CLUSTAL W (1.83) multiple sequence alignment PINK1_Hsap MAVRQALGRG------LQLGRALLLRFTGKPGR---------------AYGLGRPGPAAG CG4523_Dmel MSVRLLTVRL------IKHGRYILRSYCKRDIHA--NILDQNQLKTRSKRGFPLPSTAAN PINK1_Mmus MAVRQALGRG------LQLGRALLLRFAPKPGP---------------LFGWGKPGPAAA EEED8.9_Cele MSMKRFGKAA------YRIANELVAKGGRLPIFQRF----LPRIFPA-TYNLGVHV---- Pink1_Spur MVLQSADERYELGSTNYDYGRSYDRHYS-RDSR--DGYRDENSMSPS-AYREGRSRERTS AqueK184_Aque MDLLLADALA------AGMARQ--AAEANRPP---------------PDNFFIIPPDAQA * : .. PINK1_Hsap CVRG---------------ERPGWAA-------------GP--------GAE------PR CG4523_Dmel VLRTTP--QQAAKS--VVNVVPRTIN-------------SPSGSPFNGSGSSPTSSSGIF PINK1_Mmus WGRG---------------ERPGQVV-------------SP--------GAQ------PR EEED8.9_Cele VLKKA--------------PFPR---------------------------------QNAL Pink1_Spur YNRNYY--SQHSRG--NSGDTPYTQDQSETYFKENFTSSRSDGDGFSDSGSRKSRTKANQ AqueK184_Aque WRKLYSTCKEENMVICVEVTDDSHPP-------------SR--------RMQ------PH : PINK1_Hsap RVGLGLP-NRLRFFRQSVAGLA-------------------------------------- CG4523_Dmel RVGQH---ARKLFIDNILSRVT-------------------------------------- PINK1_Mmus PVGLPLP-DRYRFFRQSVAGLA-------------------------------------- EEED8.9_Cele RIARLVT-RHGRVFRPFSSVII-------------------------------------- Pink1_Spur RTGSGTT-NHSHSPRSVRSRSF-------------------------------------- AqueK184_Aque IVNLAREVPQIPFFRAKI-GLGRTYDELRQDLGGIRFTPSVVILFFDDDGVRIKKAEGEE : PINK1_Hsap ------------------------ARLQRQFVVR-----AWGCAGPCGRAV-FLAFGLGL CG4523_Dmel ------------------------TTYSEDLRQRATRKLFFGDSAPFFALI-GVSLASGS PINK1_Mmus ------------------------ARIQRQFMVR-----ARGGAGPCGRAV-FLAFGLGL EEED8.9_Cele ------------------------ERHRFQNQND------------------------WR Pink1_Spur ------------------------SRSRSRSRSR-----S-------------------- AqueK184_Aque EIKMALRIGAFEKIIQDFIDQRMKLKLAEKFAEQLA----GAMASDIARKRREAALEYE- PINK1_Hsap GLIE-EKQAESRRAVSA-----CQEIQAIFTQK-SKPGPDPLDTRRL------------- CG4523_Dmel GVLSKEDELEG-----V-----CWEIREAASRLQNAWNHDEISDTLD------------- PINK1_Mmus GLIE-EKQAEGRRAASA-----CQEIQAIFTQK-TKRVSDPLDTRCW------------- EEED8.9_Cele RKFQ-PIRKELPRNVDL-----VERIRQIFGNS-LRY-NEDLKSTE-------------- Pink1_Spur ------RSTDSRSSVSG-----SDN----WSRR-SQCSKDPESDRESRNTENTQSSGSSL AqueK184_Aque EKLRKE-KAEKERKEKEAREKELEEERRKRIEA-EKKA-EEAKAS-E------------- : . . : . PINK1_Hsap --------------QGFRLEEYLIGQSIGKGCSAAVY----------------------- CG4523_Dmel --------------SKFTIDDLEIGPPIAKGCAAVVY----------------------- PINK1_Mmus --------------QGFRLEDYLIGQAIGKGCNAAVY----------------------- EEED8.9_Cele --------------WPNRIDSYEFGEFLGQGCNAAVY----------------------- Pink1_Spur KYSGLCVRNLPSRSSDSSIKDGLFHEFKKYGQVTAVT-V-----QGAGDDRVGIVFFK-- AqueK184_Aque --------------QKARLKSYAVDELMRMDLNNAKIRDIKDKMDDLGLSYAGCTSREDL :.. . . . PINK1_Hsap ----EATMPTLPQNLEVTKSTGLL------------------------------PGRGPG CG4523_Dmel ----AADFKKDVASDGASLHTDAQPQATPAFAPNSWSTHEMMSPLQNMSRFVHNFG-GSV PINK1_Mmus ----EATMPTLPQHLEKAKHLGL-------------------------------IGKGPD EEED8.9_Cele ----SARLANSDAESSGNTHYGA--------------------------------GFNEV Pink1_Spur R---TEDMEKAMSASKGKLFFGCEMKLSP---------W---------------EGAADI AqueK184_Aque IKKLTANVPSLKTKMDQTDGGGGRP--STSYVPSSYSSSQR-----------H------S . . . PINK1_Hsap TSAPG-E----------------------------------------------------- CG4523_Dmel DNVFHYSQP-----SA-----------ASDFVGAQSREQDQRHHEQQQHQNQE---QEQH PINK1_Mmus VVLKG-A----------------------------------------------------- EEED8.9_Cele TNILAEI----------------------------------------------------- Pink1_Spur SVDDSEVKY-----FEKELDEFHPRATRTLFVGNLDRTIDKDELHDAFCKFGD---IV-- AqueK184_Aque SGILYSNKPTDTGPSD------NGEVIKLRRKV----EQLQGNIEEINVMRESLEDELAR PINK1_Hsap ------------------------GQERAP-------GAPAFP---------LAIKMMWN CG4523_Dmel QN--------QEPSSSAFNVTSPANSNINS-------SVDSYP---------LALKMMFN PINK1_Mmus ------------------------DGEQAP-------GTPTFP---------FAIKMMWN EEED8.9_Cele ------------------------PPVSKV-------AQKKFP---------LAIKLMFN Pink1_Spur ------------------------HIEIKK-------PQSAQP---------FAFLQFSN AqueK184_Aque KNREIAALKSR-----------GGGIGRVPLFGGGGGGGDSFTKVKELENELLETRMLYT . : : . PINK1_Hsap ISAG-----SSSEA--------ILNT---MSQELVPASR---V--ALAGEYGAVT----- CG4523_Dmel YDIQ-----SNALS--------ILRA---MYKETVPARQ---R--GM-NEAADEW----- PINK1_Mmus ISAG-----SSSEA--------ILSK---MSQELVPASR---V--ALAGEYGAVT----- EEED8.9_Cele FEHD-----RDGDAH-------LLKS---MGNELAPYPN---AAKLLNGQMGTF------ Pink1_Spur IDS-------------------------------VVKAR---K--KLDGEYVGKNKVKTY AqueK184_Aque CTLDDFEVLGVISRGKLAEGRSMMVVRAQCIKPGLPYPDRVYALKMLSGVHDTTTMT--- : . PINK1_Hsap -------YRKSKRGPKQLAPHPNIIRVLRAFTSSVP--LLPGALVDYPDVLP-SRLHPEG CG4523_Dmel -------ERLLQNQTVHLPRHPNIVCMFGFFCDEVR--NFPDGHLLYPVAQP-QRINPQG PINK1_Mmus -------YRRSRDGPKQLAPHPNIIRVFRAFTSSVP--LLPGALADYPDMLP-PHYYPEG EEED8.9_Cele --------------RPLPAKHPNVVRIQTAFIDSLK--VLPDAIERYPDALHTARWYESI Pink1_Spur FPNNHG-YWENRPNGSLRSSHPNIVLMHRAFVDDVRVPSLSSAVSLFDVALP-VRLNPMG AqueK184_Aque --NARDQHKNEYEVLSSIPPHKNIVRLFAFFYDRPKA--H------------P-KLSREN . * *:: : * . : PINK1_Hsap LGHGRTLFLVMKNYPCTLRQYL----CVNTP-SPRLAAMMLLQLLEGVDHLVQQGIAHRD CG4523_Dmel YGRNMSLYLLMKRYDHSLRGLL----DSQDL-STRNRILLLAQMLEAVNHLSRHGVAHRD PINK1_Mmus LGHGRTLFLVMKNYPCTLRQYL----EEQTP-SSRLATMMTLQLLEGVDHLVQQGIAHRD EEED8.9_Cele ASEPKTMYVVMRRYRQTLHEYV----WTRHR-NYWTGRVIIAQLLEACTYLHKHKVAQRD Pink1_Spur AGADTTMYIVMKRYRTSLRDYL----SMECDLPDHTVMVIVAQLLEAVGYLGNQGVVHRD AqueK184_Aque CSEGIALCIMMEQLSQNMEYQLKPLRQTAGP-NYSKVLGWLKDLLTGLQYLFTHYVLHRD . :: ::*.. .:. : ::* . :* : : :** PINK1_Hsap LKSDNILVELDP--DGCPWLVIADFGCCLADESIGLQLPFSSWYVDRGGNGCLMAPEVST CG4523_Dmel LKSDNVLIELQD--DAAPVLVLSDFGCCLADKVHGLRLPYVSHDVDKGGNAALMAPEIFN PINK1_Mmus LKSDNILVEWDS--DGCPWLVISDFGCCLADQHVGLRLPFNSSSVERGGNGSLMAPEVST EEED8.9_Cele MKSDNILLEYDF-DDEIPQLVVADFGCALACD--NWQVDYESDEVSLGGNAKTKAPEIAT Pink1_Spur LKSNNILVDYEEASGASPHVVIADFGCALSLRGRNLQDSVSVEDRNRQGNSALMAPEVTK AqueK184_Aque LKLENLMLSGD-------ILKIVDFGEAIKLEP-DYKIPFDR-PCSKGGNEAHLAPEILN :* :*:::. : : : *** .: . : . ** ***: . PINK1_Hsap ARPGP-RAVIDYSKADAWAVGAIAYEIFGLVNPFYGQGK----------AHLESRSYQEA CG4523_Dmel TMPGP-FAVLNYGKADLWACGALAYEIFGNRNPFYSSSGGMARERGEMTLSLRNSDYRQD PINK1_Mmus AHSGP-SAVIDYSKADTWAVGAIAYEIFGLANPFYGQGS----------AHLESRSYQEA EEED8.9_Cele AVPGK-NVKVNFEMADTWAAGGLSYEVLTRSNPFYKL--------------LDTATYQES Pink1_Spur GYHHDCLHYHDYLKADAWAVGAIIYEVCGQKNPFYSDG-------------VNSCGYEAG AqueK184_Aque QRTGR-GRVLDYTKQPVWAAGVLAYELAGYQNPFSGS--------------KDQRAYDER :: ** * : **: *** * PINK1_Hsap QLPALPESV---------PPDVRQLVRALLQREASKRPSARVAANVLHLSLWGE--HILA CG4523_Dmel QLPPMSDAC---------PPLLQQLVYNILNPNPSKRVSPDIAANVVQLFLWAPSNWLKA PINK1_Mmus QLPEMPESV---------PPEARRLVRSLLQREASKRPSARLAANVLHLSLWGE--HLLA EEED8.9_Cele ELPALPSRV---------NFVARDVIFDLLKRDPNERVKPNIAANALNLSLFRMGEDVKQ Pink1_Spur DLPQLQSQA----------VGLKIISKLLLQKDPGERPSAQVAANILHLLLWQP--SVSS AqueK184_Aque TLPRLTDTYSKTGRGQKFPPEFPNIVTSMLSFEPARRPTLSEALNKI------------- ** : . : :*. :. .* . * * : PINK1_Hsap LKNL-----------------------KL-DKMVGWLLQQSAATLLANRLT--------- CG4523_Dmel GGMP-----------------------N-SPEILQWLLSLTTKIMCEGRPQMGAGLMPVA PINK1_Mmus LKNL-----------------------KL-DKMIAWLLQQSAATLLADRLR--------- EEED8.9_Cele MMEKCGISQMTTLLAGSSKVLSQKINSRL-DKVMNLITAETIMANLAPHLI--------- Pink1_Spur LLRLCH-----------------S-QSQMDSELSAWIIKVSLMQLVQDQAEK---TLPS- AqueK184_Aque ------------------------------------------------------------ PINK1_Hsap -------EKCCVETKMKMLFLANLECETLCQAAL-LLC---------------------- CG4523_Dmel SCG---NRRAYVEYLLICSFLARARLRRIRGA---------------------------- PINK1_Mmus -------EKSCVETKLQMLFLANLECEALCQAAL-LLS---------------------- EEED8.9_Cele ---------SRAERQLRATFLSRMNREDIWRSLQYFFPAGVQLDTPATSSDCLETISSLM Pink1_Spur TRADPGIPLNPVEKGLLETFLKRVNSGHLICATQYLVKAFEPLALFAVSSLP--VGREQL AqueK184_Aque ------------------------------------------------------------ PINK1_Hsap -------------------------------------------SWRAAL CG4523_Dmel --------------------------------------LNWI--QNVVA PINK1_Mmus -------------------------------------------SWRAAP EEED8.9_Cele SSFSNDSENYEKQQKPAKNGYNNVPLLLRNVIRTDADGINGIVHRVRSK Pink1_Spur --------------------------------TDLSSNADR--IVTLQA AqueK184_Aque ---------------------------------------------TKLV