Spur ------------RE-------------------------------TCVNPLVDPP