CLUSTAL W (1.83) multiple sequence alignment PDHK4_Hsap_PDHK MKAARFVLRSAG----------------SL---------------------NGA------ PDHK3_Hsap_PDHK MRLFRWLLKQ-------------------------------------------------- PDHK2_Hsap_PDHK MRWVWALLKNA-----------------SL------------------------------ PDHK1_Hsap_PDHK MRLARLLRGAALA----GPGPGLRAAGFSRSFSSDSG-----------SSPASE------ PDK_Dmel_PDHK MRLFPVRFSAA-----------------SL---------------------S-M------ PDHK4_Mmus_PDHK MKAARFVMRSAS----------------SL---------------------SSA------ PDHK3_Mmus_PDHK MRLFYRLLKQ-------------------------------------------------- PDHK2_Mmus_PDHK MRWVRALLKNA-----------------SL------------------------------ PDHK1_Mmus_PDHK MRLARLLRGGTSV----RPLCAVPCASRSLASASASG-----------SGPASE------ BCKDK_Mmus_BCKDK MILTSVLGSGPRSWSSLWPLLGSSLSLRARSTSATD---------THHVELARERSKTVT BCKDK_Hsap_BCKDK MILASVLRSGPGGGLPLRPLLGPALALRARSTSATD---------THHVEMARERSKTVT YIL042C_Scer_PDHK MWKIMRSWKCGGM-RWAHR-QRPSHE--LLSQLSFD----------QHYK-I-R------ BCKDK_Spur_BCKDK MALSTMKANQL-VFK---QALNFKSASYSRSIAITSYRPQSNYSAVHDYSPAKEKSRPVV PDHK_Spur_PDHK MVRLTVRLLAM----------------------------------------A-K------ aSWK467_Cele_PDHK MRFSRKLLGPF------------------------------------------V------ pdhk-2_Cele_PDHK MRFSRKLLGPF------------------------------------------V------ CC1G_13956_Ccin_BCKDK MLLRHALRPLARR-RWYST------K--FQQP-------------------N-S------ CC1G_00337_Ccin_BCKDK MTTFMVGRRVFNL-TTTTPFLQSSLR--YSST-------------------F-N------ CC1G_15212_Ccin_PDHK MSAGFRITP--------------------------------------------------- * PDHK4_Hsap_PDHK -GLVPREVEHFSRYSPSPLSMKQLLDFGSENAC--ERTSFAFLRQELPVRL---ANILKE PDHK3_Hsap_PDHK --PVPKQIERYSRFSPSPLSIKQFLDFGRDNAC--EKTSYMFLRKELPVRL---ANTMRE PDHK2_Hsap_PDHK -AGAPKYIEHFSKFSPSPLSMKQFLDFGSSNAC--EKTSFTFLRQELPVRL---ANIMKE PDHK1_Hsap_PDHK -RGVPGQVDFYARFSPSPLSMKQFLDFGSVNAC--EKTSFMFLRQELPVRL---ANIMKE PDK_Dmel_PDHK -ASLAKMLDFYSGFNPSPLSIKQFMDFGQ-NAC--EKKSYIFLRKELPVRL---ANIMKE PDHK4_Mmus_PDHK -SLVPREVELFSRYSPSPLSMKQLLDFGSENAC--ERTSFAFLRQELPVRL---ANILKE PDHK3_Mmus_PDHK --PVPKQIERYSRFSPSPLSIKQFLDFGRDNAC--EKTSYMFLRKELPVRL---ANTMRE PDHK2_Mmus_PDHK -AGAPKYIEHFSKFSPSPLSMKQFLDFGSSNAC--EKTSFTFLRQELPVRL---ANIMKE PDHK1_Mmus_PDHK -LGVPGQVDFYARFSPSPLSMKQFLDFGSVNAC--EKTSFMFLRQELPVRL---ANIMKE BCKDK_Mmus_BCKDK SFYNQSAIDVAAEKPSVRLTPTMMLYSGRSQDGSHLLKSGRYLQQELPVRI---AHRIKG BCKDK_Hsap_BCKDK SFYNQSAIDAAAEKPSVRLTPTMMLYAGRSQDGSHLLKSARYLQQELPVRI---AHRIKG YIL042C_Scer_PDHK -SNIELLIQDYASKPIAPLNYEYFLQYRPPLTK---KEEYMLTIKTINLLLSLTCKRLNA BCKDK_Spur_BCKDK SFYNQSAIDVAAKKPSVRLTPATLLYTGKSPDGNHLLRSAQYLHKELPVRV---AHRIAE PDHK_Spur_PDHK -KNMQAQMEYYSKFSPSPLSIKQFMDFGQSKDV-DSAKSFVFLRQELPVRI---ANIMKE aSWK467_Cele_PDHK -GSLAKKLDYYSQFQPSSLTIQQYLDFGRIGT--S-ANSYTFLKNELLVRL---ANIMQE pdhk-2_Cele_PDHK -GSLAKKLDYYSQFQPSSLTIQQYLDFGRIGT--S-ANSYTFLKNELLVRL---ANIMQE CC1G_13956_Ccin_BCKDK -AEVTALLAQYGTAAPRPLNLSQLLSFGRPVTPDSVLSSVSYVLYELPRRL---ATRVRY CC1G_00337_Ccin_BCKDK -FYQNRQLEQYANREAKPLTLRQLVFFGRHLTEEKILKSANYVRSELPVRI---AHRLRD CC1G_15212_Ccin_PDHK --ALWDKIHHFASFPQTGVSLQQMVLFGQNPSQGTLLKASQFLSEELPVRL---AHRVKE : . :. : : : . : PDHK4_Hsap_PDHK IDILPTQLVNTSSVQLVKSWYIQSLMDLVEFHEKSP------------------------ PDHK3_Hsap_PDHK VNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSP------------------------ PDHK2_Hsap_PDHK INLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDP------------------------ PDHK1_Hsap_PDHK ISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKDKSA------------------------ PDK_Dmel_PDHK IALLPDNLLHTRSVSEVSSWYVKSFEDVLVYEKAEP------------------------ PDHK4_Mmus_PDHK IDILPDRLVNTPSVQLVKSWYIQSLMDLVEFHEKSP------------------------ PDHK3_Mmus_PDHK VNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSP------------------------ PDHK2_Mmus_PDHK INLLPDRVLGTPSVQLVQSWYVQSLLDIMEFLDKDP------------------------ PDHK1_Mmus_PDHK ISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKDKSA------------------------ BCKDK_Mmus_BCKDK FRSLPFIIGCNPTILHVHELYIRAFQKLTDFPPIK------------------------- BCKDK_Hsap_BCKDK FRCLPFIIGCNPTILHVHELYIRAFQKLTDFPPIK------------------------- YIL042C_Scer_PDHK IQRLPYNAVINPHIERTNSLYLKSLQTLLSIAYPYE------------------------ BCKDK_Spur_BCKDK FRGLPFIVGCNPTILHVHELYIRAFHLLSEFPSIR------------------------- PDHK_Spur_PDHK INLLPEKLLQMPSVRMVQGWYQQTFEELLEYVEKTE------------------------ aSWK467_Cele_PDHK FTLLPPKLLQMPSSKMVSNWYAESFEDLLLFEASD------------------------- pdhk-2_Cele_PDHK FTLLPPKLLQMPSSKMVSNWYAESFEDLLLFEASD------------------------- CC1G_13956_Ccin_BCKDK LESLPFIVGTNPYVAKTLKAFREGFWVLATHPPVTNL----------------------- CC1G_00337_Ccin_BCKDK LQALPYVVVTQEGVEKVYKLYWTAFEKFRTYPPITS------------------------ CC1G_15212_Ccin_PDHK LDELPHNLSDMPSIKRVKNWYAQSFEELINFPHPQLPPEIRQALITSRSDELALPESKPN . ** . : : . PDHK4_Hsap_PDHK ------------------------------------------------DDQKALSDFVDT PDHK3_Hsap_PDHK ------------------------------------------------EDPQVLDNFLQV PDHK2_Hsap_PDHK ------------------------------------------------EDHRTLSQFTDA PDHK1_Hsap_PDHK ------------------------------------------------EDAKAIYDFTDT PDK_Dmel_PDHK -------------------------------------------------THDNLQKFVAD PDHK4_Mmus_PDHK ------------------------------------------------EDQKALSEFVDT PDHK3_Mmus_PDHK ------------------------------------------------EDPRVLDNFLNV PDHK2_Mmus_PDHK ------------------------------------------------EDHRTLSQFTDA PDHK1_Mmus_PDHK ------------------------------------------------EDAKTIYEFTDT BCKDK_Mmus_BCKDK -------------------------------------------------DQADEAQYCQL BCKDK_Hsap_BCKDK -------------------------------------------------DQADEAQYCQL YIL042C_Scer_PDHK --------------------------------------------------LHNPPKIQAK BCKDK_Spur_BCKDK -------------------------------------------------DMDTERQYCKM PDHK_Spur_PDHK ------------------------------------------------EEDPVLLRYINQ aSWK467_Cele_PDHK ------------------------------------------------SSPEQVARFNDQ pdhk-2_Cele_PDHK ------------------------------------------------SSPEQVARFNDQ CC1G_13956_Ccin_BCKDK ---------------------------------------------------EENEK---- CC1G_00337_Ccin_BCKDK --------------------------------------------------IEENTKFCKF CC1G_15212_Ccin_PDHK PSLIDTIYGSSPSNGNGNGGNGFNKLRLRVPMERRYYANTSNITHWPPEVQDYNKRFTKL PDHK4_Hsap_PDHK LIKVRNRHHNVVPTMAQG------------------------------------------ PDHK3_Hsap_PDHK LIKVRNRHNDVVPTMAQG------------------------------------------ PDHK2_Hsap_PDHK LVTIRNRHNDVVPTMAQG------------------------------------------ PDHK1_Hsap_PDHK VIRIRNRHNDVIPTMAQG------------------------------------------ PDK_Dmel_PDHK LDLIRNRHNDVVQTMAQG------------------------------------------ PDHK4_Mmus_PDHK LVKVRNRHHNVVPTMAQG------------------------------------------ PDHK3_Mmus_PDHK LINIRNRHNDVVPTMAQG------------------------------------------ PDHK2_Mmus_PDHK LVTIRNRHNDVVPTMAQG------------------------------------------ PDHK1_Mmus_PDHK VIRIRNRHNDVIPTMAQG------------------------------------------ BCKDK_Mmus_BCKDK VRQLLDDHKDVVTLLAEG------------------------------------------ BCKDK_Hsap_BCKDK VRQLLDDHKDVVTLLAEG------------------------------------------ YIL042C_Scer_PDHK FTELLDDHEDAIVVLAKG------------------------------------------ BCKDK_Spur_BCKDK VKTLLDDHKDVVTHLAEG------------------------------------------ PDHK_Spur_PDHK LTTIRNRHVNVVETMAQG------------------------------------------ aSWK467_Cele_PDHK LTVVLKRHAHVVETMAEG------------------------------------------ pdhk-2_Cele_PDHK LTVVLKRHAHVVETMAEG------------------------------------------ CC1G_13956_Ccin_BCKDK ------------------FQ---------------------------------------- CC1G_00337_Ccin_BCKDK VGSLLDDHAVVIPNLSLG------------------------------------------ CC1G_15212_Ccin_PDHK LEHIKSRHDPTVTTVAQGRSFRLPAFFGVLGVFWASGLGSVPLPSLYSRSMDPFVICEEH PDHK4_Hsap_PDHK -----------------------------------------------------IIEYKDA PDHK3_Hsap_PDHK -----------------------------------------------------VIEYKEK PDHK2_Hsap_PDHK -----------------------------------------------------VLEYKDT PDHK1_Hsap_PDHK -----------------------------------------------------VIEYKES PDK_Dmel_PDHK -----------------------------------------------------VIEMKEN PDHK4_Mmus_PDHK -----------------------------------------------------ILEYKDT PDHK3_Mmus_PDHK -----------------------------------------------------VIEYKEK PDHK2_Mmus_PDHK -----------------------------------------------------VLEYKDT PDHK1_Mmus_PDHK -----------------------------------------------------VTEYKES BCKDK_Mmus_BCKDK -----------------------------------------------------LRESRKH BCKDK_Hsap_BCKDK -----------------------------------------------------LRESRKH YIL042C_Scer_PDHK -----------------------------------------------------LQEIQSC BCKDK_Spur_BCKDK -----------------------------------------------------FRECRKH PDHK_Spur_PDHK -----------------------------------------------------ILEMRES aSWK467_Cele_PDHK -----------------------------------------------------LIELRES pdhk-2_Cele_PDHK -----------------------------------------------------LIELRES CC1G_13956_Ccin_BCKDK ----------------------------------------------------------E- CC1G_00337_Ccin_BCKDK -----------------------------------------------------LSLSS-- CC1G_15212_Ccin_PDHK ALTELSIPFTLPQCLHAPLLGFLSLSLTHALASRLPPTFLVTGPRLPRTDLLCVLEWKRS PDHK4_Hsap_PDHK CT--VDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSD-S---QTGN--PSHIGSIDP PDHK3_Hsap_PDHK FG--FDPFISTNIQYFLDRFYTNRISFRMLINQHTLLFGGDT---NPVH--PKHIGSIDP PDHK2_Hsap_PDHK YG--DDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST---NPAH--PKHIGSIDP PDHK1_Hsap_PDHK FG--VDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKG-KGSPSH--RKHIGSINP PDK_Dmel_PDHK EGGQVDAPTESSIQYFLDRLYMSRISIRMLINQHTLLFGG-N---PHAG--GRHIGCLDP PDHK4_Mmus_PDHK CT--VDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSD-S---KTGN--PSHIGSIDP PDHK3_Mmus_PDHK FG--FDPFISSNIQYFLDRFYTNRISFRMLINQHTLLFGGDT---NPAH--PKHIGSIDP PDHK2_Mmus_PDHK YG--DDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGST---NPAH--PKHIGSIDP PDHK1_Mmus_PDHK FG--VDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKG---SPSH--RKHIGSINP BCKDK_Mmus_BCKDK IQ------DEKLVRYFLDKTLTSRLGIRMLATHHLALHED--------K--PDFVGIICT BCKDK_Hsap_BCKDK IE------DEKLVRYFLDKTLTSRLGIRMLATHHLALHED--------K--PDFVGIICT YIL042C_Scer_PDHK -------YPKFQISQFLNFHLKERITMKLLVTHYLSLMAQNK---GDTN--KRMIGILHR BCKDK_Spur_BCKDK IT------DESLIHNFLDRILTSRLGIRMLAEHHLFLHQD--------K--NDSIGIIAT PDHK_Spur_PDHK YK--VDQHEENNVQYFLDRFYISRISIRMLINQHTLMFGQ-I---PTTH--PLLVGSIDP aSWK467_Cele_PDHK DG--VDIASEKGIQYFLDRFYINRISIRMLQNQHLVVFGN-V---LPES--PRHVGCIDP pdhk-2_Cele_PDHK DG--VDIASEKGIQYFLDRFYINRISIRMLQNQHLVVFGN-V---LPES--PRHVGCIDP CC1G_13956_Ccin_BCKDK -S--AKYMSFEDINAFLDGAIRNRISVRLIAEQHIAVTRALH--DPPQD--GKDVGVIDT CC1G_00337_Ccin_BCKDK -----PFLSPDKLDSFMRRMLVSRISRRVLAEHHIALSKTYLAKDSPAHEAEPRVGIIYT CC1G_15212_Ccin_PDHK QN--ARH-IGLDIQAWLDRFYMSRIGIRFLIGQHVALNTQ------QAH--EDYVGIICT : :: .*: :.: :: : :* : PDHK4_Hsap_PDHK N----------------------------------------------------------- PDHK3_Hsap_PDHK T----------------------------------------------------------- PDHK2_Hsap_PDHK N----------------------------------------------------------- PDHK1_Hsap_PDHK N----------------------------------------------------------- PDK_Dmel_PDHK A----------------------------------------------------------- PDHK4_Mmus_PDHK N----------------------------------------------------------- PDHK3_Mmus_PDHK T----------------------------------------------------------- PDHK2_Mmus_PDHK N----------------------------------------------------------- PDHK1_Mmus_PDHK N----------------------------------------------------------- BCKDK_Mmus_BCKDK R----------------------------------------------------------- BCKDK_Hsap_BCKDK R----------------------------------------------------------- YIL042C_Scer_PDHK D----------------------------------------------------------- BCKDK_Spur_BCKDK K----------------------------------------------------------- PDHK_Spur_PDHK S----------------------------------------------------------- aSWK467_Cele_PDHK A----------------------------------------------------------- pdhk-2_Cele_PDHK A----------------------------------------------------------- CC1G_13956_Ccin_BCKDK R----------------------------------------------------------- CC1G_00337_Ccin_BCKDK A----------------------------------------------------------- CC1G_15212_Ccin_PDHK KAVRVPPSPSPFDTLFHFFGTSSAIEPHTDETAFLFLFRMRLVVVVVDVIVMDTLVVVMR PDHK4_Hsap_PDHK ------------------------------------------CDVVAVVQDAFECSRMLC PDHK3_Hsap_PDHK ------------------------------------------CNVADVVKDAYETAKMLC PDHK2_Hsap_PDHK ------------------------------------------CNVSEVVKDAYDMAKLLC PDHK1_Hsap_PDHK ------------------------------------------CNVLEVIKDGYENARRLC PDK_Dmel_PDHK ------------------------------------------CDLSDVVRDAYENARFLC PDHK4_Mmus_PDHK ------------------------------------------CDVVAVVQDAFECAKMLC PDHK3_Mmus_PDHK ------------------------------------------CNVADVVKDAYETAKMLC PDHK2_Mmus_PDHK ------------------------------------------CSVSDVVKDAYDMAKLLC PDHK1_Mmus_PDHK ------------------------------------------CDVVEVIKDGYENARRLC BCKDK_Mmus_BCKDK ------------------------------------------LSPKKIIEKWVDFARRLC BCKDK_Hsap_BCKDK ------------------------------------------LSPKKIIEKWVDFARRLC YIL042C_Scer_PDHK ------------------------------------------LPIAQLIKHVSDYVNDIC BCKDK_Spur_BCKDK ------------------------------------------MSLKKVIEKWVSFAREQC PDHK_Spur_PDHK ------------------------------------------CDIVAVIRDAYDSAKYLC aSWK467_Cele_PDHK ------------------------------------------CDVESVVYDAFENARFLC pdhk-2_Cele_PDHK ------------------------------------------CDVESVVYDAFENARFLC CC1G_13956_Ccin_BCKDK ------------------------------------------CSPKEMVDVCGSFVGDLC CC1G_00337_Ccin_BCKDK ------------------------------------------LDVKRCIDRCSTILRDRP CC1G_15212_Ccin_PDHK SRYLDSTRLGRCDVFGIWFCLDLGGYGAISRTFYTCAVISGLWNVHDIVQEAIENARFVC : PDHK4_Hsap_PDHK -------DQYYLS--SPELKLTQVNGKFP-DQPIHIVYVPSHLHHMLFELFKNAMRATVE PDHK3_Hsap_PDHK -------EQYYLV--APELEVEEFNAKAP-DKPIQVVYVPSHLFHMLFELFKNSMRATVE PDHK2_Hsap_PDHK -------DKYYMA--SPDLEIQEINAANS-KQPIHMVYVPSHLYHMLFELFKNAMRATVE PDHK1_Hsap_PDHK -------DLYYIN--SPELELEELNAKSP-GQPIQVVYVPSHLYHMVFELFKNAMRATME PDK_Dmel_PDHK -------DQYYLT--SPALEIQQHSSEPGDNLPIRTVYVPSHLYYMLFELFKNSMRAVVE PDHK4_Mmus_PDHK -------DQYYLT--SPELNLTQVNGKFP-GQPIHIVYVPSHLHHMLFELFKNAMRATVE PDHK3_Mmus_PDHK -------EQYYLV--APELEVEEFNAKAP-NKPIQVVYVPSHLFHMLFELFKNSMRATVE PDHK2_Mmus_PDHK -------DKYYMA--SPDLEIQEVNATNA-NQPIHMVYVPSHLYHMLFELFKNAMRATVE PDHK1_Mmus_PDHK -------DLYYVN--SPELELEELNAKSP-GQTIQVVYVPSHLYHMVFELFKNAMRATME BCKDK_Mmus_BCKDK -------EHKYGN--APRVRINGHV-------AARFPFIPMPLDYILPELLKNAMRATME BCKDK_Hsap_BCKDK -------EHKYGN--APRVRINGHV-------AARFPFIPMPLDYILPELLKNAMRATME YIL042C_Scer_PDHK -------FVKFNTQRTPVLIHPP-------SQDITFTCIPPILEYIMTEVFKNAFEAQIA BCKDK_Spur_BCKDK -------ELRFGY--APSVKINGHT-------GATFPYIIQPLDYMLPELLKNAMRATIE PDHK_Spur_PDHK -------DQYYLA--SPDIDVRWIDARDG-SDSIRMVYVPSHLYHIMFELLKNAMRAVME aSWK467_Cele_PDHK -------DRYYLT--SPSMKLEMHNAVEK-GKPISIVAVPSHLYHMMFELFKNAMRATVE pdhk-2_Cele_PDHK -------DRYYLT--SPSMKLEMHNAVEK-GKPISIVAVPSHLYHMMFELFKNAMRATVE CC1G_13956_Ccin_BCKDK -------RATLGS--APEIVVDG-------YPEATFAYIPVHLEYVLTELLKNSFRATVE CC1G_00337_Ccin_BCKDK LWVHGNEDVRIDA--WPEVEVEG-------HLDTKFAYIRDHLEYIVFELLKNAMSATVL CC1G_15212_Ccin_PDHK -------EEHYAMFKGPPVQLIC-------PPSLTFAYVPGHLSHICFELLKNSLRAVVE * : : * :: *::**:: * : PDHK4_Hsap_PDHK HQE-NQ--PSLTPIEVIVVLGKED-----------------LTIKISDRGGGVPLR---- PDHK3_Hsap_PDHK LYE-DR-KEGYPAVKTLVTLGKED-----------------LSIKISDLGGGVPLR---- PDHK2_Hsap_PDHK SHE-SS--LILPPIKVMVALGEED-----------------LSIKMSDRGGGVPLR---- PDHK1_Hsap_PDHK HHA-NR--GVYPPIQVHVTLGNED-----------------LTVKMSDRGGGVPLR---- PDK_Dmel_PDHK HHGHDN-NDTLPPLKVAICKGKED-----------------ICVKISDQGGGIPRS---- PDHK4_Mmus_PDHK HQE-NR--PSLTPVEATVVLGKED-----------------LTIKISDRGGGVPLR---- PDHK3_Mmus_PDHK LHE-DK-KEGYPAVKTLVTLGKED-----------------LSIKISDLGGGVPLR---- PDHK2_Mmus_PDHK SHE-SS--LTLPPIKIMVALGEED-----------------LSIKMSDRGGGVPLR---- PDHK1_Mmus_PDHK HHA-DK--GVYPPIQVHVTLGEED-----------------LTVKMSDRGGGVPLR---- BCKDK_Mmus_BCKDK SHL-DT-PYNVPDVVITIANNDID-----------------LIIRISDRGGGIAHK---- BCKDK_Hsap_BCKDK SHL-DT-PYNVPDVVITIANNDVD-----------------LIIRISDRGGGIAHK---- YIL042C_Scer_PDHK LG---KE--H-MPIEINLLKP----------------DDDELYLRIRDHGGGITPE---- BCKDK_Spur_BCKDK SHL-DT-PMNLPDVVITIASNEVDFIISFGWQNQLIEYDNDVLNRISDRGGGIPHS---- PDHK_Spur_PDHK HKG-PS-ASEFPPIGILVTKGKED-----------------VTIKVSDEGGGIPKS---- aSWK467_Cele_PDHK YHG-VD--DDLPDIKVYVVKGQED-----------------LSIKICDRGGGVSRT---- pdhk-2_Cele_PDHK YHG-VD--DDLPDIKVYVVKGQED-----------------LSIKICDRGGGVSRT---- CC1G_13956_Ccin_BCKDK HHARSKERGSLPPIQITLSPPPASSH--SG---HNVDRPNFFSIRIRDQGGGVSRQ---- CC1G_00337_Ccin_BCKDK KHHDS--GSSLPPIRVTIVAG-----------------EDDISLRISDQGGGLTSVNAPT CC1G_15212_Ccin_PDHK RYGVDA-EDHFPPIKVIVVEG-----------------KEDITIKISDEGGGIARS---- : : . :: * ***:. PDHK4_Hsap_PDHK -IIDRLFSYTYSTAPTPVMDNS-------------------------------------- PDHK3_Hsap_PDHK -KIDRLFNYMYSTAPRPSLEPT-------------------------------------- PDHK2_Hsap_PDHK -KIERLFSYMYSTAPTPQP-GT-------------------------------------- PDHK1_Hsap_PDHK -KIDRLFNYMYSTAPRPRVETS-------------------------------------- PDK_Dmel_PDHK -QTDQLFKYMYSTAPQPSKSDL-------------------------------------- PDHK4_Mmus_PDHK -ITDRLFSYTYSTAPTPVMDNS-------------------------------------- PDHK3_Mmus_PDHK -KIDRLFNYMYSTAPRPSLEPT-------------------------------------- PDHK2_Mmus_PDHK -KIERLFSYMYSTAPTPQP-GT-------------------------------------- PDHK1_Mmus_PDHK -KIDRLFNYMYSTAPRPRVETS-------------------------------------- BCKDK_Mmus_BCKDK -DLDRVMDYHFTTAEASTQDPR----------------INPLFGHL-------------- BCKDK_Hsap_BCKDK -DLDRVMDYHFTTAEASTQDPR----------------ISPLFGHL-------------- YIL042C_Scer_PDHK -VEALMFNYSYSTHTQQSADSES---------------T--------------------- BCKDK_Spur_BCKDK -LLKKVFQYHFTTANDDESVSDNGGALGTMIEAVNQPTAGPLCGISDRGGGIP---HSLL PDHK_Spur_PDHK -EIDLLFNYMYSTAPAPPKPGV-------------------------------------- aSWK467_Cele_PDHK -ILERLYNYMYSTAPPPPRDG--------------------------------------- pdhk-2_Cele_PDHK -ILERLYNYMYSTAPPPPRDG--------------------------------------- CC1G_13956_Ccin_BCKDK -HLERIFSYAFTTVKTGDDEGPD---------------W--------------------- CC1G_00337_Ccin_BCKDK NDPMDLFSFSHIRNAS-RLEDSR---------------LG--ALRTASEEGLRATVDEQL CC1G_15212_Ccin_PDHK -AIPLIWTYMYTTMEHQTSLDED------------------------------------- : : . PDHK4_Hsap_PDHK -------------------------------------RNAPLAGFGYGLPISRLYAKYFQ PDHK3_Hsap_PDHK -------------------------------------RAAPLAGFGYGLPISRLYARYFQ PDHK2_Hsap_PDHK -------------------------------------GGTPLAGFGYGLPISRLYAKYFQ PDHK1_Hsap_PDHK -------------------------------------RAVPLAGFGYGLPISRLYAQYFQ PDK_Dmel_PDHK -------------------------------------HTVPLAGYGYGLPISRLYARYFH PDHK4_Mmus_PDHK -------------------------------------RNAPLAGFGYGLPISRLYAKYFQ PDHK3_Mmus_PDHK -------------------------------------RAAPLAGFGYGLPISRLYARYFQ PDHK2_Mmus_PDHK -------------------------------------GGTPLAGFGYGLPISRLYAKYFQ PDHK1_Mmus_PDHK -------------------------------------RAVPLAGFGYGLPISRLYAQYFQ BCKDK_Mmus_BCKDK --------------D-----------------MHSGGQSGPMHGFGFGLPTSRAYAEYLG BCKDK_Hsap_BCKDK --------------D-----------------MHSGAQSGPMHGFGFGLPTSRAYAEYLG YIL042C_Scer_PDHK --------------------------------DLPGEQINNVSGMGFGLPMCKTYLELFG BCKDK_Spur_BCKDK KKVFQYHFTTA-NDDESVSDNGGA--LGTMIEAVNQPTAGPLCGFGFGLPVSKAYAEYLG PDHK_Spur_PDHK ------------------------------------SIIPPLAGYGYGLPISRLYAKYFH aSWK467_Cele_PDHK ------------------------------------T-QAPLAGYGYGLPLSRLYARYFL pdhk-2_Cele_PDHK ------------------------------------T-QAPLAGYGYGLPLSRLYARYFL CC1G_13956_Ccin_BCKDK --------------DT-SDSREDEPFLGVMTQRTLQTGLGTIAGLGYGLPMSKLYTKYFG CC1G_00337_Ccin_BCKDK SRWQKHSYYQPKNRDK-LEEHGTA--------PSQEIMNIVRSRIGIGLPMSNIYATYFG CC1G_15212_Ccin_PDHK --------------------------------FQASDFKAPMAGFGYGLPLSRLYARYFG * *** .. * : PDHK4_Hsap_PDHK GDLNLYSLSGYGTDAIIYLKALSSESIEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNL PDHK3_Hsap_PDHK GDLKLYSMEGVGTDAVIYLKALSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDA PDHK2_Hsap_PDHK GDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNT PDHK1_Hsap_PDHK GDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDM PDK_Dmel_PDHK GDIVLLSCEGFGTDAIIYLKALSDEANELLPIFNKTSSKFYRATVPTGDWSNQVKYAKKK PDHK4_Mmus_PDHK GDLNLYSMSGYGTDAIIYLKALSSESVEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNL PDHK3_Mmus_PDHK GDLKLYSMEGVGTDAVIYLKALSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDA PDHK2_Mmus_PDHK GDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNT PDHK1_Mmus_PDHK GDLKLYSLEGYGTDAVIYIKALSTESVERLPVYNKAAWKHYKANHEADDWCVPSREPKDM BCKDK_Mmus_BCKDK GSLQLQSLQGIGTDVYLRLRHIDGRE---------------------------------- BCKDK_Hsap_BCKDK GSLQLQSLQGIGTDVYLRLRHIDGRE---------------------------------- YIL042C_Scer_PDHK GKIDVQSLLGWGTDVYIKLKGPSKTA-L-------------------------------- BCKDK_Spur_BCKDK GSISLETMQGIGTDVYLRLRHIDGKQ---------------------------------- PDHK_Spur_PDHK GDLTLSSMDGYGTDAVVYLKVLSSEASELLPIYNSAVSRYYKTPTPASDWSTPGYFIRNY aSWK467_Cele_PDHK GDLFLVSMEGHGTDACIYLKAVPVEASEVLPIYSTSSRRNLTMGPQVADWSHH--VPGQG pdhk-2_Cele_PDHK GDLFLVSMEGHGTDACIYLKAVPVEASEVLPIYSTSSRRNLTMGPQVADWSHH--VPGQG CC1G_13956_Ccin_BCKDK GSLDLISLEGWGSDVYIKLRCLDEAG-D-------------------------------- CC1G_00337_Ccin_BCKDK GSLELVSLDGWGTDVFLRLPKLGTNL-E-------------------------------- CC1G_15212_Ccin_PDHK GDLRLIAMDGFGTDVYIHLNRLSSSR-E-------------------------------- *.: : : * *:*. : : PDHK4_Hsap_PDHK AK----------EVAM PDHK3_Hsap_PDHK SKYKAKQDKIKTNRTF PDHK2_Hsap_PDHK ST----------YRVS PDHK1_Hsap_PDHK TT----------FRSA PDK_Dmel_PDHK KTS---------AVSQ PDHK4_Mmus_PDHK AKE---------KLAV PDHK3_Mmus_PDHK SKYKAKQDKIKSNRTF PDHK2_Mmus_PDHK ST----------YRVS PDHK1_Mmus_PDHK TT----------FRSS BCKDK_Mmus_BCKDK -E----------SFRI BCKDK_Hsap_BCKDK -E----------SFRI YIL042C_Scer_PDHK ------------LSKK BCKDK_Spur_BCKDK -E----------SFRI PDHK_Spur_PDHK TTK---------RYGK aSWK467_Cele_PDHK NR----------PAQS pdhk-2_Cele_PDHK NR----------PAQS CC1G_13956_Ccin_BCKDK -------------SNI CC1G_00337_Ccin_BCKDK ------------GIEV CC1G_15212_Ccin_PDHK -------------PLP