CLUSTAL W (1.83) multiple sequence alignment NRBP2_Hsap MAAPEPA-----------------------------------------------PR---- NRBP1_Hsap MSEGESQTVLSS---GSDPKVESSS----SAPG-L----------TSVSPPV--TS---- NRBP2_Mmus MAAPEPA-----------------------------------------------PR---- NRBP1_Mmus MSEGESQTVVSS---GSDPKVESSS----LAPG-L----------TSVSPPV--TS---- K10D3.5_Cele MVSSGEERTAAGKT----P----------------------------------------- NRBP_Spur MPTTGGNDERTGSP--RDSGDESEDEREILEES-PCGRWQKRRV-KNTEMPTTGGN---- Madm_Dmel MSNSQANAGISGSTVADEPIQHHPS----LAAG-P----------VSASCPAATPP---- AqueK186_Aque MPRSPPSSQQTQAPPG---GLSSSSTTAA-STGVPE-------LPVATSEPVTGVSHEEK * NRBP2_Hsap -R------------------------------------AREREREREDESEDESDILEES NRBP1_Hsap -T------------------------------------TSAASPEEEEESEDESEILEES NRBP2_Mmus -R--------------------------------------GREREREDESEDESDILEES NRBP1_Mmus -T------------------------------------TSAASPEEEEESEDESEILEES K10D3.5_Cele ---------------------------------------IGDDAASDSDADGAEEILEES NRBP_Spur -DE-----------------------------------RTGSPRDSGDESEDEREILEES Madm_Dmel -SQSTQQPPPHIVSASTADAGSSAAVGVGVVAGSEGVNLDSSPRESGDDSEDESEILEES AqueK186_Aque TKGPG---------------------------------ADEVVEDEEEEEEDDEKILEIG .: :. .*** . NRBP2_Hsap PCGRWQKRREQVNQGNMPGLQSTFLAMDTEEGVEVVWNELHFGDRKAFAAHEEKIQTVFE NRBP1_Hsap PCGRWQKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFD NRBP2_Mmus PCGRWQKRREQVNQGNMPGIQSTFLAMDTEEGVEVVWNELHFGDRKAFAAHEEKIQTMFE NRBP1_Mmus PCGRWQKRREEVNQRNVPGIDSAYLAMDTEEGVEVVWNEVQFSERKNYKLQEEKVRAVFD K10D3.5_Cele PDKRWSKRREQVKQRDVPGIDVAYLAMDNETGNEVVWNEVQFSERKNFRAQEEKINAVFD NRBP_Spur PCGRWQKRRVKVTQRDVPGIDVAYLAMDMEEGREVVWNEVQFSARRDFKAQEDILHLLLH Madm_Dmel PCGRWLKRREEVDQRDVPGIDCVHLAMDTEEGVEVVWNEVQYASLQELKSQEEKMRQVFD AqueK186_Aque HNGRWQKIN--------------------------------------------------- ** * . NRBP2_Hsap QLVLVDHPNIVKLHKYWLDTSE----ACARVIFITEYVSSGSLKQFLKKTKKN--HKAMN NRBP1_Hsap NLIQLEHLNIVKFHKYWADIKE----NKARVIFITEYMSSGSLKQFLKKTKKN--HKTMN NRBP2_Mmus QLALVDHPNIVKLHKYWLDASE----ARARVIFITEYVSSGSLKQFLKKTKKN--HKAMN NRBP1_Mmus NLIQLEHLNIVKFHKYWADVKE----NKARVIFITEYMSSGSLKQFLKKTKKN--HKTMN K10D3.5_Cele NLTQLVHTNLVKFHKYWTDSKS----EKPRIIFITEYMSSGSMSAFLQRTRKA--GSSLS NRBP_Spur HLIHLQHLLIVKLHNHCHDTMLHIDQLHIRVIFITEYMSSGSLKQFLKKIKKD--KRNIQ Madm_Dmel NLLQLDHQNIVKFHRYWTDTQQ---AERPRVVFITEYMSSGSLKQFLKRTKRN--AKRLP AqueK186_Aque ----HQHQNIVNFYDFWHDKVN----SKDRLVFITEYITSGSLAQFLKKNKRVKGTNSIS * :*::: . * *::*****::***: **:: :: : NRBP2_Hsap ARAWKRWCTQILSALSFLHACSPPIIHGNLTSDTIFIQHNGLIKIGSVWHRIFSNALRPP NRBP1_Hsap EKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGSV------------ NRBP2_Mmus ARAWKRWCTQILSALSFLHACSPPIIHGNLTSDTIFIQHNGLIKIGSVWYRIFS------ NRBP1_Mmus EKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQHNGLIKIGSV------------ K10D3.5_Cele IKAWKKWTTQILSALNYLHSSDPPIIHGNLTCNTVFIQQNGLIKIGCV------------ NRBP_Spur EKSWRRWCTQILSALSYLHSCDPPIIHGNLTTDTVFIQHNGLIKIGSV------------ Madm_Dmel LESWRRWCTQILSALSYLHSCSPPIIHGNLTCDSIFIQHNGLVKIGSV------------ AqueK186_Aque DKIWRRWCRQILSALSYLHKN--EIIHGNLSLASIFIQHNGLVKIGSV------------ . *::* ******.:** ******: ::***:***:***.* NRBP2_Hsap TALPDDLRSPIRAE----REELRNLHFF-PPEYGEVA--DG-TAVDIFSFGMCALEMAVL NRBP1_Hsap --APDTINNHVKTC----REEQKNLHFF-APEYGEVT--NVTTAVDIYSFGMCALEMAVL NRBP2_Mmus NALPDDLRSPIRAE----REELRNLHFF-PPEYGEVN--DG-TAVDIFSFGMCALEMAVL NRBP1_Mmus --APDTINNHVKTC----REEQKNLHFF-APEYGEVT--NVTTAVDIYSFGMCALEMAVL K10D3.5_Cele --APDAINHHVKTC----RENMRYMHYI-APEYEILDNTELTSAADIYSFGICSLEIAVI NRBP_Spur --APDAINNHVKTY----TEEQRNMHYI-APEYGGFK----------------------- Madm_Dmel --VPDAVHYSVRRGRERERERERGAHYFQAPEYGAAD--QLTAALDIYAFGMCALEMAAL AqueK186_Aque --SPNAIHQHVKTK---NREAAAGLHYA-APELAEGP--MR-TSADIYAFGICALEMLNL *: :. :: * *: .** NRBP2_Hsap EIQ-T--NGDT----RVTEEAIARARHSLSDPNMREFILCCLARDPARRPSAHSLLFHRV NRBP1_Hsap EIQ-G--NGES---SYVPQEAISSAIQLLEDPLQREFIQKCLQSEPARRPTARELLFHPA NRBP2_Mmus EIQ-A--NGDT----RVTEEAIARARHSLSDPNMREFILSCLARDPARRPSAHNLLFHRV NRBP1_Mmus EIQ-G--NGES---SYVPQEAISSAIQLLEDSLQREFIQKCLQSEPARRPTARELLFHPA K10D3.5_Cele GGLSGCQNGSSE--GPVTEDVIEKAIRSLEDPMQQDFIRQCLRKDPAERPSARELLFHQI NRBP_Spur ---------------------------------QMNFLKRCLD-DVQSRPTARDLLLHPV Madm_Dmel EIQ-P-SNSES---TAINEETIQRTIFSLENDLQRDLIRKCLNPQPQDRPSANDLLFHPL AqueK186_Aque ALL-G--NGETVQQGQLRSDAIQKALDQL-NPRTKQFIELCIDHDYEKRPQAHSLIKHLV ::: *: : ** *..*: * NRBP2_Hsap LFEVHSLKLLAAHCFIQ---HQYLMPENVVEEK-TKAMDLHAVLAELPRP-RRPPLQWRY NRBP1_Hsap LFEVPSLKLLAAHCIVG---HQHMIPENALEEI-TKNMDTSAVLAEIPAGPGREPVQTLY NRBP2_Mmus LFEVHSLKLLAAHCFIQ---HQYLMPENVVEEK-TKAMDLHAVLAEMPQP-HGPPMQWRY NRBP1_Mmus LFEVPSLKLLAAHCIVG---HQHMIPENALEEI-TKNMDTSAVLAEIPAGPGREPVQTLY K10D3.5_Cele LFEVHSLKLLSAHAIVD---SKKY--EDVSESA-FRIKDNETIAATSKLR----EM--AY NRBP_Spur LFEVHSLKLLAAHSFAK---NESFLQEHLSDKE-QNKVQKDDVIATIKLQGQAEEVQWRV Madm_Dmel LFEVHSLKLLTAHCLVFSPANRTMFSETAFDGLMQRYYQPDVVMAQLRLAG-GQERQYRL AqueK186_Aque LQEVFTLKLLSAYALRG---VKNL--QDIIDSY-RKSS--DTVLATVNAK-R-IQKTFTA * ** :****:*:.: . : : . : * NRBP2_Hsap SEVS--FMELDKFLEDVRNGI-YPLMNFAATRPLGLPR--VLAPPPEE------------ NRBP1_Hsap SQSP--ALELDKFLEDVRNGI-YPLTAFGLPRPQQPQQ--EEVTSPVV------------ NRBP2_Mmus SEVS--FLELDKFLEDVRNGI-YPLMNFAAARPLGLPR--VLAPPPEE------------ NRBP1_Mmus SQSP--ALELDKFLEDVRNGI-YPLTAFGLPRPQQPQQ--EEVTSPVV------------ K10D3.5_Cele CQVAAFQVDLEKFLDDVRNGI-YPLTAFAPLAHQPSTT--LRAYSNTNPSTLITTDISAP NRBP_Spur AQVP--ALELEKFLEEVRNGI-HPLTAFAMKRSYP-VK--IRPQSPET------------ Madm_Dmel ADVS-GADKLEKFVEDVKYGV-YPLITYSGKKPPNF-R--SRAASPER------------ AqueK186_Aque ADTA--QIDIEKFFDDISQDLLFEAEQIAENSPQEKDEPRRAGILTES------------ .: . .::**.::: .: . . NRBP2_Hsap -------------------------------------VQ-KAKTPTPEPFD--------- NRBP1_Hsap -------------------------------------PP-SVKTPTPEPAE--------- NRBP2_Mmus -------------------------------------AQ-KAKTPTPEPFD--------- NRBP1_Mmus -------------------------------------PP-SVKTPTPEPAE--------- K10D3.5_Cele SSTHPSANSTITAETSVNTSLPGQSSQPSGTTTNTNGPSSIGKSASPEAVDKKIGEVTST NRBP_Spur -------------------------------------QE-SVKSATPEPID--------- Madm_Dmel -------------------------------------AD-SVKSATPEPVD--------- AqueK186_Aque -------------------------------------NS-TATDRTSTNHE--------- . :. : NRBP2_Hsap -------------------------------------------SETRKVIQMQCNLERSE NRBP1_Hsap -------------------------------------------VETRKVVLMQCNIESVE NRBP2_Mmus -------------------------------------------SETRKVVQMQCNLERSE NRBP1_Mmus -------------------------------------------VETRKVVLMQCNIESVE K10D3.5_Cele ESTSKVEVEVNGANVTIGSSNGRDAGSPTPEEEGEPNGERDMRLENRHILEINVHIENE- NRBP_Spur -------------------------------------------MENRKITMMQCDIKQGK Madm_Dmel -------------------------------------------TESRRIVNMMCSVKIKE AqueK186_Aque -------------------------------------------LETRRFATCSCDVLSLE *.*:. : NRBP2_Hsap DK----ARWHLTLLLVLEDRLHRQLTYDLLPTDSAQDLASELVHYGFLHEDDRMKLAAFL NRBP1_Hsap EG----VKHHLTLLLKLEDKLNRHLSCDLMPNENIPELAAELVQLGFISEADQSRLTSLL NRBP2_Mmus DK----ARWHLTLLLVLEDRLHRQLTYDLLPTDSAQDLAAELVHYGFLHEDDRTKLAAFL NRBP1_Mmus EG----VKHHLTLLLKLEDKLNRHLSCDLMPNESIPDLAAELVQLGFISEADQSRLTSLL K10D3.5_Cele ---------EMSIVLLLEDQMHRQLTTSINKGDNPETLTENLITHGFMCQLDSEGVEKAI NRBP_Spur EGEETQTNLHLELLLRLDDTMNRHLSCEITAEESPRVLANELVQYGFISDFDKDRVAGII Madm_Dmel DS----NDITMTILLRMDDKMNRQLTCQVNENDTAADLTSELVRLGFVHLDDQDKIQVLL AqueK186_Aque DG-----KNEVCIKLQFGSKMERELRIELQEDDTPQDLVADLVQWGLLSREDAEPLVSKL : : * : . :.*.* .: :. *. :*: *:: * : : NRBP2_Hsap ESTFLKY----------------------------------------------------- NRBP1_Hsap EETLNKF--NFARN--------------------------------ST------------ NRBP2_Mmus ETTFLKY----------------------------------------------------- NRBP1_Mmus EETLNKF--NFTRN--------------------------------ST------------ K10D3.5_Cele AVAFDIRAARIAEGVQEEENETSTRESNSEAPIEHGTSSSITNSVKPIVDSVA------- NRBP_Spur EEKVNIV--V-------------------------------------------------- Madm_Dmel EETLKAG--VMSDGAGAESSGAGVTTTATMAALEQLER-------NWSISSDADKQGTAV AqueK186_Aque S----------------------------------------------------------- NRBP2_Hsap -------------------RGTQA NRBP1_Hsap --------------LNSAAVTVSS NRBP2_Mmus -------------------RGTQA NRBP1_Mmus --------------LNTATVTVSS K10D3.5_Cele ------------PSSQTPTTTTSS NRBP_Spur ---------------QSVVPAIAT Madm_Dmel MYVPQEQQNADGDVDVEHSGTTSN AqueK186_Aque --------------------TILA