CLUSTAL W (1.83) multiple sequence alignment TRRAP_Hsap_TRRAP MAFVATQGA-TV-VDQ-T-TL-M---KK-------------------------------- SMG1_Hsap_SMG1 MSRRAPGSR-LSSG--GG-GG-G---TK-----------YP-RSWNDWQPR-TDSASADP FRAP_Hsap_FRAP MLGTGPAAA-TTAA--TT--------SS-------------------------------- mei-41_Dmel_ATR MYAKSLL---EV-LQH-A------------------------------------------ CG2905_Dmel_TRRAP MSVIENVPV-N----------------T-------------------------------- CG6535_Dmel_ATM MSALLNEIQ-RI------------------------------------------------ CG4549_Dmel_SMG1 MKNAIHPEN-CNG---AG-TE-----EE-----------AS----SAFH--------AEI FRAP_Mmus_FRAP MLGTGPAVA-TASA--AT--------SS-------------------------------- DNAPK_Mmus_DNAPK MAEEGTGVR-CW-LLQ-LQEF-L---SAADRCS-AAGAS--------------------- ATR_Mmus_ATR MGDHGLELA-SM-IPA-L------------------------------------------ ATM_Mmus_ATM MSLALNDLL-IC------------------------------------------------ C47D12.1_Cele_TRRAP MDPAMASPG-YRSVQSDR--------SN-------------------------------- B0261.2_Cele_FRAP MLQQHGISF-QMNA--D-RQN-KAA--T-------------------------------- atm-1_Cele_ATM MKHYKKIIH--------------------------------------------------- atl-1_Cele_ATR MNIDKDVSA-LL-CTA-K-KY-V---TQ-------------------------------- TEL1_Scer_ATM MEDHGIV---ET-LN--------------------------------------------- MEC1_Scer_ATR MESHVKYLD-EL------------------------------------------------ ATM_Hsap_ATM MSLVLNDLL-IC------------------------------------------------ ATR_Hsap_ATR MGEHGLELA-SM-IPA-L------------------------------------------ DNAPK_Hsap_DNAPK MAGSGAGVR-CS-LLR-LQET-L---SAADRCG-AALAG--------------------- TOR_Dmel_FRAP MSTTSVV----------------------------------------------------- SMG1_Mmus_SMG1 MSRRAPGSR-LSSG--GG----G---TK-----------YP-RSWNDWQPR-TDSASADP TRRAP_Mmus_TRRAP MAFVATQGA-TV-VDQ-T-TL-M---KK-------------------------------- smg-1_Cele_SMG1 MITSRNNDI-G------------------------------------------------- TOR1_Scer_FRAP MEPHEEQIW-KS-KLLKAANN-DMDMDR-------------------------------- TOR2_Scer_FRAP MNKYINKYT-TPPNLLSLRQR-AEGKHR-------------------------------- TRA1_Scer_TRRAP MSLTEQIE---------------------------------------------------- ATR_Ddis_ATR MPSEQFQ---EQ-QRQQQ------------------------------------------ DNAPK_Ddis_DNAPK MDNIYQRIE-NY-LIK-LFQT-I---SETNNNNNNNNTNN-------------------- SMG1_Ddis_SMG1 MNDSNSSND-SCNT--EN-NT-L---TA-----------TK-NSINNTTTT-TTTPNNNV Tor_Ddis_FRAP MSQHEQPSI--------------------------------------------------- TRRAP_Ddis_TRRAP MSTNPPQPP-PSST--IAS--------N-----------P-------PQPIATPMSTTNP ATMa_Spur_ATM KQIDIVKKE-L------------------------------------------------- ATR_Spur_ATR SSYQMRQR---------------------------------------------------- DNAPK_Spur_DNAPK MIVCALLEYRSD-DVW-LEDDVV---NREIRKR--------------------------- FRAP_Spur_FRAP MSQMNS------------------------------------------------------ SMG1_Spur_SMG1 LT---------------------------------------------------------- TRRAP_Spur_TRRAP DETRLK------------------------------------------------------ CC1G_00839_Ccin_ATM MASTLKSIL--DALKDG------------------------------------------- CC1G_08126_Ccin_ATR MSTNASKAT-TE-LDG-AANA-N----------SSNFKN--------------------- CC1G_00894_Ccin_FRAP MASADQAPV-GDQ----------------------------------------------- CC1G_06302_Ccin_PI3K MDKDNRDDF-TFAR--L------------------------------------------- CC1G_04234_Ccin_PI4K MQAALNDLS-V------------------------------------------------- CC1G_13883_Ccin_PI4K MDCLEFNI---------------------------------------------------- CC1G_00331_Ccin_TRRAP MSQVQRAMV-SPSIQG-TI----------------------------------------- AqueK043_Aque_ATM MAPYVLLNL-Y------------------------------------------------- AqueK044_Aque_ATR MLMVGKL------LE--------------------------------------------- AqueK045_Aque_DNAPK MSSSGYKFG-HN-NSE-GKE---------------------------------------- AqueK046_Aque_FRAP TN---------------------------------------------------------- AqueK047_Aque_SMG1 MLYTTIMPV-FFTR--V------------------------------------DMIENSP AqueK048_Aque_TRRAP MNFMEA------------------------------------------------------ ATM_Smoe_ATM MYMVFQIEE-AK------------------------------------------------ ATR_Smoe_ATR MIFCRGM---DE-DN--------------------------------------------- DNAPK_Smoe_DNAPK MLVESDTSA-QL-GRT-KLDL-L---I--------------------------------- FRAP_Smoe_FRAP MAGAQGVAP-RPP---D------------------------------------------- SMG1_Smoe_SMG1 MAEMLLQTL-ASQV--RAAHT-F---DD-----------HGGGGGAAVTAA----ALPPP GK008_Glam_FRAP MSTDAITSS-R------------------------------------------------- GK009_Glam_PIKK-Unclassified MLASSLRSL-MANY--HATGGVV---QD-------------------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 DNLKYS--SSRDRGGSSSY----------------------------------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ---------------------------YQ------------------------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP -----------------TSN--------RIVS---APATNE-FD---------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ---------------------------HQ------------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 DTLKYS--SSRDRGVSSSY----------------------------------------- TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -------------------N--------VP----LAPNLNVNMNMKMNASRNGDEF--GL TOR2_Scer_FRAP -----------------TRK--------KLTHKSH------SHDDEMSTTSNTDSNHNGP TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -------------------NVGIKFENDLL------------------------------ SMG1_Ddis_SMG1 NCLKTS--GSIK------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP SQPTITSSSAASSSSSSSSG---------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ---------------------------SG------------------------------- CC1G_00894_Ccin_FRAP ----------------------------Q------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 SELS-------------------------------------------------------- AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------------------------A------------------------------- SMG1_Smoe_SMG1 PLLP------------S------------------------------------------- GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP --------------------------------YL-----------------QFV------ SMG1_Hsap_SMG1 -------------------------------GLQ-----------------PSN------ FRAP_Hsap_FRAP ----------------------------NVSVLQ-----------------QFA------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP --------------------------------FR-----------------NYL------ CG6535_Dmel_ATM -----------------------------------------------------L------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------------------------NVSVLQ-----------------QFA------ DNAPK_Mmus_DNAPK ----------------------------LIR------------SL--------G----QE ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM -----------------------------------------------------C------ C47D12.1_Cele_TRRAP ----------------------------HLTELE-----------------TRI------ B0261.2_Cele_FRAP ----------------------ERHRKQGIDAAR-----------------ALA------ atm-1_Cele_ATM ---------------------------------------------------QVL------ atl-1_Cele_ATR ------------------------------KEFNRQKMKFLLDDITKLLSKSFV------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR -----------------------------------------------------I------ ATM_Hsap_ATM -----------------------------------------------------C------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ----------------------------LIR------------GL--------G----QE TOR_Dmel_FRAP ---------------------------------Q-----------------QFV------ SMG1_Mmus_SMG1 -------------------------------GLQ-----------------PSN------ TRRAP_Mmus_TRRAP --------------------------------YL-----------------QFV------ smg-1_Cele_SMG1 ---------------------------------------------------NLI------ TOR1_Scer_FRAP TSSRFDGVVIGS---NGDVN--------FKPILE-----------------KIF------ TOR2_Scer_FRAP --NDSGRVITGSAGHIGKISFVDSELDTTFSTLN-----------------LIF------ TRA1_Scer_TRRAP ---------------------------------------------------QFA------ ATR_Ddis_ATR ------------------------------Q------------QY--------Q------ DNAPK_Ddis_DNAPK ----------------------------LVN------------EL--------GSIILKE SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------------------------WADALT-----------------KLL------ TRRAP_Ddis_TRRAP ----------------------------NPVNFE-----------------SYA------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ----------------------------------------------------LV------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ----------------------------LFK------------SL--------N------ CC1G_00894_Ccin_FRAP --------------------------------LN-----------------AIF------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K --------------------------------HQ-----------------RIL------ CC1G_00331_Ccin_TRRAP -----------------------------------------------------A------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM -----------------------------------------------------V------ ATR_Smoe_ATR ------------------------------E------------QV--------Q------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------------------------------LQ-----------------RLL------ SMG1_Smoe_SMG1 ---------------------------------V-----------------QVC------ GK008_Glam_FRAP --------------------------------FY-----------------PYL------ GK009_Glam_PIKK-Unclassified ------------------------------AELL-----------------ALS------ TRRAP_Hsap_TRRAP --------------AA---LTD--------V--N------TP-D-E------------TK SMG1_Hsap_SMG1 --------------SAV-VSRQ--------R--H------D----D------------TR FRAP_Hsap_FRAP --------------SG---LKS--------R--N------E----E------------TR mei-41_Dmel_ATR --------------------HH--------I--G------YA-THG------------D- CG2905_Dmel_TRRAP --------------NI---LND--------S--S------SK-D-E------------LK CG6535_Dmel_ATM --------------GD---LQS--------G--K------A----A------------SR CG4549_Dmel_SMG1 -------------------DRV--------L--L------N----N------------NG FRAP_Mmus_FRAP --------------SG---LKS--------R--N------E----E------------TR DNAPK_Mmus_DNAPK CVLSTSSAVQALQISL---VFSRDFGLLVFI--RK--SLSI------------------- ATR_Mmus_ATR --------------------RE--------L--A------SA-T-P------------E- ATM_Mmus_ATM --------------RQ---LEH--------D--R------A----T------------ER C47D12.1_Cele_TRRAP --------------QN---LAD--------NSQR------D----D------------VK B0261.2_Cele_FRAP --------------SQ---YRS--------R--I------TENRDA------------NQ atm-1_Cele_ATM --------------LK---LHS--------VCI--------------------------- atl-1_Cele_ATR --------------SR---IEQ--------L--D------ENEF-M------------EK TEL1_Scer_ATM ---------------------F--------L--S------ST-K-I------------K- MEC1_Scer_ATR --------------LA---IKD--------L--N------SG-V-D------------SK ATM_Hsap_ATM --------------RQ---LEH--------D--R------A----T------------ER ATR_Hsap_ATR --------------------RE--------L--G------SA-T-P------------E- DNAPK_Hsap_DNAPK CVLSSSPAVLALQTSL---VFSRDFGLLVFV--RK--SLNS------------------- TOR_Dmel_FRAP --------------NG---LKS--------R--N------R----N------------VQ SMG1_Mmus_SMG1 --------------SAV-VSRQ--------R--H------D----D------------TR TRRAP_Mmus_TRRAP --------------AA---LTD--------V--N------TP-D-E------------TK smg-1_Cele_SMG1 --------------EQ---FRQ--------R----------------------------- TOR1_Scer_FRAP --------------RE---LTS--------D--Y------K----E------------ER TOR2_Scer_FRAP --------------DK---LKS--------D--V------P----Q------------ER TRA1_Scer_TRRAP --------------SR---FRD--------D--D------AT-L-Q------------SR ATR_Ddis_ATR --------------------QQ--------L--E------RE-R-Q------------E- DNAPK_Ddis_DNAPK LVLE---EEIGLVASL---LFTGDHSLLKYL--EKSSTISN------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP --------------ND---LKS--------K--K------E----E------------DR TRRAP_Ddis_TRRAP --------------RRCFELNN--------N--N------E----Q------------TQ ATMa_Spur_ATM --------------NK--------------K--T------V------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -------YGMAIYSAV---LTQWE-------------TL--------------------- FRAP_Spur_FRAP --------------GG---LKS--------R--H------D----D------------VR SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ---------------------------------T------A----T------------AR CC1G_08126_Ccin_ATR --------------QV---LED--------L--K---RRPEG-F-D------------PA CC1G_00894_Ccin_FRAP --------------SG---LKS--------R--S------A----D------------TR CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K --------------SE---LAS--------K--Q------D----D------------TP CC1G_00331_Ccin_TRRAP --------------PA---FEM--------L--A---QESSAQH-K------------AR AqueK043_Aque_ATM --------------SE----GS--------L--C------P----D------------I- AqueK044_Aque_ATR ---------------------E--------T--D------HD-S---------------- AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM --------------L--------------------------------------------- ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------------SE---LRF--------K--T------A----S------------IK SMG1_Smoe_SMG1 --------------TLL-K---------------------M----N------------LQ GK008_Glam_FRAP --------------AD---LKS--------I--D------P----N------------IY GK009_Glam_PIKK-Unclassified --------------DG---LLE--------D--A------RR-S-PVSCAFAASLAIRTA TRRAP_Hsap_TRRAP LK-MM--Q---------------------------------------EVSENF----ENV SMG1_Hsap_SMG1 V-HAD--IQNDEKGGYSVNGGSGE-------------------------------N---- FRAP_Hsap_FRAP AK-AA--K---------------------------------------ELQ-----HYV-- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP LK-AT--Q---------------------------------------ELSEHF----EMI CG6535_Dmel_ATM NK-GI--Q---------------------------------------QLD-----EKL-- CG4549_Dmel_SMG1 N-HGD--SSNEGGGGNGSGRGGATGSGNIAGLGGSESMWSPGGGKSHDVA-----Q---- FRAP_Mmus_FRAP AK-AA--K---------------------------------------ELQ-----HYV-- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM RK-EV--D---------------------------------------KFK-----RLI-- C47D12.1_Cele_TRRAP LK-ML--Q---------------------------------------EIWSTI----ENH B0261.2_Cele_FRAP RQ-AA--R---------------------------------------ELS-----RYV-- atm-1_Cele_ATM -G-QL--S---------------------------------------KLEEYR----ETR atl-1_Cele_ATR IM-ILQSI---------------------------------------TFTLHLITEKQEL TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR VQ---------------------------------------------------------- ATM_Hsap_ATM KK-EV--E---------------------------------------KFK-----RLI-- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP NK-AT--Q---------------------------------------DLL-----FYV-- SMG1_Mmus_SMG1 G-HAD--IQNDEKGGYSVNGGSGE-------------------------------N---- TRRAP_Mmus_TRRAP LK-MM--Q---------------------------------------EVSENF----ENV smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP KL-AS--I---------------------------------------SLF-----DLL-- TOR2_Scer_FRAP AS-GA--N---------------------------------------ELS-----TTL-- TRA1_Scer_TRRAP YS-TL--S---------------------------------------ELYDIM----ELL ATR_Ddis_ATR KE-QN------------------------------------------------------- DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 L-SAS--SVPFI---------PGS-------------------------------S---- Tor_Ddis_FRAP VK-AS--K---------------------------------------NLK-----SYV-- TRRAP_Ddis_TRRAP LLALV--T---------------------------------------EIR-----DNIEL ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP TR-AA--K---------------------------------------NLQ-----HYV-- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ---AA--Q---------------------------------------EISENF----EVI CC1G_00839_Ccin_ATM KE-AL--Q---------------------------------------EFRTAV----FAD CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP MQ-AA--E---------------------------------------DLK-----RFV-- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K GQDSS--K---------------------------------------DLI----ISKV-- CC1G_00331_Ccin_TRRAP TD-FEAMG---------------------------------------GIWAGMAPTIKNP AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 --SL-------------------------------------------------------- AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP DGAAA--A---------------------------------------ALR-----KHV-- SMG1_Smoe_SMG1 M-LA-------------------------------------------------------- GK008_Glam_FRAP TRAA---M---------------------------------------AIR-----MQV-- GK009_Glam_PIKK-Unclassified GE-GP--E---------------------------------------RLE-----RIV-- TRRAP_Hsap_TRRAP T-------SSP-----QYSTFLEHIIPRFLT------------------FLQDGEVQFLQ SMG1_Hsap_SMG1 -------------------TYGRKSLGQELR------------------VNNVTSPEFT- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ----------------IF------------------------------------------ CG2905_Dmel_TRRAP M-------QSP-----AYPSFLDNSLKIFMR------------------ILQDGEPQFIQ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 -------------------AFANALL---LRN-----------------MNHVVGKGQP- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ----------E-----DF------------------------------------------ ATR_Mmus_ATR ----------------EY------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP F-------TLSSH-----EKVVERLILSFLQ------------------VFCNTSPQFIA B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM T-------YRMKQ----------------------------------------------- atl-1_Cele_ATR --------SSE-----EKIRLFQ------------------------------------- TEL1_Scer_ATM ----------------ER------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ----------------EY------------------------------------------ DNAPK_Hsap_DNAPK ----------I-----EF------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 -------------------TYGRKSLGQELR------------------INNVTSPEFT- TRRAP_Mmus_TRRAP T-------SSP-----QYSTFLEHIIPRFLT------------------FLQDGEVQFLQ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP N-------SPE-----DYHFFLQAVIPLLLN------------------QLKEVPISYDA ATR_Ddis_ATR ----------------EK------------------------------------------ DNAPK_Ddis_DNAPK ----------K-----EN------------------------------------------ SMG1_Ddis_SMG1 -------------------AS--------------------------------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP V-------HTV-----EYPTFLNFLFPVFYN------------------ILRQGAVQFN- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP I-------SSS-----QYHSFLETAIPHFLK------------------VLKDEKPQFIA CC1G_00839_Ccin_ATM RDLLPYLTRQKSNDKHAYKDWLSI-VQALLASVQADKPLLRQKIAQGRTVPATVTSRF-- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP T-------IYN-----DL------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -------------------------HSS-LL------------------LLKE------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP EKPAQQLR-----------------------KLVLEIIHRI------------------- SMG1_Hsap_SMG1 --------------------------------------------------S--VQH---- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR SGSLHQ----------------------------------A------------------- CG2905_Dmel_TRRAP ENTMQHIR-----------------------KLILEMIHRL------------------- CG6535_Dmel_ATM ----SSCR--EDLDKLFLSKTS-DISWTTIFEASKEAL---------------------- CG4549_Dmel_SMG1 --------------------------------------------------V--VQN---- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK RDCREEAL-----------------------KFLCVFLEKI------------------- ATR_Mmus_ATR NTVVQKPR-----------------------QILCQFIDRI------------------- ATM_Mmus_ATM ----QDPETVQHLDRHSDSKQGKYLNWDAVFRFLQKYI---------------------- C47D12.1_Cele_TRRAP ENNTQQLR-----------------------KLMLEIILRL------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM QAVTAFEQ-----------------------QIQN------------------------- atl-1_Cele_ATR --------------------------------SVIASM--C------------------- TEL1_Scer_ATM NNALDELT-----------------------TILKEDPERI------------------- MEC1_Scer_ATR -------------------------------------IKKV------------------- ATM_Hsap_ATM ----RDPETIKHLDRHSDSKQGKYLNWDAVFRFLQKYI---------------------- ATR_Hsap_ATR NTVVQKPR-----------------------QILCQFIDRI------------------- DNAPK_Hsap_DNAPK RECREEIL-----------------------KFLCIFLEKM------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 --------------------------------------------------S--VQH---- TRRAP_Mmus_TRRAP EKPAQQLR-----------------------KLVLEILHRI------------------- smg-1_Cele_SMG1 ---------------------------------------------------DTPQK---- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP HSPEQKLR-----------------------NSMLDIFNRC------------------- ATR_Ddis_ATR ESLISNLV-----------------------SLIIE----IQQLGGNEYNS--QNHPINL DNAPK_Ddis_DNAPK VKIKVSIL-----------------------NLIAEFIEIL------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP --------------------------------------------------DGPEQK---- ATMa_Spur_ATM ---------QLQLDKHTLEGKSN-FTWQEVFKCVWAYI---------------------- ATR_Spur_ATR --------------------------------RCAEIFSR-------------------- DNAPK_Spur_DNAPK --------------------------------------SNL------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ESPLQHLR-----------------------KLLLELLHRM------------------- CC1G_00839_Ccin_ATM ------TT-----------------------A---VGTVRW------------------- CC1G_08126_Ccin_ATR -DASHRVL-----------------------EVAQSFLCGY------------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP IQAQIKML-----------------------SYLAFVMRYL------------------- AqueK043_Aque_ATM ---------RCSLA-----------------DALVAAV---------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR EALCSTIG-----------------------KLFCV------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -----P-TNE-------------------------------------------------- SMG1_Hsap_SMG1 -----------------------GSRALA--T-KDMRKSQERSM---------------- FRAP_Hsap_FRAP -------------------------------T-MEL-----REM---------------- mei-41_Dmel_ATR --------------------LLI------------------LKE---------------- CG2905_Dmel_TRRAP -----P-ITE-------------------------------------------------- CG6535_Dmel_ATM -------------------------------F-KQA-----GNLEDVNEKVFKTLAGKNY CG4549_Dmel_SMG1 -----------------------HRKAYQCKG-DT-----INPM---------------- FRAP_Mmus_FRAP -------------------------------T-MEL-----REM---------------- DNAPK_Mmus_DNAPK -----D-QKVM------HYSLDI------------------KN----------------- ATR_Mmus_ATR -----L-TDVN------VVALEL------------------VKK---------------- ATM_Mmus_ATM -------------------------------Q-KEM-----ESLRTAKSNVSATTQ---S C47D12.1_Cele_TRRAP -----S-NVE-------------------------------------------------- B0261.2_Cele_FRAP -------------------------------R-SEL-----KDE---------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -----AFEDE-------------------------------------------------- TEL1_Scer_ATM -----P-TKAL-----STTAEAL------------------VEL---------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -------------------------------Q-KET-----ECLRIAKPNVSASTQ---A ATR_Hsap_ATR -----L-TDVN------VVAVEL------------------VKK---------------- DNAPK_Hsap_DNAPK -----G-QKIA------PYSVEI------------------KN----------------- TOR_Dmel_FRAP -------------------------------K-TEL-----REM---------------- SMG1_Mmus_SMG1 -----------------------GSRALA--T-KDMRKSQERSM---------------- TRRAP_Mmus_TRRAP -----P-TNE-------------------------------------------------- smg-1_Cele_SMG1 -----------------------ERKAI---L-AR-----IEEI---------------- TOR1_Scer_FRAP -------------------------------V-SLE-----HEL---------------- TOR2_Scer_FRAP -------------------------------T-SLA-----REV---------------- TRA1_Scer_TRRAP -----L-MNQ-------------------------------------------------- ATR_Ddis_ATR SKDSIV-DDKNNKKDLDTTSVTNNNKQQQ------------QQN---------------- DNAPK_Ddis_DNAPK -----Q-VRTD------DYAIAI------------------KN----------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -------------------------------I-SQS-----REM---------------- TRRAP_Ddis_TRRAP -----------------------IRNTI---L-DI-----LNKL---------------- ATMa_Spur_ATM -------------------------------V-KEI-----ELLKGKGASSS-RTS---T ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -----G-Q---------------------------------------------------- FRAP_Spur_FRAP -------------------------------S-TEL-----REV---------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----P-TNE-------------------------------------------------- CC1G_00839_Ccin_ATM -----I-VEE-------------------------------------------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP -------------------------------Q-VSY-----AEM---------------- CC1G_06302_Ccin_PI3K ---------------------------------SDLKLPVTFRI---------------- CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -------------------------------QTRDV-----SEV---------------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM -------------------------------S-TD------------------------- AqueK044_Aque_ATR -------QTIL-----KHYK----------------------EV---------------- AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------AAANL------------------VPT---------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------------------------------Q-EEA-----RDL---------------- SMG1_Smoe_SMG1 -------------------------------A-QGLALHPSAAL---------------- GK008_Glam_FRAP -------------------------------E-KDS-----RQM---------------- GK009_Glam_PIKK-Unclassified -------------------------------L-LSD-----LQL---------------- TRRAP_Hsap_TRRAP --------------------------------------------HLRPHTK-NVLS---- SMG1_Hsap_SMG1 -----------------------S-------------YSD----ES-------RLS---- FRAP_Hsap_FRAP -----------------------S-------------QEE----S-TRFYD-QLNH---- mei-41_Dmel_ATR -----------------------CD------------MDT----K--------------- CG2905_Dmel_TRRAP --------------------------------------------SLRQHVK-TIIT---- CG6535_Dmel_ATM LYDNVLEKITQFN---LEAGSQTS--------------GN----GHFLAKT-SIFS---- CG4549_Dmel_SMG1 -----------------------A-------------NGE----DL-------RLS---- FRAP_Mmus_FRAP -----------------------S-------------QEE----S-TRFYD-QLNH---- DNAPK_Mmus_DNAPK -----------------------TCT-----------SVY----T--------------- ATR_Mmus_ATR -----------------------TDA-----------QPT----S--------------- ATM_Mmus_ATM SRQKKMQEISSLVRYFIKCA---N--------------KR----APRLKCQ-DLLN---- C47D12.1_Cele_TRRAP --------------------------------------------AMKHHSK-EIIK---- B0261.2_Cele_FRAP -----------------------P-------------NTF----S-DAFLN-AIDGRTDI atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR --------------------------------------------ELAKCFD-RILS---- TEL1_Scer_ATM -----------------------LAS-----------EHT-------------------- MEC1_Scer_ATR ------------------------PT-----------DPS----S--------------- ATM_Hsap_ATM SRQKKMQEISSLVKYFIKCA---N--------------RR----APRLKCQ-ELLN---- ATR_Hsap_ATR -----------------------TDS-----------QPT----S--------------- DNAPK_Hsap_DNAPK -----------------------TCT-----------SVY----T--------------- TOR_Dmel_FRAP -----------------------S-------------QEE----L-AQFFD-EFDH---- SMG1_Mmus_SMG1 -----------------------S-------------YSD----ES-------RLS---- TRRAP_Mmus_TRRAP --------------------------------------------HLRPHTK-NVLS---- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -----------------------S-------------IEE----F-QAVSN-DINN---- TOR2_Scer_FRAP -----------------------S-------------AEQ----F-QRFSN-SLNN---- TRA1_Scer_TRRAP --------------------------------------------TFQPYAM-EVLE---- ATR_Ddis_ATR -----------------------KTT-----------HKI----Q--------------- DNAPK_Ddis_DNAPK -----------------------TCV-----------LVF----R--------------- SMG1_Ddis_SMG1 ---------------------------------------L----PS-------ILS---- Tor_Ddis_FRAP -----------------------T-------------NEN----F-TKFMN-ELNNN--- TRRAP_Ddis_TRRAP -----------------------P-------------NNE----LLRPHIL-VLLQ---- ATMa_Spur_ATM TNQTRKREVRSTLKWIVGVA---N--------------GR----GPKLSVV-KLVK---- ATR_Spur_ATR -----------------------AKA---------------------------------- DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP -----------------------S-------------ADE----R-TSFMD-ELNH---- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --------------------------------------------QLRTFVR-QILE---- CC1G_00839_Ccin_ATM --------------------------------------------YYEYFSK-SVLD---- CC1G_08126_Ccin_ATR ------------------------A------------SPH----T--------------- CC1G_00894_Ccin_FRAP -----------------------T-------------SDA----A-AKLWDDHINR---- CC1G_06302_Ccin_PI3K -----------------------S-------------QLE----GI-------R------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -----------------------S-------------AEGCPEPT-TRVY---------- CC1G_00331_Ccin_TRRAP -------------------------N-----------ETE----A--------------- AqueK043_Aque_ATM --------LKGNVLFLTRKR---K------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM -WAQGQREL----------------------------------------AV-SLVK---- ATR_Smoe_ATR -----------------------SDM-----------QQL----S--------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -----------------------S-------------AEG----L-TKFLD-ILYD---- SMG1_Smoe_SMG1 -----------------------R-------------LLE-----T-------------- GK008_Glam_FRAP -----------------------L-------------ADP----R-TLFIS-DLMS---- GK009_Glam_PIKK-Unclassified -----------------------GVEQPYVLWILDLQPES----S-ECVLN-WPTTR--- TRRAP_Hsap_TRRAP ----VMFR-FLETENE-----------------------------------ENVLICLRI SMG1_Hsap_SMG1 ----NLLR-RITREDD-------------------------------------RDRRLAT FRAP_Hsap_FRAP ----HIFE-L-------------------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ----MMLK-ILKTDNE-----------------------------------ENVLVCLRI CG6535_Dmel_ATM ----AFED-GIKMR-------------------------------------VV------- CG4549_Dmel_SMG1 ----KIIR-RLINENN-------------------------------------PTVSLEL FRAP_Mmus_FRAP ----HIFE-L-------------------------------------------------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ----YVMD-TVKDS-------------------------------------SN------- C47D12.1_Cele_TRRAP ----QMMR-LITVENE-----------------------------------ENANLAIKI B0261.2_Cele_FRAP ASQSAIYNCM-------------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ----VLMI-SVTKQDP-----------------------------------RETIYFLQG TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ----YIMD-TVKDS-------------------------------------SN------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ----HIFT-M-------------------------------------------------- SMG1_Mmus_SMG1 ----NLLR-RITREDD-------------------------------------RDRRLAT TRRAP_Mmus_TRRAP ----VMFR-FLETENE-----------------------------------ENVLICLRI smg-1_Cele_SMG1 ---------LQTTKNV-----------------------------------ES--LCVKW TOR1_Scer_FRAP ----KILE-L-------------------------------------------------- TOR2_Scer_FRAP ----KIFE-L-------------------------------------------------- TRA1_Scer_TRRAP ----FLLS-VLPKENE-----------------------------------ENGILCMKV ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ----NQYK-LAASNNV-------------------------------------SNNIMMI Tor_Ddis_FRAP ----LIFE-L-------------------------------------------------- TRRAP_Ddis_TRRAP ----LSMY-LLEVDNE-----------------------------------ENALVCLRI ATMa_Spur_ATM ----KMIF-LLKDD-------------------------------------FT------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ----HIFE-L-------------------------------------------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----LMFI-LLEAENE-----------------------------------ENVLVCLKI CC1G_00839_Ccin_ATM ----SLLD-HITSTLLDRRLFDYVSLDYFKTIKSLLLHQPHLDHLDGLRWTNLVEICFNV CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----RLFA-L-------------------------------------------------- CC1G_06302_Ccin_PI3K -----------------------------------------------------------K CC1G_04234_Ccin_PI4K -----------QRRNT-----------------------------------QSFAVCQRV CC1G_13883_Ccin_PI4K -------M-S-------------------------------------------------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ----YLLT-YI------------------------------------------------- ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----RINC-L-------------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----FIRN-L-------------------------------------------------- GK009_Glam_PIKK-Unclassified ----LLLC-L-------------------------------------------------- TRRAP_Hsap_TRRAP II--------ELHKQFRPPITQEIHH--------------------FLDF---------- SMG1_Hsap_SMG1 VK--------QLKEFIQQP----------------------------------------- FRAP_Hsap_FRAP -------------------V---------------------------------------- mei-41_Dmel_ATR -----------------------L-A--------------------SLNY---------- CG2905_Dmel_TRRAP II--------ELHKHFRPSFNSEIQL--------------------FLGF---------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 CS--------KLDQAVRTP----------------------------------------- FRAP_Mmus_FRAP -------------------V---------------------------------------- DNAPK_Mmus_DNAPK -----------------------KDR--------------------TAKC---------- ATR_Mmus_ATR -----------------------V-M--------------------LLDF---------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP VT--------DQGRST------GKMQ--------------------YCGE---------- B0261.2_Cele_FRAP -------------------K---------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR LL--------EVVKYC-------------------------------------------- TEL1_Scer_ATM -------------------------K--------------------YCDL---------- MEC1_Scer_ATR -----------------------SQE--------------------YAKS---------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -----------------------V-M--------------------LLDF---------- DNAPK_Hsap_DNAPK -----------------------KDR--------------------AAKC---------- TOR_Dmel_FRAP -------------------V---------------------------------------- SMG1_Mmus_SMG1 VK--------QLKEFIQQP----------------------------------------- TRRAP_Mmus_TRRAP II--------ELHKQFRPPITQEIHH--------------------FLDF---------- smg-1_Cele_SMG1 TY--------LLDNLCWPSL---------------------------------------- TOR1_Scer_FRAP -------------------V---------------------------------------- TOR2_Scer_FRAP -------------------I---------------------------------------- TRA1_Scer_TRRAP LT--------TLFKSFKSILQDKLDS--------------------FIRI---------- ATR_Ddis_ATR -----------------------Q-KY----------------EL-YISR---------- DNAPK_Ddis_DNAPK -----------------------KDQ--------------------SHSV---------- SMG1_Ddis_SMG1 -STPIISSAQQQQQQVPPP----------------------------------------- Tor_Ddis_FRAP -------------------V---------------------------------------- TRRAP_Ddis_TRRAP II--------ELHKNYRNAL---------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP -------------------V---------------------------------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP II--------ELHKYYRPTMQPEVSD--------------------RNQL---------- CC1G_00839_Ccin_ATM IL--------DLDL---------------------------------RTPLTEVDEDSED CC1G_08126_Ccin_ATR -----------------------TRA--------------------WADL---------- CC1G_00894_Ccin_FRAP -------------------I---------------------------------------- CC1G_06302_Ccin_PI3K PK--------SFTEVLENP----------------------------------------- CC1G_04234_Ccin_PI4K LH--------KCHEII-------------------------------------------- CC1G_13883_Ccin_PI4K -------------------A---------------------------------------- CC1G_00331_Ccin_TRRAP -------------------------S--------------------YGE----------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -----------------------C-NICDNGIASASAVLKDLEYPYWKTV---------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------------------I---------------------------------------- SMG1_Smoe_SMG1 GS--------PFS----------------------------------------------- GK008_Glam_FRAP -------------------A---------------------------------------- GK009_Glam_PIKK-Unclassified -------------------V---------------------------------------- TRRAP_Hsap_TRRAP --------------------------------VKQIY----KE----------------L SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -----------------------------------------SSS--DANE-R-------- mei-41_Dmel_ATR --------------------------------CHNVL----RS----------------Q CG2905_Dmel_TRRAP --------------------------------VKEIY----TN----------------L CG6535_Dmel_ATM ------------------------------------------------VK-Y-------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -----------------------------------------SSS--DANE-R-------- DNAPK_Mmus_DNAPK --------------------------------KIP------------------------- ATR_Mmus_ATR --------------------------------IQHIM----KS----------------S ATM_Mmus_ATM ------------------------------------------------GL-T-------- C47D12.1_Cele_TRRAP --------------------------------VSQIM----VS----------------F B0261.2_Cele_FRAP -----------------------------------------SNS--NIDQ-K-------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------DVEPSSS----------------L TEL1_Scer_ATM --------------------------------LRNL------------------------ MEC1_Scer_ATR ------------------------------------L----K------------------ ATM_Hsap_ATM ------------------------------------------------GA-I-------- ATR_Hsap_ATR --------------------------------IQHIM----KS----------------S DNAPK_Hsap_DNAPK --------------------------------KIP------------------------- TOR_Dmel_FRAP -----------------------------------------NAT--DINE-K-------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP --------------------------------VKQIY----KE----------------L smg-1_Cele_SMG1 -----------------------------------------TKH--DRND-M-------- TOR1_Scer_FRAP -----------------------------------------HTK--KTST-R-------- TOR2_Scer_FRAP -----------------------------------------HGF--TSSE-K-------- TRA1_Scer_TRRAP --------------------------------IIQIY----KN----------------T ATR_Ddis_ATR --------------------------------IRSI------------------------ DNAPK_Ddis_DNAPK --------------------------------QAA------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -----------------------------------------NSS--VIPE-K-------- TRRAP_Ddis_TRRAP -----------------------------------------ESEIQPFLN-IVLKLYTDL ATMa_Spur_ATM ------------------------------------------------GP-E-------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ----------------------------------EDD----F------------------ FRAP_Spur_FRAP -----------------------------------------SSQ--DVSE-K-------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --------------------------------F--------------------------- CC1G_00839_Ccin_ATM EQATPSRKGTPLDSDDDDAPSPGTFAQKRRRNDKDV------------------------ CC1G_08126_Ccin_ATR --------------------------------MEEII----P------------------ CC1G_00894_Ccin_FRAP -----------------------------------------HSQ--NINE-A-------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K --------------------------------------------------------FSDL CC1G_13883_Ccin_PI4K -----------------------------------------SRV--HCN----------- CC1G_00331_Ccin_TRRAP -----------------------------------------T------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR --------------------------------VLKL------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -----------------------------------------ESA--DVSD-N-------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -----------------------------------------TSS--SYED-R-------- GK009_Glam_PIKK-Unclassified -----------------------------------------CAH--LLDATT-------- TRRAP_Hsap_TRRAP PKV------------------------------------------------VNRYFENPQ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR S----------------------------------------------------------- CG2905_Dmel_TRRAP PNH------------------------------------------------LTSIFETSN CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR PLM------------------------------------------------F-------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP KTMVIDLTA--SGRAGDMFNIKEHKAPPSTSSDEQVITEYLKTCYYQQTVLLN------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR PQ---------------------------------------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR PLM------------------------------------------------F-------- DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP PKV------------------------------------------------VNRYFENPQ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP PNL------------------------------------------------INQTFYEAG ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP PST------------------------------------------------IEKTFSSSS ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP PYI------------------------------------------------HKTYFLD-- CC1G_00839_Ccin_ATM ---LPQPTMKRAGRTRRQGQIPVKPAQVECAIILSLLLCSHNNPMSSPSTKID------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP VI---------------------------------------------------------- SMG1_Hsap_SMG1 ---------------------------------------------EN------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP DV---------------------------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ---------------------------------------------IN------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ---------------------------------------------EN------------- TRRAP_Mmus_TRRAP GI---------------------------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP KA---------------------------------------------------------- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ---------------------------------------------QQ------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP SASLSTTTTAISPTTTTTTTPATATTPATTTATGNTITTPPPATPP-------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP VI---------------------------------------------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ---------------------------------------------DLRFHGVQQ--ATLS CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ---------------------------------------------NLRLHPCQAITSSVA GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------KLV--------------------------------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------MGY--------------------------------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------KLV--------------------------------------- TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------TTTTTTATATAITPT--------------------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -----------------------STTATAISPTSSTTTTTTATTAAAATIATTTATTTIT ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K DLYVT-----CQ------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------SP---------------------------- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ATYVYFLQHGCEKVAVESALC--------------------------------------- GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------PENTVPPPEMV---GMI-----TT--IAVKV----N-----PER---- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -------K----GGI-------------------L--AIASLI----G-----VEG---- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------WVTDLKD---LNLEVLLSE----SYSVRTIH----V-----EKA---- CG6535_Dmel_ATM -------FGDRILSL-------------------L--E-KGIY----SSVSYVRDL---- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -------K----GGI-------------------L--AIASLI----G-----VEG---- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ----------------------------------------VNV-----------NGS--Q ATM_Mmus_ATM -------YGADCSNI-------------------L--L-KDIL----SVRKYWCEV---- C47D12.1_Cele_TRRAP -----------------------------------------------------GT----- B0261.2_Cele_FRAP -------R----AGI-------------------Y--LIVCLA----E-----TH----- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM -----------------------------------------TV-----------STTNKL MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -------YGADCSNI-------------------L--L-KDIL----SVRKYWCEI---- ATR_Hsap_ATR ----------------------------------------VNV-----------SG---- DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP -------K----GGA-------------------L--AMKCLI----N-----CEG---- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------PENTVPPPEMV---GMI-----TT--VAVKV----N-----PER---- smg-1_Cele_SMG1 -------K----TLA-------------------G--KVIRLV----G-----VLL---- TOR1_Scer_FRAP -------V----GAV-------------------L--SIDTLI----S-----FYA---- TOR2_Scer_FRAP -------I----GGI-------------------L--AVDTLI----S-----FYL---- TRA1_Scer_TRRAP ------------EQGDLDSPKEPQADELL-D----EF----SK----N-----DEE---- ATR_Ddis_ATR -----------------------------------------LP-----------ELINSH DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -------I----GGI-------------------M--AIDELI----D-----VDY---- TRRAP_Ddis_TRRAP PPLPPYMI----KSI-------------------E--SFK-------------------- ATMa_Spur_ATM -------FGADCCSI-------------------I--T-RDVL----GCQKYWHEL---- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP -------K----GGI-------------------L--AIVSLI----G-----IDG---- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------PGTPAPDPMNI---QLFVDKAGFS--CQTII----T-----IQQ---- CC1G_00839_Ccin_ATM -----------------------------------------------------DN----- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP -------F----GGL-------------------L--GIERLL----E-----LDL---- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------AP----SGP-------------------Y--SIS-------------------- CC1G_13883_Ccin_PI4K ----------------------------------I--AFGELVVNFPA-----IQL---- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM -------------------------------------------------------K---- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -----------------------------------------LL-----------TN---- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------L----GAL-------------------R--AIDVLI----D-----VEL---- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -------L----ASL-------------------W--VMRELI----Q-----SRP---- GK009_Glam_PIKK-Unclassified -------F----GAA-------------------L--AELCVI----G-----GV----- TRRAP_Hsap_TRRAP ED--S--------------ET----------RTHSIIPRGSLSLKV-LAELPIIVVLMYQ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -G----N-----------AT--------------------------RI---G-------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP LDSNS--------------QQ----------QIYNLLPRGILSLKV-LQELPIIVVLMYQ CG6535_Dmel_ATM -K----I-----------NE--------------------------YS---R-------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -G----N-----------ST--------------------------RI---G-------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR G----------------------------------------------------------- ATM_Mmus_ATM -S----Q-----------QQ--------------------------WL---E-------- C47D12.1_Cele_TRRAP -EGKP---------------P----------LKYNMIPSAHQSTKV-LLEVPYLVIFFYQ B0261.2_Cele_FRAP ------------------SG--------------------------NV---I-------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM S----------------------------------------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -S----Q-----------QQ--------------------------WL---E-------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP -SL--TA-----------RK--------------------------GI---S-------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ED--S--------------ET----------RTHSIIPRGSLSLKV-LAELPIIVVLMYQ smg-1_Cele_SMG1 -F----D-----------TE-------------------------S----YPE------- TOR1_Scer_FRAP -YT-ERL-----------PN--------------------------ET---S-------- TOR2_Scer_FRAP -ST-EEL-----------PN--------------------------QT---S-------- TRA1_Scer_TRRAP KDFPS--------------KQSSTEPRFENSTSSNGLRSSMFSFKI-LSECPITMVTLYS ATR_Ddis_ATR L----------------------------------------------------------- DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -D---EN-----------AT--------------------------KI---T-------- TRRAP_Ddis_TRRAP ---------------------------------------------I-LTECPIVVILLFQ ATMa_Spur_ATM -D----Q-----------RT--------------------------WI---E-------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP -D----N-----------AT--------------------------RI---T-------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP AD--G--------------QK----------VQQTILPKGVNSLKV-LAEYPIIVVLMYQ CC1G_00839_Ccin_ATM -STPE---------------N----------RIARDRGILNRLRQF-LKKYPS------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP -EETIES-----------KR--------------------------NH---F-------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ---------------------------------------------N-L------------ CC1G_13883_Ccin_PI4K -GQS--------------IE-------------------------SIM---A-------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM -K----E-----------E----------------------------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR R----------------------------------------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -GES--------------AT--------------------------KT---M-------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -TIS--------------MI--------------------------PL---T-------- GK009_Glam_PIKK-Unclassified --G--TVRDVLTAPLGTDA----------------------------------------- TRRAP_Hsap_TRRAP LYKLN-------------IHNV-V---A-EF---VP--------------LIMN-TIAIQ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP RFANY-------------LRNL-L---P-SN---DP--------------VVM-EMASKA mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP IYKNA-------------VHQE-V---S-EF---IP--------------LILT-TINLQ CG6535_Dmel_ATM ILSYL-------------FEL--N---V-DM---DE--------------V---L-RTRI CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP RFANY-------------LRNL-L---P-SS---DP--------------VVM-EMASKA DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM LFSLY-------------FRLYLK---P-SQ---DI--------------NRV-L-VARI C47D12.1_Cele_TRRAP HFKTA-------------IQTE-A---L-DF---MR--------------LGLD-FLNVR B0261.2_Cele_FRAP RYANY-------------LLKM-L---N-NGNGLDE--------------DTV-KMASKA atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------LI--TP--------------EIAS-AISLG TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM LFSVY-------------FRLYLK---P-SQ---DV--------------HRV-L-VARI ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP PYLNR-------------LRDL-L---L-IN---DV--------------SVM-EIAARS SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP LYKLN-------------IHNV-V---A-EF---VP--------------LIMN-TIAIQ smg-1_Cele_SMG1 -FLIY-------------LGTL-Y---Q-SV---TKKSEETRADIVFSVYFIVGVISQKT TOR1_Scer_FRAP RLAGY-------------LRGL-I---P-SN---DV--------------EVM-RLAAKT TOR2_Scer_FRAP RLANY-------------LRVL-I---P-SS---DI--------------EVM-RLAANT TRA1_Scer_TRRAP SYKQL-------------TSTS-L---P-EF---TP--------------LIMN-LLNIQ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP RLANY-------------LRIG-L---G-FN---DF--------------TVM-LMASKA TRRAP_Ddis_TRRAP LYNSY-------------MSSN-V---P-KF---IP--------------LIIE---TLS ATMa_Spur_ATM LIETV-------------TMAIHH---T-DQ---GV--------------SLD-P-QARA ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP RFANY-------------LRNL-L---P-SN---DV--------------VVM-EMAAKA SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP LYKQN-------------VHNV-V---A-DF---IP--------------LVMN-TIGLQ CC1G_00839_Ccin_ATM ------------------ESSL-L---H-DF---LS--------------CVEG-TLDAL CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP RFYNY-------------VKHL-L---P-NP---DV--------------HLM-MAASKT CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ----------------------------------SP--------------LL-------- CC1G_13883_Ccin_PI4K ALLDI-------------LRDI-PFIDFD-P----------------------------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ----------------------------------------------------D-P-I-S- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ---------------------------G-ST---DS--------------MAL-Y----- ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP KFANC-------------VKRV-L---EEKQ---DP--------------DVL-VRASEV SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP YFEEI-------------ALEL-V---ND-P---SE--------------VII-LTNCVF GK009_Glam_PIKK-Unclassified --APFLSVYACGTALLCMLLGF-G------------------------------------ TRRAP_Hsap_TRRAP VSA----QARQH---------------K--LY--N---KELYADFIA---AQ-------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP IGR----LAMAG---------------D--TF--T----AEYVEFEV---KRAL-EWLGA mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP PTV----TRRN-------------------SP--Q---KEIYVEFMG---AQ-------- CG6535_Dmel_ATM LKCITRTVSLAK---------------D--RVQLH----VDLVEYLPELSSFAL-SAFGA CG4549_Dmel_SMG1 -------------------------------M--T----CS------------------- FRAP_Mmus_FRAP IGR----LAMAG---------------D--TF--T----AEYVEFEV---KRAL-EWLGA DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM IHAVTRGCCSQT---------------D--GL--P----SKFLDLFS----KAI-QYARQ C47D12.1_Cele_TRRAP VPD----EDK-----------------L--KT--N---QIITDDFVS------------- B0261.2_Cele_FRAP LAF----LIATC---------------K--SY--A----AELVDRCL---DHCH-EWLGQ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ASG----FFRYH---------------L--KW--NIIST--------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM IHAVTKGCCSQT---------------D--GL--N----SKFLDFFS----KAI-QCARQ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP LVK----LANMP---------------T--SK--G----ADSFDFDI---KKAF-EVLRG SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP VST----QARQH---------------K--LY--N---KELYADFIA---AQ-------- smg-1_Cele_SMG1 ENR----L-IAT---------------D--TE--NV---EKSLDWII---KV-------- TOR1_Scer_FRAP LGK----LAVPG---------------G--TY--T----SDFVEFEI---KSCL-EWLTA TOR2_Scer_FRAP LGR----LTVPG---------------G--TL--T----SDFVEFEV---RTCI-DWLTL TRA1_Scer_TRRAP IKQ----QQEAREQAESRGEHFTSISTE--II--N---RPAYCDFIL---AQ-------- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 -------PITTS---------------Q--ST--S----SSMLNLPL---KV-------- Tor_Ddis_FRAP LGR----LARSS---------------G--TL--T----AEFVEFEV---TRAL-EWLSG TRRAP_Ddis_TRRAP LQA----PANST---------------V--TH--H----SQYVDFIA---AQ-------- ATMa_Spur_ATM VQSLVAGATIQG---------------A--LP--T----SYLFNFFG----SML-KRIRT ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP IGH----LALAG---------------G--TF--T----PEYVDFEV---KRAL-EWLGG SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP PTQ----QARAS---------------P--NF--N---KEMYVDFIA---AQ-------- CC1G_00839_Ccin_ATM ALN----RVRDV---------------A--LF--A---RETWDGFVG------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP LGK----IAEIG---------------GGVAF--G----ERFMEYEI---PAAI-ELMQP CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K --------RRHK---------------I-------------------------------- CC1G_13883_Ccin_PI4K ----------------------------------------------------SL-SWHG- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM --------------------------------------------VRD----ALI-Q---- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP LGH----IVSTG------------------PQ--T----ADIVESQV---SCAL-KWLR- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP IGR----LINAE---------------G-H----G----IDFVPKLF---VISIDKIKSG GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------DRNEG----RRHAAVLVLRELAISVPTFFF------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------RK-----TEIVRVYLIFASELAVNYNHQLN------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------DRNEG----RRHAAVLVLRELAISVPTFFF------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------EKSSPGLSHILAALNIFLKSLAVNFRKRVC------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP NVPHSQQPKNQQEIDQI----RRLAASHLSRELALATPTAFF------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------EKSSSGLNHILAALTIFLKTLAVNFRIRVC------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------ERQEY----RRHSAVFILRELAIALPTYFY------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP STEKN---SFSSSKPDH----AKHAALLIITALAENCPYLLY------------------ TOR2_Scer_FRAP TADNN----SSSSKLEY----RRHAALLIIKALADNSPYLLY------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------DRIEA----RRHAAVLVLKELAQNAPTLFY------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------ERSTTVISCTLSALNIFSLHVAPDRRHHLC------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------DRQEG----RRHAA---------------------------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------DKQEA----PRYAGVLILKELARNSPTYFH------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -----------AVLSEF----VIAWGTHVRSRLGVSGPASLFYDLCSTSTFFVDQVVDSI CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------------GES----RRFAAVLILKEMADQAPTVFN------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP DST--------K----------VYTGMLLFNDLT-EVETSF------------------- GK009_Glam_PIKK-Unclassified -------------KGCG----EPFSACLPLLEILRADACAFA------------------ TRRAP_Hsap_TRRAP --------------------------------------IKTL------SFLAYI-IR--I SMG1_Hsap_SMG1 -------LV-KQLDNILAAVH--DV-------------LNESS----------------- FRAP_Hsap_FRAP ----Q--QVQPFFDNIFVAVW--DP-----------------K----------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP --------------------------------------IKTL------SFLAYI-VR--I CG6535_Dmel_ATM ----V--HMQEILPKLCE-YHDEDAF----------------R----------------- CG4549_Dmel_SMG1 -------FV-WILDNMLT------L-------------YKQCP----------------- FRAP_Mmus_FRAP ----Q--QVQPFFDNIFVAVW--DP-----------------K----------------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ----E--AGDEILPTLLY-IWTQHRL----------------N----------------- C47D12.1_Cele_TRRAP ------------------------------------AQSRFL------SFVNIM-AKIPA B0261.2_Cele_FRAP ----L--RVNLFFKYIFNAVR--DK-----------------N----------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -----------------------------------------L------FGENAGECV--H TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ----E--LGDEILPTLLY-IWTQHRL----------------N----------------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ----Q--HILTFFEVIFNAIF--DP-----------------K----------------- SMG1_Mmus_SMG1 -------LV-KQLDNILAAVH--DV-------------LNESS----------------- TRRAP_Mmus_TRRAP --------------------------------------IKTL------SFLAYI-IR--I smg-1_Cele_SMG1 --------------------------------------LPNSSISVYNHCLKGF-VL--V TOR1_Scer_FRAP ----Q--YLNSILDNIWRALR--DP-----------------H----------------- TOR2_Scer_FRAP ----P--YVNSILDNIWVPLR--DA-----------------K----------------- TRA1_Scer_TRRAP --------------------------------------IKAT------SFLAYVFIR--G ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 -------GK-ESIETLFRNRF--HP-----------------K----------------- Tor_Ddis_FRAP ----V--HASSFVDLIWVALK--DP-----------------K----------------- TRRAP_Ddis_TRRAP --------------------------------------VKTL------YLLAYV-LK--W ATMa_Spur_ATM ----K--LGEESLTCLLL-AWRSNT-----------------A----------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --------------------------------------IKTL------SFLAYI-IK--I CC1G_00839_Ccin_ATM -------------------LW--GVKDKRLKEKILIVLRALF------PFIL---VEEPV CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----P--HIGIVFDNILLPLR--DP-----------------R----------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ASST-------------------------------------------------------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----V--HVPEFVDAIWIALR--DP-----------------R----------------- SMG1_Smoe_SMG1 -------LK-REIET--------------------------------------------- GK008_Glam_FRAP ---AIDISSEEFLEPIWHVIT--ET-----------------RN---------------- GK009_Glam_PIKK-Unclassified ----A--HRAASSANPWLPPA--DP-----------------A----------------- TRRAP_Hsap_TRRAP Y-QELVTKYSQQ----MVKGML----------------QLL-------SN--CPAETAH- SMG1_Hsap_SMG1 ---------------------------------------------------------KLL FRAP_Hsap_FRAP ---------------------------------------------------------QAI mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP F-QEVVIASSLS----VTSGML----------------NLM-------KN--CPKEAAH- CG6535_Dmel_ATM ---------------------------------------------------------DDT CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ---------------------------------------------------------QAI DNAPK_Mmus_DNAPK ----------------ALDLLI----------------KLLQIL----RS-T--RLMDE- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ---------------------------------------------------------DSL C47D12.1_Cele_TRRAP F-MDLIMQNGPL----LVSGTM----------------QML-------ER--CPADLIS- B0261.2_Cele_FRAP ---------------------------------------------------------PAV atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR F-DELVLFWPHC----RSQLED----------------KLK-------ND--CSMTENC- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ----------------ILNTLI----------------RNL-------KD---------- ATM_Hsap_ATM ---------------------------------------------------------DSL ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ----------------ALDLLI----------------KLLQTF----RS-S--RLMDE- TOR_Dmel_FRAP ---------------------------------------------------------PAI SMG1_Mmus_SMG1 ---------------------------------------------------------KLL TRRAP_Mmus_TRRAP Y-QELVTKYSQQ----MVKGML----------------QLL-------SN--CPAETAH- smg-1_Cele_SMG1 A-NTFPNVYAAM----FESTLR----------------AIL-------TN--LPDFNSHE TOR1_Scer_FRAP ---------------------------------------------------------LVI TOR2_Scer_FRAP ---------------------------------------------------------LII TRA1_Scer_TRRAP YAPEFLQDYVNF----VPDLII----------------RLL-------QD--CPSELSS- ATR_Ddis_ATR ---------VSTASISDINQIV----------------KLISYL---IE----------- DNAPK_Ddis_DNAPK ----------------AFGPIK----------------KILHLMSRVLKQGS--IVAES- SMG1_Ddis_SMG1 ---------------------------------------------------------NNI Tor_Ddis_FRAP ---------------------------------------------------------VAI TRRAP_Ddis_TRRAP H-IEQIKQYSDR----FPRSVI----------------QLL-------QN--CPAHSSAI ATMa_Spur_ATM ---------------------------------------------------------QAI ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ----------------MLNLMK----------------KVLQ------------------ FRAP_Spur_FRAP ---------------------------------------------------------QAI SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP Y-QDLVNSYAPQ----MVKGML----------------GLF-------GN--CPSEVAH- CC1G_00839_Ccin_ATM F-QEGTRNGTLN----LVEGLQ----------------KLW-------AT--LSGEADS- CC1G_08126_Ccin_ATR ----------------LTEGLL----------------ALIQMM----FATQSPSIYHY- CC1G_00894_Ccin_FRAP ---------------------------------------------------------LHV CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------KHHAEP----VIVGIG----------------TML-------AG--APGM---- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ----------------LVSSAL----------------RIL-------QD--CPSNGNT- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ---------SYRVQSAVVRNLSRLLAHSFEGDARDIWVKCLDV----FP----------- DNAPK_Smoe_DNAPK --------------------------------------------DKDLD-TN--A----- FRAP_Smoe_FRAP ---------------------------------------------------------QAI SMG1_Smoe_SMG1 ----------------------------------------------------------LS GK008_Glam_FRAP ---------------------------------------------------------SNI GK009_Glam_PIKK-Unclassified ---------------------------------------------------------AFP TRRAP_Hsap_TRRAP -------------LRKELL--------------------------IA--AK--------- SMG1_Hsap_SMG1 QELR-QE-G-----------------------------------------ACCLGLLCAS FRAP_Hsap_FRAP R-----E-GAVAAL------------------------------------RACLILTTQ- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -------------LRKELL--------------------------IA--AR--------- CG6535_Dmel_ATM R-----N-LFFQCV------------------------------------SKSLHSM--- CG4549_Dmel_SMG1 PPVL-EE-C-----------------------------------------SKTLGLI-GF FRAP_Mmus_FRAP R-----E-GAVAAL------------------------------------RACLILTTQ- DNAPK_Mmus_DNAPK -------------FKIGEL---FNKFYGELASKSKLPDTVLEKVY--------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM K-----E-VIIELI------------------------------------QLQIYIH--- C47D12.1_Cele_TRRAP -------------VRREVL--------------------------MA--LK--------- B0261.2_Cele_FRAP R-----I-AGIDAL------------------------------------HVVLTIVSQ- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -------------LRAGLT--------------------------IL--KY--------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR -------------QRRNNI----------------------------------------- ATM_Hsap_ATM K-----E-VIIELF------------------------------------QLQIYIH--- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK -------------FKIGEL---FSKFYGELALKKKIPDTVLEKVY--------------- TOR_Dmel_FRAP R-----E-SAGEAL------------------------------------RAALIVTAQ- SMG1_Mmus_SMG1 QELR-QE-G-----------------------------------------ACCLGLLCAS TRRAP_Mmus_TRRAP -------------LRKELL--------------------------IA--AK--------- smg-1_Cele_SMG1 K-----NFELLIDT------------------------------------V--------- TOR1_Scer_FRAP R-----I-DASITL------------------------------------AKCLSTLRN- TOR2_Scer_FRAP R-----L-DAAVAL------------------------------------GKCLTIIQD- TRA1_Scer_TRRAP -------------ARKELL--------------------------HA--TR--------- ATR_Ddis_ATR ----------------------------------KIPN---------------------- DNAPK_Ddis_DNAPK -------------FGVSEM---TQLFLLQFTCG-KLTQTVRGEII--------------- SMG1_Ddis_SMG1 R-----E-TVLSSL------------------------------------QSILIPDLSD Tor_Ddis_FRAP R-----E-GAVEAL------------------------------------RACLELISE- TRRAP_Ddis_TRRAP R-----K-ELLVTL------------------------------------R--------- ATMa_Spur_ATM R-----D-ELVTFL------------------------------------RLQMSVH--- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP R-----E-AAVSAL------------------------------------RACLELTAQ- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------LRKELL--------------------------IA--AR--------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR --------------MRDSVKIVF---------------CRLVDIGYTLGLW--------- CC1G_00894_Ccin_FRAP R-----E-GAADLL------------------------------------ANCLEIVCS- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -------------LRKEPV--------------------------WP--AK--------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------L---F------------------------------------- AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ----------------------------------LHPD---------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP R-----E-HAVEAL------------------------------------RACLTVIVT- SMG1_Smoe_SMG1 RSLAGKK-G-----------------------------------------AMG------L GK008_Glam_FRAP K-----E-VGFKAI------------------------------------NKFIS---Y- GK009_Glam_PIKK-Unclassified R-----LLTASDTF------------------------------------QVLLTCR--- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 LSYEAEK---IFKWI-F--------S---K--FSS-----------------SAKD---- FRAP_Hsap_FRAP --REPKEMQ-KPQWY-R--------H---T--FEEAEKGFDETLA---KEKGMNRD---- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ---YLKMDMCDFNTLGVPVHEKWPQTLLRL--KTI------------------------- CG4549_Dmel_SMG1 INRKSYP---IYEEFIV--------K---N--Y-K-----------------SSKR---- FRAP_Mmus_FRAP --REPKEMQ-KPQWY-R--------H---T--FEEAEKGFDETLA---KEKGMNRD---- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ---HPQGARAPEEGAY--ESMKWKSILYNL--YDL------------------------- C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP --REAK--NK-TEWF-K--------K---C--FDEALEGQPNPS-------QKDDL---- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ---HPKGAKTQEKGAY--ESTKWRSILYNL--YDL------------------------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP --RESTKQSSEPQWY-R--------I---C--YDEANGSFNADLGSSKDQKGVTRD---- SMG1_Mmus_SMG1 LSYEAEK---IFKWI-F--------S---K--FSS-----------------SAKD---- TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP --RDPQ--L-TSQWV-Q--------R---L--ATSCEYGFQV-----------NTL---- TOR2_Scer_FRAP --RDPA--L-GKQWF-Q--------R---L--FQGCTHGLSL-----------NTN---- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 TINNTKE----------------------------------------------------- Tor_Ddis_FRAP --RESR--L-RLQWY-Q--------K---I--YDEAQKSFKQNG----------SP---- TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ---HPKGVMTEEQGAYAGDFDQWKNQLTSL--YEE------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP --RETKEMQ-KPQWY-K--------Q---T--YEEAEKGFEETGK---GEKGLNRD---- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP --RERQ--TR-NPYL-Y--------K---I--LQDAQAGLKS-----------SQP---- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --RETR--WR-VRWY-Y--------R---M--FEATQDGLGKN----------ATV---- SMG1_Smoe_SMG1 VEAEVVS---LLK------------------------------------------F---- GK008_Glam_FRAP --QKKA--TK-HDVL-V--------R---L--ITMIRAALDGK-------NISEQL---- GK009_Glam_PIKK-Unclassified --RARKLAD-ADSLM-C--------R---LSDVQAV-------------------TDRIN TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 -----------------------EVK---LLYLCATYKALET--VGEKKAFSSVMQLVMT FRAP_Hsap_FRAP -----------------------DRIHGALLI------------LNE------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 -----------------------MQK-----YMIMALRATLS--CDTKCELHMYADKIML FRAP_Mmus_FRAP -----------------------DRIHGALLI------------LNE------------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP -----------------------DRWHAVALI------------LNE------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP -----------------------DRIHGGLVV------------FNE------------- SMG1_Mmus_SMG1 -----------------------EVK---LLYLCATYRALET--VGEKKAFSSVMQLVMT TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -----------------------ECIHASLLV------------YKE------------- TOR2_Scer_FRAP -----------------------DSVHATLLV------------FRE------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ---------------------------------------------------------NIE Tor_Ddis_FRAP -----------------------ESIHGSLIT------------VSE------------- TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP -----------------------DRAHGALLI------------INE------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP -----------------------EVIHGSLAA------------YRE------------- CC1G_06302_Ccin_PI3K -----------------------------------LIADNKPLTIPYRTPF-KAF----- CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ----------------------------AFII------------LTQ------------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -----------------------ESIHGSLLA------------VGE------------- SMG1_Smoe_SMG1 -----------------------D-----LLLLLMSVRANAA--------E-SQVQKVKS GK008_Glam_FRAP -----------------------I----ALHL------------LLN------------- GK009_Glam_PIKK-Unclassified GVAAAELRNATVLVGLFSACIAPD------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 SLQSILENVDTPE--LLCKCVKCILLVARCYP---------------------------- FRAP_Hsap_FRAP --------------------------LVRISSME---------GERLREEMEEIT---QQ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM --------------------------VNVEIRKNSWARCKNALLS--------------- CG4549_Dmel_SMG1 LLKDFLENAESAD--IFIVVSNTLVQFAASYA---------------------------- FRAP_Mmus_FRAP --------------------------LVRISSME---------GERLREEMEEIT---QQ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM --------------------------LVNEISHI---------GSRGKY----------- C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP --------------------------LLRISDQR---------FELIRCESSQFI---KQ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM --------------------------LVNEISHI---------GSRGKY----------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP --------------------------LFRCANAT---------WERRYTSLKTLF----P SMG1_Mmus_SMG1 SLQSILENVDTPE--LLCKCVKCILLVARCYP---------------------------- TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP --------------------------ILFLK----------------------------- TOR2_Scer_FRAP --------------------------LLSLK----------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 YFYNMII--DENNYIL---KLLLLNIINDTKRN--------------------LVVYNYN Tor_Ddis_FRAP --------------------------LLRNT----------------------------- TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM --------------------------LVREWRQE---------GSKLKL----------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP --------------------------LIRTSSRE---------GERLRQEMEEVS---QQ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP --------------------------LLLHAG---------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K --------------------------LF------------------------------PA CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------------------------LLRNTG---------------------------- SMG1_Smoe_SMG1 IINFVLEKSDPF------------------------------------------------ GK008_Glam_FRAP --------------------------ML------------------------------NL GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP QLVHDKYCKDLMG-------FGTKP------RHITPFTSFQAVQPQQSNALVGLLGYS-S mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP QLVHDKYCKDLMG-------FGTKP------RHITPFTSFQAVQPQQPNALVGLLGYS-S DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP KFL-----KEDE-------EEG-------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP KTQHNKFLEASSSSSMGSQLNTLVP------RLKVPFID--------------KLGSTQT SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 Q------------------------------QH--------------------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP QTQHEHSFRDLGS-------SSNKAKSPTGPQ--------------LGHNQYVQRALA-S SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K IHGLYRALISTSYTWTLSHWNTLT------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -------HQGLMGFGTSPSPAKSTLVESRC------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -------PQGLMGFGTSPSPAKSTLVESRC------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP -------VEW------LVLTKQQTIVESVT------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP HLGEGEHHKG------VAKFASHNVLESAY------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP -------PLSLVATGIQPK---PRITESRY------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------LGLQRL------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------SVKDKS------------------------------ GK009_Glam_PIKK-Unclassified -----------------------------SLAALVANRGSHFCHLAAGLGLPNQVEGQRL TRRAP_Hsap_TRRAP -------------------------------------------------HILTTE----- SMG1_Hsap_SMG1 -------------------------------------------------HIFSTN----- FRAP_Hsap_FRAP -----------------------------------------------CRDLMEEK----- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -------------------------------------------------HIFATD----- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 -------------------------------------------------ETFECH----- FRAP_Mmus_FRAP -----------------------------------------------CRDLMEEK----- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -------------------------------------------------YFTSGE----- B0261.2_Cele_FRAP -----------------------------------------------ARKLVLER----- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -------------------------------------------------KKLHNS----- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP -----------------------------------------------AQEILQEH----- SMG1_Mmus_SMG1 -------------------------------------------------HIFSTN----- TRRAP_Mmus_TRRAP -------------------------------------------------HILTTE----- smg-1_Cele_SMG1 -------------------------------------------------MRF-------- TOR1_Scer_FRAP ------------------------------------------------DPFLNQV----- TOR2_Scer_FRAP ------------------------------------------------APYLRDK----- TRA1_Scer_TRRAP -------------------------------------------------HILSTN----- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 -------------------------------------------------QLPIQNTSSPN Tor_Ddis_FRAP ------------------------------------------------GDFMLSK----- TRRAP_Ddis_TRRAP -------------------------------------------------HILSSD----- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP -----------------------------------------------CLELMQEN----- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------------------------------------------HILGTD----- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR -------------------------------------------------M---------- CC1G_00894_Ccin_FRAP -------------------------------------------------MFMQEN----- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -----------------------------------------------CSASAITR----- CC1G_00331_Ccin_TRRAP -------------------------------------------------I---------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------------------------------------------------EFMMSR----- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -----------------------------------------------IADYFQEN----- GK009_Glam_PIKK-Unclassified GSVSEVSKSILDTLYAHDTLRKLSAFTNRIYMKAYKRFVLIHVVFAYFDDWLHAD----- TRRAP_Hsap_TRRAP --------LR---------------------------------------------NQFIP SMG1_Hsap_SMG1 --------FR-------------------------------------------------- FRAP_Hsap_FRAP --------FD-------------------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP --------LR---------------------------------------------QKFIP CG6535_Dmel_ATM ---------------NNKFSDPFIKMSALAMYIVL------------------------- CG4549_Dmel_SMG1 --------FT-------------------------------------------------- FRAP_Mmus_FRAP --------FD-------------------------------------------------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ---------S-SGSRNIAVKENLI--------DLMADICYQLFDADTRSVEIS------- C47D12.1_Cele_TRRAP --------MK---------------------------------------------SKFFP B0261.2_Cele_FRAP --------FP-------------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR --------I--------------------------------------------------L TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ---------S-SGFRNIAVKENLI--------ELMADICHQVFNEDTRSLEIS------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP --------YT-------------------------------------------------- SMG1_Mmus_SMG1 --------FR-------------------------------------------------- TRRAP_Mmus_TRRAP --------LR---------------------------------------------NQFIP smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP --------FD-------------------------------------------------- TOR2_Scer_FRAP --------YD-------------------------------------------------- TRA1_Scer_TRRAP --------YK---------------------------------------------KLFLP ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 TPSSTTTTT--------------------------------------------------- Tor_Ddis_FRAP --------FK-------------------------------------------------- TRRAP_Ddis_TRRAP --------FK---------------------------------------------SKFIV ATMa_Spur_ATM ---------KGAGKRDVNFKQDLV--------ELAADVCHQIFNAGLVSYEVSLQGSQVP ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP --------FD-------------------------------------------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --------LR---------------------------------------------NKFVP CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP --------FL-------------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K --------LN-------------------------------------------------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------YK-------------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP --------YS-------------------------------------------------- GK009_Glam_PIKK-Unclassified --------YG-------------------------------------------------- TRRAP_Hsap_TRRAP CMD-----------------KLFDESI-------------LIGSGY----------TARE SMG1_Hsap_SMG1 ------------------------DTV-----------DILVGWH----------I--DH FRAP_Hsap_FRAP ------------------------QVC-----------QWVLKC----------RN---- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP SIE-----------------QLFDEDL-------------LIGKGV----------T-LD CG6535_Dmel_ATM ---------------------WHLE----------------------------------T CG4549_Dmel_SMG1 ------------------------DVV-----------DIVIGWQ----------L--EA FRAP_Mmus_FRAP ------------------------QVC-----------QWVLKC----------RS---- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM --------------------QSY------------------------------------- C47D12.1_Cele_TRRAP MLP-----------------RLIAEEV-------------VLGTGF----------TAIE B0261.2_Cele_FRAP ------------------------KIL-----------DCVRQIIPLANKTSSTKQ---- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR DQA-----------------LFIDELF-------------ATFNSL----------TAKK TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM --------------------QSYT------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------SIC-----------DNVLEQ----------RT---- SMG1_Mmus_SMG1 ------------------------DTV-----------DILVGWH----------I--DH TRRAP_Mmus_TRRAP CMD-----------------KLFDESI-------------LIGSGY----------TARE smg-1_Cele_SMG1 ----SDQLNEKPH----------------------------------------------- TOR1_Scer_FRAP ------------------------QMC-----------LNCIAY----------EN---- TOR2_Scer_FRAP ------------------------DIY-----------KSTMKY----------KE---- TRA1_Scer_TRRAP KLD-----------------YLFDERI-------------LIGNGF----------TMHE ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 --------------------------TTSTKPSKRGDKERERGR-----------RNKDK Tor_Ddis_FRAP ------------------------DIC-----------ETVLKY----------KD---- TRRAP_Ddis_TRRAP YLD-----------------LLLDEK-------------IILGTS----------RTSYE ATMa_Spur_ATM STS-----------------RLMS------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------IVC-----------QQVLKF----------CG---- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP SID-----------------KLFEEHV-------------LVGSGW----------TSKE CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------DTA-----------EAILRF----------KS---- CC1G_06302_Ccin_PI3K --------------------------------------KNSYTWN--------------- CC1G_04234_Ccin_PI4K --PRLTAIMGDVAIEQGRAEEDFDDR-------------TAVG------------PRSED CC1G_13883_Ccin_PI4K ------------------------QLC-----------ADII------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------EVL-----------DIAFKF----------RD---- SMG1_Smoe_SMG1 --------------------------------------EAPVRWH--------------- GK008_Glam_FRAP ------------------------SFF-----------SLVANI----------FR---- GK009_Glam_PIKK-Unclassified ------------------------RVC-----------AELVSS----------YSS--- TRRAP_Hsap_TRRAP -------------TL-------------------RPL-AY---------------STLAD SMG1_Hsap_SMG1 -------------TQ-------------------KP-SLTQQVSG--------WL----- FRAP_Hsap_FRAP --------------S-------------------KNSLIQMTILN--------LL---P- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -------------SI-------------------RPL-AY---------------STLAD CG6535_Dmel_ATM KKADENGEGDAPKKIPKPADKMETIFSLIDKKENT-----FND-V--------WLAIFTE CG4549_Dmel_SMG1 -------------GQ-------------------PT-DLKTHCAQ--------VL----- FRAP_Mmus_FRAP --------------S-------------------KNSLIQMTILN--------LL---P- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM VTQRESTDYSVPCKRRKIDVGWEVIKDYLQKSQSD-----FDLVP--------WLQITTR C47D12.1_Cele_TRRAP -------------HL-------------------RVF-MY---------------QMLAD B0261.2_Cele_FRAP --------------Q-------------------SSIYLNTVLMQ--------LL---P- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -------------ST-------------------NHM-TF---------------PKLLN TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM TTQRESSDYSVPCKRKKIELGWEVIKDHLQKSQND-----FDLVP--------WLQIATQ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP --------------S-------------------KSPYVQQALLQ--------IL---P- SMG1_Mmus_SMG1 -------------TQ-------------------KP-SLTQQVSG--------WL----- TRRAP_Mmus_TRRAP -------------TL-------------------RPL-AY---------------STLAD smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP --------------H-------------------KAKMIREKIYQ--------IV---P- TOR2_Scer_FRAP --------------Y-------------------KFDVIRREVYA--------IL---P- TRA1_Scer_TRRAP -------------TL-------------------RPL-AY---------------STVAD ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 -------------IN-------------------EK-QLQQQQLQ--------QL----- Tor_Ddis_FRAP --------------H-------------------RDKLVKKTVLA--------LF---P- TRRAP_Ddis_TRRAP -------------SL-------------------RSMA----------------YGSLAD ATMa_Spur_ATM SQMRLTSQVTTPSKRRRLESGWELLREYISQPLQH-----ASIIP--------WLQLLAA ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP --------------S-------------------RNPLIQQILLN--------LL---P- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------SL-------------------RPL-AY---------------STLAD CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP --------------S-------------------RDPLVRRMVIT--------MI---P- CC1G_06302_Ccin_PI3K --------------------------------------------E--------------- CC1G_04234_Ccin_PI4K -------------DL-------------------APPA----------------VSAR-- CC1G_13883_Ccin_PI4K ------------------------------------HKDGLDTEE--------IFYAQA- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------------H-------------------RDRLVRRSITS--------LL---P- SMG1_Smoe_SMG1 --------------------------------------------SELQLAVVQA------ GK008_Glam_FRAP --------------S-------------------KTSEGRMLVAS--------II---S- GK009_Glam_PIKK-Unclassified ----------------------------------SPSSLQHNI----------------- TRRAP_Hsap_TRRAP LVHHVRQHL-------------PLSD---------------------------------- SMG1_Hsap_SMG1 --QSLE-PF-------------WVAD---------------------------------- FRAP_Hsap_FRAP ---RLA------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP LAHHVRQSL-------------NIDV---------------------------------- CG6535_Dmel_ATM ILQLSSVIL-------------NVAN---------------------------------- CG4549_Dmel_SMG1 --EQLT-PF-------------FSKQ---------------------------------- FRAP_Mmus_FRAP ---RLA------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM LISKYPSSL-------------PNCE---------------------------------- C47D12.1_Cele_TRRAP LLHHMRNSI-------------DYEM---------------------------------- B0261.2_Cele_FRAP ---RIC------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR EIQHFLQDHGKVLIMHKELRQKPVQW---------------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM LISKYPASL-------------PNCE---------------------------------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ---RLA------------------------------------------------------ SMG1_Mmus_SMG1 --QSLE-PF-------------WVAD---------------------------------- TRRAP_Mmus_TRRAP LVHHVRQHL-------------PLSD---------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ---LLA------------------------------------------------------ TOR2_Scer_FRAP ---LLA------------------------------------------------------ TRA1_Scer_TRRAP FIHNIRSEL-------------QLSE---------------------------------- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 --QL-------------------------------------------------------- Tor_Ddis_FRAP ---RLA------------------------------------------------------ TRRAP_Ddis_TRRAP FIHNMRNEL-------------NINQ---------------------------------- ATMa_Spur_ATM IVTKYPKDL-------------PEEE---------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ---RLA------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP LVHHVRQQL-------------PLQH---------------------------------- CC1G_00839_Ccin_ATM ---RWGTNGL------------KLSTLRLQIIRAGDPRNDTSNPFIASTFRSGWDFDIDQ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ---TLA------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ---FLA------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ---RIA------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ---LFA------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------LSLAVQL----------------------------------------- SMG1_Hsap_SMG1 ------------LAFSTTL----------------------------------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------LIKAVNL----------------------------------------- CG6535_Dmel_ATM ------------YQMALTTV---------------------------------------- CG4549_Dmel_SMG1 ------------IDFSYG------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------LSPLILIL---------------------------------------- C47D12.1_Cele_TRRAP ------------ITHVIFV----------------------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------LIIYLEL----------------------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------LSPLLMIL---------------------------------------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------LAFSTTL----------------------------------------- TRRAP_Mmus_TRRAP ------------LSLAVQL----------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------IEKTIKI----------------------------------------- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ---------------QQQLDHEGSSLYLPFSSLLSFIKPDKQQQPQQSQQSQLNEIDQMV Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------ISKVVAI----------------------------------------- ATMa_Spur_ATM ------------YALFVSAL---------------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------LSMAVHL----------------------------------------- CC1G_00839_Ccin_ATM ALAWGILELQADVAKQLFM----------------------------------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ----------------------------------------------------------FA SMG1_Hsap_SMG1 ---------------------------------------------L-------------G FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ----------------------------------------------------------FS CG6535_Dmel_ATM -----------------------------------------------------------A CG4549_Dmel_SMG1 --------------------------------------------LL-------------D FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM -----------------------------------------------------------Y C47D12.1_Cele_TRRAP ----------------------------------------------------------FC B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ----------------------------------------------------------SC atl-1_Cele_ATR ---------------------------------------------IDDANDKFGLLENFS TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----------------------------------------------------------S ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ---------------------------------------------L-------------G TRRAP_Mmus_TRRAP ----------------------------------------------------------FA smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ----------------------------------------------------------YT ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 RPKSLPKDDNDSDNFNIRVLEYNLKLLIKIYFKVSMYQDSIKTHIF-------------D Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ---------------------------------------------Y-------------S ATMa_Spur_ATM -----------------------------------------------------------H ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----------------------------------------------------------FS CC1G_00839_Ccin_ATM ----------------------------------------------------------FA CC1G_08126_Ccin_ATR ----------------------------------------------------------DV CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ----------------------------------------------------------LS AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ----KN----------------------IDDES-----LPSSIQTMSCKLLLN-----L- SMG1_Hsap_SMG1 ----QFLEDMEAYAEDLSHVASGE---SVDEDV-----PPPSVSLPKLAALLR-----VF FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ----KN----------------------VHDES-----LAVGIQTMSCKLLLN-----L- CG6535_Dmel_ATM EIMQM---------------------------YGNAKNL-----RNLRLCLAHLLTKEQ- CG4549_Dmel_SMG1 ----QFVEDITTLEEG-----------------------EPANTAERVGAFVG-----AF FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM QLLPQ---------------------------QRRGERI-----PYVLRCLKE-----V- C47D12.1_Cele_TRRAP ----RT----------------------LHDPN-----NSSQVQIMSARLLNS-----L- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ----LL----------------------LLDLS-----TNHDIHEFPARLCMT-----A- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ---------------------------------------------MKNDTIF-------- ATM_Hsap_ATM QLLPQ---------------------------QRHGERT-----PYVLRCLTE-----V- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ----QFLEDMEAYAEDLSHVASGE---SVDEDV-----PPPSVSLPKLAALLR-----VF TRRAP_Mmus_TRRAP ----KN----------------------IDDES-----LPSSIQTMSCKLLLN-----L- smg-1_Cele_SMG1 -------------------------------------------------LAEE-----M- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ----GY----------------------LLDES-----LALTVQIMSAKLLLN-----L- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ----LYIQINQAISEQQRQLQEKEKESKTSKPI-----PQPIIS--------L-----VI Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ----RH----------------------LHDQT-----NPVSIQIMSVKLIIS-----L- ATMa_Spur_ATM NLQAH---------------------------SKRSQLQ-----SHVLRCLQC-----I- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----KN----------------------VHDES-----LPCNIQTMSCKLLLN-----L- CC1G_00839_Ccin_ATM ----ES----------------------MH------------------------------ CC1G_08126_Ccin_ATR ----VE----------------------PDDEI-----QP-----SPGKLRNS------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ----AL----------------------LFNTS-----LGFNLHILFAKVIFG-----L- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM -------------------------------------------------C---------- ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 --------------------------------------------------LRR-----VF GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP VD-CIRS---K-SEQESG-NGRDV-L---------------------------------- SMG1_Hsap_SMG1 ST---------------------------------------------------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP VD-CLRH---H-SETEPQ-RSKAL-L---------------------------------- CG6535_Dmel_ATM EL-LHS----------KS-IREDFLG---------------------------------- CG4549_Dmel_SMG1 NT---------------------------------------------------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK --------------------------ELLGVLGEVH---P----------SEMINHSE-- ATR_Mmus_ATR --------------------------------------QNEAKDS--------------- ATM_Mmus_ATM AL-CQGK---K-SNLESS-QKSDL-L---------------------------------- C47D12.1_Cele_TRRAP AE-SLCK---M-DSHD---TTRDL-L---------------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM RT-SLAR---GNSG---------------------------------------------- atl-1_Cele_ATR SEICMRR---I-KHSIQS-THTDC-L---------------------------------- TEL1_Scer_ATM --------------------------------------LSENRLS--------------- MEC1_Scer_ATR ---------------------SKT-VSALALLLEYN-------------PFLLVMKDSN- ATM_Hsap_ATM AL-CQDK---R-SNLESS-QKSDL-L---------------------------------- ATR_Hsap_ATR --------------------------------------SHEAKGS--------------- DNAPK_Hsap_DNAPK --------------------------ELLGLLGEVH---P----------SEMINNAE-- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ST---------------------------------------------------------- TRRAP_Mmus_TRRAP VD-CIRS---K-SEQESG-NGRDV-L---------------------------------- smg-1_Cele_SMG1 VR-IIRP---D-IKKNGLGNMREL-K---------------------------------- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP VE-RILKLGKE-NPQEAP-RAKKL-L---------------------------------- ATR_Ddis_ATR SS-LA---------------------------------IGDSSGD--------------- DNAPK_Ddis_DNAPK --------------------------VVLGLFTEYF---S----------SNMCDRNQ-- SMG1_Ddis_SMG1 PT---------------------------------------------------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP MD-VIQR---K-QDPPEY-KSRSI-I---------------------------------- ATMa_Spur_ATM AA-SQES---R-QKFSQH-TKDQL-S---------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP VE-CIRQ---K-SEQDGA-NAREI-L---------------------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR -----VL---E--------VLAEV-LSGLP---KPFPRLPAPARSISSDQ--------FA CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K -W---------------------------------------------------------- CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP TD-AIVA---K-EVP--Q-TAAKL-L---------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR RS---------------------------------------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 SW---------------------------------------------------------- GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR --------------------ASSWIT---------------------------------- CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ---------------NLFRAFL----GE------LKTQMTSTVREPKFPV---------- ATR_Mmus_ATR -----------------CIEFSHWIIT-------------RLLRIAATPSCHMLHKK--- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM -----------------TI-------S-------------YVLRLFVEKSCERFKVK--- MEC1_Scer_ATR --GNFEIQRLI---DD-----------FLNISVLNYD------N--YHRI---------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -----------------CIEFSNWIIT-------------RLLRIAATPSCHLLHKK--- DNAPK_Hsap_DNAPK ---------------NLFRAFL----GE------LKTQMTSAVREPKLPV---------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -----------------ICFFLFKLIP-------------FLSHKSSTNICSQQHQQLDE DNAPK_Ddis_DNAPK ---------------QLSFIFM----ET------LGGQLRSK--SPESTL---------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR -----------------------------------------------------LDKK--- DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR EAQKFQNPEALKVLRE-----------MVNEVVELTDIVQLYLG--T------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR -------ICEVICSLLF------------------------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM -------TLKLLLAVVP--------------------------------EL--------- MEC1_Scer_ATR -------------------------------------------------------WFMRR ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -------ICEVICSLLF------------------------------------------- DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR NEEFTENLITAIKAMLN------------------------------------------- DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR -------LQKF------------------------------------------------- DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR --------------------------------------------------I--------- AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ---ARKAFCSQLRGLLTQEHIWYSTVGHKSGDYEILKKLGDALAIATDPDVLETLMETVA DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP --MR---MLEVFVLKFH--TIARYQLSAIFKKCKPQSEL--------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP --SK---LLKVFVKKFE--TIAKIQLPLIIQKCKGHAFS--------------------- CG6535_Dmel_ATM --EL---WSQM-----------------A------------------------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK --------LAGCL---K--GLSSLL----------------------------------- ATR_Mmus_ATR -------L---------------------------------------------------- ATM_Mmus_ATM --KL---WIKIWSITFR--GISSGQTQTE------------------------------- C47D12.1_Cele_TRRAP --IE---ILESHVAKLK--TLAVYHMPILFQQYGTEIDYEYKSYE-------------RD B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM --------------------------------------------DEWTKKTVQRVRKEH- atl-1_Cele_ATR --AD---YLDILA-SLL--KLARIQKL--------------------------------- TEL1_Scer_ATM -------M---------------------------------------------------- MEC1_Scer_ATR KLGS---WCKACVEFYG--KPAKFQ----------------------------------- ATM_Hsap_ATM --KL---WNKIWCITFR--GISSEQIQAE------------------------------- ATR_Hsap_ATR -------L---------------------------------------------------- DNAPK_Hsap_DNAPK --------LAGCL---K--GLSSLL----------------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP --MR---MLEVFVLKFH--TIARYQLSAIFKKCKPQSEL--------------------- smg-1_Cele_SMG1 --KRMKLTMALVKMAKSQKM---------------------------------------- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP --MI---IIDSYMNRFK--TLNR-QYDTIMKYYG-RYET--------------------- ATR_Ddis_ATR -------F---------------------------------------------------- DNAPK_Ddis_DNAPK --------IQSCL---K--GLNSLL----------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP --YK---VIESFINKFS--S---------------------------------------- ATMa_Spur_ATM --RE---WSKVWSATIR--TICLHSAEDE------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --MR---MLEVFVLKFH--TIADNQLPVIFDKCRQQQE---------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --SS---MLETCLERLE--GLCTVQ----------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR -------A---------------------------------------------------- AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR EVGK---V---------------------------------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP GAVEAA----------LPGVP--------------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP G----------------------------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK --------------------------------CNFTKS-MEEDPQTSKEIFGFTFKAIRP ATR_Mmus_ATR --------------------------------FK---S---------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP A----EKPGMNIPKDTIRG----------------------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM --------------------------------VK---D---------------------- MEC1_Scer_ATR --------------------------------LTA------------------------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR --------------------------------FK---S---------------------- DNAPK_Hsap_DNAPK --------------------------------CNFTKS-MEEDPQTSREIFNFVLKAIRP TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP GAAEAA----------LPGVP--------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP HK---------------------------------------------------------- ATR_Ddis_ATR --------------------------------LN---D---------------------- DNAPK_Ddis_DNAPK --------------------------------VHFSGDFIASDPKNVQLIYQYVYICLDP SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP AAQEKM----------LPPVSRSISVSSATASS--------------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --------------------------------ADVSQ----------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR --------------------------------ID---G---------------------- AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR --------------------------------AKGDEL---------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -------------------------------NPDVGH----------------------- CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK QIEMKRYAVPLAGLRLLTLHASQFTACLLDNYITLFEVLSKWCSHT-NVELKKAAHSALE ATR_Mmus_ATR ------------------------------KNPAIFG----------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------GSKSLLD----------------------- MEC1_Scer_ATR --------------------------------------HF-------------------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------KSPAIFG----------------------- DNAPK_Hsap_DNAPK QIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKWCAHT-NVELKKAALSALE TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------D-ANVLL----------------------- DNAPK_Ddis_DNAPK ASSTQRFEIPRAAMKIVARHAVLLRQYLAEHSQPFYTRIEHWCNHI-NKLNRDIAFTAVD SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --------------------------------------ALERIRSGSQEVTV-------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ----------------------------------------------------EKLKEKLQ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------R-VSATI----------------------- DNAPK_Smoe_DNAPK ------------LSQSM--------------------------------ALLGSA----- FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -------------YAQLT---------------------------------------LEA CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK SFLRQISFTVAE---DAELHKSRLKY-------------------FMEQFYGIIR-NTDS ATR_Mmus_ATR -------------VLTRE----LLYL-------------------FEDLIYLHKRN-AVG ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM -------------AVSVH----LSFA-------------------LDALIKSDPFK-LKF MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -------------VLTKE----LLQL-------------------FEDLVYLHRRN-VMG DNAPK_Hsap_DNAPK SFLKQVSNMVAK---NAEMHKNKLQY-------------------FMEQFYGIIR-NVDS TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -------------LFFK----ETICL-------------------FKDCIDFIKCLNSSN DNAPK_Ddis_DNAPK SFFQQISKELTSGNRSLEADQSTFKF-------------------FIRKFYSIFE-NNNS SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ----------------------------------------------IHVLSVSLND-FPL DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK SQL--------------------------------------------------------- AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -------------LLIEQLDKSEVSARAVSVRLICEIAAAQWPSDSNRCVER-------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR TAI-M----WSAV-AKWLDM-----GCMTR-QELKRLNIT-TKLLLEVLHMRARPA---- CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK NNK-E----LAIAIRG----------YGLFAGPCKVINAK-D-------------V---- ATR_Mmus_ATR EVM-E----WPVVVSRFLSRLDEHMGCLQP-APLQFMNVQ-N-------------V---- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM MIH-Q----W-------ISLVDKICEYFQSQM---------------------KLSM--- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR HAV-E----WPVVMSRFLSQLDEHMGYLQS-APLQLMSMQ-N-------------L---- DNAPK_Hsap_DNAPK NNK-E----LSIAIRG----------YGLFAGPCKVINAK-D-------------V---- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR NQQEQEKSIFPMVLKTYC-----------------------------------ELSSSVI DNAPK_Ddis_DNAPK SRF-E----LSIAIRG----------CGRFASPVKSFMGEWE-------------L---- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR -----------------------------S-CIYQIM----------------------- DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR INSNTTGNTSSYSKHYQSLDLLVQTEMAFNQYSKNNNNNNNNNNNSEKDKNIEKEKSNSN DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------S----- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -------------------MVDSSSEILFEFFLK-------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------HHLGYLLL----------------------------NEI-LS---LPT CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------DFMYVELIQRCKQMFLTHADASEDHVYQMPSFLQSIASVLLYLDTVPE ATR_Mmus_ATR ------------EFIEVTLL----------------------------MVLIHI---VPT ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------VDKTLTNFI--SIL----------------------------LNLLAL---DTV MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------EFIEVTLL----------------------------MVLTRI---IAI DNAPK_Hsap_DNAPK ------------DFMYVELIQRCKQMFLTQTDTGDDRVYQMPSFLQSVASVLLYLDTVPE TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR DDNSKSID--------EGVI----------------------------IVISSINRLIN- DNAPK_Ddis_DNAPK ------------KSLLNSLFKFSEKLMVVKIENIDEITLHLSSFINAFACILYELNELEF SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -AIELDDGLLETLSSYIQGQLEHSVVPLEQLVHLQQLMLSHWHCHP-THLVP-IL-ALMG CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK VY----------------------------TPVLEHLMVVQ------------ID--SFP ATR_Mmus_ATR -V---------------------------------------FFRRQELLLWQ-IGCALLE ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM -G---------------------------------------IFQVTRTITWTVIDFLRLS MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -V---------------------------------------FFRRQELLLWQ-IGCVLLE DNAPK_Hsap_DNAPK VY----------------------------TPVLEHLVVMQ------------ID--SFP TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR --------------------------------------------LQYGLLVS-ISS-VID DNAPK_Ddis_DNAPK WY----------------------------LDHIEQVLETY------------FI--IFP SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR LKQTEMRSGVVQVLTQS---------LVEILKK----------------------EE--- CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK QYSPKMQLVCCKAIIKL--------------------------------------FLALS ATR_Mmus_ATR HGSPKIRSLAISLLTEL---------FEL-GGL----------------------PA--- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP --------------------------------VPKRRIRRLSIDSVEELEFLASEP---- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM KKENGNTRLIMSLINQLI---LKCHCFSVIDTL----------------------ML--- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR YGSPKIKSLAISFLTEL---------FQL-GGL----------------------PA--- DNAPK_Hsap_DNAPK QYSPKMQLVCCRAIVKV--------------------------------------FLALA TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR NFSPILYSVSIDLWDVLSQYLFLLNDLKLSSFK----------------------Y---- DNAPK_Ddis_DNAPK HLFVKSRDRYFKAVNRL--------------------------------------ISSLF SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -------------------------------------------------------NL--- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP --------------------------------------TAPAAPGPAPSPAPVPAPPPPP SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK EKGPVHWNCISAVVHQGLIRICSKPV------VLQKDV----ESRSDN------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -----------------------------------------STSEDADESGGDPNKLP-- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK AKGPVLRNCISTVVHQGLIRICSKPV------VLPKGP----ESESED------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP --------------------------------------TAPAAPGPAPSPAPVPAPAPPP smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK YHGEYLKILLSRFVKKGLLITFSKPNDSIKNLIT-------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------------------------------TTTTTTTTTSSSTASVSLPPPPP CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP P-PPP-----------------PATP-----VTPAPVPP--------------------- SMG1_Hsap_SMG1 ----------------VVRSIGERFS----PI---RG----------------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ----------------LLKCLA-RMQ----IF---VG----------------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP --------------------------------------PPTKEGKKTSPEAILTAMSTMT B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ----------------VVRSIGERFS----PI---RG----------------------- TRRAP_Mmus_TRRAP PPPPA-----------------PATP-----VTPAPVPP--------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ----------------VLVSIGDIIKYKYATP---SP----------------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ----------------LKRSIPK------------LL----------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP T-PTTPQTMSFASLSTTAATIPPATP-----TTP--APP--------------------- CC1G_00839_Ccin_ATM -----------------------------------------------------PATPCTS CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ----------------I------------------------------------------- CC1G_04234_Ccin_PI4K ------------------TSLDE------------DD----------------------- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ----------------IVP----------------------------------------- GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ---FEK---------------QGE------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ---------------------------------------------ALVNSSGNASLSHIN CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP PPPL-------------------------------------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ---FEK---------------QGE------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ----------------------KEKAEKLKNSIQDNDKESEEFMRKVLEPSDDDHLMPQP ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ----------------ADQQKEKE------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ---VTPGVSSITTAPLSSLFPTRE------------------------------------ CC1G_00839_Ccin_ATM QRKD-------------------------------------------------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ----------------DDQ----------------------------------------- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -KDKED-----------K-------------------------QTFQVTDCRSLV---KT SMG1_Hsap_SMG1 -----------PPITE-----------------------------AYVTDVLYRV---MR FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP APDLKDDISNIQVSASGSQW----------------------IYSVNVAEFRSLV---KT CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 -----------MPTCE-----------------------------CIVKMAVDHLIKIMP FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ----------------------------------------------------------RS ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ----------------------------------------------AIVEARNLV---KY B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ----------------------------------------------------------HR TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 -----------PPITE-----------------------------AYVTDVLYRV---MR TRRAP_Mmus_TRRAP -KDKED-----------K-------------------------QTFQVTDCRSLV---KT smg-1_Cele_SMG1 ------LEETNQMISEMSIELEENGGKWSSASLITIVCDVFNELLILGKDDVKLQ---KG TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP KKEDINDSPDVEMTES--DKVVKNDVEMFDIKNYAPILLLPTPTNDPIKDAFYLY---RT ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 -----------PNLTP-------------------TTTTKMEEEER-------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -KELKDPQS------------LKDKLDGLSSANTTTSSTGEIIILDPVKDTRTLI---KT ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -KDESKPKKYLPTGLTHF-------------------------NNYSVVDCRSLV---KT CC1G_00839_Ccin_ATM ----------------------------------------------KRFRLQNPV---ST CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K -----------------------------------EGSPSSEESLP-AK----------- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP LVCGVKTITW------------------------------------GITSCKAPGEAQ-- SMG1_Hsap_SMG1 CVTAANQVFF------------------------------------SEAVLTAANECVGV FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ----V------------------------------------------------------- CG2905_Dmel_TRRAP LVGGVKTITW------------------------------------GFFNSKFQLTDT-- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------TLHL------------------------------------NTEALVNINELICI FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ASEEV------------------------------------------------------- ATR_Mmus_ATR ----Q------------------------------------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP IMHTCKFVTG------------------------------------QLRIARPS------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ----I------------------------------------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ----Q------------------------------------------------------- DNAPK_Hsap_DNAPK ASGEV------------------------------------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 CVTAANQVFF------------------------------------SEAVLTAANECVGV TRRAP_Mmus_TRRAP LVCGVKTITW------------------------------------GITSCKAPGEAQ-- smg-1_Cele_SMG1 VEESL------------------------------------------------------- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP LMSFLKTIIH------------------------------------DLKVFNPPPNEY-- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP MTSSLRNIFW------------------------------------SLSACPINKPGTGI ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP VVCGVKTITW------------------------------------GVSACKVSTDP--- CC1G_00839_Ccin_ATM LLHNIETQILTVPRCYHLQVLLFFVDRHWSIVHDTLKRQIMDTLIQVQNLED-------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ----V------------------------------------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------FI--PN-K-------QL---------QPKETQIYIKLVKYAM SMG1_Hsap_SMG1 LLG----SLD-----------------------------------PSMTIHCDMVITYGL FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------KLANHE-K-------IF---------GPEIVCSYIDLVYYAM CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 CLLNNFTGLD-----------------------------------PIL---LEQV---LL FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ----------------------QDM--------YH---------CSKERDLFERLLRYGV B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 LLG----SLD-----------------------------------PSMTIHCDMVITYGL TRRAP_Mmus_TRRAP ------------------FI--PN-K-------QL---------QPKETQIYIKLVKYAM smg-1_Cele_SMG1 ------------------------CN--------VLKDLNLSNQSTMEKQAFFN------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------TVAN-P-KLWASVSRVF---------SYEEVIVFKDLFHECI ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP TT-------GAGATTTTTTN--TNNT--------IIPPVRIALPSIEESLLFIKLFKSTV ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------------N--QN-K-------QF---------HPKETAVFIKLVKHAL CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K -------------------------------------------------------T---- CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 -----------------------------------------------------WEV---- GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP QALDIYQVQ---IAG---NGQTYIRV---------------------------------- SMG1_Hsap_SMG1 DQLENCQT-----CGTDYIISVLNLLTLIVEQINTKL----------------------- FRAP_Hsap_FRAP ----------------------------------AFR----------------------- mei-41_Dmel_ATR ------------------------LS----KDWQ----KLIAILRGFKQLEKLILSQSQH CG2905_Dmel_TRRAP EALDIYTIN---VNP---NQQ----R---------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 DQVKRMIS-----LTELQRQSVLYLLLCTVRRLRARL----------------------- FRAP_Mmus_FRAP ----------------------------------AFR----------------------- DNAPK_Mmus_DNAPK ------------------------RTGRWKVPTYKDYVDLFQHLLGCDQ----------- ATR_Mmus_ATR ------------------------PA----STFFSLFLELLQHLVGMDA----------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP MCMDVFVLP---TTR---NQP--------------------------------------- B0261.2_Cele_FRAP ----------------------------------AFP----------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------KEAWSYNLTIGCTSNELVQ----------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------PA----STFFSSFLELLKHLVEMDT----------- DNAPK_Hsap_DNAPK ------------------------RTGKWKVPTYKDYVDLFRHLLSSDQ----------- TOR_Dmel_FRAP ----------------------------------AFN----------------------- SMG1_Mmus_SMG1 DQLENCQT-----CGTDYIISVLNLLTLIVEQINTKL----------------------- TRRAP_Mmus_TRRAP QALDIYQVQ---IAG---NGQTYIRV---------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ----------------------------------SFN----------------------- TOR2_Scer_FRAP ----------------------------------AFD----------------------- TRA1_Scer_TRRAP IGLKFFKDHNEKLSPETTKKHFDISM---------------------------------- ATR_Ddis_ATR -----------------------------MANFIYSLLVLFEKLLKLSS----------- DNAPK_Ddis_DNAPK ---------------------------TANTPFYQVYKDLWYNLLNPTI----------- SMG1_Ddis_SMG1 -----------------------IINTILINEFK-------------------------- Tor_Ddis_FRAP ----------------------------------VFC----------------------- TRRAP_Ddis_TRRAP KCFPIYG----------------------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ----------------------------------AFE----------------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP KALDIYQIQ---ISP---TGQTSIRA---------------------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----------------------------------AYD----------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ----------------------------------RYTAQGRPVSGYFLICCILEIEWTVL CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------LRPFLVKEFAEAV----------------------- DNAPK_Smoe_DNAPK ---------------------------------YKTYSELLR------------------ FRAP_Smoe_FRAP ----------------------------------HFL----------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------------------------------KLD----------------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 PSS--FVEKL-----FIPSSKL-------------------------------------- FRAP_Hsap_FRAP PSA--FTDTQ-----YLQDTMN-------------------------------------- mei-41_Dmel_ATR KIAEHEG----------------------------------------------------- CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 TPS--LVHFI-----FQSNPYM-------------------------------------- FRAP_Mmus_FRAP PSA--FTDTQ-----YLQDTMN-------------------------------------- DNAPK_Mmus_DNAPK ----------MEDFIL----GDETFLFVN---------------SSLKSLN--------- ATR_Mmus_ATR ---DQLK----------------------------------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP QCDRTFQ-TI-----SFD------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ---DQLS----------------------------------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ---DQLK----------------------------------------------------- DNAPK_Hsap_DNAPK ----------MMDSIL----ADEAFFSVN---------------SSSESLN--------- TOR_Dmel_FRAP RAV--FV-EK-----YLQTCVS-------------------------------------- SMG1_Mmus_SMG1 PSS--FVEKL-----FIPSSKL-------------------------------------- TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP PQL--FA-GK-----YLHQIMD-------------------------------------- TOR2_Scer_FRAP PAI--FT-KK-----YLDRIMV-------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ---NQIP----------------------------------------------------- DNAPK_Ddis_DNAPK ---D--TIDKDLNSTI----KKENNNNNNNKNKNNNNNQTLTKEEISKSIK--------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP SRD--FV-LN-----YFNACMN-------------------------------------- TRRAP_Ddis_TRRAP ---------------------G-------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP PKM--FV-TS-----YLEDTVK-------------------------------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP TQT--FT-EH-----FLHKAMA-------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K AQT--MT-EPVVNRATVTEA---------------------------------------- CC1G_00331_Ccin_TRRAP --------------------------------------------------DTLFIEKSRP AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP RDR--FV-TS-----YFTTSMD-------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP PER--FCTTE-----RLQMILT-------------------------------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -ANCQTV-----------------------------RMKEEKE---------VL-EHFAG SMG1_Hsap_SMG1 ---LFL------------------------------RYHKEKE---------VV-AVAHA FRAP_Hsap_FRAP ---HVLS-----------------------------CVK-KE---------KERTAAFQ- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -TSGLIS-----------------------------RSKEEKE---------VL-EHFSG CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ---TKV------------------------------RLRSPGE---------TSYKLLLR FRAP_Mmus_FRAP ---HVLS-----------------------------CVK-KE---------KERTAAFQ- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -QMHSSM-----------------------------RTKDEKD---------AL-ESLAN B0261.2_Cele_FRAP ---TSFT-----------------------------IL-------------QRNAVAAP- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ---HLMQ-----------------------------ILRGKE---------KDRTVAYI- SMG1_Mmus_SMG1 ---LFL------------------------------RYHKEKE---------VV-AVAHA TRRAP_Mmus_TRRAP -ANCQTV-----------------------------RMKEEKE---------VL-EHFAG smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ---NYLE-----------------------------ILT-NAPANKIPHLKDDKPQILI- TOR2_Scer_FRAP ---HYLR-----------------------------YLK-NIDMNA--ANNSDKPFILV- TRA1_Scer_TRRAP -PSLPVS-----------------------------ATKDARE---------LM-DYLAF ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 --------------------------------------KTDVS---------II-ESNLY Tor_Ddis_FRAP ---HLLA-----------------------------ALR-NQ---------NERPTAFI- TRRAP_Ddis_TRRAP ---CNP------------------------------SPQEEKE---------MI-ENFTA ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ---YMLI-----------------------------SLR-RE---------RERSNAFQ- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -ANTQSV-----------------------------RLKEEKE---------VL-EHFAG CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ---------------------------------------E-------------------- CC1G_00894_Ccin_FRAP ---HLLT-----------------------------QLD-KA---------PERNFAFI- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K --------------------------------------A-------------AANK---- CC1G_00331_Ccin_TRRAP VGGALYA-----------------------------LEKP-------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ---HLLA-----------------------------VMR-NP---------SERSTGFA- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ---FYKK-----------------------------MIP-------------TQQELFI- GK009_Glam_PIKK-Unclassified ------SLCAEASGLAALSSLNVTCYLAVCVHALDYT----------------------- TRRAP_Hsap_TRRAP VFTMMNPL------------------------------TFKEIFQTTVPYMVERIS-KNY SMG1_Hsap_SMG1 VYQA--------------------------------------------------VL-SLK FRAP_Hsap_FRAP ----ALGLLSVA--VRS-EFKVYLPRVLDIIRA--------------------------- mei-41_Dmel_ATR --------------------------------------HIDSS-VLAMLP---------- CG2905_Dmel_TRRAP IFLMMHSQ------------------------------NFQEIFSTTINFLVERIY-KNQ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 TCQE--------------------------------------------------TL-LIR FRAP_Mmus_FRAP ----ALGLLSVA--VRS-EFKVYLPRVLDIIRA--------------------------- DNAPK_Mmus_DNAPK ------HL------------------------------LYDEF-IRSVLKIVEKLD-LTL ATR_Mmus_ATR --------------------------------------LYEEP-LSKLLK---------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP VFTTIDHA------------------------------IFREIFEKYMDFLIERIYNRNY B0261.2_Cele_FRAP ----AIGMMMLS--NPD-VHATHIEKTISFISA--------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM --------------------------------------LFDVM-SSELMN---------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR --------------------------------------LYEEP-LSKLIK---------- DNAPK_Hsap_DNAPK ------HL------------------------------LYDEF-VKSVLKIVEKLD-LTL TOR_Dmel_FRAP ----TIGYMAVA--VQS-AIEVHLSSIMTSVKV--------------------------- SMG1_Mmus_SMG1 VYQA--------------------------------------------------VL-SLK TRRAP_Mmus_TRRAP VFTMMNPL------------------------------TFKEIFQTTVPYMVERIS-KNY smg-1_Cele_SMG1 ----SLAKIVKQLPAE-SQVKTRVHQIVFNTETGLFTPKNRDNRMFGHNMIYKDLI-NLV TOR1_Scer_FRAP ----SIGDIAYE--VGP-DIAPYVKQILDYIEH--------------------------- TOR2_Scer_FRAP ----SIGDIAFE--VGS-SISPYMTLILDNIRE--------------------------- TRA1_Scer_TRRAP MFMQMDNA------------------------------TFNEIIEQELPFVYERML-EDS ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------KL------------------------------VYDEI-VSSILSIIKKLD-LQY SMG1_Ddis_SMG1 LFEC--------------------------------------------------IL-SI- Tor_Ddis_FRAP ----ALGEIAMA--VGG-SIKPYLDSIVVMIKQ--------------------------- TRRAP_Ddis_TRRAP SFMMLDQR------------------------------TFQEVSTFILPFLYQRSL-NNP ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ----AVGLLAVA--VKG-NITEHLGKILEIVRS--------------------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP VFNMMHPL------------------------------TFREIFQTTIEYMVERIY-KNY CC1G_00839_Ccin_ATM ------------------------------------------------PDVQSWI-LLNY CC1G_08126_Ccin_ATR ------RR------------------------------LLVESAR--------------- CC1G_00894_Ccin_FRAP ----AIGHTALA--VGS-DMKPFLDPIMDNVRS--------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------ED------------------------------VMLEVWTHKMGFFFEHAQ-KRI AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ---------------------------------------MD------------------- AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----ALGEMAGA--VGC-ALGEYLPAIMNFIRD--------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----PLGEFVIV--IGEKHVKPIFNDLINLITS--------------------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ALQIV------------------------------A-------NSFL-ANPTT------- SMG1_Hsap_SMG1 NIPVL------------------------------ETAYKL---------ILGEMTCALN FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP SLQVI------------------------------A-------NSFL-ANPTT------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 NVPLL------------------------------QQAYKY---------LVDDIDACLE FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK EKQTVGEQE--------DGS-T-ADVWVIPTSDPAA-------NLHP-AKPSD------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP PLQLM------------------------------V-------NTFL-VRNE-------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR --------------------------------------------------ENT------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK EIQTVGEQE--------NGD-EAPGVWMIPTSDPAA-------NLHP-AKPKD------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 NIPVL------------------------------ETAYKL---------ILGEMTCALN TRRAP_Mmus_TRRAP ALQIV------------------------------A-------NSFL-ANPTT------- smg-1_Cele_SMG1 SVLLT------------------------------PTSLNHLQATYT-DLRKIM------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP GLLHV------------------------------A-------QSFL-TSEIT------- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK QKDENDNNSNSNSNNNNNNDQDNNKISIIEYESEIN-------QLKP-VTSKD------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP SLLLI------------------------------P-------QGFL-SVTQMN------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ALQLI------------------------------A-------NSFL-ANLTT------- CC1G_00839_Ccin_ATM AAIAY------------------------------A-------ESHWAGANV-------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP VLLTV------------------------------C-------QFLF-NREST------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP --------------SALFATILVEYLLDRLPEMGS-NVE-LSNLYL-------------- SMG1_Hsap_SMG1 NLLHSLQLPEACSEIKHEAFKNHVFNVDNAKFVVI-FDL-SALTTI-------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ----------------------------------------------LQ------------ CG2905_Dmel_TRRAP --------------SPLFATVLVEYLLNKMEEMGS-NLE-RSNLYL-------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 KLLIT----------------APRSKARKASVLLV-FHL-SALAAL-------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK --------------FSAL-INLVEFCREILPRKHV-GF-FEPWVYS-------------- ATR_Mmus_ATR ----------------------------------------------TLFPF--------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP --------------VPFFASTMLSFLMSRMKLLEVS-ND-KTMLYV-------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ----------------------------------------------HKLPY--------- MEC1_Scer_ATR --------------MNLYEQALTEVLLGKTELLKF-YDTLK-GLYILLYWFTSEYSTFGN ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ----------------------------------------------TLFPF--------- DNAPK_Hsap_DNAPK --------------FSAF-INLVEFCREILPEKQA-EF-FEPWVYS-------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 NLLHSLQLPDACSEIKHEAFQNHVFNIDNANFVVI-FDL-SALTTI-------------- TRRAP_Mmus_TRRAP --------------SALFATILVEYLLERLPEMGS-NVE-LSNLYL-------------- smg-1_Cele_SMG1 --------IDSMSRLKQSEDTPYSDNIRWNESILL-LFF-SSLQSI-------------- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP --------------SPNFAGILLRFLKGKLKDLGNVDFN-TSNVLI-------------- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK --------------IELF-LGLVEFFKLFISKYNT-EL-FVQWIYI-------------- SMG1_Ddis_SMG1 -------------------------SVSNEPTIVV-PNT-TTATTA-------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP --------PTGVQINRVFLEVLTPFLYEKIRNLQP-TDK-PDICMI-------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --------------SATFATILVEYLLERMEEMGT-NQE-RSNLYL-------------- CC1G_00839_Ccin_ATM --------------DALISS---------------------------------------- CC1G_08126_Ccin_ATR --------------------RVFDYILSPSCH-FT-N-DRRIRWLG-------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --------------TSILLGIVLKYLVGRLPLLGE-YDDITAAATI-------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ----------------------KLFKLVFGSVSL-------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -----------------------------------------CEIIKVADTNWNNLSMQLV CG2905_Dmel_TRRAP ----------------------RLFKLVFGSVSL-------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ----------------------FAYELILQSTRLPLISG--------------------- ATR_Mmus_ATR ------------------------------------EAEAYRNIEPVYLNVLLEKLSVMF ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ----------------------KLFKIIFSAIGA-------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------MIGQENYVEEL----RSESLVSLY MEC1_Scer_ATR SIAFLDSSLGFTKFDFNFQRLIRIVLYVFDSCEL-------------------------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------EAEAYRNIEPVYLNMLLEKLCVMF DNAPK_Hsap_DNAPK ----------------------FSYELILQSTRLPLISG--------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ----------------------KLFKLVFGSVSL-------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ----------------------RLFKLSFMSVNL-------------------------- ATR_Ddis_ATR -------------------------------------ALLYNNIVGQFFNVLLP-MSMLL DNAPK_Ddis_DNAPK ----------------------FGKEMISFSKKYPLISG--------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ----------------------KLIKLIFNAIQP-------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----------------------KLFKLVFGSVSL-------------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ----------------------KLFQVVLETLSD-------------------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ----------------------RLFKMAFNAVTT-------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ----------------------FA------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------GNAKNSLIGMWA FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ELESK--CSADR------------------------------------------------ CG2905_Dmel_TRRAP ----------------------FP------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------AKQTSSIIGMYA FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ----------------FYKLLSIA------------------------------------ ATR_Mmus_ATR EDRVL--MRLKS------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ----------------------NG------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM REYIL--LRLSNYKPQLFTVNH-------------------------------------- MEC1_Scer_ATR ----------------------AA------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR EDGVL--MRLKS------------------------------------------------ DNAPK_Hsap_DNAPK ----------------FYKLLSIT------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------GNAKNSLIGMWA TRRAP_Mmus_TRRAP ----------------------FA------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------SCAKSSLIVMMG TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ----------------------FP------------------------------------ ATR_Ddis_ATR NDKDCSKRRE-------------------------------------------------- DNAPK_Ddis_DNAPK ----------------FYKLVQIV------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------TTATTSNTSTAA Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ----------------------NNNSGVGGSGGSNSSGGGGGGGSNSSNNSTNSNTTTNI ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----------------------FA------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ----------------------TG------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ----------------------YP------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -------A--E----------------------NEQMLK--------------------- SMG1_Hsap_SMG1 LSPTVFAL-----------------------------LS--------------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -------V--E----------------------NEQMLR--------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 CKPSILEL-----------------------------LL--------------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK -------V--KNARKIKYFEG--------------------------------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -------SGLH----------------------GDKMLTSYLPE-------------ILK B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM -----------------------------------QFEKNDLEK-------------VDN atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR -------L--E----------------------YAEIQL--------------------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK -------V--RNAKKIKYFEG--------------------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 LSPTVFAL-----------------------------LS--------------------- TRRAP_Mmus_TRRAP -------A--E----------------------NEQMLK--------------------- smg-1_Cele_SMG1 IRPSIFEF-----------------------------FS--------------------- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP -------N--I----------------------NEVVLL--------------------- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -------M--QICKSQKYFNELQQDDNINSVIFNNQIID--------------------- SMG1_Ddis_SMG1 AATTT------------------------------------------------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP DSTCVQQV-----------------------------LS--------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------N--E----------------------NEQMLK--------------------- CC1G_00839_Ccin_ATM ----------------------------------------QAPDVLDAKVWDTILQSVVR CC1G_08126_Ccin_ATR -------P--L----------------------FSYMQE--------------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -------H--T----------------------NESILA--------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP PHLHK------------------IV----NSSME-LAQT--AKEPYNYFL-----LLRAL SMG1_Hsap_SMG1 KNLM--------------------------IVHSDL---AVHFPAIQY-A-----VLYTL FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP PHLHK------------------IV----NRSME-LALI--SEEPYNYFL-----LLRAL CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 TNCR--------------------------AHELKF---WSKYPAAQQ-A-----IFGLL FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK -----------------------IS----PKSLK-HSPE--DTEKYSCFA-----LFAKF ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP Q------------------------------STV-LALT--AREPLNYFL-----LLRAL B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM S------------------------------LNS-AA----------------------- atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------VEFS-YIRG--SRDKNSWFA-----LPDFR MEC1_Scer_ATR KYISL------------------VVDYVCNRTIS-TALD--AP----------------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK -----------------------VS----PKSLK-HSPE--DPEKYSCFA-----LFVKF TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 KNLM--------------------------IVHSDL---AVHFPAIQY-A-----VLYTL TRRAP_Mmus_TRRAP PHLHK------------------IV----NSSME-LAQT--AKEPYNYFL-----LLRAL smg-1_Cele_SMG1 SELP--------------------------LTEYWL---ASNHPEVYHL------FITIF TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP PHLND------------------LI----LNSLK-YSTT--AEEPLVYFY-----LIRTL ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK EQLQQQQDIMDIDDTDNNSNSNNKI----NKKLT-NS-L--EEDKNNCFI-----LFKKY SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP SMIL--------------------------ILLK-LITESKQIDSIQYLL-----LLKTI ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP PHLHK------------------IV----NRSME-LATT--AKDPYNYFL-----LLRAL CC1G_00839_Ccin_ATM R------------------------------INT-AAVC--RAASHATHS-----LLISL CC1G_08126_Ccin_ATR RLLHS------------------RY----DGTIH-GNT-----------TTLDVLLNQSF CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP SHLPK------------------LL----MDCFP-LAAK--ASKPTHYFY-----LLRAL AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP FRSI--GGGSH-DLLY-----------------------QEFLPLLP------------- SMG1_Hsap_SMG1 YSHC--TRHDH----FISSS-LSSSSPSLFDGAVISTVTTATKKHFS------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------RHIH-----------------------LEICSLLM------------- CG2905_Dmel_TRRAP FRSI--GGGSH-DLLY-----------------------QEFLPLLP------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 VVHC--QANHN----FRT------NSSLLRDQELSAENTSPTANSFA------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK GKEV-------------------------------------------------------- ATR_Mmus_ATR ------------DLLK-----------------------AALCHLLQ------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP FRSI--GGGAQ-DILY-----------------------GKFLQLLPN------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM LR--DRGGRSVWLKIL-----------------------GITKSLLT------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------DLLK-----------------------AALCHLLQ------------- DNAPK_Hsap_DNAPK GKEV-------------------------------------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 YSHC--TRHDH----FISSS-LSSSSPSLFDGAVISTVTTATKKHFS------------- TRRAP_Mmus_TRRAP FRSI--GGGSH-DLLY-----------------------QEFLPLLP------------- smg-1_Cele_SMG1 VGHL--KAHDF----YIV------QSDYIVRGDSIGQSIGQTKRDYA------------- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP FRSI--GGGRF-ENLY-----------------------RSIKPILQ------------- ATR_Ddis_ATR -------------EID-----------------------IKLTSIIP------------- DNAPK_Ddis_DNAPK IKEV-------------------------------------------------------- SMG1_Ddis_SMG1 ------------------TPTLSTSSSS-LSPPAST------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP FKSC--TRPDQ----S-----------------------KEITLLFP------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP FRSI--GGGSH-DLLY-----------------------QEFLPLLP------------- CC1G_00839_Ccin_ATM YR---------------------------------------------YTPPSGHIFLSSP CC1G_08126_Ccin_ATR DR--PFSTASR-AVVY-----------------------QAL----G------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP FRAIGVGGGRF-ELLY-----------------------SAVLPLLP------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP N--L---------------L-QG-------------L-NM-LQ-SGLH---KQHMKDLFV SMG1_Hsap_SMG1 I--I---------------L-NL-------------L-GILLK-KDNLNQ---DTRKLLM FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR Q--I-------------------------------------------------------- CG2905_Dmel_TRRAP N--L---------------L-EG-------------L-NR-LQ-SGFH---KQHMRDLFV CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 S--I---------------L-RF-------------LDSVLGQ-AHQLAP---QNLRVLL FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ---------------------------------------------SVK---MKQYKDELL ATR_Mmus_ATR Y--FL-TFVPAG---------------------------YE------S---ALQVRKVYV ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ---L---------------L-QF-------------L-NK-LT-SCQH---RIQMRELFV B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR --------------------------------------------------------DIFQ TEL1_Scer_ATM Y--FALNRKN-------------------------------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR Y--FL-KFVPAG---------------------------YE------S---ALQVRKVYV DNAPK_Hsap_DNAPK ---------------------------------------------AVK---MKQYKDELL TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 I--I---------------L-NL-------------L-GILLK-KDNLNQ---DTRKLLM TRRAP_Mmus_TRRAP N--L---------------L-QG-------------L-NM-LQ-SGLH---KQHMKDLFV smg-1_Cele_SMG1 RKQV---------------V-AL-------------Q-KIINNFGDKLW----------- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP V--L---------------L-QS-------------L-NQ-MI-LTAR---LPHERELYV ATR_Ddis_ATR L--LF-SNVPSSTLFDFSSIILP-------------N-ILFII--NNT---NLTELKVSI DNAPK_Ddis_DNAPK ---------------------------------------------SNF---ISHYKDELL SMG1_Ddis_SMG1 Q--S---------------S-LSLSSSSSAVIAPTTV-GYI------------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP I--I---------------L-ET-------------L-NDLLL-SSSHSTMIPAVQQLLI ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP N--L---------------L-QG-------------L-NQ-LQ-SGLH---KQHMKDLFV CC1G_00839_Ccin_ATM R--V---------------L-QE-------------I-EI-IC-KDIN---IEGPHAPYD CC1G_08126_Ccin_ATR C--LNASPNDERNPQVHTLAISY-------------L-KHSLS--GID---KELL----- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP E--L---------------L-ES-------------L-NR-QL--LAS---EGQTRDMIV AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -ELCLTVPVRL-S----------------------------------------------- SMG1_Hsap_SMG1 -TWALEAAVLM-K----------------------------------------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -ELCLTVPVRL-S----------------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 -QWIQM---LLRE----------------------------------------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK -ASCLTFVLSL-P----------------------------------------------- ATR_Mmus_ATR TNIC-RALVDA-L----------------------------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -ELCLTVPVRL-S----------------------------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -CFATEIEAHH-S----------------------------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ---ALVCCEQL-K----------------------------------------------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR RNIC-KALLDV-L----------------------------------------------- DNAPK_Hsap_DNAPK -ASCLTFLLSL-P----------------------------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 -TWALEVAVLM-K----------------------------------------------- TRRAP_Mmus_TRRAP -ELCLTVPVRL-S----------------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP -ELCITVPVRL-S----------------------------------------------- ATR_Ddis_ATR LDIY-LNILKL-S----------------------------------------------- DNAPK_Ddis_DNAPK -SSCIELLLSL-P----------------------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -ELSLSIPVQI-A----------------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -ELCLTVPVRL-S----------------------------------------------- CC1G_00839_Ccin_ATM -SVCMLLI---------------------------------------------------- CC1G_08126_Ccin_ATR -------PLVL-K----------------------------------------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------FPVRY-CDLPASSQITFTVWDIGGPRTAVPVGGSTFRLFGKKWTLRRGKHRLLL CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -ELCLTVPLRL-T----------------------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K WPGVEADGSVETTTPSKLAIRDEMGRLEKLVKKYERGDLPKNDWLDTMAFRKMEEIHAAE CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------DAEGAMEFFGKCSVAMARGLEKGVASLTVRIEVLEWVGEFPKWFRKLEGMTLLS GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ---------------------S------LLPYLPMLMDP-----------LVSALNG-S- SMG1_Hsap_SMG1 ---------------------K------SETYAPLFSLPSFHKFCKG--LLANTLV-ED- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ---------------------S------LLPYLPMLMDP-----------LVSALNG-S- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ---------------------C------REKIDLLMEQENFRGICRNIAATASKLV---- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ---------------------HDIIELDVRAYVPALQMA-----------FKLGLSH--- ATR_Mmus_ATR ---------------------G------VQKHVGYLLGP-----------FYAALKM-E- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ---------------------S------LLPYLPLLMDP-----------LVCAMNG-S- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ---------------------L------NNPLWPRILRS-----------LLSVQNP-H- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ---------------------F------VLTTMHHFLDN-----------KYGLLDN-D- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ---------------------G------IEVDAEYLLGP-----------LYAALKM-E- DNAPK_Hsap_DNAPK ---------------------HNIIELDVRAYVPALQMA-----------FKLGLSY--- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ---------------------K------SETYAPLFSLPSFHKFSKG--LLANTLV-ED- TRRAP_Mmus_TRRAP ---------------------S------LLPYLPMLMDP-----------LVSALNG-S- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ---------------------V------LAPYLPFLMKP-----------LVFALQQ-Y- ATR_Ddis_ATR ---------------------E------LQFKSIYNLVP-----------LFGDEGI-HD DNAPK_Ddis_DNAPK ---------------------KQLIS--IPLLVPIANLA-----------FQYGISY--- SMG1_Ddis_SMG1 ---------------------------------FKFNKELFRKLIAL--VY-STVV--Q- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ---------------------T------LLPSLHLLVKP-----------LMLALDSSS- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ---------------------S------LLPYLPMLMDP-----------LVSALNG-S- CC1G_00839_Ccin_ATM --------------------------------------------------------E-C- CC1G_08126_Ccin_ATR ---------------------H------LQATLGHAIEP-----------PRTLIKA-T- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K TEKSENLFLYIDLP---------------------------------------------- CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ---------------------H------LLPHLSYLMQP-----------LALALRG-G- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 SSLFVALVAAASDEEHTVRLQA------SKTF---------------------------- GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -----QT-------------------------------------------LVSQGLRTLE SMG1_Hsap_SMG1 -----VN-------------------------------------------ICLQACSSLH FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -----PT-------------------------------------------LISQGLRTLE CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------P-------------------------------------------LESAAC---- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK -----MP-------------------------------------------LAEIGLHALK ATR_Mmus_ATR -----SK-------------------------------------------EIIERIQ--- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -----PN-------------------------------------------IVTQGLRTLE B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM -----RK-------------------------------------------AVSSGFDAL- atl-1_Cele_ATR ---------------------------------------------------------C-- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR -----PT-------------------------------------------MAKGILRLYS ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -----SM-------------------------------------------EIIEEIQ--- DNAPK_Hsap_DNAPK -----TP-------------------------------------------LAEVGLNALE TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 -----VN-------------------------------------------ICLQACSSLH TRRAP_Mmus_TRRAP -----QT-------------------------------------------LVSQGLRTLE smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP -----PD-------------------------------------------LVSQGLRTLE ATR_Ddis_ATR KLYQCFDYVINQSYLIDTDDDDDDTDIDISLEILNTLIDYSNCLNISNIYESISTVT--- DNAPK_Ddis_DNAPK -----LP-------------------------------------------LAHVGLNAIE SMG1_Ddis_SMG1 -----HQ-------------------------------------------ITLSTVFTTL Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -----SE-------------------------------------------LLSTTFRILE ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----QT-------------------------------------------LVSQGLRTLE CC1G_00839_Ccin_ATM -----LK-------------------------------------------IASQDVRLYR CC1G_08126_Ccin_ATR -----QP-------------------------------------------KPSAGST--- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -----FE-------------------------------------------LASQGLRTLE AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ---------------------------------------------------------GAL GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP LCVDNLQPD-F------------------------------------------------- SMG1_Hsap_SMG1 ALSSSLPDD-L------------------------------------------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP LCVDNLQPD-F------------------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 --IQTVLDY-G------------------------------------------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK EW-SVHIDKSI------------------------------------------------- ATR_Mmus_ATR ----CQAQQENLS----------------------------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP LCVDNLQPE-Y------------------------------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM LCIS-------------------------------------------------------- atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR LCISNDFSK-C------------------------------------------------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ----CQTQQENLS----------------------------------------------- DNAPK_Hsap_DNAPK EW-SIYIDRHV------------------------------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ALSSSLPDD-L------------------------------------------------- TRRAP_Mmus_TRRAP LCVDNLQPD-F------------------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP LCIDNLTAE-Y------------------------------------------------- ATR_Ddis_ATR ----NSVKDKNIDNNTENIEKDDGDGGAGGTSENVNNKQIENQKSITEDSKQQQQQQQQQ DNAPK_Ddis_DNAPK YW-NLVVPD-Q------------------------------------------------- SMG1_Ddis_SMG1 VLKGYLNED-Q------------------------------------------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP LIVDNATGD-F------------------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP LCVDNLQPD-F------------------------------------------------- CC1G_00839_Ccin_ATM LHMEDKV----------------------------------------------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP LCIDNLTPD-F------------------------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 LRHKCLSSS-Q------------------------------------------------- GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP --LYDH-IQP---VRAELMQAL-------------------------------------- SMG1_Hsap_SMG1 --LQRC-VDV---CRVQLVHSG-------------------------------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP --LYDH-IQP---VRAALMQAL-------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 --LERL-EK--------------------------------------------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK --LQPY-YKD---ILPCLDGYLNTSTLSDETKSHWGLSALSRAAQKG------------- ATR_Mmus_ATR -GNNDE-VSP---KRRKLSSSLS-----------------------SYKKPSRQPEEIIH ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP --LLEN-MLP---VRGALMQGL-------------------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ---QQF-CKKFVPSI----DKL-------------------------------------- TEL1_Scer_ATM ---ENYSLLF---KRRKCDSDIP-----------------------SILRISD------- MEC1_Scer_ATR --FVDH-F-P---ID--------------------------------------------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -SNSDG-ISP---KRRRLSSSLN-----------------------PSKRAPKQTEEIKH DNAPK_Hsap_DNAPK --MQPY-YKD---ILPCLDGYLKTSALSDETKNNWEVSALSRAAQKG------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 --LQRC-VDV---CRVQLVHSG-------------------------------------- TRRAP_Mmus_TRRAP --LYDH-IQP---VRAELMQAL-------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP --FDPI-IEP---VIDDVSKAL-------------------------------------- ATR_Ddis_ATR PTIEQ------------------------------------------------------- DNAPK_Ddis_DNAPK --VHKH-LDQ---LLPSLNDYLKISTNSSDSTSGGDIDIDSGGSMGGGGVVPPPSSSSRH SMG1_Ddis_SMG1 --IQKL-LNI---TLFKLSDPS-------------------------------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP --LLFT-FRD---NKSEFLQIL-------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --LYEH-IQP---VRAELMQAL-------------------------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ---------Q---ARMNLKDHV-------------------------------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K -------------RFDFPVIFC-------------------------------------- CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --LDPT-LSV---VLRELMEAL-------------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK -----------------------------------------------NADSVPPS----- FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 --LYSV-ASA---AFEQLGDPD-------------------------------------- GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ---------WRTL----R------------------------------------------ SMG1_Hsap_SMG1 ---------TRIR----QAFGKL------LKSIP--LDVVLSNNNHTEIQEI-------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ---------WKTL----R------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ----------------------YPKLLILYRDTALQQLQMLSTNYHAPYFQI-------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK FN----RHVVKHLKRTRN------------------------------------------ ATR_Mmus_ATR VDMDKKSILWNVL----K------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ---------WRVV----S------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ---------WITL----L------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR VDMNQKSILWSAL----K------------------------------------------ DNAPK_Hsap_DNAPK FN----KVVLKHLKKTKN------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ---------TRIR----QAFGKL------LKSIP--LDVVLSNNNHTEIQEI-------- TRRAP_Mmus_TRRAP ---------WRTL----R------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ---------FNLL----Q------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK R--------------KMK------------------------------------------ SMG1_Ddis_SMG1 ---------EQVK----LSYLTL------LSKMVSYFDLNHQKNLNHKVNDI-------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ---------SKHL----------------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ---------WRTL----R------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ---------W-------------------------------------------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ---------EPEP----VASTS-----------------------------AAATTTTTT CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ---------FSHL----K------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ---------PGIQ----AAFRE-----------------------------VLATCALGA GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ---------WRSL----K------------------------------------------ TRRAP_Hsap_TRRAP ------------N----------------------------------------------- SMG1_Hsap_SMG1 ----------SL------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------N----------------------------------------------- CG6535_Dmel_ATM ------------N----------------------------------------------- CG4549_Dmel_SMG1 ----------YA------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------S----------------------------------------------- ATR_Mmus_ATR ------------Q----------------------------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------K----------------------------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------N----------------------------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------Q----------------------------------------------- DNAPK_Hsap_DNAPK ------------L----------------------------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ----------SL------------------------------------------------ TRRAP_Mmus_TRRAP ------------N----------------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------P----------------------------------------------- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------F----------------------------------------------- SMG1_Ddis_SMG1 ----------SL------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -----------RP----------------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------N----------------------------------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K LTTVTQA----------------------------------------------------- CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------P----------------------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 LWVHGWNSDLDA------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------SDPSPVPSAVSQNNTHVTDIIAHITHASKHHSKHLHLMLRDARMDTSQ TRRAP_Hsap_TRRAP ------------------------PADS--ISHVAYRV---------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------Q-DN--AALVAFRV---------------------- CG6535_Dmel_ATM ------------------------Q----------------------------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ----------SPD----------EALSLEEIRIKVVQI---------------------- ATR_Mmus_ATR --------------------------KAESL----------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------APDT-SSMTAAFRI---------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------GESSR--------ATLNSLVIVTASCPFANNNDEGV TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR --------------------------KAESL----------------------------- DNAPK_Hsap_DNAPK ----------SSN----------EAISLEEIRIRVVQM---------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------PADS--ISHVAYRV---------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------QPFNHAISHNVVRI---------------------- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ----------KSNSSLIDPKQLQFKTSIEDLQNRIIRL---------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------APYF--YGPHAIRI---------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------RSDQ--IARVAFRV---------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------APQSHHLAHTTIRI---------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified HALLRQAVNAYCRLMQVLTEFLSNPVG--------------------------------- TRRAP_Hsap_TRRAP -----------------------------------------LGKFGGSNRKMLKESQKL- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -----------------------------------------LGKFGGGNRKMMVEPQAL- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK -----------------------------------------LGSLGGQINKSLVTATS-G ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -----------------------------------------LGKFGGANRKLLNQPQIL- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR KQIIPFLLIPCFQDFRDRVGSKWDNFRFIGLPKSEPSELINLERFTTVL----------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR -----------------------------------------------------------Q ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK -----------------------------------------LGSLGGQINKNLLTVTSSD TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -----------------------------------------LGKFGGSNRKMLKESQKL- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP -----------------------------------------LGKLGGRNRQFLKPPTDL- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -----------------------------------------LGQLGGDNVHFLGKVSLVG SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -----------------------------------------LGKMAGKSRSFSVLSPIL- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----------------------------------------LGKLGGGNRKMLREPQRL- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -----------------------------------------LGKLGGRNRRLLFKEPALI AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------HYVV-TEVQG----------------PSIT------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------SYII-NDKPT----------------ISIV------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK --------ERMKKYVAWDAERR----------------LSFA------------------ ATR_Mmus_ATR ---------------------------------------QI------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------QVAT-LG--D----------------SYINM----------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR WADFSQSEH----FP--FTQL-----------------TNKA------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ---------------------------------------QI------------------- DNAPK_Hsap_DNAPK --------EMMKSYVAWDREKR----------------LSFA------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------HYVV-TEVQG----------------PSIT------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------TE-K-TELDI----------------DA-I------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK --------EEIVNGVAWDTEPK----------------VLIK------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------SIDS-TS-NS----------------RSIPSSNKNNNNNNYYYNGSCS ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------TYED-DENDG----------------PCIT------------------ CC1G_00839_Ccin_ATM ---------------------LEWLKNSWVITGYEKTAGPHPV----------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --------Y----HH--PSEP-----------------AKMV------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified --------------------------------------TSAVLMDELCSELLSVRLLHTI TRRAP_Hsap_TRRAP ------------VEFS----D---CKAS--L----------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -----------AL----------------------------------------------- mei-41_Dmel_ATR -------------TFI----RHFLK-----TQTQHQLLAILQRHLKLSYLCA-------- CG2905_Dmel_TRRAP ------------TYFQ----E---YETP--I----------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -----------AL----------------------------------------------- DNAPK_Mmus_DNAPK ------------VPFR----E---MKPV--IYL--------------------------- ATR_Mmus_ATR -------------SLE----CGTLK-----NSVAE-ALEGITVVLQLTALCTVHCSHQDM ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -------------EFSRMGLD---GNHS--I----------------------------- B0261.2_Cele_FRAP -----------AI----------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM -------------------------------DMDTF------------------------ MEC1_Scer_ATR ------------LSIV----Y---FDL--KRRS--------------------------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -------------SLE----YSGLK-----NPVIE-MLEGIAVVLQLTALCTVHCSHQNM DNAPK_Hsap_DNAPK ------------VPFR----E---MKPV--IFL--------------------------- TOR_Dmel_FRAP -----------AL----------------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------VEFS----D---CKAS--L----------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -----------DL----------------------------------------------- TOR2_Scer_FRAP -----------GL----------------------------------------------- TRA1_Scer_TRRAP ------------ADFK----I---NGMPEDV----------------------------- ATR_Ddis_ATR -------------------------------------QKSIRIYLKALHLIFKICK---- DNAPK_Ddis_DNAPK ------------IPFA----D---QNNI-DIYL--------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -----------GL----------------------------------------------- TRRAP_Ddis_TRRAP NSENYSKVFKLLL----------------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP -----------SL----------------------------------------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------ILFP----D---HKTP--V----------------------------- CC1G_00839_Ccin_ATM -------------NDLILLLA---TICG--I----------------------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP -----------CL----------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ----------PTL----------------------------------------------- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------ISFN----G---NEE--KILL--------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -----------AV----------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -----------SF----------------------------------------------- GK009_Glam_PIKK-Unclassified LSGIQLLYVLHCL----------------------------------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR DGHNVKDHQHKYKKKPPVV----------------------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------LIHLLEENSSHEFEVLGLQLCSFYGTLQDFTKSFAEQLKELL MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR NCRTFKDCQHKSKKKPSVV----------------------------------------- DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------NHHNRVSVKELVN----------------------------------------- DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP PPKD---------------FAHKRQKAMQVDATVFTCISMLARAMGP------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP PPKD---------------FAHKRQKTVQVDATVFTCISMLARAMGP------------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR -------------------------------------VTWMS------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP K----------------------KTTNSDVLDNYFTFLFLFVDAYHE------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM FSK--------------------FEK--------IQCFNWVCFSFIP------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -------------------------------------ITWMS------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP PSKD---------------LT--SKRKVPVDPAVFACITLLAHAVKS------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP QTKF--------------------KFRKKFENEIFYCIGRLAVPLGP------------- TOR2_Scer_FRAP RTKF--------------------KVRKQFEKDLFYCIGKLACALGP------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -------------------------------------L---------------------- DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP MTK--------------------G---KQFCPEVLTCISMLASAVGQ------------- TRRAP_Ddis_TRRAP PC-E---------------TGDDKTKSIPLDKSIQSIKNILLYQL--------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP PHKD---------------IPHRKHKSIIVDPAVFTCISMLARAVGP------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP QNR--------------------GRKNAPSEEPIFQCIGMLAAAVGP------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K PSNS---------------ALLAR------------------------------------ CC1G_13883_Ccin_PI4K --------------------------------------AWLALSRNPALELQVDDNTKST CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP LYFSSVGFYILILYFFVCQLQ--PRRGKP-SMEAIACVGNLTEALGP------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP KSQN---------------FT---KAGSILPPEPLKCIQYITKGAPN------------- GK009_Glam_PIKK-Unclassified --------------------EDK--SSAPIPVNSEECYTQ-------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------------------------------------------------GI------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------------------------------------------------GI------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ----------------------------------------------------QV------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ----------------------------------------------------LLSQKECE MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ----------------------------------------------------EI------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ----------------------------------------------------VL------ TOR2_Scer_FRAP ----------------------------------------------------AF------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------------------------------------------------SM------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ----------------------------------------------------VI------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----------------------------------------------------NL------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K LRAGVAYSMQCFTDLLVQIEAMRVDPSIDIYAWETMAESLKLASVCCIALRELD------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------------------------------------------------LM------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------------------------------------------------LV------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------QLPMEKA----------------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------QQDI-K------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------DFPVDEA----------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------QQDI-K------------------------------------------------ DNAPK_Mmus_DNAPK ------------DVFLPRV----------------------------------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------HLPLSEL----------------------------------------- B0261.2_Cele_FRAP ------TTQI-K------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ----------------ERSTSESTKLRAVNCALQLEKKTGKYINLVAEMSLAVFSKSQTD TEL1_Scer_ATM LSNGDMARLFKVCLPLVKS----------------------------------------- MEC1_Scer_ATR ----------------LPV----------------------------------------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------DVFLPRV----------------------------------------- TOR_Dmel_FRAP ------ADDV-K------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------QLPMEKA----------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------GKLLNR------------------------------------------------ TOR2_Scer_FRAP ------AKHLNK------------------------------------------------ TRA1_Scer_TRRAP ------------PLSVTPG----------------------------------------- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------DVILPNV----------------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------YPHM-Q------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------ARDV-K------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------HLPVSKV----------------------------------------- CC1G_00839_Ccin_ATM ------------SKPIGLV----------------------------------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------TKLL-H------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------EHLH-S------------------------------------------------ CC1G_00331_Ccin_TRRAP ----------------GPI----------------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------EEHV-R------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------QKHV-T------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------ELL-EPM-LAVG mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------ELL-EPM-LAVG DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------AII-PQL-MDIT atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR RIANSFEPLILFLTDNLQLINDFITILIAKLCEKQEFYSELTILKYFKTLQKLFCLAAN- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------DIL-EQM-FYTG SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------NIL-DLM-FKCP TOR2_Scer_FRAP ------------------------------------------------DLL-NLM-LNCP TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------VIL-PQMIVSSG TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------ELL-EPM-LAVG SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------DQL-DLM-LACG CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------RILLLLS-NTSP CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------STL-DIM-FDTG SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------SIL-ECI-FSVG GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP LSPALTAV-----LYDLSRQIPQLKKDIQDGLLKMLSLVLMH------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP LSPALTAV-----LYDLSRQIPQLKKDIQDGLLKMLSLVLMH------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP LSRSLANV-----LKMIMMRIPKLRLNVQDGVMASVYQTLTG------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -----------------------------------------GRNSCKKCGEECFVDPDSK TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP LSPALTVC-----LRELSENVPQLKSAITEGLIGILSQVLMN------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP LSDYMQET-----FQILTERIPSLGPKINDELLNLVCSTLSG------------------ TOR2_Scer_FRAP MSDHMQET-----LMILNEKIPSLESTVNSRILNLLSISLSG------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP LTVVLTDA-----LRDLTINLPTLIPNIQYKLLNLISQVLAN------------------ TRRAP_Ddis_TRRAP -----------------------------------------D------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP LSPALTAA-----LHDLAKQIPQLKKDIQDGLLKMLSLVLMH------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP LSEPLSQA-----LAAIAKYIPPLLKTIQDRLLQLLSMLLSG------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ISDNLVQEAALKSTTVLVRSFPAIAADMTTQLRKFVTS---------------------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP LTPTLEKA-----LNQIVTSLPSFLPPIQERLLDFISLVLCK------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP LCESLTSA-----LQDLSANLHNRLLDIQGLLLYLVANELGG------------------ GK009_Glam_PIKK-Unclassified --------------------------DS-------------------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------IETALD SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------IKSAFR CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------TELALS ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------MRVVAD B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ENVKIDYESLSGLIKGIVARRNTFSQELIREFLQTSRVMLLHVDSKGIASSFTSIIKALD TEL1_Scer_ATM ------------------------------------------------------NESCQL MEC1_Scer_ATR ------------------------------------------------------E----- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------TELALT TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------IETALD smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------IQ---- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------VNLAEK SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------IETALS CC1G_00839_Ccin_ATM ------------------------------------------------------IRTSLP CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------CKLAIT AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -CLK---------SA--NTEPYYRRQAWEVIKCFLVAMMSLED----NKHAL-YQLLAHP SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -------------------K---------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -ALG---------SN--STDQFYRRQSWEVIRCFLAAFISLDD----EKHML-LKLFTHV CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -------------------K---------------------------------------- DNAPK_Mmus_DNAPK -----------------ASDRQTKVAACELLHSMVMFMLGRAT----QMPEG-QGLPPMY ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -QMRYPADMILNPSPAMIPSTHMKKWCMELSKAVLLAGLGSSGSPITPSANL-PKIIKKL B0261.2_Cele_FRAP -------------------S---------------------------------------- atm-1_Cele_ATM -----------------------------------------------------------Q atl-1_Cele_ATR -IGF---------SE--NANAYFR--VWELVCCR-------------------------- TEL1_Scer_ATM SCLL---------LA--NSIKFSKQLLSDEKTINQIYDL--------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK -----------------ASDRQTKVAACELLHSMVMFMLGKAT----QMPEGGQGAPPMY TOR_Dmel_FRAP -------------------K---------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -CLK---------SA--NTEPYYRRQAWEVIRCFLVAMMSLED----NKHAL-YQLLAHP smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -------------------T---------------------------------------- TOR2_Scer_FRAP -------------------E---------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -----------------SPNRQIKVAAGELLHSVLLMMIGNSA----NQSQA-NQ-ISYS SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -------------------K---------------------------------------- TRRAP_Ddis_TRRAP -------------------DSYLQSNAYSLLKYYISLYLSSQDFLINQQSLL-NELLNNL ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP -------------------K---------------------------------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -KLT---------SP--TTDVFYRRQAWEVIRHFIVSMLSLGD----EQRTI-QQLLFHT CC1G_00839_Ccin_ATM -S--CP------------------------------------------------------ CC1G_08126_Ccin_ATR -----------------------RRQVQELVQA--------------------------- CC1G_00894_Ccin_FRAP -------------------Q---------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP T------------LA--KSPPADQMHAYSFLENCASLFLYEG-----------IKGRNVE AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------------------A---------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -------------------I---------------------------------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP N--------------------------------------------------------FTE SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP --------------------------------------------------------PL-- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP D--------------------------------------------------------FVE CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP --------------------------------------------------------PL-- DNAPK_Mmus_DNAPK Q--------------------------------------------------------LYK ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ----------------------------------------------------------LE B0261.2_Cele_FRAP --------------------------------------------------------LI-- atm-1_Cele_ATM ----------------------------------------------------------LE atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK Q--------------------------------------------------------LYK TOR_Dmel_FRAP --------------------------------------------------------AA-- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP N--------------------------------------------------------FTE smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP --------------------------------------------------------PF-- TOR2_Scer_FRAP --------------------------------------------------------KF-- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK R--------------------------------------------------------LYR SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP --------------------------------------------------------PF-- TRRAP_Ddis_TRRAP KQSNNNNNNNSSTVNLNIIELDNENENENDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP --------------------------------------------------------PL-- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP S--------------------------------------------------------FHD CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP --------------------------------------------------------PY-- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP D--------------------------------------------------------FFV AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------------------------------------------------------PY-- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP --------------------------------------------------------NLFL GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP KTIPNVIISHRYKAQDTPARKTFEQALTGAFMSAVIK-----------D-LR-------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ---------------------------------------------------R-------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP NKIMNW-STFQHKAGNETVRETHQTALIGMLVASATK-----------D-LR-------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ---------------------------------------------------R-------- DNAPK_Mmus_DNAPK H---------------------------------TFPVLLQLACDVDQV-TRQ------- ATR_Mmus_ATR ----------------------------LDFYTKVLK-----------S-CRSLLESVQ- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP DFDPNNRTTEVYTCPRESDRELFVNALLAMAYGIWNK-----------DGFR-------- B0261.2_Cele_FRAP ---------------------------------------------------P-------- atm-1_Cele_ATM DDDEAIRASS-------------------------------------------------- atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ---------YELSDILGPILVTNESFMLWGYLQYVGK-----------D-FQSM-NGISS MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ----------------------------LDFYTKVLK-----------S-CRSLLESVQ- DNAPK_Hsap_DNAPK R---------------------------------TFPVLLRLACDVDQV-TRQ------- TOR_Dmel_FRAP ---------------------------------------------------I-------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP KTIPNVIISHRYKAQDTPARKTFEQALTGAFMSAVIK-----------D-LR-------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ---------------------------------------------------I-------- TOR2_Scer_FRAP ---------------------------------------------------I-------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK K---------------------------------IFPSLICLSTDVEQV-TKQ------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ---------------------------------------------------S-------- TRRAP_Ddis_TRRAP NNNNNNIKTFKTKEEYLNEIKNFKDLVYCLFLSITND-----------H-LK-------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ---------------------------------------------------R-------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP GEIPRT-TSHAYKCHDHLSRICFQNALTSMIVSATIK-----------D-LR-------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ---------------------------------------------------R-------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP RTVEGIFDSI------------------------YIPT---IQ--------NEA------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ---------------------------------------------------F-------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP SNAYGVIDGSEDYYLVLTENQSQAVADGHDSGVLDSQ-----------T-SI-------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ----------------------KLELELVIDSM--------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ADRIFEWLKSKWNQLRGTDAKQD--------QFCNFISWLGNKYDPENPFNDKKGEGANP MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ----------------------KLDLEATIDKV--------------------------- DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------P--SAL SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------D--SVC CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ---------------------------------------------------------LYE ATR_Mmus_ATR --------VRICDALMYMQVKSS-----------------------FKDH---------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------H--VYS B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM VSLCWDESHKIWQ---------HFQEQREFLLGVKPEEKSECFNTPFFNL---------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR --------VKIYDALIYMQVNSS-----------------------FEDH---------- DNAPK_Hsap_DNAPK ---------------------------------------------------------LYE TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------P--SAL smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ---------------------------------------------------------LFQ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------EKFDSL ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------P--SSL CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR --------------------------------------------------IISPD--SIT CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -----------------------------------------------ESYLR--K--LAS AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP PFVASLIRHYTMVAVAQQCGPFLLPCYQVGSQPSTAMF---------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP --------H-------------------PGMPKG-------------------LAH---- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP PVMAAVVRHYTMVAIAQQAGPFPQ-------------K---------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP --------H-------------------PGMPKG-------------------LAH---- DNAPK_Mmus_DNAPK PLVMQLIHWLTN------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP KFFIKVLRQFALIGVLEYIGGNGW------------MR---------------------- B0261.2_Cele_FRAP --------P-------------------KSEP---------------------IGR---- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK PLVMQLIHWFTN------------------------------------------------ TOR_Dmel_FRAP --------L-------------------PYTAL--------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP PFVASLIRHYTMVAVAQQCGPFLLPCYQVGSQPSTAMF---------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP --------Q-------------------PGSPME-------------------IPSFSRE TOR2_Scer_FRAP --------Q-------------------SNQYDF-------------------NNQFSIE TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK PLVFQMIHWFTR------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP --------E-------------------PGAPSP-------------------YRK---- TRRAP_Ddis_TRRAP KFLNNFIYH-------------------FVLYLSTF------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP --------H-------------------PGTPRA-------------------LLS---- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP PFMMNVVRHITLVAVAQQAGPLPT-------------A---------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR WMDDDFRPN--------------------------------------------------- CC1G_00894_Ccin_FRAP --------P-------------------LGAPAP-------------------LGR---- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP TVFENEIRRNQS------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------S-------------------QRKSLL-------------------V------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP --------I-------------------PGTRPSTTQATTHVEDTRTNEDAIELAH---- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -------------------------------------------------HSE-ENGS--- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ---QLASPGL-------------------------------------------TTLP--- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -------------------------------------------------G---YQAT--- CG6535_Dmel_ATM ----LI------------------------------------------S-ETTTNSE--- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ---QLASPGL-------------------------------------------TTLP--- DNAPK_Mmus_DNAPK -------------------------------------------------NK-KFESQ--- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -------------------------------------------------HAE-EEGV--- B0261.2_Cele_FRAP ---PASPKAI--------------------------------------LQK---AET--- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK -------------------------------------------------NK-KFESQ--- TOR_Dmel_FRAP ---PT--IAI--------------------------------------DGS--L--M--- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -------------------------------------------------HSE-ENGS--- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP RAREWRNKNI--------------------------------------LQKTGESND--- TOR2_Scer_FRAP KARKSRNQSF--------------------------------------MKKTGESND--- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -------------------------------------------------NK-KQESD--- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP SATPFQGGSI--------------------------------------P---QLGQN--- TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ---PTGQTGT------------------------------------------ALSSI--- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------------------------------------------HSRQKSLN--- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP NEFPAPPNQL--------------------------------------TAT--QMTT--- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -------------------------------------------------RE-VGARP--- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -RLPQ--KA---------------------------------------VG---LPSS--- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ---DLSITGLKEESEQCDFKNSLSVYQTVTTSAGITALYKLSDRIATALGTSKLRPR--- GK009_Glam_PIKK-Unclassified --------------------------------------------------------SSIS TRRAP_Hsap_TRRAP --------------------------------------K--GMD---------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP --------------------------------------E--ASD---------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP --------------------------------------H--GID---------------- CG6535_Dmel_ATM --------------------------------------E--IKEKQLVLQMLIRHNKL-- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP --------------------------------------E--ASD---------------- DNAPK_Mmus_DNAPK --------------------------------------DT-VAL---------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM --------------------------------------------NFGLLEAIIQGSLVEL C47D12.1_Cele_TRRAP --------------------------------------LPLCLD---------------- B0261.2_Cele_FRAP --------------------------------------D--PKE---------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM --------------------------------------------NFGLLGAIIQGSLVEV ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK --------------------------------------DT-VAL---------------- TOR_Dmel_FRAP --------------------------------------Q--NGD---------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP --------------------------------------K--GMD---------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP --------------------------------------D--NND---------------- TOR2_Scer_FRAP --------------------------------------D--ITD---------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK --------------------------------------DT-MNL---------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP --------------------------------------S--DVD---------------- TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM --------------------------------------------GFDLLTSLVHHGIVKP ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP --------------------------------------D--SGD---------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --------------------------------------D--NMD---------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP --------------------------------------T--DKN---------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --------------------------------------TP-SPV---------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------------------------------------E--IQG---------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP --------------------------------------R--HST---------------- GK009_Glam_PIKK-Unclassified ETYTMVPLATQLLLLLFRRHLHLSNMVGLQQHESSMTSKL-FAS---------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------NQKLSSTLLNNIISNEMLKRNECLATIREIFIHADKCGQDKA------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM DREFWKLFTGSACK----------------PSSPSVCCLTLALSICVVPD--AIKMGTEQ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM DREFWKLFTGSACR----------------PSCPAVCCLTLALTTSIVPG--TVKMGIEQ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM DKEVWKLFLPDVTQ----------------PSRCSVTFLLTLLTSHPIPENHVCQVGLLA ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ---------SADLEPIIAWAYGSADRFIAAQMIHN------------------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM SVCEANR-SFSVKESIMRWLL-----------FYQLEDDLEDSTELPPILQRNFPHLVVE C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM NMCEVNR-SFSLKESIMKWLL-----------FYQLEGDLENSTEVPPILHSNFPHLVLE ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM SLTGVQRGQYPLRHQLLNWIL-----------PAEEVEDAGERLAVTPLILKSVPRDLLA ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ----------IDSIDAQLQADTFAISIINFLDVQQLRQISQSEHIVPST--ERNLLAYKY CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM KILVSLTMKNSKAAMK--FFQSVPECEQHCEDKEEPSFSEVEELFLQTTFDKMDFLTTVK C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM KILVSLTMKNCKAAMN--FFQSVPECEHHQKDKEELSFSEVEELFLQTTFDKMDFLTIVR ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM SLLTTLFTKNCRGQQLGIAFAARPNPE-----NGSSRLSFIEELYLRASF--HIPL--TK ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -----------------------------------------------------------P SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -----------------------------------------------------------V mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -----------------------------------------------------------P CG6535_Dmel_ATM NEQL-------------------------------------------------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -----------------------------------------------------------V DNAPK_Mmus_DNAPK -----------------------------------------------------------L ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM EYAVE--KFQSSVGFS--------VQQNLKESLDHYLLGLSEQLLSNYSSE-ITSSETLV C47D12.1_Cele_TRRAP -----------------------------------------------------------S B0261.2_Cele_FRAP -----------------------------------------------------------L atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ECGIE--KHQSSIGFS--------VHQNLKESLDRCLLGLSEQLLNNYSSE-ITNSETLV ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK -----------------------------------------------------------L TOR_Dmel_FRAP -----------------------------------------------------------G SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -----------------------------------------------------------P smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -----------------------------------------------------------I TOR2_Scer_FRAP -----------------------------------------------------------A TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -----------------------------------------------------------L SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -----------------------------------------------------------P TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM DSQVNAVEHDTARAFSTEGAVIMMVVQSVSERLGH-------------VVKLVTD----S ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP -----------------------------------------------------------L SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----------------------------------------------------------P CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP -----------------------------------------------------------S CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -----------------------------------------------------------L AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -----------------------------------------------------------P SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -----------------------------------------------------------S GK009_Glam_PIKK-Unclassified -----------------------------------------------------------C TRRAP_Hsap_TRRAP LVL--------------------------------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP GSITLALRTLGSFEFEGHSLTQFVRHCADH------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP MIL--------------------------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ASITLALRTLGSFEFEGHSLTQFVRHCADH------------------------------ DNAPK_Mmus_DNAPK EAI--------------------------------------------------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM RCSSLLVGVLGCYCYMGI------------------------------------------ C47D12.1_Cele_TRRAP SVM--------------------------------------------------------- B0261.2_Cele_FRAP QRIVLAVDVLGEFYFSRGALQRIMQYVADY------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM RCSRLLVGVLGCYCYMGV------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK EAI--------------------------------------------------------- TOR_Dmel_FRAP ATTVLALKTLGTFNFEEQNMLDFVQRCADY------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP LVL--------------------------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP KIIIQAFRMLKNIK-SRFSLVEFVRIVALS------------------------------ TOR2_Scer_FRAP QILIQCFKMLQLIH-HQYSLTEFVRLITIS------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK NAI--------------------------------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP QMIALALKTLGSFDFSKHNLLEFVRECVVN------------------------------ TRRAP_Ddis_TRRAP -----------------------KFNYSII------------------------------ ATMa_Spur_ATM QC---------------------------------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP TSTVLALRTLGNFDFEGHSLTQFVRHCADH------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP HVL--------------------------------------------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ELITLALKTLGTFDFSGHVLNEFVRSCALP------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K --------PLPLFEFEF------------------------------------------- CC1G_00331_Ccin_TRRAP NSF--------------------------------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ALVQLALKILTNFNFKGHDLLEFAREAVVM------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP EAILLAFQALYDFDFSLFDLTIFAADYLTR------------------------------ GK009_Glam_PIKK-Unclassified FAFLFSLDTIFSASHDGYMVI--------DFSEEHKDLLRSFLPATATEEFLISLLPFAI TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------------------FL----------------------------------NS mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------------------FL----------------------------------NS DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM -----------------------ITEDEAHKSELFQKAKSLMQCAGESISL-----FKNK C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ----------------------YL----------------------------------TA atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----------------------IAEEEAYKSELFQKAKSLMQCAGESITL-----FKNK ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ----------------------FI----------------------------------VH SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ----------------------YI----------------------------------EH TOR2_Scer_FRAP ----------------------YI----------------------------------EH TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------------------YL----------------------------------DD TRRAP_Ddis_TRRAP ----------------------SM----------------------------------KE ATMa_Spur_ATM -------------------------------KEVL---LKRFALGFK---VLEIQSDLTP ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ----------------------FL----------------------------------SS SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----------------------YL----------------------------------ED CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -----------------------A----------------------------------SE CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------------------HL----------------------------------ED SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------------------YL----------------------------------RN GK009_Glam_PIKK-Unclassified ASFIPGASVPSDFVSLYLKQISQL----------------------------------YD TRRAP_Hsap_TRRAP -------------IDA-----------------------------------------IAI SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP EHKEIRM------EAA-----------------------------------------RTC mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -------------IDA-----------------------------------------LAS CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP EHKEIRM------EAA-----------------------------------------RTC DNAPK_Mmus_DNAPK -------------LDG-----------------------------------------IVD ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM TNEESRI------GSL-----------------------------------------RNV C47D12.1_Cele_TRRAP -------------VDA-----------------------------------------LII B0261.2_Cele_FRAP DNVEIRL------AAV-----------------------------------------SSC atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM TNEEFRI------GSL-----------------------------------------RNM ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK -------------LDG-----------------------------------------IVD TOR_Dmel_FRAP EQQEIRL------EAV-----------------------------------------QTC SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -------------IDA-----------------------------------------IAI smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP TDPRVRK------LAA-----------------------------------------LTS TOR2_Scer_FRAP EDSSVRK------LAA-----------------------------------------LTS TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -------------VDA-----------------------------------------VGN SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP DNIEIRR------EAA-----------------------------------------ITC TRRAP_Ddis_TRRAP LDPKIF-------LEA-----------------------------------------LVD ATMa_Spur_ATM DSSISRA------HSL-----------------------------------------KSL ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP EHKEIRI------EA--------------------------------------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------IDA-----------------------------------------ISA CC1G_00839_Ccin_ATM ---------------I-----------------------------------------VTA CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP DNPQVRC------AAA-----------------------------------------ETC CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K TRAPPPL------AAA-----------------------------------------AKC CC1G_00331_Ccin_TRRAP -------------LEA-----------------------------------------IPH AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP DDAGVRR------HAA-----------------------------------------RCC SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP DSSTLRI------KAA-----------------------------------------QTI GK009_Glam_PIKK-Unclassified TNPRVQSYYKLICRIADSCHTVATLNQSAQTSRYMLAYIFFQYFLVQVCGEKYHLITTTI TRRAP_Hsap_TRRAP CMAYEE-----KE----------------------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP SRLLTP-----SIHLIS------------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP CMGHEE-----KE----------------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP SRLLTP-----SIHLIS------------------------------------------- DNAPK_Mmus_DNAPK PVDSTLRDFCGRC----------------------------------------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM MHLCTS-----CLCIHTK------------------------------------------ C47D12.1_Cele_TRRAP CLSETSSS---------------------------------------------------- B0261.2_Cele_FRAP CEMVVP-----FVGVYK------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ---SEA-----TV----------------------------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM MQLCTR-----CLSNCTK------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK PVDSTLRDFCGRC----------------------------------------------- TOR_Dmel_FRAP TRLLKL-----AVQ--S------------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP CMAYEE-----KE----------------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP CEIYVK-----DN----------------------------------------------- TOR2_Scer_FRAP CDLFIK-----DD----------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK PLDGARRDFAGQC----------------------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP AQLMVG-----TEE---------------------------------------------- TRRAP_Ddis_TRRAP VMSMSS-----HN----------------------------------------------- ATMa_Spur_ATM CSVLLP-----LY---AC------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP CMAHEE-----KE----------------------------------------------- CC1G_00839_Ccin_ATM MQKESQLQ---------------------------------------------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP CTLFIK----------D------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K LALC-------------------------------------------------------- CC1G_00331_Ccin_TRRAP GLAREQ-----PA----------------------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP CRLVEH-----SYQ--T------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP LKLMSE-----DHFEKIRRGKHSQYKSMTIKAEDCHSWAGSTLGEAPTPSGGATIIPPAV GK009_Glam_PIKK-Unclassified SELCM------EQIC--------------------------------------------- TRRAP_Hsap_TRRAP -------------------L---------------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------GH---------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -------------------L---------------------------------------- CG6535_Dmel_ATM ----------------------------------ICFDKDYATPFEIAIKKSYTSNLTAK CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------GH---------------------------------------- DNAPK_Mmus_DNAPK -------------------V---------------------------------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM -------------------HTPNKIASGF-FLRLL------------------------- C47D12.1_Cele_TRRAP -------------------F---------------------------------------- B0261.2_Cele_FRAP ------------------KV---------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -------------------E---------------------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -------------------KSPNKIASGF-FLRLL------------------------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK -------------------I---------------------------------------- TOR_Dmel_FRAP ------------------SE---------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -------------------L---------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -------------------I---------------------------------------- TOR2_Scer_FRAP -------------------I---------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -------------------L---------------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -------------------I---------------------------------------- ATMa_Spur_ATM -------------------QPGQQGEAGQMVASLV------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------------L---------------------------------------- CC1G_00839_Ccin_ATM -------------------S---------------------------------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------PI---------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -------IKLAPGDDLIMS----------------------------------------- CC1G_00331_Ccin_TRRAP -------------------Q---------------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------AI---------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP VSNQSFATTISPKTR---HI---------------------------------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM IVRCVGLIAQRCPDI----YLLENFAVICKSTAKFITMPT-------------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM -------------TS----KLMNDIADICKSLASCTKKPLDHG--------------V-H C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -------------TS----KLMNDIADICKSLASFIKKPFDRG--------------EVE ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM -------------RSCTPAELLDALLDVLHKRGSCQ----KQGSKVTNHHDPFGDSMELG ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM PGEDDEDGGGCDSLMEAEGPSSTGLSTAYPASSVSDANDYGENQNAVGAMSPLAADYLSK C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM SMEDDTNG----NLMEVEDQSSMNLFNDYPDSSVSDANEPGESQSTIGAINPLAEEYLSK ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM SDDEFPSTQQAQGDLDDDFGEVTTISAQATTGTSEKKRHKSREDSMTGTHSMLSIESLPH ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM -----------------------------LEVRFATLFTFTILLE-SNCVTSDAIGHSR- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM QDHLLLDMLRFLG-RSVTASQSHTVSFRGADI----RRKLLLLLD-SSILD-----LMKP C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM QDLLFLDMLKFLC-LCVTTAQTNTVSFRAADI----RRKLLMLID-SSTLE-----PTKS ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM EEQLAISSAKVLSSWCWSCDFSDQVTSEARDNRTAVTQRLLKMFDDG------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ----------------------------------------------CKIGEVALAVIFDV SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------------------------------------------A------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ----------------------------------------------CKPGIACMGIILDT CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------------------------------------------A------------- DNAPK_Mmus_DNAPK ----------------------------------------------QEFLKWSI------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM LHLHMYLVLLKDLPGNEHSLPMEDVVE-LLQPLSLVCSLHRRDQDVC------------- C47D12.1_Cele_TRRAP ----------------------------------------------IIAGVMSLRHINET B0261.2_Cele_FRAP ----------------------------------------------T------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ----------------------------------------------KKLQMYIPLIGRSF TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR --------------------------------------------------------ALKY ATM_Hsap_ATM LHLHMYLMLLKELPGEEYPLPMEDVLE-LLKPLSNVCSLYRRDQDVC------------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ----------------------------------------------REFLKWSI------ TOR_Dmel_FRAP ----------------------------------------------S------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ----------------------------------------------CKIGEVALAVIFDV smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ----------------------------------------------C------------- TOR2_Scer_FRAP ----------------------------------------------C------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ----------------------------------------------CEFAKWSL------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------------------------------------------P------------- TRRAP_Ddis_TRRAP ----------------------------------------------I------------- ATMa_Spur_ATM ---------------EDQDLTNSYEVQLTNGPRRELVSVNRKVQEVC------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----------------------------------------------CKTGQLAMTVIVET CC1G_00839_Ccin_ATM ----------------------------------------------IRNFMLYAQLPSYK CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----------------------------------------------C------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ----------------------------------------------CERAKEVVAILIND AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------------------------------------------T------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------------------------------------------R------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP AS---------------------------------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ---HVVS----------------------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP AT---------------------------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ---HVVS----------------------------------------------------- DNAPK_Mmus_DNAPK --KQ-------------------------------------------------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ---KTIL----------------------------------------------------- C47D12.1_Cele_TRRAP LS---------------------------------------------------------- B0261.2_Cele_FRAP ---SDKR----------------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR AL---------------------------------------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ---KTIL----------------------------------------------------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK --KQ-------------------------------------------------------- TOR_Dmel_FRAP ---MENS----------------------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP AS---------------------------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ---KQTS----------------------------------------------------- TOR2_Scer_FRAP ---KQTS----------------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK --KN-------------------------------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ---TPTR----------------------------------------------------- TRRAP_Ddis_TRRAP ---NQSNIEDLQTISTSKFNKAHITSLLDMIFNCSNQIFSENSNSKKNNELMTSSTDVKD ATMa_Spur_ATM ---AEAM----------------------------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP AA---------------------------------------------------------- CC1G_00839_Ccin_ATM PS---------------------------------------------------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ---YQAS----------------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP LIEM-------------------------------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ---GRSA----------------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ---THSS----------------------------------------------------- GK009_Glam_PIKK-Unclassified ---KQTS----------------------------------------------------- TRRAP_Hsap_TRRAP ---------------------------------IILGSKERACQLPLFSY---------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ---------------------------------NIMGNKDRACKLPIIQY---------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ---------------------------------TTP--QQQEKSPVNSKS---------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ---------------------------------LTLPDIDQMSKVPMCKY---------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ---------------------------------LGDDAALKVHGFLSNVL---------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ---------------------------------ITP--QQQEKSPVNTKS---------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ---------------------------------IILGSKERACQLPLFSY---------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ---------------------------------TSV--KQQEKNAFNFKS---------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP GEKVEMETEDSLKKDEMSAAATSEIKKETNVVVENEQDKDTVLISPIFKY---------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ---------------------------------AVMGSKARACSLSIFEY---------- CC1G_00839_Ccin_ATM ---------------------------------EQSKSVSFPTSVEPGVE---------- CC1G_08126_Ccin_ATR -----------------------------------------------EPYTLRRILADVA CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ---------------------------------RTRPNIGLQGIFPLLHS---------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ---IVERLCACCYEQAWYAKLGGVVSI-KFLMERLPL----------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ---LAEKMVSLCYDRPWYSKVGGCQAI-QFLCKHMSL----------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ---LFKRLYSLALHPNAFKRLGAALAF-NHIYKEFREE---------------------- ATR_Mmus_ATR ---VLEELCGML-------------------------SLPWIYSYSDDNSLKMTTFATNL ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ---LMEKVFKLCHGPAWYARSGGINAI-GYMIESFPR----------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ---SARLSSTVKATLFASSFAHSVLKN-CEIDWNVSY----------------------- TEL1_Scer_ATM ---PKVSLDLTR------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ---ILEDLCGML-------------------------SLPWIYSHSDDGCLKLTTFAANL DNAPK_Hsap_DNAPK ---LFKRLYSLALHPNAFKRLGASLAF-NNIYREFREE---------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ---IVERLCACCYEQAWYAKLGGVVSI-KFLMERLPL----------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ---ILKRIYSLAHHPDPYKRLGAAISF-NQLYRIFREE---------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ---LVKLFIKCCYDKDFSVKGAGLIGI-EYIIENVKL----------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ---VADRMCNCCYERAWYAKLGGCIAI-KFMMENMDM----------------------- CC1G_00839_Ccin_ATM ---PADISPLSSSRRSPNAREGRVLSFLERMIKALKL----------------------- CC1G_08126_Ccin_ATR ERFSRPL----SQADDESRIKLARNLA-KLPCLLVVCT---------------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K -------------------------------RKTVTG----------------------- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ---LANRFTGLCLDESWIRKAAGCNGI-KLMLNAPVVA---------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -----------------------------------------TWVLQNQQTFLKAL----- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -------------------------------------IRLETPSSVHTQMQSFYAQQYMR CG2905_Dmel_TRRAP -----------------------------------------RALFQNLFNFLKAF----- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ----------------------------------------GSLVEQFVFEALVTY----- ATR_Mmus_ATR LPLSQRVWDSYSPQAQSKCVFLLTLFPRRIFLEWRTAVYNWALKSSHEVIRASCVKGFFI ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -----------------------------------------KFVMDFVIDVVDSI----- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -----------------------------------------TWKTQFSQCLIKAP----- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR LTLSCRISDSYSPQAQSRCVFLLTLFPRRIFLEWRTAVYNWALQSSHEVIRASCVSGFFI DNAPK_Hsap_DNAPK ----------------------------------------ESLVEQFVFEALVIY----- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -----------------------------------------TWVLQNQQTFLKAL----- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ----------------------------------------DSLVDQFIFEILHNI----- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -----------------------------------------SWIQPFQHLILKSL----- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----------------------------------------CWVQSHLYLFLKAL----- CC1G_00839_Ccin_ATM -----------------------------------------HWQS--------------- CC1G_08126_Ccin_ATR ----------------------------------------GESCTTFRNASGPSLLGFYV CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K -----------------------------------------AQTVPTLPL---------- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ----------------------------------------QKWVSDREIELVRNL----- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ---LFVM-MDLTG----------------EVSN--------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP --------------------------------Q--------------------------- mei-41_Dmel_ATR LFQSEETQEIFC------------------------------------------------ CG2905_Dmel_TRRAP ---MFVL-MDLEG----------------DVSN--------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP --------------------------------Q--------------------------- DNAPK_Mmus_DNAPK ---MESLALAHED----------------EKSLG-------------------------- ATR_Mmus_ATR LLHQ----QNSC------------------------------------------------ ATM_Mmus_ATM ----S------------------------------------------------------- C47D12.1_Cele_TRRAP ---MEVI-LGTVE----------------EISS--------------------------- B0261.2_Cele_FRAP --------------------------------N--------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ---VGTC-E--------------------------------------------------- TEL1_Scer_ATM -----------YN----------------EILYR-------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ----N------------------------------------------------------- ATR_Hsap_ATR LLQQ----QNSC------------------------------------------------ DNAPK_Hsap_DNAPK ---MESLALAHAD----------------EKSLG-------------------------- TOR_Dmel_FRAP --------------------------------K--------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ---LFVM-MDLTG----------------EVSN--------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP --------------------------------L--------------------------- TOR2_Scer_FRAP --------------------------------V--------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ---FFSLRIGDDL----------------TNTSS-------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP --------------------------------G--------------------------- TRRAP_Ddis_TRRAP ---LFVC-EDLSY----------------SGYQ--------------------------- ATMa_Spur_ATM ----A------------------------------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ---LFVM-MDLTK----------------EVSS--------------------------- CC1G_00839_Ccin_ATM ------------------------------TPN--------------------------- CC1G_08126_Ccin_ATR PILQALL-AGPAD----------------EVTP--------------------------- CC1G_00894_Ccin_FRAP --------------------------------S--------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K -----HL-RSLRKPRLSDDPLGQLETDSFNTP---------------------------- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ---MHAL-KDLPY----------------DLPR--------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------------------------------SRLT------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP --------------------------------SHLDDMSSTSFCINQDCILSQDILKSSD GK009_Glam_PIKK-Unclassified --------------------------------V--------------------------- TRRAP_Hsap_TRRAP ------------------------GAV----------------------------AMAKT SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -----------T-----------A--V----------------------------QVVAD mei-41_Dmel_ATR --------------------------------------------------S--------- CG2905_Dmel_TRRAP ------------------------GAI----------------------------EITKS CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -----------T-----------A--V----------------------------QVVAD DNAPK_Mmus_DNAPK -----------------------TV-----------------------------QQ---- ATR_Mmus_ATR --------------------------------------------------N--------- ATM_Mmus_ATM -----------NVLHIVTNLGQGS------------------------------------ C47D12.1_Cele_TRRAP ------------------------GSA----------------------------DSAYD B0261.2_Cele_FRAP -----------S-----------L--L----------------------------QTIYG atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM -----------------------LLENIESDAFSSPLQKFTWVAKLIQIVD--------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----------HVLHVVKNLGQSN------------------------------------ ATR_Hsap_ATR --------------------------------------------------N--------- DNAPK_Hsap_DNAPK -----------------------TI-----------------------------QQ---- TOR_Dmel_FRAP -----------T-----------L--S----------------------------DTVSH SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------GAV----------------------------AMAKT smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -----------H-----------S--L----------------------------NTVSE TOR2_Scer_FRAP -----------H-----------A--L----------------------------HSVSE TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -----------------------SKNNSNSNSNNNNNNNNNSEDGTEDSIVEIASK---- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -----------H-----------S--A----------------------------VIVGE TRRAP_Ddis_TRRAP -----------P-----------T--I----------------------------DYASE ATMa_Spur_ATM -----------FLRAITPHLAMSG------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------GAL----------------------------NMAKS CC1G_00839_Ccin_ATM ------------------------PTI----------------------------EVARR CC1G_08126_Ccin_ATR -----------------------SVRR----------------------------EVYSV CC1G_00894_Ccin_FRAP -----------H-----------A--I----------------------------EVISD CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K --------NMYS-----------L--L----------------------------NY--- CC1G_00331_Ccin_TRRAP ------------------------DVE----------------------------DVIET AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ---SGRPLTFRK-----------H--R----------------------------ILIEE SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP LGTDGFFNSGPY-----------R--H----------------------------MLISD GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP TLEQLLMRCA-------------------------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP VLSKL------------------------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP YMKSMLEICL-------------------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP VLSKL------------------------------------------------------- DNAPK_Mmus_DNAPK --------C--------------------------------------------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP CLKKMMRVYF-------------------------------------------------- B0261.2_Cele_FRAP VLRAV------------------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK --------C--------------------------------------------------- TOR_Dmel_FRAP VIERL------------------------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP TLEQLLMRCA-------------------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP VLSKL------------------------------------------------------- TOR2_Scer_FRAP VLSKL------------------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK --------Y--------------------------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP VLEKL------------------------------------------------------- TRRAP_Ddis_TRRAP IIINLIKLCVPNLNIVPDSMEIDQSTTTASTTETAATTTTTETATPMVTESTAIVTEPTA ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP NVDLVLKLCA-------------------------------------------------- CC1G_00839_Ccin_ATM TLD--------------------------------------------------------- CC1G_08126_Ccin_ATR LL-PVLK----------------------------------------------------- CC1G_00894_Ccin_FRAP VLDKL------------------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ----------------------------------------------------------SH CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP LL-DVLRLS--------------------------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ILEKL------------------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP TLRQI------------------------------------------------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP TTPTATPTSTPTSTSTPTPTPIPTATTSSTTTAPTTTTTTTTNLSSSSTINQKPHCKLNQ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K SSPSL------------------------------------------------------- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -----------------T--------------------------------PLKD-EE--- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ---------------LVV------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -----------------T--------------------------------PINE-CY--- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ---------------LVV------------------------------------------ DNAPK_Mmus_DNAPK --------------------------------------------------------CDAI ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ---------------------------------------------------IKE-E---- B0261.2_Cele_FRAP ---------------CSV------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -----------------EALQIMFKRYSTIFTRCFLNRLFFDASSAGAQKPSY-DEH--- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK --------------------------------------------------------CDAI TOR_Dmel_FRAP ---------------LMV------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -----------------T--------------------------------PLKD-EE--- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ---------------LAI------------------------------------------ TOR2_Scer_FRAP ---------------LMI------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK --------------------------------------------------------SNVL SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ---------------LVV------------------------------------------ TRRAP_Ddis_TRRAP LKLKDRELLKLILEILME------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----------------T--------------------------------PPTGADA--- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ---------------LTV------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --------------------------------------------------------NS-- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ---------------LVA------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ---------------III------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------RAEE-- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------KNID-- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK DHLRRIIEKKHVSLNKAKKRRLPQGFPPLT------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -----------------------------------------------------GQEEENL B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------RIRE-- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK DHLCRIIEKKHVSLNKAKKRRLPRGFPPSA------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------RAEE-- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK AALTKVIIK--------------------RADMLN--------------KPSNTRR---- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------ENPK-- CC1G_00839_Ccin_ATM ----------------------------------------------------------FA CC1G_08126_Ccin_ATR --------------------------------------------------HRNEEEPD-- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --------------------------------------------------SLDFTGDG-- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK -----------------------------REMARTSFKFACFCDDLLNTADD-------- FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -IVAAQEKSFHHVTHDLVREVTSP------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -------------------GITDP------------------------------------ mei-41_Dmel_ATR -----------NLPQLYISGFIK------------------------------------- CG2905_Dmel_TRRAP -LKDLQAKATYEVIHELVRHITSP------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -------------------GITDP------------------------------------ DNAPK_Mmus_DNAPK -----SLCLLDLVEWLLA-HCGRP------------------------------------ ATR_Mmus_ATR -----------QIPKMLVDRVKDD------------------------------------ ATM_Mmus_ATM -----------------------VD----MESTRIAQGHFLTVMGAFWHLTKEKKCVFSV C47D12.1_Cele_TRRAP TLATI-------FVSAISKHYFHS------------------------------------ B0261.2_Cele_FRAP -------------------IVNDQ------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -I---------------------------------------------------------- TEL1_Scer_ATM -----------NLCGDSTFSEFIA------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----------------------MD----SENTRDAQGQFLTVIGAFWHLTKERKYIFSV ATR_Hsap_ATR -----------RVPKILIDKVKDD------------------------------------ DNAPK_Hsap_DNAPK -----SLCLLDLVKWLLA-HCGRP------------------------------------ TOR_Dmel_FRAP -------------------AITDM------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -IVLAQEKSFHHVTHDLVREVTSP------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -------------------TIADP------------------------------------ TOR2_Scer_FRAP -------------------AITDP------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ---E-HKDLSQFVQWVFQNGCSRT------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -------------------GIADP------------------------------------ TRRAP_Ddis_TRRAP -------------------RITSW------------------------------------ ATMa_Spur_ATM -----------------------SDDGMVSSDIKVCRDVALLLLAAFWQLQATY--STPV ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -LAVAQQKAFHDVTRELVREVTSP------------------------------------ CC1G_00839_Ccin_ATM VIAI-------------------------------------------------------- CC1G_08126_Ccin_ATR -E---------PVLEMITRGVTDD------------------------------------ CC1G_00894_Ccin_FRAP -------------------GIADP------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -AAH-ARNKIVHLAGMFFPEFQSS------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------------------AVSDT------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -------------------GTTDI------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ----------------------------------------NSTVR-------------KQ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------------------------------------DPDIR-------------YC mei-41_Dmel_ATR --------------------------------------------PEQLMKALPTINNRSG CG2905_Dmel_TRRAP ----------------------------------------NTIVR-------------EE CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------------------------------------DPDIR-------------YC DNAPK_Mmus_DNAPK ----------------------------------------QTECR-------------HK ATR_Mmus_ATR ----------------------------------------SDMVK-------------KE ATM_Mmus_ATM RMALVKCLQTLLEADPYSEWAILNVKGQD---------FPV------------------- C47D12.1_Cele_TRRAP ----------------------------------------NERVR-------------EF B0261.2_Cele_FRAP ----------------------------------------DVRVR-------------MQ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ----------------------------------------AYKRTTLITIPQLSFDSQNS MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM RMALVNCLKTLLEADPYSKWAILNVMGKD---------FPV------------------- ATR_Hsap_ATR ----------------------------------------SDIVK-------------KE DNAPK_Hsap_DNAPK ----------------------------------------QTECR-------------HK TOR_Dmel_FRAP ----------------------------------------DCNVR-------------IR SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ----------------------------------------NSTVR-------------KQ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ----------------------------------------LQDIR-------------LE TOR2_Scer_FRAP ----------------------------------------VAEIR-------------LE TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ----------------------------------------ESIVR-------------YE SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------------------------------------DPSIR-------------KT TRRAP_Ddis_TRRAP ----------------------------------------SGHTR-------------SL ATMa_Spur_ATM KHQMALCIEALIKIDPDSQWTFIKAKGREKGHGDSNERSEV------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----------------------------------------NQTVR-------------EQ CC1G_00839_Ccin_ATM --------------------------------------------V-------------FQ CC1G_08126_Ccin_ATR ----------------------------------------DRAVR-------------VQ CC1G_00894_Ccin_FRAP ----------------------------------------DPGIR-------------NV CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ----------------------------------------NRIIR-------------DA AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------------------------------------DASVR-------------ED SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------------------------------------DPEVR-------------MS GK009_Glam_PIKK-Unclassified -----------------------------------------------------------A TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified FCLFSSAYLPSLIINLYLPLSRTALSKELALLCVESRTPVMMSYPRLSVEDFVTVTGALA TRRAP_Hsap_TRRAP AMHSL-Q----------------------------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP VLASL-D----------------------------------------------------- mei-41_Dmel_ATR RAQVIRLLLCSQPGKLSVFKVK-----------DRIELYCPKCRP--------------- CG2905_Dmel_TRRAP SMVLL-K----------------------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP VLASL-D----------------------------------------------------- DNAPK_Mmus_DNAPK SMELF-YKFVPLLPGN------KSPSLWLKDLI--KKKGISFLINTFE--G---GASSSD ATR_Mmus_ATR FASVLGQLVCTLHGMFYLSS-SV----EPCFE--HMDLFSKNLKATSQHECSSSQ----- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP AIGLM-D----------------------------------------------------- B0261.2_Cele_FRAP VISCF-G----------------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM YQSFFEEVLSIRTINVDHLVLDK----INMKEI--VNDFIRMQKNK--SQTGTSA----- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR FASILGQLVCTLHGMFYLTSSLT----EPFSEHGHVDLFCRNLKATSQHECSSSQ----- DNAPK_Hsap_DNAPK SIELF-YKFVPLLPGN------RSPNLWLKDVL--KEEGVSFLINTFE--G---GGCG-- TOR_Dmel_FRAP ILRSL-D----------------------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP AMHSL-Q----------------------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP VLKNL-N----------------------------------------------------- TOR2_Scer_FRAP ILQHL-G----------------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK SMILF-TQLVTLLPNI------KTPLQWVKERI--KSNGIQFIVSIAEQQG---GGV--- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP VLSSL-E----------------------------------------------------- TRRAP_Ddis_TRRAP AQRML-T----------------------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP AMDSL-R----------------------------------------------------- CC1G_00839_Ccin_ATM TM--L-S----------------------------------------------------- CC1G_08126_Ccin_ATR AGLTL-Q----------------------------------------------------- CC1G_00894_Ccin_FRAP VLRGL-H----------------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K IAATS-K----------------------------------------------------- CC1G_00331_Ccin_TRRAP AQRCI-N----------------------------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP VFVSL-G----------------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP IIQAL-T----------------------------------------------------- GK009_Glam_PIKK-Unclassified ILSCV-D----------------------------------------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK QP---------------------------------------------------------- ATR_Mmus_ATR --V-------------------------------------------KA------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM --INYFEASSEDTTQNNSPYTIGGRFQKPLHSTIDKAVRAYLWSSRNK------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR --L-------------------------------------------KA------------ DNAPK_Hsap_DNAPK QP---------------------------------------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -GGG-------------------------------------------SSNGNTSLGRIPK SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK --------AGILAQPTLVYLQGPISLRGVLQWLDLLLAALECYNTFIEKETVQGQEVLGA ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK --------SGILAQPTLLYLRGPFSLQATLCWLDLLLAALECYNTFIGERTVGALQVLGT TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK IEIGKHKDI--------------------EFWFRNLSTSLNIYLWFFSEGFFEPIQILTS SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------VLA-QV SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------HIG-TI CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK -EVQSSLL-----------------------KSVAFFLESIATHSARAVEQRFGSGA-PG ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------HCM-VH B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK -EAQSSLL-----------------------KAVAFFLESIAMHDIIAAEKCFGTGA-AG TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------VLA-QV smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK REFKSSLLSSA-----------FHTFTTQFSMLNFNSNLKTNQQQQQQQVSMFSSM---- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------MISVEI ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------WLA-DF CC1G_00839_Ccin_ATM ------------------------------------------------------VNS-VI CC1G_08126_Ccin_ATR ------------------------------------------------------AVV--- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------YMV-TL AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -----------------------------------------------------------V ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK SKWKSEVRRSIQDSRQSFGVTSFSVFREAMVTNML------------------------- FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP T---GKSV-------------T-----VIMEPHKE------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -------------------------------------LPKKLPGIYLGKCKQQLPCPDFS CG2905_Dmel_TRRAP Q---SKTV-------------S-----EVMDPHKD------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK P----PSLHEEEKYNYSKCTVL-----VRIMEFTT------------------------- ATR_Mmus_ATR ----------------STCKPF-----LFLL-TKNTPSPV-------------------- ATM_Mmus_ATM ---------------------------------NE------------------------- C47D12.1_Cele_TRRAP SRLAP-----------------------SLDKFYY------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ----TRCY-------------LSHVLSDFNFPNQK------------------------- TEL1_Scer_ATM ----------------SISERL-----VAILEFSDCVST--------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ---------------------------------NE------------------------- ATR_Hsap_ATR ----------------SVCKPF-----LFLL-KKKIPSPV-------------------- DNAPK_Hsap_DNAPK N---RTSPQEGERYNYSKCTVV-----VRIMEFTT------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP T---GKSV-------------T-----VIMEPHKE------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------TPKEIDQFNRLKCNVI-----TNLFGLYI------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP T---KIPM-------------S-----QLIEDLKM------------------------- ATMa_Spur_ATM ---------------------------------AT------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP T---DKKV-------------M-----EIMSPHKE------------------------- CC1G_00839_Ccin_ATM T---GKE---------------------VLKVGAE------------------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ---------------------T-----SALMSGRP------------------------- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP S---GRTP-------------G-----ELFLPHRE------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP T---GRTV-------------A-----SIIEPHKE------------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -----------VL-------------------------------------------QDMV SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR STNLEMIANDLLFYPDFECIAQHLDLLCFE--PNVILGLLRETEALQKVSVKVIGQL--- CG2905_Dmel_TRRAP -----------VL-------------------------------------------ADII CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK -----------TL-------------------------------------------LIAS ATR_Mmus_ATR ---------KLAFIDNLHHLCKHLDFQEDEREVKA-----------------VLGTL--- ATM_Mmus_ATM -----------AF-------------------------------------------SQFL C47D12.1_Cele_TRRAP -----------RF-------------------------------------------KEFF B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -----------IT-------------------------------------------FNMI TEL1_Scer_ATM ----------DVFISYLGTVCQWLK----------------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----------VF-------------------------------------------TQFL ATR_Hsap_ATR ---------KLAFIDNLHHLCKHLDFREDETDVKA-----------------VLGTL--- DNAPK_Hsap_DNAPK -----------TL-------------------------------------------LNTS TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -----------VL-------------------------------------------QDMV smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -----------LL-------------------------------------------L--- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -----------TV-------------------------------------------QKLL ATMa_Spur_ATM -----------LF-------------------------------------------PNLL ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----------VL-------------------------------------------ADMI CC1G_00839_Ccin_ATM -----------VL-------------------------------------------NLVV CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K -----------LR-------------------------------------------SAMM CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -----------RM-------------------------------------------LAGV AqueK043_Aque_ATM ----------------------------------------------------------FI AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -----------LL-------------------------------------------IDMI ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP PP-KKHLLR-HQPAN---A--QIGLME---GN---------TFCTTL--Q-P--RL---- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------------------------------------------ERFDA---HL---- mei-41_Dmel_ATR ---------------------VSAMRVRSPEFLEQLANLVLAAI-KAMLA-K--PL---- CG2905_Dmel_TRRAP PP-KKHLLR-HQPAN---A--QIGLMD---GN---------TFCTTL--E-P--RL---- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------------------------------------------ERFDA---HL---- DNAPK_Mmus_DNAPK PE-DCKLLE-KD-------------------------------------------LCNTN ATR_Mmus_ATR ---------------------LNLMEDPDKDVRI----AFSGNI-KYILE-S--LN---- ATM_Mmus_ATM AD-DHHQ----------------------------------------------------- C47D12.1_Cele_TRRAP EPELMRVLT-TVPTMSLAD--AGGSLD---GV---------QNYMFN--C-P--DG---- B0261.2_Cele_FRAP -----QM--------------------------------------PRPFLA---HL---- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR RP-S-------------------------------------------------------- TEL1_Scer_ATM ---------------------------------------QAIGE-KSS------------ MEC1_Scer_ATR ------------DNK---FNIWVYQSEPDSSL---------KNV-TSPFD-D--RY---- ATM_Hsap_ATM AD-NHHQ----------------------------------------------------- ATR_Hsap_ATR ---------------------LNLMEDPDKDVRV----AFSGNI-KHILE-S--LD---- DNAPK_Hsap_DNAPK PE-GWKLLK-KD-------------------------------------------LCNTH TOR_Dmel_FRAP ----------------------------------------------ETFDG---KL---- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP PP-KKHLLR-HQPAN---A--QIGLME---GN---------TFCTTL--Q-P--RL---- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ----------------------------------------------PCFDP---QL---- TOR2_Scer_FRAP ----------------------------------------------SNFDP---QL---- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ---------------------------------------FINNL-NFIYD-L--II---- DNAPK_Ddis_DNAPK -E-KYKFEQVID-------------------------------------------YGGVA SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------------------------------------------ARFDH---YL---- TRRAP_Ddis_TRRAP PK-T--P--------------------------------------LKSLS----IS---- ATMa_Spur_ATM QD-STHE----------------------------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP PP-KKHLLR-HQPAN---A--QRGLMD---SN---------TFCTTL--E-P--RL---- CC1G_00839_Ccin_ATM NP-SAM----GPNGN---A--KWTLAE---RA---------TLCEGL--E-P--LV---- CC1G_08126_Ccin_ATR ----------------------------------------------EFYSGN--TL---- CC1G_00894_Ccin_FRAP ----------------------------------------------ERFDK---HL---- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K NP-ADIL--------------------------------------LERYD----HE---- CC1G_13883_Ccin_PI4K ----------------------------------------------EVYDA---SL---- CC1G_00331_Ccin_TRRAP Y---TKPLR-ALPFL---K--QIGIME---SM---------RYCLKL--E-P--QV---- AqueK043_Aque_ATM VD-ADHS----------------------------------------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP PP-KKHLLK-HQPIN---T--QIALMD---GY---------TFCCNL--S-P--RL---- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -----T---------------------------------------NGSFYD---FL---- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -----T---------------------------------------TNRYDI---YL---- GK009_Glam_PIKK-Unclassified ----------------------------------------------STIASALAYH---- TRRAP_Hsap_TRRAP -------------------FTMD------------LNVV--------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ---------------------AQ------------AE----------------------- mei-41_Dmel_ATR ---------------------TE------------QN----------------------- CG2905_Dmel_TRRAP -------------------FTID------------LTNT--------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ---------------------AQ------------AE----------------------- DNAPK_Mmus_DNAPK LMQVLVKMICEPMSLGFNIGD--------------VQVM--------------------- ATR_Mmus_ATR ---------------------SE------------DG----------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -------------------FDFE------------KDMD--------------------- B0261.2_Cele_FRAP ---------------------AQ------------PE----------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ---------------------KQ------------LE----------------------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ---------------------SE------------DG----------------------- DNAPK_Hsap_DNAPK LMRVLVQTLCEPASIGFNIGD--------------VQVM--------------------- TOR_Dmel_FRAP ---------------------AQ------------PE----------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -------------------FTMD------------LNVV--------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ---------------------AQ------------PD----------------------- TOR2_Scer_FRAP ---------------------AQ------------PD----------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ----------------------Q------------QK----------------------- DNAPK_Ddis_DNAPK FVQLLVKCLMDPQSVGFV--------------------NNYLEEREVELSKSSRQDIRNL SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ---------------------AQ------------AE----------------------- TRRAP_Ddis_TRRAP ---------------------LQ------------TG----------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------------FTMD------------PTIP--------------------- CC1G_00839_Ccin_ATM -------------------WTSD------------PPVE--------------------- CC1G_08126_Ccin_ATR ---------------------AS------------RQ----------------------- CC1G_00894_Ccin_FRAP ---------------------AQ------------AE----------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ---------------------AQ------------TQ----------------------- CC1G_13883_Ccin_PI4K ---------------------FDVKGDFVGDTHKTLH----------------------- CC1G_00331_Ccin_TRRAP -------------------IDAS------------EE----------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -------------------FSIN------------LSVP--------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ---------------------AQ------------AD----------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ---------------------VH------------ES----------------------- GK009_Glam_PIKK-Unclassified ---------------------AS------------PK----------------------- TRRAP_Hsap_TRRAP -------------E------------------HKV----------------FYTE----- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -----------NLQ-------------------------------------ALFVAL-ND mei-41_Dmel_ATR -----------VLQ-------------------------------------QRSMLN--- CG2905_Dmel_TRRAP -------------Y------------------HKL----------------FFHE----- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -----------NLQ-------------------------------------ALFVAL-ND DNAPK_Mmus_DNAPK ----------NH------------------------------------------------ ATR_Mmus_ATR -----------FVK-------------------------------------ELFVLR--- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -------------M------------------YKR----------------YLSH----- B0261.2_Cele_FRAP -----------MLE-------------------------------------VQFMAL-HD atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ----------------------------------LLYWSLLSSARGINSKLTLSV----- TEL1_Scer_ATM ------------------------------------------------------YNK--- MEC1_Scer_ATR -----------KLR-------------------------------------LLVL----- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -----------FIK-------------------------------------ELFVLR--- DNAPK_Hsap_DNAPK ----------AH------------------------------------------------ TOR_Dmel_FRAP -----------SLN-------------------------------------SLFITL-HD SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -------------E------------------HKV----------------FYTE----- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -----------NLR-------------------------------------LLFTAL-HD TOR2_Scer_FRAP -----------NLR-------------------------------------LLFMAL-ND TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -----------ELD-------------------------------------NLFLEVLM- DNAPK_Ddis_DNAPK MSRTFKFPPLLE------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -----------NLR-------------------------------------SLFIAL-ND TRRAP_Ddis_TRRAP -----------VID------------------G------------------LTFC----- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------E------------------HKV----------------FFTE----- CC1G_00839_Ccin_ATM -------------TGWEAVAQPDFSRDGVTRKE--------------------------- CC1G_08126_Ccin_ATR -----------NIE-------------------------------------NFFHRL-Y- CC1G_00894_Ccin_FRAP -----------NVR-------------------------------------SLFIAL-ND CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K -----------LLR-------------------------------------NHFC----- CC1G_13883_Ccin_PI4K -----------SLQ-------------------------------------SGLHGL-SE CC1G_00331_Ccin_TRRAP -----------LLR-------------------------------------LLHE----- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -------------E------------------HKV----------------FFQE----- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -----------CLK-------------------------------------AIFIAF-ND SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -----------SLR-------------------------------------TLFIAL-YD GK009_Glam_PIKK-Unclassified -----------DLS-------------------------------------LSDATL-HD TRRAP_Hsap_TRRAP -LL--------------------------------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP QVFE-IRELAI------------------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -LL--------------------------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP QVFE-IRELAI------------------------------------------------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM -----VRMLAAGSVNRLFQDMRQGDFSRSLKALPLKFQQTSFNNAYTTAEAGIRGLLCDS C47D12.1_Cele_TRRAP -LL--------------------------------------------------------- B0261.2_Cele_FRAP EKLE-MQQACV------------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -ID--------------------------------------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR -KK--------------------------------------------------------- ATM_Hsap_ATM -----VRMLAAESINRLFQDT-KGDSSRLLKALPLKLQQTAFENAYLKAQEGMREMSHSA ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP EIFE-IRELAM------------------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -LL--------------------------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ESFN-IQSVAM------------------------------------------------- TOR2_Scer_FRAP EIFG-IQLEAI------------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR DLLKLSSTVEI------------------------------------------------- DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ELFE-IRELAI------------------------------------------------- TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM -----VRMHMATAVGCLFNTPG-TQ------PYKTETQNQAFNLVYQYVEEAMQ-ISDDF ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -LM--------------------------------------------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR QVFE-------------------------------------------------------- CC1G_00894_Ccin_FRAP EVMA-NREAAV------------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K --DE-KRLIGI------------------------------------------------- CC1G_00331_Ccin_TRRAP -AL--------------------------------------------------------- AqueK043_Aque_ATM -----VRLHLARNITVLFPETNTP----------LEHMNNFNDLKDMLRKST-L-VKSNL AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -LI--------------------------------------------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP QSFE-VRKLSI------------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP DNIE-IRILAV------------------------------------------------- GK009_Glam_PIKK-Unclassified ALVV-------------------------------------------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------THWDFCQELYESIEFKKLTYNNEDAIQNSNALIVQMLIAIFLRSSFHQEIALKE CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM QNPDLLD-----------------------EIYNRKSVLLMMIAVVLHCSPVCEKQALFA C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ENPETLD-----------------------EIYNRKSVLLTLIAVVLSCSPICEKQALFA ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM GEAESKE-----------------------ETKNRTASLLRTLANVALSSHVCEKKTIFA ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM DEHSSED-----------------------ESVNRVASMLCTLQSVACSARSCEYHVISL AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------CTVGRLSSMN---------------------------P-AF----VMP mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM LLHHCALRRLTEKDIERCSKS-------------------------------ISEELALP CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------CTVGRLSSMN---------------------------P-AF----VMP DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM LC---------------------------------------------------------- C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------TLLGRLAELN---------------------------P-AL----VLP atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM LC---------------------------------------------------------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------VTIGRLSSIN---------------------------P-AY----VMP SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------ELVGRLSSVN---------------------------P-AY----VIP TOR2_Scer_FRAP ------------KIIGRLSSVN---------------------------P-AY----VVP TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------EYLHRISTLKSNEQLLESLFKLSTIVTNHSTIFNLTKY-AE----IIN DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------TVIGRLTIRN---------------------------P-AY----VMP TRRAP_Ddis_TRRAP -----------------LSQKP---------------------------SPLI----EIG ATMa_Spur_ATM LL---------------------------------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------GLIGRLAKHN---------------------------P-AY----VMP CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K -----------------MSEVS---------------------------L-AF----TLP CC1G_13883_Ccin_PI4K ------------STISVVTRLA---------------------------L-EF----QME CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM LV---------------------------------------------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------VMAGKLSDKN---------------------------A-AY----VCP SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------KLIGRLCSLN---------------------------P-AL----VTP GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP FL---------------------------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ILA--------------------------------------------------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP FL---------------------------------------------------------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP RL---------------------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP KL---------------------------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP SI---------------------------------------------------------- TOR2_Scer_FRAP SL---------------------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR SI---------------------------------------------------------- DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP SL---------------------------------------------------------- TRRAP_Ddis_TRRAP A----------------------------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP SL---------------------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K LL---------------------------------------------------------- CC1G_13883_Ccin_PI4K EV---------------------------------------------------------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP AL---------------------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP EI---------------------------------------------------------- GK009_Glam_PIKK-Unclassified -AILFLTVLYADTEALAGAKTLKKVELVTSSIKAIKELVALPIFANVKPHKLFSEGIESY TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------RK------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM -----------SFLLIKNSSCSESEGQNFKEHLQLLSENLSY-SQLNA------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------RK------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ----------------KSVKENRLEPHLVKKVLEKVSESFGC-RSLEDFMISHLDYLVLE C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ----------RL------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ----------------KSVKENGLEPHLVKKVLEKVSETFGY-RRLEDFMASHLDYLVLE ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ----------RT------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ----------RK------------------------------------------------ TOR2_Scer_FRAP ----------RK------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ----------KV------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------RK------------------------------------------------ TRRAP_Ddis_TRRAP ----------DT------------------------------------------------ ATMa_Spur_ATM ----------------LTTKINKIPSSVMKKVLSCIAEGMSHCSSGPELATLHLGFLVYQ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----------RK------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ----------RL------------------------------------------------ CC1G_13883_Ccin_PI4K ----------TR------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ----------------TSTGQGHMNSDIVKKVIRRISEYLG-YANEICLLEEMLSYLVSQ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------RR------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------RH------------------------------------------------ GK009_Glam_PIKK-Unclassified NGATAHIFRLLS------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------------------------M--LIQILTELEH------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ----TDVDLDLDILCYVISMLHDPQEMMR------------------------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------------------------M--LIQILTELEH------------------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM WLNLQDTEYS-------------------------------------------------- C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ----------------------------M--LLETLSQMQQ------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM WLNLQDTEYN-------------------------------------------------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ----------------------------T--MIELITDLKY------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ----------------------------I--LLELLTKLKF------------------- TOR2_Scer_FRAP ----------------------------T--LLELLTQLKF------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ----------------------------I--SFSLVCWLPCSYYVNERVDIVLSTLSLNK DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------------------------T--LIQLLTELEF------------------- TRRAP_Ddis_TRRAP ----------------------------VR----VLQECLN------------------- ATMa_Spur_ATM WLQ---ESYE-------------------------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----------------------------A--LIQLLTELEY------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ----------------------------TDNKVQFLLSLEN------------------- CC1G_13883_Ccin_PI4K ----------------------------L--TIS-------------------------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM WMN----EGT-------------------------------------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------------------------H--LQQLLTDMEH------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------------------------L--ILVLLTELRL------------------- GK009_Glam_PIKK-Unclassified ----------------------------V--IFILMTAL-F------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM --------------------------------------ILEEFTEVLGEKLLCNHYSSSN MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR SLVNSTTTTTTTTTTTTTTTTTTATTNTTTTTATTTDKSSSQQNVGESNKN--------- DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ----------------------------------------VLTAIA-------------- CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ----------------------------------------MKEAYT-------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM QAMLLLTSYIEAIRPQWLSYPEQPLNSDCNDILDWIISRFEDNSFT-------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ----------------------------------------MKEAYT-------------- DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -------------------------NPTIVSSSPILVNISSDTSSSMGDSQAISASQQQQ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR RNNNNNNKGEKYLSKLDQNYLINVIKLLPVFISNMSPVNSLATISTNHQYQIMCNDIIKR DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR LESIIDLNVTSLILDMVGVIGGSLYCLKEGYCFFENLNRCTYLNNNNNNNNNNNNNNNNN DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR NNNNNNIQEQNNLIIINNSILLQRFTDTKNNRIKIDPLLSNYNNLVGCGIFEGVWLPLCS DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR CKCVTVSSVLNTNIVDLNLKPYRPIHKSPPSNNNNNNNEKDETIMDIDKTNNNEQILILE DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR SKYKENILFSKLFLEYHDGQNSDLDNDTSMMTSGGGDGDHDSSIKYFYLGFTFKNILIHN DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR SPLPSTSIEGFFKFYLNLLSANRNDIIRKSVIKIIISMLKFNYQTNPDVLTNFFYQLHPL DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -------------------------------------------------------HME-- CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR -------------------------------------------------------HAQIA ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM -------------------------------------------------------GVAPT MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -------------------------------------------------------HAQIS DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR YSNKSEREDILFSILYLLKKIANLIIQSQKDQYILNNSLNNNNNNNNNNNVQQLSSSSSS DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR -----------------------------------------------------------G CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP --NLC-EAEDSA----LTK-LPCYKS--------------LPSLVPLRIAALNALAAC-- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR --------------------DNEIWL--------------FHWFKM---TFFFLV----- CG2905_Dmel_TRRAP --TLS-EAEDAT----LAK-LDCYKN--------------VPNLIPLRTSALRALAAC-- CG6535_Dmel_ATM --------------------------------------------------LFGSLAIC-- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ----------------------------------------------LPSICVNLLKALRK ATR_Mmus_ATR RNNEL-KDTLIL----TTGDIGRAAK--------------GDLIPF---ALLHLL----- ATM_Mmus_ATM ---------------------------------------------------LSSFPFM-- C47D12.1_Cele_TRRAP --DIA-QTDTFTL----NQ-RNAFKKCETCPSHFLPPFPITTHIDSMRASALQCLVIA-- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR --FICQEMSAAS----VSM-SSISPN--------------PS------------------ TEL1_Scer_ATM VNLSM-LLLSLL----QNHDLSHGSI--------------RGGKQR---VFATFI----- MEC1_Scer_ATR --FNK-TERGTL----LKYRVNQLSP--------------GFFQR--------------- ATM_Hsap_ATM ---------------------------------------------------LSSFPFI-- ATR_Hsap_ATR RNNEL-KDTLIL----TTGDIGRAAK--------------GDLVPF---ALLHLL----- DNAPK_Hsap_DNAPK ----------------------------------------------LPDVCVNLMKALKM TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP --NLC-EAEDSA----LTK-LPCYKS--------------LPSLVPLRIAALNALAAC-- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR HNNQL-NNNNTT----TTNNDSITWQ--------------DKIYSN---DFILII----- DNAPK_Ddis_DNAPK ----------------------------------------------IINNIIKLLIQI-K SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ---VA-GDESSPTQQSQIK-SSSAKS--------------ISATNNLRVCGVEMVATA-- ATMa_Spur_ATM ---------------------------------------------------IREFPYG-- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --NLC-ETEDSG----LVK-LPCYKA--------------VPSLVPLRISALNALAAC-- CC1G_00839_Ccin_ATM ------------------------RSL--------------PSVT--------------- CC1G_08126_Ccin_ATR CRHSI-KETLLI----SVGSLGKTAN--------------PFILGS---TLCLLI----- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ---IC-NR-----------------L--------------LVVPRPARVSALRA------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --ALA-DAEDVQ----LVGPRTTRSS--------------ALEILKLRESCIKLLTAA-- AqueK043_Aque_ATM ---------------------------------------------------IDGFPYT-- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP --TLCGEGDDAA----LAK-SPCYKG--------------VQSLVPLKISGLAALAAC-- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP N-------Y------LP-------------------------------Q--------SRE SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP H-------Y------IS-------------------------------DI------GYKE CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK SPYRDMLE--------T-------------------------------H--------LKE ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP Y-------DRMKKQYIDKGIELGDEHKMIEILALRSSKITVDQVYESDE--------SWR B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK SPYKDILE--------T-------------------------------H--------LRE TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP N-------Y------LP-------------------------------Q--------SRE smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK PKYNDILH--------K-------------------------------E--------LME SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP M-------T------CP-------------------------------DFLQFECLEFKN ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP R-------Y------IP-------------------------------Q--------ARE CC1G_00839_Ccin_ATM ------------------------------------------------D--------AKE CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP MPITDFFGK------IP-------------------------------H--------TRQ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP T-------Y------LT-------------------------------E--------MRE ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP KIIAAL--------FKALNSTNSELQEAGEACM---RKFLEGA-TI-------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -------------------SGIGRIKEQS------------------------------- mei-41_Dmel_ATR ---------------HTRSLVAQEAVLAAT---EMCASQGLQTIHL-------------- CG2905_Dmel_TRRAP KIINII--------FKVMESDKSELQTTAFHCM---KHFITGV-TL-------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -------------------SGIGRIKEQS------------------------------- DNAPK_Mmus_DNAPK KVTVQS--------VE-------------------------------------------- ATR_Mmus_ATR --HC-L--------LSKSASVSGAAYTEIR---ALVAAKSVKLQNF-------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP RLMTVL--------LRAVTD-------------------------R-------------- B0261.2_Cele_FRAP -------------------SGQARLEQHS------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM --KC-LQKLDSSNII--------------------------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR --HC-L--------LSKSASVSGAAYTEIR---ALVAAKSVKLQSF-------------- DNAPK_Hsap_DNAPK KITAQS--------IE-------------------------------------------- TOR_Dmel_FRAP -------------------SGMSRNKEQS------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP KIIAAL--------FKALNSTNSELQEAGEACM---RKFLEGA-TI-------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -------------------STSSREKEET------------------------------- TOR2_Scer_FRAP -------------------SNMPKKKEES------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR --FCTL--------IE-----------------NLSRQTTIKVNSIETIEFIAKKLNQTP DNAPK_Ddis_DNAPK YILPNN------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -------------------SGDGRNKEES------------------------------- TRRAP_Ddis_TRRAP RIIRMF--------FKVVTARNKEMAMAAKRGL---ANSIQQQ-RL-------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP RIFKIL--------FNALNSNVSELQEAGAKCM---EKFIAGQ-PV-------------- CC1G_00839_Ccin_ATM ELRRNI--------LRAIWS---------------------------------------- CC1G_08126_Ccin_ATR --------------LQLGQSNLLLHSLACTQLLNISRHHKKSIYSL-------------- CC1G_00894_Ccin_FRAP -------------------STVMRNREDC------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ----------------ELTALN-------------------------------------- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP RVTSVY--------FKSLYSPSAEVKEAAHTGL---RMVLAHQNRL-------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP RIFGAL--------YKAINSNSVELQNAGKEAM---RKFMSDTSQS-------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------------------SADSKSKEES------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -------------------TTENNKRATS------------------------------- GK009_Glam_PIKK-Unclassified --------------------SFSRDVLHR------------------------------- TRRAP_Hsap_TRRAP -------EVDQI---------HTHMRPLL----------MMLG----------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -------WNWYKRDALDLTVRLALNVYLL----------DGVR----------------- CG2905_Dmel_TRRAP -------EKEKV---------QSAMRPLL----------LKLG----------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR -------FSQYK---------KPICQFLV----------ESLH----------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -------ETPEI---------AEKLHPSL----------LKVSPISTIIIATFGASYIRN B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ----------------------NIMNSISSYMAQVSYKNQSII----------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -------FSQYK---------KPICQFLV----------ESLH----------------- DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -------EVDQI---------HTHMRPLL----------MMLG----------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR KTLMMTNMAQYI---------N---PRII----------ENLY----------------- DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -------HRDLL---------QTCLRPVL----------SNIT----------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------EMELV---------HTSVRPLL----------LMLG----------------- CC1G_00839_Ccin_ATM -------NSEKE---------GFVGLLGY----------IRSQVADASILD--------- CC1G_08126_Ccin_ATR -------LSPHF---------DRVVKIVF----------ERLS----------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -------PKELL---------QSGLRPIL----------MNLA----------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -------DIELV---------HSALRPLL----------MMLG----------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ---------DYRS-------LTLN------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ---------DHRN-------LSIP------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ---------SSQM-------TALPSAPCQSSEI--------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ISGAGDDSDSDRH-------ISYN------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ---------FYEI-------KSLFGPPQQSIEKSAFYSLAMSMLSLVSYPSLVFSLEDMM MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ---------SSQM-------TALPNTPCQNADV--------------------------- DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ---------DYRS-------LTLN------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ---------TNR------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ---------DPKS-------LSVP------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ---------DHRT-------LNLN------------------------------------ CC1G_00839_Ccin_ATM ---------NPTTLAMDADDGGAW------------------------------------ CC1G_08126_Ccin_ATR ----------TQP----------------------------------------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ---------DPKR-------LTVS------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ---------DFRN-------LNPT------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -------VVNRLTSVTRLFP---------------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ----FTR-------SLRALT---------------------------------------- CG2905_Dmel_TRRAP -------AIKRLSYFTQIFP---------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK -----------------ELC---------------------------------------- ATR_Mmus_ATR RKQDVAHHREMALNTLSEIA---------------------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -------DIMKFKCLVELNP---------------------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM TYSGFNHTRAFIQQALNKITVAFRYQNLTELFEYCKFDLIMYWFNRTKVPTSKLEKEWDI MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR RKQDVAHQREMALNTLSEIA---------------------------------------- DNAPK_Hsap_DNAPK -----------------ELC---------------------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -------VVNRLTSVTRLFP---------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -------------QSLVELC---------------------------------------- DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -------FLQGLSRLLELLS---------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------VIQRLHSLTQLFP---------------------------------------- CC1G_00839_Ccin_ATM -------AVRTSETSTSKLP---------------------------------------- CC1G_08126_Ccin_ATR -------------TLLTELC---------------------------------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -------GLEGLARVLSLLN---------------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -------LLQRLTHMVELFP---------------------------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP N----------------------------------------------SFNDKFC-----D SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR KMLGFTCVQEFTCKYHRLLTAMVLPHCIVNP--L--CKGVLVLIAKQMQKHIGT-----L CG2905_Dmel_TRRAP Q----------------------------------------------MFNEKLS-----E CG6535_Dmel_ATM -NRTASWYSLSGESLF----KCLNFHIDPEMR--PSMDSRIQSMT-TLQTKHSR-----V CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK S-INLCS---SGARQE----RSKLLSILSAC--KQL---HKAGFSHVISPSQST-----A ATR_Mmus_ATR NVFDFPDLNRFLTRTL----QVLLPDLAAKA--SPAASALIRTLGKQLNVSRRE-----I ATM_Mmus_ATM -LLNYTSIEDFYRSCY----KILIPHLVIRS-----HFDEVKSIANQIQKCWKS-----L C47D12.1_Cele_TRRAP K----------------------------------------------ILVTKMA-----V B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM SLFGFADIHEFLGR-----YFVEISAIYFSQ--GF---NQ-------------------- MEC1_Scer_ATR ------------------------------------------------AGNDFK-----L ATM_Hsap_ATM -LLNYTNIEDFYRSCY----KVLIPHLVIRS-----HFDEVKSIANQIQEDWKS-----L ATR_Hsap_ATR NVFDFPDLNRFLTRTL----QVLLPDLAAKA--SPAASALIRTLGKQLNVNRRE-----I DNAPK_Hsap_DNAPK A-VNLYG---PDAQVD----RSRLAAVVSAC--KQL---HRAGLLHNILPSQST-----D TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP N----------------------------------------------SFNDKFC-----D smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR RYFLGIGLNQFLISSL----PTVIPVLIFKS--SNN---ILNCLKDELKDLKELCGQDYL DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP N----------------------------------------------CFNAALG-----E ATMa_Spur_ATM -VLGCSSSQEFLSKHH----TAIIPHLVNLK-----KLGTVKSIAGELKQDWKD-----L ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP N----------------------------------------------AFNEKLC-----E CC1G_00839_Ccin_ATM G----------------------------------------------EKNQELC-----R CC1G_08126_Ccin_ATR R-LMQLNIEEFISRHH----AKALPDVLLRC--DMK---GVDLIAHSLGKNRST-----T CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP N----------------------------------------------YFKVEIG-----H AqueK043_Aque_ATM -LLSLDNINEFYRKYY----RSVVPHILA-T-----DRDSLQSISDATLLSKED-----L AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP T----------------------------------------------SFNEKMC-----E ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ---MKISTGDLLRKMI----PYVLPKLILDQQHDERAPQTLNTLAHLLQTSLPL-----V DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP Q----------------------------------------MMQHLRKWMEVVVITHKGG SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR F----------------------------------------SISFLRIYTH--------- CG2905_Dmel_TRRAP Q----------------------------------------ILQHCSKIMEIFVSEYKST CG6535_Dmel_ATM L----------------------------------------VDIFG----R--------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK L-------------------------------------------NHSVGMRLLSLVYKGI ATR_Mmus_ATR L----------------------------------------INNFKYIFSH--------- ATM_Mmus_ATM L----------------------------------------VDCFPKILVH--------- C47D12.1_Cele_TRRAP NLANQMVKYKMSDKISRILSVPSSFTEEELDDFEAEKMKGIRELD--------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM LIIFPLIDVIYKYET--------------------------------------------- atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR I----------------------------------------LNEASVSIQ---------- ATM_Hsap_ATM L----------------------------------------TDCFPKILVN--------- ATR_Hsap_ATR L----------------------------------------INNFKYIFSH--------- DNAPK_Hsap_DNAPK L-------------------------------------------HHSVGTELLSLVYKGI TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP Q----------------------------------------MMQHLRKWMEVVVITHKGG smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR M----------------------------------------GLIFEYIFIH--------- DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP K----------------------------------------LFEYLKKFEEAGKLSYLAN ATMa_Spur_ATM L----------------------------------------KSSFPRTIAS--------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP Q----------------------------------------MLGHLKKWLETTVISQKNG CC1G_00839_Ccin_ATM ----------------------------------------LVEGQLIFTIRVAALSSLLG CC1G_08126_Ccin_ATR I----------------------------------------LDSLDKILVP--------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP K----------------------------------------LLEHFRVVADPQSLQATAR AqueK043_Aque_ATM I----------------------------------------KESLPVTMAS--------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP S----------------------------------------LLAHLKRWVEVIVNNSQSK ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR L----------------------------------------LEWCHKVLSV--------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP QRSDGNESISECGRCPLSPFCQFEEMKICSAIINLFHLI------------PAAPQTLVK SMG1_Hsap_SMG1 --------------------------------ALRSHMS--------------------- FRAP_Hsap_FRAP -------------------------------------------------------ARMLG mei-41_Dmel_ATR -----------------------------------VFLT------------EEPELA--- CG2905_Dmel_TRRAP SPNVNFFAS----------SKGGEYEQKIVILIEMFFYI------------SAS-VKYIE CG6535_Dmel_ATM -----------------------------------LKTNC-------------------- CG4549_Dmel_SMG1 --------------------------------QLPLHLT--------------------- FRAP_Mmus_FRAP -------------------------------------------------------ARMLG DNAPK_Mmus_DNAPK VPAEERQCL--------------------------------------------------- ATR_Mmus_ATR -----------------------------------LVCS------------CSKDEL--- ATM_Mmus_ATM -----------------------------------ILPYFAYEGTRDSYVSQ-------- C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP -------------------------------------------------------AKMIA atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----------------------------------ILPYFAYEGTRDSGMAQ-------- ATR_Hsap_ATR -----------------------------------LVCS------------CSKDEL--- DNAPK_Hsap_DNAPK APGDERQCL--------------------------------------------------- TOR_Dmel_FRAP -------------------------------------------------------AKMLD SMG1_Mmus_SMG1 --------------------------------ALRSHMS--------------------- TRRAP_Mmus_TRRAP QRSDGNESLSECGRCSLSPFCQFEEMKICSAIINLFHLI------------PAAPQTLVK smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -------------------------------------------------------ASLLC TOR2_Scer_FRAP -------------------------------------------------------ATLLC TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -----------------------------------A---------------TSVENL--- DNAPK_Ddis_DNAPK -SNNNNNSSSSGNNKSMFSLIDIRQLINTEGTDRLIHLI------------HS-YQILYK SMG1_Ddis_SMG1 --------------------------------PYKLLIM--------------------- Tor_Ddis_FRAP -------------------------------------------------------ARLLG TRRAP_Ddis_TRRAP K------------------YRDSEEVKICASIIDIFHLL------------PPA-AKLLD ATMa_Spur_ATM -----------------------------------LLPLLAQSREHSERAEE-------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------------QKSTDSLKICTAILNIFHAI------------PAASAKILE CC1G_00839_Ccin_ATM DSSD-------------------VKDFQQFLNGLLNSVE------------ESAPWCLLV CC1G_08126_Ccin_ATR -----------------------------------ILLL------------PTVPQT--- CC1G_00894_Ccin_FRAP -------------------------------------------------------TRLLT CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP L-----------------PFSETEGVPKLVRLANIFHLL------------PSAANVFLD AqueK043_Aque_ATM -----------------------------------ILKAMAHSDGDEDSKRQ-------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------PVRRGEEVQVCILILDMFHML------------PASSFKLFD ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -----------------------------------LLLR------------ADGREL--- DNAPK_Smoe_DNAPK -------------RTLSMDASVGPQLAV-------------------------------- FRAP_Smoe_FRAP -------------------------------------------------------AILLG SMG1_Smoe_SMG1 --------------------------------KEEGNFV------------TKR------ GK008_Glam_FRAP -------------------------------------------------------NELIV GK009_Glam_PIKK-Unclassified -------------------------------------------------------VQLLH TRRAP_Hsap_TRRAP -P----------------LLEVVMKTERAMLIE-------------------------AG SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -H----------------LVSN--------APR-------------------------LI mei-41_Dmel_ATR -------------------------------NS-------------------------CI CG2905_Dmel_TRRAP -K----------------LCQLVLKTEKNLMIE-------------------------AS CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -H----------------LVSN--------APR-------------------------LI DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR -------------------------------ER-------------------------AL ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ---------------------MIGHTVKMLAG---------------------------- B0261.2_Cele_FRAP -Q----------------LAKQ--------SPK-------------------------FM atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------DIRIVMIQRKSL-----------------------------I TEL1_Scer_ATM --------------------------------KWILDMLHAITGNGDAYLVDNSYYLCIP MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -------------------------------ER-------------------------AL DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP -H----------------LVIS--------TPR-------------------------LI SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -P----------------LLEVVMKTERAMLIE-------------------------AG smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -T----------------LIRS--------SKD-------------------------VA TOR2_Scer_FRAP -T----------------LINS--------SDE-------------------------VA TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -------------------------------TS-------------------------CI DNAPK_Ddis_DNAPK YN----------------LLDS-------ILLE-------------------------NY SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -H----------------LISA--------SEK-------------------------LI TRRAP_Ddis_TRRAP -S----------------TIILTIRLEQSLCKE-------------------------VT ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -H----------------LLTLVIKAEGALTME-------------------------VG CC1G_00839_Ccin_ATM VPILLREIDIGSLKVNEDIALSLLNAIARCLK---------------------------- CC1G_08126_Ccin_ATR -------------------------------NK-------------------------AV CC1G_00894_Ccin_FRAP -L----------------LVSA--------TQR-------------------------LI CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -P----------------LVNLIIQTETQMHFS-------------------------TV AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -P----------------LISLCIKAEKALGTE-------------------------LS ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -------------------------------MA-------------------------AL DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -S----------------LIRA--------CET-------------------------LI SMG1_Smoe_SMG1 -------------------------------PL-------------------------ER GK008_Glam_FRAP -K----------------IFKF--------CGS-------------------------IV GK009_Glam_PIKK-Unclassified -T----------------LVSS--------KKK-------------------------GS TRRAP_Hsap_TRRAP S---PF-------------------------REPLIK----------------------- SMG1_Hsap_SMG1 ----------------------------------K------------------------- FRAP_Hsap_FRAP R---PY-------------------------MEPILK----------------------- mei-41_Dmel_ATR E---LV--------------------------------VSCTQS---------------- CG2905_Dmel_TRRAP S---PY-------------------------REALIK----------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ----------------------------------L------------------------- FRAP_Mmus_FRAP R---PY-------------------------MEPILK----------------------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR H---YL--------------------------------KNETEI---------------- ATM_Mmus_ATM --------------------------------------KRETATKVYDTLKG-EDFLGK- C47D12.1_Cele_TRRAP CPVTTF-------------------------TEQIIV----------------------- B0261.2_Cele_FRAP R---PY-------------------------VGSLMI----------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR T---ET-------------------------FAQLVQ----------------------- TEL1_Scer_ATM L---AF--------------------------------ISGGVN---------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM --------------------------------------QRETATKVYDMLKS-ENLLGK- ATR_Hsap_ATR H---YL--------------------------------KNETEI---------------- DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP S---SY-------------------------MNPILK----------------------- SMG1_Mmus_SMG1 ----------------------------------K------------------------- TRRAP_Mmus_TRRAP S---PF-------------------------REPLIK----------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP K---PY-------------------------IEPLLN----------------------- TOR2_Scer_FRAP K---PY-------------------------IDPILD----------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR I---CF--------------------------------CRFADF---------------- DNAPK_Ddis_DNAPK N---EQ-------------------------SEQ-------------------------- SMG1_Ddis_SMG1 ----------------------------------G------------------------- Tor_Ddis_FRAP K---PY-------------------------VEPILK----------------------- TRRAP_Ddis_TRRAP S---PY-------------------------REPLIR----------------------- ATMa_Spur_ATM --------------------------------------EKERAAWAVQCLEELKQAIGQE ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP S---PF-------------------------REPLLK----------------------- CC1G_00839_Ccin_ATM TYNHSY-------------------------NTEMRC----------------------- CC1G_08126_Ccin_ATR A---FL-------------------------IGIFNEDSRDAKI---------------- CC1G_00894_Ccin_FRAP K---PY-------------------------AIPMLR----------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP N---PF-------------------------SEPLAK----------------------- AqueK043_Aque_ATM --------------------------------------AKDTNEYILSVIS-------KE AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP S---PF-------------------------REPLLK----------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR H---FY--------------------------------EAQTGS---------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP T---PY-------------------------VIPIHK----------------------- SMG1_Smoe_SMG1 E---KH-------------------------WRSV------------------------- GK008_Glam_FRAP L---PY-------------------------VPMVYS----------------------- GK009_Glam_PIKK-Unclassified A---PAEMPISIFANLSNYTGFLFRITSLCHMKPLLG----------------------- TRRAP_Hsap_TRRAP ----FLTRHPSQTVELFM--MEATLNDP-------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----ALILK--------------------------------------------------- mei-41_Dmel_ATR SLQQLMNADVKQTVAELLIYF--NRN-P-------------------------------- CG2905_Dmel_TRRAP ----FLQRFPTETVDLFL--TESLMIDP-------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----ALILK--------------------------------------------------- DNAPK_Mmus_DNAPK ----------------------------QSLDPSCKSLANGLLELAFGFGGLCDHLVSLL ATR_Mmus_ATR ELGSLLRQDFQGLHNELLLRI--GEH-Y-------------------------------- ATM_Mmus_ATM QIDQ-------------------------------------------------------- C47D12.1_Cele_TRRAP ----DISRFAAHFE---------------------------------------------- B0261.2_Cele_FRAP ----AMIPK--------------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ----FL-----------A--FENNRNTT-------------------------------- TEL1_Scer_ATM ELIFDILPQISG------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM QIDH-------------------------------------------------------- ATR_Hsap_ATR ELGSLLRQDFQGLHNELLLRI--GEH-Y-------------------------------- DNAPK_Hsap_DNAPK ----------------------------PSLDLSCKQLASGLLELAFAFGGLCERLVSLL TOR_Dmel_FRAP ----ALVPK--------------------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ----FLTRHPSQTVELFM--MEATLNDP-------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ----VLLPK--------------------------------------------------- TOR2_Scer_FRAP ----VILPK--------------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR NQDAVVSNLPKSFINSLILNL--ANGDG-------------------------------- DNAPK_Ddis_DNAPK -GIQDLPKSSLE-FSEFIFDY--LFNNCENLSPSKLLISKELIQLALTIGIKPIKLLSLI SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----ALLPK--------------------------------------------------- TRRAP_Ddis_TRRAP ----FLAKYPQRTIEIFM--GQ----LP-------------------------------- ATMa_Spur_ATM TLNA-------------------------------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----YLLRYAQQTVDLFL--QENNLKNH-------------------------------- CC1G_00839_Ccin_ATM ----LATRALASTF---------------------------------------------- CC1G_08126_Ccin_ATR SLQTILPGHTTSVLTELVIRM--GVDDP-------------------------------- CC1G_00894_Ccin_FRAP ----VLLQK--------------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ----MLLQR--------------------------------------------------- CC1G_00331_Ccin_TRRAP ----YLDRYPVEGIDFLV--R--NLQLP-------------------------------- AqueK043_Aque_ATM TLNT-------------------------------------------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ----FTLRFTSLSMEFFL--S--HLSDI-------------------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR DAREIFAAVLPALLDELVWFL--GDTSN-------------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----ALVAR--------------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----AVMGL--------------------------------------------------- GK009_Glam_PIKK-Unclassified ----SICYR--------------------------------------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK LNSAMLSTQYLGSSQR----------------------NISFSHGEYFYSLFSEVINSEL ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK LNPAVLSTASLGSSQG---------------------SVIHFSHGEYFYSLFSETINTEL TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK INPNVQNTTTTTTT-TSTTTTTTTTTTSTNNNNDNNNEFIKDIHDIFYKTLFTE-INNYI SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ----------------QWSRMF-----------M-SFLKH--K----------DA-RPLR SMG1_Hsap_SMG1 ---------------------------------------A--PSNT-FH----------- FRAP_Hsap_FRAP -------------------------------------------------LKDPDP-DP-- mei-41_Dmel_ATR -------------------TFVMR--------SFQ------------------------- CG2905_Dmel_TRRAP ----------------QWNRLF-----------I-YLLKH--E----------TG-VSFR CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ---------------------------------------T--GGES-SM----------- FRAP_Mmus_FRAP -------------------------------------------------LKDPDP-DP-- DNAPK_Mmus_DNAPK LKNLDIAVSRLMESSSDNPKMV-----------ST------------------------- ATR_Mmus_ATR -------------------QQVFN--------GLS------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP -------------------------------------------------LRNDQ---K-- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ----------------SFWKFC-----------S-DHCDFKDE--------------DIR TEL1_Scer_ATM -----------------------KTTVKYHKKYRL------------------------- MEC1_Scer_ATR -----------------------------------TCFKT----------------NNIT ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -------------------QQVFN--------GLS------------------------- DNAPK_Hsap_DNAPK LKNLDLAVLELMQSSVDNTKMV-----------SA------------------------- TOR_Dmel_FRAP -------------------------------------------------LHEPE---S-- SMG1_Mmus_SMG1 ---------------------------------------A--PSNT-FH----------- TRRAP_Mmus_TRRAP ----------------QWSRMF-----------M-SFLKH--K----------DA-RPLR smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -------------------------------------------------FQDT------- TOR2_Scer_FRAP -------------------------------------------------CQDA------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -------------------QQAK-K-------ALD------------------------- DNAPK_Ddis_DNAPK SNNFQLF-LPLLANRIIETNQI-----------HK------------------------- SMG1_Ddis_SMG1 ---------------------------------------S--TSQPFFN----------- Tor_Ddis_FRAP -------------------------------------------------LRDS------- TRRAP_Ddis_TRRAP ----------------QFNLIF-----------R-LILKH--Q---------PLS-KP-- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----------------QLSRMF-----------N-YLLKH--E----------LA-EPLR CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ----------------QSRHQA-----------LNAV----------------------- CC1G_00894_Ccin_FRAP -------------------------------------------------ANDP------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -------------------------------------------------LRSA------- CC1G_00331_Ccin_TRRAP ----------------RTVRTF-----------R-SALQA--K----------VS-PNLE AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ----------------TISRIL-----------Q-YFLKH--K----------DG-KPLK ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -------------------DEAV-KRSARVGPMIQ------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------------------------------------------------LSEGSGGSG-- SMG1_Smoe_SMG1 ---------------------------------------L--SANR-FALQLS------- GK008_Glam_FRAP -------------------------------------------------ISKDC--D--- GK009_Glam_PIKK-Unclassified ---------------------------------------E-------------------- TRRAP_Hsap_TRRAP DVL--AAN-------PNR-FIT--------L-LLPGGAQTAVRPGSPSTSTMRLDLQFQ- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -------NPGVINNVLATI----------------------------------------- mei-41_Dmel_ATR ------S--------LLQ-LSIG--SLEELSSQTA----------------NAEFANFI- CG2905_Dmel_TRRAP AVI--KSSR------YNN-LIH--------Y-LNT-HT--------EFPEALKYEIQHQ- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -------NPGVINNVLATI----------------------------------------- DNAPK_Mmus_DNAPK --------------------------------VLNGMLDTSFR--------DRAVQKHQ- ATR_Mmus_ATR ------I--------LAS-FASSDDPYQGPRDITS----------------PELMADYL- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP -------YAEVTAQVLNAV----------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR TVI--SSY-------RKQVFMH----------LLLVSAREFLNPRNPSMIVEQLRATYE- TEL1_Scer_ATM ------L--------MLKWIIRFTDLG--------------------------------- MEC1_Scer_ATR RLTSWTV--------ILG-RL---------------------A--------CLESEKFSG ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------I--------LAS-FASSDDPYQGPRDIIS----------------PELMADYL- DNAPK_Hsap_DNAPK --------------------------------VLNGMLDQSFR--------ERANQKHQ- TOR_Dmel_FRAP -------NPGVILNVLRTI----------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP DVL--AAN-------PNR-FIT--------L-LLPGGAQTAVRPGSPSTSNMRLDLQFQ- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -------SSTVASTALRTI----------------------------------------- TOR2_Scer_FRAP -------SSAVASTALKVL----------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------Y--------VSQ-F------------VGG----------------DMTFDKFL- DNAPK_Ddis_DNAPK --------------------------------VLN---DVCIM--------KQQQQPNR- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -------NPRVASCVLAAL----------------------------------------- TRRAP_Ddis_TRRAP --------IVEELANTYSIWLE--------A-HLK----------SPS-----ADIRFH- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP SAI--QKN-------PSK-LIN--------L-AFSK-SQPPARP-TNTAEKFLLELQYQ- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ----------------KK-VETA--LQKGTI-SIS-------Q--------KANPSEFL- CC1G_00894_Ccin_FRAP -------NPAVAANVLMCL----------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -------EPTVEAAIAYNL----------------------------------------- CC1G_00331_Ccin_TRRAP REL--VS--------RTP-ILA--------P-RLS-------G--------GADQNQMR- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP EHL--YSN-------PQK-LID--------A-TFR---QPAAGT-DDASIQKKAELQYQ- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------E--------VAR-I------------ISG----------------SDDLPSFL- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------NIGVVSGVMATV----------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -------DEYLLITSLTTL----------------------------------------- GK009_Glam_PIKK-Unclassified --------------------AYIDDEPKAPDVV--------------------------- TRRAP_Hsap_TRRAP -----------------------------------------A-IKIISII-VKN---DD- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------AERFLGV-ITY---FES- CG2905_Dmel_TRRAP -----------------------------------------A-VLIIFTL-MES---DD- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------GLKLATAI-LQNWRKCD- ATR_Mmus_ATR ------------------------------------------QPKLLGI-LAF---FNM- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ----------------------------------------------------------YA B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -----------------------------------------N-IK-------KG---EK- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR TLPNSTKDMDNWYVCHLCDIEKTGNPFVRINPNRPEAAGKSE-------IFRI---LHS- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------QPKLLGI-LAF---FNM- DNAPK_Hsap_DNAPK ------------------------------------------GLKLATTI-LQHWKKCD- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -----------------------------------------A-IKIISII-VKN---DD- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------IKEFLGS-MNF---FTM- DNAPK_Ddis_DNAPK ------------------------------------------GFKDIIES-IVLFLNSI- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -----------------------------------------T-LSMVSII-RKQ---LP- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----------------------------------------S-IRICATM-VKH---DK- CC1G_00839_Ccin_ATM ----------------------------------------------------------DL CC1G_08126_Ccin_ATR ------------------------------------------ATQMLGI-MSK---IID- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -----------------------------------------AILEIIDDL--I---TLE- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -----------------------------------------G-ISLFHFL-LEE---RE- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------RQHFVRL-LNN---IDR- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP YSQD-KLIDLDDEENKDEDERKIWDRDMF------------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM WLTSQT----------------------QHVSPKAAQLCSWIATSLGNSRFDSWVMRDAC CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -------------------------------------------------AFSIVDRISKS B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM VQFLCRYLSVSGRRSSWPFKGTGEEPTPTSILEKLTTDPDVRVRFRVATAIPMLFAVSRT CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP --SWLA----S-----QH-----------SLVSQLRRVWVSEN--FQE------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR --CLSE----------PSFEK--PL----------------------------------- CG2905_Dmel_TRRAP --QWIP----T-----RQ-----------DIVDALKNCWQN----YLS------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK --SWWA----PD-----S--APESKTTVLSLLAKMLQIDSALS--FDTNHSSFSEIFTTY ATR_Mmus_ATR --QLLS----------SSVGI--ED----------------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP CPEWLI----S-----PN-----------SPIPRIKKLFSETE--FNE------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR --FMISTAIET-----R------------------------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR --NFLS----HPNIDEFSESLLSG------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR --QLLS----------SSVGI--ED----------------------------------- DNAPK_Hsap_DNAPK --SWWA----KD-----S--PLETKMAVLALLAKILQIDSSVS--FNTSHGSFPEVFTTY TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP --AWLA----S-----QH-----------SLVSQLRRVWVSET--FQE------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR --IMTN----------KQKST--QE----------------------------------- DNAPK_Ddis_DNAPK --SEWT----LN-----SNLKLVEKENIIEFTKNLIKIDPIQF--FENKHC-YEFVYNII SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP --NWLP----E-----NR-----------KVLDILIEYWRPLSHMIQS------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -------------------------------------IDFKFA--TDPTHLAFCPVFNQY FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --EWLP----Q-----TP-----------TVFVHLRRIWVSDA--FQE------------ CC1G_00839_Ccin_ATM DNHKLP----S-----L------------------------------------------- CC1G_08126_Ccin_ATR --TLQD----VH----GKKSV--E------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --PTFL----SQ----HAYVT--D------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP --EWIK----D-----KG-----------EVIKHLKAIWLSDS--YHS------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR --KLLR----------S-EDV--QM----------------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ---------------------------------RHR---------------KENMAATNW SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -------------------KEETLYSLGQ--IM--------------------------- CG2905_Dmel_TRRAP ---------------------------------TLS---------------SEDVLCDLW CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ASLLADTKLGLHLKGQAII----------------------------------------- ATR_Mmus_ATR -------------------KKMALTSLMS--LM--------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ---------------------------------RYVVRALTEVKKFQEEIIVKRMTEHKY B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------ILFSLHRIFSHFQPPKLT---------------DGNGQINKS ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -------------------KKMALNSLMS--LM--------------------------- DNAPK_Hsap_DNAPK ISLLADTKLDLHLKGQAVT----------------------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ---------------------------------RHR---------------KENMAATNW smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -------------------KLTMMTSFHR--LL--------------------------- DNAPK_Ddis_DNAPK TNYLCR-SNPLTFKNKVLV----------------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ---------------------------------ASN---------------PLDISNQTL ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK LSMLRDPKKPLAWKTQVLD----------------------------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ---------------------------------RHR---------------HDNQGVSHW CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------AKEQIIRSIGV--FI--------------------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------QLVAVWRSLGL--TPNDG---------------NDKAEITYW AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ---------------------------------LIT---------------KDAVPLSHW ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -------------------QKQALRCIER--LL--------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ---------------------------------------------------------ALW TRRAP_Hsap_TRRAP KEPKLLAYCLLNYCKRNYGDIELLFQLLRAFTGRFLCNMTFLKEYMEEEIPKN------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -----------------------------------------------G------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ---HLIGKILLHYFSNNTNDIELLFQLLRALCFRFIPDVYFLRDFLQHTVAQS------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -----------------------------------------------G------------ DNAPK_Mmus_DNAPK ----LLPFFTSLR--E--------------------GSLENLKHILEKLIVCNFPMKSDE ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP KVPKLILNTFLRYLRLNIYDYDLFIVIASCFNGNFVTDLSFLREYLETEVIPK------- B0261.2_Cele_FRAP -----------------------------------------------S------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -----------------NEGIEFLFIFRTYFT---------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR F--KLVQKCFMN------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ----LLPFFTSLT--G--------------------GSLEELRRVLEQLIVAHFPMQSRE TOR_Dmel_FRAP -----------------------------------------------G------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP KEPKLLAFCLLNYCKRNYGDIELLFQLLRAFTGRFLCNMTFLKEYMEEEIPKN------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -----------------------------------------------G------------ TOR2_Scer_FRAP -----------------------------------------------G------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ----LLPYLLSYPK-H--------------------NNFDLIKQKLNEIVVYDFPLNSKD SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -----------------------------------------------G------------ TRRAP_Ddis_TRRAP RETKIIVKCFLQYCKAHSEETDLYFYMLSVLTLRASMDFNFLRDYYQH------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ----VLYFFANVP--E--------------------KEEKELKSALDLLVANHFPLKSTD FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP EEPKLLVKCLLNYAKQHPSNVELLFQLLRVFSNRYLPNFQFFRTFLEETVAQG------- CC1G_00839_Ccin_ATM -----------------------YNEMKDAFSADVDHHCQVLQKDIETGIDQC------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP -----------------------------------------------G------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -----------------------------------------------V------------ CC1G_00331_Ccin_TRRAP H--SIIQSSFIKAM-KQTPRIDLLFELIAIYSRNLEIDTVKTTTFLYQHVALS------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP QECSMLVNCLLLYCKYHKDDIETLFYLLKVFMFRHVTSFPFLKSYLENEVAKQ------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -----------------------------------------------G------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -----------------------------------------------A------------ GK009_Glam_PIKK-Unclassified NRLKVMYL---------------------------------------------------- TRRAP_Hsap_TRRAP -------------------------------YSIAQKRALFFRFVD-FNDPN--FG---- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -------------------------------FTVNWKRNAFFYFVENFNNSF--LS---- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK FPPDSLKYNNYVDCMKKFLDALELSQSPMLFQLM-------------------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -------------------------------VPLQWRRELFLRIMQKFDTDPQTAG---- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK FPPGTPRFNNYVDCMKKFLDALELSQSPMLLELM-------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -------------------------------YSIAQKRALFFRFVE-FNDPN--FG---- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK LTVKSPIYNEYITCIERLLETFELTKNPLVIDTL-------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK LDAGSPRYNDYIMALNKILTSLVMSGSLMLLKLI-------------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------------------------YSVEQKRHIFFKFVELFHDKS--FP---- CC1G_00839_Ccin_ATM -------------------------------FGDIVGFHVVVYFFEH--DNPNE-AAMVG CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -------------------------------EDIIFRRNVLMRFLTWFNDSS--VP---- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -------------------------------YTIEQKRAVFFKFVEIFSLSD--YL---- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ----------DELKAKV--------------------------------------LQHIL SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------------ELAQVSG--LEMRKWVDELFII---------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ----------EELKAKI--------------------------------------ITAVI CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------------ELAQVSG--LEMRKWVDELFII---------------------- DNAPK_Mmus_DNAPK ----------TDILCRE--------------------------------------QRHIM ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ----------TSMQ-----------------------------------HV--KALQYLV B0261.2_Cele_FRAP ----------------EIAVIGG--AEIVKNLKPLFEK---------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ----------TEVLCRE--------------------------------------QQHVM TOR_Dmel_FRAP ----------------DLAEVNGGSDEMELWADDLLSI---------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ----------DELKAKV--------------------------------------LQHIL smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ----------------ELSVVGG--EDMKIYLKDLFPL---------------------- TOR2_Scer_FRAP ----------------ELSVVGG--KEMTRYLKELMPL---------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ----------LHVL-KE--------------------------------------TDHTH SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------------ELSVVGG--EEMVQHIDSLLPL---------------------- TRRAP_Ddis_TRRAP ----------------DLAPSST--IEQKKKIIQTFLIFFKDQTIPSDNKV--QAIQNLI ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ----------ISILCRD--------------------------------------EKHSY FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----------QELKAKA--------------------------------------LQYVI CC1G_00839_Ccin_ATM GLATLLGREEDKLR-----------------------------------SDFSAHADAII CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----------------ELACVAG--EDAMPHVQELMQI---------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ----------------DLALIAP--RNAFVDIVRVFSA---------------------- CC1G_00331_Ccin_TRRAP ----------LDTKGYF--------------------------------------IRYVV AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ----------QELKAKI--------------------------------------LQYIL ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------------ELARVAG--CAIRPHIKDLMPL---------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------------ELFTIGS--TSMVHCLAEVIPL---------------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP NPAFLYSFEKGEGEQ-LLG-----------------PPNPEGDN---------PESITS- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ---------------RFVGSQHVT------------------QF---------RFKIIA- CG2905_Dmel_TRRAP IPCFAVSFDKGEGNK-LIGAPP----------------TPYQED---------EKNIVS- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK EELFQTTFKR-------------------------------------------------- ATR_Mmus_ATR ---------------KLMGPKHVS------------------SV---------RVKMMT- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP IPTLHWAFERYDTDE-IVG----------------TAPIDDSDSSMDVDPAGSSDNLVA- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ---------------------SLT------------------EL---------RST---- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ---------------KLMGPKHVS------------------SV---------RVKMMT- DNAPK_Hsap_DNAPK EELFQSSFRR-------------------------------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP NPAFLYSFEKGEGEQ-LLG-----------------PPNPEGDN---------PESITS- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ---------------GLMGQ-SVD------------------LF---------RPKIMA- DNAPK_Ddis_DNAPK INYINLSIER-------------------------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP TPILTNYFHQTDRNS-SSG----------------GGII--------------EDSLFI- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK EDKIQGALSS-------------------------------------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP IPMFAASFDKGEGDS-LIGGPPNPGQDSPDNPLIGGPPNPGQDS---------PDNLVS- CC1G_00839_Ccin_ATM ASMLRTMGDQDYTDN-GKI----------------I------------------------ CC1G_08126_Ccin_ATR ---------------SLVGP-PIH------------------SL---------SSQIMA- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP TPTLLVQANRSPTSDRLIN----L------------------DF---------ISQLHR- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP IPVFTFSFEEGERDE-LLGGPP----------------DPERDS---------DTNIIS- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ---------------EMIGS-HLS------------------AF---------IPKIMA- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified QVIIY--------------------------------------------------GIHTP TRRAP_Hsap_TRRAP ----------------------------------VFITKVL--DPEK------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ----------------------------------MLSFVHTLQEPRL------------- CG2905_Dmel_TRRAP ----------------------------------VFINKVF--DPDK------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK --------------------------------------------IAR------------- ATR_Mmus_ATR ----------------------------------TLRTGLRFK-DDF------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -----------------------------------RLTSVI--DSHR------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR --------------------------------------------NDQYFLTREATAESFR TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ----------------------------------TLRTGLRFK-DDF------------- DNAPK_Hsap_DNAPK --------------------------------------------IAR------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ----------------------------------VFITKVL--DPEK------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ----------------------------------FLRLA--IK-TPM------------- DNAPK_Ddis_DNAPK --------------------------------------------SIL------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ----------------------------------QLTKQTL--ETEV------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK --------------------------------------------FAK------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----------------------------------VFISKVI--DPEN------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ----------------------------------IFQTSLS--VAEL------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ----------------------------------IIWSPIT--ENDA------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ----------------------------------VFISKVI--NPDK------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ----------------------------------LLSQP-----QDL------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified VILESLLDYFGIFFYAVSTLVPGFLYTQLAVDMFLTLEEVI--DTDQ------------- TRRAP_Hsap_TRRAP ------QADML--------------------DSL-RIYL--------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------------------------------I------------------------- mei-41_Dmel_ATR ------QRICL--------------------KIW-H------------------------ CG2905_Dmel_TRRAP ------QY--D--------------------DAV-RIAL--------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------------------------------I------------------------- DNAPK_Mmus_DNAPK ------QSPCVTQLNLLESVYTMFRKADLPSNVT-RQAF--------------------- ATR_Mmus_ATR ------PELCC--------------------RAW-D------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------NY-LS--------------------DGM-VIVF--------------------- B0261.2_Cele_FRAP ----------------------------------L------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ILLQNMKQDFF--------------------DTNWYI----------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------PELCC--------------------RAW-D------------------------ DNAPK_Hsap_DNAPK ------RGSCVTQVGLLESVYEMFRKDDPRLSFT-RQSF--------------------- TOR_Dmel_FRAP ----------------------------------L------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------QADML--------------------DSL-RIYL--------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ----------------------------------I------------------------- TOR2_Scer_FRAP ----------------------------------I------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------EEIAI--------------------DAW-F------------------------ DNAPK_Ddis_DNAPK ------STNDIEAKEIFSHCFELFLN---HYDEL-KITL--------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------------------------------I------------------------- TRRAP_Ddis_TRRAP ------KASYD--------------------DTLL------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------RLPSEKQSAAANIPFEIFKQDKRYSKEI-RKAA--------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------PYGTS--------------------DSV-RILL--------------------- CC1G_00839_Ccin_ATM ------------------------------------PALESVTGSDNLQEDSKHVAVFRV CC1G_08126_Ccin_ATR ------AEVTL--------------------ESW-H------------------------ CC1G_00894_Ccin_FRAP ----------------------------------I------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ----------------------------------I------------------------- CC1G_00331_Ccin_TRRAP ------FLGSE--------------------EYF-KIEI--------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------PFGSS--------------------DSV-CILL--------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------QYESL--------------------SVW-L------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------------------------------I------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------------------------------L------------------------- GK009_Glam_PIKK-Unclassified ------NN------------------------SIFTIYW--------------------- TRRAP_Hsap_TRRAP -LQYATL----------------------------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -MDMLQD----------------------------------------------------- mei-41_Dmel_ATR -IFLHVV----------------------------------------------------- CG2905_Dmel_TRRAP -LQLACL----------------------------------------------------- CG6535_Dmel_ATM ----------------------------------------------------YSASFSSQ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -MDMLQD----------------------------------------------------- DNAPK_Mmus_DNAPK -V---------------------------------------------------------- ATR_Mmus_ATR -CFVRCL----------------------------------------------------- ATM_Mmus_ATM ------VFISNLPEIVVELLMTLHETADSADSDASQSATALCDFSGDLDPAPNPPYFPSH C47D12.1_Cele_TRRAP -YQLCTL----------------------------------------------------- B0261.2_Cele_FRAP -THMIND----------------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------LFISNLPEIVVELLMTLHEPANSS---ASQ-STDLCDFSGDLDPAPNPPHFPSH ATR_Hsap_ATR -CFVRCL----------------------------------------------------- DNAPK_Hsap_DNAPK -V---------------------------------------------------------- TOR_Dmel_FRAP -LEMLGD----------------------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -LQYATL----------------------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -IKTFQD----------------------------------------------------- TOR2_Scer_FRAP -INTFQD----------------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -TFIQLL----------------------------------------------------- DNAPK_Ddis_DNAPK -I---------------------------------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -IDTLQD----------------------------------------------------- TRRAP_Ddis_TRRAP -IELLQL----------------------------------------------------- ATMa_Spur_ATM ------WIQSHLHLIVVELLTMLYEPWTE----TS----QSSRFMTPSDPEPDPPFFTSY ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -I---------------------------------------------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -LQFAAL----------------------------------------------------- CC1G_00839_Ccin_ATM LTRYRG------------------------------------------------------ CC1G_08126_Ccin_ATR -EYLVTI----------------------------------------------------- CC1G_00894_Ccin_FRAP -LAKLAD----------------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -NRSANP----------------------------------------------------- CC1G_00331_Ccin_TRRAP -LNLTTV----------------------------------------------------- AqueK043_Aque_ATM ------SLKHSLPLLVVELLTRLYVPANS----DS----ALAQYSNVCDPEPIPPHHSLS AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -LQFSSL----------------------------------------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -SFVKRL----------------------------------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -VDALRD----------------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -ITCIKE----------------------------------------------------- GK009_Glam_PIKK-Unclassified -L---GY----------------------------------------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ALH-------------------------------DFFLYCEVADAV---YDAARKNETIV CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM VIQATFAYISNCHKT-KFKSILEILSKIPDSYQKILLAICEQAAETNNVFKKHRILKIYH C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM VIKATFAYISNCHKT-KLKSILEILSKSPDSYQKILLAICEQAAETNNVYKKHRILKIYH ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM MIKATLDHLTTCHAGGRSLTLISLLAKTHDSIQKVLLELHLRMWRCRQPYERRRLLLGYR ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM AISTTLQYLPSCFSS-STDSFISVLAKQKEALQTIALHLNLRIFSTHRVFERKRLLISYS AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM TQCSFFVR-------DIWFFVVRLLIHTKFIRVQMAA------LT--------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM LFVSLLLKDIQSGLGGAWAFVLRDVIYTLIHYINK-RS-----SHFTDVSLRSFSLCCDL C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM LFVSLLLKDIKSGLGGAWAFVLRDVIYTLIHYINQ-RP-----SCIMDVSLRSFSLCCDL ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM LFGLLLIKELHTKLGGSWVYVLQNLIYTLVHTIHQ-HRAGEGRSSVMEGSSSLVLPCLDL ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM YFSSLVSRELTSGLHGSLPYMVMDIIYSVGRVMHH-HG-----N---DE--SISLICCDT AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP --------L---V-------EHAPHHIHDN--N-KNRNSKLRR------------LM--T SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP --------SSLLA----------------------------------------------- mei-41_Dmel_ATR --------N---V-------QELGPSLGRI----------V-A------------TL--Q CG2905_Dmel_TRRAP --------L---V-------ERASQHIHDGDANNKRQGNKLRR------------LM--T CG6535_Dmel_ATM -------FLELLLNKHNFRLDDYQNHFGDI----------A-K------------LLSNF CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP --------SSLLA----------------------------------------------- DNAPK_Mmus_DNAPK ----------------------------------------DRS------------LL--T ATR_Mmus_ATR --------D---H-------AYLGPLLSHV----------I-V------------AL--L ATM_Mmus_ATM LSRVCHTAVTQC-------KDALESHLHVI----------V-G------------TL--I C47D12.1_Cele_TRRAP --------F---V-------QNASEHIHN--NNCKKQGGRLRI------------LM--L B0261.2_Cele_FRAP --------SSSLH----------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------ILMTLRQIPLNLDST--Q TEL1_Scer_ATM ----------------------------------------V-E------------KL--F MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM LSQVCQTAVTYC-------KDALENHLHVI----------V-G------------TL--I ATR_Hsap_ATR --------D---H-------ACLGSLLSHV----------I-V------------AL--L DNAPK_Hsap_DNAPK ----------------------------------------DRS------------LL--T TOR_Dmel_FRAP --------AGSPD----------------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP --------L---V-------EHAPHHIHDN--N-KNRNSKLRR------------LM--T smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP --------QSNSF----------------------------------------------- TOR2_Scer_FRAP --------QSNSF----------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR --------K---L-------DSIGPILNQI----------V-F------------SI--L DNAPK_Ddis_DNAPK ----------------------------------------DKF------------CV--P SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP --------QSSTS----------------------------------------------- TRRAP_Ddis_TRRAP --------ETLLV----------------------------------------------- ATMa_Spur_ATM LRHISEAAVVQC-------SEEFSKHIEVI----------L-G------------AV--V ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ----------------------------------------QRV------------CI--P FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --------L---V-------ERAAPHIHDA--ADKKQGTKLRR------------LM--T CC1G_00839_Ccin_ATM --------L---E-------TFTPH-EPN--SPALPTSCI---------------LR--G CC1G_08126_Ccin_ATR --------D---S-------KDLGPHLGST----------C-S------------AF--V CC1G_00894_Ccin_FRAP --------PQT-L----------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K --------HKLPA----------------------------------------------- CC1G_13883_Ccin_PI4K --------DDPRF----------------------------------------------- CC1G_00331_Ccin_TRRAP --------L---V-------QYYSDLLDDV----------KKD------------II--R AqueK043_Aque_ATM LTNVTKAAIEKC-------PEVIGRHCHMI----------I-N------------TL--L AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP --------L---V-------EHAAPHIHDS--NNKKQGAKLRR------------LM--T ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR --------AQVSP-------ANLKTVASQI----------V-V------------AL--M DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------TSAAS----------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP --------ETSKT----------------------------------------------- GK009_Glam_PIKK-Unclassified --------IRLLL-------EH-------------------------------------- TRRAP_Hsap_TRRAP ---------FAWPCLLSKA-----CVD---------------------------PA---- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP --------------KRQVALWTLGQLVASTGYVVEP-------------------YRKYP mei-41_Dmel_ATR PL------LA-------------------------------------------------- CG2905_Dmel_TRRAP ---------FAWPCLLSKS-----SVD---------------------------PT---- CG6535_Dmel_ATM QL------CC-------------------------------------------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP --------------KRQVALWTLGQLVASTGYVVEP-------------------YRKYP DNAPK_Mmus_DNAPK ---------LLWHCDLDTLKEFFSRIVVDAIDVLKSRFTKLNE--FTFDTQITKKM---- ATR_Mmus_ATR PL------IH-------------------------------------------------- ATM_Mmus_ATM PL------VD-------------------------------------------------- C47D12.1_Cele_TRRAP ---------FAWPCLTMYN-----HQD---------------------------PT---- B0261.2_Cele_FRAP --------------KREAALRAIGGICRSTAYVVDP-------------------YRDYP atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ---------SSWISFIE------------------------------------------- TEL1_Scer_ATM PTSYLSPYLF-------------------------------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM PL------VY-------------------------------------------------- ATR_Hsap_ATR PL------IH-------------------------------------------------- DNAPK_Hsap_DNAPK ---------LLWHCSLDALREFFSTIVVDAIDVLKSRFTKLNE--STFDTQITKKM---- TOR_Dmel_FRAP --------------KRGVALWTLGQLISATGRVVTP-------------------YHKYP SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ---------FAWPCLLSKA-----CVD---------------------------PA---- smg-1_Cele_SMG1 -------------------------------------------------------KK--T TOR1_Scer_FRAP --------------KREAALKALGQLAASSGYVIDP-------------------LLDYP TOR2_Scer_FRAP --------------KRDAALTTLGQLAASSGYVVGP-------------------LLDYP TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR PF------VQ-------------------------------------------------- DNAPK_Ddis_DNAPK ---------LISHMKENILVQIFSQHLSSLMSIIQPLQPKYLSDSQERKSSIIEKI---- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP --------------KREVALKTLAQLASSTGYVIKP-------------------FSKYP TRRAP_Ddis_TRRAP --------------KNLS-------------SVLVD-------------------CR--K ATMa_Spur_ATM PL------VG-------------------------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ---------LLRQASRDATVTFYKGHIHDIISVLEARLTKNPV--PAFENQLVSKI---- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ---------FAWPCLIQKN-----CVD---------------------------PT---- CC1G_00839_Ccin_ATM ---------LAWMETVPQA-----CRK---------------------------AT---- CC1G_08126_Ccin_ATR ---------SAWPNLSD-------R----------------------------------- CC1G_00894_Ccin_FRAP --------------KRDAALHALGQVCSSTGYVVQP-------------------LLDHP CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K --------------EV-------------------------------------------- CC1G_13883_Ccin_PI4K --------------SNNMVLAAQ-------TRLAQE-------------------LHRRP CC1G_00331_Ccin_TRRAP ---------CAWAPIQN-------NDD---------------------------VL---- AqueK043_Aque_ATM PL------TQ-------------------------------------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ---------FAWPCLLPKQ-----CVD---------------------------PA---- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR PC------LE-------------------------------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------------KRDVAVRTLGQLVQNTGYVVTP-------------------YTEFP SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP --------------LRLTTTRCFVRIVEATSFVVFP-------------------WFIYH GK009_Glam_PIKK-Unclassified -----------------------------SGETLT------------------------- TRRAP_Hsap_TRRAP ------------------CKYSGHLLLAHIIAKFAIH------KK--IVLQVFHSLLKAH SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP TLLEVLLN-FLK-TEQNQGTRREAIRVLGLL----------------------------- mei-41_Dmel_ATR -----------------------------------DN-E-S--VKQ-------------- CG2905_Dmel_TRRAP ------------------ARYHGHLLLSHIIARLAIH------KK--IVLQVFHSLLKGH CG6535_Dmel_ATM -----------------------------------EAK-EV--REK-------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP TLLEVLLN-FLK-TEQNQGTRREAIRVLGLL----------------------------- DNAPK_Mmus_DNAPK ------------------CYYKMLAVMYSRLLKDDVH------SKEAKINQAFHGSR--- ATR_Mmus_ATR -----------------------------------MQ------PKE-------------- ATM_Mmus_ATM -----------------------------------Y-Q-EV--QEQ-------------- C47D12.1_Cele_TRRAP ------------------MRYTGFFFLANIIERFTIN------RK--IVLQVFHQLMTTY B0261.2_Cele_FRAP SLLDDLLR-ILK-TVMSNTMRREAIKTLGIL----------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR --------------------------------------------------QINYSILR-- TEL1_Scer_ATM -----------------------------------EN-S-S--VSM-------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----------------------------------EQV-EV--QKQ-------------- ATR_Hsap_ATR -----------------------------------IQ------PKE-------------- DNAPK_Hsap_DNAPK ------------------GYYKILDVMYSRLPKDDVH------AKESKINQVFHGSC--- TOR_Dmel_FRAP VLIDILIN-FLK-TEQRRSIRRETIRVLGLL----------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------CKYSGHLLLAHIIAKFAIH------KK--IVLQVFHSLLKAH smg-1_Cele_SMG1 RLMISSWLHSLI-ATACE----------HQIGSDSFS------QR--EWVRLRNTVIHQS TOR1_Scer_FRAP ELLGILVN-ILK-TENSQNIRRQTVTLIGIL----------------------------- TOR2_Scer_FRAP ELLGILIN-ILK-TENNPHIRRGTVRLIGIL----------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -----------------------------------SY-P-----EK-------------- DNAPK_Ddis_DNAPK ------------------CCFHLIEALYQSLPSAII---------KEKINPFFYDKP--- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP MLLDTLLN-AIK-TERIGSIRREVIKVLGIL----------------------------- TRRAP_Ddis_TRRAP ELIKFAWN-HLK-NEDLTCKQSAYILACGFIEAYETP------HK--IVLQVYVPLLRAY ATMa_Spur_ATM -----------------------------------NSHDDV--SKQ-------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------CYFELIEVLYSRLSKDDLN------SKDSALNREYRHGN--- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------TKYHGHLLLAHNIAKFAIH------KR--IVLQVFHSLLKAH CC1G_00839_Ccin_ATM ------------------TYHVIHELFASIEDTPLVN------EK--LRL---------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP QLLPLLGR-IMR-TETSVQTRREVVKVLGIL----------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ELY--------------------------------------------------------- CC1G_00331_Ccin_TRRAP ------------------IRQMAFLLLARFFSVFPSP------PK--FVLRAWTDLLRLP AqueK043_Aque_ATM -----------------------------------LPEP-K--NKP-------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------TKYHGHLLLAHIISKFAIH------KR--IVLQVFHSLLKAH ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -----------------------------------SE-Q-SSTIDA-------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP HLLGLLLR-ILLNGELEWSTRNEVLKVLGVI----------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP DLFTIVFG-ILK-NDTSQEIRLEAAKLITTI----------------------------- GK009_Glam_PIKK-Unclassified QLI----ELIIDGRRISEET----KRVARLLV---------------------------- TRRAP_Hsap_TRRAP AME-ARAIVR-QAMAILTPAV---P----------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP --------------------G--------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ALE-ARSIVK-QALDVLTPAM---P----------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP --------------------G--------------------------------------- DNAPK_Mmus_DNAPK VAE-GNELT-KTLLKLCHDAF---TENMVGESQLLEK--RRLYHCAAYNCAISLISCVFN ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP QQD-TRDQIR-KAIDILTPAL---R----------------------------------- B0261.2_Cele_FRAP --------------------G--------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ITE-GNELT-KTLIKLCYDAF---TENMAGENQLLER--RRLYHCAAYNCAISVICCVFN TOR_Dmel_FRAP --------------------G--------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP AME-ARAIVR-QAMAILTPAV---P----------------------------------- smg-1_Cele_SMG1 VLTWNNECVN-QALTILSTAT--------------------------------------- TOR1_Scer_FRAP --------------------G--------------------------------------- TOR2_Scer_FRAP --------------------G--------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK DGK-GTELT-AAIMKAAHSAK---SEKLTSDDKYVTRSLCTKYHGAAFSALASVIVSTQT SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP --------------------G--------------------------------------- TRRAP_Ddis_TRRAP QPE-SKHLVK-QALDILMPCF--------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK VEK-GNEMS-TALTKAALGAR---NEDCRGETVAVEL--RRQFHCAAFNCSAAIISCVQD FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP AAE-ARSVVR-QALDILTPVL---P----------------------------------- CC1G_00839_Ccin_ATM ----------------VNALCLWIA----------------------------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP --------------------G--------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP HSE-GRASVRYEALSILAPSL---P----------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP AIE-ARAIVR-QALDILTPVV---P----------------------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------------------G--------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP --------------------G--------------------------------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------ALD----------------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------ALD----------------------------------------------- DNAPK_Mmus_DNAPK ELKFYQGFLFNEKPEKNLFIFENLIDLKRCYTFPIEVEVPMERKKKYIEIRKEARDAA-- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ----------AID----------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ELKFYQGFLFSEKPEKNLLIFENLIDLKRRYNFPVEVEVPMERKKKYIEIRKEAREAA-- TOR_Dmel_FRAP ----------AMD----------------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ----------KWS----------------------------------------------- TOR1_Scer_FRAP ----------AID----------------------------------------------- TOR2_Scer_FRAP ----------ALD----------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK KENFFHVFFFKENKDKNEYLWENIIDTDQVFNFQPETNFLVSYSTPQ------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------SLD----------------------------------------------- TRRAP_Ddis_TRRAP ----------K------------------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK NIKFYNAFLFSENHAKGQFLLDNLVDPKKEYGFAIEMDAPVERKKRFVAIRTQARETNTP FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----------ALD----------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------ALD----------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------AID----------------------------------------------- GK009_Glam_PIKK-Unclassified ----------S------------------------------------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK --NGASGS-PHYMSSLSYLTDSSLSEEMSQFDFSTGVQSYSYSSQDRKPTTGHFQRREHQ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK --NGDSDG-PSYMSSLSYLADSTLSEEMSQFDFSTGVQSYSYSSQDPRPATGRFRRREQR TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK --SLF-ANDLRYLS-SQYLVDSSLSQDFIAKNFLEGDNNST--TNNNNGDDGIIMQGQSQ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK EESGYVSGPAHYL-SSQYLSDSSLSEDVNQFDFSSSVRHFGSSMESQRDGGSQGSQGSQR FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK DSM------------TQDD-IMELEMDELNQHECMAPMIALIKHMQRN-VIAPK-----G ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK DPT------------VHDD-VLELEMDELNRHECMAPLTALVKHMHRS-LGPPQ-----G TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK SGDN------------ENQISNDIEIDQVNSNPSMIAMLKIIDFYQKKFVVTPPSSILFG SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK PGSMASRQDSKPVFSPGGE-YLEMEEDALNQHECMAAMTGVLKHMTNN-KINPD-----I FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ----A----------RMEDG--------H------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----PY----------K------------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ----L----------RMEDG--------N------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----PY----------K------------------------------------------- DNAPK_Mmus_DNAPK E--------------EGSI---------P------------------------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ----T----------RMEDG--------H------------------------------- B0261.2_Cele_FRAP ----PY----------T------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ----SNIWRILTDISRIENNDILIEKVWN------------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK E--------------EDSV---------P------------------------------- TOR_Dmel_FRAP ----PY----------K------------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ----A----------RMEDG--------H------------------------------- smg-1_Cele_SMG1 ----EL----------TSDI---------------------------------------- TOR1_Scer_FRAP ----PY----------R------------------------------------------- TOR2_Scer_FRAP ----PY----------K------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK QQSQQ----------PKPT---------V------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----PY----------K------------------------------------------- TRRAP_Ddis_TRRAP ----TR----------LPGG--------D------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK T--------------KATK---------A------------------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----Q----------RMEDG--------N------------------------------- CC1G_00839_Ccin_ATM ----Y----------RHQDF--------NDVILLYAVLHGASALLRQEVLARAAQSILQW CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----PY----------R------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ----K----------SDGD---------D------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ----V----------RMEDA--------N------------------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----PH----------V------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----PI----------F------------------------------------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP --------------------------Q---MLTHWTR--------KI------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ---------------------------------------VNDLYEFI------------- CG2905_Dmel_TRRAP --------------------------T---MLTHWTK--------KI------------- CG6535_Dmel_ATM ---------------------------------------TMSIVMYI------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK --------------------------K---DLPPWMKFLHDKLGN--------------- ATR_Mmus_ATR ---------------------------------------TAAIFHYL------------- ATM_Mmus_ATM ---------------------------------------VLDLLKYL------------- C47D12.1_Cele_TRRAP --------------------------L---QILSHVK--------KI------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR --------------------------R---LS----Y--------DM------------- TEL1_Scer_ATM ---------------------------------------RYQYPLHI------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ---------------------------------------VLDLLKYL------------- ATR_Hsap_ATR ---------------------------------------TAAIFHYL------------- DNAPK_Hsap_DNAPK --------------------------R---DLPSWMKFLHGKLGN--------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP --------------------------Q---MLTHWTR--------KI------------- smg-1_Cele_SMG1 ----------------------------HRDIADKTK--------KA------------- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ---------------------------------------SLLIFDYL------------- DNAPK_Ddis_DNAPK --------------------------G---DMPKWMFEIYQKLQ---------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP --------------------------PKNSTWVKWTK--------KI------------- ATMa_Spur_ATM ---------------------------------------ALSLVEFL------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK --------------------------E---EMPQWMSGLQKKLSS--------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --------------------------A---MLTHWTK--------KI------------- CC1G_00839_Ccin_ATM TFRCYHKFKAADSRLSRILIRLSSICH---DYAAQVH--------DP------------- CC1G_08126_Ccin_ATR --------------------------------------ARKIIVESL------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------C--------LPLWCPGTDTAHTNP CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --------------------------P---EFPQWAKATRRLLTE--------------- AqueK043_Aque_ATM ---------------------------------------AIALLDYI------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP --------------------------A---TLVHWTK--------KI------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ---------------------------------------AVQILEEL------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -----------------IV------------------------------EEGH-T--VP- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -----------------IL------------------------------RNAS-M--LG- CG2905_Dmel_TRRAP -----------------IV------------------------------EEGH-A--MQ- CG6535_Dmel_ATM -----------------LE------------------------------SKKG-HINLN- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK --------------------------------------------------AS-----VSL ATR_Mmus_ATR -----------------II------------------------------ENRD-A--VQ- ATM_Mmus_ATM -----------------VI------------------------------DNKD-NKNLS- C47D12.1_Cele_TRRAP -----------------LI------------------------------EECH-N--LQ- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -----------------VIDKISTDAMIKRVFWLIPLEVEKRIDLKFEISKSR-Q--IE- TEL1_Scer_ATM -----------------PL------------------------------ALGA-T--LV- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----------------VI------------------------------DNKD-NENLY- ATR_Hsap_ATR -----------------II------------------------------ENRD-A--VQ- DNAPK_Hsap_DNAPK --------------------------------------------------PI-----VPL TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -----------------IV------------------------------EEGH-T--VP- smg-1_Cele_SMG1 -----------------KW------------------------------KEAT-T--IW- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -----------------II------------------------------KNRT-I--LK- DNAPK_Ddis_DNAPK --------------------------------------------------QG-----VHP SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -----------------IV------------------------------EEGH-T--TA- ATMa_Spur_ATM -----------------VV------------------------------ENHG---KLK- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK --------------------------------------------------QS-----TEH FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----------------IV------------------------------EEGY-T--IA- CC1G_00839_Ccin_ATM -----------------AA------------------------------VRLGED--LL- CC1G_08126_Ccin_ATR -----------------QL------------------------------AFGR-L--KD- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K SHPHHRIVRIPPGESVVL------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --------------------------------------------------EG-----AG- AqueK043_Aque_ATM ------------------I------------------------------ENGQ-IRALQ- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -----------------IV------------------------------EEGQ-T--MA- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -----------------IL------------------------------KNRR-L--LG- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -QLVHILHLIVQHF---------------------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -TFITDLYFLDRME---NVSPSIQKCIRRHTAHLDLKGLAEEENQSPPLVDQLRFLQKHI CG2905_Dmel_TRRAP -QLFHILQLIIRHY---------------------------------------------- CG6535_Dmel_ATM -SF---LEETTDCEF---LKPLRE-------------DCKSSQPN-ID-RADVANYLRSF CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK NIRLFLAKLVINTE---------------------------------------------- ATR_Mmus_ATR -DFLHEIYFLPDHPELEKIKAVLQ-------------EYRKETSETTDLQTTLQLSMKAI ATM_Mmus_ATM -VTIKLLDPFPDHVIFKDLRLTQQ-------------KIKYSGGP-FSLLEEINHFLSVS C47D12.1_Cele_TRRAP -HVQHVFQMVVRNY---------------------------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -DVLEFIRMFPQY----------------------------------------------- TEL1_Scer_ATM -QTQFAHEKNNTHEFKLLFLSVITDL-EK------------TSTYIGKLRCARELKYLFV MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -ITIKLLDPFPDHVVFKDLRITQQ-------------KIKYSRGP-FSLLEEINHFLSVS ATR_Hsap_ATR -DFLHEIYFLPDHPELKKIKAVLQ-------------EYRKETSESTDLQTTLQLSMKAI DNAPK_Hsap_DNAPK NIRLFLAKLVINTE---------------------------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -QLVHILHLIVQHF---------------------------------------------- smg-1_Cele_SMG1 -ESGDCNTYIRQSM---------------------------------------------- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -PYFKTIPFLPKEY--TVLKPYIQ-------------ELES---SSANLTTQIKQLMELF DNAPK_Ddis_DNAPK NIVIFMIKIIINRP---------------------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -QLVHIIQLIVRHP---------------------------------------------- ATMa_Spur_ATM -EALLDTNPLPDKAELKKARKVLE-------------KIKNKQED-ANLLAEINHFLMRG ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK NIKLFIVRLVINAQ---------------------------------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -QLVHMLQLLVRHY---------------------------------------------- CC1G_00839_Ccin_ATM -QWFDAQMVKLSTV---------------------------------------------- CC1G_08126_Ccin_ATR -DLIHYLDDLPDLSIIDDLKPLHF----------HLSQLRH----PLPPRDSLEKLLDRC CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -QAFAIYHLIVKQP---------------------------------------------- AqueK043_Aque_ATM -DHLILLDPLPGEGPVKEASSRLD-------------IIKASVNE-QSLSREINRFCMVH AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -QLIHILQLLCRHY---------------------------------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -DQIKELPLLPSLEPLAAVNAVLN-------------EVRG---F-LSLRDQLLRAGEGL DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified -------------------------------------IYRKE------------------ TRRAP_Hsap_TRRAP ----------------KVYYPVRHHLVQHMVS-AMQRLGFTP---------SV-TI---E SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -TDECLQVRVYALQHLGDLFG---RRRPKLNS---------------------------- CG2905_Dmel_TRRAP ----------------KVYFPVRHQLVQHLIN-YMQRLGFPP---------TA-SI---E CG6535_Dmel_ATM LLS----PTPERLRDLRTYIA---EHKDKV------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ----------------EVFRPYAKHWLSP-----LLQLAVCE---------NN-RE---G ATR_Mmus_ATR -QHENVDVRIHALTSLKETLY---KNQEKLIK---------------------------- ATM_Mmus_ATM AYNPLPLTRLEGLKDLRRQLE---QHKDQMLD---------------------------- C47D12.1_Cele_TRRAP ----------------RVYYHVRLELLTPLLN-GVQRALVMP---------NS-VLENWQ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------PSVQ-------------------------------- TEL1_Scer_ATM -LYENVLVKSSTLN----FII---IRLSKFLI---------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM VYDALPLTRLEGLKDLRRQLE---LHKDQMVD---------------------------- ATR_Hsap_ATR -QHENVDVRIHALTSLKETLY---KNQEKLIK---------------------------- DNAPK_Hsap_DNAPK ----------------EVFRPYAKHWLSP-----LLQLAASE---------NNGGE---G TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ----------------KVYYPVRHHLVQHMVS-AMQRLGFTP---------SV-TI---E smg-1_Cele_SMG1 ----------------STVYQMSQERQQKTI----------------------------- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -SNESIEVKLMSTNKLKELLS---ANKSIIHE---------------------------- DNAPK_Ddis_DNAPK ----------------QYFERFHELWIPI-----LMDYVVSE---------GNGGN---G SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ----------------QLFYPSRSQFVPHIIL-LLPKIALGS---------NL-TA---E ATMa_Spur_ATM GQH-CKNHTLEGLNSLHHELA---SRKAELAM---------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ----------------DVFQPYARFWLSP-----LMQFLAGG---------QQ--G---G FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----------------KVYYPVRHHLIQTMVY-SIQRLGNTP---------NA-TL---E CC1G_00839_Ccin_ATM ----------------PVLLDVI-CKAMPAWAHR-------PSAALATVQKAV-TVEHL- CC1G_08126_Ccin_ATR -SSSNLTIATLALEELKRFMQ---TGDPALLH---------------------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ----------------DLFYPVRSLFVPHMTN-SLNKLGMSP---------SS-TT---E AqueK043_Aque_ATM SGNSIASDSVQGLKSLLHCLK---SFHSEL------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ----------------KVYYPVRQHLVQHMVS-SMQRLGLTS---------NA-TL---E ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -NHESLSLRLVTATELLKLLS---SKRNDITA---------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified -------------------NEMRH------------------------------------ TRRAP_Hsap_TRRAP QRRLAVDLSEVVIKWELQRIKDQQPD-SDMDPNSS-G---EGVNSVS------SSIKRGL SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ---------------HKVNIGMIDQS--RDASAVSLS----------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP HKKLAVDLAEVIIKWELHRIKDDRET--KTDGT-E-E---ELIQES--------SVKRSG CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ---------------HKVNIGMIDQS--RDASAVSLS----------------------- DNAPK_Mmus_DNAPK IHYMMVEIVATILSWTGLATPTGVP--KDE------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP TRRHAVEICEMVIKWELFRTLKTDHIISDEEALEV-DKQLDKLRT--------------- B0261.2_Cele_FRAP ---------------HKVFTGSVQS---STAISTALS----------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK IHYMVVEIVATILSWTGLATPTGVP--KDE------------------------------ TOR_Dmel_FRAP ---------------HKMNKGLIDSQ--KDNVLIAYS----------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP QRRLAVDLSEVVIKWELQRIKDQQPD-SDMDPNSS-G---EGVNSV--------SIKRGL smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ---------------QKEREVT-STT---------------------------------- TOR2_Scer_FRAP ---------------HREIEVT-SNS---------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK LHYFVRDVCFILLKWPNIYKSQDGG--GGT------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ---------------HKMNELG-KRR--E------------------------------- TRRAP_Ddis_TRRAP NKKLSIDIADTIIIWEKMRMSNLQQS--IKTSSSSLP----------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK INYMVLDIMLVMLDWSTLAVPEDDE--ERS------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP HRKLVVELVEVIIKWEVQRIREDEGT--A-EPATP-V---EEPPVVAAAPAAPAGVKRSA CC1G_00839_Ccin_ATM -------------------------------------SAIL------------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ---------------RKSRPDE-DVA--------SNA----------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP SRHLSLDILQTVFNWEEQAARQAQD--AGE-NKGG-I----------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP QRRLAVDLTEVIIKWEFQRAKEAQEM--DGEPMEI-M---KDTASTA--VTSGLGLKRSG ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ---------------NKRNELRLHP---SDGNRSSLS----------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ---------------YQNGKPDL--S--ALVPPTNLT---CKCQSTDVFSLDYIMDESNI GK009_Glam_PIKK-Unclassified ----------------TQLYSSVDSQ---------------------------------- TRRAP_Hsap_TRRAP SVDSAQEVKR----------------------------------------FRT-ATGAIS SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------ESKSSQDSSDYSTSEMLV--------------------NMG-NL---------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -IDLVE------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------ESKSSQDSSDYSTSEMLV--------------------NMG-NL---------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------ASSTDR B0261.2_Cele_FRAP ------LPISETDSKDPRQDIIHW--------------------FNYEKC---------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------DGKVD-ESQDIS--TAEL--------------------LVNMGN---------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP SVDSAQEVKR----------------------------------------FRA-ATGAIS smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------D--ISTEQNAPPIDIALL--------------------MQGMSP---------- TOR2_Scer_FRAP ------K--SSVEQNAPSIDIALL--------------------MQGVSP---------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------DPKANDDKNNNMTNEV-I--------------------TI--SP---------- TRRAP_Ddis_TRRAP ------TTTTTTTSSNKPTDSSSL---------------------PP--NTPI-AEGSIT ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP STDLLPDPKR----------------------------------------VRH-TSSGST CC1G_00839_Ccin_ATM -----------------------------------------------------------R CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------ETSVA-AVNQV----PIN--------------------PHPTSS---------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP SDGTA----------------------------------------------GSGNGGGGG ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------ETVHG-QTNDESLMEAWP--------------------TGGISA---------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP WVCHKGEGGAAQEASIKSHGKAVVSPITGHVVENVYIMKLDSGSEVSANV---------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP AVFGRSQS---LPGAD-------------------------------------------- SMG1_Hsap_SMG1 -----------------------PQDFSDVISFILY-GNS------------------HR FRAP_Hsap_FRAP -------------PLDEFYP---------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ---TRKK----------------------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 -----------------------PGMASRRVSVWQQ-RISQYSAVRDNVFRDFFDR-VQK FRAP_Mmus_FRAP -------------PLDEFYP---------------------------------------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP FDFEEAHNKRDMP----------------------------------------------- B0261.2_Cele_FRAP -------------TLEEFYP---------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -------------FAD-------------------------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP -------------ALDEYYP---------------------------------------- SMG1_Mmus_SMG1 -----------------------PQDFSDVISFILY-GNS------------------HR TRRAP_Mmus_TRRAP AVFGRSQS---LPGAD-------------------------------------------- smg-1_Cele_SMG1 -----------------TSTSFGAEEFIIITNFLLKQA----------------TPTTFK TOR1_Scer_FRAP -------------SNDEYYT---------------------------------------- TOR2_Scer_FRAP -------------SNDEYYP---------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 -----------------------GQIFKKIFDWIMG-IGK------------------DQ Tor_Ddis_FRAP -------------SNEDYYP---------------------------------------- TRRAP_Ddis_TRRAP TPSQGGVA---TPNVSDSTPTPG------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP V----------RS-IT-------------------------------------------- CC1G_00839_Ccin_ATM DGHISSNKFRVVR----------------------------------------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP -------------SSDDYFQ---------------------------------------- CC1G_06302_Ccin_PI3K ----------------------------PSAP---Q-ISATFVNDPSL--WGVVDP---- CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -----------------ETY---------------------------------------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP AELKRQRS---QA-QV-------------------------------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------------ATEDYYS---------------------------------------- SMG1_Smoe_SMG1 -----------------------PPQVVCILN---Y-ISQRPQSLPAGWQQRLVFN---- GK008_Glam_FRAP -------------SDFELTL---------------------------------------- GK009_Glam_PIKK-Unclassified --------------LHDVDDP--------------------------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 TGKDNW----LERLF-YS-----------------------------------CQR---- FRAP_Hsap_FRAP -----------------A--VSMVALMRIFRDQSLSHHH------------------TM- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 PEQDSLIHC-LRELFVRS-----------------------------------CQV---- FRAP_Mmus_FRAP -----------------A--VSMVALMRIFRDQSLSHHH------------------TM- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP -----------------A--ITIANLMLMMQDEDS-QSY------------------AE- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP -----------------A--VAIAALMRILRDPTLSTRH------------------TS- SMG1_Mmus_SMG1 TGKDNW----LERLF-YS-----------------------------------CQR---- TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 KGQNSWMDEVLET-FTQG-----------------------------------CRT---- TOR1_Scer_FRAP -----------------T--VVIHCLLKILKDPSLSSYH------------------TA- TOR2_Scer_FRAP -----------------T--VVIHNLMKILNDPSLSIHH------------------TA- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 PSFDSLTKY-LIDLF-DS--FNVISILFNEQNK-ILSQQYLAAQSTMITPPLSLHQ---- Tor_Ddis_FRAP -----------------T--VALTALMKILRDPSLSSHH------------------TS- TRRAP_Ddis_TRRAP ----------------IH-----------------------------------HGA---- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP -----------------T--VVITSLLAILKDQSLSSHH------------------HT- CC1G_06302_Ccin_PI3K -----------------------------------------------------DITNENP CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ----------------------LIELLTLFGDKGVAIQH------------------SKA CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -----------------TVKVAINALMRTLRDPSSSIYH------------------QS- SMG1_Smoe_SMG1 -----------------------------------------------------CLKTKSA GK008_Glam_FRAP -----------------N--VIMSTLYSILSESTLDMYH------------------YD- GK009_Glam_PIKK-Unclassified --------------------AAVLALLELLVDAS-------------------------- TRRAP_Hsap_TRRAP -------------S----LLAK--PID-KQ---HTDTVVNFLIRVACQ-VND-NT---N- SMG1_Hsap_SMG1 --------LDKRDQ-STI-----------PRNLLKTDAVLWQ-WAIWEAAQF--TVLSKL FRAP_Hsap_FRAP -------------------------------------VVQAITFIF-----------KSL mei-41_Dmel_ATR ---------------------T--ILS-EL---PLEPMLEQIVNVLMAGC-Q-HD----- CG2905_Dmel_TRRAP --------------------------------------SFDIIR---------------- CG6535_Dmel_ATM -----------------------------Q---EHEKLLFGVINKLIQMT-RD-AHN--- CG4549_Dmel_SMG1 --------APQDERQMNL-----------SQCTKRCQRLAIA-WLQFEAARY--CVDQRL FRAP_Mmus_FRAP -------------------------------------VVQAITFIF-----------KSL DNAPK_Mmus_DNAPK -----------------------------VL---ANRLLRFLMKH-----VF-HP---K- ATR_Mmus_ATR ---------------------Y--ATD-SE---TVEPVISQLVTVILKGC-Q-DA----- ATM_Mmus_ATM ---------------------LLRASQ-DN---PQDGIVVKLVVSLLQLS-KM-AVNQT- C47D12.1_Cele_TRRAP ------------------DAQR--TII-KE---HADVIVNMLVRFCMT-FHQ-NS----- B0261.2_Cele_FRAP -------------------------------------IAQAIVTIF-----------RSL atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -------------NLASKIERK--TVY-KE---ELPKLIGSLSRILPQ-CHS-KR---E- TEL1_Scer_ATM ---------------------D--TQI-HD---EVITIFSSLLNL----A-D-KN----- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ---------------------IMRASQ-DN---PQDGIMVKLVVNLLQLS-KM-AINHT- ATR_Hsap_ATR ---------------------Y--ATD-SE---TVEPIISQLVTVLLKGC-Q-DA----- DNAPK_Hsap_DNAPK -----------------------------VL---ANRLLNFLMKH-----VF-HP---K- TOR_Dmel_FRAP -------------------------------------VVQAVTFIF-----------QSL SMG1_Mmus_SMG1 --------LDKRDQ-STI-----------PRNLLKTDAVLWQ-WAIWEAAQF--TVLSKL TRRAP_Mmus_TRRAP -------------S----LLAK--PID-KQ---HTDTVVNFLIRVACQ-VND-NT---N- smg-1_Cele_SMG1 --------LEKPDSY--V---------------PETFIEKWD-WIINQTANF--CIVNKM TOR1_Scer_FRAP -------------------------------------VIQAIMHIF-----------QTL TOR2_Scer_FRAP -------------------------------------AIQAIMHIF-----------QNL TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ---------------------M---IQ-LD---SDPILINDLVKSLLIGC-R-DP----- DNAPK_Ddis_DNAPK -----------------------------TLEKHLSKFVNHLMKN-----TY-CT---D- SMG1_Ddis_SMG1 --------I--DDR-RKF-----------ETLISKSDELIWF-WTVWECSKF--CIANRL Tor_Ddis_FRAP -------------------------------------VIQAVMYIF-----------KSL TRRAP_Ddis_TRRAP --------TNIDDE-------------------YRPPLSAIE-HISLFLIRM-ASNWYHI ATMa_Spur_ATM ---------------------LVSMCA-ES---ASDSVLPQLICELVSLC-GSNHSNQD- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -----------------------------PL---VAQD---------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------S----EASK--PIE-KV---YSDAVVNFLIRLACQ-VND-SS---S- CC1G_00839_Ccin_ATM ------------------RLAE--EPF-HN---EIQFPSKAFWRLKES-LPP-TD----- CC1G_08126_Ccin_ATR ---------------------E--LLE-DD---MFDPMIGRLISTVYSAAAR-DG---D- CC1G_00894_Ccin_FRAP -------------------------------------VIEAIMSIF-----------KTQ CC1G_06302_Ccin_PI3K V-----------------EDKH--RRLVRSHRSSPYDRELKPNAKIRDELTH--ILNYSP CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K QNMELKIDDMVEQLASLLLPVD--ALLTHADFNPHEDASKEIVTLF-----------RNT CC1G_00331_Ccin_TRRAP -------------------WRT--PL---S---LRENMVSYLMRLATI-AHD-QP---T- AqueK043_Aque_ATM ----------------------QI--N-NP---DTSNLILELIHTLLNTA-RH-SPD--- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -------------A----DPTW--PLD-KQ---HADSIINFLIRLACQ-VND-TQ---VP ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ---------------------L--VLRETP---ADADAVSSLVTRLLRGC-S-EESRTS- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------------------------------------VVKSLMYIC-------------- SMG1_Smoe_SMG1 DDKKQGDGLDRKED-FSVVEDA--ARFDLVESWCCSSNMAAAWFIIQELARH--CITVRF GK008_Glam_FRAP -------------------------------------AVVVFRTII-----------QTE GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ---TAG-S---------------------------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -GLK-------------------------------------------------------- mei-41_Dmel_ATR -----D-S---------------------------------------------------- CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM -------K---------------------------------------------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -GLK-------------------------------------------------------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR -----N-S---------------------------------------------------- ATM_Mmus_ATM ----GER----------------------------------------------------- C47D12.1_Cele_TRRAP --GSSS-T---------------------------------------------------- B0261.2_Cele_FRAP -GDM-------------------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -Q---------------------------------------------------------- TEL1_Scer_ATM -----T-FEIEPSLPNLFCKIFIYLRENKQLSPSFQQAIKLLEHRDLIKIKTWKYFLDAI MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ----GEK----------------------------------------------------- ATR_Hsap_ATR -----N-S---------------------------------------------------- DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP -GIK-------------------------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ---TAG-S---------------------------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -GLK-------------------------------------------------------- TOR2_Scer_FRAP -GLR-------------------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -----Y-L---------------------------------------------------- DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -SLK-------------------------------------------------------- TRRAP_Ddis_TRRAP -NEK-------------------------------------------------------- ATMa_Spur_ATM ----GQAS---------------------------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -TTTVS-S---------------------------------------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ----LT-E---------------------------------------------------- CC1G_00894_Ccin_FRAP -GLK-------------------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K W-FL-------------------------------------------------------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM -------S---------------------------------------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP GNATSP-N---------------------------------------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ----AG-Q---------------------------------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP CTAI-------------------------------------------------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP --------------------------------------PGEVLSRRCVNL---------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------------------------------------------CVQF---------- mei-41_Dmel_ATR --------------------------------------QLQMASAKCLGE---------- CG2905_Dmel_TRRAP ---------------------------------------ETTVQGKCVML---------- CG6535_Dmel_ATM --------------------------------------TTSIDSLKCLAQ---------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------------------------------------------CVQF---------- DNAPK_Mmus_DNAPK ----------------------------------------RAVFRHNLEI---------- ATR_Mmus_ATR --------------------------------------QARLLCGECLGE---------- ATM_Mmus_ATM --------------------------------------EVLEAVGRCLGE---------- C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ----------------------------------------------APLY---------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -----------------------------------------NKIIKILQK---------- TEL1_Scer_ATM FGNIVQDDIYENTELLDASDCGVDDVVLVSLLFSYARRPVASKIGCSLSK---------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM --------------------------------------EVLEAVGSCLGE---------- ATR_Hsap_ATR --------------------------------------QARLLCGECLGE---------- DNAPK_Hsap_DNAPK ----------------------------------------RAVFRHNLEI---------- TOR_Dmel_FRAP ----------------------------------------------CVPY---------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP --------------------------------------PGEVLSRRCVNL---------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ----------------------------------------------CVSF---------- TOR2_Scer_FRAP ----------------------------------------------CVSF---------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR --------------------------------------KLSVNFLTCLGE---------- DNAPK_Ddis_DNAPK ----------------------------------------RRILKSNLNI---------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------------------------------------------SIPF---------- TRRAP_Ddis_TRRAP ----------------------------------------------CSEL---------- ATMa_Spur_ATM --------------------------------------ALQKAAGQCLGE---------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------IAMTRSSI---------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --------------------------------------PGEQLSRRCMAL---------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR --------------------------------------SLRLVAYECIGI---------- CC1G_00894_Ccin_FRAP ----------------------------------------------CVTF---------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ----------------------------------------------CVLFDFTHMDNQES CC1G_00331_Ccin_TRRAP --------------------------------------R-GIYVSRALGL---------- AqueK043_Aque_ATM --------------------------------------SC--HVSQCLGE---------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP --------------------------------------PAEQLSKRCVSL---------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR --------------------------------------KFKLACAECLGG---------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------------------------------------------SLPM---------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP --LKTALRPDMWPK-S--ELKLQWFDKLLMTVEQPNQ----------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP --LPQ--------------------------------VMPTFLNVIRVC-----DGAIRE mei-41_Dmel_ATR --LG-AIDASYLP---------------SNYNFAS------------------------- CG2905_Dmel_TRRAP --LKMAMRPEIWPQPF--DIKLNWLDKVLATVETPH------------------------ CG6535_Dmel_ATM --IG-PLKISTVS---------------YYFQTD-------------------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP --LPQ--------------------------------VMPTFLNVIRVC-----DGAIRE DNAPK_Mmus_DNAPK --IKTLV--ECWKE-CL-SIP--------------------------------------- ATR_Mmus_ATR --LG-AIDPGRLD---------------FSTTETQ------------------------- ATM_Mmus_ATM --IG-PLDFSTIA---------------VQHNK--------------------------- C47D12.1_Cele_TRRAP ---SQTLRPSMWGEFV--SFRLTMIEKFLSI-PNDNA----------------------- B0261.2_Cele_FRAP --TEQ--------------------------------VIPRLIEVCRRATESSNRANLRE atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR --LPIICSDLPDHNFIRWDTRFKF-------FCEPRQ----------------------- TEL1_Scer_ATM --AA-AINILK------------------------------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM --VG-PIDFSTIA---------------IQHSK--------------------------- ATR_Hsap_ATR --LG-AIDPGRLD---------------FSTTETQ------------------------- DNAPK_Hsap_DNAPK --IKTLV--ECWKD-CL-SIP--------------------------------------- TOR_Dmel_FRAP --LAQ--------------------------------VLPNLLDNVRTA-----DNNLRE SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP --LKTALRPDMWCK-S--ELKLQWFDKLLMTVEQPNQ----------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP --LDQ--------------------------------IIPTILDVMRTC-----SQSLLE TOR2_Scer_FRAP --LDQ--------------------------------IIPGIILVMRSC-----PPSQLD TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR --LG-AIDPVKLD---------------FSLRNQS------------------------- DNAPK_Ddis_DNAPK --VKSFV--ERWKS-LF-KVD--------------------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP --LPQ--------------------------------IMPPFLHAMNTG-----EPLFRE TRRAP_Ddis_TRRAP --LRQTL--VIWPE-T--NIKFSVFEKPMNT-DQPQ-M---------------------- ATMa_Spur_ATM --IG-SPDLSVIA---------------LKKWGGG------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK --TKTTS----QRK-AK-HPP--------------------------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --LKTALRPDVWPN-S--ELRLNFLDKLFLSVGK-------------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR --LG-ALDPYRFQ---------------LPARRAD------------------------- CC1G_00894_Ccin_FRAP --LPQ--------------------------------IIPAFAAITRTS-----IARLQE CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K TALDW--------------------------------LRPALARIALKT-----PSMVV- CC1G_00331_Ccin_TRRAP --LQNIVGPSGWTD-V--TVGLRFFSRALEQTELS------------------------- AqueK043_Aque_ATM --IG-CIELQSIS---------------AHVVTNG------------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP --IRTALKPDLWPS-I--DVKLSWFGKLLETISQVDPS---------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR --LG-AIDPVKLQ---------------ISLRHRS------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----K--------------------------------VMPDLLLTIRNC-----EDNLRE SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP --VPK--------------------------------IISLILENIQNC-----KVFMQE GK009_Glam_PIKK-Unclassified -------------------------------------------------------HTPCE TRRAP_Hsap_TRRAP ------------------------VN-----------YGNI---C-------TGLEVLSF SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP FLFQQLGMLVSFVKSHIRP---------------------------------YMDEIVTL mei-41_Dmel_ATR -----------------------PQ------------H--L---P-------LNILSDDF CG2905_Dmel_TRRAP ------------------------HN-----------LNNI---C-------TGIDFLTF CG6535_Dmel_ATM -------------------------------------FEAF---EKSNG-----E-PMEA CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP FLFQQLGMLVSFVKSHIRP---------------------------------YMDEIVTL DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR -----------------------GK------------DFTF---V-------TGVEDLSF ATM_Mmus_ATM -------------------------------------DVSY---TKAYGLPED--RELQ- C47D12.1_Cele_TRRAP ------------------------LRNDISSTAYANTIQNA---Q-------HTLDMLCN B0261.2_Cele_FRAP FFLQQLANFVAIIRKHAAP---------------------------------YMPAIFTI atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------LT-----------QAVLEDCA--------------- TEL1_Scer_ATM --------------------------------------HHV---P-------KEYLSKNF MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -------------------------------------DASY---TKALKLFED--KELQ- ATR_Hsap_ATR -----------------------GK------------DFTF---V-------TGVEDSSF DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP FLFQQLAILVAFVKLHIIS---------------------------------YMGDIFKL SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------VN-----------YGNI---C-------TGLEVLNF smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP FYFQQLCSLIIIVRQHIRP---------------------------------HVDSIFQA TOR2_Scer_FRAP FYFQQLGSLISIVKQHIRP---------------------------------HVEKIYGV TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -----------------------TA------------E--K---D-----------KVQI DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP FLFQQLGSLVSIVKQHIRD---------------------------------YLVNVFAL TRRAP_Ddis_TRRAP -----------------IS---------------------------------TCLSMLNL ATMa_Spur_ATM -----------------------EQ------------SASY---STAVKRFSDNNDRISC ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR -----------------------TIV-----------LRNF---T-------DENETYQF CC1G_00894_Ccin_FRAP FHLQQLAILVGIIKQHIRN---------------------------------YTLDVFSL CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -----------------------DAT-----------LLQA---L-------SAAKVLHV AqueK043_Aque_ATM -----------------------GTR-----------GRGP---GGG-YVFKQERDKIV- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------NAAASNST-----------YVNV---C-------TALEILLF ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -----------------------SM------------Q--H---T-----------EEDL DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP FIFCQLADLVAIVRQHIRK---------------------------------YLSSILSL SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP TMLRELILIISSIGHHAHS---------------------------------YVSDIFDI GK009_Glam_PIKK-Unclassified FLWRV------------------------------------------------------- TRRAP_Hsap_TRRAP LLTVLQ----SPAILSSFKPLQRGIAACMT--CGNTKVLRAVHSLLSRLMSIF---P--- SMG1_Hsap_SMG1 -------------------------RTPLG--RAQDT----------------------- FRAP_Hsap_FRAP MREFWVM---NTSIQSTIILLIEQIVVALG--GE---FKLYLPQLIPHMLRVF---M--- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP LTTILS----PDQLVSIIRPVQRGLSLCII--HQNTRIVRLMHMFLTRIMAIF---P--- CG6535_Dmel_ATM F----------------------------------------------------------- CG4549_Dmel_SMG1 -------------------------RTTVG--KPQET----------------------- FRAP_Mmus_FRAP MREFWVM---NTSIQSTIILLIEQIVVALG--GE---FKLYLPQLIPHMLRVF---M--- DNAPK_Mmus_DNAPK ----------------YRLIFEKFSHKDP------------------------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM W----------------------------------------------------------- C47D12.1_Cele_TRRAP IIPVMP----KTSLMTMMRQLQRPLIQCLNNGAQNFKMTRLVTQIVSRLL---------- B0261.2_Cele_FRAP IADAWKE---DISVKMVVIEVLTDMGTAIG--ND---FSKYTGELIPYLLTVL---Q--- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -----------------------GIVEVMT--G-TSK-IEYVDRTMCEIYKFF---N--- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR -------------------------------------SNRYLRLLSTRIIPLF---N--- ATM_Hsap_ATM W----------------------------------------------------------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ----------------YRLIFEKFSGKDP------------------------------- TOR_Dmel_FRAP IKEFWTI---NTPLQNTLINLIEQIAVALG--CE---FRDYLAELIPQILRVL---Q--- SMG1_Mmus_SMG1 -------------------------RTPLG--RAQDT----------------------- TRRAP_Mmus_TRRAP LLTVLQ----SPAILSSFKPLQRGIAACMT--CGNTKVLRAVHSLLSRLMSIF---P--- smg-1_Cele_SMG1 -------------------------KTPLG--KPMQT----------------------- TOR1_Scer_FRAP IKDFSS----VAKLQITLVSVIEAISKALE--GE---FKRLVPLTLTLFLVIL---E--- TOR2_Scer_FRAP IREFFP----IIKLQITIISVIESISKALE--GE---FKRFVPETLTFFLDIL---E--- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ----------------KSIILELLSTKGD------------------------------- SMG1_Ddis_SMG1 -------------------------KSPYG--SAFQT----------------------- Tor_Ddis_FRAP IEKYWNS-----NLLIPIIKLVEEISSALN--DE---FKVYLPNLIPQMLNVL---H--- TRRAP_Ddis_TRRAP IAEYQV----NTFIPNNVVALQQSLLQALN--SDNAKISSLLGSLFKKILAAF---P--- ATMa_Spur_ATM R----------------------------------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ----------------AGVIYESLQDRSP------------------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----------PPILSGSKPLQGGIAACMT--CPSTKVIRSVHALLVKLMSTF---P--- CC1G_00839_Ccin_ATM -----------------------KIQ--VEDIAAFTDLLIAHHG---QIDSLN---P--- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ITELWD----NVTLQLPIVALIEALGKALD--AE---FKPFLPTILPLVLKVF---D--- CC1G_06302_Ccin_PI3K -------------------------SQ--------------------------------- CC1G_04234_Ccin_PI4K ----------NSAERAPYL----------------------------------------- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP VSKEQP----DSWYLSNAVLLEKLVQKGLL--YDDANLQDALYPIFDKLVTLF---P--- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP LINVLP----PNVLLSGFKSLNRGLHFCMT--SNNTKVVRYLHSFLSRLIKMF---T--- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP VLDMILPTSPRSASHSPILHLVERLCVALH--DE---FRMHMPEILPKCIQAL---N--- SMG1_Smoe_SMG1 -------------------------RTHLG--GPTQT----------------------- GK008_Glam_FRAP IEVLWA----NQQLIELILALLEEVSIVLD--LS---LGNYGSQFFLKFVGLFTVLK--- GK009_Glam_PIKK-Unclassified --------------------------------------------LIPLVIHVL---NGLF TRRAP_Hsap_TRRAP -------------------------------------------TEPS-----TSSVA--- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -------------------------------------------H---------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -------------------------------------------PDTQ------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -------------------------------------------H---------------- DNAPK_Mmus_DNAPK --------------------------------------------------------N--- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP --------------------------------------------EK------TNVSV--- B0261.2_Cele_FRAP -------------------------------------------T---------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -------------------------------------------PNEA-----SPEMK--- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR -------------------------------------------ISDSHNSEDEH------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK --------------------------------------------------------N--- TOR_Dmel_FRAP -------------------------------------------H---------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -------------------------------------------TEPS-----TSSVA--- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -------------------------------------------N---------------- TOR2_Scer_FRAP -------------------------------------------N---------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -------------------------------------------------------FK--- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -------------------------------------------T---------------- TRRAP_Ddis_TRRAP -------------------------------------------LPTN-----NTTTTTPV ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK --------------------------------------------------------D--- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------------------------------------TESS-----TSNVA--- CC1G_00839_Ccin_ATM -------------------------------------------EKPS-----LSTIR--- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP -------------------------------------------G---------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -------------------------------------------LPEA-----AP-S---- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -------------------------------------------SELV-----S---G--- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------------------------------------------E---------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -------------------------------------------S---------------- GK009_Glam_PIKK-Unclassified VRSYLSLLITLLPHGANLFDQRGMLQIRGGGTPLAHLLLYIKAY---------------- TRRAP_Hsap_TRRAP -------------------------SKYEEL-------------ECLY-----AAVGKVI SMG1_Hsap_SMG1 ----------------------------------------------FQTIEGIIRSLAAH FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -------------------------HKHEDL-------------DLLY-----TAVSKMI CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ----------------------------------------------FLGFEAIIMRHARL FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK -------------------------S---K-----------------DNSVGIQLLGIVI ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -------------------------NGLDEL-------------EQLN-----QYISRFL B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -------------------------STLDGI-------------KNMY-----A------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK -------------------------S---K-----------------DNSVGIQLLGIVM TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ----------------------------------------------FQTIEGIIRSLAAH TRRAP_Mmus_TRRAP -------------------------SKYEEL-------------ECLY-----AAVGKVI smg-1_Cele_SMG1 ----------------------------------------------FAAFENEIKRLAKE TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -------------------------SKSRQ-----------------IKTTGLVLLSILL SMG1_Ddis_SMG1 ----------------------------------------------FEIFEKLLLQLNKD Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP SSTTTTEQSSDSSSLPPPPPVQVTKPIPNEM-------------VSFYTFIGTQFEMILG ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -------------------------K---K-----------------DSAVGIHLLGVVL FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------------------SKYEEL-------------DSLY-----ASVGKVI CC1G_00839_Ccin_ATM -------------------------NRHRQLWEVPDRKGERSRKDWLV-----M------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -------------------------AGDTE-----------------H-----AAFHQYI AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -------------------------PGHDEL-------------DQLY-----SNLQRTV ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ----------------------------------------------FAALERMLLDLPQL GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP YEGLTNYEKA----TNAN-PSQL---FGT----LMILK-SACSNNPS--YI--------- SMG1_Hsap_SMG1 T---LN-----------PDQDVSQ---WT----TADN-DEG----HG--NN--------- FRAP_Hsap_FRAP ----DNSPGR----I-VS-----I---KL----LAAIQ-LFGANL--------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP AENLTSYEKS----PQPN-ASSL---FGT----LMILK-ACTTNNAS--YI--------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 L---SG-----------CAKEIER---SA----LDDLSLEE----LL--SM--------- FRAP_Mmus_FRAP ----DNSQGR----I-VS-----I---KL----LAAIQ-LFGANL--------------- DNAPK_Mmus_DNAPK ANNLPPYDPN----CDIT-S---AMYFE------------ALVNNMS--FVKYKEVYAAA ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP HEHFGSLLKN----LSG-PVLGV---LGA----FSLLR-TICGHEPA--YL--------- B0261.2_Cele_FRAP ----DKTKER----V-LT-----V---KV----MESIQ-KLTHCI--------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -------------------------------------K-MICSQKPEPSM---------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ANDLPPYDPQ----CGIQ-S---SEYFQ------------ALVNNMS--FVRYKEVYAAA TOR_Dmel_FRAP ----DNSKDR----M-VT-----R---RL----LQALQ-KFGSTL--------------- SMG1_Mmus_SMG1 T---LN-----------PDQDVSQ---WT----TADN-DEG----HG--SN--------- TRRAP_Mmus_TRRAP YEGLTNYEKA----TSAN-PSQL---FGT----LMILK-SACCNNPS--YI--------- smg-1_Cele_SMG1 VIVRKN-----------SDKKLNK---SS----TEDPN-QSPPLKYS--VQ--------- TOR1_Scer_FRAP ----DKSSDK----V-LS-----R---RV----LRLLE-SFGPNL--------------- TOR2_Scer_FRAP ----DQSNKR----I-VP-----I---RI----LKSLV-TFGPNL--------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK SNGYPAYDKE----YDSN-TISEFKFYQ------------VLLDHL----QDFKELYDAA SMG1_Ddis_SMG1 ----------------------------------------------R--RD--------- Tor_Ddis_FRAP ----DRSPKR----S-PT-----T---KV----LRALE-VFGTNL--------------- TRRAP_Ddis_TRRAP AFDKNY-----------N-----L---SI----LSNIK-VFSDHSES--FI--------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ANNLHPLSRT----CDVD-A---DRFYS------------ALASNID---NRYKAVHGAA FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP YEGLTAYEKA----TNGSPTSSL---FGT----LMILK-AACTNNIS--YI--------- CC1G_00839_Ccin_ATM ----------------A-KESIL---YGL----LAL------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----DTSDKR----IAVQ-----I---KI----FDAFL-TFGANI--------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP HDALGE--------NLLN-SPSL---RGS----LLMLK-SVISVTPE--RL--------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP FEGLTTYEKA----STS-ASTNL---NCT----LMILK-ACCVNDPT--YI--------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -A--ERNADY----A-YV-----A---SL----LHTFE-VFGASL--------------- SMG1_Smoe_SMG1 V--------------------------------QSES-SAA----NT--SE--------- GK008_Glam_FRAP -SQEISDSAK----K-LL-----I---RA----CRSVV-ALSSLF--------------- GK009_Glam_PIKK-Unclassified -------QGRIENTK-------------LKQSAEQVLK-TYGTLL--------------- TRRAP_Hsap_TRRAP ---------------DRLISVFMRSL-QK--------------MV--REHLNPQAA---- SMG1_Hsap_SMG1 ---------------QLRLVLLLQYL-ENLEKLMYNAYEGCANA----L----------- FRAP_Hsap_FRAP ---------------DDYLHLLLPPI-VK--------------LFD--AP------EAP- mei-41_Dmel_ATR ---------------------AVLAL-TS--------------LC--RGYQ-F------- CG2905_Dmel_TRRAP ---------------DRILVQFIRVL-NH--------------LT--RDHINTIGGNTVI CG6535_Dmel_ATM ----------------------LG------------------------VVCHS------- CG4549_Dmel_SMG1 ---------------QSNLSLLLGFL-DALEKLIYNAAEGSAFA----L----------- FRAP_Mmus_FRAP ---------------DDYLHLLLPPI-VK--------------LFD--AP------EVP- DNAPK_Mmus_DNAPK AEVLGLILQYITERKHVIAELVCELV-IK--------------QL--KQ----HQ-NT-- ATR_Mmus_ATR ---------------------AYGLL-ME--------------LT--RAYLAY------- ATM_Mmus_ATM ----------------------TL------------------------IMLTA------- C47D12.1_Cele_TRRAP ---------------DHLMPSFVKVM-ER--------------AA--KEHLAYVAN---- B0261.2_Cele_FRAP ---------------VQHLHLVLPPL-LI--------------ILD--DF------SLK- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR --------------------------------------------------IEQ------- TEL1_Scer_ATM ---------------------K-LWF-AA--------------L----SRRIL------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ----------------------TF------------------------IMLTY------- ATR_Hsap_ATR ---------------------AYGLL-ME--------------LT--RAYLAY------- DNAPK_Hsap_DNAPK AEVLGLILRYVMERKNILEESLCELV-AK--------------QL--KQ----HQ-NT-- TOR_Dmel_FRAP ---------------GYYLPLILPPI-VK--------------LFD--SP------YVP- SMG1_Mmus_SMG1 ---------------QLRLVLLLQYL-ENLEKLMYNAYEGCANA----L----------- TRRAP_Mmus_TRRAP ---------------DRLISVFMRSL-QK--------------MV--REHLNPQTA---- smg-1_Cele_SMG1 ---------------WLRVHLLLKLI-VVLEKLMNSAIHGGSSVF--NL----------- TOR1_Scer_FRAP ---------------EGYSHLITPKI-VQ--------------MAE--FT------S--- TOR2_Scer_FRAP ---------------EDYSHLIMPIV-VR--------------MTE--YS------A--- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ---------------------AAELIEKY--------------LA--K-FVLS------- DNAPK_Ddis_DNAPK SEVCGMILLYLSKQQQSQQQQQQSIF-PQ--------------LL--KDKINSILNNN-- SMG1_Ddis_SMG1 ---------------FKKIKILLHFM-ESMEKLIFSTVNGSVLV---------------- Tor_Ddis_FRAP ---------------DDYLHLVIPAI-VK--------------LFE--QV------DVT- TRRAP_Ddis_TRRAP ---------------DPYISLIVKVL-IR--------------LT--RNYLSQDSDGGT- ATMa_Spur_ATM ----------------------NS------------------------VILHL------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK AEVIGMAMKQMAEVDKIPDSHLHEVT-YK--------------EL--SQL---HLGSG-- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ---------------DRLITVFMRAL-QK--------------MA--KEHLSP------- CC1G_00839_Ccin_ATM --------------------------------------------------LEHESS---- CC1G_08126_Ccin_ATR ---------------------IINLI-EE--------------LV--DAFRS-------- CC1G_00894_Ccin_FRAP ---------------EEYLHLVIPII-VK--------------SYE--RS------DAP- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ---------------NTLSTPLMKLL-SK--------------LA--KDHIHS------- AqueK043_Aque_ATM -----------------------A------------------------SVLES------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ---------------DKFLVPFVKVM-QK--------------LH--KEHLLS------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ---------------------VFQLINQH--------------LT--R-VLRA------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ---------------DEHMHLVLPAL-VR--------------LFKPDVS------NAP- SMG1_Smoe_SMG1 ---------------LLPMRLLLELV-DSLQRNIYNAYEGSL-V----L----------- GK008_Glam_FRAP ---------------SNHIHLIVDLL-CS--------------GIR--KQ------KLG- GK009_Glam_PIKK-Unclassified ----------------DYRT------------------------LN--PS------NGP- TRRAP_Hsap_TRRAP SGSTE---------------------------AT-S-------GTS-------------- SMG1_Hsap_SMG1 ----------------------------------------------TSPPKV-------- FRAP_Hsap_FRAP -------------------------------------------LPS-------------- mei-41_Dmel_ATR QQNTK---------------------------HV-D-------SFS-------------- CG2905_Dmel_TRRAP SQSPD---------------------------SN-A-------LPL-------------- CG6535_Dmel_ATM LDTSL---------------------------FQ-FDPKTHEGLV--------------- CG4549_Dmel_SMG1 ----------------------------------------------RPPEKQ-------- FRAP_Mmus_FRAP -------------------------------------------LPS-------------- DNAPK_Mmus_DNAPK MEDKFIVCLNKIAKGFPPLADRFLNALFFLLPKF-H-------GVM-------------- ATR_Mmus_ATR ADNSR---------------------------AQ-D-------SAA-------------- ATM_Mmus_ATM LNNTL---------------------------VE-DSVKIRSAAA--------------- C47D12.1_Cele_TRRAP SQDGN---------------------------MV-K-------NVA-------------- B0261.2_Cele_FRAP -------------------------------------------LSI-------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -KTID---------------------------ELS------------------------- TEL1_Scer_ATM QQ---------------------------------------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM LNNTL---------------------------VE-DCVKVRSAAV--------------- ATR_Hsap_ATR ADNSR---------------------------AQ-D-------SAA-------------- DNAPK_Hsap_DNAPK MEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKF-H-------GVL-------------- TOR_Dmel_FRAP -------------------------------------------QQV-------------- SMG1_Mmus_SMG1 ----------------------------------------------TSPPKV-------- TRRAP_Mmus_TRRAP SGSTE---------------------------ATAA-------GTS-------------- smg-1_Cele_SMG1 ----------------------------------------------TEIPVS-------- TOR1_Scer_FRAP -------------------------------------------GNL-------------- TOR2_Scer_FRAP -------------------------------------------GSL-------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR PSNPT---------------------------PQ-D-------RAG-------------- DNAPK_Ddis_DNAPK ENQRAFSCLYFIGLHYPLFLQGFYGKIFNLLPQI-S-------NET-------------- SMG1_Ddis_SMG1 ----------------------------------------------QSLNNK-------- Tor_Ddis_FRAP -------------------------------------------TQV-------------- TRRAP_Ddis_TRRAP -------------------------------------------GSLANKPLSSSGSTSQT ATMa_Spur_ATM LKEYL---------------------------TD-PCVDVVAASA--------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK KEVIFITCLHKIHLHYPVFTDRFMNKLLFMLPSI-H-------GQP-------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -SSTD---------------------------AT-S-------LAS-------------- CC1G_00839_Ccin_ATM SLVHN---------------------------AY-N-------TLR-------------- CC1G_08126_Ccin_ATR TSDMK---------------------------FQ-T-------NLA-------------- CC1G_00894_Ccin_FRAP -------------------------------------------SSL-------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP TPNTP---------------------------AF-D-------SNV-------------- AqueK043_Aque_ATM LSVLL---------------------------SD-VSISVVKASS--------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP SNSTA---------------------------EI-Q-------TVS-------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ASDTD---------------------------VQ-D-------AAA-------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------------------------------------------MDI-------------- SMG1_Smoe_SMG1 ----------------------------------------------EAPSFS-------- GK008_Glam_FRAP -------------------------------------------KEL-------------- GK009_Glam_PIKK-Unclassified -------------------------------------------RDS-------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 --------------IRTF--FYTNRQTCQDWLTRIRLS------IMRVGLLAGQPAVTVR FRAP_Hsap_FRAP ---------------RKAAL---------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 --------------VAAF--FRLNNPTCQSWFNRIRIG------VVIIAMHVQQPELVIR FRAP_Mmus_FRAP ---------------RKAAL---------------------------------------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ---------------RNTAL---------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ---------------SMVAL---------------------------------------- SMG1_Mmus_SMG1 --------------IRTF--FYTNRQTCQDWLTRIRLS------IMRVGLLAGQPAVTVR TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 --------------SRQF--FTVNAASCEVWLNRVYYP------ALLVAYFNGYYGLVIR TOR1_Scer_FRAP ---------------QRSAI---------------------------------------- TOR2_Scer_FRAP ---------------KKISI---------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 --------------ETQF--FRHNVRVCEDWFSRIRVN------LLKASILSSSTPDIIR Tor_Ddis_FRAP ---------------RTLAI---------------------------------------- TRRAP_Ddis_TRRAP GGASQTATSASNVVLKKSNSEI-------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ---------------RKRAI---------------------------------------- CC1G_06302_Ccin_PI3K --------------------QLTSEEKDLIWKFRFYLARDKRGLTKFL---KSVTWRDSS CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ---------------RRSTI---------------------------------------- SMG1_Smoe_SMG1 --------------SGLF--FRANKKVCEEWFARIREA------LVNASSVIQCHFGTAQ GK008_Glam_FRAP ---------------RFALL---------------------------------------- GK009_Glam_PIKK-Unclassified ---------------QKGPE---------------------------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 HGFDLLTEMKTT-----SLSQGNELE--------------------VT-------IMMVV FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 YAQQILVN---------SKTQDPTYS--------------------QA-------IVYMA FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 HGFDLLTEMKTN-----SLTQGSELE--------------------VT-------IMMVV TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 FGSNALSHFARQK--------DGDND--------------------KKIVNGVCTASLMS TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 HASLRVQDIQANRFVLDSNTAHFELE--------------------FC-------ILHLA Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K EVKQAVEELL---------------------PQWTEIDTDDALEL--------------- CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 HALFRLHDLRPM-----ALAALRDLPRSQAADGGLSLKVKLQQDVFRV-------LRHGS GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 EALCELHCPEAIQGIAVWSSSIV-------------------------------GK---- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 WSLVSCQEADSLRGLRLWARGKS-------------------------------CK---- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 EALCELHCPEAIQGIAVWSSSAV-------------------------------GK---- TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 LSMAVLGEPMEIVGLRRKVREEF-------------------------------GTDMG- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 NALQQLNETESLQGLSNWSDINLNNSDNNNNNNNKNNNNNNNSTFFNNGNINKYTL---- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 LALCKLHESDSILGLQAWAVTAF-------------------------------AGLILE GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP --------------------------ELVMLSLEL-VK-------TR-------L----- SMG1_Hsap_SMG1 ----------NLLWINSVAQQAEGRFEKASVEYQE-HL-------CAMTGVDCCISSFDK FRAP_Hsap_FRAP ------------------------------------------------ETVDRLTESLDF mei-41_Dmel_ATR --------------------------LAIQETLAICGISP----KE-------------- CG2905_Dmel_TRRAP --------------------------ELLVLSLEL-IK-------NR-------I----- CG6535_Dmel_ATM --------------------------SVAIQ-------------VV-------------- CG4549_Dmel_SMG1 ----------SYKWLKYAADQAAGKRESALAGYRT-IL-------AEKE----------- FRAP_Mmus_FRAP ------------------------------------------------ETVDRLTESLDF DNAPK_Mmus_DNAPK --------------------------KTLCLEV---VL-------CR-------AEEI-- ATR_Mmus_ATR --------------------------YAIQELLSIYDCRE----MQ-------------- ATM_Mmus_ATM --------------------------TCLKN-------------IL-------------- C47D12.1_Cele_TRRAP --------------------------ELLCACMEL-VR-------PR-------V----- B0261.2_Cele_FRAP ------------------------------------------------STVLHMTQQVDV atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ---------------------------------------EVQRERS-------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM --------------------------TCLKN-------------IL-------------- ATR_Hsap_ATR --------------------------YAIQELLSIYDCRE----ME-------------- DNAPK_Hsap_DNAPK --------------------------KTLCLEV---VL-------CR-------VEGM-- TOR_Dmel_FRAP ------------------------------------------------ETINNLACQLDF SMG1_Mmus_SMG1 ----------NLLWINSVAQQAEGRFEKASVEYQE-HL-------CAMTGVDCCISSFDK TRRAP_Mmus_TRRAP --------------------------ELVMLSLDL-VK-------TR-------L----- smg-1_Cele_SMG1 -----------QSLMEALGEMANARYETALVALEA-VL-------VT------------- TOR1_Scer_FRAP ------------------------------------------------ITIGKLAKDVDL TOR2_Scer_FRAP ------------------------------------------------ITLGRLAKNINL TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR --------------------------YAIQEILKCCQ----------------------- DNAPK_Ddis_DNAPK --------------------------RLIALNI---IH-------WC-------VEDI-- SMG1_Ddis_SMG1 ----------KLPWMKGVILRSKQKFEESISSLLS-VP---------------------- Tor_Ddis_FRAP ------------------------------------------------QTIGRLCKKLNF TRRAP_Ddis_TRRAP -------------------------ISGLCKTYGF-LK-------TK------------- ATMa_Spur_ATM --------------------------KCLKM-------------VL-------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK --------------------------KTECLQI---IT-------AR-------IEHI-- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --------------------------ELLIISLDL-VK-------NR-------V----- CC1G_00839_Ccin_ATM --------------------------L---MMKEL-PG-------GL-------S----- CC1G_08126_Ccin_ATR --------------------------YPIQELLKLCGFTS-----D-------------- CC1G_00894_Ccin_FRAP ------------------------------------------------QTIDGLSRRVNF CC1G_06302_Ccin_PI3K --------------------LGPSTVDSRVRAFAV-KQ-------LSRAD---------- CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --------------------------RLITAILDI-SR-------NN-------V----- AqueK043_Aque_ATM --------------------------HCLRD-------------VL-------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP --------------------------ELLQLSIDM-CK-------LR-------V----- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR --------------------------LAIQELLKLTGCHE----AR-------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------KTFSRLLPCMQV SMG1_Smoe_SMG1 DVHKVSSPLGPVGWMNGLAFEARGEFERAAAHYSQ-LF-------QSEET---------- GK008_Glam_FRAP ------------------------------------------------DTLSRLTICTNL GK009_Glam_PIKK-Unclassified ------------------------------------------------GKVTRGS-CGYF TRRAP_Hsap_TRRAP -------------------------------AVMSMEMRKNFIQA--------------- SMG1_Hsap_SMG1 SVLTLANAGRNSASPKHSLNGESRKTVLSKP----------------------------- FRAP_Hsap_FRAP -----------------------------------TDYASRIIH---------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -------------------------------FVMSVEIRKLFIGT--------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 -----------------------------LQ----------------------------- FRAP_Mmus_FRAP -----------------------------------TDYASRIIH---------------- DNAPK_Mmus_DNAPK -------------------------------TGLYLQLKSKDFLQ--------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -------------------------------DHISMEIKRSIVG---------------- B0261.2_Cele_FRAP -----------------------------------SAYAPRMMQ---------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR --------------------------------------T--------------------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK -------------------------------TELYFQLKSKDFVQ--------------- TOR_Dmel_FRAP -----------------------------------TDFSSRIIH---------------- SMG1_Mmus_SMG1 SVLTLANAGRNSASPKHSLNGESRKTVLSKS----------------------------- TRRAP_Mmus_TRRAP -------------------------------AVMSMEMRKNFIQT--------------- smg-1_Cele_SMG1 ------------------------------DAA-TNETLKMIIQL--------------- TOR1_Scer_FRAP -----------------------------------FEMSSRIVH---------------- TOR2_Scer_FRAP -----------------------------------SEMSSRIVQ---------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -------------------------------QDLYTKLKSNNIEN--------------- SMG1_Ddis_SMG1 -----------------------------PM----------------------------- Tor_Ddis_FRAP -----------------------------------SDYASRIIH---------------- TRRAP_Ddis_TRRAP ------------------------------TTKLNSDQRNAFIQ---------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -------------------------------DNAFIEMKNKNILA--------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------------------------GVMSTDMRRNFVQ---------------- CC1G_00839_Ccin_ATM -------------------------------AEKLW------SR---------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP -----------------------------------SDHASRIIH---------------- CC1G_06302_Ccin_PI3K ------------------------------D----------------------------- CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -------------------------------TFL-GEQRRWLLTA--------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -------------------------------TAMPQDCRKAFFN---------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -----------------------------------TAHVSSLLH---------------- SMG1_Smoe_SMG1 ------------------------------L----------------------------- GK008_Glam_FRAP -----------------------------------SRFGASIIH---------------- GK009_Glam_PIKK-Unclassified -----------------------------------TDFITRVIEGGDLYAASCITELNEY TRRAP_Hsap_TRRAP ----------------------I-----------------------------LTSLIEK- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------------------P-----------------------------IVRTLD-- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ----------------------I-----------------------------LVSLIEK- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------------------P-----------------------------IVRTLD-- DNAPK_Mmus_DNAPK ----------------------------------------------------VMRHRDD- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ----------------------G----------------------------IIAELIIK- B0261.2_Cele_FRAP ----------------------S-----------------------------WHHNIS-- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ----------------------------------------------------VMRHRDD- TOR_Dmel_FRAP ----------------------P-----------------------------LVRVLD-- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ----------------------I-----------------------------LTSLIEK- smg-1_Cele_SMG1 ----------------------A-----------------------------MVDILNRI TOR1_Scer_FRAP ----------------------S-----------------------------LLRVLS-- TOR2_Scer_FRAP ----------------------A-----------------------------LVRILN-- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ----------------------------------------------------LIRIREG- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------------------P-----------------------------LARVLD-- TRRAP_Ddis_TRRAP ----------------------S-----------------------------LLVLIER- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ----------------------------------------------------LLTHKDE- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----------------------V-----------------------------LTSVIEK- CC1G_00839_Ccin_ATM ----------------------EYLEELQLLRHYPRLSSKRPVRSLSLLQESDHYVEMS- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----------------------P-----------------------------MVRVLD-- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ----------------------------------------------------LVILIEK- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ----------------------I-----------------------------LTSLIEK- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------------------P-----------------------------LLSVLD-- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------------------P-----------------------------ILEVIM-- GK009_Glam_PIKK-Unclassified FSTLGEDQKTVYISSKIYQRMQS-----------------------------FVELLPI- TRRAP_Hsap_TRRAP -SP--------------------DA--KILRAVV----------------KI-------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -Q---------------------SP--ELRSTAM----------------DT-------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -ST--------------------EV--KIIKCII----------------KM-------- CG6535_Dmel_ATM -----------------------------------------------------N------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -Q---------------------SP--ELRSTAM----------------DT-------- DNAPK_Mmus_DNAPK -ER--------------------QK--VCLDIVY----------------KM-------- ATR_Mmus_ATR -----------------------------------------------------S------ ATM_Mmus_ATM -----------------------------------------------------A------ C47D12.1_Cele_TRRAP -SN--------------------HD--KIIQTSV----------------KL-------- B0261.2_Cele_FRAP -----------------------TA--EMRDKLL----------------LL-------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM -----------------------------------------------------T------ MEC1_Scer_ATR ---------------------------------ATLIKFLQSQKLPVVKENL-------- ATM_Hsap_ATM -----------------------------------------------------A------ ATR_Hsap_ATR -----------------------------------------------------T------ DNAPK_Hsap_DNAPK -ER--------------------QK--VCLDIIY----------------KM-------- TOR_Dmel_FRAP -A---------------------EP--ELRDQAM----------------TT-------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -SP--------------------DA--KILRAVV----------------KI-------- smg-1_Cele_SMG1 RLP--------------------QA--TDYYKVV----------------LF-------- TOR1_Scer_FRAP -STT-------------------SD--ELSKVIM----------------NT-------- TOR2_Scer_FRAP -NG--------------------DR--ELTKATM----------------NT-------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -EI--------------------QV--VILRILY----------------KL-------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -ST--------------------ES--ELREETL----------------NT-------- TRRAP_Ddis_TRRAP -SN--------------------DV--ELLSEII----------------KV-------- ATMa_Spur_ATM -----------------------------------------------------G------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -AD--------------------QL--TSLKLVD----------------GM-------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -SP--------------------DA--KVLKTIV----------------KM-------- CC1G_00839_Ccin_ATM -SK--------------------FS--DWVKY-------------------V-------- CC1G_08126_Ccin_ATR ---------------------------------------------------LVN------ CC1G_00894_Ccin_FRAP -GN--------------------NN--ELRMAVF----------------DT-------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------EESL----------------DA-------- CC1G_00331_Ccin_TRRAP -SK--------------------SI--PLCKYIL----------------EL-------- AqueK043_Aque_ATM -----------------------------------------------------S------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -ST--------------------DI--KLLKSIA----------------RT-------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -----------------------------------------------------GVSRPPS DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -GT--------------------KD--ELRNDAV----------------DA-------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -EADPCTSVEHNKNANPEKGLNPMN--IVSYKAF----------------EV-------- GK009_Glam_PIKK-Unclassified --V---------------------IRDTEKRHLL----------------NT-------- TRRAP_Hsap_TRRAP -------------------VE-------------------------------------EW SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -------------------LSSL---------------------------------VFQ- mei-41_Dmel_ATR -----------QKKVQL------------------------------------------W CG2905_Dmel_TRRAP -------------------LD-------------------------------------EW CG6535_Dmel_ATM ----------SKPGSNI------------------------------------------M CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -------------------LSSL---------------------------------VFQ- DNAPK_Mmus_DNAPK -------------------VA-------------------------------------K- ATR_Mmus_ATR ----------NGPGYQL------------------------------------------W ATM_Mmus_ATM ----------TKIGHIF------------------------------------------W C47D12.1_Cele_TRRAP -------------------LG-------------------------------------AM B0261.2_Cele_FRAP -------------------LIEI---------------------------------IKQ- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ----------NFNNEVH------------------------------------------L MEC1_Scer_ATR -------------------VI-------------------------------------AW ATM_Hsap_ATM ----------TKTGHSF------------------------------------------W ATR_Hsap_ATR ----------NGPGHQL------------------------------------------W DNAPK_Hsap_DNAPK -------------------MP-------------------------------------K- TOR_Dmel_FRAP -------------------LRSL---------------------------------AKQ- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -------------------VE-------------------------------------EW smg-1_Cele_SMG1 -------------------GEES----------------------------------N-- TOR1_Scer_FRAP -------------------LSLL---------------------------------LIQ- TOR2_Scer_FRAP -------------------LSLL---------------------------------LLQ- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -------------DTKL------------------------------------------S DNAPK_Ddis_DNAPK -------------------VQ-------------------------------------K- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -------------------LCAL---------------------------------VYQ- TRRAP_Ddis_TRRAP -------------------VDYL---------------------------------ISI- ATMa_Spur_ATM ----------TRSGQTF------------------------------------------Y ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -------------------LP-------------------------------------K- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------------VE-------------------------------------EW CC1G_00839_Ccin_ATM -------------------SV-------------------------------------LI CC1G_08126_Ccin_ATR ----------SGRAVPLRTRN-------------------------------------RW CC1G_00894_Ccin_FRAP -------------------LCSL---------------------------------VAQ- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ----------------------L---------------------------------LVE- CC1G_13883_Ccin_PI4K -------------------IASDVEYNSVIRQEFAQTVISKHRALLTKYIPLRYSEIRY- CC1G_00331_Ccin_TRRAP -------------------SR-------------------------------------TW AqueK043_Aque_ATM ----------TNSGASV------------------------------------------L AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -------------------VD-------------------------------------DW ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR SSSKPTQKSKLQLGDRL------------------------------------------W DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------------------ICVL---------------------------------ATV- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -------------------LHFI---------------------------------CAQ- GK009_Glam_PIKK-Unclassified --------------------SLV---------------------------------ITN- TRRAP_Hsap_TRRAP VK-------------NNSPMA--------------------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------------LG-KKYQIFIPMVNKVLV-------------------------- mei-41_Dmel_ATR QSLPA----R---MRQLM------------------------------------------ CG2905_Dmel_TRRAP IK-------------TKEPNV--------------------------------------- CG6535_Dmel_ATM ERYKNLR-IFADK--STA------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------------LG-KKYQIFIPMVNKVLV-------------------------- DNAPK_Mmus_DNAPK ----------------LK------------------------------------------ ATR_Mmus_ATR KRFPE----H---VREIL------------------------------------------ ATM_Mmus_ATM ENYKT----SADPMLTYL------------------------------------------ C47D12.1_Cele_TRRAP IS-------------TQDM----------------------------------------- B0261.2_Cele_FRAP ----------------LG-KFFDIFKRGVDQKLR-------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM KNFEM----V---FRHPE------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM EIYKM----TTDPMLAYL------------------------------------------ ATR_Hsap_ATR RRFPE----H---VREIL------------------------------------------ DNAPK_Hsap_DNAPK ----------------LK------------------------------------------ TOR_Dmel_FRAP ----------------LG-KKYLVFVPMVQRTLN-------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP VK-------------NNSPMA--------------------------------------- smg-1_Cele_SMG1 -----------------------------------DSTITEDFRSV-------------- TOR1_Scer_FRAP ----------------MG-TSFAIFIPVINEVLM-------------------------- TOR2_Scer_FRAP ----------------LG-TDFVVFVPVINKALL-------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR EKLSN----E---CNDII------------------------------------------ DNAPK_Ddis_DNAPK ----------------RD------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------------LG-SDYAIFIPMVGKVLA-------------------------- TRRAP_Ddis_TRRAP ----------------SP-SPSPSTTPVVTETTIPS---------TTTTTTTAATTTTTT ATMa_Spur_ATM EQYRD---QNIDTLLAYL------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ----------------LK------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP VK-------------AKTPLM--------------------------------------- CC1G_00839_Ccin_ATM SD-------------ILSS----------------------------------------- CC1G_08126_Ccin_ATR AGLKK----E---VMNAV------------------------------------------ CC1G_00894_Ccin_FRAP ----------------LG-SDFAIFVPTINKATL-------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ----------------IL-TDDLDFEP--------------------------------- CC1G_13883_Ccin_PI4K ----------------LS-AGQAIFILSMYDIESM------------------------- CC1G_00331_Ccin_TRRAP AM-------------NRQ------------------------------------------ AqueK043_Aque_ATM QKLEHSVSQDDNQWFNVL------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP VK-------------NRYDLP--------------------------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR SRFSD----A---VKEII------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------------LG-AEFTMFLPSVRKLLQ-------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------------FG-VSVTLYIPVITECLL-------------------------- GK009_Glam_PIKK-Unclassified ----------------AS-SFFAIFIDLFLKLLQ-------------------------- TRRAP_Hsap_TRRAP ----------------------------ANQTPT-LREKSILL----------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -----------------------------EPMLH-SCYTC--V--HR------------- CG2905_Dmel_TRRAP ----------------------------MTQVPS-IREKSALL----------------- CG6535_Dmel_ATM -----------------------------STFLH-S------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK -----------------------------PI------ELRELL----------------- ATR_Mmus_ATR -----------------------------EPHLN-TRYKS--S--QK------------- ATM_Mmus_ATM -----------------------------QPFRT-S------------------------ C47D12.1_Cele_TRRAP -------------------------------EFT-ILTVLPLL----------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM -----------------------------QPHMIYQRIST--F--NK------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----------------------------QPFRT-S------------------------ ATR_Hsap_ATR -----------------------------EPHLN-TRYKS--S--QK------------- DNAPK_Hsap_DNAPK -----------------------------PV------ELRELL----------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ----------------------------ANQTPT-LREKSILL----------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -----------------------------KPYYS-SEYML--PLFSKKNNNLVGGGGGNG DNAPK_Ddis_DNAPK -----------------------------TTFGT-VNQILSLL----------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP TPSTTTTAATTTTAPTTTETTTTAATTTITPFLT-IKEKINFL----------------- ATMa_Spur_ATM -----------------------------YPFKT-S------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -----------------------------PS------ELRYLL----------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----------------------------LNQSPS-PREKTILL----------------- CC1G_00839_Ccin_ATM -------------------------------RDP-TYGQLY------------------- CC1G_08126_Ccin_ATR -----------------------------TPLLE-GRFSF--S----------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -----------------------------DPYPT-AKEKASLL----------------- AqueK043_Aque_ATM -----------------------------EPFKQ-N------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ----------------------------SHSGPS-IREKSLLL----------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -----------------------------SPCLT-SKYLL--K--VS------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------VKMMTYIEKRF--------------PEDL------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -----PS-----TCL------------------QQ------------------------- CG2905_Dmel_TRRAP ------VKLMQNVEKKF--------------TDEI------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------NPVVEFVSHPS-----------------P------------------------- ATR_Mmus_ATR -----ST---DWSGV------------------TK------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------VRIQSIIVTKF--------------KNCK------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM -----EA---ELYDS------------------TEVFFISECILTYLVGYSIGNSESEFC MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -----ST---DWSGV------------------KK------------------------- DNAPK_Hsap_DNAPK ------NPVVEFVSHPS-----------------T------------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------VKMMTYIEKRF--------------PEDL------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR NGGGNGV---SSSGS------------------SS------------------------- DNAPK_Ddis_DNAPK ------LSNNWFTSNVT----------------NE------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------IKLGR-VD-Q---------------LSNA------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------PAVKDFVSHPS-----------------P------------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------VKLMQYVEKRF--------------PDES------------------------- CC1G_00839_Ccin_ATM ----------SILSTDV--------------STAE------------------------- CC1G_08126_Ccin_ATR ------N---TVPAV------------------KL------------------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K --------AKK-SN-KDVLRRIVLKDQERTERR--------------------------- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------QKMAHFEGR------------------GE------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------SRMMSFFEKRF--------------PDDL------------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ----------GAPMP------------------SG------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -------------------------------------ELNAQFLDLVNYV---YRDETLS SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -------------------------------------P---------------------- CG2905_Dmel_TRRAP -------------------------------------ELNIQFLEIINFI---YRDEILK CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK -------------------------------------TCREQMYNILMWIHDNYRDQESQ ATR_Mmus_ATR -------------------------------------P---------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -------------------------------------DLIADYLVVVITV---FENSEYR B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM FRDNIMNENKDKVAPLDKDVLNAIYPLANNFGMESFIC---------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -------------------------------------P---------------------- DNAPK_Hsap_DNAPK -------------------------------------TCREQMYNILMWIHDNYRDPESE TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -------------------------------------ELNAQFLDLVNYV---YRDEALS smg-1_Cele_SMG1 -------------------------------------ELLTKFEKLNN------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -------------------------------------C---------------------- DNAPK_Ddis_DNAPK -------------------------------------YSRSLYYDIIIYIYNNFIEYQDQ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -------------------------------------ELSLSYYKLVLSF---YSESNSS ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -------------------------------------SCRDTMYSILMWIYDNYRDEDKR FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------------------------------ELNAQFLELVNWV---YRDDSLA CC1G_00839_Ccin_ATM -------------------------------------E-MFPVLVYALLQ---GEKISPQ CC1G_08126_Ccin_ATR -------------------------------------PVYP------------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -------------------------------------PLFTSYLELIYDV---YTEPALR AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -------------------------------------ELMAMFLDTVLFV---YKDDHLS ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -------------------------------------P---------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP GSE--------LTAKL----EPAFLSGLRCA-QPLIRAKFFEVFDNSM----K--R---- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------------------------R----------------HRI----N--H---- mei-41_Dmel_ATR ----------------------LFGSHY-------------------------------- CG2905_Dmel_TRRAP QTE--------LTNKL----EGAFLNGLRFQ-NPNVRSKFFEILDSSM----R--R---- CG6535_Dmel_ATM ------------------------------------NK------Q-IR----R--I---- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------------------------R----------------HRI----N--H---- DNAPK_Mmus_DNAPK NDE--------DSQEIFKLAKDVLIQGLIDE-NVGLQLIIRNFWSHE-TRL-P--S---- ATR_Mmus_ATR ----------------------IYLSKL-------------------------------- ATM_Mmus_ATM ------------------------------------RKKFLEVPR-SV----K--E---- C47D12.1_Cele_TRRAP NSE--------AGSRL----WEGFFWGLKSS-DPQTREKFSIVWEKTWPHMAT--V---- B0261.2_Cele_FRAP ----------------------------D----------------YNL----D--K---- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ----------------------DTYLS--------------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------RKKFLEVPR-FD----K--E---- ATR_Hsap_ATR ----------------------IYLSKL-------------------------------- DNAPK_Hsap_DNAPK TDN--------DSQEIFKLAKDVLIQGLIDE-NPGLQLIIRNFWSHE-TRL-P--S---- TOR_Dmel_FRAP ----------------------------K----------------HRI----V--D---- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP GSE--------LTAKL----EPAFLSGLRCA-QPLIRAKFFEVFDNSM----K--R---- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ----------------------------K----------------KHI----Q--H---- TOR2_Scer_FRAP ----------------------------R----------------NRI----Q--H---- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ----------------------FYG----------------------------------- DNAPK_Ddis_DNAPK SNE--------NSKDL----VLSLLIGLSDE-SDSINKKLLQFWDNNSKTL-S--A---- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------------------------R----------------REI----Q--S---- TRRAP_Ddis_TRRAP SKQ--------ELSQL----EPCFMMGLRNTVDQGMRKSLFNILHKSI----G--T---- ATMa_Spur_ATM ------------------------------------KNKIIKLPA-ID----SCDE---- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK EGQ--------DGDEALSIAKDTLLQGLSDQ-DNYLRLRVSNFWSHE-TRL-P--K---- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP GSE--------LTSKL----EPAFLSGLRCS-QPHIRTKFFEVFNSSI----R--R---- CC1G_00839_Ccin_ATM EGPSPRALLSHHFTKV----LQYPNAGLQCV----------------QLIVDA--V---- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----------------------------R----------------NRI----S--H---- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ----------------------------R----------------SAA----G------- CC1G_00331_Ccin_TRRAP RSD--------LTTRL----ENSFLIGCRAR-DTALRERFMDLLDVSV----S--R---- AqueK043_Aque_ATM ------------------------------------KKK--------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP SNE--------LTAKL----EPAFLCGLRCP-QVSIRTKFFEVFERSV----Q--Q---- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ----------------------IFR----------------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------------------------R----------------HHL----Q--H---- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------------------------K----------------VGF----T--S---- GK009_Glam_PIKK-Unclassified ----------------------------K----------------GVTQ------KNIKL TRRAP_Hsap_TRRAP ------------------------------RVYERLLYVTCSQNW--EAMGNHFWIKQCI SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------QRYD-------------------------- mei-41_Dmel_ATR -----------------------------------------------SHNYYEEWAF--- CG2905_Dmel_TRRAP ------------------------------RLHDRLLYIICSQAW--DTIGSHYWIKQCI CG6535_Dmel_ATM ------------------------------DW------LS---IL--------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------QRYD-------------------------- DNAPK_Mmus_DNAPK ------------------------------NTLDRLLA-LNS-LY--SPKIEVHFLSLAT ATR_Mmus_ATR ------------------------------------------------GNNFAEWSS--- ATM_Mmus_ATM ------------------------------DVLEGLDAVN---LW--------------- C47D12.1_Cele_TRRAP ------------------------------DIAHRMKYIMQNQDW--SKFKHAFWLKFAL B0261.2_Cele_FRAP ------------------------------SVHY-------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -------------------------------------------LGGSRRESFSRWLTVII TEL1_Scer_ATM -----------------------------------------------VNEPYNCWLS--- MEC1_Scer_ATR ------------------------------------------TQL--TLTTSNDVFDTLL ATM_Hsap_ATM ------------------------------NPFEGLDDIN---LW--------------- ATR_Hsap_ATR ------------------------------------------------GSNFAEWSA--- DNAPK_Hsap_DNAPK ------------------------------NTLDRLLA-LNS-LY--SPKIEVHFLSLAT TOR_Dmel_FRAP ------------------------------PEYE-------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------RVYERLLYVTCSQNW--EAMGSHFWIKQCI smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------TIYD-------------------------- TOR2_Scer_FRAP ------------------------------SVYD-------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -----------------------------------------------SNMTYKKWIT--- DNAPK_Ddis_DNAPK ------------------------------SSNQRLQQFFDI-MY--SPETESKWVANSC SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------TNYE-------------------------- TRRAP_Ddis_TRRAP ------------------------------TPYQRLNYIIGVQQW--DILGTTYWIKHAL ATMa_Spur_ATM ------------------------------AFMRHVGEES---LW--------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------ETLERLISMLGC-MY--SPGTENRYLGYAT FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------RLFDRLLYLIDSQNW--EAMGSHYWLKQCV CC1G_00839_Ccin_ATM ------------------------------LHLRF----FHPGKG--DKLAYNK------ CC1G_08126_Ccin_ATR -----------------------------------------------TQSTYREWLQ--- CC1G_00894_Ccin_FRAP ------------------------------PRYE-------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -------------------------------RPS-------------------------- CC1G_00331_Ccin_TRRAP ------------------------------SVFNRLTYVLGVQNW--EALADHNWIYLAL AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------RLYDRLLYIMCSQNW--EHCGGHFWIKQCI ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -----------------------------------------------QGILFRRWMY--- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------PQFD-------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------GLLD-------------------------- GK009_Glam_PIKK-Unclassified APEAQKHMAHVSDLWAIVEPYINVSQAIGAAFYDA------------------------- TRRAP_Hsap_TRRAP ELLL---------AVCEKSTPIGTSCQGAML----------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -VLI------------------CRIVKGYTL-------------------------A--- mei-41_Dmel_ATR LWAS---------R---------------------------------------------- CG2905_Dmel_TRRAP ELLI---------LTANTMMQIQCSNEQFKI----------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -VLI------------------CRIVKGYTL-------------------------A--- DNAPK_Mmus_DNAPK NFLL---------EMTRMSPDYLNPIFEHPLSECEFQEYTIDPDWRFRST-VLTPMFIET ATR_Mmus_ATR SWAG---------Y---------------------------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP WGML---------RTIAKRPT--------------------------------------- B0261.2_Cele_FRAP -EQY------------------RKLAQRAQM--------------------SRDVLT--- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM KFAR---------S---------------------------------------------- MEC1_Scer_ATR LKLI---------DI--------------------------------------------- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR SWAG---------Y---------------------------------------------- DNAPK_Hsap_DNAPK NFLL---------EMTSMSPDYPNPMFEHPLSECEFQEYTIDSDWRFRST-VLTPMFVET TOR_Dmel_FRAP -ELL------------------SKIKSCSTL-------------------------A--- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ELLL---------AVCEKSTAIGTSCQGAML----------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -DLT------------------NRILNNDVL-------------------------P--- TOR2_Scer_FRAP -QLV------------------NKLLNNECL-------------------------P--- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR SWLS---------D---------------------------------------------- DNAPK_Ddis_DNAPK CLLF---------QLCNRSSDFTKLLFDKPLSECTFKEVQVDSSWQHRTL-NMNPLFSSS SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -LLI------------------SKLLKNQQL-------------------------M--- TRRAP_Ddis_TRRAP DLLL---------AILPNDKFVKISNFCSKL-------------------------P--- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK NLLL---------EMTSKSPDFKREIFEHPLSACKFEEVQIDHSWRQRHAAISTPKFVET FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ELLM---------ASSATSTLISNIN-TSPL----------------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR LWVT---------H---------------------------------------------- CC1G_00894_Ccin_FRAP -NLV------------------SKLLNGESL-------------------------P--- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -SLI------------------SYF----------------------------------- CC1G_00331_Ccin_TRRAP HLIL---------GAVDL------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ELII---------SVGNLEMPLKVSPMSPVL----------------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR LWCR---------R---------------------------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -SIE------------------SRLKRRDPI--------------------LVDVRP--- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -SIF------------------SLLLRREEV--------------------D----P--- GK009_Glam_PIKK-Unclassified --LLSLLLEYSDLS---------------------------------------------- TRRAP_Hsap_TRRAP ---------PSITNVIN----------------------------------L---ADS-- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------DE-E-ED---------------------------------P--------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ---------PSITSVIP----------------------------------V---NSS-- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------DE-E-ED---------------------------------P--------- DNAPK_Mmus_DNAPK QASP--SILHTQTQEGP----------------------------------L---SDQRQ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -------------------------------------------------------DPN-- B0261.2_Cele_FRAP ----------SS-V-FA---------------------------------G----S---- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK QASQ--GTLQTRTQEGS----------------------------------L---SARWP TOR_Dmel_FRAP ----------DS-Y-GA---------------------------------G--------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ---------PSITNVIN----------------------------------L---ADS-- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ----------TK-I-LE---------------------------------A----N---- TOR2_Scer_FRAP ----------TN-I-IF---------------------------------D----K---- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK QYGIDDATTD------------------------------------------ESNGDS-M SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------LT-P-GS---------------------------------G----D---- TRRAP_Ddis_TRRAP ----------TSLK-FA---------------------------------NR---N---- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK QVGQSQGSIRGSPSSQS----------------------------------MTSSGMSMG FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ---------PCITSVIN----------------------------------L---ADS-- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----------SE-A-GG---------------------------------M--------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ---------PCISSICP----------------------------------T---TTP-- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------TA-V-----------------------------------------S---- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------VT-F-YRLICEWKKKQAKKFSEYTSLASLLAMYETPVTQDT--------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------HDRAAF SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -----------------------------------------------ET-----QENS-F CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK KPGQVRATQQQYDFTPTQA------SVE---RSSFDWLTGSSIDLLADHTVFSSETLSSS ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP -NGNIQYS-----------------------------------------STQAGMRGQAN atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ----------------------------------------------FNS------DD--- ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK VAGQIRATQQQHDFTLTQT------ADG---RSSFDWLTGSSTDPLVDHTS----PSSDS TOR_Dmel_FRAP -ESELRPS-----------------------------------------R---------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------HDRAAF smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -TTD-------------------------------------------------------- TOR2_Scer_FRAP -EN--------------------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK QLDEIRATQA-PNFTLTQTAFSEFYPSSSQSYGGTNNNTGS-SQL-----SSS-SSS--- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -DGGMGAN-----------------------------------------R---------- TRRAP_Ddis_TRRAP -GNDINQQ-----------------------------------QQQQQQQ---------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK GGGQLRATQVTQNFTATQDNAA---SSH---KNGYNWLTGS-QDTFADYSSSSSA-SESS FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------QEKAAF CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP -D-WIQAE-----------------------------------------N---------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ----------------------------------------------QHS------SAYD- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------L----- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -EADIAAS-----------------------------------------SH--------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP AMVTHV----------------KQ----------------EPRERE-------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------------------------------------------LIYQHRMLRSGQG- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP VSFLSS----------------HS----------------ESFDII-------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------------------------------------------LIYQHRMLRSSQG- DNAPK_Mmus_DNAPK LLFSHK----------------RT----------------EKSQRM-------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP --NKRK----------------KD----------------QPMEVE-------------- B0261.2_Cele_FRAP NVYANNDLHERLMNGSIDSGASRQ----------------DNRDDYYRY----GVE-EKK atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK LLFAHK----------------RS----------------ERLQRA-------------- TOR_Dmel_FRAP -------------------------------------------------------F-KN- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP AMVTHV----------------KQ----------------EPRERE-------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -----------------------------------------------------YKP---- TOR2_Scer_FRAP -----------------------------------------------------EVP---- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------------------------------------------FGGDHNGHHLGED- TRRAP_Ddis_TRRAP ------------------QQQQQQQQQQQQQQQQQQQQQQQQQQQQQH------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK LLFTMGSLPK------------RT----------------AQGSR--------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP MLAAHV----------------KE----------------EPMDVE-------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP -------------------------------------------------------S-KA- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ---VHD----------------VS----------------EPPTIT-------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -----------------------------------------------------GA----- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------------------------------------------LLYMESISNKV--- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -------------------------------------------NS-E--SKEEDVEIDIE SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------DAL-A--SGPVETG---- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -------------------------------------------QTVD--DKDDVYDIDLN CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------DAL-A--SGPVETG---- DNAPK_Mmus_DNAPK -------------------------------------------SC-K--SVGPDFGTKKL ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -------------------------------------------TE-MKREEPEPMEVDEK B0261.2_Cele_FRAP EVPKVAPT----------------------------------TAR-P-TSELVTV----- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK -------------------------------------------PL-K--SVGPDFGKKRL TOR_Dmel_FRAP -------------------------------------------NE-P-FVTDRNS----- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -------------------------------------------NS-E--SKEEDVEIDIE smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -------------------------------------------AE-Q--MEAADA----- TOR2_Scer_FRAP -------------------------------------------ER-K--NYEDEM----- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------SGSQSS SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------HNN-T--STPLDI----- TRRAP_Ddis_TRRAP -------------------------------------------HQ-Q--EQPMEI----- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -------------------------------------------------------GTKQE FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------------------------------------SD-L--HKEEDVEIDIE CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP -------------------------------------------QE-----FQAPA----- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -------------------------------------------SQ-L--PEEL------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------------------------------------------E-LDGEN------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------PGDDKDAMILVVKDINFDDIGSVINYLHTSSTWFGDDMR-P-L-PAGA-I---- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP LAPGDQTSTPK--------------------------------------TK--------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------PMKKLHVST--------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ---ADRKEDC----------------------------------------Q--------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------PMKKLHVST--------- DNAPK_Mmus_DNAPK GLPDDEVDNQVKS-GTPSQADILRLRRRFLKDR----EKLSLLYAKRGLME--------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ---DSQDDSKD--------------------------------------AG--------- B0261.2_Cele_FRAP ------------------------------------------QITKQRLNK--------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK GLPGDEVDNKV-K-GAAGRTDLLRLRRRFMRDQ----EKLSLMYARKGVAE--------- TOR_Dmel_FRAP ------------------------------------------NNKNLQVTT--------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP LAPGDQTSTPK--------------------------------------TK--------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------GVAKLPINQ--------- TOR2_Scer_FRAP ------------------------------------------QVTKLPVNQ--------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK SQNNSSSKRKQKITNDPKLINNSELRRRFKKIDDRGADERIVKFARLQVKR--------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------GVKKLKANE--------- TRRAP_Ddis_TRRAP ------------------------------------------DENL-VVEQS-------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK AGAGGSRDKEARKAPSEGEKEVQRLKRRFMKDQ----SSQSAFFAKRATRQ--------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP LPQTDGGSSSS--------------------------------------ST--------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------EAPKMTVNQ--------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K --------------------------------------------------INDSLNKHQG CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -MEGVEGEG-G--------------------------------------EG--------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------GVHSLSIQENDMLNKH-- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ---------------------------------------------ELSEKDIGNQLHMLT SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ---------------------------------------------INLQKAWGAARR--- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ---------------------------------------------QI-LPNRRVTLVELV CG6535_Dmel_ATM --------------------------------------------------------K--- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ---------------------------------------------INLQKAWGAARR--- DNAPK_Mmus_DNAPK ---------------------------------------------QKLEKDIKSEFKM-- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM --------------------------------------------------------V--- C47D12.1_Cele_TRRAP ---------------------------------------------EP-KEKEKLTLELLL B0261.2_Cele_FRAP ---------------------------------------------DALMPQWKNENL--- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM --------------------------------------------------------I--- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ---------------------------------------------QKREKEIKSELKM-- TOR_Dmel_FRAP ---------------------------------------------NELRTAWQVTRR--- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ---------------------------------------------ELSEKDIGNQLHMLT smg-1_Cele_SMG1 -------------------------------------------------------TV--- TOR1_Scer_FRAP ---------------------------------------------SVLKSAWNSSQQ--- TOR2_Scer_FRAP ---------------------------------------------NILKNAWYCSQQ--- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ---------------------------------------------NIEREAYFEKSKQ-- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ---------------------------------------------QHLKNAWETSQR--- TRRAP_Ddis_TRRAP ---------------------------------------------SSVNKGNEEFKK--- ATMa_Spur_ATM --------------------------------------------------------Q--- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ---------------------------------------------KELREEVQKSQRE-- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ---------------------------------------------GP-SSEPRQQLQQLI CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ---------------------------------------------QHLKQAWDVSQV--- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K LSACMDAIAENVIRGCIGDLNVKAAQQSMPEYLSEELQKLLVASTHRIQQARE------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP --------------------------------------------------GGVGALEKLT ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP --------------------------------------------VTIPQQIWRADTC--- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP N-RHDKFLDTLRE-------------------V-K------TGALLSA------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP V-SKDDWLEWLRRL-------S-LELLK---DS--------SSPSLRS------------ mei-41_Dmel_ATR -------------------------LIDYLPSS-G------RRHLLSS------------ CG2905_Dmel_TRRAP Y-KQAEFLEANRN-------------------I-R------TDQMLVA------------ CG6535_Dmel_ATM ATKSLSYEPWMCAF-------V-SKVFQ---M----------CGWLG------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP V-SKDDWLEWLRRL-------S-LELLK---DS--------SSPSLRS------------ DNAPK_Mmus_DNAPK --KQDAQVVLYRSY-------R-HGDLPDIQ-I-Q------HSGLITP------------ ATR_Mmus_ATR -------------------------LITKVRDN-L------ASKIFTC------------ ATM_Mmus_ATM -PQSESHDIWIKTL-------T-CAFLD---SGGI------NSEILQL------------ C47D12.1_Cele_TRRAP A-GQQELLDEASN-------------------Y-D------FADALDT------------ B0261.2_Cele_FRAP T-SKDEWLQWLMKI-------R-IGFLT---YG--------SSPSLRA------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -------LKCAEM---------------------S------EDAPLSS------------ TEL1_Scer_ATM -------------------------LIHQISFN---------IPPIVC------------ MEC1_Scer_ATR -------------------------------------------YSLRI------------ ATM_Hsap_ATM -PLSENHDIWIKTL-------T-CAFLD---SGGT------KCEILQL------------ ATR_Hsap_ATR -------------------------LITKVRHD-L------ASKIFTC------------ DNAPK_Hsap_DNAPK --KQDAQVVLYRSY-------R-HGDLPDIQ-I-K------HSSLITP------------ TOR_Dmel_FRAP V-SKDDWVEWLKRL-------S-IGLLK---ES--------PSHALRA------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP N-RHDKFLDTLRE-------------------V-K------TGALLSA------------ smg-1_Cele_SMG1 N-EKRQVVDWSARE-------R-FQFVE---SA----------F-SQT------------ TOR1_Scer_FRAP R-TKEDWQEWSKRL-------S-IQLLK---ES--------PSHALRA------------ TOR2_Scer_FRAP K-TKEDWQEWIRRL-------S-IQLLK---ES--------PSACLRS------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -------------------------LLFKTKGS-PGSANNDLDSIFMA------------ DNAPK_Ddis_DNAPK --ARENQITMIRKY-------R-VGELPDIQ-I-K------LQDIIKP------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP S-TKEDWGEWIRRF-------S-VELLR---ES--------PSPALRS------------ TRRAP_Ddis_TRRAP --SLKLHTQWLESL-------KNEESLK---FS----------EFNEN------------ ATMa_Spur_ATM -PVKGSHEEWLKAL-------T-VALIK---SGGV------RDEILRL------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK --RRFAQVTMYRQY-------R-TGDLPDIQ-I-K------HSDIIAP------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP N-RDIKFLESLRN-------------------V-K------TFTFLHA------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR -------------------------LISRVSGD-S------ARKIFGV------------ CC1G_00894_Ccin_FRAP T-TKDDWLEWMHRL-------S-VEFMK---ES--------PSHALRA------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------GFSVDSPSFVPS-------PS----------RLGRPSGDVELMYRSEL CC1G_13883_Ccin_PI4K -----IASKYLN------------------------------------------------ CC1G_00331_Ccin_TRRAP -----------RRL-------S-ANTTQQIQRP-L------VQNIVRP------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP N-KLVSFLSDCKN-------------------I-Q------TQQFAMP------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -------------------------LLSQVTGQ--------MASILGA------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------------------------------------------AL-S------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP K-KNEEWRHWLSNL-------S-LTLLQ---CS--------PLKCLRA------------ GK009_Glam_PIKK-Unclassified -------------------------LLI---DG-I-------GR---------------- TRRAP_Hsap_TRRAP ----FV------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----CW------------------------------------------------------ mei-41_Dmel_ATR ----YK------------------------------------------------------ CG2905_Dmel_TRRAP ----TS------------------------------------------------------ CG6535_Dmel_ATM ----FD------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----CW------------------------------------------------------ DNAPK_Mmus_DNAPK ----LQ------------------------------------------------------ ATR_Mmus_ATR ----CS------------------------------------------------------ ATM_Mmus_ATM ----LK------------------------------------------------------ C47D12.1_Cele_TRRAP ----VS------------------------------------------------------ B0261.2_Cele_FRAP ----AS------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ----LA------------------------------------------------------ TEL1_Scer_ATM ----LY------------------------------------------------------ MEC1_Scer_ATR ----MMTLQIKNMAKILKKTPYQLLSPILPVLLRQLGKNLVERKVGFQNLIELLGYSSKT ATM_Hsap_ATM ----LK------------------------------------------------------ ATR_Hsap_ATR ----CS------------------------------------------------------ DNAPK_Hsap_DNAPK ----LQ------------------------------------------------------ TOR_Dmel_FRAP ----CR------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ----FV------------------------------------------------------ smg-1_Cele_SMG1 ----MR------------------------------------------------------ TOR1_Scer_FRAP ----CS------------------------------------------------------ TOR2_Scer_FRAP ----CS------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ----CR------------------------------------------------------ DNAPK_Ddis_DNAPK ----LQ------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----CL------------------------------------------------------ TRRAP_Ddis_TRRAP ----LR------------------------------------------------------ ATMa_Spur_ATM ----LE------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ----LQ------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----VS------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ----FQ------------------------------------------------------ CC1G_00894_Ccin_FRAP ----CM------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K SQEPQT------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ----MQ------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ----LA------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ----CR------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----TR------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----CH------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ---------------------------Q--L---CHI-STTLAE-KTWVQLFPRLWKILS SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ---------------------------A--L---AQA-YNPMAR-DLFNAAFVSCWSELN mei-41_Dmel_ATR ---------------------------P--C---IK-RDSNMLS-TFYPYILLHALLECT CG2905_Dmel_TRRAP ---------------------------Q--L---CHI-DTQLAQ-SVWLSMFPRIWSIFT CG6535_Dmel_ATM ---------------------------K--L---AA-TSFAFAKTCLLPFIK--LLLENS CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ---------------------------A--L---AQA-YNPMAR-DLFNAAFVSCWSELN DNAPK_Mmus_DNAPK ---------------------------A--V---AQK-DPIIAK-QLFSSLFSGILKEMN ATR_Mmus_ATR ---------------------------I--M---MK-HDFKVTI-YLLPHILVYVLLGCN ATM_Mmus_ATM ---------------------------P--M---CE-VKTDFCQ-MLLPYLIHDVLLQDT C47D12.1_Cele_TRRAP ---------------------------QITF---ALN-ENQVTS-KMWVVLFKSFWSSLS B0261.2_Cele_FRAP ---------------------------S--L---GDQ-HPHLAR-DLFPAAFMSVWTELD atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ---------------------------S--I---AHV-DDTRFL-SKLAMRFILTVIHME TEL1_Scer_ATM ---------------------------P--L---CK-GSTAFCE-LVLTDLFFLSTTYDP MEC1_Scer_ATR ILDIFQRYIIPYAIIQYKSDVLSEIAKI--M---CDG-DTSLIN-QMKVNLLK------- ATM_Hsap_ATM ---------------------------P--M---CE-VKTDFCQ-TVLPYLIHDILLQDT ATR_Hsap_ATR ---------------------------I--M---MK-HDFKVTI-YLLPHILVYVLLGCN DNAPK_Hsap_DNAPK ---------------------------A--V---AQR-DPIIAK-QLFSSLFSGILKEMD TOR_Dmel_FRAP ---------------------------S--L---AQE-YDTLLR-DLFNAAFISCWTELS SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ---------------------------Q--L---CHI-STTLAE-KTWVQLFPRLWKILS smg-1_Cele_SMG1 ---------------------------R--RVSRVTE-LLDIQK-DFSAMGALALSADSS TOR1_Scer_FRAP ---------------------------N--L---ASM-YYPLAK-ELFNTAFACVWTELY TOR2_Scer_FRAP ---------------------------S--L---VSV-YYPLAR-ELFNASFSSCWVELQ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ---------------------------G--I---IK-DDLKICH-YLLPLVILNIIEYGR DNAPK_Ddis_DNAPK ---------------------------L--L---CQR-DSTIGV-NVFSSLFTALYKNTP SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ---------------------------S--L---AQD-YHPLVK-ELFNAGFVSCWTELH TRRAP_Ddis_TRRAP ---------------------------E--L---IFI-DSHLVN-DLWCHLFSDMWSDLT ATMa_Spur_ATM ---------------------------P--I---CL-AKVEFAE-RVFPYLIHDILTADN ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ---------------------------A--L---ALR-DSTLSR-LLFSALFRGILARIG FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ---------------------------Q--L---CHS-DTDLTH-SFWVHLFPKVWKILS CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ---------------------------S--V---VRSKDVVLAT-HLLPHLILNILISGE CC1G_00894_Ccin_FRAP ---------------------------T--L---VDI-HQPLAK-ELFNAAFLSCWTELY CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ---------------------------R--L---ITS-FP-------------------- CC1G_00331_Ccin_TRRAP ---------------------------R--L---LFL-DPQVAH-DTWVSVFPAVWSSLS AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ---------------------------Q--L---CHE-STSLAH-HVWINLFPKIWSALP ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ---------------------------G--V---VR-HDMDAAL-YILPYLILDIVCHGS DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ---------------------------G--T---QVN-EPHVAR-ELFAVAFVSCWSQLN SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ---------------------------K--L---ATS-YPRVAR-DLFNYSFLACLSETY GK009_Glam_PIKK-Unclassified ------------------------------------------FL-ALFFAALITDHCKLV TRRAP_Hsap_TRRAP -D---R-Q-QHALAG-EI----------SPFLCS----G--------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -E---D-Q-QDELIR-SI----------ELALTS----Q--------------------- mei-41_Dmel_ATR -T---E-Q-RNHIQE-EF----------MAVLQA----NEESSSSVRGRQELGA-IKENA CG2905_Dmel_TRRAP -E---D-Q-RCNITK-EL----------IPFLSS----G--------------------- CG6535_Dmel_ATM -L---E-H-VESLSQ-ML----------DYFFE----GFT-S--S--------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -E---D-Q-QDELIR-SI----------ELALTS----Q--------------------- DNAPK_Mmus_DNAPK -K---F-K-TTSEKN-II----------TQNLLQ----D--------------------- ATR_Mmus_ATR -Q---E-D-QQEVYA-EI----------MAVLKH----DEQHAISTQD------------ ATM_Mmus_ATM -H---ESW-RTLLSA-HV----------RGFFTSCFKHSSQASRS--------------- C47D12.1_Cele_TRRAP -Q---S-E-IEDFTA-LV----------VPFMSS----G--------------------- B0261.2_Cele_FRAP -S---D-V-QNDLTS-CL----------LRAIS-----T--------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR RD---S-V-TQWILS-TF----------EEALTN----T--------------------- TEL1_Scer_ATM -K-SCL-NWSNRIFT-QI----------AMLL------------HVKD------------ MEC1_Scer_ATR --------------K-NSRQIFAVALVKHGLFSL----D--------------------- ATM_Hsap_ATM -N---ESW-RNLLST-HV----------QGFFTSCLRHFSQTSRS--------------- ATR_Hsap_ATR -Q---E-D-QQEVYA-EI----------MAVLKH----DDQHTINTQD------------ DNAPK_Hsap_DNAPK -K---F-K-TLSEKN-NI----------TQKLLQ----D--------------------- TOR_Dmel_FRAP -P---D-L-KNELTQ-SL----------IQALQV----T--------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -D---R-Q-QHALAG-EI----------SPFLCS----G--------------------- smg-1_Cele_SMG1 -C---K-L-YSDISSTS------------------------------------------- TOR1_Scer_FRAP -S---Q-Y-QEDLIG-SL----------CIALSS----P--------------------- TOR2_Scer_FRAP -T---S-Y-QEDLIQ-AL----------CKALSS----S--------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -E---S-D-IQSIKN-EI----------LEVLNN----NTDLS----------------- DNAPK_Ddis_DNAPK -K---E-S-IRTFQC-NI----------KKLIDS-------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -E---Q-F-QEELVR-SL----------ETALLS----P--------------------- TRRAP_Ddis_TRRAP -K---E-E-QFKLSK-SL----------TLLLSK----D--------------------- ATMa_Spur_ATM -N----VY-RQILSE-QI----------KRVFSAFTESVS-NSRA--------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -D---M-C-TDGETE-LH----------VKGIER----H--------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -E---K-E-QTTLSQ-EV----------SPFLCS----G--------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR -P---D-D-AEDIRT-EI----------RIVLED----QVDPSST--------------- CC1G_00894_Ccin_FRAP -D---Q-Y-QEDLVR-SI----------EFAITS----T--------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K -------------AV-SV----------IPATPT----T--------------------- CC1G_13883_Ccin_PI4K -----------------------------SLMCD----P--------------------- CC1G_00331_Ccin_TRRAP -R---R-E-QADITN-HM----------INLLSK----D--------------------- AqueK043_Aque_ATM ------------------------------VGDFLTESVS-MD----------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -E---Q-H-RQALSG-EV----------SPFLCS----A--------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -Q---E-A-RTGVTD-EI----------LAVLAE----AGTGND---GQPGQPVYL---- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -D---S-Y-KKQLVR-SL----------NYALTS----P--------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -PSNNE-H-RNYIVE-SI----------RSVFLS----Q--------------------- GK009_Glam_PIKK-Unclassified -EH----I-ESHFIS-SL----------YVTS---------------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -----------------------------D----------------I-AEV--------- mei-41_Dmel_ATR FKQFESRKYAAGIKPLASTLVSDRKEDSSR----------------VPRLA--------- CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM -----------------------------TAPNS-----QEI---FRNKRA--------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -----------------------------D----------------I-AEV--------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR --------------------------SASD----------------LCQLS--------- ATM_Mmus_ATM -----------------------------ATPANSDSESENFLRCCLDKKS--------- C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP -----------------------------G-----------------IPEL--------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM -----------------------------------------------SEIK--------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----------------------------TTPANLDSESEHFFRCCLDKKS--------- ATR_Hsap_ATR --------------------------IASD----------------LCQLS--------- DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP -----------------------------D-----------------MPEI--------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -----------------------------L----------------NPPEI--------- TOR2_Scer_FRAP -----------------------------E----------------NPPEI--------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ----------------------------TD----------------NGQIC--------- DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -----------------------------N----------------IPPEI--------- TRRAP_Ddis_TRRAP -----------------------------Y----------------T-KKVPLVSKPIIP ATMa_Spur_ATM -----------------------------PTPMPGSLDQR---NQGLGQRS--------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR --------------------------STHD----------------KKILS--------- CC1G_00894_Ccin_FRAP -----------------------------T----------------APPEL--------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K -----------------------------A----------------------------IP CC1G_13883_Ccin_PI4K -----------------------------R----------------LVFAI--------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM -------------------------------PIP--------------HQS--------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -----------------------NNAFCGS----------------GGEVS--------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -----------------------------N----------------IPSDI--------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -----------------------------N----------------CPLDV--------- GK009_Glam_PIKK-Unclassified ----------------------------------------------VETLY--------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------------------------------TQ------TLLNLA------------ mei-41_Dmel_ATR ----------------------------------GK------LCAELLDFLQRWLREW-Q CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ----------------------------------IK------KFLHIC------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------------------------------TQ------TLLNLA------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ----------------------------------TQ------TVFSVLDHLTQWARHKFQ ATM_Mmus_ATM ----------------------------------QR------TMLAVV------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ----------------------------------IQ------TILNLA------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ----------------------------------LK------MLFNVIKMIRMGSRCK-- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ----------------------------------QR------TMLAVV------------ ATR_Hsap_ATR ----------------------------------TQ------TVFSMLDHLTQWARHKFQ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ----------------------------------TQ------TILNLA------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ---------------------------LIIANL-VN------KMTGVS------------ TOR1_Scer_FRAP ----------------------------------HQ------TLLNLV------------ TOR2_Scer_FRAP ----------------------------------YQ------MLLNLV------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ----------------------------------TQ------IIFHVINSLNNWIDVRKR DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------------------------------LQ------TLLNLA------------ TRRAP_Ddis_TRRAP PTSIPISKPIITTTTSTSSSTSTTTPITTIPLINNS------QLITIV------------ ATMa_Spur_ATM ----------------------------------IK------TLLDTI------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ----------------------------------AQ------AIFTLLDHLNRWAHIMRR CC1G_00894_Ccin_FRAP ----------------------------------IH------RLLNLA------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K PD-------------------------------PDE-------EVDLV------------ CC1G_13883_Ccin_PI4K ----------------------------------LE------VMTLLQ------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ----------------------------------IN------SVINIV------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ----------------------------------MQ------TVFMLLDNLGQWVDDSK- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------------------------------LG------TLLNLA------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------------------------------LQ------ILLDLA------------ GK009_Glam_PIKK-Unclassified -----------------------------------STIPSSDRLT--------------- TRRAP_Hsap_TRRAP -----------SH-Q-V-Q---RDCQPS-------------------A-----LNCF--- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ----------------------------E---------------------------F--- mei-41_Dmel_ATR -RIHG------R------S--TGGKPPE-------------------TI----DSNY--- CG2905_Dmel_TRRAP -----------TN-V-N-Q---KDCHPS-------------------T-----LNTF--- CG6535_Dmel_ATM ----------------------------E---------------------------Y--- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ----------------------------E---------------------------F--- DNAPK_Mmus_DNAPK -----------FNRF-LNT--TFLFFPP-------------------F-----VSCI--- ATR_Mmus_ATR -ALNAEKLAQN-------------KPK--------------------GVSNVNFEDY--- ATM_Mmus_ATM ----------------------------D---------------------------Y--- C47D12.1_Cele_TRRAP -----------VH-NNY-Q---TG-------------------VQDSV-----LAVW--- B0261.2_Cele_FRAP ----------------------------E---------------------------F--- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------N-H-R-RLTNSDRGPAS------------------F-----VFYV--- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR -----------IL----------ETLFL-------------------N-----RA----- ATM_Hsap_ATM ----------------------------D---------------------------Y--- ATR_Hsap_ATR -ALKAEKCPHSK------S--NRNKVDS-------------------MVSTVDYEDY--- DNAPK_Hsap_DNAPK -----------FNRF-LNT--TFSFFPP-------------------F-----VSCI--- TOR_Dmel_FRAP ----------------------------E---------------------------F--- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -----------SH-Q-V-Q---RDCQPS-------------------A-----LNCF--- smg-1_Cele_SMG1 ----------------------------QWKNKLTD------------------TEI--- TOR1_Scer_FRAP ----------------------------E---------------------------F--- TOR2_Scer_FRAP ----------------------------E---------------------------F--- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR KYFLTQQQ---R------T--ASQKGKS--------------------KKLESPPDV--- DNAPK_Ddis_DNAPK --------------I-V-E--RCKFNST-------------------L-----VSSI--- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------------------------E---------------------------F--- TRRAP_Ddis_TRRAP ----------------------------TLTQQQTNPIIVPSLREPNV-----IKTW--- ATMa_Spur_ATM ----------------------------H---------------------------Y--- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -----------LNQM-LTD--SNQFDPA-------------------F-----ISCM--- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----------SH-H-Y-Q---KDAPMS-------------------T-----IHTF--- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR -EITTKQKSETKR-A-R----ASVALGE-------------------S-----QEQL--- CC1G_00894_Ccin_FRAP ----------------------------E---------------------------F--- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K -------------------------------------------------------EQ--- CC1G_13883_Ccin_PI4K ----------------------------K---------------------------ACEN CC1G_00331_Ccin_TRRAP -----------YH-I-K----QSSLRPN-------------------V-----VQSL--- AqueK043_Aque_ATM ----------------------------M---------------------------S--- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -----------AH-L-I-Q---MDCHPS-------------------A-----IGTF--- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -ALTSKGS---R------S--TQAKELS--------------------AKL--LVQC--- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------------------------E---------------------------F--- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------------------------E---------------------------F--- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K EFWDEYNPVYEYHSDRCNITLQLTDIYQVRNEILGQLKQLASTWLKLALDRAPMELHSTL CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ---VE--A-------MSQ----------------------------C-----------VP SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ---ME--H-------SDK-----------------------------------------G mei-41_Dmel_ATR ---RK--I-------H------------------------------------------EF CG2905_Dmel_TRRAP ---VE--S-------LTK----------------------------C-----------AP CG6535_Dmel_ATM ---IR--I-------FNN-----------------------------------------W CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ---ME--H-------SDK-----------------------------------------G DNAPK_Mmus_DNAPK ---QE--I-------SCQ----------------------------H-----------PD ATR_Mmus_ATR ---QS--V-------T------------------------------------------RF ATM_Mmus_ATM ---LR--R-------QKR----------------------------PSSG---TAFDDAF C47D12.1_Cele_TRRAP ---LE--A-------VGD------------------------------------------ B0261.2_Cele_FRAP ---MD--H-------SEK-----------------------------------------G atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ---FD--F-------IYSYSSSEELRKKKKIWEKVISFWKSMMSWTF-----------KD TEL1_Scer_ATM ----ERNC-------L------------------------------------------RI MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ---MR--R-------QKR----------------------------PSSG---TIFNDAF ATR_Hsap_ATR ---QS--V-------T------------------------------------------RF DNAPK_Hsap_DNAPK ---QD--I-------SCQ----------------------------H-----------AA TOR_Dmel_FRAP ---ME--H-------CDR-----------------------------------------D SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ---VE--A-------MSQ----------------------------C-----------VP smg-1_Cele_SMG1 ---F-------------------------------------------------------- TOR1_Scer_FRAP ---ME--H-------DDK------------------------------------------ TOR2_Scer_FRAP ---ME--H-------DDK------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ---VV--I-------E------------------------------------------RF DNAPK_Ddis_DNAPK ---LN--I-------SEK----------------------------N-----------L- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ---ME--L-------HEK------------------------------------------ TRRAP_Ddis_TRRAP ---ME--T-------LGM----------------------------C------------K ATMa_Spur_ATM ---LR--T-------QER----------------------------SSRTSRFTPWDNNF ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ---LE--I-------GFY----------------------------H-----------SE FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ---VE--A-------VSR----------------------------C-----------SP CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ---LR--L-------D------------------------------------------SI CC1G_00894_Ccin_FRAP ---ME--H-------EE------------------------------------------K CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ---LY--G-------AD------------------------------------------Q CC1G_13883_Ccin_PI4K QKYLA----------VNR----------------------------P------------- CC1G_00331_Ccin_TRRAP ---LA--G-------IHR----------------------------C-----------SP AqueK043_Aque_ATM ---LR--K-------MPR----------------------------LR--KGGTAWENNF AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ---LE--A-------VLS----------------------------C-----------KP ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ---EQ--V-------G------------------------------------------QL DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ---ME--R-------DE------------------------------------------D SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ---WE--N-------RSR----------------------------E------------F GK009_Glam_PIKK-Unclassified ----NSNEKDCLAELE------------------------------------------QD TRRAP_Hsap_TRRAP PIPIR----PCVLK--YLG-K--THN-LWFRST--------------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP PLPLRDDNGIVLLG--ERA-A--KCR-AYAKAL--------------------------- mei-41_Dmel_ATR LNLIP----KLLVS--RAS-Y--NCG-EYARAL--------------------------- CG2905_Dmel_TRRAP PIYIP----PNLLA--YLG-K--SHN-LWHRAI--------------------------- CG6535_Dmel_ATM TIPIN----LSNVV--MAS-N--HCQ-AYFLSI--------------------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP PLPLRDDNGIVLLG--ERA-A--KCR-AYAKAL--------------------------- DNAPK_Mmus_DNAPK FLTLD----PASVR--VGC-L--ASL-QQPGGI--------------------------- ATR_Mmus_ATR LDLIP----QDTLA--VAS-F--RSK-AYTRAV--------------------------- ATM_Mmus_ATM WLDLN----YLEVA--KVA-Q--SCS-AHFTAL--------------------------- C47D12.1_Cele_TRRAP AVHLP----SRLIE--FIS-S--KHE-CWHTGI--------------------------- B0261.2_Cele_FRAP PLPIS----HDVLG--RWA-E--QTK-AFAKAC--------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ENGHG----QPLIV--KVA-E--TFG-MEKRCI--------------------------- TEL1_Scer_ATM YSSLD----LQEIC--QIS-L--KIK-EFKFGY--------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM WLDLN----YLEVA--KVA-Q--SCA-AHFTAL--------------------------- ATR_Hsap_ATR LDLIP----QDTLA--VAS-F--RSK-AYTRAV--------------------------- DNAPK_Hsap_DNAPK LLSLD----PAAVS--AGC-L--ASL-QQPVGI--------------------------- TOR_Dmel_FRAP PIPIE----TKLLG--TRA-M--ACR-AYAKAL--------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP PIPMR----PCVLK--YLG-K--THN-LWFRST--------------------------- smg-1_Cele_SMG1 -----D---RNEEG--ND---GDKLA-IC--RK--------------------------- TOR1_Scer_FRAP ALPIP----TQSLG--EYA-E--RCH-AYAKAL--------------------------- TOR2_Scer_FRAP PLPIP----IHTLG--KYA-Q--KCH-AFAKAL--------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR LNGIP----EKILA--FAS-Y--RCG-ALSTSL--------------------------- DNAPK_Ddis_DNAPK EFSPE----FSKIK--DIS-L--NSN-NHPMAI--------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP PLPID----IRTLG--ALA-E--KCH-AYAKAL--------------------------- TRRAP_Ddis_TRRAP PIPKVP---IEVIS--FLG-ENYNCW-YY--AI--------------------------- ATMa_Spur_ATM WLDVD----YLQMA--KAA-Q--MMTNPPARNG--------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK QLTLD----PAAIS--QSC-L--TSR-QLLIGI--------------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP PITIR----PCVLK--YLG-K--SHN-LWHRCI--------------------------- CC1G_00839_Ccin_ATM WLDLD----YYLLA--QSA-V--RCG-AYTTAL--------------------------- CC1G_08126_Ccin_ATR LSNLD----KHLVA--KAA-F--QCK-AYARAL--------------------------- CC1G_00894_Ccin_FRAP PLPIE----HRTLG--EYA-N--KYM-AYAKAL--------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K PLK-F------------------------------------------------------- CC1G_13883_Ccin_PI4K SPSIE----AAELG--A---S--LAE-QFAKAIGPVHRQLVSLTSLSPWPLDGSKTLASQ CC1G_00331_Ccin_TRRAP PMTLP----PHLVK--YLA-K--TFG-CWHIGL--------------------------- AqueK043_Aque_ATM WLDLN----FLDIA--NAA-F--KCC-SYFTSL--------------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP TPHIR----SCLLK--YLG-K--IHN-YWNGSL--------------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR LASIP----KQSLA--SAS-F--RCR-AYARAL--------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP PLPVD----TRTLG--SLA-E--KCH-LFAKAL--------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP STTFS----HNFLG--EVA-E--RCH-AYTRSL--------------------------- GK009_Glam_PIKK-Unclassified EPSMR----DTLIGDVLDLRRFVAMK-QIIELV--------------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K IAVKGYYAGEAAGVRISTSPDKLANPPPQTASASVVESLRRDMSRATREIKGKKSVLTVH CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -----LMLEH---------------QA-F-EKGLSLQ-IK-------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -----HYKEL---------------EF-Q-KGPT-------------------------- mei-41_Dmel_ATR -----SYLES---------------YL-E-EGEDKS------------------------ CG2905_Dmel_TRRAP -----LVLED---------------MA-V-NQSMQS---K-------------------- CG6535_Dmel_ATM -----MYLEL---------------WA-C-SESPKSK-A--------------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -----HYKEL---------------EF-Q-KGPT-------------------------- DNAPK_Mmus_DNAPK -----RLLEE---------------AL-L-RLMPK------------------------- ATR_Mmus_ATR -----MHFES---------------FI-T-EKK--------------------------- ATM_Mmus_ATM -----LYAEI---------------YS-D-KKSTDEQ-EK-------------------- C47D12.1_Cele_TRRAP -----RLLEN---------------HI-W-TIPKQ------------------------- B0261.2_Cele_FRAP -----RYKEM---------------SV-L-KKSGSMQTTFTRKV---------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -----LWLEM---------------FM-E-QKRKT------------------------- TEL1_Scer_ATM -----LLFEE---------------M-----NM--P------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----LYAEI---------------YA-D-KKSMDDQ-EK-------------------- ATR_Hsap_ATR -----MHFES---------------FI-T-EKK--------------------------- DNAPK_Hsap_DNAPK -----RLLEE---------------AL-L-RLLPA------------------------- TOR_Dmel_FRAP -----RYKEE---------------EF-L-LRED-------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -----LMLEH---------------QA-F-EKGLSLP-IK-------------------- smg-1_Cele_SMG1 -----LMHWGRHTKSNRGQSCAAHSEI-I-RLSRKTS----------------------- TOR1_Scer_FRAP -----HYKEI---------------KF-I-KEPE-------------------------- TOR2_Scer_FRAP -----HYKEV---------------EF-L-EEPK-------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -----SYMES---------------LI-R-NETSQIL-KQQQQQHQLNLQLNMQQQNLQY DNAPK_Ddis_DNAPK -----ILCEK---------------LI-L-SLQNT------------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -----HYKES---------------EF-S-QSP--------------------------- TRRAP_Ddis_TRRAP -----RMIEQ---------------QL-I-DRQKLLD----------------------- ATMa_Spur_ATM -----GAIET---------------F--S-QDSQDSA----------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -----RVLEE---------------VL-I-KKSGD------------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----LMLEQ---------------NA-I-TSGFSSH-HR-------------------- CC1G_00839_Ccin_ATM -----LFLEI---------------AP-E-IH---------------------------- CC1G_08126_Ccin_ATR -----MNFEQ---------------QI-H-AL---------------------------- CC1G_00894_Ccin_FRAP -----HYKEM---------------EY-F-AESS-------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K DLRRLLYRGA---------------AVLI-SEKE-------------------------- CC1G_00331_Ccin_TRRAP -----EILGD---------------AL-D-YL---------------------------- AqueK043_Aque_ATM -----LYIEI---------------WC-N-HQGFDAS----------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -----ILLED---------------RA-K-ADGE-LS-MT-------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -----LYYES---------------YV-R-EKSGALN-PA-------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -----HYKEM---------------EF-D-MVLAREQK---------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -----RYKET---------------EY-A-QHPI-------------------------- GK009_Glam_PIKK-Unclassified -----AFQPY---------------RF-SKNSM--------------------------- TRRAP_Hsap_TRRAP ----------PKQT---T-EF-----------YEQESI---------------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ----------DIDGGE-N-QF-----------S--DLD---------------------- CG6535_Dmel_ATM ------------------------------DFL--------------------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ----------EPPTKR-V-RG-----------KT---C---------------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------RS---P-TFEEGSQGTTISSLSEKSK---------------------- C47D12.1_Cele_TRRAP -----------LNNTL-L-RE-----------MKVAPG---------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ---------------------------------STEIE---------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------RS---L-AFEEGSQNTTISSLSEKSK---------------------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ----------ELPAKR-V-RG-----------KA---R---------------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ----------PKQT---T-EF-----------YEQESI---------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR QQQLQQQQPQQQQQQQQQ-QQ----------------QQQVQQQQIPILNSSQPASMASA DNAPK_Ddis_DNAPK ----------TKASTT-N-QA-----------QKLQQ----------------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ----------------------------SLASI----S---------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ----------DERS-R-K-RA-----------RTSRPE---------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----------PRTTSV-Y-DF-----------FEPDNT---------------------- CC1G_00839_Ccin_ATM ----------------------------------DSSK---------------------- CC1G_08126_Ccin_ATR --------------------------------KELDN----------------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --------------------------------KD-DD----------------------- AqueK043_Aque_ATM ----------------------------NLTA---------------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ----------PRDPPP-YDGN-----------YNDELL---------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -------------------------------------------------------ALVS- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -TPPQQ----EILDSLAELYSLLQEEDMWAGLW--QKRCK--Y-S--------------- SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP -----P----AILESLISINNKLQQPEAAAGVL--EYAMKH-FGE--------------- mei-41_Dmel_ATR --QRLL----EQFTFLVEVYGSLRDPDSVEGAV--QVRSY--DMS--------------- CG2905_Dmel_TRRAP -VQQSN----NIFDSLSKMYSSMHEEDLWAGLW--LKFAH--Y-P--------------- CG6535_Dmel_ATM ---DNE----CFQDGAKKAYESIGCLDAIPGFV--NPMR--------------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -----P----AILESLISINNKLQQPEAASGVL--EYAMKH-FGE--------------- DNAPK_Mmus_DNAPK -LPPDV----LRWMELAKLYRSIGEYDVLRGIF--SSELG--TTQ--------------- ATR_Mmus_ATR --QNIQ----KHLGFLQKLYAAMHEPDGVAGVS--AIRKA--EPS--------------- ATM_Mmus_ATM -EETGI----SLQDLLLEIYRSIGEPDSLYGCG--GGKML--QP---------------- C47D12.1_Cele_TRRAP -LAGDI----ETLESLGTLYNEISEFDQFAAIW--ERRAV--F-P--------------- B0261.2_Cele_FRAP --KLEP----NDCQSLITYANKLNVQEEAAGVV--RYAERN-EMN--------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -SETEA----AYYFTLMNLYGRIHELNGVRGAY--ARLSRIQI-D--------------- TEL1_Scer_ATM --NIRE----MNINTLQKIYECINDGDFLAGLP--VPHSI--EGV--------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -EETGI----SLQDLLLEIYRSIGEPDSLYGCG--GGKML--QP---------------- ATR_Hsap_ATR --QNIQ----EHLGFLQKLYAAMHEPDGVAGVS--AIRKA--EPS--------------- DNAPK_Hsap_DNAPK -LPPDV----LRWVELAKLYRSIGEYDVLRGIF--TSEIG--TKQ--------------- TOR_Dmel_FRAP -----S----QVFESLILINNKLQQREAAEGLL--TRYRNA-ANE--------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -TPPQQ----EILDSLAELYSLLQEEDMWAGLW--QKRCK--F-S--------------- smg-1_Cele_SMG1 ---NCE----L---AFFHINSAIR--------G--EKLAA--WQR--------------- TOR1_Scer_FRAP -----N----STIESLISINNQLNQTDAAIGIL--KHAQQH--HS--------------- TOR2_Scer_FRAP -----N----STIEALISINNQLHQTDSAIGIL--KHAQQH--NE--------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR RELALN----NNLQLLQKIYHEMDDIDGLIGLS--HKRVG--SPS--------------- DNAPK_Ddis_DNAPK -QQQLN----QGWDSLRELYKSLKEDDIIMGLI--EKQMGG-DIP--------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -----S----STIEALISINNQLQQPEAAIGIL--IYAQKN--HS--------------- TRRAP_Ddis_TRRAP ---STD----INWDYLSYLYGAIGEKDLLYGIY--RKRYQ--CDE--------------- ATMa_Spur_ATM -MVTGI----NLQTLLMEAFGSIGEPDSVYGCG--AGRLV--DT---------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -SNQEM----STWIELARLYKAMGEFDVLRGIF--GALIK--TKD--------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -AAMQQ----ETLDSLSELYERLEEEDLWAGLW--QRRCK--F-P--------------- CC1G_00839_Ccin_ATM -LD-RK----IVEEIQYEIYAHVDEPDGFYGIQ--TDNLH--R----------------- CC1G_08126_Ccin_ATR -NKNLE----PYYDTIHEIYAHLDQPDGMEGIT--ALIQS---PS--------------- CC1G_00894_Ccin_FRAP -----P----AVIESLISINTKLQQHDAAWGTL--LHAREQ-Y-D--------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -----ATYDRELLHHLVLLPFTVSTPASIAAAV--E------------------------ CC1G_00331_Ccin_TRRAP -PALRD----YVYDSLAEIYAELAEEDMFYGLW--RRRSV---IP--------------- AqueK043_Aque_ATM ----YP----EVQGLLLQVYSQIGEHDGSYGAH--LLFSP--KE---------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -DPFKN----ETMNALSELYALLNEEDMWTGLW--TLRSR--F-P--------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -GTFKD----EDVGFLLKIYGGLDEPDGLLGIA--RLQKR--A-S--------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --HQLV----GAVEALIHVNNQLHQHEAAVGIL--TYAQRN--LG--------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------EAVGRLIAINYSLGYEETAIGTL--RVECKR-LNFISTNLIYDILLRCLY GK009_Glam_PIKK-Unclassified -----------ELLHQIRISDEAIELDVISSFLIKTHFRKY-FEE--------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP TGLDDVFTMMQREGGLEPGAAVNCSAESTLERIINKVVSKIVTKALTEAKKISNLNQSIP GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP QQLVSYGSIGGIFVEGRPVMSGPEGSVLQVDYNEIGIYLSALARRMLKSKLTYQYPTFLM GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------ETA-TAIAYEQHGFFEQA-------QE--------- SMG1_Hsap_SMG1 -----------------------------------TDSSPEV-------IN--------- FRAP_Hsap_FRAP ------------------------LEI-QATWYEKLHEWEDA-------LV--------- mei-41_Dmel_ATR ------------------------VTQ-DILVNRLVERQQDM-------IT--------- CG2905_Dmel_TRRAP ------------------------ETN-IAVSYEQMGFFEEA-------QG--------- CG6535_Dmel_ATM --------------------------S-RLDFLGHGSNLSTI-------LL--------- CG4549_Dmel_SMG1 -----------------------------------SELEPHT-------RQ--------- FRAP_Mmus_FRAP ------------------------LEI-QATWYEKLHEWEDA-------LV--------- DNAPK_Mmus_DNAPK ------------------------DTQ-NALLAEARSDYCQA-------AK--------- ATR_Mmus_ATR ------------------------LKE-QILEHESIGLLRDA-------TA--------- ATM_Mmus_ATM -------------------------LT-RIRTYEHEATWEKA-------LV--------- C47D12.1_Cele_TRRAP ------------------------DTM-RAMSAMQLGDMELA-------QS--------- B0261.2_Cele_FRAP ------------------------FQM-RGRWYEKLNEWEKA-------LG--------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------HVYGKISMREAFGDFNSA-------AC--------- TEL1_Scer_ATM ------------------------LNS-INRI--DSDTWKRFLFNNADFDA--------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -------------------------IT-RLRTYEHEAMWGKA-------LV--------- ATR_Hsap_ATR ------------------------LKE-QILEHESLGLLRDA-------TA--------- DNAPK_Hsap_DNAPK ------------------------ITQ-SALLAEARSDYSEA-------AK--------- TOR_Dmel_FRAP ------------------------LNV-QGRWYEKLHNWDEA-------LE--------- SMG1_Mmus_SMG1 -----------------------------------IDSSPEV-------IS--------- TRRAP_Mmus_TRRAP ------------------------ETA-TAIAYEQHGFFEQA-------QE--------- smg-1_Cele_SMG1 ------------------------L-E-VE-RQRLKLVKTQN-------LD--------- TOR1_Scer_FRAP ------------------------LQL-KETWFEKLERWEDA-------LH--------- TOR2_Scer_FRAP ------------------------LQL-KETWYEKLQRWEDA-------LA--------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------NEE-KIVELESQGFWGDA-------LL--------- DNAPK_Ddis_DNAPK ------------------------YTK-KALEFELKGDWVNV-------LK--------- SMG1_Ddis_SMG1 -----------------------------------LESNSIS-------FP--------- Tor_Ddis_FRAP ------------------------VEL-KEGWYEKLRRWEDA-------LA--------- TRRAP_Ddis_TRRAP ------------------------T-K-LGLLLEQFYMFQSS-------QE--------- ATMa_Spur_ATM -------------------------NA-RIHTYEHEGEWGKA-------LA--------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------VTQ-EAIQAESRGDYESA-------LE--------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------ETA-TALSYEQQGFFEQA-------QT--------- CC1G_00839_Ccin_ATM --------------------------F-LIERFRHEKQWDKA-------FR--------- CC1G_08126_Ccin_ATR ------------------------LEH-QIREHESIGQWTSA-------QS--------- CC1G_00894_Ccin_FRAP ------------------------VTK-HEEWYERLGRWQEA-------LQ--------- CC1G_06302_Ccin_PI3K -----------------------------------D------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K --------------VWTWLIAENPHIE-VALMGELVAAWTDT-------IV--------- CC1G_00331_Ccin_TRRAP ------------------------DTN-VGLAFEQVGMWEQA-------SS--------- AqueK043_Aque_ATM -------------------------EF-TRKLDEHEGRWEEL-------LT--------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------ETR-VAIAYECQGLYSQA-------QE--------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------LED-QVLINKISGNWAEA-------LT--------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------VQL-KESWQ----VFAV------------------- SMG1_Smoe_SMG1 -----------------------------------SVLGADG-------VQ--------- GK008_Glam_FRAP YEENLFQSVLKTLRYKAQGHMQDLYGP-SPKWFENVCLWDKA-------LS--------- GK009_Glam_PIKK-Unclassified ------------------------QEA-ASSWQTLV--------------AELSPEVDRT TRRAP_Hsap_TRRAP SYEKAM-DKA-KK-----------EHERSNASPAI------------------------F SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP AYDKKM-DTN-KD----------------------------------------------- mei-41_Dmel_ATR SYEQLL-SSTDQM-----------QPD--------------------------------- CG2905_Dmel_TRRAP AYDLAM-TKF-KQ-----------DLSNGVVNTYV------------------------N CG6535_Dmel_ATM ESDHLD-RAS-GQ-----------L-C--------------------------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP AYDKKM-DTN-KE----------------------------------------------- DNAPK_Mmus_DNAPK LYDEAL-NKL-EW-----------VD-----GEPT------------------------E ATR_Mmus_ATR CYDRAI-QLE-PD-----------QII--------------------------------- ATM_Mmus_ATM TYDLET-SIS-SS-------------T--------------------------------- C47D12.1_Cele_TRRAP YLEKSM-SST-YETLAPTINPNNTSNSEKHVSPII------------------------D B0261.2_Cele_FRAP AYELEE-KKK-SS-----------C---------PNLQVYDEKDHLMTPEE--------A atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -FARMTGKGK-PF-----------N-STEA------------------------------ TEL1_Scer_ATM NYTTSL-EEEK------------------------------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM TYDLET-AIP-SS-------------T--------------------------------- ATR_Hsap_ATR CYDRAI-QLE-PD-----------QII--------------------------------- DNAPK_Hsap_DNAPK QYDEAL-NKQ-DW-----------VD-----GEPT------------------------E TOR_Dmel_FRAP HYERNL-KTD-SS----------------------------------------------- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP SYEKAM-DKA-KK-----------EHERSNASPAI------------------------F smg-1_Cele_SMG1 VRIREM-N---------------------------------------------------- TOR1_Scer_FRAP AYNERE-KAG-DT----------------------------------------------- TOR2_Scer_FRAP AYNEKE-AAG-ED----------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR YYNTAL-ERS-PI-----------NMD--------------------------------- DNAPK_Ddis_DNAPK VYDEAT-SKL-ES-----------GELNQYQGNLS------------------------E SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP AYEKKQ-KDD-PN-----------G----------------------------------- TRRAP_Ddis_TRRAP VFLSAM-NKY-SA-----------V---G-CKPTP------------------------R ATMa_Spur_ATM AYDLQM-QSS-SS-----------E-A--------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK LYSKAI-SSD-W------------GP-----DGVA------------------------R FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP TYEQAL-AKA-RS-----------EHNSGPASNML------------------------F CC1G_00839_Ccin_ATM FHGAAL-EAG-SE-----------GAGVGNVEGIA------------------------Q CC1G_08126_Ccin_ATR CWEVRL-QES-PD-----------NLE--------------------------------- CC1G_00894_Ccin_FRAP VYDRKA-MED-PD----------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP VYEAAQ-TKV-KA-----------GNL-----PFN------------------------E AqueK043_Aque_ATM YSNWEG-MLT-GK-----------C----------------------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP HYEKAM-SRA-RE-----------LHNVGPAPPSM------------------------I ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR FCEQAL-ELE-PK-----------SLY--------------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------ATH-------------------------------------------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP GYNRQI-DQL-KL-----------S---------LK--------------SNTSEARTLL GK009_Glam_PIKK-Unclassified LYMSRL-DSS-FE---DSMSLTRTA----------------------------------- TRRAP_Hsap_TRRAP PEYQLWEDHWI----------RCSK----------------------------------- SMG1_Hsap_SMG1 ----YLGNKAC----------ECYI----------------------------------- FRAP_Hsap_FRAP --DPELMLGRM----------RCLE----------------------------------- mei-41_Dmel_ATR -----HVRAMIDAYLRDTPKTAQLI----------------------------------- CG2905_Dmel_TRRAP SELLLWENHWM----------RCAK----------------------------------- CG6535_Dmel_ATM ----------I----------DIMK----------------------------------- CG4549_Dmel_SMG1 ----FVVSQMM----------QCLQ----------------------------------- FRAP_Mmus_FRAP --DPELMLGRM----------RCLE----------------------------------- DNAPK_Mmus_DNAPK AEKEFWELASL----------DCYN----------------------------------- ATR_Mmus_ATR -----HYHGVV----------KSML----------------------------------- ATM_Mmus_ATM -----RQSGII----------QALQ----------------------------------- C47D12.1_Cele_TRRAP KEYDHWMEMYI----------TNCS----------------------------------- B0261.2_Cele_FRAP ATAEEARMHEM----------RCLE----------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ---IQKLIDEL----------NCL------------------------------------ TEL1_Scer_ATM -------ESLI----------KATE----------------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----RQAGII----------QALQ----------------------------------- ATR_Hsap_ATR -----HYHGVV----------KSML----------------------------------- DNAPK_Hsap_DNAPK AEKDFWELASL----------DCYN----------------------------------- TOR_Dmel_FRAP --DLEARLGHM----------RCLE----------------------------------- SMG1_Mmus_SMG1 ----YLGNKAC----------ECYI----------------------------------- TRRAP_Mmus_TRRAP PEYQLWEDHWI----------RCSK----------------------------------- smg-1_Cele_SMG1 ------------------------E----------------------------------- TOR1_Scer_FRAP --SVSVTLGKM----------RSLH----------------------------------- TOR2_Scer_FRAP --SVEVMMGKL----------RSLY----------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -----LRIGAL----------NCLF----------------------------------- DNAPK_Ddis_DNAPK SETALWENGRL----------ECFT----------------------------------- SMG1_Ddis_SMG1 ----FVLEQII----------KSYL----------------------------------- Tor_Ddis_FRAP -GTIENTMGIL----------RCLH----------------------------------- TRRAP_Ddis_TRRAP SENLLWEDHWL----------ECAK----------------------------------- ATMa_Spur_ATM -----TQLGLL----------KAMQ----------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK EEEDFWDEARL----------QCCN----------------------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP PEYHLWESHWV----------RCCK----------------------------------- CC1G_00839_Ccin_ATM ----------------------SFH----------------------------------- CC1G_08126_Ccin_ATR -----YHQGLL----------RCLR----------------------------------- CC1G_00894_Ccin_FRAP --SPEVKIGRV----------KCYH----------------------------------- CC1G_06302_Ccin_PI3K ----ELLGYLL----------QL------------------------------------- CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ---------HQ----------RGIF----------------------------------- CC1G_00331_Ccin_TRRAP LEYCLWEDHWV----------LATE----------------------------------- AqueK043_Aque_ATM -----NE-LLD----------KGCK----------------------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP PEYKLWEEHWC----------KCSR----------------------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -----WQSGIL----------DCLV----------------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ILQKIMVVGRM----------RCLV----------------------------------- SMG1_Smoe_SMG1 ----FIIGRIV----------ESYV----------------------------------- GK008_Glam_FRAP PMLVNLTKDKI----------RCLF----------------------------------- GK009_Glam_PIKK-Unclassified ------------------------PKTAQKPSVDYLTFLSGHSMLVGNPLRAIMIAGVYW TRRAP_Hsap_TRRAP ----------------------------------------------ELNQWE---ALTEY SMG1_Hsap_SMG1 ----------------------------------------------SIADWA---AVQEW FRAP_Hsap_FRAP ----------------------------------------------ALGEWG---QLHQQ mei-41_Dmel_ATR ----------------------------------------------ADGLWQ---RLSD- CG2905_Dmel_TRRAP ----------------------------------------------ELNQWD---ILLDY CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ----------------------------------------------DLGQWS---QLVEL FRAP_Mmus_FRAP ----------------------------------------------ALGEWG---QLHQQ DNAPK_Mmus_DNAPK ----------------------------------------------NLSKWK---ELEYC ATR_Mmus_ATR ----------------------------------------------GLGQLS---TVITQ ATM_Mmus_ATM ----------------------------------------------NLGLSH---ILSVY C47D12.1_Cele_TRRAP ----------------------------------------------ELLQWQ---NV--- B0261.2_Cele_FRAP ----------------------------------------------ALGRWD---ELNSK atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------EYSQ---IER-- TEL1_Scer_ATM ----------------------------------------------DSGFYGLTSLLESR MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ----------------------------------------------NLGLCH---ILSVY ATR_Hsap_ATR ----------------------------------------------GLGQLS---TVITQ DNAPK_Hsap_DNAPK ----------------------------------------------HLAEWK---SLEYC TOR_Dmel_FRAP ----------------------------------------------ALGDWS---ELSNV SMG1_Mmus_SMG1 ----------------------------------------------SIADWA---AVQEW TRRAP_Mmus_TRRAP ----------------------------------------------ELNQWE---ALTEF smg-1_Cele_SMG1 ----------------------------------------------VFGSLA---EV--- TOR1_Scer_FRAP ----------------------------------------------ALGEWE---QLSQL TOR2_Scer_FRAP ----------------------------------------------ALGEWE---ELSKL TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ----------------------------------------------NLGQHE---SLLLQ DNAPK_Ddis_DNAPK ----------------------------------------------KLCNWS---ALKDN SMG1_Ddis_SMG1 ----------------------------------------------DISNFT---EVEQF Tor_Ddis_FRAP ----------------------------------------------ALGEWE---RLSAL TRRAP_Ddis_TRRAP ----------------------------------------------RLNQWN---FVHEF ATMa_Spur_ATM ----------------------------------------------NFGLSG---ILQTY ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ----------------------------------------------QLTKWD---DMESF FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----------------------------------------------ELSQWD---ILMEY CC1G_00839_Ccin_ATM ----------------------------------------------SFGFNH---LAIGT CC1G_08126_Ccin_ATR ----------------------------------------------NLGHYD---TLRNH CC1G_00894_Ccin_FRAP ----------------------------------------------ALGEWE---LLAAQ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ----------------------------------------------GA------------ CC1G_00331_Ccin_TRRAP ----------------------------------------------KLQHWD---ILYDF AqueK043_Aque_ATM ----------------------------------------------SLAYYH---MLDVY AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ----------------------------------------------ELCKWD---VLNDF ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ----------------------------------------------NMGHFQ---AMVTH DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------------------------------------------ALARWE---ELSTL SMG1_Smoe_SMG1 ----------------------------------------------SLSDWE---ALEGW GK008_Glam_FRAP ----------------------------------------------ALADYS---AVQEE GK009_Glam_PIKK-Unclassified AANEVTYKGVFVDILQYISRSYATVFSICFLKVFRPDAFFSILTLLAEGATD---HLSTI TRRAP_Hsap_TRRAP GQS--------------------------KGH------------I--------------N SMG1_Hsap_SMG1 QNA-IHD-L-------------KKS----------------------------------T FRAP_Hsap_FRAP CCE-KWT-L-------------VNDE---TQA------------K--------------M mei-41_Dmel_ATR ------------------------RY---SDQ------------C--------------F CG2905_Dmel_TRRAP AQT--------------------------NKD------------K--------------N CG6535_Dmel_ATM GNG-LWS-F-------------AKLQ---QH-------------Q--------------N CG4549_Dmel_SMG1 KQQ-QMT-R-------------PED------R------------E--------------L FRAP_Mmus_FRAP CCE-KWT-L-------------VNDE---TQA------------K--------------M DNAPK_Mmus_DNAPK STV-NIVS---------------------------------------------------E ATR_Mmus_ATR VNG-VHA-N--------------RSE---WTD------------E--------------L ATM_Mmus_ATM LKG-LDY-E-----------R---RE---WCA------------E--------------L C47D12.1_Cele_TRRAP -----------------------ADVCNGKDM------------Q--------------H B0261.2_Cele_FRAP SVV--WA-DQRGNRNDSVRDEINKKQ---LDH------------K--------------M atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -NE--------------------------QED------------Y--------------L TEL1_Scer_ATM LSG-S------------------------------------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM LKG-LDY-E-----------N---KD---WCP------------E--------------L ATR_Hsap_ATR VNG-VHA-N--------------RSE---WTD------------E--------------L DNAPK_Hsap_DNAPK STA-SIDS---------------------------------------------------E TOR_Dmel_FRAP TKH-EWE-N-------------FGTE---AKS------------R--------------A SMG1_Mmus_SMG1 QNA-VHD-L-------------KKN----------------------------------S TRRAP_Mmus_TRRAP GQS--------------------------KGH------------I--------------N smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP AAR-KWK-V-------------SKLQ---TKK------------L--------------I TOR2_Scer_FRAP ASE-KWG-T-------------AKPE---VKK------------A--------------M TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR IEG-LKQ-E-----------PWLTNK---DQS------------K--------------L DNAPK_Ddis_DNAPK FNS-YYPNP--------------NQI---FKE------------K--------------N SMG1_Ddis_SMG1 LQNYQNQ-I-------------QQQ----------------------------------- Tor_Ddis_FRAP SSE-TWK-S-----------D-INDH---TRA------------T--------------I TRRAP_Ddis_TRRAP SKE----------------------------K------------N--------------M ATMa_Spur_ATM LAG-QKA-Q-----------G-QQCE---GDQ------------A--------------L ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK STD-QIEG---------------------------------------------------K FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP GNT--------------------------KGH------------T--------------N CC1G_00839_Ccin_ATM LQT-----S-----------E--ETF--GSRN------------L--------------S CC1G_08126_Ccin_ATR VKG-ILT-S--------------HPE---WQA------------D--------------V CC1G_00894_Ccin_FRAP VQE-NWA-N-------------ATNE---ERR------------E--------------M CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP AKS----------------------------E------------G--------------N AqueK043_Aque_ATM K---------------------KE-T---SDS------------T--------------S AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP GKA--------------------------HGG------------T--------------N ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR VDG-LLA-R--------------LRD---SRR------------E--------------W DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP CRE-TWS-E---------------PS---AQL------------Q--------------M SMG1_Smoe_SMG1 LQE-LQV-L-------------RAKH---AGK------------S--------------Y GK008_Glam_FRAP ADQ-LLN-Y-------------LSSE---SKE------------EAGLTTVKHTLIKGFQ GK009_Glam_PIKK-Unclassified AT-----------------------------ERKNAVMVLRTGVI--------------- TRRAP_Hsap_TRRAP PYLV------------------------------------------------L------- SMG1_Hsap_SMG1 SSTS------------------------------------------------LNLKADFN FRAP_Hsap_FRAP ARMA------------------------------------------------A------- mei-41_Dmel_ATR AECK------------------------------------------------S------- CG2905_Dmel_TRRAP MFLI------------------------------------------------L------- CG6535_Dmel_ATM IEPD------------------------------------------------Y------- CG4549_Dmel_SMG1 NPFL------------------------------------------------QRSNVEVN FRAP_Mmus_FRAP ARMA------------------------------------------------A------- DNAPK_Mmus_DNAPK NSLD------------------------------------------------L------- ATR_Mmus_ATR NTYR------------------------------------------------V------- ATM_Mmus_ATM QELR------------------------------------------------Y------- C47D12.1_Cele_TRRAP VRGL------------------------------------------------I------- B0261.2_Cele_FRAP AVIA------------------------------------------------A------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR NSL--------------------------------------------------------- TEL1_Scer_ATM ---S------------------------------------------------D------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM EELH------------------------------------------------Y------- ATR_Hsap_ATR NTYR------------------------------------------------V------- DNAPK_Hsap_DNAPK NPPD------------------------------------------------L------- TOR_Dmel_FRAP GPLA------------------------------------------------A------- SMG1_Mmus_SMG1 SSTS------------------------------------------------LNLKADFN TRRAP_Mmus_TRRAP PYLV------------------------------------------------L------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP APLA------------------------------------------------A------- TOR2_Scer_FRAP APL-------------------------------------------------A------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR GTIK------------------------------------------------I------- DNAPK_Ddis_DNAPK CDLL------------------------------------------------L------- SMG1_Ddis_SMG1 -SNS------------------------------------------------LIIYKD-T Tor_Ddis_FRAP APLA------------------------------------------------A------- TRRAP_Ddis_TRRAP YDLT------------------------------------------------I------- ATMa_Spur_ATM LEYQ------------------------------------------------Y------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK GSND------------------------------------------------L------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP PQLV------------------------------------------------L------- CC1G_00839_Ccin_ATM PGLA------------------------------------------------Y------- CC1G_08126_Ccin_ATR IDFH------------------------------------------------T------- CC1G_00894_Ccin_FRAP APMA------------------------------------------------A------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP QELM------------------------------------------------L------- AqueK043_Aque_ATM QQCY------------------------------------------------T------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP PFLV------------------------------------------------L------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR YMRG------------------------------------------------V------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP APMA------------------------------------------------A------- SMG1_Smoe_SMG1 TGAL------------------------------------------------TTAGIDMN GK008_Glam_FRAP ADIA------------------------------------------------T------- GK009_Glam_PIKK-Unclassified -NKLIAGSAEQQKLIYNQDINDTSSNAQLVDRFYGISYTLLGSLYAAVSSYPL------- TRRAP_Hsap_TRRAP -------------------ECAW--------------RV-------------------SN SMG1_Hsap_SMG1 YIKSL------SSFESGKFVECTEQL-------ELL--P-------------------GE FRAP_Hsap_FRAP -------------------AAAW------------G--L-------------------GQ mei-41_Dmel_ATR -------------------ELLW--------------RL-------------------GS CG2905_Dmel_TRRAP -------------------ESSW--------------RV-------------------PD CG6535_Dmel_ATM -------------------EIFW------------R--L-------------------GQ CG4549_Dmel_SMG1 ALERLLAKSEESCSSMDALGGVFQQL-------SLW--P-------------------SN FRAP_Mmus_FRAP -------------------AAAW------------G--L-------------------GQ DNAPK_Mmus_DNAPK -------------------SKMW--------------SEPFYQETYLPYVIRSKLKLLLQ ATR_Mmus_ATR -------------------EAAW--------------KL-------------------SQ ATM_Mmus_ATM -------------------QAAW------------R--N-------------------MQ C47D12.1_Cele_TRRAP -------------------NAAS--------------HI-------------------PD B0261.2_Cele_FRAP -------------------RGAW------------A--V-------------------DN atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ----------------------K--------------TL-------------------SQ TEL1_Scer_ATM -------------------VYKW------------NLEL-------------------GD MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -------------------QAAW------------R--N-------------------MQ ATR_Hsap_ATR -------------------EAAW--------------KL-------------------SQ DNAPK_Hsap_DNAPK -------------------NKIW--------------SEPFYQETYLPYMIRSKLKLLLQ TOR_Dmel_FRAP -------------------VAAW------------G--L-------------------QD SMG1_Mmus_SMG1 YIKSL------SSFESGEFVECTEQL-------ELL--P-------------------GE TRRAP_Mmus_TRRAP -------------------ECAW--------------RV-------------------SN smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -------------------GAAW------------G--L-------------------GE TOR2_Scer_FRAP -------------------AAAW------------G--L-------------------EQ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -------------------QSSW--------------RL-------------------SH DNAPK_Ddis_DNAPK -------------------SYFF--------------E--------------FNLKVKEN SMG1_Ddis_SMG1 FIKTL------GSFYRGEMEEAHAFAKRTESQNHIL--Q-------------------RE Tor_Ddis_FRAP -------------------AAAW------------N--L-------------------VN TRRAP_Ddis_TRRAP -------------------ESAW------------K--I-------------------PQ ATMa_Spur_ATM -------------------EAAW------------R--N-------------------GL ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -------------------SQIW--------------NDDYQQEIYLPYMMRSKLKRLME FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------------ESAW--------------RV-------------------PN CC1G_00839_Ccin_ATM -------------------QLGW--------------RS-------------------AT CC1G_08126_Ccin_ATR -------------------ETLL--------------MV-------------------GA CC1G_00894_Ccin_FRAP -------------------AAAW------------S--L-------------------ND CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -------------------ESAW--------------RT-------------------LE AqueK043_Aque_ATM -------------------ENIW------------R--L-------------------TQ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -------------------ENAW--------------RV-------------------QD ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -------------------QAAW--------------RL-------------------GQ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------------------SAAW------------N--M-------------------GE SMG1_Smoe_SMG1 SIHAL------SRFDASDMEGTWGYL-------DLT--P-------------------QS GK008_Glam_FRAP -------------------YAAW------------S--L-------------------LE GK009_Glam_PIKK-Unclassified -------------------HDSF--------------SI-------------------PQ TRRAP_Hsap_TRRAP W---TA--MKE----------------ALVQ--VEVSC-----PK-----------EMA- SMG1_Hsap_SMG1 N---IN----LLAGGSKEKIDMKKLLPNMLS--P-DPR------E-------------LQ FRAP_Hsap_FRAP W---DS--MEE----------------YTCM--IPRD---------------------T- mei-41_Dmel_ATR Y---DE--MEE----------------LQSN--W---------PA-----------QC-- CG2905_Dmel_TRRAP W---NL--MKI----------------ALAK--TEQCY-----LK-----------HYG- CG6535_Dmel_ATM W---DS--LTD----------------PKHQ--QNQTVVRTSLDL-----------EQE- CG4549_Dmel_SMG1 W---DE--S-V------------------------------------------------- FRAP_Mmus_FRAP W---DS--MEE----------------YTCM--IPRD---------------------T- DNAPK_Mmus_DNAPK GEGNQS--LLT----------------------FV-----DEAMN-----------KEL- ATR_Mmus_ATR W---DL--VEN----------------YLAA--D---------GK-----------STT- ATM_Mmus_ATM W---GL--CAS----------------AGQE--VEGT---------------------S- C47D12.1_Cele_TRRAP W---NV--VEE----------------CKSQ--IAGCI-----PP-----------SFH- B0261.2_Cele_FRAP W---ER--MAD----------------YVSV--ISEN---------------------T- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR W---VN--IDN----------------DIGP--SPHIF-----SR-----------NIE- TEL1_Scer_ATM W---KL--LTP----------------KVVD---------------------------S- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM W---DH--CTS----------------VSKE--VEGT---------------------S- ATR_Hsap_ATR W---DL--VEN----------------YLAA--D---------GK-----------STT- DNAPK_Hsap_DNAPK GEADQS--LLT----------------------FI-----DKAMH-----------GEL- TOR_Dmel_FRAP W---EA--MRE----------------YVRC--IPED---------------------T- SMG1_Mmus_SMG1 N---IN----LLAGGSKEKIDMKKLLPNMLS--P-DPR------E-------------LQ TRRAP_Mmus_TRRAP W---TA--MKE----------------ALVQ--VEVSC-----PK-----------EMA- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP W---DM--LEQ----------------YISV--MKPK---------------------S- TOR2_Scer_FRAP W---DE--IAQ----------------YTSV--MKSQ---------------------S- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR W---DK--IDE----------------TLSQ--T----------H-----------EPN- DNAPK_Ddis_DNAPK W---NY--LYQ----------------------FI-----ADLAN-----------T-K- SMG1_Ddis_SMG1 Q---LG----L------------------------------------------------- Tor_Ddis_FRAP W---DK--MDE----------------YVCA--MNKD---------------------T- TRRAP_Ddis_TRRAP W---NS--VKE----------------NMKK--MMSQG------D-------------T- ATMa_Spur_ATM W---DL--DLE----------------SSV-EG--SK---------------------G- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK GSEDDS--LLG----------------------FI-----DSSAK-----------DQE- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP W---GA--MKE----------------ALAQ--VEQSC-----PR-----------EMN- CC1G_00839_Ccin_ATM W---DL--PES----------------DTYT----------------------------- CC1G_08126_Ccin_ATR W---DD--VEA----------------LV-----------NTA-D-----------STS- CC1G_00894_Ccin_FRAP W---DS--MDN----------------YIGT--MKND---------------------S- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP W---AG--HKE----------------ELDE--QI-----AQLPD-----------VAT- AqueK043_Aque_ATM W---RD--TDD----------------MNLLHVGTTD---------------------N- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP W---SA--MRE----------------ASTQ--AEPIC-----SE-----------SYS- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR W---DL--INE----------------YVHG--SELEA--GSTES-----------DSA- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP W---DE--MEE----------------YVSQ--MDNGD------EMNVPTRGQDGTGTG- SMG1_Smoe_SMG1 N--------------------------NEIT--I-DPR------Q-------------AL GK008_Glam_FRAP Q---DQEDVEI----------------WLRV--LPED---------------------N- GK009_Glam_PIKK-Unclassified W---RL--HNN----------------VIN------------------------------ TRRAP_Hsap_TRRAP --WK---VNMYR---GYLAI---------------------------------------- SMG1_Hsap_SMG1 KSIE---VQLLR---S-SVCLATALNPIEQDQ---------------------------- FRAP_Hsap_FRAP --HD---GAFYR---AVLAL---------------------------------------- mei-41_Dmel_ATR ----------SQ---GCLKL---------------------------------------- CG2905_Dmel_TRRAP --FK---INLYK---GYLSI---------------------------------------- CG6535_Dmel_ATM --FK---RHHFV---ALRSI---------------------------------------- CG4549_Dmel_SMG1 ----------------------------------------------------------SS FRAP_Mmus_FRAP --HD---GAFYR---AVLAL---------------------------------------- DNAPK_Mmus_DNAPK --QKTVLELQYSQELSLLYI---------------------------------------- ATR_Mmus_ATR --WS---VRLGQ---LLLSA---------------------------------------- ATM_Mmus_ATM --YH---ESLYN---ALQCL---------------------------------------- C47D12.1_Cele_TRRAP --LD---YTLFN---LMSTV---------------------------------------- B0261.2_Cele_FRAP --QD---GAMLR---AVVAV---------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR --YW---ATE-S---TILKM---------------------------------------- TEL1_Scer_ATM --KA---KGLYY---AIKNL---------------------------------------- MEC1_Scer_ATR -------PTFDK---GYITA---------------------------------------- ATM_Hsap_ATM --YH---ESLYN---ALQSL---------------------------------------- ATR_Hsap_ATR --WS---VRLGQ---LLLSA---------------------------------------- DNAPK_Hsap_DNAPK --QKAILELHYSQELSLLYL---------------------------------------- TOR_Dmel_FRAP --QD---GSYYR---AVLAV---------------------------------------- SMG1_Mmus_SMG1 KSIE---VQLLR---S-SVFLATALNHMEQDQ---------------------------- TRRAP_Mmus_TRRAP --WK---VNMYR---GYLAI---------------------------------------- smg-1_Cele_SMG1 ----------FT---TSCQL---------------------------------------- TOR1_Scer_FRAP --PD---KEFFD---AILYL---------------------------------------- TOR2_Scer_FRAP --PD---KEFYD---AILCL---------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR --FE---AYLGR---ILYSL---------------------------------------- DNAPK_Ddis_DNAPK --QYQYLENKFPGELAFLEV---------------------------------------- SMG1_Ddis_SMG1 ---------------------GLLGNQIMTDELLLSIMVNQKDLFNNTNIINNNNSGGSS Tor_Ddis_FRAP --VE---GSFYR---AILEV---------------------------------------- TRRAP_Ddis_TRRAP --SI---RKILQ---GYFLT---------------------------------------- ATMa_Spur_ATM --YH---ENVFR---ALCSE---------------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK --KRVILESRYTEELAALSI---------------------------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --WK---VNLYR---GFIAI---------------------------------------- CC1G_00839_Ccin_ATM --PG---ASLYH---VLRCL---------------------------------------- CC1G_08126_Ccin_ATR --VP---VMMAK---VMLAM---------------------------------------- CC1G_00894_Ccin_FRAP --PD---RAFYR---AILSV---------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --PR---RRVFE---AFIAL---------------------------------------- AqueK043_Aque_ATM --YH---PCLHN---LLLTL---------------------------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP --AR---LNLLR---GFLAL---------------------------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR --FD---LSLAK---VLQTL---------------------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --FA---GAFFR---AVLCI---------------------------------------- SMG1_Smoe_SMG1 QRSE---QMLLQ---A-MLR---------------------------------------- GK008_Glam_FRAP --ID---GTIIR---ATSYI---------------------------------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------C--HPEEQQ-----L--------------- SMG1_Hsap_SMG1 -------------------------------KWQSI--------T--------------- FRAP_Hsap_FRAP ------------------------------H--QDL--------F--------------- mei-41_Dmel_ATR ------------------------------R--RPLTT------R--------------- CG2905_Dmel_TRRAP ------------------------------L--HQEERQ-----T--------------- CG6535_Dmel_ATM ------------------------------G--QRE--------E--------------- CG4549_Dmel_SMG1 SGLSERASFS-------------------------------------------------- FRAP_Mmus_FRAP ------------------------------H--QDL--------F--------------- DNAPK_Mmus_DNAPK ------------------------------L--QDD--------I--------------- ATR_Mmus_ATR ------------------------------K--KRD--------T--------------- ATM_Mmus_ATM ------------------------------R--NRE--------F--------------- C47D12.1_Cele_TRRAP ------------------------------M--RMNENSSPTHMK--------------- B0261.2_Cele_FRAP ------------------------------H--NDE--------N--------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------I--RNDER------D--------------- TEL1_Scer_ATM ------------------------------P--QD---------V--------------- MEC1_Scer_ATR ------------------------------Y--LPD------------------------ ATM_Hsap_ATM ------------------------------R--DRE--------F--------------- ATR_Hsap_ATR ------------------------------K--KRD--------I--------------- DNAPK_Hsap_DNAPK ------------------------------L--QDD--------V--------------- TOR_Dmel_FRAP ------------------------------H--HDD--------F--------------- SMG1_Mmus_SMG1 -------------------------------KWQSL--------T--------------- TRRAP_Mmus_TRRAP ------------------------------C--HPEEQQ-----L--------------- smg-1_Cele_SMG1 ---------------------------------KSD--------F--------------- TOR1_Scer_FRAP ------------------------------H--KND--------Y--------------- TOR2_Scer_FRAP ------------------------------H--RNN--------F--------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------V--KKQ--------E--------------- DNAPK_Ddis_DNAPK ------------------------------T--RSD--------H--------------- SMG1_Ddis_SMG1 SGTATATAVTTTTTTTTTTTTTTTTTTNTNNDIIGF--------S--------------- Tor_Ddis_FRAP ------------------------------H--HDN--------F--------------- TRRAP_Ddis_TRRAP ------------------------------N--EKR--------Y--------------- ATMa_Spur_ATM ------------------------------R--HR------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------L--KED--------Y--------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------C--HPDEKN-----L--------------- CC1G_00839_Ccin_ATM ------------------------------H--R--EMD-----L--------------- CC1G_08126_Ccin_ATR ------------------------------R--KGD--------P--------------- CC1G_00894_Ccin_FRAP ------------------------------H--QNQ--------F--------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ----------------------------------ML--------DYSPTNKETIDRASSH CC1G_00331_Ccin_TRRAP ------------------------------L--KQP------------------------ AqueK043_Aque_ATM ------------------------------K--HNK--------K--------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------C--YPDEQR-----L--------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------R--SKD--------Q--------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------R--RSK--------Y--------------- SMG1_Smoe_SMG1 ------------------------------K--DSE--------V--------------- GK008_Glam_FRAP ------------------------------K--ANK--------M--------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP SFIE------RLVEMA---SSLA--IREWRRLP---HVVSH------------------- SMG1_Hsap_SMG1 ENVV------KYLKQT---SRIA--IGPLR---LSTL-TVS------------------- FRAP_Hsap_FRAP SLAQ------QCIDKA---RDLL--DAELT---AMAGESYS------------------- mei-41_Dmel_ATR IEFD------SLLDGM---RESV--LEELRSCSAVQQHSYA------------------- CG2905_Dmel_TRRAP GNIE------RYVEIA---SSLC--IREWRRLP---NIVSH------------------- CG6535_Dmel_ATM ENSL------SAIEQA---YSCV--RDILM---EISVECLQ------------------- CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP SLAQ------QCIDKA---RDLL--DAELT---AMAGESYS------------------- DNAPK_Mmus_DNAPK DRAT------YYIKNG---IQIF--MQNYS---SIDVLLYR------------------- ATR_Mmus_ATR TTFY------DTLKLV---RAEQ--IVPLS-AASFERGSYQ------------------- ATM_Mmus_ATM STFY------ESLRYASLFRVKE--VEELS---KGSLESVY------------------- C47D12.1_Cele_TRRAP ERCK------IAIQEC---TEAH--ISRWRA---LPSVVSY------------------- B0261.2_Cele_FRAP TKAM------GLIEKV---REMI--DSELT---AMANESYE------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR EIVN------NAIENA---KSKV--IERLSECAIGGSCSYE------------------- TEL1_Scer_ATM GFAE------KSLEKS---L----------------LTIFD------------------- MEC1_Scer_ATR Y--KTLAEITKL------------------------------------------------ ATM_Hsap_ATM STFY------ESLKYA---RVKE--VEEMC---KRSLESVY------------------- ATR_Hsap_ATR TAFY------DSLKLV---RAEQ--IVPLS-AASFERGSYQ------------------- DNAPK_Hsap_DNAPK DRAK------YYIQNG---IQSF--MQNYS---SIDVLLHQ------------------- TOR_Dmel_FRAP ETAQ------RLIDET---RDLL--DTELT---SMAGESYE------------------- SMG1_Mmus_SMG1 ENVV------KYLKQT---SRIA--IGPLR---LSTL-TVS------------------- TRRAP_Mmus_TRRAP SFIE------RLVEMA---SSLA--IREWRRLP---HVVSH------------------- smg-1_Cele_SMG1 QMVD------GMIKE----KMISEGYNEDI---AKREEHMS------------------- TOR1_Scer_FRAP DNAS------KHILNA---RDLL--VTEIS---ALINESYN------------------- TOR2_Scer_FRAP KKAE------VHIFNA---RDLL--VTELS---ALVNESYN------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR KEFN------SNLFQC---RSFL--AQLLN---GSALDSYQ------------------- DNAPK_Ddis_DNAPK NKAS------YYVSKF---YQAF--KHQWS---SSHPLAIE------------------- SMG1_Ddis_SMG1 NNIN------SMLKLT---KNNI--LKALN---YLGLESNV------------------- Tor_Ddis_FRAP TLAH------GFIDHA---RTLV--DTELT---ALLGESYN------------------- TRRAP_Ddis_TRRAP HEVD------PAIVTS---NQLI--LDKWV---SLPERSFR------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK NRAK------YYLANS---TSSF--LQEWS---GLGPLMLT------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP TLIE------RLVEMS---SKQA--LEEWRRLP---HYVTQ------------------- CC1G_00839_Ccin_ATM NALD------ASIQSA---LYKE--MDQLRK---LG---TE------------------- CC1G_08126_Ccin_ATR QAIS------DALSLA---RLTL--GAPIS---AAGVNGYA------------------- CC1G_00894_Ccin_FRAP SKAL------AHIAKA---RELI--DPELS---SFTGEGYG------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K A--H------RVLSPH---RLVL--QMLFS---RLQASRYH------------------- CC1G_00331_Ccin_TRRAP AAIDKNVDFTRFLEDA---MQLS--LRKWV---GLPQHFSV------------------- AqueK043_Aque_ATM AQFD------EFITKG---RASI--INEMV---STSLESVC------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP NAVE------KLVEAA---SIQS--VKQWRRLP---HIVSN------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR VKFQ------EQLTHA---RLAL--LAPLA---AASMESYV------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP DEAG------IYAERA---RKCL--ATELA---ALVLESYD------------------- SMG1_Smoe_SMG1 EDAA------REVKLA---RAML--DGPLL---VSSLDDLS------------------- GK008_Glam_FRAP LEAH------KLLCKL---RLRI--DPDLI---GLSAESYT------------------- GK009_Glam_PIKK-Unclassified ----------------------------------------GVPESHTSCGTTATSIVTIR TRRAP_Hsap_TRRAP -----VHTPLL-Q--AAQQIIELQEAAQIN----------A-G-----L--Q--P----- SMG1_Hsap_SMG1 -----QSLPVL-STLQLYCSSALENTVSN-----------R-LS---------------- FRAP_Hsap_FRAP -----RAYGAM-V--SCHMLSELEEVIQYK------------------L--V-------- mei-41_Dmel_ATR -----NAYDAV-L--KLHLVHELHCSQELV----------E-K-----L--E--Q----- CG2905_Dmel_TRRAP -----IHLPYL-Q--ASQQIMELHEASQIH----------Q-G-----L--A--Q----- CG6535_Dmel_ATM -----SVYKYL-T--WLCSLQQAEDFCQIQ------------------F--G--T----- CG4549_Dmel_SMG1 ---------------SIHMRQRTEDIVLH-----------K-LLEDRC---V-------- FRAP_Mmus_FRAP -----RAYGAM-V--SCHMLSELEEVIQYK------------------L--V-------- DNAPK_Mmus_DNAPK -----SRLAKL-Q--SVQTLAEIEEFLSFI----------C-K----------------- ATR_Mmus_ATR -----RGYEFI-V--RLHMLCELEHSLKPL----------F-R-----K--S-------- ATM_Mmus_ATM -----SLYPTL-S--RLQAIGELENSGELF------------------S--R--S----- C47D12.1_Cele_TRRAP -----GHVKIL-Q--AMNLVREIEESTDIR----------I-A-----L--LEAP----- B0261.2_Cele_FRAP -----RAYIPM-V--SVQQMAELEEAIEYK------------------T--R--P----- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -----IATPFL-V--ELQKLNEIVELKNVS----------N------------------- TEL1_Scer_ATM -----SRQHFI-S--QTEWMDTLNAIIEFI----------K-------------I----- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----SLYPTL-S--RLQAIGELESIGELF------------------S--R--S----- ATR_Hsap_ATR -----RGYEYI-V--RLHMLCELEHSIKPL----------F-Q-----H--S-------- DNAPK_Hsap_DNAPK -----SRLTKL-Q--SVQALTEIQEFISFI----------S-K----------------- TOR_Dmel_FRAP -----RAYGAM-V--CVQMLAELEEVIQYK------------------L--I--P----- SMG1_Mmus_SMG1 -----QSLPVL-STLQLYCSSALENTVSN-----------R-LS---------------- TRRAP_Mmus_TRRAP -----VHTPLL-Q--AAQQIIELQEAAQIN----------A-G-----L--Q--P----- smg-1_Cele_SMG1 -----RASIQLAD--FFQSLPELENVLAP--------------------NLF--P----- TOR1_Scer_FRAP -----RAYSVI-V--RTQIITEFEEIIKYK------------------Q--L--P----- TOR2_Scer_FRAP -----RAYNVV-V--RAQIIAELEEIIKYK------------------K--L--P----- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -----RCYPYL-I--QAHILEEIEQSYKLI----------HYN-----V--I--PIENVT DNAPK_Ddis_DNAPK -----SRHRIL-Q--PLQKIVEVEEFLNLT----------S-T----------------- SMG1_Ddis_SMG1 -----QTFQYL-T--QLKIMDEIENGV--------------------------------- Tor_Ddis_FRAP -----RAYKVV-V--RLQQLSELEEIIEYK------------------K--C--V----- TRRAP_Ddis_TRRAP -----SHTNSL-V--EMQQVVELQESVHIL----------K-EISNITLSQQ--P----- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -----SRLSKL-Q--DIQKLTEAEQFLQLA----------N-K----------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----AHTPLL-Q--ASQRIMELQEASQVH----------H-G-----L--Q--P----- CC1G_00839_Ccin_ATM -----SVTQIR-E--VLQALMSLHQISLWK----------S------------------- CC1G_08126_Ccin_ATR -----RSYEAA-L--SLHHLYELELIHNTT----------R-N-----L--P--S----- CC1G_00894_Ccin_FRAP -----RSYNVM-V--RAQMLSELEEIIAYK------------------Q--Y--A----- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ---------------------KLEELVSDS----------M-NLPP-------------- CC1G_13883_Ccin_PI4K -----RPAILL-L--TQQ------------------------------------------ CC1G_00331_Ccin_TRRAP -----AHIPLL-Q--HFQQFVELQEAVQIF----------G-S-----L--S--Q----- AqueK043_Aque_ATM -----NINPHL-T--RLQTLNELESTFQLV------------------L--E--P----- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -----SHIPLL-Q--LSQQIIELQEATQIH----------S-G-----L--Q--S----- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -----RAYPVI-V--KLHMLRELEDFFSL-------------A-----D--K--G----- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -----RAYSNM-V--RVQQLAELEEVIEYC------------------T--L--Q----- SMG1_Smoe_SMG1 -----DAAPYL-T--QLHCIEVVESWKG---------------PSERQ------------ GK008_Glam_FRAP -----RAYNLC-I--LLQTITELQNIISYK------------------L--A--L----- GK009_Glam_PIKK-Unclassified NLLHQY-SNML-L--RVSMWTELTQFLREQDFFDQMLLALDQF-----------PA---- TRRAP_Hsap_TRRAP --------------TNLG--R------------------------------N--NSL--- SMG1_Hsap_SMG1 ----------------T-ED---------------------------------------- FRAP_Hsap_FRAP --------------------------------------------------------P--- mei-41_Dmel_ATR --------------DR----D------------------------------E-DNQE--- CG2905_Dmel_TRRAP -----------------S--R------------------------------N--NSL--- CG6535_Dmel_ATM ---------------------------------------------------Q-L-DP--- CG4549_Dmel_SMG1 --------------PDQAKN---------------------------------------- FRAP_Mmus_FRAP --------------------------------------------------------P--- DNAPK_Mmus_DNAPK ----------------HG--D------------------------------L--SSL--- ATR_Mmus_ATR ---------------------------------------------------P-GDSC--- ATM_Mmus_ATM -----------------------------------------------------V-TD--- C47D12.1_Cele_TRRAP --------------SNKV--D------------------------------Q--ALM--- B0261.2_Cele_FRAP -----------------------------------------------------E-R---- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR --------------DEL---------------------------------------S--- TEL1_Scer_ATM --------------AA----I------------------------------P-QDVTSFP MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----------------------------------------------------V-TH--- ATR_Hsap_ATR ---------------------------------------------------P-GDSS--- DNAPK_Hsap_DNAPK ----------------QG--N------------------------------L--SSQ--- TOR_Dmel_FRAP -----------------------------------------------------E-R---- SMG1_Mmus_SMG1 ----------------T-ED---------------------------------------- TRRAP_Mmus_TRRAP --------------TNLG--R------------------------------N--NSL--- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -----------------------------------------------------P-NS--- TOR2_Scer_FRAP -----------------------------------------------------Q-NS--- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ITNNNNNIGNNNNSNN----N------------------------------N-VQKQ--- DNAPK_Ddis_DNAPK ----------------PI--I------------------------------N----T--- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -----------------------------------------------------D-SP--- TRRAP_Ddis_TRRAP --------------ADLSRS-------------------------------F-L-TS--- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ----------------PF--S------------------------------E--GLK--- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --------------TNLG--R------------------------------N--QSL--- CC1G_00839_Ccin_ATM ---------------RDL---------------------------------Q--DNL--- CC1G_08126_Ccin_ATR --------------S------------------------------------S-TRRK--- CC1G_00894_Ccin_FRAP -----------------------------------------------------D-Q---- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K -------------------------------------------------------TP--- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --------------TNAQ--N------------------------------L-EKKS--- AqueK043_Aque_ATM --------------------------------------------------------D--- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP --------------GSLS--R------------------------------Q--SFL--- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR --------------------------------------------------------G--- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------------T----GN------------------------------P-A-SE--- SMG1_Smoe_SMG1 --------------EGI-QD---------------------------------------- GK008_Glam_FRAP --------------N----GLKLDAPSTLIKEGGNPYENIFETTLISFNPPPGF-AD--- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP HDM-------------------------KTVVKTWRNRLPIV------------------ SMG1_Hsap_SMG1 -----------------------------CLIPLFSEALRSCK----------------- FRAP_Hsap_FRAP ERR-------------------------EIIRQIWWERLQGC------------------ mei-41_Dmel_ATR KLM-------------------------KNYFDDWQYRLQIV------------------ CG2905_Dmel_TRRAP HDM-------------------------KAIVKTWRNRLPII------------------ CG6535_Dmel_ATM AST-------------------------TKIFRKWQTELELK------------------ CG4549_Dmel_SMG1 -----------------------------LLDTQWRDSLLNPSFDQRSCKELTLLRHIVQ FRAP_Mmus_FRAP ERR-------------------------EIIRQIWWERLQGC------------------ DNAPK_Mmus_DNAPK GPL-------------------------RRLLKTWTSRYPDV------------------ ATR_Mmus_ATR ----------------------------NEDSLNWGARLEMT------------------ ATM_Mmus_ATM RER-------------------------SEAYWKWQKHSQLL------------------ C47D12.1_Cele_TRRAP GDM-------------------------KSLMKVFRNRTPTT------------------ B0261.2_Cele_FRAP --R-------------------------PRIALLWSRRLQGC------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR AFN-------------------------SDFWKNIQKRTDDS------------------ TEL1_Scer_ATM QTL-------------------------MSIMKADKERL--N------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM RQL-------------------------SEVYIKWQKHSQLL------------------ ATR_Hsap_ATR ----------------------------QEDSLNWVARLEMT------------------ DNAPK_Hsap_DNAPK VPL-------------------------KRLLNTWTNRYPDA------------------ TOR_Dmel_FRAP --R-------------------------EPLKTMWWKRLQGG------------------ SMG1_Mmus_SMG1 -----------------------------CLIPLFSDALRSCK----------------- TRRAP_Mmus_TRRAP HDM-------------------------KTVVKTWRNRLPIV------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP EKK-------------------------LHYQNLWTKRLLGC------------------ TOR2_Scer_FRAP DKR-------------------------LTMRETWNTRLLGC------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR QML-------------------------KKLLSEWDDRLKII------------------ DNAPK_Ddis_DNAPK LKL-------------------------DTLLTQWKSRFPTK------------------ SMG1_Ddis_SMG1 ----------------------------------YNSRVVPI------------------ Tor_Ddis_FRAP ERR-------------------------NMIKNTWKTRLRGC------------------ TRRAP_Ddis_TRRAP NYI-------------------------KSIFNIWRERLPNK------------------ ATMa_Spur_ATM TDS-------------------------QPIFDAWTSQLPLM------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK SSA-------------------------TRLVSDWSRNLPDP------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP HDM-------------------------KAIVKTWRNRLPMV------------------ CC1G_00839_Ccin_ATM SSK-------------------------AIDFDKWKDFLSIS------------------ CC1G_08126_Ccin_ATR QAL-------------------------TRLSSILADRLENV------------------ CC1G_00894_Ccin_FRAP --P-------------------------ER-QATMRKTLQGC------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K KNK-------------------------DL------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP SEL-------------------------KMVLQAWRERLPNV------------------ AqueK043_Aque_ATM LSP-------------------------SVLLSNWKGKLSNM------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP NEV-------------------------KTIFKTWKNRLPNH------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR DNK-------------------------DQLFENWNGRLKMT------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ARA-------------------------SLIRRMWRDRIRGA------------------ SMG1_Smoe_SMG1 -----------------------------ISLKYFNHPADEV------------------ GK008_Glam_FRAP TEK-------------------------ERLRLMWSRKISMI------------------ GK009_Glam_PIKK-Unclassified -NTHAHFIAQLRRHKSLLFQHNCQFLYKQILNLACARYRECR------------------ TRRAP_Hsap_TRRAP -----------------------------S-DDLSHWSSI-------------------- SMG1_Hsap_SMG1 -----------------------------Q-HDVRPWMQA-------------------- FRAP_Hsap_FRAP -----------------------------Q-RIVEDWQKI-------------------- mei-41_Dmel_ATR -----------------------------Q-PQVRIQESI-------------------- CG2905_Dmel_TRRAP -----------------------------S-DDLSHWSDI-------------------- CG6535_Dmel_ATM -----------------------------Y-GNFSCKEYV-------------------- CG4549_Dmel_SMG1 GVSGGQELSLLPVSSGRCQNRSKFISSAIL-MRCLAWTQL-------------------- FRAP_Mmus_FRAP -----------------------------Q-RIVEDWQKI-------------------- DNAPK_Mmus_DNAPK -----------------------------VTDPMHIWDDI-------------------- ATR_Mmus_ATR -----------------------------Q-NSYRAKEPI-------------------- ATM_Mmus_ATM -----------------------------KDSDFSFQEPL-------------------- C47D12.1_Cele_TRRAP -----------------------------SD-DMGFVSTW-------------------- B0261.2_Cele_FRAP -----------------------------R-RNVEQWQRL-------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -----------------------------E-QKISILEPI-------------------- TEL1_Scer_ATM -----------------------------T-IDFYDHKTT-------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----------------------------KDSDFSFQEPI-------------------- ATR_Hsap_ATR -----------------------------Q-NSYRAKEPI-------------------- DNAPK_Hsap_DNAPK -----------------------------KMDPMNIWDDI-------------------- TOR_Dmel_FRAP -----------------------------Q-RLVEDWRRI-------------------- SMG1_Mmus_SMG1 -----------------------------Q-HDVRPWMQA-------------------- TRRAP_Mmus_TRRAP -----------------------------S-DDLSHWSSV-------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -----------------------------Q-KNVDLWQRV-------------------- TOR2_Scer_FRAP -----------------------------Q-KNIDVWQRI-------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -----------------------------Q-PSFKLRESI-------------------- DNAPK_Ddis_DNAPK -----------------------------L-DDIMVWDDL-------------------- SMG1_Ddis_SMG1 -----------------------------N-NQIGFLERL-------------------- Tor_Ddis_FRAP -----------------------------Q-HNVDIWQSI-------------------- TRRAP_Ddis_TRRAP -----------------------------D-EDLLIWFEL-------------------- ATMa_Spur_ATM -----------------------------N-NSFEFSEPT-------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -----------------------------KRDPISVWDDV-------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----------------------------S-DDLSHWSDI-------------------- CC1G_00839_Ccin_ATM -----------------------------DHFGFSDVENI-------------------- CC1G_08126_Ccin_ATR -----------------------------L-PTFRNLEPI-------------------- CC1G_00894_Ccin_FRAP -----------------------------Q-PDVEVWQRI-------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K --------------------------------DLATWSRSSPMGSFSSSFGSPHSRQPSQ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -----------------------------Y-DDINIWSDL-------------------- AqueK043_Aque_ATM -----------------------------S-TDFELVELV-------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -----------------------------F-DDLSYWSDI-------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -----------------------------L-PSLSTREPI-------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -----------------------------K-RNVEVWQRL-------------------- SMG1_Smoe_SMG1 -----------------------------Y-QDCHLWLKV-------------------- GK008_Glam_FRAP -----------------------------R-WDCESWEAL-------------------- GK009_Glam_PIKK-Unclassified ------------------------------YTDLSVRLLVHEFIDNNLFDFAEDTQSFII TRRAP_Hsap_TRRAP -----------------------------FMWR---QHHY---------QGKPTWSGMHS SMG1_Hsap_SMG1 -----------------------------LRYTMYQNQLL---------E---------- FRAP_Hsap_FRAP -----------------------------LMVR---SLVV---------SP--------- mei-41_Dmel_ATR -----------------------------YSFR---RNIL---------AE--------- CG2905_Dmel_TRRAP -----------------------------FTWR---QHHY---------QI--------- CG6535_Dmel_ATM -----------------------------IAHQ---IALL---------KL--------- CG4549_Dmel_SMG1 -----------------------------LRQH------C---------A---------- FRAP_Mmus_FRAP -----------------------------LMVR---SLVV---------SP--------- DNAPK_Mmus_DNAPK -----------------------------ITNR---CFFL---------SK--------- ATR_Mmus_ATR -----------------------------LALR---RALL---------SL--------- ATM_Mmus_ATM -----------------------------MALR---TVIL---------ET--------- C47D12.1_Cele_TRRAP -----------------------------YDWR---NQIH---------GM--------- B0261.2_Cele_FRAP -----------------------------IMLR---GLVL---------SP--------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -----------------------------LRVR---RSML---------DI--------- TEL1_Scer_ATM -----------------------------LKSR---HTLM---------NV--------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----------------------------MALR---TVIL---------EI--------- ATR_Hsap_ATR -----------------------------LALR---RALL---------SL--------- DNAPK_Hsap_DNAPK -----------------------------ITNR---CFFL---------SK--------- TOR_Dmel_FRAP -----------------------------IQVH---SLVV---------KP--------- SMG1_Mmus_SMG1 -----------------------------LRYTMYQNQLL---------E---------- TRRAP_Mmus_TRRAP -----------------------------FMWR---QHHY---------QGKPTWSGMHS smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -----------------------------LRVR---SLVI---------KP--------- TOR2_Scer_FRAP -----------------------------LRVR---SLVI---------KP--------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -----------------------------LSVR---REIL---------EI--------- DNAPK_Ddis_DNAPK -----------------------------IFYR---SVLL---------EK--------- SMG1_Ddis_SMG1 -----------------------------RRVR---GHIS---------N---------- Tor_Ddis_FRAP -----------------------------LAVH---SLVI---------SP--------- TRRAP_Ddis_TRRAP -----------------------------MAWR---QQVF---------NI--------- ATMa_Spur_ATM -----------------------------LALR---SIL-S--------RL--------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -----------------------------TQYR---CLYM---------DK--------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----------------------------FMWR---QHHY---------QA--------- CC1G_00839_Ccin_ATM -----------------------------MSVR---LSLI---------RS--------- CC1G_08126_Ccin_ATR -----------------------------LSTR---RIGF---------SL--------- CC1G_00894_Ccin_FRAP -----------------------------LQVR---TLVS---------SP--------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K TRVSMERTHSSPTPSTPASVDYSGNALSLDEYS---ERMRTAAIMLAQLNS--------- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -----------------------------VAWR---QNVF---------HS--------- AqueK043_Aque_ATM -----------------------------LSVR---FHALL--------SV--------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -----------------------------FLWR---EQHF---------RS--------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -----------------------------LALR---RLLF---------SV--------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -----------------------------LSVR---TLVL---------PP--------- SMG1_Smoe_SMG1 -----------------------------LRVY---KT-V---------F---------- GK008_Glam_FRAP -----------------------------LRVR---RLII---------FP--------- GK009_Glam_PIKK-Unclassified EAMFGELMVDLDGIEGKNSSIVSMSTRCSFVGNMYSALATYTFILAIIHRMLFRRPLGGP TRRAP_Hsap_TRRAP SSIVTAYENSS-----------QH---DPS-SNNA--ML------GVH------------ SMG1_Hsap_SMG1 -------------------------------------------KI--KEQTVPIRSHL-- FRAP_Hsap_FRAP --HE-------------------------------------------------------- mei-41_Dmel_ATR --LQRRLTDRN-----------------------H--LL----PHLKT------------ CG2905_Dmel_TRRAP --ITQHLE-------------Q-Q----SD-QGST--ML------GVH------------ CG6535_Dmel_ATM --AGTRASRRM-----------S----EF--YQKD------------------------- CG4549_Dmel_SMG1 -------------------------------------------PG----S-------W-- FRAP_Mmus_FRAP --HE-------------------------------------------------------- DNAPK_Mmus_DNAPK --IEERLTAPSGDH--S-MSVDED---EESIDR-E--VY------EPK------------ ATR_Mmus_ATR --NKR--------------------------------------PDYNE------------ ATM_Mmus_ATM --LVQKEMERS-----------Q----GA--CSKD------------------------- C47D12.1_Cele_TRRAP --MLQRFEYWD-KV--G----LNV---AAT-GNQS--IV------PIH------------ B0261.2_Cele_FRAP --QE-------------------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR --RMQSMT-------------GRD---KEN-IRSR--IV--------------------- TEL1_Scer_ATM --LSRNSLDE-------------------------------------------------- MEC1_Scer_ATR ----------YKNS--V-T----KDASDSEN----------------------------- ATM_Hsap_ATM --LMEKEMDNS-----------Q----RE--CIKD------------------------- ATR_Hsap_ATR --NKR--------------------------------------PDYNE------------ DNAPK_Hsap_DNAPK --IEEKLTPLPEDN--S-MNVDQD---GDPSDRME--VQ------EQE------------ TOR_Dmel_FRAP --HE-------------------------------------------------------- SMG1_Mmus_SMG1 -------------------------------------------KI--KEQTVPIRSHL-- TRRAP_Mmus_TRRAP SSIVTAYENSS-----------HH---DPS-SNNA--ML------GVH------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP --KQ-------------------------------------------------------- TOR2_Scer_FRAP --KE-------------------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR --GS-----------------------------------------FSK------------ DNAPK_Ddis_DNAPK --IYERFSSFTSDK--------SS---DE------------------------------- SMG1_Ddis_SMG1 -------------------------------------------TK----QRSDILLSN-- Tor_Ddis_FRAP --HE-------------------------------------------------------- TRRAP_Ddis_TRRAP --IGT--------------------------------------PS--MN------GGIGA ATMa_Spur_ATM --VP-DAMDGD-----------Q----HK--KLHD------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK --LCNLLGDSGGGGGGGGDSMET-----------------------ED------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --IVQAYDNSS--------STTQD---NQQ-HNHT--ML------GVH------------ CC1G_00839_Ccin_ATM --NR------------------QE---EEK-TNQIGSIASPFLTALVE------------ CC1G_08126_Ccin_ATR --MPG-TSPD-----------------------------------LVK------------ CC1G_00894_Ccin_FRAP --EQ-------------------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K --GIM----------------------------------------------------RSD CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --INLAYVPLIENL--A-QSAPGG---NQNTNTYG--YR------GYH------------ AqueK043_Aque_ATM --LP-YY-KRS-----------G----GE--N---------------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP --IIKAYDGTS--------H-------GEQ-SNQA--ML------AVH------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR --CD-----------------------------------------LQS------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --TE-------------------------------------------------------- SMG1_Smoe_SMG1 -------------------------------------------PH--AGV-------T-- GK008_Glam_FRAP --IE-------------------------------------------------------- GK009_Glam_PIKK-Unclassified DSFS-------------------------------------------------------- TRRAP_Hsap_TRRAP ----------------------------------------------A---------SASA SMG1_Hsap_SMG1 ---------------------------------------------------------MEL FRAP_Hsap_FRAP --------------------------------------------------------DMRT mei-41_Dmel_ATR ----------------------------------------------E---------LARI CG2905_Dmel_TRRAP ----------------------------------------------A---------SAQA CG6535_Dmel_ATM ----------------------------------------------P---------ISTY CG4549_Dmel_SMG1 ---------------------------------------------------------ETL FRAP_Mmus_FRAP --------------------------------------------------------DMRT DNAPK_Mmus_DNAPK ----------------------------------------------EDVRCMLQSCRFTM ATR_Mmus_ATR ----------------------------------------------M---------VGEC ATM_Mmus_ATM ----------------------------------------------I---------LTKH C47D12.1_Cele_TRRAP ----------------------------------------------S---------MAQA B0261.2_Cele_FRAP --------------------------------------------------------MHPL atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ----------------------------------------------------------EV TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ----------------------------------------------I---------LTKH ATR_Hsap_ATR ----------------------------------------------M---------VGEC DNAPK_Hsap_DNAPK ----------------------------------------------EDISSLIRSCKFSM TOR_Dmel_FRAP --------------------------------------------------------DIHT SMG1_Mmus_SMG1 ---------------------------------------------------------MEL TRRAP_Mmus_TRRAP ----------------------------------------------A---------SASA smg-1_Cele_SMG1 ----------------------------------TIIWS-----ELQ------------- TOR1_Scer_FRAP --------------------------------------------------------DLQI TOR2_Scer_FRAP --------------------------------------------------------DAQV TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ----------------------------------------------E---------VIDC DNAPK_Ddis_DNAPK -----------------------------------------------KVKSTLIQERAIL SMG1_Ddis_SMG1 ---------------------------------------------------------IPL Tor_Ddis_FRAP --------------------------------------------------------ELDM TRRAP_Ddis_TRRAP NPVTPTNTTTTITNPDGTTTTTTTPLPPPQQPINQIEFASPRYMVLE---------MAWT ATMa_Spur_ATM ----------------------------------------------G---------IASH ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ----------------------------------------------QKFDDLVRREKVLL FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----------------------------------------------A---------SAQS CC1G_00839_Ccin_ATM ----------------------------------------------I---------EKRC CC1G_08126_Ccin_ATR ----------------------------------------------E---------VGKA CC1G_00894_Ccin_FRAP --------------------------------------------------------DPVM CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K APV---------TASPRPD-------ANDSN-------PAARMK---------------- CC1G_13883_Ccin_PI4K -----------------------------------------------------------L CC1G_00331_Ccin_TRRAP ----------------------------------------------E---------TAWI AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ----------------------------------------------H---------LAGG ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ----------------------------------------------E---------MGGC DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP --------------------------------------------------------DAET SMG1_Smoe_SMG1 ---------------------------------------------------------STL GK008_Glam_FRAP --------------------------------------------------------DQEV GK009_Glam_PIKK-Unclassified --------------------------------------------------------KADC TRRAP_Hsap_TRRAP IIQYGKIARKQGL--------VN----------------------VALDILSRIH----- SMG1_Hsap_SMG1 GLTAAKFARKRGN--------VS----------------------LATRLLAQCS----- FRAP_Hsap_FRAP WLKYASLCGKSGR--------LA----------------------LAHKTLVLLL----- mei-41_Dmel_ATR WLNSAQINRNAGQ--------LQ----------------------RAQLYILKAA----- CG2905_Dmel_TRRAP IISFGKIARKHNL--------TG----------------------VCQETLSRIY----- CG6535_Dmel_ATM LMKGIEECKSAGK--------LN----------------------LAAKYTATLR----- CG4549_Dmel_SMG1 CLDAAAAAREEGN--------LQ----------------------LAETLLTQFF----- FRAP_Mmus_FRAP WLKYASLCGKSGR--------LA----------------------LAHKTLVLLL----- DNAPK_Mmus_DNAPK KMKMIESAWKQSN--------FS----------------------LSMKLLKEMH----- ATR_Mmus_ATR WLQSARVARKAGH--------HQ----------------------TAYNALLNAG----- ATM_Mmus_ATM LVEFSVLARTFKN--------TQ----------------------LPERAIFKIK----- C47D12.1_Cele_TRRAP QLAVAKHAKNLGF--------HN----------------------LTKDLLNKLA----- B0261.2_Cele_FRAP RVKFSSMCRKQGK--------NS----------------------MSRAVLRELL----- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR HLQSARIARLTGC--------FE----------------------RAQLSLIN------- TEL1_Scer_ATM NVKCSKYLRLGSI--------IQLANYVQLAIANGAPQDALRNATLMSKTVKNIA----- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM LVELSILARTFKN--------TQ----------------------LPERAIFQIK----- ATR_Hsap_ATR WLQSARVARKAGH--------HQ----------------------TAYNALLNAG----- DNAPK_Hsap_DNAPK KMKMIDSARKQNN--------FS----------------------LAMKLLKELH----- TOR_Dmel_FRAP WLKYASLCRKSGS--------LH----------------------LSHKTLVMLL----- SMG1_Mmus_SMG1 GLTAAKFARKRGN--------VS----------------------LATRLLAQCS----- TRRAP_Mmus_TRRAP IIQYGKIARKQGL--------VN----------------------VALDILSRIH----- smg-1_Cele_SMG1 --------RRSDSLSAGYHGIVG----------------------SL------------- TOR1_Scer_FRAP WIKFANLCRKSGR--------MR----------------------LANKALNMLL----- TOR2_Scer_FRAP RIKFANLCRKSGR--------MA----------------------LAKKVLNTLL----- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR WMKIGKYARHDKK--------FE----------------------LSLNAILKPT----- DNAPK_Ddis_DNAPK YHKMSKGARKLGN--------IV----------------------VSEIYFRQAVK---- SMG1_Ddis_SMG1 TEKMIKLSRKFEN--------YK----------------------FSSKLLDTIL----- Tor_Ddis_FRAP WLKFVGLCRKGSR--------LG----------------------LAQKTLTMLM----- TRRAP_Ddis_TRRAP MNKYSHIVRKHNI--------IE----------------------VCLNSLSKMF----- ATMa_Spur_ATM LKTQIQWARDAER--------FQ----------------------VAERALVHLK----- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK SMKMADSACQQAN--------FC----------------------VAAKHLKSTH----- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP IINYGKVARKHSL--------IG----------------------PALDSLSRIH----- CC1G_00839_Ccin_ATM LILLSRAARDSDQ--------TQ----------------------IALNAVLQAQ----- CC1G_08126_Ccin_ATR WLSSAKVARKAGH--------WP----------------------TAYSAILQAR----- CC1G_00894_Ccin_FRAP WIKFANLCRKNDR--------MM----------------------LAEKTINSLL----- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K VLRTAYACKSLST--------HA----------------------LAREIRFSLLLFGFE CC1G_00331_Ccin_TRRAP INRFAHVARKHGL--------LD----------------------VCFTYLNKIY----- AqueK043_Aque_ATM ---------------------ES----------------------LIQSGLLNVL----- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ITQFSSIARKQKL--------IT----------------------VSLDSLSRIH----- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR WLQYAKLCRTSGH--------YE----------------------TANRAILQAQ----- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP WLKFASLCYKSGR--------YD----------------------PEQS----------- SMG1_Smoe_SMG1 RRQLIRLARKHGN--------FR----------------------LARRMLKEMD----- GK008_Glam_FRAP WIRFSVLCLQSGR--------VQ----------------------LARKTLETFI----- GK009_Glam_PIKK-Unclassified WSRF-------------------------------------------------------- TRRAP_Hsap_TRRAP --------------------------TI-------------------------------- SMG1_Hsap_SMG1 --------------------------EVQLGKTTTAQDLVQHFKKL-------------- FRAP_Hsap_FRAP --------------------------GVDPS-------------RQ-------------- mei-41_Dmel_ATR --------------------------EY-------------------------------- CG2905_Dmel_TRRAP --------------------------TI-------------------------------- CG6535_Dmel_ATM --------------------------ELPNI-------------R--------------- CG4549_Dmel_SMG1 --------------------------GQPIGEIAALFSLE-------------------- FRAP_Mmus_FRAP --------------------------GVDPS-------------RQ-------------- DNAPK_Mmus_DNAPK --------------------------KE-------------------------------- ATR_Mmus_ATR --------------------------ES-------------------------------- ATM_Mmus_ATM --------------------------Q--------------------------------- C47D12.1_Cele_TRRAP --------------------------GLTAI----------------------------- B0261.2_Cele_FRAP --------------------------SLPAN--------------S-------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR --------------------------AK-------------------------------- TEL1_Scer_ATM --------------------------KL-------------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM --------------------------Q--------------------------------- ATR_Hsap_ATR --------------------------ES-------------------------------- DNAPK_Hsap_DNAPK --------------------------KE-------------------------------- TOR_Dmel_FRAP --------------------------GTDPK-------------LN-------------- SMG1_Mmus_SMG1 --------------------------EVQLGKTTTAQDLVQHFKKL-------------- TRRAP_Mmus_TRRAP --------------------------TI-------------------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP --------------------------EGGND-------------P--------------- TOR2_Scer_FRAP --------------------------EETDD-------------P--------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR --------------------------PS-------------------------------- DNAPK_Ddis_DNAPK --------------------------SY-------------------------------- SMG1_Ddis_SMG1 --------------------------ES-------------------------------- Tor_Ddis_FRAP --------------------------GKDPS-------------TT-------------- TRRAP_Ddis_TRRAP --------------------------D--------------------------------- ATMa_Spur_ATM --------------------------ELEQK-------------Q--------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK --------------------------RG-------------------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --------------------------TI-------------------------------- CC1G_00839_Ccin_ATM --------------------------KLEKT----------------------------- CC1G_08126_Ccin_ATR --------------------------QS-------------------------------- CC1G_00894_Ccin_FRAP --------------------------TPERR-------------ML-------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K TLRGCYLDSYCENLLRESLYKTAYSWF--------------------------------- CC1G_00331_Ccin_TRRAP --------------------------TL-------------------------------- AqueK043_Aque_ATM --------------------------STK------------------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP --------------------------NI-------------------------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR --------------------------AA-------------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 --------------------------GEN------------------------------- GK008_Glam_FRAP --------------------------NSSSV-------------HHIKVSKSRGLYTLLG GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP LTSFGTPRRYLKHGSGDVSTGGSVTPIGSALGAEMGVVQDLSAVGSSLAKYLLKDGVVKD GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP AFTAQQHVALPTSDVLSIASHSVAKPTLQMIANASTHQGQSIEKETPLSIVGQQCDDAKR GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ----------------------------P-TVP--------------------------I SMG1_Hsap_SMG1 -------STQGQVDE-KWG---------PE-L---------------------------D FRAP_Hsap_FRAP ---------LDHPLP-TVH---------PQ-V---------------------------T mei-41_Dmel_ATR -----------------QP---------S-GL---------------------------F CG2905_Dmel_TRRAP ----------------------------P-SVP--------------------------I CG6535_Dmel_ATM -------E---S-----IK---------IS-V---------------------------L CG4549_Dmel_SMG1 -----------QGVQ-TDN---------PE-M---------------------------L FRAP_Mmus_FRAP ---------LDHPLP-TAH---------PQ-V---------------------------T DNAPK_Mmus_DNAPK ----------------------------S-KTR--------------------------E ATR_Mmus_ATR -----------------RL---------A-EL---------------------------Y ATM_Mmus_ATM -----------YNSAICGI---------SE-W---------------------------H C47D12.1_Cele_TRRAP -----------------PM---------MD-A---------------------------Q B0261.2_Cele_FRAP -------DLVRAKAP-FDK---------PL-L---------------------------V atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ----------------------------K-VLP--------------------------F TEL1_Scer_ATM -----------------YDDPSVVSQIEK-LA---------------------------S MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----------YNSVSCGV---------SE-W---------------------------Q ATR_Hsap_ATR -----------------RL---------A-EL---------------------------Y DNAPK_Hsap_DNAPK ----------------------------S-KTR--------------------------D TOR_Dmel_FRAP ---------PNQPLP-CNQ---------PQ-V---------------------------T SMG1_Mmus_SMG1 -------STQGQVDE-KWG---------PE-L---------------------------D TRRAP_Mmus_TRRAP ----------------------------P-TVP--------------------------I smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -------SL--PNTF-KAP---------PP-V---------------------------V TOR2_Scer_FRAP -------DH--PNTA-KAS---------PP-V---------------------------V TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -----------------QQ---------DKFY---------------------------F DNAPK_Ddis_DNAPK ----------------------------P-KTK--------------------------D SMG1_Ddis_SMG1 -----------------HS---------SS-Y---------------------------Y Tor_Ddis_FRAP -------SQFGSVLP-NTH---------PR-I---------------------------T TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM -------D---QNTVLEG----------CS-S---------------------------S ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ----------------------------L-VEF--------------------------E FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----------------------------P-SVP--------------------------V CC1G_00839_Ccin_ATM -----------------PS---------LE-V---------------------------S CC1G_08126_Ccin_ATR -----------------GT---------P-LW---------------------------F CC1G_00894_Ccin_FRAP -------DHHHHHNT-KAP---------PN-V---------------------------V CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ----------------AVR---------PR-VSFGANRVQVDADVKVCSEFLAYLHSDSV CC1G_00331_Ccin_TRRAP ----------------------------P-NI---------------------------- AqueK043_Aque_ATM ----------------------------AS-L---------------------------A AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ----------------------------P-SVP--------------------------V ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -----------------GA---------P-NA---------------------------H DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -------DP--PPGY-VVN---------PP-V---------------------------M SMG1_Smoe_SMG1 -----------------WD---------SKVA---------------------------A GK008_Glam_FRAP NAQRDLFNALIPPLN-HVY---------PH-V---------------------------L GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP V----------------------------DC-------FQ---KIRQQVKCYLQLAGVMG SMG1_Hsap_SMG1 I---EK-------TKLLY--------TAGQS--------T---HAMEMLSS--------- FRAP_Hsap_FRAP Y---AY-------MKNMW--------KSARK--------I---DAFQHMQH--------- mei-41_Dmel_ATR I---ER-------AKLLW--------QKGDQ--------V---MAMNYLEE--------- CG2905_Dmel_TRRAP V----------------------------DC-------FQ---KIRQQVKCYLQMPSTSG CG6535_Dmel_ATM L---ED-------AEINL--------KMGNQ--------Q---IAKAILDY--------- CG4549_Dmel_SMG1 RGYSEL-------VKCLHLQQQQSQTHSGDL--------S---SSIDVCAA--------- FRAP_Mmus_FRAP Y---AY-------MKNMW--------KSARK--------I---DAFQHMQH--------- DNAPK_Mmus_DNAPK I---WR-------VQWLH--------SYSQLN-HCRSHTQ---SPREQVLNML------- ATR_Mmus_ATR V---ER-------AKWLW--------SKGDV--------H---QALIVLQK--------- ATM_Mmus_ATM L---EE-------AQVFW--------AKKEQ--------S---LALSILKQ--------- C47D12.1_Cele_TRRAP D---KVCTYGKTLRDM-A--------NSAADERVKNELLC---EALEVLED--------- B0261.2_Cele_FRAP L---AL-------AKQLY--------QDDHK--------D---EAIRALED--------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR E----------------------------N---------K---IVLEEAKLQLQ------ TEL1_Scer_ATM F---TS-------ANALW--------ESREY--------K---APVMIMRD--------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM L---EE-------AQVFW--------AKKEQ--------S---LALSILKQ--------- ATR_Hsap_ATR V---ER-------AKWLW--------SKGDV--------H---QALIVLQK--------- DNAPK_Hsap_DNAPK D---WL-------VSWVQ--------SYCRLS-HCRSRSQ---GCSEQVLTVL------- TOR_Dmel_FRAP Y---AY-------TKYMA--------ANNQL--------Q---EAYEQLTH--------- SMG1_Mmus_SMG1 I---EK-------TKLLY--------TAGQS--------T---HAMEMLSS--------- TRRAP_Mmus_TRRAP V----------------------------DC-------FQ---KIRQQVKCYLQLAGVMG smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP Y---AQ-------LKYIW--------ATGAY--------K---EALNHLIG--------- TOR2_Scer_FRAP Y---AQ-------LKYLW--------ATGLQ--------D---EALKQLIN--------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR I---EH-------AKLMW--------NQGHS--------F---EAINILTQ--------- DNAPK_Ddis_DNAPK N---DLA------FPLVT--------SLIDIYCTKARNSP---SPIETLDRFV------- SMG1_Ddis_SMG1 L---ER-------CKLKY--------LNGKQ--------T---EATLDLIK--------- Tor_Ddis_FRAP F---AY-------IKQLW--------SAGAK--------Q---PAFEKLRT--------- TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM L---EE-------AQLFW--------AKNER--------T---TALHLMKA--------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK D---LR-------PAWTH--------SYVSMT-QRKALLL---KPYERITSLL------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP V----------------------------DC-------FQ---KIRQQVKCYLQMAGTMG CC1G_00839_Ccin_ATM Q---EY-------ANVLW--------SLGEA--------K---IAVKFLSD--------- CC1G_08126_Ccin_ATR L---ES-------AKLMK--------ASGDF-------IM---KAVRELESHM------- CC1G_00894_Ccin_FRAP Y---AQ-------LKYMW--------ANGEK--------E---ETLNHLRL--------- CC1G_06302_Ccin_PI3K V---QA-------LKFES------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K R---GA-------PAISS--------LSPV------------QLMSRAAYY--------- CC1G_00331_Ccin_TRRAP --------------EIS------------EA-------FL---KLREQARCHYQKP---- AqueK043_Aque_ATM I---EA-------QQYQL------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP V----------------------------DL-------FQ---KIRQQVKCYLMTASTME ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR R---ER-------AKLFW--------DMKKT--------H---RAIDELQQ--------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP L---AY-------LKYLW--------SFGEE--------SKRQTAYRRLQY--------- SMG1_Smoe_SMG1 Y---EN-------SLLHF--------SEGQH--------A---KAMTELWP--------- GK008_Glam_FRAP Y---AY-------CKHLW--------VSSN------------ENVLEKLVA--------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP KNECMQGL-E--VIES----------------------------TN--LKYFTK------ SMG1_Hsap_SMG1 ------CA-I--SF---CK-----------------------------SV---------K FRAP_Hsap_FRAP ------FV-Q--TM---QQQ--A---------QH--------AIA---TEDQQH---KQE mei-41_Dmel_ATR ------QL-S--IMRS---G--CQG-NVK---------------------QLAA---EQR CG2905_Dmel_TRRAP KNEINEAL-E--VIES----------------------------TN--LKYFTG------ CG6535_Dmel_ATM ------VT-N--N---------------N----------------------------EFV CG4549_Dmel_SMG1 ------LC-L--NI---QK-----------------------------SN---------N FRAP_Mmus_FRAP ------FV-Q--TM---QQQ--A---------QH--------AIA---TEDQQH---KQE DNAPK_Mmus_DNAPK -----KTI-T--LLDE------------------------------------------SD ATR_Mmus_ATR ------GV-E--LCFP---E--N---------------------------KSPS---ESK ATM_Mmus_ATM ------MI-K--KL---DSS--FKD-KEN----------------------------DAG C47D12.1_Cele_TRRAP ------VR-I---------D------------------------------DLQK------ B0261.2_Cele_FRAP ------LA-N--HW---NKR--INP-IPKA------------T-GR--ELIPPS---TKE atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR TSDELNGM-S--LLDS----------------------------II--SKNFGDLHTIYT TEL1_Scer_ATM ------LL-A--QNEK---N--ISE-SI-----------------------L------YD MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------MI-K--KL---DAS--CAA---N----------------------------NPS ATR_Hsap_ATR ------GV-E--LCFP---E--N---------------------------ETPP---EGK DNAPK_Hsap_DNAPK -----KTV-S--LLDE------------------------------------------NN TOR_Dmel_FRAP ------FV-S--TY---SQE--LSC-LPPE------------A----------L---KQQ SMG1_Mmus_SMG1 ------CA-I--SF---CK-----------------------------SA---------K TRRAP_Mmus_TRRAP KNECMQGL-E--VIES----------------------------TN--LKYFTK------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------FT-S--RL---AHD--LGL-DPNNMIAQ--------SVKLSSASTAPY---VEE TOR2_Scer_FRAP ------FT-S--RM---AHD--LGL-DPNNMIAQ--------SVPQQSKRVPRH---VED TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------EL-K--NKWN---P--IIN-SNNNSSNNSSSNININNGSKLSLLG--L---PQE DNAPK_Ddis_DNAPK -----KAL-K--FIESKKDEESIIN-S-----------------N-------------EN SMG1_Ddis_SMG1 ------YAHR--DI---TI-------PSSST-----------TTTTTTTT---------T Tor_Ddis_FRAP ------FV-Q--AL---RDT---------------------------------------D TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------LI-D--KL---SKS--------Q----------------------------DSS ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -----KAL-D--HLGK------------------------------------------LP FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP KQELQEGL-E--VIES----------------------------TN--LKYFSR------ CC1G_00839_Ccin_ATM ------LL-M--KP---ASS------------------------------SLPA------ CC1G_08126_Ccin_ATR -----QSL-G--LISS----------------------------GN--VLDLTL---DDE CC1G_00894_Ccin_FRAP ------FT-A--SL---AKD--IQQ-ETNE------------Q-GHRPNVSKSK---LAE CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------TD-RMHTL---SL----------------------------------------- CC1G_00331_Ccin_TRRAP -SDLQIGL-E--VINN----------------------------TN--LMFFTA------ AqueK043_Aque_ATM -----------------ECH--------Q----------------------------E-- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP PSEIQEAF-D--FIES----------------------------TN--LKYFSK------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------VL-V--NVPL---S--VLG-TASGAAL---SGLVLNTSQTESALELTV---EEQ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------LA-L--DL---ANG--QASMYCTP------------Q-GASG------------ SMG1_Smoe_SMG1 ------LV-K--NF---IA-----------------------------ESERAL---PFE GK008_Glam_FRAP ------FT-HLIRL---CND--VS-----------------------------I---QKT GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP --EM-T-----AEFYALKGMFLAQIN-----------KSE-------------------- SMG1_Hsap_SMG1 AEYA-V-----AKSILTLAKWIQAEW-----------KEI-------------------- FRAP_Hsap_FRAP LHKL-M-----ARCFLKLGEWQLNLQ-----------G-I-------------------- mei-41_Dmel_ATR HLFF-R-----GKY--LQAVYSAESM-----------HLC-------------------- CG2905_Dmel_TRRAP --EM-N-----AEFYALKGLLLAQIG-----------RSE-------------------- CG6535_Dmel_ATM YCVQ-R-----VPALRMQGEFLLDCNAETLSWVQSHKFNN-------------------- CG4549_Dmel_SMG1 QPAA-G-----ADLLLNLADWIAVRT---------------------------------- FRAP_Mmus_FRAP LHKL-M-----ARCFLKLGEWQLNLQ-----------G-I-------------------- DNAPK_Mmus_DNAPK I----------SNYL----------------------------NKNIQASCDQSILLGTT ATR_Mmus_ATR HMLI-H-----GRATLLVGRFMEETA-----------NFE-------------------- ATM_Mmus_ATM LKVI-Y-----AECLRVCGSWLAETC-----------LEN-------------------- C47D12.1_Cele_TRRAP --DQ-V-----AALLYHRANIHSVLD---------------------------------- B0261.2_Cele_FRAP PARI-C-----AKVLLKLGEWTELKS-----------KTS-------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR D-TQ-Q-----SVNLDVQKSAKLKIE-----------HYQ-------------------- TEL1_Scer_ATM DFKL-LINVPMDQIKARLVKWSSESR-----------LEP-------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM LKLT-Y-----TECLRVCGNWLAETC-----------LEN-------------------- ATR_Hsap_ATR NMLI-H-----GRAMLLVGRFMEETA-----------NFE-------------------- DNAPK_Hsap_DNAPK V----------SSYL----------------------------SKNILAFRDQNILLGTT TOR_Dmel_FRAP DQRL-M-----ARCYLRMATWQNKLQ-----------DSI-------------------- SMG1_Mmus_SMG1 AEYA-V-----AKSILTLAKWVQAEW-----------KEI-------------------- TRRAP_Mmus_TRRAP --EM-T-----AEFYALKGMFLAQIN-----------KSE-------------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP YTKL-L-----ARCFLKQGEWRIATQ-----------PNW-------------------- TOR2_Scer_FRAP YTKL-L-----ARCFLKQGEWRVCLQ-----------PKW-------------------- TRA1_Scer_TRRAP -------------------------------------SAL-------------------- ATR_Ddis_ATR DLFI-I-----SKTHLLIARWKQQCG-----------ITH-------------------- DNAPK_Ddis_DNAPK L----------QKYLMMHGDIFWDIY-----------QLDKKLGSTLVIDSFKKN----- SMG1_Ddis_SMG1 TPPS-T-----SSNTA--TTTNNINI-----------DEL-------------------- Tor_Ddis_FRAP DLPL-Q-----GRAYLKLGEWQLALG-----------DTL-------------------- TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM HYKI-Y-----ATTLSIHGNWLAETR-----------SQS-------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK V----------SHNL----------------------------GSDLFLLCDHRILTSKT FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --EM-T-----AEFYALKGMFLAQVG-----------RSD-------------------- CC1G_00839_Ccin_ATM --PS-K-----AELYSRLGTWISEAY-----------LEK-------------------- CC1G_08126_Ccin_ATR VVNT-K-----HKLFLWRARWMSESG-----------RFD-------------------- CC1G_00894_Ccin_FRAP LTKL-L-----ARCYFKQGEWQMELK-----------DDW-------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K PLKLLC-----EDELARLSVWNNPLS-----------DPK-------------------- CC1G_00331_Ccin_TRRAP --AQ-K-----AEFHTLKGMFYARLG-----------RLD-------------------- AqueK043_Aque_ATM -GVA-Y-----PTVLTLYGNWLSETL-----------SER-------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP --EM-V-----SEFLALKGTFLIQYG-----------KSE-------------------- ATM_Smoe_ATM ----------------LAGKWLAQTR-----------SAS-------------------- ATR_Smoe_ATR VCND-A-----AKTLLLLGRWAHCTG-----------QKQ-------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 GDVM-A-----ATSCLKLGSWLQKRR-----------TEN-------------------- GK008_Glam_FRAP EPKL-V-----CRMLIRLGAWYSDLL-----------TPL-------------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ----------------------------------SGQLKQVYRAQHQQNFTGLSTLSKNI FRAP_Hsap_FRAP ----------------------------------N------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 -------------------------------------------------CNGLTTNQS-- FRAP_Mmus_FRAP ----------------------------------N------------------------- DNAPK_Mmus_DNAPK CRIMADALSREP-ACLSDLEE-NKVNSILTLSGSN------------------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ----------------------------------N----------------NMQVGELSF atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK YRIIANALSSEP-ACLAEIEE-DKARRILELSGSS------------------------- TOR_Dmel_FRAP ----------------------------------R------------------------- SMG1_Mmus_SMG1 ----------------------------------SGQLRQVYRAQQQQNLSGLSTLSRNI TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ----------------------------------R------------------------- TOR2_Scer_FRAP ----------------------------------R------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ---------SLP-INLTSIPI-NSLK---------------------------------- SMG1_Ddis_SMG1 ----------------------------------STQKFKVY------------------ Tor_Ddis_FRAP ----------------------------------S------------------------- TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK YQSMASALQEEKGEMLTRLSDAGKLDKLLSKAECQ------------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----------------------------------D------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------DFAGL------- GK008_Glam_FRAP ----------------------------------D----------------HKS------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 LTLIELPSVNTMEEEYP------------------------------------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------PVLIQLLDQLP------------------------------------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP VRQQVSPQYRTKESRTPE------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 LALIELPSANTVGEEHP------------------------------------------- TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 TEIIK------YLNSNP------------------------------------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K --------------------------------------KGMDFIGTTERT---------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------------CSMIGTISPSEGYVNIPVQDTVT--------SCSAIWNSIVNNC GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ----------------------------------RI--ESES---TVHIGVGEPD----- FRAP_Hsap_FRAP ---------------------------------ES-----------------TIP----- mei-41_Dmel_ATR -----------------------------------------------------AD----- CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM -----------------------------------------------------SL----- CG4549_Dmel_SMG1 ----------------------------------ECPLTCDS---SQPLAIPQAE----- FRAP_Mmus_FRAP ---------------------------------ES-----------------TIP----- DNAPK_Mmus_DNAPK ---------------------------------AE-----------------NTETVITG ATR_Mmus_ATR -----------------------------------------------------SN----- ATM_Mmus_ATM -----------------------------------------------------PA----- C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ---------------------------------TI-----------------AFE----- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM -----------------------------------------------------AA----- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----------------------------------------------------PA----- ATR_Hsap_ATR -----------------------------------------------------SN----- DNAPK_Hsap_DNAPK ---------------------------------SE-----------------DSEKVIAG TOR_Dmel_FRAP ---------------------------------PD-----------------AIQ----- SMG1_Mmus_SMG1 ----------------------------------RI--ESES---TVHIGVGEPD----- TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ---------------------------------NT-----------------NPD----- TOR2_Scer_FRAP ---------------------------------LS-----------------NPD----- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -----------------------------------------------------HS----- DNAPK_Ddis_DNAPK ----------------------------------------------------------DE SMG1_Ddis_SMG1 ----------------------------------SI-ITELS---SSNYSIPQEQ----- Tor_Ddis_FRAP ---------------------------------EA-----------------SIP----- TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM -----------------------------------------------------PN----- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ---------------------------------ES-----------------KPEKVCQS FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM -----------------------------------------------------PT----- CC1G_08126_Ccin_ATR -----------------------------------------------------GT----- CC1G_00894_Ccin_FRAP ---------------------------------AR-----------------NVE----- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM -----------------------------------------------------PL----- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM -----------------------------------------------------SH----- ATR_Smoe_ATR -----------------------------------------------------KE----- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 --------------------------------------LSEMDLTSGSG-GMILE----- GK008_Glam_FRAP DADASVCSTTYEATEHSAERLELSSASTLDKAVAK-----------------LVD----- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ---E---------------------------------------AN--------------- SMG1_Hsap_SMG1 ---F---------------------------------------IL--------------- FRAP_Hsap_FRAP ---K---------------------------------------VL--------------- mei-41_Dmel_ATR ---A---------------------------------------VL--------------- CG2905_Dmel_TRRAP ---E---------------------------------------AG--------------- CG6535_Dmel_ATM ---K---------------------------------------LI--------------- CG4549_Dmel_SMG1 ---R---------------------------------------MV--------------- FRAP_Mmus_FRAP ---K---------------------------------------VL--------------- DNAPK_Mmus_DNAPK LYQR---------------------------------------AF--------------- ATR_Mmus_ATR ---A---------------------------------------VM--------------- ATM_Mmus_ATM ---V---------------------------------------IM--------------- C47D12.1_Cele_TRRAP ---------------------------------------QAENAD--------------- B0261.2_Cele_FRAP ---N---------------------------------------TI--------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ---E---------------------------------------ETKNLFSSVQMLRISHM TEL1_Scer_ATM ---A---------------------------------------IY--------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ---V---------------------------------------IM--------------- ATR_Hsap_ATR ---A---------------------------------------IM--------------- DNAPK_Hsap_DNAPK LYQR---------------------------------------AF--------------- TOR_Dmel_FRAP ---G---------------------------------------AL--------------- SMG1_Mmus_SMG1 ---F---------------------------------------IL--------------- TRRAP_Mmus_TRRAP ---E---------------------------------------AN--------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ---A---------------------------------------IL--------------- TOR2_Scer_FRAP ---S---------------------------------------IL--------------- TRA1_Scer_TRRAP ---N---------------------------------------IL--------------- ATR_Ddis_ATR ---E---------------------------------------LT--------------- DNAPK_Ddis_DNAPK LFNS---------------------------------------TF--------------- SMG1_Ddis_SMG1 ---L---------------------------------------NP--------------- Tor_Ddis_FRAP ---H---------------------------------------II--------------- TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ---V---------------------------------------IM--------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK LFMK---------------------------------------SK--------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ---E---------------------------------------AN--------------- CC1G_00839_Ccin_ATM ---DIKTKYFDPAINLLLQAAVSYNSEIWRFGTMESSMRPNEERY--------------- CC1G_08126_Ccin_ATR ---P---------------------------------------LL--------------- CC1G_00894_Ccin_FRAP ---D---------------------------------------IL--------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ---E---------------------------------------AS--------------- AqueK043_Aque_ATM ---V---------------------------------------IL--------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ---E---------------------------------------AN--------------- ATM_Smoe_ATM ---V---------------------------------------IL--------------- ATR_Smoe_ATR ---D---------------------------------------VI--------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ---E---------------------------------------VA--------------- GK008_Glam_FRAP ---N---------ILLAYDELSNVSLEECNQYNTVGMSRIGLIAL--------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ----------KA----F--SA---------------------AV--Q------------- SMG1_Hsap_SMG1 ---------GQL----Y--HL---------------------SS--V------------- FRAP_Hsap_FRAP ----------QY----Y--SA---------------------AT--E------------- mei-41_Dmel_ATR ----------KY----F--QE---------------------AI--A------------- CG2905_Dmel_TRRAP ----------KS----F--SV---------------------AA--Q------------- CG6535_Dmel_ATM ----------DD----F--VQHRQTLSEKYRDIFDWHQ-L--DA--Y------------- CG4549_Dmel_SMG1 ---------ARL----V--HS---------------------CL--Q------------- FRAP_Mmus_FRAP ----------QY----Y--SA---------------------AT--E------------- DNAPK_Mmus_DNAPK ----------HH----L--SK---------------------AV--QSAE--EE------ ATR_Mmus_ATR ----------KK----Y--KD---------------------VT--L------------- ATM_Mmus_ATM ----------QT----Y--LEKAVK-------VAGSYD-GN-SR--E------------- C47D12.1_Cele_TRRAP ----------YT----F--SA---------------------AS--Q------------- B0261.2_Cele_FRAP ----------NY----Y--QQ---------------------AT--Q------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR IKAGNTIGFDKV----Y--HE---------------------TT--Q------------- TEL1_Scer_ATM ----------EKIIVNW--DI---------------------NV--E------------- MEC1_Scer_ATR ------------------------------------------AN--M------------- ATM_Hsap_ATM ----------QT----Y--LEKAVE-------VAGNYD-GESSD--E------------- ATR_Hsap_ATR ----------KK----Y--KD---------------------VT--A------------- DNAPK_Hsap_DNAPK ----------QH----L--SE---------------------AV--QAAE--EE------ TOR_Dmel_FRAP ----------EC----F--EK---------------------AT--S------------- SMG1_Mmus_SMG1 ---------GQL----Y--HL---------------------SS--V------------- TRRAP_Mmus_TRRAP ----------KA----F--SA---------------------AV--Q------------- smg-1_Cele_SMG1 ----------------F--HL---------------------AS--E------------- TOR1_Scer_FRAP ----------GS----Y--LL---------------------AT--H------------- TOR2_Scer_FRAP ----------GS----Y--LL---------------------AT--H------------- TRA1_Scer_TRRAP ----------QS----Y--KS---------------------DI--H------------- ATR_Ddis_ATR ----------EH----Y--SS---------------------AT--A------------- DNAPK_Ddis_DNAPK ----------KC----Y--SE---------------------SI--KLHQ--KSTNLLNT SMG1_Ddis_SMG1 ---------EYY----F--KK---------------------AT--L------------- Tor_Ddis_FRAP ----------SS----F--KA---------------------AT--E------------- TRRAP_Ddis_TRRAP ----------------LQIEL---------------------HDIFL------------- ATMa_Spur_ATM ----------ED----Y--LEKAKQ----------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ----------KY----L--DD---------------------AV--GTIKLDPA------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----------KT----F--SA---------------------AV--Q------------- CC1G_00839_Ccin_ATM ----------KI----A--SR---------------------AQ--H------------- CC1G_08126_Ccin_ATR ----------EA----F--KR---------------------AT--E------------- CC1G_00894_Ccin_FRAP ----------HS----Y--YY---------------------AT--H------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ----------------------------------------------I------------- CC1G_00331_Ccin_TRRAP ----------AA----F--GQ---------------------AV--Q------------- AqueK043_Aque_ATM ----------EE----Y--LEKAVS-------LLESQ------P--V------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ----------KC----F--SA---------------------AV--Q------------- ATM_Smoe_ATM ----------ES----Y--LEKAVI-------IAETRSTSSGSS--D------------- ATR_Smoe_ATR ----------SI----Y--TR---------------------VK--D------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ----------SS----G--VS---------------------PV--P------------- SMG1_Smoe_SMG1 ---------GAA----V--KA---------------------AT--L------------- GK008_Glam_FRAP ----------EW----F--QV---------------------AA--D------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------MHDV-------L SMG1_Hsap_SMG1 ------------------------------------------------QAPE-------V FRAP_Hsap_FRAP ------------------------------------------------HDRS-------W mei-41_Dmel_ATR ------------------------------------------------VHRQ-------S CG2905_Dmel_TRRAP ------------------------------------------------LHDG-------L CG6535_Dmel_ATM ------------------------------------------------ASKQ-------R CG4549_Dmel_SMG1 ------------------------------------------------QRPN-------Y FRAP_Mmus_FRAP ------------------------------------------------HDRS-------W DNAPK_Mmus_DNAPK ------------------------TQLSCWGHE---------------AAAE-------R ATR_Mmus_ATR ------------------------------------------------FLPE-------W ATM_Mmus_ATM ------------------------------------------------LRNG-------Q C47D12.1_Cele_TRRAP ------------------------------------------------LVDLQNSVTTTG B0261.2_Cele_FRAP ------------------------------------------------YDPG-------W atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------LLQCFAHSGVMY TEL1_Scer_ATM ------------------------------------------------DHES-------C MEC1_Scer_ATR --------------------------------ILCSLRFLITNFEKDKRHGS-------K ATM_Hsap_ATM ------------------------------------------------LRNG-------K ATR_Hsap_ATR ------------------------------------------------CLPE-------W DNAPK_Hsap_DNAPK ------------------------AQPPSWSCG---------------PAAG-------V TOR_Dmel_FRAP ------------------------------------------------YDPN-------W SMG1_Mmus_SMG1 ------------------------------------------------QAPE-------V TRRAP_Mmus_TRRAP ------------------------------------------------MHDV-------L smg-1_Cele_SMG1 ------------------------------------------------MCPS-------L TOR1_Scer_FRAP ------------------------------------------------FDKN-------W TOR2_Scer_FRAP ------------------------------------------------FDNT-------W TRA1_Scer_TRRAP ------------------------------------------------YRKS-------A ATR_Ddis_ATR ------------------------------------------------F--E-------W DNAPK_Ddis_DNAPK TSSSPSLSISSSSSPYSSTSSSSQPKLSNEILI---------------EKTK-------T SMG1_Ddis_SMG1 ------------------------------------------------TKPE-------N Tor_Ddis_FRAP ------------------------------------------------CDPN-------W TRRAP_Ddis_TRRAP ------------------------------------------------NLKE-------Q ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -----------------------SHSLSSSAKR---------------EEQS-------M FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------MHDT-------L CC1G_00839_Ccin_ATM ------------------------------------------------TAK-------KL CC1G_08126_Ccin_ATR ------------------------------------------------LDKR-------W CC1G_00894_Ccin_FRAP ------------------------------------------------YDPG-------W CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------LEAS-------W CC1G_00331_Ccin_TRRAP ------------------------------------------------LDMT-------Q AqueK043_Aque_ATM ------------------------------------------------NKDQ-------L AqueK044_Aque_ATR ---------------------------------------------------E-------N AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------LHDG-------L ATM_Smoe_ATM ------------------------------------------------FMKR-------R ATR_Smoe_ATR ------------------------------------------------LQPM-------W DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------LIAP-------W SMG1_Smoe_SMG1 ------------------------------------------------HCPS-------F GK008_Glam_FRAP ------------------------------------------------RDET-------S GK009_Glam_PIKK-Unclassified ------------------------------------------------YQKC-------L TRRAP_Hsap_TRRAP VKAW-------------------------------------------------------- SMG1_Hsap_SMG1 AKSWAAL------------------------AS-------WAYRWGRKVVDNAS---QGE FRAP_Hsap_FRAP YKAW-------------------------------------------------------- mei-41_Dmel_ATR ESCH-------------------------------------------------------- CG2905_Dmel_TRRAP TKAW-------------------------------------------------------- CG6535_Dmel_ATM TAAY-------------------------------------------------------- CG4549_Dmel_SMG1 AEALIAY------------------------GN-------WCYRWGKKVADSCCVLTQAD FRAP_Mmus_FRAP YKAW-------------------------------------------------------- DNAPK_Mmus_DNAPK AHAY-------------------------------------------------------- ATR_Mmus_ATR EDGH-------------------------------------------------------- ATM_Mmus_ATM MKAF-------------------------------------------------------- C47D12.1_Cele_TRRAP IKLM-------------------------------------------------------- B0261.2_Cele_FRAP HKVW-------------------------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR EAAW-------------------------------------------------------- TEL1_Scer_ATM SDVF-------------------------------------------------------- MEC1_Scer_ATR YKNI-------------------------------------------------------- ATM_Hsap_ATM MKAF-------------------------------------------------------- ATR_Hsap_ATR EDGH-------------------------------------------------------- DNAPK_Hsap_DNAPK IDAY-------------------------------------------------------- TOR_Dmel_FRAP YKAW-------------------------------------------------------- SMG1_Mmus_SMG1 AKSWAAL------------------------AS-------WAYRWGRKVVDNAS---QGE TRRAP_Mmus_TRRAP VKAW-------------------------------------------------------- smg-1_Cele_SMG1 AKAHLKM------------------------AR-------WAYEIAKIK----------- TOR1_Scer_FRAP YKAW-------------------------------------------------------- TOR2_Scer_FRAP YKAW-------------------------------------------------------- TRA1_Scer_TRRAP YKYL-------------------------------------------------------- ATR_Ddis_ATR EKGF-------------------------------------------------------- DNAPK_Ddis_DNAPK KSAH-------------------------------------------------------- SMG1_Ddis_SMG1 SKLWITY------------------------AD-------WILNEKSNIS---------- Tor_Ddis_FRAP YKAW-------------------------------------------------------- TRRAP_Ddis_TRRAP IKCYLQLPTHYDTGISIINSTNLDFFTPMQKGEFLQLKGEFLNRLG-------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK AKAH-------------------------------------------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP VKAW-------------------------------------------------------- CC1G_00839_Ccin_ATM LEAD-------------------------------------------------------- CC1G_08126_Ccin_ATR ESSH-------------------------------------------------------- CC1G_00894_Ccin_FRAP YKAW-------------------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K -----------------------------------VHHAETAAIRD-------------- CC1G_13883_Ccin_PI4K AKVI-------------------------------------------------------- CC1G_00331_Ccin_TRRAP AKVW-------------------------------------------------------- AqueK043_Aque_ATM LHAY-------------------------------------------------------- AqueK044_Aque_ATR EEGH-------------------------------------------------------- AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP YKAW-------------------------------------------------------- ATM_Smoe_ATM SKTH-------------------------------------------------------- ATR_Smoe_ATR EKGY-------------------------------------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP GKAW-------------------------------------------------------- SMG1_Smoe_SMG1 GKAWFSY------------------------AS-------WCYSLARCGFFGNE------ GK008_Glam_FRAP NHIW-------------------------------------------------------- GK009_Glam_PIKK-Unclassified VTAL-------------------------------------------------------- TRRAP_Hsap_TRRAP -----------------------------------------------A-----MWGDYLE SMG1_Hsap_SMG1 GVRL----------------------------LPREKSEVQNLLPDT------------- FRAP_Hsap_FRAP -----------------------------------------------H-----AWAVMNF mei-41_Dmel_ATR -----------------------------------------------V-----QMAQFLE CG2905_Dmel_TRRAP -----------------------------------------------A-----MWGDYME CG6535_Dmel_ATM -----------------------------------------------A-----TIAKYAD CG4549_Dmel_SMG1 ATAI---------------------SQALDIPQPLESEKLDELLQAL------------- FRAP_Mmus_FRAP -----------------------------------------------H-----AWAVMNF DNAPK_Mmus_DNAPK -----------------------------------------------M-----TLVGFCD ATR_Mmus_ATR -----------------------------------------------F-----YLAKYYD ATM_Mmus_ATM -----------------------------------------------L-----SLARFSD C47D12.1_Cele_TRRAP -----------------------------------------------KNWGHHLYKRFFS B0261.2_Cele_FRAP -----------------------------------------------H-----KLASTHF atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -----------------------------------------------L-----L--DYLS TEL1_Scer_ATM -----------------------------------------------Y-----TLGSFLD MEC1_Scer_ATR -----------------------------------------------N-----NWTDDQE ATM_Hsap_ATM -----------------------------------------------L-----SLARFSD ATR_Hsap_ATR -----------------------------------------------F-----YLAKYYD DNAPK_Hsap_DNAPK -----------------------------------------------M-----TLADFCD TOR_Dmel_FRAP -----------------------------------------------H-----LWAYMNF SMG1_Mmus_SMG1 GVRL----------------------------LPREKSEVQNLLPDT------------- TRRAP_Mmus_TRRAP -----------------------------------------------A-----MWGDYLE smg-1_Cele_SMG1 ---NFPAEN---------------LSFYKFGK---DETENEELLKSLE-----ATSLVNL TOR1_Scer_FRAP -----------------------------------------------H-----NWALANF TOR2_Scer_FRAP -----------------------------------------------H-----NWALANF TRA1_Scer_TRRAP -----------------------------------------------T---------CVR ATR_Ddis_ATR -----------------------------------------------F-----FLGRYYD DNAPK_Ddis_DNAPK -----------------------------------------------L-----KFANFCD SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -----------------------------------------------H-----SWALINF TRRAP_Ddis_TRRAP ----RYDEA---------------NQSFASS-----VSQYENSAKNWI-----SWAHFCD ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -----------------------------------------------M-----ALVSFCD FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----------------------------------------------A-----LWGDYLE CC1G_00839_Ccin_ATM -----------------------------------------------KALAE-------- CC1G_08126_Ccin_ATR -----------------------------------------------F-----YFGNFYD CC1G_00894_Ccin_FRAP -----------------------------------------------H-----TWALANF CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ----RIMKEMISLEEERMARMQEGDGA--------------------------------- CC1G_13883_Ccin_PI4K -----------------------------------------------R-----T----IW CC1G_00331_Ccin_TRRAP -----------------------------------------------A-----EWGRYND AqueK043_Aque_ATM -----------------------------------------------L-----SLARYSD AqueK044_Aque_ATR -----------------------------------------------F-----CLGRYYD AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -----------------------------------------------A-----LWGDFLD ATM_Smoe_ATM -----------------------------------------------F-----HLAHFAN ATR_Smoe_ATR -----------------------------------------------F-----YMARYYD DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -----------------------------------------------H-----RWALFNT SMG1_Smoe_SMG1 --TL---------------------SKASIFPQVLE-KELISS-SPS------------- GK008_Glam_FRAP -----------------------------------------------K-----CISHTTY GK009_Glam_PIKK-Unclassified -----------------------------------------------S-----AWMLVVC TRRAP_Hsap_TRRAP NI-------------------------------------------------------FVK SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP EA-------------------------------------------------------VLH mei-41_Dmel_ATR KI-------------------------------------------------------LEA CG2905_Dmel_TRRAP QI-------------------------------------------------------FLK CG6535_Dmel_ATM RE-------------------------------------------------------YQQ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP EA-------------------------------------------------------VLH DNAPK_Mmus_DNAPK QQ-------------------------------------------------------LRK ATR_Mmus_ATR KL-------------------------------------------------------MPM ATM_Mmus_ATM TQ-------------------------------------------------------YQR C47D12.1_Cele_TRRAP TT-------------------------------------------------------V-- B0261.2_Cele_FRAP YA-------------------------------------------------------VCR atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR NY---------------------------------------------------------- TEL1_Scer_ATM EQ-------------------------------------------------------AQK MEC1_Scer_ATR QA-------------------------------------------------------F-Q ATM_Hsap_ATM TQ-------------------------------------------------------YQR ATR_Hsap_ATR KL-------------------------------------------------------MPM DNAPK_Hsap_DNAPK QQ-------------------------------------------------------LRK TOR_Dmel_FRAP KV-------------------------------------------------------VQA SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP SI-------------------------------------------------------FVK smg-1_Cele_SMG1 EK-------------------------------------------------------LVR TOR1_Scer_FRAP EV-------------------------------------------------------ISM TOR2_Scer_FRAP EV-------------------------------------------------------ISM TRA1_Scer_TRRAP RL-------------------------------------------------------SEE ATR_Ddis_ATR SL-------------------------------------------------------LSN DNAPK_Ddis_DNAPK NI-------------------------------------------------------LKD SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP EV-------------------------------------------------------VSH TRRAP_Ddis_TRRAP NQ-------------------------------------------------------FTN ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK QL-------------------------------------------------------LRQ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP QI-------------------------------------------------------FCK CC1G_00839_Ccin_ATM ---------------------------------------------------------S-- CC1G_08126_Ccin_ATR AS-------------------------------------------------------AKD CC1G_00894_Ccin_FRAP EV-------------------------------------------------------ISH CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K QV-------------------------------------------------------DPA CC1G_00331_Ccin_TRRAP QR-------------------------------------------------------FKE AqueK043_Aque_ATM NQ-------------------------------------------------------FRR AqueK044_Aque_ATR RL-------------------------------------------------------LTL AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP QL-------------------------------------------------------FAV ATM_Smoe_ATM AL-------------------------------------------------------HRS ATR_Smoe_ATR DL-------------------------------------------------------LVD DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP AA-------------------------------------------------------LSH SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP AI-------------------------------------------------------VNS GK009_Glam_PIKK-Unclassified SLTKLLAYNAQLLMDSNEKNKVSVSFLTSSLLYFAPATDFCLCMDKHQKVAGTIIELIEG TRRAP_Hsap_TRRAP ER---------------------------------------------------------- SMG1_Hsap_SMG1 ---I-----------------TEE---------------------------EKERI---Y FRAP_Hsap_FRAP YKHQN----Q-----------ARD---------------------------EKKKL---R mei-41_Dmel_ATR RQGGK----S------------E------------------------------------- CG2905_Dmel_TRRAP ER---------------------------------------------------------- CG6535_Dmel_ATM LHDYR----HSQEYQTLKDIIEQ----------------------------NRQTAEKVT CG4549_Dmel_SMG1 ---S-----------------TEQ---------------------------PPANC---V FRAP_Mmus_FRAP YKHQN----Q-----------ARD---------------------------EKKKL---R DNAPK_Mmus_DNAPK VEESA----S------------QK-----------------------------T------ ATR_Mmus_ATR VTDNK----M------------E------------------------------------- ATM_Mmus_ATM IENYM----KSSEFENKQTLLKR----------------------------AKEEVGLLR C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ERPHPTTVIS---------PPQQP---------------------------QQPKK---M atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR KE---------------------------------------------------------- TEL1_Scer_ATM LRSNG----E------------IEDREHRSYTGKSTLKALELIYKNTKLPENERKD-AKR MEC1_Scer_ATR KK---------------------------------------------------------- ATM_Hsap_ATM IENYM----KSSEFENKQALLKR----------------------------AKEEVGLLR ATR_Hsap_ATR VTDNK----M------------E------------------------------------- DNAPK_Hsap_DNAPK EEENA----S------------VI-----------------------------D------ TOR_Dmel_FRAP QKSAL----------------DKQ---------------------------Q-PPG---A SMG1_Mmus_SMG1 ---I-----------------TEE---------------------------EKERI---Y TRRAP_Mmus_TRRAP ER---------------------------------------------------------- smg-1_Cele_SMG1 AAIS-------------------------------------------------------- TOR1_Scer_FRAP VQEET----K------------LN---------------------------GGKN----- TOR2_Scer_FRAP LTSVS----K-----------KKQ---------------------------EGSD----- TRA1_Scer_TRRAP PN---------------------------------------------------------- ATR_Ddis_ATR LKRVN----Q------------N----------------------------SPN------ DNAPK_Ddis_DNAPK KISQQ----T------------TP-----------------------------T------ SMG1_Ddis_SMG1 ----------------------EQ---------------------------NDE------ Tor_Ddis_FRAP YEQNG------------------------------------------------------- TRRAP_Ddis_TRRAP HSSS-------------------------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK QDDDD----C------------NP-----------------------------D------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP DK---------------------------------------------------------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR LKPT-------------------------------------------------------- CC1G_00894_Ccin_FRAP IDTLA----E-----------NRA---------------------------TDIPG---D CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K VAIFF----Q-----------ERF----------------------------QYAG---V CC1G_00331_Ccin_TRRAP NP---------------------------------------------------------- AqueK043_Aque_ATM ISDHM----NSPLYQAKQKLLDR----------------------------AKTDLQSMS AqueK044_Aque_ATR V----------------------------------------------------------- AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP DK---------------------------------------------------------- ATM_Smoe_ATM YEDRL----GSTEWQTELQLRNMK---------------------------MKEYEALVR ATR_Smoe_ATR ARKRQ----E------------E----------------------------NKEHR---S DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP YSMKG------------------------------------------------------- SMG1_Smoe_SMG1 ---L-----------------TDE---------------------------EMMKI---Q GK008_Glam_FRAP FAAYI----D-----------KLN----------------------------DRPG---V GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 GIL-------------------------------------------GQAVCRPAGIQDED FRAP_Hsap_FRAP HASGANITNATTAATTAATATTTASTEGS------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ---QRENQDRRVIS---------------------------------------------- CG4549_Dmel_SMG1 EVC-------------------------------------------P------------- FRAP_Mmus_FRAP HASGANITNATTAATTAASAAAATSTEGS------------------------------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ---EHKIQ------TNRYT----------------------------------------- C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP HI--PPVTRATSPPPPAQK----------------------------------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM H----------------------------------------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ---EHKIQ------TNRYT----------------------------------------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP SM--G------------------------------------------------------- SMG1_Mmus_SMG1 GIL-------------------------------------------GQAVCRPAGIQDED TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP D----------------------------------------------------------- TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP SL--A------------------------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -----------------------RHEVGR------------------------------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ---KAKPD-GRSTEFPKHY----------------------------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM KAKESKDD------THGYSLK--------------------------------------- ATR_Smoe_ATR N----------------------------------------------------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 AMI---------------------KSLGSELEDAILEMLVKRVVFLLEAAAREAGFEK-- GK008_Glam_FRAP DG-GLQI------VTRRSSVDATSDAVGS------------------------------- GK009_Glam_PIKK-Unclassified -------------------------TIGS------------------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ITLQITESEDN--EEDDMVDVIWRQLISS------CPWL--------------------- FRAP_Hsap_FRAP ----------NS-ESE-AESTE------N------SPTP--------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ---DAARA-----RDDEAAK----NRLRR------LTFL--------------------- FRAP_Mmus_FRAP ----------NS-ESE-AESNE------N------SPTP--------------------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP -----------------------------------SPQPAPFHSITEPLSVIIDYPVPPP atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------M----------------- SMG1_Mmus_SMG1 ITLQITESEDN--EDDDMVDVIWRQLISS------CPWL--------------------- TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 -------------DD--------------------------------------------- TOR1_Scer_FRAP -----------D-DDDTAVNND------NVRIDGSILGS--------------------- TOR2_Scer_FRAP -----------A-SSVT----D------INEFDNGMIGV--------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ESLNGGGSGGNENSSNEML----------------------------------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------S----------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ----------LV-RTG-TTSV--------------LDVP--------------------- CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 -------------WDGESLSLQLRQE------------L--------------------- GK008_Glam_FRAP ----------TS-EAL-SQSVQ------D------SDRP--------------------- GK009_Glam_PIKK-Unclassified ----------GAG----------------------------------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ---------------------------S----EL---------DESA----TEGVIKVWR FRAP_Hsap_FRAP ---------------------------S----PL---------QKKV----TED------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ----------------------------------VQMKRYASLDEQQ----LNQ------ CG4549_Dmel_SMG1 ---------------------------A----DK---------TPEA----LDAILQIWR FRAP_Mmus_FRAP ---------------------------S----PL---------QKKV----TED------ DNAPK_Mmus_DNAPK ----------------------------------------------S------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ----------------------------------VKVQRELELDECA----LRA------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP LGSLVGLPPMPAYLSSNSSLPPQHHHVS----PL-------SNDSPS----NSA------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ---------------------------------YNRVLLQYNRDSEV----LKA------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ----------------------------------VKVQRELELDELA----LRA------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ----------------------------------------------S------------- TOR_Dmel_FRAP -----------------------------------------TMGS-G----LDS------ SMG1_Mmus_SMG1 ---------------------------S----EL---------DENA----TEGVIKVWR TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ---------------------------------L---------RANNILAPNSHFMHIWK TOR1_Scer_FRAP ---------------------------G----SL---------TING----NRY------ TOR2_Scer_FRAP ---------------------------N----TF---------DAKE----VHY------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -------------------------------------------SPPL------------- DNAPK_Ddis_DNAPK ---------------------------------------------QF------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP -----------------------------------------------------G------ TRRAP_Ddis_TRRAP ----------------------------------------------------SITPSSTP ATMa_Spur_ATM ----------------------------------------LPIDKKX----VEC------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ---------------------------------------------YL------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP -----------------------------------------HVVQ-A----VTG-----K CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ---------------------------EALLVLL-------GD-RLD----PAV------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ----------------------------------RQLSKLSEEDELI----IRQ------ AqueK044_Aque_ATR ----------------------------------------------------EK------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ---------------------------------ALEVQKELKLESVE----WTK------ ATR_Smoe_ATR ---------------------------------TTK------RGSNA------------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ---------------------------Q----VL---------KPSSVPGLINELLQVWW GK008_Glam_FRAP ---------------------------LVCPEHL-------GFVQNR----QVL------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP --------Q----LHLGVSAITCYLHACRH------------------------QNESKS SMG1_Hsap_SMG1 KVVDR---I----FSLYKLSCSAYFTFLKLNAGQIPLDEDDPRLHLSH-RVEQSTDD-MI FRAP_Hsap_FRAP -LSKT---L----LMYTVPAVQGFFRSISL------------------------SRG-NN mei-41_Dmel_ATR -PTGE---Q----DDMLINVMVNYAKSLRY------------------------GS-EHV CG2905_Dmel_TRRAP --------K----ITLAVDALICYLQASRN------------------------QIESKT CG6535_Dmel_ATM -IEEK---L----TEYLRLALTNYMAYCRL------------------------DSG-FS CG4549_Dmel_SMG1 RAIAN---T----YDYYKDAARSYFQYLSFKSGSGPEKPEGEGV-VSQRERLHVDDS-NL FRAP_Mmus_FRAP -LSKT---L----LLYTVPAVQGFFRSISL------------------------SRG-NN DNAPK_Mmus_DNAPK ---AE---M----EAYPALVVEKMLRALKL------------------------NS-SEA ATR_Mmus_ATR ----K---Q----GDLIRYIVLHFGRSLQY------------------------GN-QFI ATM_Mmus_ATM -LRED---R----KRFLCKAVENYINCLLS------------------------GEE-H- C47D12.1_Cele_TRRAP -CKET---G----NNFGRQALACYFIAARV------------------------DND-IK B0261.2_Cele_FRAP -ENKL---Y----LKHAAHAVRCFAKALMC------------------------SPG-SR atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR --------R----SKHVLPLLKAYKEVAKY------------------------EKNQVL TEL1_Scer_ATM -LLLQ---K----EKFLWHALHFYLNTLVF------------------------SN-RYD MEC1_Scer_ATR ----L---Q------DNILGIFQVFSSDIH------------------------DVEGRT ATM_Hsap_ATM -LKED---R----KRFLCKAVENYINCLLS------------------------GEE-H- ATR_Hsap_ATR ----K---Q----GDLIRYIVLHFGRSLQY------------------------GN-QFI DNAPK_Hsap_DNAPK ---AE---L----QAYPALVVEKMLKALKL------------------------NS-NEA TOR_Dmel_FRAP -DLMI---I----QRYAVPAVQGFFRSISL------------------------IKG-NS SMG1_Mmus_SMG1 KVVDR---I----FSLYKLSCSAYFTFLKLNAGQVLLDEDDPRLHLSH-RAEQSTDD-VI TRRAP_Mmus_TRRAP --------Q----LHLGVSAITCYLHACRH------------------------QNESKS smg-1_Cele_SMG1 MVRDH---R----TKFLSIAVTSYFQFIQNMSGDCDN-------------LPYSKKE-ET TOR1_Scer_FRAP -PLEL---I----QRHVVPAIKGFFHSISL------------------------LET-SC TOR2_Scer_FRAP -SSNL---I----HRHVIPAIKGFFHSISL------------------------SES-SS TRA1_Scer_TRRAP --------N----ISFASNAISCYLQAAGL------------------------YKNSKI ATR_Ddis_ATR -DSVS---Y----VDYTRNIISSYGQAVIL------------------------GH-SYI DNAPK_Ddis_DNAPK --NEE---V----IDLATSVIVSTLEAIKE------------------------EI-PGS SMG1_Ddis_SMG1 RLKNT---N----TNELKTAVEAYFQFLKYSML-----------------DGNSNGG-LN Tor_Ddis_FRAP -TPEQ---I----GAHLLPAVHSFFKSISL------------------------GPD-RS TRRAP_Ddis_TRRAP TTYDI---K----TQWAESAISCYIQGIKCDP------------------------K-YG ATMa_Spur_ATM -LRED---R----QTFLARAMECYLHCLEA------------------------SDQ-SQ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ---PL---M----EAYPSTVVNSTLQAMNL------------------------NS-PEA FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --------Q----MSLGESAITCFLHACRH------------------------QNESKS CC1G_00839_Ccin_ATM -HEST---Q----KKFLLQALKMYSRCLQV------------------------TNK-YD CC1G_08126_Ccin_ATR --DAR---R----LKMNMHMLRNYSRATRY------------------------GT-KFI CC1G_00894_Ccin_FRAP PPFVA---V----LDAMLILGKGFFRSISL------------------------RNQ-DA CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -RKDL---RHLLLWAPVPPIIANTFFERRY------------------------NNDPML CC1G_00331_Ccin_TRRAP ----A---D----LTLAASAVSCYLQAAGL------------------------YKCGKS AqueK043_Aque_ATM -HEQD---Q----RQFLNKSIINYSLC--------------------------------- AqueK044_Aque_ATR -NPSN---Y----ADVLNYTIKHYGDALTY------------------------GN-RFI AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP --------N----ITLAVSALTCFLHACRH------------------------QSEPKS ATM_Smoe_ATM -MHGD---M----ARVLRTCLKSYRSCLLS------------------------SDK-YD ATR_Smoe_ATR -DDKP---W----WTYLPDTVLCYAKTLHR------------------------SH-HHL DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -DSVK---A----AHHVVSAVSGYFKSIANAST-------------------NKGGD-DS SMG1_Smoe_SMG1 GVRKR---R----ISLFGYAAHGFLKYMSLSNRTT-------------VRSNPLKQD-ST GK008_Glam_FRAP -LEKA---K----LEYLVESIIAHFKCIET------------------------GRSIEA GK009_Glam_PIKK-Unclassified ----AASDE-----QKGIPGVEAHVLN--------------------------------- TRRAP_Hsap_TRRAP R-KYLA-K--VLWLLSFDDDK--------------------------------------- SMG1_Hsap_SMG1 V-MATL-RLLRLLVKHAG--E--------------------------------------- FRAP_Hsap_FRAP L-QDTL-RVLTLWFDYGHW----------------------------------------- mei-41_Dmel_ATR Y-QSMP-RLISLWLDTTESSTN----------------TEQV------------------ CG2905_Dmel_TRRAP R-KYIA-K--VLWFLSYDNNT--------------------------------------- CG6535_Dmel_ATM S-AAIY-RIISLWFTNATS----------------------------------------- CG4549_Dmel_SMG1 V-TTTL-RLLRLIVKHAS--G--------------------------------------- FRAP_Mmus_FRAP L-QDTL-RVLTLWFDYGHW----------------------------------------- DNAPK_Mmus_DNAPK R-LKFP-RLLQIIEQYSEE----------------------------------------- ATR_Mmus_ATR Y-QSMP-RMLSLWLDFGAKAYEWE----KGGRSDRLQMRNDL------------------ ATM_Mmus_ATM D-LWVF-RLCSLWLENSGV----------------------------------------- C47D12.1_Cele_TRRAP A-RK-P-IAKILWLSKHLNA------------------CGSH------------------ B0261.2_Cele_FRAP L-EDTL-RLMQLWFDHGDDKD--------------------------------------- atm-1_Cele_ATM -----------------------------------------D------------------ atl-1_Cele_ATR QARAVE-RMTSLWLSNTRKISTHISSVPKLPEGQISDLRQNI------------------ TEL1_Scer_ATM N-DIID-KFCGLWFENDD-----------------------N------------------ MEC1_Scer_ATR T-YYEKLRV--------------------------------------------------- ATM_Hsap_ATM D-MWVF-RLCSLWLENSGV----------------------------------------- ATR_Hsap_ATR Y-QSMP-RMLTLWLDYGTKAYEWE----KAGRSDRVQMRNDL------------------ DNAPK_Hsap_DNAPK R-LKFP-RLLQIIERYPEE----------------------------------------- TOR_Dmel_FRAP L-QDTL-RLLTLWFDYGNH----------------------------------------- SMG1_Mmus_SMG1 V-MATL-RLLRLLVKHAG--E--------------------------------------- TRRAP_Mmus_TRRAP R-KYLA-K--VLWLLSFDDDK--------------------------------------- smg-1_Cele_SMG1 T-LATL-RILELLVKHGD--V--------------------------------------- TOR1_Scer_FRAP L-QDTL-RLLTLLFNFGGI----------------------------------------- TOR2_Scer_FRAP L-QDAL-RLLTLWFTFGGI----------------------------------------- TRA1_Scer_TRRAP R-ELLC-R--ILWLISIDDAS--------------------------------------- ATR_Ddis_ATR Y-QTLT-RIIALWCELGVIFSDFK----IPEKSTK-VTSDSL------------------ DNAPK_Ddis_DNAPK V-DKFP-RLLEILTQFEQY----------------------------------------- SMG1_Ddis_SMG1 I-RATL-KILNILVCSGN--K--------------------------------------- Tor_Ddis_FRAP L-QDTL-RLLTLWFKHGAQ----------------------------------------- TRRAP_Ddis_TRRAP S-RYVP-RIFWLLYLNGSGEV--------------------PQQIQTQQQQQQAAAQGGL ATMa_Spur_ATM D-TRVF-RLCSLWEN-GTD----------------------------------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK R-QHFP-RLLQLVEKYP-D----------------------------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP R-KYLA-K--VLWLITYDDEK----------------AD--------------------- CC1G_00839_Ccin_ATM T-EASI-KFASLWLSNFD--------------------EDQG------------------ CC1G_08126_Ccin_ATR Y-QTIP-RLLTVWLDNGEDKNIF--------------GTDVF------------------ CC1G_00894_Ccin_FRAP L-QDTL-RLLTLWFKYGHH----------------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K L-Q--------------------------------------------------------- CC1G_00331_Ccin_TRRAP R-PLLM-RVLYLLSLDN-DA---------------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR Y-HCLP-RALSLWLDYGNSSASK---------QEKALLQSNV------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP -------RLLTLWFDYGHI----------------------------------------- AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP R-KYLA-R--TIWILSYDDEK--------------------------------------- ATM_Smoe_ATM M-RVVF-RLVSLWFGNVEN----------------------------------------- ATR_Smoe_ATR F-QALP-RLLTLWFEFGSAYRSES-----LG-SNK-IVKAAH------------------ DNAPK_Smoe_DNAPK -----A-RLISMAGH--------------------------------------------- FRAP_Smoe_FRAP L-QDIL-RLLTLWFNHGAS----------------------------------------- SMG1_Smoe_SMG1 L-SASL-FVLNILQTCGV--E--------------------------------------- GK008_Glam_FRAP L-PTTL-RLMTLWFRYGSY----------------------------------------- GK009_Glam_PIKK-Unclassified -------FLLALGLDTL-ITE-------------------A------------------- TRRAP_Hsap_TRRAP ----------N-TLADAVDKYCIGV-PPIQWLAWIPQLLTCLV-G-SE----G------- SMG1_Hsap_SMG1 -------------LRQYLEHGLETT-PTAPWRGIIPQLFSRLN-H-PE----V---Y--V FRAP_Hsap_FRAP ----------P-DVNEALVEGVKAI-QIDTWLQVIPQLIARID-T-PR----P---L--V mei-41_Dmel_ATR ----------K-KMNDLLTNCCTAL-PTAVFYTVYSQMLSRLC-H-PV----ND-----V CG2905_Dmel_TRRAP ----------K-ILISTLEKHVAGI-PPSYWLPWIPQLLCCLE-Q-FE----G------- CG6535_Dmel_ATM ----------K-QCQECIKDEILTV-PSYKFICAANQLTARLN-S-KN----T---S--L CG4549_Dmel_SMG1 -------------LQEVLEQGLHTT-PIAPWKVIIPQLFSRLN-H-HE----P---Y--V FRAP_Mmus_FRAP ----------P-DVNEALVEGVKAI-QIDTWLQVIPQLIARID-T-PR----P---L--V DNAPK_Mmus_DNAPK -------------TLNIMTKEISSI-PCWQFIGWISHMMALLD-K-EE----A------- ATR_Mmus_ATR ----------A-KINSVLTEHTNRL-APYQFLTAFSQLISRIC-H-SH----DE-----V ATM_Mmus_ATM ----------S-EVNGMMKKDGMKI-SSYKFLPLMYQLAARMG-T-KM----TGGLG--F C47D12.1_Cele_TRRAP ----------E-VMNRVIKKQLHSL-NLFNWLYWLPQLVTDVR-Y-KP----NSN----- B0261.2_Cele_FRAP ----------Q-DVYFALTETIFDL-PVTTWLEAIPQLMARLD-C-PD----DQ--K--S atm-1_Cele_ATM ----------VGVIALLKEHTKSKL-PSKLWISATSHIASKCF-S-IEKSQITRH----- atl-1_Cele_ATR ----------K-SMNREIQTALEHI-GWRAFYPAYAVLARHID-H-QD----EE-----V TEL1_Scer_ATM ----------S-KINQLLYKEIGTI-PSWKFLPWVNQIASKIS-M-EE----NE-----F MEC1_Scer_ATR --------------INGISFLIIYA-PKKSIISALAQISICLQ-T-GL----GL------ ATM_Hsap_ATM ----------S-EVNGMMKANGMKI-PTYKFLPLMYQLAARMG-T-KM----MGGLG--F ATR_Hsap_ATR ----------G-KINKVITEHTNYL-APYQFLTAFSQLISRIC-H-SH----DE-----V DNAPK_Hsap_DNAPK -------------TLSLMTKEISSV-PCWQFISWISHMVALLD-K-DQ----A------- TOR_Dmel_FRAP ----------A-EVYEALLSGMKLI-EINTWLQVIPQLIARID-T-HR----Q---L--V SMG1_Mmus_SMG1 -------------LRQYLEHGLETT-PTAPWRGIIPQLFSRLN-H-PE----V---Y--V TRRAP_Mmus_TRRAP ----------N-TLADAVDKYCIGV-PPIQWLAWIPQLLTCLV-G-SE----G------- smg-1_Cele_SMG1 -------------LIDVINDGLNKT-NVHIWKEILPQLFARLS-H-PS----E---H--I TOR1_Scer_FRAP ----------K-EVSQAMYEGFNLM-KIENWLEVLPQLISRIH-Q-PD----P---T--V TOR2_Scer_FRAP ----------P-EATQAMHEGFNLI-QIGTWLEVLPQLISRIH-Q-PN----Q---I--V TRA1_Scer_TRRAP ----------G-MLTNAFDSFRGEI-PVWYWITFIPQLLTSLS-H-KE----A------- ATR_Ddis_ATR ----------E-SIKKAMSKLELDV-PASNWLMFLSQVASRIC-H-KN----TD-----T DNAPK_Ddis_DNAPK ----------S-VIAREFKSRVSTI-PCWMFIRWISQMFPYLD-L-PQ----G------- SMG1_Ddis_SMG1 -------------LVETFERCLNELTSTRPFTIIIPQLFARLS-H-PD----T---F--V Tor_Ddis_FRAP ----------K-EVEAALMQGFNTI-SIDTWLHVIPQIIARIH-A-PV----L---P--V TRRAP_Ddis_TRRAP PPQPRKLTPAQ-SVFQSFLNSWTIL-PQWIWLNYMPQLISGAA-N-LL----N---FPGY ATMa_Spur_ATM ----------V-QISLLLEDTIGKI-ESRKFLPMMYQLAARMT-T-KV----QGKEQ--F ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -------------TMQSLVKKASII-PSWMFIGWISQMVALLD-K-PE----S------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----------H-PLAKAVDKYSVGV-PPIQWLPWIPQLLTCLV-G-NE----G------- CC1G_00839_Ccin_ATM ----------P-EIVEAIGEALEKI-PSHKFVFLAHQLSARIT-K-SP----SQQTK--N CC1G_08126_Ccin_ATR ----------N-KMNEVVASAIKDI-PAYKWFTAFPQIVSRVC-H-PV----DK-----V CC1G_00894_Ccin_FRAP ----------D-EVSHSMANGFSTV-EVDTWLEVIPQIIARIQ-T-PH----A---N--I CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K -------------------------------FVTVPQMSETSG-S------------SKT CC1G_13883_Ccin_PI4K ----------------YANRVMAQH-PVELTFFFIPQVVQALR-Y-DD----L---V--R CC1G_00331_Ccin_TRRAP ----------L-IIGRSFDGYKGDA-AFWYWIALVPQLCVSLS-H-KE----NK------ AqueK043_Aque_ATM ---------------LSTGDYVSSL-PSYKLLPVIYQLAARMS-S-LN----S--DP--F AqueK044_Aque_ATR ----------D-KITKLMENLVDQL-APYQFLIAFSQIISRVC-H-HD----DN-----V AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ----------S-EVHEALEEGIKTV-DIENWLQVIPQLIARID-S-PR----R---L--V AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ----------R-TLAEALDKYYMGI-PPMHWLPWIPQLLTCLV-R-NE----G------- ATM_Smoe_ATM ----------K-TVINDMIETVHKV-PSFKFLPLVYQIASRMG-A-IK----T-AND--F ATR_Smoe_ATR ----------V-RVMAIMRGCLQEL-PSYQWLASLPQLVSRIC-H-DN----EE-----V DNAPK_Smoe_DNAPK ----------Q-EIQAIFSARIDKV-PSWIFLGWLPQLLALMD-S-RE----G------- FRAP_Smoe_FRAP ----------D-EVYAALQDGFKHV-IIDTWLVVLPQIIARIH-S-HI----P---A--V SMG1_Smoe_SMG1 -------------LEDILQQGLSSI-PPSPWKEITPQLFACVSSH-PE----A---K--V GK008_Glam_FRAP ----------D-EVETEIINGLAAV-PINIWLDVIPQLIARLH-S-PQ----H---K--I GK009_Glam_PIKK-Unclassified ----------N-EKLTEIIEGSPAI-LLQNQFHNICSMVIRLC-DTKI----N---L--I TRRAP_Hsap_TRRAP -KLLLNL---ISQVGRVYPQAVYFP--------IRTLYLTLK--------IEQRERYKSD SMG1_Hsap_SMG1 RQSICNL---LCRVAQDSPHLILYP--------AIVGTISLS--------SESQASGNKF FRAP_Hsap_FRAP GRLIHQL---LTDIGRYHPQALIYP--------LTVASKSTT--------TARHNA---- mei-41_Dmel_ATR FTVLRNV---IIKLVEAYPQQSLWM--------LLPHFKSAK--------AHRIKRCKLV CG2905_Dmel_TRRAP -DVILNL---LSQIGRLYPQAVYFP--------IRTLYLTLK--------IEQREKHKTA CG6535_Dmel_ATM LKGLTDL---LVQCGKDHPYHTFYQ--------LYPLVFAHL--------DGENSN---- CG4549_Dmel_SMG1 RKSVCDL---LCRLAKSRPQLVIFP--------AVVGANREQ--------QDATAPPAT- FRAP_Mmus_FRAP GRLIHQL---LTDIGRYHPQALIYP--------LTVASKSTT--------TARHNA---- DNAPK_Mmus_DNAPK -IAVQHT---VEEIADNYPQAIIYP--------FIISSESYS--------FKNTSSGHNN ATR_Mmus_ATR FVVLMEI---IAKVFLAYPQQAMWM--------MTAVSKSSY--------PMRVNRCKEI ATM_Mmus_ATM HEVLNNL---ISRISLDHPHHTLFI--------ILALANANK--------DEFLSKPE-T C47D12.1_Cele_TRRAP ---FVLI---LCKMAAAHPLQVFYH--------IREAVSVDD--------IDSVLEEDYT B0261.2_Cele_FRAP VQLVLRV---LCEIARHRPQAVIYA--------LTVASRSKD--------VHRSKN---- atm-1_Cele_ATM ---LSQI---LCHLIYDYPYHVLHT--------ILMYDDEK------------------- atl-1_Cele_ATR TRTIKQI---MKQLILRMPHQCMWQ--------SAYLLRQNI--------ASVKEK---- TEL1_Scer_ATM QKPLQLT---MKRLLYKLPYDSLYS--------VMSILLYEKQSNKDTNISQKIQAVKKI MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM HEVLNNL---ISRISMDHPHHTLFI--------ILALANANR--------DEFLTKPE-V ATR_Hsap_ATR FVVLMEI---IAKVFLAYPQQAMWM--------MTAVSKSSY--------PMRVNRCKEI DNAPK_Hsap_DNAPK -VAVQHS---VEEITDNYPQAIVYP--------FIISSESYS--------FKDTSTGHKN TOR_Dmel_FRAP GQLIHQL---LMDIGKNHPQALVYP--------LTVASKSAS--------LARRNA---- SMG1_Mmus_SMG1 RQSICNL---LCRVAQDSPHLILYP--------AIVGTISLS--------SESQASGNKY TRRAP_Mmus_TRRAP -KLLLNL---ISQVGRVYPQAVYFP--------IRTLYLTLK--------IEQRERYKSD smg-1_Cele_SMG1 RKTLVDL---ISKICTAAPHAVVFQ--------VVSGAASSS--------TDGEELEEQQ TOR1_Scer_FRAP SNSLLSL---LSDLGKAHPQALVYP--------LTVAIKSES--------VSRQKA---- TOR2_Scer_FRAP SRSLLSL---LSDLGKAHPQALVYP--------LMVAIKSES--------LSRQKA---- TRA1_Scer_TRRAP -NMVRHI---LIRIAKSYPQALHFQ--------LRTTKEDFA--------VIQRQTMAVM ATR_Ddis_ATR WLILEKI---IIRTMIEFPKQSIWI--------MMMQYRSSS--------SIRKQRARTC DNAPK_Ddis_DNAPK -PLILPI---LLEIAKWYPQAIYFP--------FKISSEQFG--------PLAKKI---- SMG1_Ddis_SMG1 QKYVVEI---LNRIGRDNPNKIVYQ--------TIVGSLNFT--------NTNNNNNSS- Tor_Ddis_FRAP RRLLHEL---IDTIGKEHPQALVYP--------LTVATKSHS--------PARLAA---- TRRAP_Ddis_TRRAP GFLCWQM---IGKICYLFPNSSYYH--------FRKLVLEMK--------SNASK---FT ATMa_Spur_ATM YTILNAL---IERVAADHPHHALPV--------ILALANANL--------DTVINSKKTK ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -LAVQGI---LKAIAKDYPQALVYP--------FKISSEDFK--------LGDKSKEKQR FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -DLIINI---LMQVGRVYPQALYFP--------IRTLYLTHK--------IEHREKLIPT CC1G_00839_Ccin_ATM QTDLQRL---ILRLCLEHPFHSVYQ--------VYSLQADDD--------LSTLGSQKE- CC1G_08126_Ccin_ATR YNLVSQL---IVSIIQEYPDQALWL--------FAGVIKSTK--------HNRLTRGRVI CC1G_00894_Ccin_FRAP RRNINNL---LTDVGKHHPQALIYP--------LTVASKSSS--------SARRTA---- CC1G_06302_Ccin_PI3K ---------------------------------------AAS--------EQRSSR---- CC1G_04234_Ccin_PI4K LEDESII---RKELNKVDPSAVVFS--------ESWAAK--------------------- CC1G_13883_Ccin_PI4K LGYVARFIFETAKISQLFCHQIIWN--------MKANCYKDD------------------ CC1G_00331_Ccin_TRRAP --PARYI---LLNLAKHFPQGIFYH--------LRTTREELQ--------VVKKAIAAKA AqueK043_Aque_ATM QHILQEM---LYRLGKDHPYHSLYV--------ILALSNAGI--------DNEFPQKGYV AqueK044_Aque_ATR YATLEKI---ILILLKHYPQHSLWL--------MIAVSKSSL--------TV-------- AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP SKLIHEL---LTDVGRHHPQALIYP--------LTVAAKSQS--------TVRRDA---- AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP -SHILNL---LCSVGKAYPQAIYFP--------IRTLYLTLK--------IEQKEKFKAE ATM_Smoe_ATM QFAVASL---VKKMAIEHPYHSLYQ--------LLALANGDR--------IKENQK---- ATR_Smoe_ATR VRLVKQI---IQSVLQAYPQQALWT--------MAAVSKSDI--------PERRSAATEI DNAPK_Smoe_DNAPK -GLFIGI---LESIAQHFPQALFFP--------FHVSKDQYG--------TVGLDR---- FRAP_Smoe_FRAP RELIQQL---LVRIGQIHPQALMYP--------LLVACKSIS--------SSRKTA---- SMG1_Smoe_SMG1 RKQLEGL---LMSLANVYPWAIVYP--------TLVHFNASE--------GQSSEE---- GK008_Glam_FRAP RLLVHQL---LVLIGTEHPQALIYP--------LVVASKSTI--------LNRRVE---- GK009_Glam_PIKK-Unclassified AVEYSSM---SVDVMKNHILNVIAKKLIPYSAHFDIAIRQFG--------V--------- TRRAP_Hsap_TRRAP --------------------------------------------------SGQ------- SMG1_Hsap_SMG1 STAIPTLLGNIQGEELLVSECEGGSPPASQDSNKDEPKSGLNED---------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR --------------------------------------------------LTD------- CG2905_Dmel_TRRAP --------------------------------------------------E-Q------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 --ARP------------------------------------------------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK --------------------------------------------------KAF------- ATR_Mmus_ATR --------------------------------------------------LTK------- ATM_Mmus_ATM --------------------------------------------------TRR------- C47D12.1_Cele_TRRAP --------------------------------------------------DEQ------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM --------------------------------------------------LLE------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM --------------------------------------------------ARR------- ATR_Hsap_ATR --------------------------------------------------LNK------- DNAPK_Hsap_DNAPK --------------------------------------------------KEF------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 SSAIPTLLGNIQGEELLVSECEGGSPPASQDSNKDEPKSGLNED---------------- TRRAP_Mmus_TRRAP --------------------------------------------------SGQ------- smg-1_Cele_SMG1 -----------------------------------------NDD---------------- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP --------------------------------------------------G-D------- ATR_Ddis_ATR --------------------------------------------------LEK------- DNAPK_Ddis_DNAPK ---------------------------------------------------SA------- SMG1_Ddis_SMG1 -CAAATTDDGLDIELL--------------------------QK---------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP -----------------------------------------TSPP--------------- ATMa_Spur_ATM --------------------------------------------------LG-------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK --------------------------------------------------KDA------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------------------------------------KTLTTADTTTPSDATPS CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR --------------------------------------------------LEK------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --------------------------------------------------AQQ------- AqueK043_Aque_ATM --------------------------------------------------TGQ------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP --------------------------------------------------VHS----SHP ATM_Smoe_ATM ---------------------------------------------------RK------- ATR_Smoe_ATR --------------------------------------------------IQA------- DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------Q-QPSSVG---------------- SMG1_Hsap_SMG1 ---------Q---------------------AMM-------------------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ---------------------S--------------------RL---------------- CG2905_Dmel_TRRAP ------------------------------------A-VKSSCS---------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ---------T---------------------TED-------------------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ----------------------VE------------R-IKSKLD---------------- ATR_Mmus_ATR ---------------------A--------------------IH---------------- ATM_Mmus_ATM ---------------------S--------------RITKSTSK---------------- C47D12.1_Cele_TRRAP --------------------------------------MSMDVS---------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ---------------------L--------------------QG---------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ---------------------S--------------RITKNVPK---------------- ATR_Hsap_ATR ---------------------A--------------------IH---------------- DNAPK_Hsap_DNAPK ----------------------VA------------R-IKSKLD---------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ---------Q---------------------AMM-------------------------- TRRAP_Mmus_TRRAP ------------------------------------Q-QPSSAG---------------- smg-1_Cele_SMG1 ---------R---------------------NRV-------------------------- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------K-PD--TN---------------- ATR_Ddis_ATR ---------------------A--------------------RK---------------- DNAPK_Ddis_DNAPK ------------------------------------P-LEKEL----------------- SMG1_Ddis_SMG1 ---------Q---------------------YPN-------------------------- Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ---TTKTTAT---------------------TTT-------------------------- ATMa_Spur_ATM ------------------------------------RSSGGDL----------------- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ----------------------VK------------E-IEDILS---------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP NTA---------TVSKEDTKEDVDAKK-ETSSTTTTA-APTTAGGDATTSTTTPSTTSTT CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ---------------------A--------------------KS---------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --------------------QALE------------A-S---RR---------------- AqueK043_Aque_ATM ---------------------R--------------RSNGGAMS---------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP PPPFLRSTSQPGTPNPPSASDGVEPMQVDSAH---------SLGKPPD--SQVPPQ--TP ATM_Smoe_ATM ---------------------N--------------AF---------------------- ATR_Smoe_ATR ---------------------A--------------------KF---------------- DNAPK_Smoe_DNAPK ---------------------------------------TRKL----------------- FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -----------------------N-----------------QS-------------HSAS SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -----------------------Q------------------N-S--------------- CG2905_Dmel_TRRAP -----------------------N-----------------ID-GTTLSFGRGASHGNIP CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK -----------------------H------------------G-E--------------- ATR_Mmus_ATR -----------------------M------------------K-K--------------- ATM_Mmus_ATM -----------------------EN----------------------------------- C47D12.1_Cele_TRRAP -----------------------D-----------------ED-------------CFAD B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM -----------------------Y-----------------DR-G--------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----------------------QS----------------------------------- ATR_Hsap_ATR -----------------------M------------------K-K--------------- DNAPK_Hsap_DNAPK -----------------------Q------------------G-G--------------- TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP -----------------------N-----------------QS-------------HSAS smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP -----------------------D------------------------------------ ATR_Ddis_ATR -----------------------T------------------D-A--------------- DNAPK_Ddis_DNAPK -----------------------I------------------N-P--------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP --------TATATITTATTTSTPT-----------------QNTTPTQNTTTPIKEESST ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -----------------------T------------------V-P--------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP SDS-TSTTTTTTTPS-TSTPAP-G-----------------LG-------------ASVT CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR -----------------------S------------------P-S--------------- CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -----------------------A------------------SVD--------------- AqueK043_Aque_ATM -----------------------NGTKLRRSGGGAGGRGGGV------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP TESEAKQPKPPSTPGATVPPLPSG-----------------DS-------------SMPS ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -----------------------S------------------T-R--------------- DNAPK_Smoe_DNAPK -----------------------A------------------A-T--------------- FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP DPGPIR------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR -----T------------------------------------------------------ CG2905_Dmel_TRRAP SINPIK------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK -----V------------------------------------------------------ ATR_Mmus_ATR -----S------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP D----------------------------------------------------------- B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM -----A------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -----S------------------------------------------------------ DNAPK_Hsap_DNAPK -----V------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP DPGPIR------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ----RN------------------------------------------------------ ATR_Ddis_ATR -----I------------------------------------------------------ DNAPK_Ddis_DNAPK -----L------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP TTATTTPAVPSTSTPTSTSAPAPISTSTNTPPNATTTTPQANTTSPPPPSSTFSP----- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -----L------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP NPGPIR------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR -----S------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -----ASGDVAMADGTGTPSTEGNPPPAQTPAISTPAQPQAQPQNPPQPRASPAPPAVGG AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ESAPFR------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -----N------------------------------------------------------ DNAPK_Smoe_DNAPK -LKSPL------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP --ATAPMW----------R-CSRIMHMQRELHP---TLLSSLEGIVDQMV---------- SMG1_Hsap_SMG1 -------Q---------DC-YSKIVDKLSSANP---TMVLQVQMLVAELRRV------TV FRAP_Hsap_FRAP --------------------ANKILKNMCEHSN---TLVQQAMMVSEELIRV------AI mei-41_Dmel_ATR --------------------F-----------Q---KLLQDFNSLTERLM---------- CG2905_Dmel_TRRAP --ATPPMW----------R-CSKVMQLQREVHP---TILSSLEGIVDQMV---------- CG6535_Dmel_ATM -------------TERSGI-ARKIIAMICEKNGTAGECSKQLESLLPALITF------AN CG4549_Dmel_SMG1 -------A---------CC-YGYLLGELSKQAP---EAVQHVKLMVKELRRV------CL FRAP_Mmus_FRAP --------------------ANKILKNMCEHSN---TLVQQAMMVSEELIRV------AI DNAPK_Mmus_DNAPK -------------------------------IH---SFINALDQLSNPDL---------- ATR_Mmus_ATR --------------------L-----------E---KFVGDATRLTDKLL---------- ATM_Mmus_ATM ---------SHLDEDRTEA-ATRIIHSIRSKRC---KMVKDMEALCDAYIIL------AN C47D12.1_Cele_TRRAP ----PP--------------FDRILKICLKYRP---TDIRVFHRVLKELDEM------NE B0261.2_Cele_FRAP --------------------AGTVLEKMMEYHS---KLVREASLVTEELVRC------AI atm-1_Cele_ATM -------------------------------------------------NAS------KV atl-1_Cele_ATR --------------------YMEVLTEVKRKAP---CYV--------------------- TEL1_Scer_ATM --------------------FA----------K---KYLLPVQEFCEMSV---------- MEC1_Scer_ATR KEVRYEAF---------RCWHLLVRHLNDEE----------LSTVIDSLIA--------- ATM_Hsap_ATM ---------SQLDEDRTEA-ANRIICTIRSRRP---QMVRSVEALCDAYIIL------AN ATR_Hsap_ATR --------------------L-----------E---KFVGDATRLTDKLL---------- DNAPK_Hsap_DNAPK -------------------------------IQ---DFINALDQLSNPEL---------- TOR_Dmel_FRAP --------------------AFKILDSMRKHSP---TLVEQAVMCSEELIRV------AI SMG1_Mmus_SMG1 -------Q---------DC-YSKIVDKLSSANP---TMVLQVQMLVAELRRV------TV TRRAP_Mmus_TRRAP --ATAPMW----------R-CSRIMHMQRELHP---TLLSSLEGIVDQMV---------- smg-1_Cele_SMG1 -------R---------AC-CEKLETNMSQSYP---NLVKDVRQFVAELERI------NL TOR1_Scer_FRAP --------------------ALSIIEKIRIHSP---VLVNQAELVSHELIRV------AV TOR2_Scer_FRAP --------------------ALSIIEKMRIHSP---VLVDQAELVSHELIRM------AV TRA1_Scer_TRRAP --GRRQPW---------EY-LQELNNILKTAYP---LLALSLESLVAQIND--------- ATR_Ddis_ATR --------------------KKN---------------QDETILLCAQLL---------- DNAPK_Ddis_DNAPK -------------------------------LD---TLVIEFQRLTHPEH---------- SMG1_Ddis_SMG1 -------Y---------LQ-ILNIKENLLKHSE---LLVKETETLIYQLGKL------TT Tor_Ddis_FRAP --------------------AKSLMDKMRKHSA---TLVDQALPVSQELVRT------AI TRRAP_Ddis_TRRAP -------L---------KM-TETLSLGLHQYHS---CLINEIDMMLGSFSILSGSIPAVY ATMa_Spur_ATM ---------SQTDKDRMQA-AVGMRDRLMAKTP-CCDIIPAMNKLS-------------- ATR_Spur_ATR -------------------------------------FTKDAIKLTDRLL---------- DNAPK_Spur_DNAPK -------------------------------VE---NLTLALQRLTHPGF---------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --ASVPMV----------R-CSKIMGVQRDLHP---ILLSSLEGIVDQMV---------- CC1G_00839_Ccin_ATM -----------------------RRQSTRSQAA---TLGSQVES---QIE--------RS CC1G_08126_Ccin_ATR --------------------SARI--------S---RLISDLHVMANEML---------- CC1G_00894_Ccin_FRAP --------------------AIQIMERMKDHSS---TIVTQALLVSKELIRV------AI CC1G_06302_Ccin_PI3K --------------------TTTSAISYDDSGL---TDFLIARGVRNPIMGN------RL CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K --------------------AAEIEDPMKP------------------------------ CC1G_00331_Ccin_TRRAP SEATRAAW---------EY-VDEILQILKTAFP---LLILSLETVVDQIQH--------- AqueK043_Aque_ATM -------GQCVVDDEKVKA-AQDLLSRLRSVNG---ELLRDISSLCEAYVDM------AY AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------EFIAALEQLNSPEL---------- AqueK046_Aque_FRAP --------------------ADMILSNMREHSS---DLVQQAVMVSEELIRV------AI AqueK047_Aque_SMG1 -------D---------RC-LAVIVDSLTQKNP---IMVKAVRDLVSELCRI------TL AqueK048_Aque_TRRAP --APASLW----------R-CSRIMHLLRDLHP---TLLSALEGIVDQLI---------- ATM_Smoe_ATM ----------VIDLEKKRA-AEELLKELTNRHS---NLIMQVRDMVEVYIKL------AE ATR_Smoe_ATR --------------------DDER--------A---TFVQFAT-FIEHMV---------- DNAPK_Smoe_DNAPK -------------------------------FE---GLVRALEDLTFPEK---------- FRAP_Smoe_FRAP --------------------ALTVVDRVRQHHV---ALVEQAQLVSQELIRV------AI SMG1_Smoe_SMG1 --------------------LERILNSLSKLHP---KVVNDVRLMIAELGSI------TF GK008_Glam_FRAP --------------------SLSIVDQIRRTNE---AMILESLNINKELQRV------AI GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP W-FRENWH-EEVLRQ--L---------Q----Q---GLAKCYS---VAF----------- SMG1_Hsap_SMG1 L-WDELWL-GVLLQQ--H------------------------M---YVL----------- FRAP_Hsap_FRAP L-WHEMWH-EGLEEA--S------------------------R---LYF----------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP W-FRESWT-EEVLRQ--L---------R----Q---GLIKCYA---IAF----------- CG6535_Dmel_ATM E-GKTND----------------------------------------------------- CG4549_Dmel_SMG1 L-WDEYWI-HSLAHI--Y------------------------N---TYV----------- FRAP_Mmus_FRAP L-WHEMWH-EGLEEA--S------------------------R---LYF----------- DNAPK_Mmus_DNAPK L-FKD-WV-SDTKDE--L---------G----K---NP----------V----------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM M-DASQW----------------------------------------------------- C47D12.1_Cele_TRRAP -----TWV-ERHLRH--AI------CLKDQMFK---DFSEQMD---ATFNEMQY------ B0261.2_Cele_FRAP L-WHEQWH-DALDDA--S------------------------R---VYF----------- atm-1_Cele_ATM -----KGF-LKTIFD--ARADQRDSSKLKEIVI---TIREAHQ---A-YREIAMLDVRGN atl-1_Cele_ATR ----------------------------------------------TLI----------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR FILQK-WS-E-------------------------------------------------- ATM_Hsap_ATM L-DATQW----------------------------------------------------- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK L-FKD-WS-NDVRAE--L---------A----K---TP----------V----------- TOR_Dmel_FRAP L-WHEQWH-EGLEEA--S------------------------R---LYF----------- SMG1_Mmus_SMG1 L-WDELWL-GVLLQQ--H------------------------M---YVL----------- TRRAP_Mmus_TRRAP W-FRENWH-EEVLRQ--L---------Q----Q---GLAKCYS---VAF----------- smg-1_Cele_SMG1 L-NEEKWS-VVMGTM--E------------------------H---EME----------- TOR1_Scer_FRAP L-WHELWY-EGLEDA--S------------------------R---QFF----------- TOR2_Scer_FRAP L-WHEQWY-EGLDDA--S------------------------R---QFF----------- TRA1_Scer_TRRAP R-FKSTTD-EDLFRL--I---------NVLLID---GTLNYNR---LPF----------- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK R-FKD-YM-EEMKSL--I---------K----A---TP----------K----------- SMG1_Ddis_SMG1 L-WDDNWQ-YFIEQI--Q------------------------G---WVY----------- Tor_Ddis_FRAP L-WLEMWY-EGLEEA--S------------------------R---QYF----------- TRRAP_Ddis_TRRAP Q-FNGSLN-QILLEA--------------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK I-FKD-WV-SVINSK--M---------N----S---KK----------R----------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP W-FRENWY-EEVLRH--L---------R----L---ALAKCQA---VAF----------- CC1G_00839_Ccin_ATM -----EAA-QDVL----------------------------------------------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP L-WHEMWH-EGLEEA--S------------------------R---LYF----------- CC1G_06302_Ccin_PI3K Y-WYLMVE-VALEDRVMA------------------------KMYGRVV----------- CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP K-FKPQPE-EEV------------------------------------------------ AqueK043_Aque_ATM H-DVTAH----------------------------------------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK A-WKD-WYDNELKPL--V---------G----SVTVPK----------R----------- AqueK046_Aque_FRAP L-WHEQWH-ETLEDA--S------------------------R---MYF----------- AqueK047_Aque_SMG1 L-WDEMWL-AALMQR--Q------------------------G---EVH----------- AqueK048_Aque_TRRAP W-FRESWY-EDLLRQ--L---------N----E---GLVACYE---EAF----------- ATM_Smoe_ATM L-EVSQQ----------------------------------------------------- ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK R-LFD-GL-CEVKSC--L---------M----S---GN----------R----------- FRAP_Smoe_FRAP L-WHEMWY-EALEEA--S------------------------R---LYF----------- SMG1_Smoe_SMG1 L-WEEQWL-TTLQDL--H------------------------A---DVT----------- GK008_Glam_FRAP L-WPEIAY-DLITQA--S------------------------T---AFC----------- GK009_Glam_PIKK-Unclassified --HMNRDY-SLEEEA--L------------------------R---HPV----------- TRRAP_Hsap_TRRAP -----EKSGAV---------------SDA---------KITPHTLNFVKKLVS------- SMG1_Hsap_SMG1 -----R----RIQQLEDEVKRVQ---NNNTLRKEEKIAIMRE------------------ FRAP_Hsap_FRAP -----GE----------------------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -----EKRDTV---------------QHS---------TITPHTLHFVKKLGS------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 -----S----RVSALATDFR------------PDDH-EGKNN------------------ FRAP_Mmus_FRAP -----GE----------------------------------------------------- DNAPK_Mmus_DNAPK -----NK----------------------------------------------------- ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ---SED---------------------------------VTMMTLRWRKQLEEDLVYFQQ B0261.2_Cele_FRAP -----HR---RLQ----------------------------D------------------ atm-1_Cele_ATM VRIQ-------------------------------------RVE---------------- atl-1_Cele_ATR -----DQY---------------------------------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK -----NK----------------------------------------------------- TOR_Dmel_FRAP -----GD----------------------------------------------------- SMG1_Mmus_SMG1 -----R----RIQQLEDEVKRVQ---NNNTLRKEEKIAIMRE------------------ TRRAP_Mmus_TRRAP -----EKSGAV---------------SDA---------KITPHTLNFVKKLVS------- smg-1_Cele_SMG1 -----K----RLSLIRTENAKTE---SALHLTASVKNDIIVK------------------ TOR1_Scer_FRAP -----VE----------------------------------------------------- TOR2_Scer_FRAP -----GE----------------------------------------------------- TRA1_Scer_TRRAP -----PRKNPK--------------------------------LPE-------------- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -----DL----------------------------------------------------- SMG1_Ddis_SMG1 -----I----NTKQWNDDYQQLKATIKNPTIL----KHTLKK------------------ Tor_Ddis_FRAP -----GD----------------------------------------------------- TRRAP_Ddis_TRRAP -----F----KLNKI--------------------------------------------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK -----DH----------------------------------------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----ENRGAV---------------VEA---------KVTPHTLSFVKKLVN------- CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP -----ND----------------------------------------------------- CC1G_06302_Ccin_PI3K -----F----KFMNK--------------------------------------------- CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK -----DK----------------------------------------------------- AqueK046_Aque_FRAP -----GE----------------------------------------------------- AqueK047_Aque_SMG1 -----R----RLLQIEAETKRTFA-IHNHVLSMERKEAVMRQ------------------ AqueK048_Aque_TRRAP -----ENRGDI---------------ASV---------RIKPEMFQYVQKLVS------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP -----GE----------------------------------------------------- SMG1_Smoe_SMG1 -----R----RIITLKEEAARIA---ENQTLSPDEKTKINAA------------------ GK008_Glam_FRAP -----EE----------------------------------P------------------ GK009_Glam_PIKK-Unclassified -----FN----------------------------------------------------- TRRAP_Hsap_TRRAP TFG-VGLEN--V-S---N-VS-TMFSSA--ASE-------SL-------------AR-RA SMG1_Hsap_SMG1 -------------KHTAL-MK-PIVFALE-HVR-------SI-------------TA-A- FRAP_Hsap_FRAP -------------R---N-VK-GMFEVLE-PLH-------AM-------------ME-RG mei-41_Dmel_ATR -----------------------------DLT---------------------------- CG2905_Dmel_TRRAP TFG-IGIEN--V-P---GSVTSSISNSA--ASE-------SL-------------AR-RA CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 -------------RFNVW-RP-QLLADLE-ALV-------AV-------------TS-R- FRAP_Mmus_FRAP -------------R---N-VK-GMFEVLE-PLH-------AM-------------ME-RG DNAPK_Mmus_DNAPK -------------K---N-IE-KLYERMYAALG-------DL-------------RA-PG ATR_Mmus_ATR -----------------------------ELC---------------------------- ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP NYN----------------L--DFLEIRN-KRK-------MI-------------VT-KG B0261.2_Cele_FRAP -------------N---N-VQ-AMFDALR-NMN-------DL-------------MQ-KG atm-1_Cele_ATM ---------------------------IN-GK---------------------------- atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM -----------------------------ELA---------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -----------------------------ELC---------------------------- DNAPK_Hsap_DNAPK -------------K---N-IE-KMYERMYAALG-------DP-------------KA-PG TOR_Dmel_FRAP -------------R---N-VK-GMFEILE-PLH-------AM-------------LE-RG SMG1_Mmus_SMG1 -------------KHTAL-MK-PIVFALE-HVR-------SI-------------TA-A- TRRAP_Mmus_TRRAP TFG-VGLEN--V-S---N-VS-TMFSSA--ASE-------SL-------------AR-RA smg-1_Cele_SMG1 -------------RTQLL-TR-QIFDVLD-ELY-------QQ-------------TVIE- TOR1_Scer_FRAP -------------H---N-IE-KMFSTLE-PLH-------KH-------------LG-NE TOR2_Scer_FRAP -------------H---N-TE-KMFAALE-PLY-------EM-------------LK-RG TRA1_Scer_TRRAP ------------------------------NTE-------KN-------------LV-KF ATR_Ddis_ATR -----------------------------AVS---------------------------- DNAPK_Ddis_DNAPK -------------N---A-IA-KLNNEIYDDSFN-------P-------------ST--V SMG1_Ddis_SMG1 -------------KNQEL-LQ-PIYEKLK-RLT-------AA-------------TVLS- Tor_Ddis_FRAP -------------H---N-PE-AMLATLA-PLH-------QI-------------LE-KG TRRAP_Ddis_TRRAP -------------------ED-SIYNSIR-SLY-------KH-------------YFVN- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR -----------------------------DLC---------------------------- DNAPK_Spur_DNAPK -------------L---A-IK-EEYQQLYQQLFESGGRQGEP-------------SS-SS FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP TFGGVGIEN--V-S---S-VT-QTLSSA--ASE-------LL-------------VR-RA CC1G_00839_Ccin_ATM --------------------------------Y-------R--------------LE-QG CC1G_08126_Ccin_ATR -----------------------------ALC---------------------------- CC1G_00894_Ccin_FRAP -------------K---N-PE-GMIMALE-PLH-------KL-------------LE-KG CC1G_06302_Ccin_PI3K ----------------------------------------IL-------------EA-E- CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -----------------------------------------K-------------LD-EM CC1G_00331_Ccin_TRRAP ------------------------YRNVCMLM---------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK -------------N---A-IK-RVWEQMYSQLL-------ETRSGLGDKSLYGGSPS-LQ AqueK046_Aque_FRAP -------------H---N-VQ-GMFKVLD-PLH-------QK-------------LD-KG AqueK047_Aque_SMG1 -------------KYIAT-MK-PLLWVLE-YLA-------AV-------------TA-Q- AqueK048_Aque_TRRAP SFGI-TAEQSNMTP---G-AA-GTGNNS--SQE-------AL-------------TK-RA ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -----------------------------RLC---------------------------- DNAPK_Smoe_DNAPK -------------T---K-AR-ETFRAVFADCLDVEAMR-NE-------------TR--Q FRAP_Smoe_FRAP -------------H---N-KE-GMLNVLE-PLH-------RK-------------LE-EE SMG1_Smoe_SMG1 -------------KYAAI-MA-PVSYALE-RRL-------TL-------------TS-R- GK008_Glam_FRAP -------------R---D-LV-KFFNYAC-QLQ-------LL-------------AS-RT GK009_Glam_PIKK-Unclassified -------------S---L-IK-RIFAVLE-A-H-------EV----------------Y- TRRAP_Hsap_TRRAP -QATA------Q-DPVFQKL---KG----------------QFTTDF-----D------- SMG1_Hsap_SMG1 PAETP------HEKWFQDNY---GD----------------AIENAL-----E------- FRAP_Hsap_FRAP -PQTL------KETSFNQAY---GR----------------DLMEAQ-----E------- mei-41_Dmel_ATR -----------N-KEVTL------------------------------------------ CG2905_Dmel_TRRAP -QVTF------Q-DPVFQKM---KE----------------QFTNDF-----D------- CG6535_Dmel_ATM -----------N------------------------------------------------ CG4549_Dmel_SMG1 PPETT------YERSFRKRF---DA----------------PIRLTV-----D------- FRAP_Mmus_FRAP -PQTL------KETSFNQAY---GR----------------DLMEAQ-----E------- DNAPK_Mmus_DNAPK -LGPF------R-RRFIQAF---GK----------------EFVK--------------- ATR_Mmus_ATR -----------N-KSVDG------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP -CMGVEKSQIMFEKELSQVF---TEPAGMQDEFDFVTNMTNMMVSQL-----D------- B0261.2_Cele_FRAP APTTM------KEHSFQQTY---SS----------------DLKEAG-----R------- atm-1_Cele_ATM ----------------------------TMYRWP-------------------------- atl-1_Cele_ATR ---DY------A-SGVFNTV---SG----------------KVESD-------------- TEL1_Scer_ATM -----------N-LKFVQ------------------------------------------ MEC1_Scer_ATR ------------------FN---G------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR -----------N-KPVDG------------------------------------------ DNAPK_Hsap_DNAPK -LGAF------R-RKFIQTF---GK----------------EFDK--------------- TOR_Dmel_FRAP -PQTL------KETSFSQAY---GR----------------ELTEAY-----E------- SMG1_Mmus_SMG1 PAETP------HEKWFQDNY---GD----------------AIDNAL-----E------- TRRAP_Mmus_TRRAP -QATA------Q-DPVFQKL---KG----------------QFTTDF-----D------- smg-1_Cele_SMG1 PPKSK------NEEEFVTAF---AE----------------VLTNAF-----Q------- TOR1_Scer_FRAP -PQTL------SEVSFQKSF---GR----------------DLNDAY-----E------- TOR2_Scer_FRAP -PETL------REISFQNSF---GR----------------DLNDAY-----E------- TRA1_Scer_TRRAP -STTL------L-APYIR------P----------------KFNADF-----I------- ATR_Ddis_ATR -----------N-HPKKA------------------------------------------ DNAPK_Ddis_DNAPK -SGDY------N-LKFAKEH---EA--------------------SY-----L------- SMG1_Ddis_SMG1 VCKTP------HEKWFTKCH---FE----------------TINKTI-----R------- Tor_Ddis_FRAP -PETT------SETSFLQAF---GR----------------DLQEAL-----E------- TRRAP_Ddis_TRRAP EIKYQ------NSKEFLEAY---KS----------------EFKVDF-----IEFNLDDI ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR -----------N-RQVDS------------------------------------------ DNAPK_Spur_DNAPK -QTVE------P-GPYWKKF---GR----------------EWQKRF-----D------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -QATA------Q-DPIFQKL---KN----------------QFKIDF-----D------- CC1G_00839_Ccin_ATM -E--------------------------------SRQRIEAMK----------------- CC1G_08126_Ccin_ATR -----------E-YPVSKEH---SL----------------S------------------ CC1G_00894_Ccin_FRAP -PTTA------RETSFAQVF---GR----------------ELAEAR-----E------- CC1G_06302_Ccin_PI3K GGSER------RELM--RRQGLLVD----------------TLAKRA-----R------- CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -T-----------ALVVDSL---SG----------------EARSFY-----D------- CC1G_00331_Ccin_TRRAP -----------Q-DAIQKDY---EE----------------DFI---------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK -KGAR------Q-KTFAQAY---AK----------------NIED--------------- AqueK046_Aque_FRAP -PETL------KEISFNH------------------------------------------ AqueK047_Aque_SMG1 PPETQ------NERQFQAEY---GE----------------LITMAI-----Q------- AqueK048_Aque_TRRAP -QAAA------Q-DPAFQRL---KN----------------QFDTDF-----D------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -----------F-APGAS------------------------------------------ DNAPK_Smoe_DNAPK -AGEY------N-VKFARDY---SK--------------------PV-----V------- FRAP_Smoe_FRAP GAVTL------KEIAF--AY---GR----------------ELQEAH-----E------- SMG1_Smoe_SMG1 PAETP------HEVWFQEHF---GG----------------QLRAAI-----T------- GK008_Glam_FRAP -PETQ------SESVFIQMF---SS----------------QLQAAW-----D------- GK009_Glam_PIKK-Unclassified NPAYT------RYIIFSTTM---TN----------------V----LKYMQLE------- TRRAP_Hsap_TRRAP -------------F-SVPGSMKLHNLISKLKKWIK----I------------LEAKTKQL SMG1_Hsap_SMG1 -----------KLK-TPLN---PAKPGSSWIPFKE----I------------MLSLQQRA FRAP_Hsap_FRAP -----------WCR-KYMKSGNVKDLTQAWDLYYH----V------------FRRISKQL mei-41_Dmel_ATR -----------------DRT-------YKLSD----LDTR------------LSKLCKQP CG2905_Dmel_TRRAP -------------F-SKPGAMKLHNLISKLKTWIK----V------------LETKVKKL CG6535_Dmel_ATM ------------R----------------------------------------------- CG4549_Dmel_SMG1 -----------ALR-HRRY-------PEAWDKLKQ----L------------YHILQSNM FRAP_Mmus_FRAP -----------WCR-KYMKSGNVKDLTQAWDLYYH----V------------FRRISKQL DNAPK_Mmus_DNAPK ------------SF-GNGGSK---LLTMKVDDFCKITGSL------------LVRMKKDS ATR_Mmus_ATR ----------------SNST-------LSMST----HFKM------------LKRLVEDP ATM_Mmus_ATM ------------R----------------------------------------------- C47D12.1_Cele_TRRAP -----------I---HAVDAPRPQGYIRIVLDWIR----A------------IRRRFDRL B0261.2_Cele_FRAP -----------YVQ-AFESSGNVKDLNQAWEIYCS----V------------FKKLRDQL atm-1_Cele_ATM -------------------------------HDLK----I----------------FKCK atl-1_Cele_ATR -------------------DCKLSEKVDGLKTMFR----D------------KKYDPKEL TEL1_Scer_ATM ----------------NTKT-------LRLAN-----LKI------------GQYWLKQL MEC1_Scer_ATR ------------------KLR---------NIVYS----I------------LDTLIKEK ATM_Hsap_ATM ------------K----------------------------------------------- ATR_Hsap_ATR ----------------SSST-------LSMST----HFKM------------LKKLVEEA DNAPK_Hsap_DNAPK ------------HF-GKGGSK---LLRMKLSDFNDITNML------------LLKMNKDS TOR_Dmel_FRAP -----------WSQ-RYKTSAVVMDLDRAWDIYYH----V------------FQKISRQL SMG1_Mmus_SMG1 -----------KLK-TPSN---PAKPGSSWIPFKE----I------------MLSLQQRA TRRAP_Mmus_TRRAP -------------F-SVPGSMKLHNLISKLKKWIK----I------------LEAKTKQL smg-1_Cele_SMG1 -----------ESR-ISR----TTSPEKSWIPFKN----L------------IANFVHRN TOR1_Scer_FRAP -----------WLN-NYKKSKDINNLNQAWDIYYN----V------------FRKITRQI TOR2_Scer_FRAP -----------WLM-NYKKSKDVSNLNQAWDIYYN----V------------FRKIGKQL TRA1_Scer_TRRAP -------------D-NKP---DYETYIKRLRYWRR----R------------LENKLDRA ATR_Ddis_ATR -----------------NKR-------YSIKM-----SEI------------FKKLYEMK DNAPK_Ddis_DNAPK -----------SNF-GKDSTK---LARMDQKKFLEIFAEM------------SGNMNKNM SMG1_Ddis_SMG1 -----------AFE-KQNK------PTSPFDVLHD----L------------I----AEF Tor_Ddis_FRAP -----------WSK-KYEKTRKEGDLNQAWDLYYQ----V------------FRRIYKQL TRRAP_Ddis_TRRAP VSDTIKKESDQETNVVEG----TTNVSKELETTSE----K------------QQQQQQQ- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ----------------GCQR-------LSINS----DFRS------------LKRLLADS DNAPK_Spur_DNAPK -----------SSF-GQDGSK---LAAMDYKTWSKLRQDI------------CAKMTPGK FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------------F-SQPGATKLRNLIAMLKKWIK----I------------IETRTKLL CC1G_00839_Ccin_ATM -------------------------------LACK----A----------------YRAW CC1G_08126_Ccin_ATR -------------------------------------------------------MPKLF CC1G_00894_Ccin_FRAP -----------ACK-RYQIYGDPTELDKAWDIYYG----V------------FKKVEKQL CC1G_06302_Ccin_PI3K -----------ELR-ISK---DP--RPKKIEKLRA----L-------------------- CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K -------------R-EFTFFNEVTSISGKLKPFIK----KTKPEKKAKIDEEMAKIVVDA CC1G_00331_Ccin_TRRAP -----------TS---KPDYS---QYMQRLRQWRD----R------------FEKTLDAR AqueK043_Aque_ATM ------------K----------------------------------------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------KF-GKGGAK---IISMSGTQLASAFNEV------------YNKMRESL AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 -----------KLQ-NPSN---YKSSINVWDPFKQ----L------------QQMLMHRA AqueK048_Aque_TRRAP -------------F-SSPGPKRLSVLITKLKRWIK----I------------LELKTKSL ATM_Smoe_ATM ------------D----------------------------------------------- ATR_Smoe_ATR -----------------EKA-------RSLTL----STSD------------FSSLKRMM DNAPK_Smoe_DNAPK -----------KAL-GEDGSK---LLQMDEKKFATAIAGV------------LTSLQKAI FRAP_Smoe_FRAP -----------WCM-EYRRTGNEAELTQAWDLYYH----V------------FKRINKQL SMG1_Smoe_SMG1 -----------TFK-TPPG--GNITLNDVWKPFDA----I------------AASLSNH- GK008_Glam_FRAP -----------SCR-QFPVTNDLVCLNIVMKHYKE----I------------YDRIHSEL GK009_Glam_PIKK-Unclassified -----------YAK-KSLNTSK-------ECLLP----HI------------ISGSFFLI TRRAP_Hsap_TRRAP P--K---------------------------------------F----------FLIEEK SMG1_Hsap_SMG1 QKRAS-------------------------------------YI----------LRLEEI FRAP_Hsap_FRAP --PQL-------------------------------------TS----------LELQYV mei-41_Dmel_ATR ---EF-------------------------------------S----------------- CG2905_Dmel_TRRAP P--T---------------------------------------S----------FLIEDK CG6535_Dmel_ATM --PVS-------------------------------------DS----------VRNKQF CG4549_Dmel_SMG1 IRGSG-------------------------------------ST----------LKMQSI FRAP_Mmus_FRAP --PQL-------------------------------------TS----------LELQYV DNAPK_Mmus_DNAPK ----K-------------------------------------LP----------GNLKEY ATR_Mmus_ATR ---TF-------------------------------------S----------------- ATM_Mmus_ATM --AQR-------------------------------------KG----------INIPAN C47D12.1_Cele_TRRAP P--R---------------------------------------R----------IPLESS B0261.2_Cele_FRAP --ATL-------------------------------------NS----------LDLVYV atm-1_Cele_ATM L--R---------------------------------------Q----------LPIPTI atl-1_Cele_ATR V--M---------------------------------------N----------RRVDCD TEL1_Scer_ATM ---NM-------------------------------------E----------------- MEC1_Scer_ATR S--DL--------------------------------------I------------LK-L ATM_Hsap_ATM --TQR-------------------------------------KG----------INIPAD ATR_Hsap_ATR ---TF-------------------------------------S----------------- DNAPK_Hsap_DNAPK ----K-------------------------------------PP----------GNLKEC TOR_Dmel_FRAP --PQL-------------------------------------TS----------LELPYV SMG1_Mmus_SMG1 QKRAS-------------------------------------YI----------LRLDEI TRRAP_Mmus_TRRAP P--K---------------------------------------F----------FLIEEK smg-1_Cele_SMG1 SKKGM-------------------------------------QT----------FETEDI TOR1_Scer_FRAP --PQL-------------------------------------QT----------LDLQHV TOR2_Scer_FRAP --PQL-------------------------------------QT----------LELQHV TRA1_Scer_TRRAP S--K---------------------------------------K----------ENLEVL ATR_Ddis_ATR ---DL------------------------------------------------------- DNAPK_Ddis_DNAPK KPNST-------------------------------------AS----------MKLKDF SMG1_Ddis_SMG1 QQYRL-------------------------------------IS----------LSLSSV Tor_Ddis_FRAP --PQM-------------------------------------SS----------LELQYV TRRAP_Ddis_TRRAP -LPTISILLLIEKLIKWIDRKPDNSLITVVNTDQSTNYYGIDTM----------ICLESI ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ---NF-------------------------------------S----------------- DNAPK_Spur_DNAPK ----D-------------------------------------DP----------GNLKEY FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP P--K---------------------------------------S----------FLIEER CC1G_00839_Ccin_ATM A--R---------------------------------------Q-----------PL--- CC1G_08126_Ccin_ATR P--RL-------------------------------------KA------------IGEC CC1G_00894_Ccin_FRAP --PSL-------------------------------------TT----------LDLQYV CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ---------------------------------------------------------KS- CC1G_13883_Ccin_PI4K --PFM-------------------------------------A----------------- CC1G_00331_Ccin_TRRAP P--QH-------------------------------------QP------------LALL AqueK043_Aque_ATM --TEK-------------------------------------KP----------IRIPPN AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK NKF-S-------------------------------------SS----------ALLKDY AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 QKRMQ-------------------------------------TP----------LSLNEI AqueK048_Aque_TRRAP Q--K---------------------------------------S----------FLLEDR ATM_Smoe_ATM --CLK--------------------------------------------------PVPYP ATR_Smoe_ATR ---PL------------------------------------------------------- DNAPK_Smoe_DNAPK KDLPG-------------------------------------GK----------LSLASF FRAP_Smoe_FRAP --PSV-------------------------------------TT----------LELQYV SMG1_Smoe_SMG1 HK--R-------------------------------------SA----------VVLQDV GK008_Glam_FRAP --PFL-------------------------------------NT----------IDLLQT GK009_Glam_PIKK-Unclassified --PTL-------------------------------------EAISSLREFEYSMTTDKR TRRAP_Hsap_TRRAP CRFLS----------NFSA-------QT-AEVEIPG------------EF---------- SMG1_Hsap_SMG1 SPWLA-------------------AMTN-TEIALPG------------E----------- FRAP_Hsap_FRAP SPKLL-------------------MCRD-LELAVPG------------TY---------- mei-41_Dmel_ATR QILLP----------FEK---------Y-MQPTLPLN---------SDSN---------- CG2905_Dmel_TRRAP CRFLS----------NFSQ-------KT-AEVELPG------------EL---------- CG6535_Dmel_ATM DKVR--------------------RWRNLNAVHCPT------------LE---------- CG4549_Dmel_SMG1 SPVLC-------------------GIGR-MRISMPG------------LD---------- FRAP_Mmus_FRAP SPKLL-------------------MCRD-LELAVPG------------TY---------- DNAPK_Mmus_DNAPK SPWMS----------EFKA-----QFLK-NELEIPG------------QY---------- ATR_Mmus_ATR EILIP----------LQS---------V-MIPTLPSV---------LGA----------- ATM_Mmus_ATM QPIT--------------------KLKNLEDVVVPT------------ME---------- C47D12.1_Cele_TRRAP SPYLA----------RFSH-------RT-GCIEMPY------------DL---------- B0261.2_Cele_FRAP SPNLV-------------------SAKD-LELVVPG------------TY---------- atm-1_Cele_ATM ------------------S-------Q---KIGCP------------------------- atl-1_Cele_ATR CKILSGIMVPVRSVIDESV-------HD-TEIRDDG------------FE---------- TEL1_Scer_ATM KL------------------------------PLPTS-----------NF---------- MEC1_Scer_ATR KPY--------------------------TTLALVG------------KP---------- ATM_Hsap_ATM QPIT--------------------KLKNLEDVVVPT------------ME---------- ATR_Hsap_ATR EILIP----------LQS---------V-MIPTLPSI---------LGTH---------- DNAPK_Hsap_DNAPK SPWMS----------DFKV-----EFLR-NELEIPG------------QY---------- TOR_Dmel_FRAP SPKLM-------------------TCKD-LELAVPG------------SY---------- SMG1_Mmus_SMG1 SPWLA-------------------AMTN-TEIALPG------------E----------- TRRAP_Mmus_TRRAP CRFLS----------NFSA-------QT-AEVEIPG------------EF---------- smg-1_Cele_SMG1 SPYLA-------------------SLSN-SCVPMPG------------QE---------- TOR1_Scer_FRAP SPQLL-------------------ATHD-LELAVPG------------TY---------- TOR2_Scer_FRAP SPKLL-------------------SAHD-LELAVPG------------TR---------- TRA1_Scer_TRRAP CPHLS----------NFHH------QKF-EDIEIPG------------QY---------- ATR_Ddis_ATR TVILP----------LQS---------S-LNVSLPPN---------GK------------ DNAPK_Ddis_DNAPK SGWLA----------DFDRSN---YQTS-HQMEIPG------------QY---------- SMG1_Ddis_SMG1 NPSLA-------------------LFRP-TITQMPG------------TDLNYFNINHIH Tor_Ddis_FRAP SPKLL-------------------NSNN-MELAVPG------------TY---------- TRRAP_Ddis_TRRAP CPQLV-------------------NFKP-SILEIPG------------QY---------- ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR KIIVP----------LQS---------A-MTVTLPSS---------QS------------ DNAPK_Spur_DNAPK SPWFT----------AFQT------LRG-DELEIPG------------QY---------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP CRFLS----------HFSS-------AT-ADVELPG------------EF---------- CC1G_00839_Ccin_ATM -PKDK----------MRVG-------V---QLAIPPSQPILGLPRMDGLV---------- CC1G_08126_Ccin_ATR SLLIP----------LLV---------S-LTVSLPS------------SS---------- CC1G_00894_Ccin_FRAP SPSLL-------------------KARH-LDLAVPG------------TY---------- CC1G_06302_Ccin_PI3K ---IS-------------------DSKN-NLASMPP------------L----------- CC1G_04234_Ccin_PI4K ------------------------------------------------RI---------- CC1G_13883_Ccin_PI4K ------------------------TFK--------------------------------- CC1G_00331_Ccin_TRRAP SHYLT----------EFQY------SKV-DEIEVPG------------QY---------- AqueK043_Aque_ATM CPLL--------------------KLKK-NKVPIPT------------LD---------- AqueK044_Aque_ATR --------------------------------TLPAC------------Q---------- AqueK045_Aque_DNAPK SPWLD----------TFRQ-----EDYL-QVIEVPG------------LY---------- AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 SPHLA-------------------AIQS-SCISMPG------------H----------- AqueK048_Aque_TRRAP CRFLS----------NFSL-------NT-ADVEMPG------------EH---------- ATM_Smoe_ATM RDIR--------------------SVRRLNLVPVLT------------AN---------- ATR_Smoe_ATR QVIMP----------VQR---------A-LAVTLPAD---------GL------------ DNAPK_Smoe_DNAPK SKWMA----------NFDQPRGRGSSSD-DLIEIPG------------QY---------- FRAP_Smoe_FRAP SPALL-------------------NARN-LELAVPG------------TY---------- SMG1_Smoe_SMG1 SPRLA-------------------ALTH-SDAPMPG------------L----------- GK008_Glam_FRAP SPLLY-------------------NISN-TNLCVPG------------SY---------- GK009_Glam_PIKK-Unclassified SPHQI-------------------DNHT-ECVSVLE------------HY---------- TRRAP_Hsap_TRRAP --------------------LM-----------P-K----------PTHYYIKIA---R- SMG1_Hsap_SMG1 -----------------------------------VSA----------RDTVTIH---S- FRAP_Hsap_FRAP --------------------DP---------------N----------QPIIRIQ---S- mei-41_Dmel_ATR --------------------SS---------EGSHLPANQSTVNWFP-YQQIYIS---G- CG2905_Dmel_TRRAP --------------------LI-----------P-L----------SSHYYVRIA---R- CG6535_Dmel_ATM --------------------LPV--------MPSK------------EYSIISVV---K- CG4549_Dmel_SMG1 --------------------AH-------------GPD----------GDQVYIE---S- FRAP_Mmus_FRAP --------------------DP---------------N----------QPIIRIQ---S- DNAPK_Mmus_DNAPK --------------------DG-----------KSKP--------LP-EYHVRIS---G- ATR_Mmus_ATR -------------------------------HANHDP--------FP-GHWAYLA---G- ATM_Mmus_ATM --------------------IKV--------DPTG-E----------YENLVTIK---S- C47D12.1_Cele_TRRAP --------------------LNVLRAKNHTLMASNQ-T---------GQYISMLS---R- B0261.2_Cele_FRAP --------------------DP---------------S----------APIVSIQ---S- atm-1_Cele_ATM --------------------------------GDYS-T----------TDLITWK---R- atl-1_Cele_ATR --------------------ES-----------C-H---------LP--DRYLIH---D- TEL1_Scer_ATM --------------------TV---------KSSADG---------R-KARPYIV---S- MEC1_Scer_ATR --------------------EL-------------GI---------L-APVVSII---R- ATM_Hsap_ATM --------------------IKV--------DHTG-E----------YGNLVTIQ---S- ATR_Hsap_ATR --------------------AN---------HASHEP--------FP-GHWAYIA---G- DNAPK_Hsap_DNAPK --------------------DG-----------RGKP--------LP-EYHVRIA---G- TOR_Dmel_FRAP --------------------NP---------------G----------QELIRIS---I- SMG1_Mmus_SMG1 -----------------------------------VSA----------RDTVTIH---S- TRRAP_Mmus_TRRAP --------------------LM-----------P-K----------PTHYYIKIA---R- smg-1_Cele_SMG1 --------------------S--------------VEF----------DRVVSIS---R- TOR1_Scer_FRAP --------------------FP---------------G----------KPTIRIA---K- TOR2_Scer_FRAP --------------------AS-------------G-G----------KPIVKIS---K- TRA1_Scer_TRRAP --------------------LL-----------N-K---------DNNVHFIKIA---R- ATR_Ddis_ATR ---------------------P---------DKSY-P---------AFGSLPLIG---S- DNAPK_Ddis_DNAPK --------------------DG-----------IGKP--------QP-ETHVTIS---S- SMG1_Ddis_SMG1 HHHHHHNHHGNNNNQHSTSSGN-------------LPI----------QNQVTIQ---L- Tor_Ddis_FRAP --------------------KA---------------S----------ENVIRIQ---S- TRRAP_Ddis_TRRAP --------------------N--------------TNR-----DPNI-ENNVKVEKVGM- ATMa_Spur_ATM ------------------------------------------------EAYIKMA---Y- ATR_Spur_ATR ---------------------V---------HHTHDP--------FP-LTEVYII---G- DNAPK_Spur_DNAPK --------------------DG-----------SKKP--------LP-AYHVKIA---G- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP --------------------LT-----------P-K----------HSHYTIRIA---R- CC1G_00839_Ccin_ATM --------------------PVLTA--DTPIDPTLK-----------YENCVWIH---K- CC1G_08126_Ccin_ATR --------------------SA---------AGTHQP--------FP-DDAPTFK---E- CC1G_00894_Ccin_FRAP --------------------QS---------------G----------RPVITIA---S- CC1G_06302_Ccin_PI3K ---------------------P-------------LPL----------NAKIEVT---GI CC1G_04234_Ccin_PI4K --------------------R--------------QS------SP-Y----GHLASLA-- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP --------------------TE-----------DKDS---------N-QSFVRIQ---K- AqueK043_Aque_ATM --------------------HPI--------DPSG-R--------Y-KDSMVTIT---S- AqueK044_Aque_ATR --------------------DA---------PSDHNP--------FP-GVQPSIV---S- AqueK045_Aque_DNAPK --------------------DG-----------RSKP--------LP-EYHAKIT---R- AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 -----------------------------------SQM----------DEPVLLE---S- AqueK048_Aque_TRRAP --------------------LE-----------L-Q----------TMPYYVKIA---R- ATM_Smoe_ATM --------------------IPV--------DRNC-D--------YSGKNLPYFD---G- ATR_Smoe_ATR ---------------------S---------NSSYNP--------FPSGDCSTIF---A- DNAPK_Smoe_DNAPK --------------------DG-----------LQCP--------DV-SSHITLV---G- FRAP_Smoe_FRAP --------------------RP-------------GPE----------ANVVTIQ---S- SMG1_Smoe_SMG1 ---------------------E-------------FPD----------ADLVTVA---N- GK008_Glam_FRAP --------------------HP---------------A----------RAITTIV---K- GK009_Glam_PIKK-Unclassified --------------------Y---------------EY----------YSSRYAA---S- TRRAP_Hsap_TRRAP FMPRVEIV-QKHNTAARRLYIR-GHNG--------KIYPYLVM--NDACLTE-------- SMG1_Hsap_SMG1 VGGTITIL-PTK-TKPKKLLFL-GSDG--------KSYPYLFK--G---LED-------- FRAP_Hsap_FRAP IAPSLQVI-TSK-QRPRKLTLM-GSNG--------HEFVFLLK--G---HED-------- mei-41_Dmel_ATR FQESVLIL-RSA-AKPKKLTIR-CSDG--------KDYDVLVK--P---KDD-------- CG2905_Dmel_TRRAP FMPRVEIV-QKNNTAARRLYIR-GTNG--------KIYPYLVV--LDSGLGD-------- CG6535_Dmel_ATM WTNETTQC-GGL-NAPVKIMCV-CSDG--------KIRAQLVK--G---KDD-------- CG4549_Dmel_SMG1 VESSVCVL-PTK-TKPKKVAFY-GSNG--------QRYTFLFK--G---MED-------- FRAP_Mmus_FRAP IAPSLQVI-TSK-QRPRKLTLM-GSNG--------HEFVFLLK--G---HED-------- DNAPK_Mmus_DNAPK FDERVKVM-LSL-RKPKRIVIR-GHDE--------KEYPFLVK--G---GED-------- ATR_Mmus_ATR FDDVVEIL-SSL-QKPKKISLK-GSDG--------KFYIMMCK--P---KDD-------- ATM_Mmus_ATM FKTEFRLA-GGL-NLPKIIDCV-GSDG--------KERRQLVK--G---RDD-------- C47D12.1_Cele_TRRAP FEPNFEIVIKGG-QVIRKIYIR-GQTG--------KSAAFYLK--K---SVQ-------- B0261.2_Cele_FRAP FSSKMNVI-TSK-QRPRKMVIR-GSNG--------LDYQFLLK--G---HED-------- atm-1_Cele_ATM WKDVFTI-ADGI-STPKIWEIE-GSDG--------KWYKTVWK------KDD-------- atl-1_Cele_ATR FSDKVKVL-HS-NTKPVIIKLT-TKTG--------RIVRLICK--KD---DD-------- TEL1_Scer_ATM VNETVGITTTGL-SLPKIVTFN-ISDG--------TTQKALMK--GS--NDD-------- MEC1_Scer_ATR FGSSYKVF-SSL-KKPKQLNII-GSDG--------NIYGIMCK------KED-------- ATM_Hsap_ATM FKAEFRLA-GGV-NLPKIIDCV-GSDG--------KERRQLVK--G---RDD-------- ATR_Hsap_ATR FDDMVEIL-ASL-QKPKKISLK-GSDG--------KFYIMMCK--P---KDD-------- DNAPK_Hsap_DNAPK FDERVTVM-ASL-RRPKRIIIR-GHDE--------REHPFLVK--G---GED-------- TOR_Dmel_FRAP IKTNLQVI-TSK-QRPRKLCIR-GSNG--------KDYMYLLK--G---HED-------- SMG1_Mmus_SMG1 VGGTITIL-PTK-TKPKKLLFL-GSDG--------KSYPYLFK--G---LED-------- TRRAP_Mmus_TRRAP FMPRVEIV-QKHNTAARRLHIR-GHNG--------KIYPYLVM--NDACLTE-------- smg-1_Cele_SMG1 VARQVTIL-PTK-TRPKKLGFV-GSDG--------KQVAFLFK--G---RED-------- TOR1_Scer_FRAP FEPLFSVI-SSK-QRPRKFSIK-GSDG--------KDYKYVLK--G---HED-------- TOR2_Scer_FRAP FEPVFSVI-SSK-QRPRKFCIK-GSDG--------KDYKYVLK--G---HED-------- TRA1_Scer_TRRAP FLPTVDFV-RGTHSSYRRLMIR-GHDG--------SVHSFAVQ--Y-PAVRH-------- ATR_Ddis_ATR FEDQIDIM-PSL-QGPKKINVN-DRQG--------NRYSFLLK--P---NDD-------- DNAPK_Ddis_DNAPK FDTNVLVM-GSL-RKPKRVKIH-GNDE--------LDYPFLIK--G---GED-------- SMG1_Ddis_SMG1 IKPTIYLL-PTK-TKPKKMAML-GSDG--------NLYYYLLK--G---RED-------- Tor_Ddis_FRAP FSQALSVI-PSK-QRPRKLTII-GSDG--------LEYTFLLK--G---HED-------- TRRAP_Ddis_TRRAP FAKLIKHS-NGM-V-CPRITLY-GGNG--------KAYQFLIE--S---SPSLINGITNS ATMa_Spur_ATM WD---------------------------------MSSKKSET--G---KDD-------- ATR_Spur_ATR FDDTVEVL-PSL-QRPKKIGIQ-GSDG--------RLYVMMCK--P---KDD-------- DNAPK_Spur_DNAPK FDETVLTL-SSL-RKPKCITIR-GNDE--------MDYPFLVK--V---GED-------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP FMPHVEIT-HKHNTAARRLYIR-GSNG--------KIYPYLVV--NDASMAE-------- CC1G_00839_Ccin_ATM YENVFET-AGGV-NCPKISWCY-GTDG--------VRYKQLFK--G---NDD-------- CC1G_08126_Ccin_ATR FSDEIDVM-RSM-ARPRKIWIT-GSDG--------GEYIMLIK--P---KDD-------- CC1G_00894_Ccin_FRAP FATKLTVI-ASK-QRPRRLSLK-GSDG--------RDYQYVLK--G---HED-------- CC1G_06302_Ccin_PI3K IPEKSSVF-KSN-LYPLLLYFQ-CSDG--------SEYPVIFK--D---GDD-------- CC1G_04234_Ccin_PI4K -------------------------QW--------DCMSVIVK--T---GGD-------- CC1G_13883_Ccin_PI4K --VRKERV-VVN-SDPDS-LLD-GDGGIETMEEYDVWQQAIFK--V---GDD-------- CC1G_00331_Ccin_TRRAP FAPKFETV-RSNGAYWKRFTLI-GNDH--------SKTSFIVQLPC---HRQ-------- AqueK043_Aque_ATM FDAHFSLC-GGV-NLPKVLSAL-CSDG--------KRRRQLIK--G---RDD-------- AqueK044_Aque_ATR FDDRVDIL-NSL-QRPKKVIIL-ASDG--------NRYTMMCK--P---KDD-------- AqueK045_Aque_DNAPK FDAKVLIL-SSL-RKPKRLTII-GDDT--------REYMFLVK--G---GED-------- AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 FCLDVSVL-PTK-TKPKKISMI-GSDG--------RRHTYLFK--G---LED-------- AqueK048_Aque_TRRAP FMPRVEIV-QKHNTTVRRLYIQ-GDNG--------KIYPYLVL--NDVQASK-------- ATM_Smoe_ATM FEGSITVM-RGV-NVPKVVLCR-GSDG--------QKYRQLAK-SG---GDD-------- ATR_Smoe_ATR IRDDVEIL-VSL-QRPKKVVLV-ASDG--------TEHPFLCK--P---KDD-------- DNAPK_Smoe_DNAPK FDETLISL-SSK-QRPKILTMR-GSDE--------KEYKFIVK--G---GED-------- FRAP_Smoe_FRAP FDPQLIVM-PSK-QRPRKCTIK-GSDG--------QDYTFLLK--G---HED-------- SMG1_Smoe_SMG1 FNDQITIL-ATK-TKPKKVSVT-GSDG--------QVYNYLLK--G---RED-------- GK008_Glam_FRAP FYQKVFVI-RSK-QRPRKVGLV-ASDG--------EYYAFLLK--G---HED-------- GK009_Glam_PIKK-Unclassified YVTMVRH-FSSK-RAPLLFRMSRTKND--------HGTRLILK--C---GED-------- TRRAP_Hsap_TRRAP -----SRREERVLQLLRLLNPCLEKRKETT-KRHL---FFTVPR-VVAVSPQMRLVEDNP SMG1_Hsap_SMG1 -----LHLDERIMQFLSIVNTMFATINRQE-TPRF---HARHYS-VTPLGTRSGLIQWVD FRAP_Hsap_FRAP -----LRQDERVMQLFGLVNTLLANDPTSL-RKNL---SIQRYA-VIPLSTNSGLIGWVP mei-41_Dmel_ATR -----LRRDARLMEFNGLVKRYLHQDAPAR-QRRL---HIRTYA-VLPFNEECGLVEWLP CG2905_Dmel_TRRAP -----ARREERVLQLKRMLNYYLEKQKETS-RRFL---NITVPR-VVPISPQMRLAEDNP CG6535_Dmel_ATM -----LRQDAVMQQVFGIVNELLNQDSEFI-ERKL---KLRTYK-VTPLSMRSGILEWCT CG4549_Dmel_SMG1 -----LHLDERIMQFLSISNAIMACRSDAPGNGCY---RAHHYS-VIPLGPQSGLISWVD FRAP_Mmus_FRAP -----LRQDERVMQLFGLVNTLLANDPTSL-RKNL---SIQRYA-VIPLSTNSGLIGWVP DNAPK_Mmus_DNAPK -----LRQDQRIEQIFEVMNAILSQDAACS-QRNM---QLRTYR-VVPMTSRLGLIEWIE ATR_Mmus_ATR -----LRKDCRLMEFNSLINKSLRKDAESR-RREL---HIRTYA-VIPLNDECGIIEWVN ATM_Mmus_ATM -----LRQDAVMQQVFQMCNTLLQRNTETR-KRKL---TICTYK-VVPLSQRSGVLEWCT C47D12.1_Cele_TRRAP -----DEPTNRVPQMFKHLDHVLQTDRESA-RRHL---HAPTVL-QMRVGQKTTLYEVAS B0261.2_Cele_FRAP -----PRQDERVMQLFGLVNTLLANNSETC-RRNL---TIQRYS-IVALSKDSGLIGWVP atm-1_Cele_ATM -----VRQDVLVEQMFDVTNNMLEK---------A---MLRTYN-VVPLDTECGVIEFCG atl-1_Cele_ATR -----LSKDYHFTKMVEMCNDLLMKDEQTR-IQKM---TATTYS-VIPLGKQGGIIEFME TEL1_Scer_ATM -----LRQDAIMEQVFQQVNKVLQNDKVLR-NLDL---GIRTYK-VVPLGPKAGIIEFVA MEC1_Scer_ATR -----VRQDNQYMQFATTMDFLLSKDIASR-KRSL---GINIYS-VLSLREDCGILEMVP ATM_Hsap_ATM -----LRQDAVMQQVFQMCNTLLQRNTETR-KRKL---TICTYK-VVPLSQRSGVLEWCT ATR_Hsap_ATR -----LRKDCRLMEFNSLINKCLRKDAESR-RREL---HIRTYA-VIPLNDECGIIEWVN DNAPK_Hsap_DNAPK -----LRQDQRVEQLFQVMNGILAQDSACS-QRAL---QLRTYS-VVPMTSRLGLIEWLE TOR_Dmel_FRAP -----LRQDERVMQLFSLVNTLLLDDPDTF-RRNL---AIQRYA-VIPLSTNSGLIGWVP SMG1_Mmus_SMG1 -----LHLDERIMQFLSIVNTMFATINRQE-TPRF---HARHYS-VTPLGTRSGLIQWVD TRRAP_Mmus_TRRAP -----SRREERVLQLLRLLNPCLEKRKETT-KRHL---FFTVPR-VVAVSPQMRLVEDNP smg-1_Cele_SMG1 -----LHLDERVMQFLRLCNVMLQPGKGKH-RQSVAAYQAHHYA-VIPLGPRSGLIKWVE TOR1_Scer_FRAP -----IRQDSLVMQLFGLVNTLLKNDSECF-KRHL---DIQQYP-AIPLSPKSGLLGWVP TOR2_Scer_FRAP -----IRQDSLVMQLFGLVNTLLQNDAECF-RRHL---DIQQYP-AIPLSPKSGLLGWVP TRA1_Scer_TRRAP -----SRREERMFQLYRLFNKSLSKNVETR-RRSI---QFNLPI-AIPLSPQVRIMNDSV ATR_Ddis_ATR -----LRKDQRVMEFNTMVNKLIKKDPACR-KRNL---KIRTYT-VIPFNEESGIIEWVS DNAPK_Ddis_DNAPK -----LRLDQRIQQLFGIMNEILKRDTACN-KRSL---NVTTYQ-VVPMTSKVGIIEWLN SMG1_Ddis_SMG1 -----LHLDERIMQLLNVVDQLLMNDKKPT-LKLL---RTRNYS-VIPLSQSSGLIQWVE Tor_Ddis_FRAP -----LRQDERVMQLFSLVNNLLSANHETA-KSHL---SIRRFS-VIPLSPNSGLIGWVP TRRAP_Ddis_TRRAP NNNNVARVYERKNQLLGSINSMLIKNRETR-RRGL---TLNSYPTVVPIKNSLTMIQNIG ATMa_Spur_ATM -----LRQDAVMQQVFGLVNQLLSKSTETK-RRKL---QIRRYK-VVPLCQNTGLLEWCE ATR_Spur_ATR -----LRKDNRLMEFNGIINKCLRKNVESR-RREL---YIRTYT-VIPLNEECGLIEWVS DNAPK_Spur_DNAPK -----LRMDQRIEQLFCIMNSILAQDAACS-QRGL---TLTTYQ-VVPMTPRLGILEWVK FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -----SRREERVLQVLRMLNHYLGKRKETA-KRQL---QFTVPR-VVAVSPQMRLVEDSP CC1G_00839_Ccin_ATM -----MRQDAVMEQVFELVNRILVKDRETS-RRSL---RVRSYK-VVPLGKQAGVLEFVS CC1G_08126_Ccin_ATR -----LRKDARLMDFDTIINRLLKANADAR-RRKL---YIRTYA-VVPLNEECGCIEWVQ CC1G_00894_Ccin_FRAP -----LRQDERVMQLFSLVNTLLSVDTNSF-KRRL---HIQRYP-VIPLAPNAGLLGWVQ CC1G_06302_Ccin_PI3K -----MRQDQLVIQLFTLMDQLLRKEN-----LDL---KLSPYD-VLATGPLQGMVQFIP CC1G_04234_Ccin_PI4K -----LRQEQLAVQLIREFQSIWAEEK-----CAC---WVKHFR-ILITGSTSGLIETIK CC1G_13883_Ccin_PI4K -----CRQDVLALQVIAMFKNIFE----SI-GLTL---YLFPYR-VTATAPGCGVIDVVP CC1G_00331_Ccin_TRRAP -----WRREERVIQLLRTLNCTLVRKKESR-RRNL---AFHLPA-VVSLSPAVRLFQTDS AqueK043_Aque_ATM -----LRQDAVMQQVFGLVNQLLCKKPSTA-NRKL---LIRTYK-VVPLSQCSGIVQWCE AqueK044_Aque_ATR -----LRKDCRLMEFNTVINK----------------------A-VIPLSEDSGLVEWVD AqueK045_Aque_DNAPK -----LRLDQRIEQLFETMNKVLSDDPICS-QRRL---NLRTYS-VIPVTPRVGLIEWVR AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 -----LHLDERIMQFMAIVNNMFAKAHKHQ-TQLY---LARDYA-VIPLGARSGLIQWVD AqueK048_Aque_TRRAP -----NRREERVLQLFRLLNYSLKKEKETC-KRHL---QFSVPK-VVALSPQMRLLEDDV ATM_Smoe_ATM -----LRQDAVMEQLFGLVNTLLKDHSETR-IRCL---QIRTYK-VVPFTPSAGALEWVN ATR_Smoe_ATR -----LRKDARMMEFTGMINRLLSKDPSSR-RRKL---YIRTFA-VIPLTEDCGMVEWVS DNAPK_Smoe_DNAPK -----LRLDQRIEQLFAKMNSVLREDGACA-KREL---SMRTYA-VIPVSQQCGLLQFVD FRAP_Smoe_FRAP -----LRQDERVMQLFGLVNTLLTNARHTA-EKDL---SIQRYD-VVPLSPNSGLIGWVP SMG1_Smoe_SMG1 -----LRLDARIMQLLRASNKMLRASSATR-REGL---AVKCYS-VTPISGRAGLIQWVD GK008_Glam_FRAP -----LRQDERVMQLFTLINNLLMNDSYCS-RRGL---MVMKYP-ITPLSQNSGLLYWVP GK009_Glam_PIKK-Unclassified -----TVADYAVMQFTEELA---KCSVNTF-F---KPYFVAVLI-NIPKNQ-VSIIEHID TRRAP_Hsap_TRRAP S-----------------------SLSLVEIYKQRCAK----------------KG---- SMG1_Hsap_SMG1 G-----------------------ATPLFGLYKRWQQR----------------EA---- FRAP_Hsap_FRAP H-----------------------CDTLHALIRDYREK----------------KK---- mei-41_Dmel_ATR N-----------------------LASYRSICMNLYAQ----------------RR---- CG2905_Dmel_TRRAP N-----------------------SISLLKIFKKCCQS----------------MQ---- CG6535_Dmel_ATM N-----------------------SVPVGHYLVVEGKG-----------------G---- CG4549_Dmel_SMG1 G-----------------------VTPVFALYKKWQQR----------------RS---- FRAP_Mmus_FRAP H-----------------------CDTLHALIRDYREK----------------KK---- DNAPK_Mmus_DNAPK N-----------------------TMTLKDLLLSNMSQ----------------EE---- ATR_Mmus_ATR N-----------------------TAGLRPILTKIYKE----------------KG---- ATM_Mmus_ATM G-----------------------TVPIGEYLVNSED------------------G---- C47D12.1_Cele_TRRAP VQPYAMPPDCTRNYPASQIDIVHPYDVLTATFNGSYYP----------------DDMVLH B0261.2_Cele_FRAP N-----------------------CDTLHTLVKEYREK----------------KA---- atm-1_Cele_ATM G-----------------------TVSLKEVMCGVTRE----------------GG---- atl-1_Cele_ATR G-----------------------VTSFYETLDKLMGM----------------TS---- TEL1_Scer_ATM N-----------------------STSLHQILSKLHTN----------------DK---- MEC1_Scer_ATR N-----------------------VVTLRSILSTKYES----------------LK---- ATM_Hsap_ATM G-----------------------TVPIGEFLVNNED------------------G---- ATR_Hsap_ATR N-----------------------TAGLRPILTKLYKE----------------KG---- DNAPK_Hsap_DNAPK N-----------------------TVTLKDLLLNTMSQ----------------EE---- TOR_Dmel_FRAP H-----------------------CDTLHTLIRDYRDK----------------KK---- SMG1_Mmus_SMG1 G-----------------------ATPLFGLYKRWQQR----------------EA---- TRRAP_Mmus_TRRAP S-----------------------SLSLVEIYKQRCAK----------------KG---- smg-1_Cele_SMG1 G-----------------------ATPMFHIYRKWQMK----------------EK---- TOR1_Scer_FRAP N-----------------------SDTFHVLIREHRDA----------------KK---- TOR2_Scer_FRAP N-----------------------SDTFHVLIREHREA----------------KK---- TRA1_Scer_TRRAP S-----------------------FTTLHEIHNEFCKK----------------KG---- ATR_Ddis_ATR N-----------------------TATLRSILGGIYET----------------MD---- DNAPK_Ddis_DNAPK D-----------------------TKPLREILEEQLAH----------------QL---- SMG1_Ddis_SMG1 G-----------------------AVPLFSIYKNWYKN----------------DQ---- Tor_Ddis_FRAP H-----------------------SDTLHTLIKDFRDS----------------NK---- TRRAP_Ddis_TRRAP N-----------------------D-SIKQLAEVWYTH---SNQSNLFKPMLKYKE---- ATMa_Spur_ATM G-----------------------TMPIGLYLIGDQKKD---------------LG---- ATR_Spur_ATR N-----------------------TAGLRPILHKIYRE----------------KG---- DNAPK_Spur_DNAPK R-----------------------TTTLKDFITRSMTE----------------AE---- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP S-----------------------SLSLLDIYKKWCSK----------------QQ---- CC1G_00839_Ccin_ATM N-----------------------TSPLRNWLEAGH------------------------ CC1G_08126_Ccin_ATR N-----------------------TSPLRPILFKYYEA----------------RR---- CC1G_00894_Ccin_FRAP D-----------------------SDTLHVLIRDYRES----------------RK---- CC1G_06302_Ccin_PI3K S-----------------------KT-IAAIVSEHGNV---------------------- CC1G_04234_Ccin_PI4K D-----------------------AVSIHSIKKAEYA-----------------KR---- CC1G_13883_Ccin_PI4K N-----------------------ATSRDEMGRAKV------------------------ CC1G_00331_Ccin_TRRAP S-----------------------YISFGDIYDLHCEE----------------KG---- AqueK043_Aque_ATM G-----------------------TVPIGMYLVGPPESPL--------------EG---- AqueK044_Aque_ATR N-----------------------TTGYRPILQTTYQE----------------KG---- AqueK045_Aque_DNAPK N-----------------------TMPLKDFIQLSDPE----------------KK---- AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 N-----------------------VTPLFGIYKRWQQR----------------EA---- AqueK048_Aque_TRRAP S-----------------------ILSLSDIFKQYCNS----------------QN---- ATM_Smoe_ATM G-----------------------TIPLGQYLLGSSKV----------------PG---- ATR_Smoe_ATR H-----------------------TRGLRHILQDLYVS----------------AG---- DNAPK_Smoe_DNAPK N-----------------------TCVLDDVIKDGVAQ----------------QL---- FRAP_Smoe_FRAP N-----------------------CDTLHHLIREYRDA----------------RK---- SMG1_Smoe_SMG1 N-----------------------VTSLYSVYKAWQLR----------------QQ---- GK008_Glam_FRAP G-----------------------CDTIISLIKEFRQL----------------KR---- GK009_Glam_PIKK-Unclassified GN----------------------VVPIDELLTPVFMG-AKT------------KA---- TRRAP_Hsap_TRRAP -I-------E-H----D--NP---ISRY-------------------------------- SMG1_Hsap_SMG1 --------AL------Q--AQKAQDSYQTPQN---------------------------- FRAP_Hsap_FRAP --------IL-L----N--IEHRIML---------------------------------- mei-41_Dmel_ATR -L-------V-M----S--TR--QLQSL-------------------------------- CG2905_Dmel_TRRAP -V-------D-Y----D--MP---IVKY-------------------------------- CG6535_Dmel_ATM -AHARYRPND-W----N--NN--KCRK--------------------------------- CG4549_Dmel_SMG1 --------QV-A-------GNAGAGAVA-------------------------------- FRAP_Mmus_FRAP --------IL-L----N--IEHRIML---------------------------------- DNAPK_Mmus_DNAPK -K-------V-A----N--NSDPK----AP------------------------------ ATR_Mmus_ATR -V-------Y-M----T--GK--ELRQC-------------------------------- ATM_Mmus_ATM -AHRRYRPND-F----S--AN--QCQKK-------------------------------- C47D12.1_Cele_TRRAP FFERFAQSSSSIGQPLPTPTN--QDGTV-------------------------------- B0261.2_Cele_FRAP -K------IP-L----S--IEHKTLQ---------------------------------- atm-1_Cele_ATM -LHREFNSEE-V----S--AS--KVSSM-------------------------------- atl-1_Cele_ATR -G-------E-W----L--EK---LKFW-------------------------------- TEL1_Scer_ATM -I-------T-F----D---Q--ARKGM-------------------------------- MEC1_Scer_ATR -I-------K-Y------------------------------------------------ ATM_Hsap_ATM -AHKRYRPND-F----S--AF--QCQKK-------------------------------- ATR_Hsap_ATR -V-------Y-M----T--GK--ELRQC-------------------------------- DNAPK_Hsap_DNAPK -K-------A-A----Y--LSDPR----AP------------------------------ TOR_Dmel_FRAP --------VP-L----N--QEHRTML---------------------------------- SMG1_Mmus_SMG1 --------AL------Q--AQKAQDSYQTPQN---------------------------- TRRAP_Mmus_TRRAP -I-------E-H----D--NP---ISRY-------------------------------- smg-1_Cele_SMG1 --------AL-K----Q--ATKK-NGETVPE----------------------------- TOR1_Scer_FRAP --------IP-L----N--IEHWVML---------------------------------- TOR2_Scer_FRAP --------IP-L----N--IEHWVML---------------------------------- TRA1_Scer_TRRAP -F-------D-P----D--DI---QDFM-------------------------------- ATR_Ddis_ATR -T-------I-G----I--DR---FNQM-------------------------------- DNAPK_Ddis_DNAPK -K-------T-P----R--SNVSI-SKL-E------------------------------ SMG1_Ddis_SMG1 --------VY-K----Q--QQQQQQQLQQQQQQQQQQQQQQPQPQQQPQQQPQQQPQQQP Tor_Ddis_FRAP --------IL-L----S--IEHRLML---------------------------------- TRRAP_Ddis_TRRAP --------ML-L----N--SNLHTELLSKKD-QDG------------------------- ATMa_Spur_ATM -AHVSYRPGD-W----K--TK--TCRGK-------------------------------- ATR_Spur_ATR -L-------Y-T----S--GS--ELKAM-------------------------------- DNAPK_Spur_DNAPK -H-------K-V----Y--TSRTA----GP------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -V-------E-T----D--PP---INRY-------------------------------- CC1G_00839_Ccin_ATM ---PIYRPGD-I----S--PK--EARSK-------------------------------- CC1G_08126_Ccin_ATR -I-------K-T------------------------------------------------ CC1G_00894_Ccin_FRAP --------VL-L----N--IEYRLML---------------------------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K --------IA-E----G------------------------------------------- CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -I-------A-K----E-----------MP------------------------------ AqueK043_Aque_ATM -AHVRYRPKD-W----K--NN--ECRAK-------------------------------- AqueK044_Aque_ATR -M-------Y-T----S--GV--DVKKL-------------------------------- AqueK045_Aque_DNAPK -S-------L-P----A--ASKM------------------------------------- AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 --------LA------K--AMQQAGSQPTAPL---------------------------- AqueK048_Aque_TRRAP -Q-------D-W----D--IL---ITLY-------------------------------- ATM_Smoe_ATM -AHTRYSVAD-W----T--FA--ECREH-------------------------------- ATR_Smoe_ATR -M-------F-T----K--ETNPTIKRI-------------------------------- DNAPK_Smoe_DNAPK -A-------A-A----K--RKEKAGDLLVE------------------------------ FRAP_Smoe_FRAP --------VP-V----N--AEHRAMV---------------------------------- SMG1_Smoe_SMG1 --------AA-Q-------LSSNAVSGA-------------------------------- GK008_Glam_FRAP --------IH-L----E--TEMQQIK---------------------------------- GK009_Glam_PIKK-Unclassified -A------EF-I----N--EQEPNED---------------------------------- TRRAP_Hsap_TRRAP ----------------------------YDRLA----------TV---------QAR-G- SMG1_Hsap_SMG1 --------------PGI-VPRPS-ELYY-SKIGPALKTV--GLSL---------D----- FRAP_Hsap_FRAP -------------------------------------------RM---------A----- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ----------------------------YDRLS----------EV---------QAR-G- CG6535_Dmel_ATM --------------------------------------------L---------S----- CG4549_Dmel_SMG1 ---------------NV-PRRFT-DLFY-NKLSPLLAKH--NMQV---------S----- FRAP_Mmus_FRAP -------------------------------------------RM---------A----- DNAPK_Mmus_DNAPK ----------------------I-RDY-KDWLM----------KV---------SGK-SD ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM --------------------------------------------M---------M----- C47D12.1_Cele_TRRAP ------------------------------------------------------A----- B0261.2_Cele_FRAP -------------------------------------------KL---------S----- atm-1_Cele_ATM ------------------------------------------------------M----- atl-1_Cele_ATR ----------------------------NTHMK--------------------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------SLK----------SL---------HDR-W- ATM_Hsap_ATM --------------------------------------------M---------M----- ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ----------------------P-CEY-KDWLT----------KM---------SGK-HD TOR_Dmel_FRAP -------------------------------------------NF---------A----- SMG1_Mmus_SMG1 --------------PSI-VPRPS-ELYY-SKIGPALKTV--GLSL---------D----- TRRAP_Mmus_TRRAP ----------------------------YDRLA----------TV---------QAR-G- smg-1_Cele_SMG1 ------------------IERPS-NMYH-NMIRLAFADHKIDSSI---------T----- TOR1_Scer_FRAP -------------------------------------------QM---------A----- TOR2_Scer_FRAP -------------------------------------------QM---------A----- TRA1_Scer_TRRAP ----------------------------ADKLN----------AA---------HDD-A- ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ----------------------S-TKYHNDWIN----------SFAKY------LKPNSP SMG1_Ddis_SMG1 QPQQNSTTTSNIVNKPI-IARPV-DIFY-AKITPLLEKA--GLNF---------M----- Tor_Ddis_FRAP -------------------------------------------QM---------C----- TRRAP_Ddis_TRRAP ---------------DLEFTNIT-E------------DNNISSSS--SSSSSSGS----- ATMa_Spur_ATM --------------------------------------------M---------H----- ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ----------------------G-ALF-TTWLQ----------KF---------CQNDGN FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ----------------------------YERLA----------VV---------QLR-G- CC1G_00839_Ccin_ATM ------------------------------------------------------L----- CC1G_08126_Ccin_ATR ------------------------------WTA----------EL---------EAQ-C- CC1G_00894_Ccin_FRAP -------------------------------------------QM---------A----- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ----------------------I-LYS-GEKVK----------QV---------LRQ-WQ AqueK043_Aque_ATM --------------------------------------------F--------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK --------------------------N-QKWLE----------QK---------FGG-SN AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 --------------QVQ-VRKPN-ELFY-AKIIPLLNEK--GLNE---------H----- AqueK048_Aque_TRRAP ----------------------------YERLA----------AL---------QTR-G- ATM_Smoe_ATM --------------------------------------------I---------V----- ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ----------------------LRNQY-HQWVE----------KK----------GGSKS FRAP_Smoe_FRAP -------------------------------------------SF---------A----- SMG1_Smoe_SMG1 --------------PPP-LPRPS-DMFY-GKIIPALKEK--GLRK---------V----- GK008_Glam_FRAP -------------------------------------------YR---------A----- GK009_Glam_PIKK-Unclassified -------------------------------------------GC---------F----- TRRAP_Hsap_TRRAP -------T--QA--S-HQ-VLRDILKEVQSNM-VPRSMLKEWALHTF--P-NATDYW--- SMG1_Hsap_SMG1 ------VS--RRDWP-LHV-MKAVLEEL-MEATPP-NLLAKELWSSC--T-TPDEWW--- FRAP_Hsap_FRAP ------PD--YDHLT-LMQ-KVEVFEHA-VNNTAG-DDLAKLLWLKS--P-SSEVWF--- mei-41_Dmel_ATR ------AV--PLHES-IER-KREVFTKQLVPAH-P-PVFQEWLRQRF--A-TPHSWY--- CG2905_Dmel_TRRAP -------T--PT--T-HT-LLREIFSEIQWTM-VPKTLLKHWALKTF--L-AATDFW--- CG6535_Dmel_ATM ------SD--HLKSP-KET-RYAIYKK-ICENI-K-PVFHYFLLEKF--P-IPGVWF--- CG4549_Dmel_SMG1 ------DP--RRQWP-ISV-LLQVLDEL-SQETPN-DLLARELWCQA--G-NAAEWR--- FRAP_Mmus_FRAP ------PD--YDHLT-LMQ-KVEVFEHA-VNNTAG-DDLAKLLWLKS--P-SSEVWF--- DNAPK_Mmus_DNAPK -AGAYVLM--YSRAN-RTE-TVVAFRR-RESQV-PPDLLKRAFVKMS--T-SPEAFL--- ATR_Mmus_ATR ------ML--PKSAA-LSE-KLKVFQELLLPRH-P-PVFHEWFLRTF--P-DPTSWY--- ATM_Mmus_ATM ------E---VQKKS-FEE-KYDTFMT-ICQNF-E-PVFRYFCMEKF--L-DPAVWF--- C47D12.1_Cele_TRRAP ------PP--RLTEA-HHI-KNIIYED-FARDMIPFRLLYDYLTARY--P-DPVMYY--- B0261.2_Cele_FRAP ------LE--TEHLT-LMQ-KLQLFESA-LSVTQG-EDLRHVLWLKS--P-SSEVWF--- atm-1_Cele_ATM ------RQ--VQTES-TET-RRQVFVE-ICQQY--SPVFRHFFYTNF--S-TAQIWR--- atl-1_Cele_ATR ------------PMG-KE-ERTKYFREVACKN-TP-VVMGKWFRIQY--P-EAGQWF--- TEL1_Scer_ATM ------KA--VQTKS-NEE-RLKAYLK-ITNEI-K-PQLRNFFFDSF--P-DPLDWF--- MEC1_Scer_ATR -----------QHTA-VDG-KLEFYME-QVDKF-PP-ILYQWFLENF--P-DPINWF--- ATM_Hsap_ATM ------E---VQKKS-FEE-KYEVFMD-VCQNF-Q-PVFRYFCMEKF--L-DPAIWF--- ATR_Hsap_ATR ------ML--PKSAA-LSE-KLKVFREFLLPRH-P-PIFHEWFLRTF--P-DPTSWY--- DNAPK_Hsap_DNAPK -VGAYMLM--YKGAN-RTE-TVTSFRK-RESKV-PADLLKRAFVRMS--T-SPEAFL--- TOR_Dmel_FRAP ------PD--YDHLT-LMQ-KVEVFEHA-LGQTQG-DDLAKLLWLKS--P-SSELWF--- SMG1_Mmus_SMG1 ------VS--RRDWP-LHV-MKAVLEEL-MEATPP-NLLAKELWSSC--T-TPDEWW--- TRRAP_Mmus_TRRAP -------T--QA--S-HQ-VLRDILKEVQSNM-VPRSMLKEWALHTF--P-NATDYW--- smg-1_Cele_SMG1 ------SD--RSKWP-AEI-LEEVFESL-TAKTPT-DLISRELWMRA--N-DATTWW--- TOR1_Scer_FRAP ------PD--YENLT-LLQ-KIEVFTYA-LDNTKG-QDLYKILWLKS--R-SSETWL--- TOR2_Scer_FRAP ------PD--YDNLT-LLQ-KVEVFTYA-LNNTEG-QDLYKVLWLKS--R-SSETWL--- TRA1_Scer_TRRAP -------L--PAPDM-TI-LKVEIFNSIQTMF-VPSNVLKDHFTSLF--T-QFEDFW--- ATR_Ddis_ATR ------VN--AKKE---KH-YLDLFE-DFNRFF-P-PVLHKHFITNF--P-EPSAWL--- DNAPK_Ddis_DNAPK VGPLYQQM--FIHAT-RDD-CAKKLEK-QHSKV-PENLLQNGIWSLS--S-SPESYL--- SMG1_Ddis_SMG1 ------TP--RSEWP-KEI-LIQVLNEL-MQETPK-WILQRELWFSS--S-SSSELF--- Tor_Ddis_FRAP ------SD--YDNLT-LLQ-KVEVFQYA-LENSNG-LDLHKVLWLKS--R-NSEVWL--- TRRAP_Ddis_TRRAP ------NSGENSPII-DSS-KLVVFREM-SKEIG--DELMINYIQSTLLPTNYQDQY--- ATMa_Spur_ATM ------AA--HQSGD-NNQ-KFRDFTT-VCRNF-Q-PVFHHFFLERF--L-DPADWF--- ATR_Spur_ATR ------IP--SLSAP-IDE-KLNIFENKLMPRY-P-PVFGEWFQKTF--T-DPTSWY--- DNAPK_Spur_DNAPK IIKLFTEA--YKKAN-ETE-TIKAFRE-REAKL-PWDLLRRGFMQLS--A-SPEAFL--- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -------S--QA--S-HQ-VLRDILKEVQTNM-VPRTLLKEWALDTF--P-TSTDYF--- CC1G_00839_Ccin_ATM ------YA--ASSRS-EED-RIKAYNE-VCAVF--KPVFRHIFTEKH--R-NPRAWF--- CC1G_08126_Ccin_ATR ----NKI----KDAQ-AAD-AGNIFVKKILPMF-PP-VFHQWFIETF--P-DPSAWL--- CC1G_00894_Ccin_FRAP ------PD--YENLM-LLQ-KVEVFEYA-LENTTG-QDLYRVLWLKS--T-NSEHWL--- CC1G_06302_Ccin_PI3K ------------------------LNYL-RVNNPD-E-------GSV--G-TSGVEP--- CC1G_04234_Ccin_PI4K ------------------------------RLGH--VTLLDHFKANYGDP-SSSRFL--- CC1G_13883_Ccin_PI4K ------------------------------------NDLMGFFVAKYGGE-NTVSFQ--- CC1G_00331_Ccin_TRRAP MV-PNKIL--SKTEY-ITL-KKDIFDE-IASKMVPDTVISNYMVRTM--D-GPVELW--- AqueK043_Aque_ATM ------AQ-----SS-KGD-KLTVYNQ-ICKHF-K-PVFHHFFMESF--P-DPALWY--- AqueK044_Aque_ATR ------LP--KDSDKRNKKVLKDIFVNKILPRH-P-PVLGEWFMKAF--P-DPTSWY--- AqueK045_Aque_DNAPK YVNWYYEM--YKKLK-ADE-VKKEYRR-IVSAV-PWDLLRRSLISLA--S-TSESFL--- AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------TP--RKEWP-LGI-QMRVLKEL-MNETPR-DLLTKELWCAS--S-CASEWW--- AqueK048_Aque_TRRAP -------E--KI--N-LT-TIKNMFSQIQMAH-APTSIIRDWAEKSC--A-SLTDFW--- ATM_Smoe_ATM --------------K-ESN-KSAAFQT-VCKNF-R-PVFRYFFRENF--S-RAADWF--- ATR_Smoe_ATR ------YE--DNKD-KKIS-ATELMRDKILPMF-P-PVFHKWFLNTF--P-EPTAWF--- DNAPK_Smoe_DNAPK VHDCYKNL--YTKVK-AGE-MEARMNA-LVAQV-PWDALKTGLYKRT--S-SAESFL--- FRAP_Smoe_FRAP ------PD--LDHLT-LIA-KVEVFQHA-LEATDG-DDLAKVFWLKS--K-TSEVWL--- SMG1_Smoe_SMG1 ------IS--RRDWP-QDV-KRKVLLDL-MKETPR-QLLYRELWCAS--D-GLKGLN--- GK008_Glam_FRAP ------PA--FMNMA-LHY-KVDAFKYM-LTTSDA-IDLCRSLWNKA--S-SAEDWL--- GK009_Glam_PIKK-Unclassified ------PT--FDL---FMA-SVTALSH-------------MEMALSK--T-HPCRFIALS TRRAP_Hsap_TRRAP -TFRKMFTIQLALIGFAEFVL--HLNRLNPEMLQIAQDTGKLNVAYF-RFDIN------- SMG1_Hsap_SMG1 -RVTQSYARSTAVMSMVGYII--GLGDRHLDNVLIDMTTGEVVHIDY-NVCFE------- FRAP_Hsap_FRAP -DRRTNYTRSLAVMSMVGYIL--GLGDRHPSNLMLDRLSGKILHIDF-GDCFE------- mei-41_Dmel_ATR -EARNTYIRTVAVMSMVGYIL--GLGDRHGENILFAEGNGDAVHVDF-NCLFN------- CG2905_Dmel_TRRAP -HFRKMLTLQLALAFLCEHAL--NLTRLNADMMYLHQDSGLM-NISYFKFDVN------- CG6535_Dmel_ATM -ERRLAYTNSVATTSMVGYVL--GLGDRHTQNILVDQQTAEVIHIDF-GIAFE------- CG4549_Dmel_SMG1 -QSVRRFVRCMSVMSMIGYVI--GLGDRHLDNVLINLGSGDIVHIDY-NVCFE------- FRAP_Mmus_FRAP -DRRTNYTRSLAVMSMVGYIL--GLGDRHPSNLMLDRLSGKILHIDF-GDCFE------- DNAPK_Mmus_DNAPK -ALRSHFASSHALLCISHWLL--GIGDRHLNNFMVAMETGSVIGIDF-GHAFG------- ATR_Mmus_ATR -SSRSAYCRSTAVMSMVGYIL--GLGDRHGENILFDSFTGECVHVDF-NCLFN------- ATM_Mmus_ATM -EKRLAYTRSVATSSIVGYIL--GLGDRHVQNILINEQSAELVHIDL-GVAFE------- C47D12.1_Cele_TRRAP -AMKKQLLHSLAVLSTIEYHC--NLTPMGPDQMMMTMNTGVLSNPSY-RFEIR------- B0261.2_Cele_FRAP -DRRTNYTRSVACMSMVGYIL--GLGDRHPSNLMLDRLTGKVVHIDF-GDCFE------- atm-1_Cele_ATM -QKIINYRQSLATWSIVCYIV--GLGDRHASNILFDQKLCTFVHIDL-GMILE------- atl-1_Cele_ATR -ASRKLFAKSTAVMSVIGYIF--GLGDRHTKNLMVH-TTGKCIHVDF-DMIFN------- TEL1_Scer_ATM -EAKKTYTKGVAASSIVGYIL--GLGDRHLNNILLDCSTGEPIHIDL-GIAFD------- MEC1_Scer_ATR -NARNTYARSYAVMAMVGHIL--GLGDRHCENILLDIQTGKVLHVDF-DCLFE------- ATM_Hsap_ATM -EKRLAYTRSVATSSIVGYIL--GLGDRHVQNILINEQSAELVHIDL-GVAFE------- ATR_Hsap_ATR -SSRSAYCRSTAVMSMVGYIL--GLGDRHGENILFDSLTGECVHVDF-NCLFN------- DNAPK_Hsap_DNAPK -ALRSHFASSHALICISHWIL--GIGDRHLNNFMVAMETGGVIGIDF-GHAFG------- TOR_Dmel_FRAP -ERRNNYTRSLAVMSMVGYIL--GLGDRHPSNLMLDRMSGKILHIDF-GDCFE------- SMG1_Mmus_SMG1 -RVTQSYARSTAVMSMVGYII--GLGDRHLDNVLIDMTTGEVVHIDY-NVCFE------- TRRAP_Mmus_TRRAP -TFRKMFTIQLALIGFAEFVL--HLNRLNPEMLQIAQDTGKLNVAYF-RFDIN------- smg-1_Cele_SMG1 -SVTKRYSRSLAVMSMVGSVL--GLGDRHLDNLLVDLKWGHVVHIDY-NICFD------- TOR1_Scer_FRAP -ERRTTYTRSLAVMSMTGYIL--GLGDRHPSNLMLDRITGKVIHIDF-GDCFE------- TOR2_Scer_FRAP -ERRTTYTRSLAVMSMTGYIL--GLGDRHPSNLMLDRITGKVIHIDF-GDCFE------- TRA1_Scer_TRRAP -LFRKQFASQYSSFVFMSYMM--MINNRTPHKIHVDKTSGNVFTLEMLPSRFPYERVKPL ATR_Ddis_ATR -DARDAFARSCAIMSMVGSVL--GLGDRHTENILLDSITGECVHIDY-NCLFW------- DNAPK_Ddis_DNAPK -FIRNSFARSLASFSVCSYVI--GIGDRHLENFLISQRDGRLIGIDF-GHAFG------- SMG1_Ddis_SMG1 -LKTQSYSRSLALMSVIGYMI--GLGDRHLDNILLDLKTGEIVHIDY-NICFE------- Tor_Ddis_FRAP -DRRTNYTRSLAVMSMVGYIL--GLGDRHPSNLMLDRHTGHILHIDF-GDCFE------- TRRAP_Ddis_TRRAP -EFKLNFSNQFGLHSLLQYILFSDIGDIDPSKIYLTKSTGSVYYNDW-SLKLT------- ATMa_Spur_ATM -EKRLSYTRSVATGSIVGYVV--GLGDRHVQNILIDCNTAELVHIDL-GIAFE------- ATR_Spur_ATR -LSRLAYARTMAVMSMVGYIL--GLGDRHGENILFDSTNGDCVHVDF-NCLFN------- DNAPK_Spur_DNAPK -TLRAHFARSHAVLCICQYIL--GIGDRHLSNFLVSLETGGMVGIDF-GHSFG------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ----QAFGRSTAVLSMIGYII--GLGDRHLDNVLVNFVTGEVVHIDY-NVCFE------- TRRAP_Spur_TRRAP -AFRKMMCGQLALLGLAEFVL--HLTRLNPEIIQIERNSGLLSVFYF-RFDLD------- CC1G_00839_Ccin_ATM -ATRLRYTRSVAASSIVGHIL--GLGDRHTSNILLDNTTGEVVHIDL-GIAFD------- CC1G_08126_Ccin_ATR -ENRTNYARTAAVMSIVGWIL--GLGDRHCENILLDVITGDAVHIDF-NCLFE------- CC1G_00894_Ccin_FRAP -ERRATYTRSLAVNSMVGHIL--GLGDRHPSNLLLERSTGKVVHIDF-GDCFE------- CC1G_06302_Ccin_PI3K -SVIDTFVRSCAGYCVVTYIL--GVGDRHLDNLLIA-PDGHFFHVDF-GYILG------- CC1G_04234_Ccin_PI4K -RAQRNFAQSLAGYSIVTYLL--QVKDRHNGNILLDR-DGHLIHIDF-GFILS------- CC1G_13883_Ccin_PI4K -KARLNFIQSMAAYSVACYIL--QIKDRHNGNIMIDG-EGHIVHIAA-CAYLT------- CC1G_00331_Ccin_TRRAP -RMRKQFTLQLATCSFMTYVF--SISSRNPSRYQVSRATGLIAMTDL-LPGLA------- AqueK043_Aque_ATM -ERRLTYTRSIATSSIVGYIM--GLGDRHVQNILIDKQSAELIHIDL-GVAFE------- AqueK044_Aque_ATR -SSSQSFARTAAVMSIVGYMV--GLGDRHGENILIDCTNGDVVHVDF-SYLFN------- AqueK045_Aque_DNAPK -LLRCTFIQSLSVINICQYIL--GIGDRHLSNFMVDMETGQLVGIDF-GHAFH------- AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 -AVTQTYCRSTAVMCMIGYII--GLGDRHLDNLLVEFTTGQVVHVDY-NVCFE------- AqueK048_Aque_TRRAP -TLRKQITRQLALVGLAEFVF--HLSRLDLEMFQISRSSGCLTQTFY-KFEIN------- ATM_Smoe_ATM -EKRLNYTRSVAASSMVGYVV--GLGDRHSMNILIDQANADVVHIDL-GVAFD------- ATR_Smoe_ATR -QSRLAYAHTTAVWSMVGHIV--GLGDRHGENILYDSTTGDCVHVDF-SCLFD------- DNAPK_Smoe_DNAPK -AMRSQFARSLSVMSICGYIA--GVGDRHLANTLIDMQTGSLVPIDF-GYSFG------- FRAP_Smoe_FRAP -ERRTNYTRSLAVMSMVGYLL--GLGDRHPSNLMLNRYSGKILHIDF-GDCFE------- SMG1_Smoe_SMG1 -KKIKRFSGSVAVMSVIGHVL--GLGDRHLDNILIDFSSGDVVHIDY-NICFE------- GK008_Glam_FRAP -LKRMNYTRSIAVSSIVGYIL--GLGDRHPANLMIERTTGMVLHIDY-GDCFE------- GK009_Glam_PIKK-Unclassified QKNQRMFATTLAHWCAVCIVT--GLGDRHSCNILIDTDDGSVHFIDF-EAVFE------- TRRAP_Hsap_TRRAP ---------DAT------G---DLDAN-----RPVPFRLTPNISEFLTTIGVS--G--P- SMG1_Hsap_SMG1 ---------KGK----------SLRVP-----EKVPFRMTQNIETALGVTGVE--G--V- FRAP_Hsap_FRAP ---------VAM------T---REKFP-----EKIPFRLTRMLTNAMEVTGLD--G--N- mei-41_Dmel_ATR ---------QGE----------LLPYP-----EVVPFRLTHNMIVAMGPLGVE--G--S- CG2905_Dmel_TRRAP ---------DDK------C---QLNQH-----RPVPFRLTPNVGEFITHFGIT--G--P- CG6535_Dmel_ATM ---------QGK----------IQTTP-----ETVPFRLTRDFVAPMGICGTK--G--V- CG4549_Dmel_SMG1 ---------KGR----------TLRIP-----EKVPFRLTQNLVQAMGITGIE--G--P- FRAP_Mmus_FRAP ---------VAM------T---REKFP-----EKIPFRLTRMLTNAMEVTGLD--G--N- DNAPK_Mmus_DNAPK ---------SAT------Q---FLPVP-----ELMPFRLTRQFVSLMLPMKET--G--L- ATR_Mmus_ATR ---------KGE----------TFEVP-----EIVPFRLTHNMVNGMGPMGTE--G--L- ATM_Mmus_ATM ---------QGK----------ILPTP-----ETVPFRLSRDIVDGMGITGVE--G--V- C47D12.1_Cele_TRRAP ---------GGR------SLHDIQHFG-----HEVPFRLTPNLSILVGVA-QD--G--D- B0261.2_Cele_FRAP ---------VAM------L---REKFP-----ERVPFRLTRMLINAMEVTGLD--G--V- atm-1_Cele_ATM ---------YSK------R---TLPVP-----EQVPFRITRDVLDPILIEGIEN-G--Q- atl-1_Cele_ATR ---------K-G------E---TLGTP-----ELVPFRLTQNMINGMGEVALD--G--E- TEL1_Scer_ATM ---------QGK----------LLPIP-----ELVPFRLTRDIVDGFGVTGVD--G--L- MEC1_Scer_ATR ---------KG-------K---RLPVP-----EIVPFRLTPNLLDALGIIGTE--G--T- ATM_Hsap_ATM ---------QGK----------ILPTP-----ETVPFRLTRDIVDGMGITGVE--G--V- ATR_Hsap_ATR ---------KGE----------TFEVP-----EIVPFRLTHNMVNGMGPMGTE--G--L- DNAPK_Hsap_DNAPK ---------SAT------Q---FLPVP-----ELMPFRLTRQFINLMLPMKET--G--L- TOR_Dmel_FRAP ---------VAM------T---REKFP-----EKIPFRLTRMLIKAMEVTGIE--G--T- SMG1_Mmus_SMG1 ---------KGK----------SLRVP-----EKVPFRMTQNIETALGVTGVE--G--V- TRRAP_Mmus_TRRAP ---------DAT------G---DLDAN-----RPVPFRLTPNISEFLTTIGVS--G--P- smg-1_Cele_SMG1 ---------KGK----------NLRIP-----ETVPFRLTRNMRHALGPSEMY--G--T- TOR1_Scer_FRAP ---------AAI------L---REKYP-----EKVPFRLTRMLTYAMEVSGIE--G--S- TOR2_Scer_FRAP ---------AAI------L---REKFP-----EKVPFRLTRMLTYAMEVSGIE--G--S- TRA1_Scer_TRRAP LKNHDLSLPPDS------P---IFHNN-----EPVPFRLTPNIQSLIGDSALE--G--I- ATR_Ddis_ATR ---------KGE----------TFTVP-----ERVPFRLTRNMVDVFGVLGVE--G--T- DNAPK_Ddis_DNAPK ---------TAT------Q---FLPIP-----ELMPFRLTRQFTSFLRPLDSV--G--L- SMG1_Ddis_SMG1 ---------KGA----------ELKIP-----ERVPFRMTQIFEYALGLTGVQ--G--T- Tor_Ddis_FRAP ---------VAM------H---RDKYP-----EKIPFRLTRMLINAMEVSGIE--G--N- TRRAP_Ddis_TRRAP ---------NRKLGFDLLQ---DNPYN-----QQQLLRLSPNIRNYLGPLYLE--G--S- ATMa_Spur_ATM ---------QGR----------NLPTP-----ETVPFRLTRDLVDAMGVAGVE--G--V- ATR_Spur_ATR ---------KGE----------TFDWP-----ERVPFRLTHNMVCAMGPMGYE--G--V- DNAPK_Spur_DNAPK ---------SAT------Q---FLPIP-----ELIPFRVTRQIINLMLPMKID--G--V- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ---------KGK----------NLRVP-----ERVPFRMTQNVQAALGITGV-------- TRRAP_Spur_TRRAP ---------ETS------G---ELDAN-----RPVPFRLTPNIAEFLTTVGVN--G--M- CC1G_00839_Ccin_ATM ---------QGK----------LLTIP-----ELVPFRLTRDMVDGMGISGTQ--G--V- CC1G_08126_Ccin_ATR ---------KG-------K---VLLTP-----ERVPFRLTQNIVDGLGVTGVE--G--M- CC1G_00894_Ccin_FRAP ---------VAM------H---REKFP-----EKVPFRLTRMLTHAMEVSGIE--G--S- CC1G_06302_Ccin_PI3K ---------RDP----------K-PFP-------PAVKVCKEMVDGMGGAQSPHYM--R- CC1G_04234_Ccin_PI4K ---------NTP----------GNIGF-----EAAPFKFPLEYLEVLGGIDGA--GYKE- CC1G_13883_Ccin_PI4K ---------L-V------A---LILRPGGVKFEPNSFKLNHEMVQLMGGRYSQ--G--YQ CC1G_00331_Ccin_TRRAP ---------THL------P---VFATT-----DTVPFRFTPNLQHFVGPVFTD--G--I- AqueK043_Aque_ATM ---------QGR----------ALPTP-----EVIPFRLTRDLVSGMGITGVV--G--V- AqueK044_Aque_ATR ---------KGL----------TLEVP-----EIVPFRLTHNMVDAMGVTKYE--G--T- AqueK045_Aque_DNAPK ---------SAT------Q---FLPLP-----ELMPFRLTPQFVNLLLPHKVS--G--Q- AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ---------KGK----------SLRVP-----ERVPFRMTQNIENALGFTGVE--G--L- AqueK048_Aque_TRRAP ---------N-E------G---ALDAN-----RAVPFRLTPNIQSFLSPIGIS--G--P- ATM_Smoe_ATM ---------QGL----------MLKTP-----ETIPFRLTRDVIDGMGVTGVE--G--V- ATR_Smoe_ATR ---------KGL----------QLEKP-----ELVPFRLTQNMVDGLGITGYE--G--V- DNAPK_Smoe_DNAPK ---------TGV------I---LLPVP-----ELIPFRLTPQLTNVLLPLDSL--G--L- FRAP_Smoe_FRAP ---------AAM------T---REKFP-----EKVPFRLTRMLVKAMEVSGIE--G--N- SMG1_Smoe_SMG1 ---------KGR----------RLKVP-----EIVPFRLTQTIQNALGPTGVE--G--F- GK008_Glam_FRAP ---------VAM------H---REQLP-----EKVPFRLTSIMMKAFESCGTE--G--S- GK009_Glam_PIKK-Unclassified ---------YPK----------LLSYA-----ELVPFRLTALIAQLLGPTGIH--G--C- TRRAP_Hsap_TRRAP -LTASMIAVARCF-AQPNFKVDGILKTVLRDEIIAWHKK-TQEDT--SSPLSAAG----- SMG1_Hsap_SMG1 -FRLSCEQVLHIM-RRGRETLLTLLEAFVYDPLVDWTAG-GEAGFAGAVYG--------- FRAP_Hsap_FRAP -YRITCHTVMEVL-REHKDSVMAVLEAFVYDPLLNWRLM-DTNTK--GNKRSRTR----- mei-41_Dmel_ATR -FRKCCEITLRLL-KQESKTLMSILRPFVYDVGAQTRKG-AA-----T------------ CG2905_Dmel_TRRAP -LSAAIVATARCF-IQPNYKLSSILQTILRDEIIALQKK-GFREC--KLIEGSED----- CG6535_Dmel_ATM -FAKSCEATMHIL-RRYKSVFTTILEVLLYDPLFIWGVL-KKKQS--PQQS--------- CG4549_Dmel_SMG1 -FRLGCEYVLKVM-RKERETLLTLLEAFVYDPLVDWTTN-DDAQA--LRRS--------- FRAP_Mmus_FRAP -YRTTCHTVMEVL-REHKDSVMAVLEAFVYDPLLNWRLM-DTNTK--GNKRSRTR----- DNAPK_Mmus_DNAPK -MCTVMVHALRAF-RSCAGLLTDTMEIFVKEPSFDWKSF-EQTML--RKGGSWIQ----- ATR_Mmus_ATR -FRRACEVTLRLM-RDQREPLMSVLKTFLHDPLVEWSKP-VKGHS--KAPLNETG----- ATM_Mmus_ATM -FRRCCEKTMEVM-RSSQETLLTIVEVLLYDPLFDWTMN-PLKAL--YLQQRPED----- C47D12.1_Cele_TRRAP -LLWSMAAASKCLMKKEPEVI---MRPLVWDEFANNTDC-DKSVF--A------------ B0261.2_Cele_FRAP -YNYTAERVLKML-RTNQESLLAVLEAFVYDPVINWRLV-EGMKK--DPKTR-KD----- atm-1_Cele_ATM -LAEECTQIMEKL-KENGKVILGVASALLRETMTNFREA-EQAAG--R------------ atl-1_Cele_ATR -FRTVCEQALRVF-RENSYEIEKYIADLP-NLVADFPSN-KRAPK--D------------ TEL1_Scer_ATM -FRRSCERVYAVL-RKDYVKVMCVLNILKWDPLYSWVMS-PVKKY--EHLFEEEH----- MEC1_Scer_ATR -FKKSSEVTLALM-RKNEVALMNVIETIMYDRNMDHSIQ-KA------------------ ATM_Hsap_ATM -FRRCCEKTMEVM-RNSQETLLTIVEVLLYDPLFDWTMN-PLKAL--YLQQRPED----- ATR_Hsap_ATR -FRRACEVTMRLM-RDQREPLMSVLKTFLHDPLVEWSKP-VKGHS--KAPLNETG----- DNAPK_Hsap_DNAPK -MYSIMVHALRAF-RSDPGLLTNTMDVFVKEPSFDWKNF-EQKML--KKGGSWIQ----- TOR_Dmel_FRAP -YRRTCESVMLVL-RRNKDSLMAVLEAFVYDPLLNWRLL-DVDKK--GNDAV-AG----- SMG1_Mmus_SMG1 -FRLSCEQVLHIM-RRGRETLLTLLEAFVYDPLVDWTAG-GEAGFAGAVYG--------- TRRAP_Mmus_TRRAP -LTASMIAVARCF-AQPNFKVDGVLKTVLRDEIIAWHKK-TQEDT--SSPLSAAG----- smg-1_Cele_SMG1 -FRESCVHVLSTL-RSGHQVLTMLLDAFVFDPLVDWTSH-EHTAT--SGVSLALQLAVYG TOR1_Scer_FRAP -FRITCENVMRVL-RDNKESLMAILEAFALDPLIHWGFD-LPPQK--LTEQTGIP----- TOR2_Scer_FRAP -FRITCENVMKVL-RDNKGSLMAILEAFAFDPLINWGFD-LPTKK--IEEETGIQ----- TRA1_Scer_TRRAP -FAVNLFTISRAL-IEPDNELNTYLALFIRDEIISWFSN-LHRPI----IENPQ------ ATR_Ddis_ATR -FKTVCENTLRVL-RSNKEVLLRVLENFIYDPFLILFDKKNQNSN--NNNNTHFG----- DNAPK_Ddis_DNAPK -LNHNMTYTLTAL-QNQKEILLTTMDVFVKEPLLDWSKL-ATRLV--KEQGKHP------ SMG1_Ddis_SMG1 -FRETSIQIMHLL-RKNKDILLNLLETFIYDPLFDWKHS-NKQTN--NNNN--------- Tor_Ddis_FRAP -FRLTCEAVMNVL-RNNKESLMAVLEAFVHDPLINWRLL-TPNEN--NTKHKATN----- TRRAP_Ddis_TRRAP -YLSSMISTCICL-SDLKDQLVNSINLFIFDEYMCMNNV-EPLQQ--SEQNKDR------ ATMa_Spur_ATM -FRRCSEKTMEEM-HNSREALLTVVEVLLYDPLYTWTMS-PARAL--ELQALDRT----- ATR_Spur_ATR -FRRACEGTMKVM-RDQRDPLMSVLKTFIYDPLVEWSKP-SRGRS--N-ALSESG----- DNAPK_Spur_DNAPK -LQSTMVHTLRAL-RQNHELLVNTMDVFVKEPSLDWKCF-AVKQA--DYQKL--S----- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP -LNACMISIARCL-VQPSFQLPAILKAVLRDEMIAWSKK-TSLSL--------------- CC1G_00839_Ccin_ATM -FQRCAEETLRVL-RDGSDIIMTVLEVFKHDPLHSWTAS-EIKIK--RVQQPEAP----- CC1G_08126_Ccin_ATR -FRIACELTMDLL-RNNMDSLMSVLDAFIHDPLVEWEDE-KRKQE--NRSRRSAQ----- CC1G_00894_Ccin_FRAP -FRNTCEITMTVL-RDNKESLMAVLEAFVYDPLINWRLM-QADVE--VRRPD-AD----- CC1G_06302_Ccin_PI3K -FKNYCFTAFSIL-RKSANLILNLVALMVDANIPDIKHR-DVHE---------------- CC1G_04234_Ccin_PI4K -FKRLFREGFEAA-RKHCDRIITLVELMQKDSSYPCFAV-SADQT--A------------ CC1G_13883_Ccin_PI4K LFQSLTVKAFLAI-RPYAAQIVDTVQLMLDTGLPSFKG---------------------- CC1G_00331_Ccin_TRRAP -LATGIMSVGQAL-TEPEFDLEYHLCLFSRDEVGAWMGM-RGKPF--NIDQIFRQ----- AqueK043_Aque_ATM -FQRCCEETMEVM-RSSHEELRTIVEVLLHDPLYIWTIS-NKKAR--HIQSSTAV----- AqueK044_Aque_ATR -FRISCEMTMKLM-RQQRDPLMCVLKTLIHDPLVEWVVK-TSRSQ--SS----------- AqueK045_Aque_DNAPK -LRSCMIHTLRAL-RHSPTLLLNTMDVFIKEPSLEWESN-AKKQA--LAQKI-------- AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 -FRISCEDILRIL-RRGRETLLTLLEAFVYDPLIDWTQS-EEAAFPLAMRT--------- AqueK048_Aque_TRRAP -LYMSMVAVARVL-VQPQYSIESILLALFRDEFIAWSKR-KQEEA--EGHFVSLA----- ATM_Smoe_ATM -FRRCCEATLSVL-RANKEALLTIIEVFIHDPLYRWALS-PLKAL--QRQEYAD------ ATR_Smoe_ATR -FLRTCEITLSVL-RANRETLMSVLETFIHDPLVEWTKS-HKSSA--TEVQNPHA----- DNAPK_Smoe_DNAPK -LKNDMVRVLSAL-HKSRQMICAVMDVFVREPLVDWKKE-AARTA--SIRGGE------- FRAP_Smoe_FRAP -FRSICEDVMHVL-RSNKDSVMAMMEAFVHDPLINWRLF-NINDV--PAS-M-AT----- SMG1_Smoe_SMG1 -FRASCEAVLSVL-QKNKEVILMLLEAFVWDPLVEWMRG-DGHDE--ATIG--------- GK008_Glam_FRAP -FRMTGEATMSIL-RSNKDSLVSVLETFIYDPLMSMKVL-SGENT--MGGKENID----- GK009_Glam_PIKK-Unclassified -FYWELVKMVSLI-QENAPAFINVFYPLAI---VRA------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 --------------------GGGQQAESKQSKREMEREITRSLFSSRVAEIKVNWFKNRD FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 LNAKLQESADGGGAGGLGVGDLKYHKKDKNKGKPLDSDVKRQPFLSKLGMLQKYWSTNKT FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 --------------------GGGQQAESKQSKREMEREITRSLFSSRVAEIKVNWFKNRD TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 S--------------------N-----WKTKAKERL-TDAMELLNLRMSEVQTLWLANRD TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ----------------------TTELGVRQTRKEMEWEVAEGMLITKLAESEPHWQKNRE AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 --------------------G--------EERKGMELAVSLSLFASHVQENRVALQEHHD GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 EMLVVLPKLDGSLDEYLSLQEQLTDVEKL------QGKLLEEIEFLEG-A---------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ELMPQLEEMEQEVGNLQAAQAKQVVAEEELVKLNQRSALIAEIKSLGT------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 EMLVVLPKLDSSLDEYLSLQEQLTDVEKL------QGKLLEEIEFLEG-A---------- TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 DLLHWMKQVTE------------------------------------------------- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 NLCSVLLALEKHLNDIALTSEQMVGYQEK------IGKLDKEISILTEAV---------- AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 QLLRTLPTIPSTLQSWAAGYENFERCSTL------AYHINQKKYAAEN-AEVAARNLLAE GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ----EGVDHPSHTL------QHRYSEHTQLQ----------------------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ----AIESHSFNTASLRNAVRRGHSEALALLSTERLPDFGRVQCILRSYGQCLQLYHLLD FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ----EGVDHPSHTL------QHRYSEHTQLQ----------------------------- TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 --------------------------CL-------------------------------- TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ----STPNHPLISM------QDRLSEQSRLS----------------------------- AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ASGSLEKTHVTYEI------QAREFAQSKARTAEA------------------------- GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 --TQQRAVQEAIQVKLNEFEQWITHYQAAFNNL---------------EATQLASLLQEI FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 LQGQ------------------------------------------------LVKLQMES FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 --TQQRAVQEAIQVKLNEFEQWITHYQAAFNNL---------------EATQLASLLQEI TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 --AEQKRLLSLIKEKYDDSLEWNQKYKSVFTSL---------------HSTDKETTLQKL AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ---------------ARETTQWIEQRSRVLDSLRTDTAPELQALGQRTHSTEAVSLLQAI GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 STQ----MDLGPPSYVPATAFLQNAGQAHLISQCEQLEGEVGALLQQRRSVLRGCLEQLH FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 NSE-------NAREFSALTEALQLSG-------LDSMRSQLNELLGRMDMVAQKSSKHLQ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 STQ----MDLGPPSYVPATAFLQNAGQAHLISQCEQLEGEVGALLQQRRSVLRGCLEQLH TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 AAMMREPLDLGSSGHEPAVEFLQKTGQAHTVESCDQLEDELVSLLQRRRTVIHGALEALN AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 VASGVALTVL------------PEPTQVHF----REVDRDISQFTSARHEALLHARATLQ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 HYATVALQ--YPKAIFQKHRI------EQWKTWMEELICNTTVERCQELYRKYEMQYAPQ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 EYAGVMNF--YPE---QSHRQNLFVRFHDSFATYIQN----------------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 HYATVALQ--YPKAIFQKHRI------EQWKAWMEELICNTTVERCQELYRKYEMQYAPQ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 QYRVITSQ--FPTRYLEQSRS------YLWEHCLDEIVNSSTEIHHDQFIKIVESFESLL AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 AYA-VALQRLLPGNYYTTSYV------HSWAKILQLLSMQVT-PEVLGVTKRQAIDITAG GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 PPPTVCQFITATEMTLQRYAAD-------------------------------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 -----------------GYTADSTTNTNSPSSSIICKADVVGVAEAMEYSWERLGCQLHE FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 PPPTVCQFITATEMTLQRYAAD-------------------------------------- TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 GPSPPTRLIMATDNKL-------------------------------------------- AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 GRGDHDDVICQKHEKLRSHVELLGEEVQKLEQGRLQLEESVDPDAEKRAKDKLMGIFL-- GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ---------------------------------------INSRLIRQVE----------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ASKLYAANQAQALTLGAPTTALLSMIVQSGCSQLLLKASL-------------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ---------------------------------------INSRLIRQVE----------- TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 --------------------------------------------RKQIQEQGTKFQKCDQ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 LEDELVSLLQRRRTVIHGALEALNQYRVITSQFPTRYLEQSRSYLWEHCLDEIVNSSTEI AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 HHDQFINIVESFESLLGPSPPTRLIMATDNKLRKQIQEQGTKFQKLTERAQALSSIDMKE AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------VRTL------------------------D---------RAGG FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 LDLTVKEAHQNLQKFCQGKRWL------------------------Y---------MEQT AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 -------------------RSLQQGKKDEDDAGLYDFEERRLKVILVLQSAASTIYSEIG GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 -----------------RLKQEAVTVPVCEDQLKEIERCIKVFLHENGEEGSLSLASVII FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 AFAAYEQVA--------------------------------------------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 -----------------RLKQEAVTVPVCEDQLKEIERCIKVFLHENGEEGSLSLASVII TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ARTARDRLSDLTSREGDW------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 NHAANLQGVGMEES---------------------------------------------- GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 SALCTLTRRNLMMEGAASSAGEQLVDLTSRDGAWFLEELCSMSGNVTC------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 --------------------------LASHDDGLLH------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 SALCTLTRRNLMMEGAASSAGEQLVDLTSRDGAWFLEELCSMSGNVTC------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ----------------------------------FMDELCTMGGNVFQ------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------IRRWCFPELEGLVERAVLVSDVLNELQQFS GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ---------------------------LVQLLKQCH-----LVPQDLDIPNPMEASETVH FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ---------------------------LVQLLKQCH-----LVPQDLDIPNPVEASEAVH TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ---------------------------MSSTLETCLSYLGHDIQSDTLVRSCLD---SVA AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 GKATGYRANPWDSNSSFTAELKGFTDCL-------------------------------- GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 LANGVYTSLQ---ELNSNFRQIIFPEALRCLMKGE-YTLESMLHELDGLIEQTTDGVPL- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 -------------------HQLLFIHLVRTMLQGVLVM--------------------TK FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 LANGVYTSLQ---ELNSNFRQIIFPEALRCLMKGE-CTLESMLHELDSLIEQTTDGVPL- TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 AVHSVYSSML---DLVNKFYSLVMPEVSKSIISDD-PSFVQMLDDVADIKLTMFPELPL- AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ---------AGIDHLVKQMIGVVLPEAVKAALSQD-PAVMD------------------- GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 -------------------------------------QTLVESLQ--------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 EEDQHLAQLESLLSALSHLKKMFEYDLPANLYRLLLLQ---------------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 -------------------------------------QTLVESLQ--------------- TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 -------------------------------------PDALRKLI--------------- AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 --------------------------------------AFASLSQIRGAIDTTLEKVAEI GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 -------------------------AYLRNAAMG-------LEEETHAHYIDVARLLHAQ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 -------------------------AYLRNTAMG-------LEEETHAHYIDVARMLHAQ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 -------------------------EHLRQCALK-------NVPADLTTTAAVEDLKNKL AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 EMQKSALLELERTYPDRLEELVKRKTFLEEAAAGGKDDLSWEE----------------- GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 YGELIQPRNGS----------------------------------------VD------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------PNLGK----------------------------------------LS------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 YGELIQPRNGS----------------------------------------VD------- TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 STIMFSSECEE----------------------------------------GH------- AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------AEELASQEDLCREQLETLQKAWSQRSAQASAVLRMEGLVRSALASADQRFEALV GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ----ETPKMSAGQMLLVAFDGMFAQVETAFSLLVEKLNKMEIPIAWRKID---------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ----ALCHLSASSLA----------------------------------QLFLEATMENG FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ----ETPKMSAGQMLLVAFDGMFAQVETAFGLLVEKLNKMEIPVAWRKID---------- TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ----DTPSLTQAQVILNGLNSLFEAVESQTLNMLDQVEEITVPDEWRNTD---------- AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ALDRDDLHLMRGKVLLAAFAKLFSGLESLDA----------------------------- GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------IIREARSTQVNFFDDDNHRQVLE---------------EIFFLKRLQTIKEFFR FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 HKPPDQF-----------------------------------PVERRFLLTLQPVYDQFL FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------IIREARSTQVNFFDDDNHRQVLE---------------EIFFLKRLQTIKEFFR TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------LVK-------------------QTKEVMCTTAGLFLKEDLLFVRKVSSIVDFCS AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 LCGTFSKTLSGSSSLEDQNTVNGPVQIVNVKTLFRNSCFSED------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 LASTSLDSLVSSMQSMLEDVHDVQTQQIMELGL-MRSC---HTELNDECFFGLVSEALES FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 LCGTFSKTLSGSSSLEDQNTVNGPVQIVNVKTLFRNSCFSED------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ECKNLMKAFKLELTSDGGGEYLSLVSPPGTPSKRSSSSVPVP------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------ALRRVPV----------------------------------- GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 -------QMAKPIKAFTADFVRQLLIGLPNQALGLTLCSFISALGVDIIAQVEAKDFGAE FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 SRTCDVREMARPMLGFIHRLQVEKLAG----LLPILTRNF-----YTAVGPQCLPTASCG FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 -------QMAKPIKAFTADFVRQLLIGLPNQALGLTLCSFISALGVDIIAQVEAKDFGAE TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 -------TDQQLSHPIRRYISETLICHVLGQPSYALTCLLVCTVTQYLEAPIQFGKP--- AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 SKVSVDDLCKKAVEHNIQIGKFSQLVMNRATVLAS------------------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 DPAQADHLCE---------------------SLFISLQSDGALLQQQAEIALLSQQVDLH FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 SKVSVDDLCKKAVEHNIQVGKFSQLVMNRATVLAS------------------------- TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 --TTIEEMCKVANEHCQSML--PLGVVQHARTLFS------------------------- AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ---SYDTAWKKHD----------------------------------------------- FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 TLAASAQYWAYSEALGSQLRCGPHIVSRPKLTAAIGECWLELDQKLTALQQLQAGLESQL FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ---SYDTAWKKHD----------------------------------------------- TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ---HHDVAWREWD----------------------------------------------- AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 SQLQTQRSNWNRNHIDNLLRMEQCNKQRTMSHVALLQKMTDGAGAVARLEQNAIVVGEEG FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 --LVRRLETSISSCKTSLQRVQLHIAMFQWQHEDLLINRPQAMSVTPPPRSAILTSMKKK FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 QALVDHLEQWL------------------------------------------------- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 --LVRRLETSISSCKTSLQRVQLHIAMFQWQHEDLLISRPQAMSVTP-PRSAILTSMKKK TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 --KARRLTTNLENCKQSIQRLKNITMRFQWLHEESLIVPDAVHTWVVQQRSALLTVIKKV AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 LHTLSQIETSIATVQEKLAALESSIEQRLKWAGGANPALAPVLQDFEATIAERRNLVLKE FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 -------------------------------------------------------AAHGQ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 LHALSQIETSIGTVQEKLAALEASIEQRLKWAGGANPALAPVLQDFEATIAERRNLVLKE TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 LSE--QLATSIGNVIEKIHSQQFRISQRLQWAAGANSSLNKVIDEFQRACNHHKTMLERE AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 SQRASQVTFLCSNIIHFESLRTRTAEALNLDAALFELIKRCQQMCSFASQFNSSVSELEL FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 W----------------------------------------------QASSSRISAVEQS FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 SQRANQVTFLCSNIIHFESLRTRTAEALSLDAALFELIKRCQQMCSFASQFNSSVSELEL TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ESIFIEMEEMAKAIIHLESSHTRIPAQTSSD----------RETIQILQRCSDVTVKLKL AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ----------------------------------------------------AKTMQVES GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 -------------------RLL------------------QRVDT-----------GLEH FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 MVELLDPEGAIDHYWLENVQGL------------------LE------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 -------------------RLL------------------QRVDT-----------TLEH TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 CGEEL----------TQLSDIM------------------PHLQLPSDGSPLNKEWIQ-- AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 PGLEYIWRA--SNVLQKKTFFVWKVYVMDILLDSCVRDASN------------------- GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 PIGSSEWLLSAHKQLTQDMSTQRA-------IQTEKEQQIETVCETIQNLVDNIKTVLTG FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 --------------------------------------------EQTCKVHREIAAIEGE FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 PIGSSEWLLSAHKQLTQDMSTQRA-------VQTEKEQQIETVCETIQSLVDSVKTVLTG TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------KRLDEATSERTKLQGDKKFSNN----KVVKNKENVLSELEKLRSLNRQ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 HNRQLGDVKHLL------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 QQSKHRFICTLLKETLRLLENMPRFHVQSLCSEAQAQGQGKMEYANVQLLSDHLREGQGL FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 HNRQLGDVKHLL------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 HRKLLVEVWQQLTS-LAKLEDPPAAGQLQPGPRAFINHQNRFGEE--------------- AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ---------------------------KAMAKDEEAALADGEDVPYENSVR---QFLGEY FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 MQSLYMRLQELRKDICSDRRVLQPSML------------------QNWRHQLEMI----- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ---------------------------KAMAKDEEAALADAEDIPYESSVR---QFLAEY TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ---TKSFIQSTQDL-----------IASDMSLT---------------SKP---SWTSKA AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 KSW---------------------QDNIQTVLFTLVQAMGQVRSQEHVEMLQEITPTLKE FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 --LTLAKQEVNE-FFKGLEDFMQH--------------------------AGETDS---- FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 KSW---------------------QDNIQTVLFTLVQAMGQVRSQEHVEMLQEITPTLKE TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 RAEEFRQLGTMAVNLRGLAEWILGQLLSFTEQLFINPYSSKLKWH--EPLQLESS----- AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -----------------------------------------QPE-N-------------- SMG1_Hsap_SMG1 LKTQSQSIYNNLVSFASPLVTDATNECSSPTSSATYQPSFAAAV-RSN----------T- FRAP_Hsap_FRAP -----------------------------------------TDS-Y-S----------A- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP -----------------------------------------RYS-D-------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -----------------------------------------TDS-Y-S----------A- DNAPK_Mmus_DNAPK -----------------------------------------EIN-V-------------- ATR_Mmus_ATR -----------------------------------------EVV-N-------------- ATM_Mmus_ATM -----------------------------------------ESD-LHS----------TP C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP -----------------------------------------TGG-R-------------- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM -----------------------------------------EIT-N------------F- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -----------------------------------------ETE-LHP----------TL ATR_Hsap_ATR -----------------------------------------EVV-N-------------- DNAPK_Hsap_DNAPK -----------------------------------------EIN-V-------------- TOR_Dmel_FRAP -----------------------------------------A-G-APGGRGGSGMQDSL- SMG1_Mmus_SMG1 LKTQSQSIYNNLVSFASPLVTDAANECSSPTSSATYQPSFAAAV-RSN----------T- TRRAP_Mmus_TRRAP -----------------------------------------QPE-N-------------- smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP -----------------------------------------LPL-IN------------- TOR2_Scer_FRAP -----------------------------------------LPV-MN------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR -----------------------------------------EV----------------- DNAPK_Ddis_DNAPK -----------------------------------------K-D---------------- SMG1_Ddis_SMG1 -------------------------------------NNNNNNM-NQA----------A- Tor_Ddis_FRAP -----------------------------------------IAS-NNS----------T- TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM -----------------------------------------EMG-DQS----------EL ATR_Spur_ATR -----------------------------------------EIN-N-------------- DNAPK_Spur_DNAPK -----------------------------------------EDS-R-------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM -----------------------------------------PTTPASE----------A- CC1G_08126_Ccin_ATR -----------------------------------------QVP-V-------------- CC1G_00894_Ccin_FRAP -----------------------------------------VER-VPE----------L- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -----------------------------------------SMI-A-------------- AqueK043_Aque_ATM -----------------------------------------EWA-G-------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK -------------------------------------------N-T-------------- AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 -------------------------------SISLKNRSSSLSV-ASQ----------S- AqueK048_Aque_TRRAP -----------------------------------------DVS---------------- ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -----------------------------------------QVT-G-------------- DNAPK_Smoe_DNAPK -----------------------------------------E-E---------------- FRAP_Smoe_FRAP -----------------------------------------IRA-Q-T----------A- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -----------------------------------------GNT-E-F----------Y- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -------------M---------------------------------------------- SMG1_Hsap_SMG1 -------------G---QKTQP----DVMSQ---NARKLI-------------------- FRAP_Hsap_FRAP -------------G---Q-S-V----EIL-D-GV---------ELGEPAHK-KTGTT--V mei-41_Dmel_ATR -------------A---------------------------------------------- CG2905_Dmel_TRRAP -------------G---------------------------------------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -------------G---Q-S-V----EIL-D-GV---------ELGEPAHK-KAGTT--V DNAPK_Mmus_DNAPK -------------T---------------------------------------------- ATR_Mmus_ATR -------------E---------------------------------------------- ATM_Mmus_ATM NADD---------Q---------------------------------------------- C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -------------F---------------------------------------------- TEL1_Scer_ATM -------------D---------------------------------------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM NADD---------Q---------------------------------------------- ATR_Hsap_ATR -------------E---------------------------------------------- DNAPK_Hsap_DNAPK -------------A---------------------------------------------- TOR_Dmel_FRAP -------------S---N-S-V---------------------EDSLPMA---------- SMG1_Mmus_SMG1 -------------G---QKTQP----DVMSQ---NAKKLI-------------------- TRRAP_Mmus_TRRAP -------------M---------------------------------------------- smg-1_Cele_SMG1 --------------------------------LIENSMLGANAIY-AQQRV-KAGTE--L TOR1_Scer_FRAP --------------------------------PS---------ELL------RKGAI--T TOR2_Scer_FRAP --------------------------------AN---------ELL------SNGAI--T TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -------------T---------------------------------------------- SMG1_Ddis_SMG1 -------------G---E---Q----ESI-E-KKQSSNNSSNPIISTPTKL-QQQQK--L Tor_Ddis_FRAP -------------SNSTT-K-IEGDLNTI-DNPI---------NKESPDHEAVAGSLKSS TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM NTTTDGHQDILHPT---------------------------------------------- ATR_Spur_ATR -------------E---------------------------------------------- DNAPK_Spur_DNAPK -------------E---------------------------------------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM -------------G---AN----------------------------------------- CC1G_08126_Ccin_ATR -------------T---------------------------------------------- CC1G_00894_Ccin_FRAP -------------G---R-------------------------VAAHPQA---------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP -------------N---------------------------------------------- AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK -------------D---------------------------------------------- AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 -------------G---QQDS---------E---QQS-RI-------------------- AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR -------------P---------------------------------------------- DNAPK_Smoe_DNAPK -------------S---------------------------------------------- FRAP_Smoe_FRAP -------------T---Q-N-L----E----------------AVGLPSP---------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP -------------G---T-R---------------------------------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP PE---------------------------------------------------------- mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP PE---------------------------------------------------------- DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ----------------------------------------------------------Q- atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP KS--------------------------------------K------PY--D-----P-- SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 REAVTRHHALAKELRPLIRVIGKEREEFADYLKFYKQALFDPLLKGHSALRNELDID--- TOR1_Scer_FRAP VE---------------------------------------------------------- TOR2_Scer_FRAP EE---------------------------------------------------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 PN--------------------------------------SP--------LSI---SSNN Tor_Ddis_FRAP PV--------------------------------------H----GRQI--A-----RN- TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP PN--------------------------------------R----KLKA--D-----EN- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP PQ--------------------------------------R----GA----R-----ER- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ----------------------------------------R------------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -------------------------------------------D---------------- SMG1_Hsap_SMG1 ----------------------------------------------------QKNLATSA FRAP_Hsap_FRAP -------------------------------------------S--I------------- mei-41_Dmel_ATR -------------------------------------------K---------------- CG2905_Dmel_TRRAP -------------------------------------------N---------------- CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP -------------------------------------------S--I------------- DNAPK_Mmus_DNAPK -------------------------------------------E---------------- ATR_Mmus_ATR -------------------------------------------K---------------- ATM_Mmus_ATM -------------------------------------------E--C------------- C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR -------------------------------------------D---------------- TEL1_Scer_ATM -------------------------------------------N--V------------- MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM -------------------------------------------E--C------------- ATR_Hsap_ATR -------------------------------------------K---------------- DNAPK_Hsap_DNAPK -------------------------------------------E---------------- TOR_Dmel_FRAP -------------------------------------------T--L------------- SMG1_Mmus_SMG1 ----------------------------------------------------QKNLATSA TRRAP_Mmus_TRRAP -------------------------------------------D---------------- smg-1_Cele_SMG1 -----------------------------TCVYNFNIVMQNIDN--V-----FGALVNLS TOR1_Scer_FRAP -------------------------------------------E--A------------- TOR2_Scer_FRAP -------------------------------------------E--V------------- TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK -------------------------------------------K---------------- SMG1_Ddis_SMG1 TNSTNNNNNNNNNNNNNNNNNNNNNNKDQDSDSSQSQEDEDNNV--V-----EGEGGEGG Tor_Ddis_FRAP ----------------------------------------QRVG--V------------- TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM -------------------------------------------N--G------------- ATR_Spur_ATR -------------------------------------------K--A------------- DNAPK_Spur_DNAPK -------------------------------------------D---------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM -------------------------------------------QPKILPSRFE------- CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ----------------------------------------D--I--F------------- CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ----------------------------------------------G------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK -------------------------------------------D---------------- AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ----------------------------------------------------YR------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ----------------------------------------------F------------- DNAPK_Smoe_DNAPK -------------------------------------------H---------------- FRAP_Smoe_FRAP ----------------------------------------E--M--L------------- SMG1_Smoe_SMG1 ------------------------------------------------------------ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ----------------------------------------SQQLVSLVQKAVT------- SMG1_Hsap_SMG1 DTPPSTVPGTGKSVACSPKKAVRD-P-KTGKA-VQERNSYAVSVWKRVKAKLEGRD---- FRAP_Hsap_FRAP ------------------HSF--I-G-DGLVK-PEALNKKAIQIINRVRDKLTGRD---- mei-41_Dmel_ATR ----------------------------------------ITKDVQRIADRLQGH----- CG2905_Dmel_TRRAP ---------------------------------------CMEHSVNIVNSAVD------- CG6535_Dmel_ATM -------------------------------GE-ESVNLVAQRALLLVQNKLDGRE---- CG4549_Dmel_SMG1 ----------------YEIFTHAK-G-SGNVH-EQKRNAYGVSVWKKIRMKLEGRD---- FRAP_Mmus_FRAP ------------------HSF--I-G-DGLVK-PEALNKKAIQIINRVRDKLTGRD---- DNAPK_Mmus_DNAPK ------------------------------------KNWYPQHKIRYAKRKLAGANPAVI ATR_Mmus_ATR ----------------------------------------AKTHVLDIEQRLQGV----- ATM_Mmus_ATM -----------------------K-Q-SLSDTD-QSFNKVAERVLMRLQEKLKGVE---- C47D12.1_Cele_TRRAP -------------------------------------CHASNSYINGVASKLRNTN---- B0261.2_Cele_FRAP ---------------------------NMAGA-VLPSSSTTDSIMETIKRKLDGTE---- atm-1_Cele_ATM ------------------------------------PSYISEMAIGRLREKLRGTD---- atl-1_Cele_ATR ----------------------------------------MSEAKRLVSGRLRGQIMT-- TEL1_Scer_ATM -----------------------S-K-FISNN-DRNENQESYRALKGVEEKLMG------ MEC1_Scer_ATR --------------------------------------------LKVLRNKIRGI----- ATM_Hsap_ATM -----------------------K-R-NLSDID-QSFNKVAERVLMRLQEKLKGVE---- ATR_Hsap_ATR ----------------------------------------AKTHVLDIEQRLQGV----- DNAPK_Hsap_DNAPK ------------------------------------KNWYPRQKICYAKRKLAGANPAVI TOR_Dmel_FRAP ---------------------QQG-G-LHNNV-ADETNSKASQVIKRVKCKLTGTD---- SMG1_Mmus_SMG1 DTPPSTIPGTGKSIACSPKKAVRD-P-KTGKA-VQERNSYAVSVWKRVKAKLEGRD---- TRRAP_Mmus_TRRAP ----------------------------------------SQQLVSLVQKAVT------- smg-1_Cele_SMG1 FTPIETITSRTSQQEFKPPPGLEN-V-WVVKQ-DQQENSQAREVVRRVERRLNGWL---- TOR1_Scer_FRAP --------------------A--N-M-EAEQQ-NETKNARAMLVLRRITDKLTGND---- TOR2_Scer_FRAP --------------------Q--R-V-ENEHK-NAIRNARAMLVLKRITDKLTGND---- TRA1_Scer_TRRAP -------------------------------------------LREMVQTNVD------- ATR_Ddis_ATR ------------------------------------ENDQAVEILKRISATLQGI----- DNAPK_Ddis_DNAPK ------------------------------------NVWFPKQKIQIAKKKLELVNPAYI SMG1_Ddis_SMG1 EGD------------IDELNLVQD-S-SNG-K-DAFKSIQGLTVVNQVRLKLEGT----- Tor_Ddis_FRAP ------------------DAE--Q-V-EAEIV-PEALNERALSVINRVNKKLTGRD---- TRRAP_Ddis_TRRAP -----------------------------NIH-YEFIDKTTATVHQMLENRIDSLT---- ATMa_Spur_ATM -----------------------A-S-SPTTS-REEVNQVAERVLLRLRQKLGGVE---- ATR_Spur_ATR -------------------------R--LN-----HLKYSALVHVRDIEQRLQGI----- DNAPK_Spur_DNAPK ------------------------------------ISWYPKKKIKFAEMKLQGVNSTYI FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM -----------------------LGGLGIDMT-SGTAEEAADRALSSVARKLD------- CC1G_08126_Ccin_ATR ------------------------------------TTNIAKNALNDIKKKLEGRFTP-- CC1G_00894_Ccin_FRAP ---------------------NET-E-EEPGA-QEVRNERALFVYNRVQHKLTGRD---- CC1G_06302_Ccin_PI3K ----------------------------------------------QIQEKFRL-D---- CC1G_04234_Ccin_PI4K -------------------------------------NQLRDRFMPTLTHS--------- CC1G_13883_Ccin_PI4K -----------------------------------------EPTIRRLRDRFTLSL---- CC1G_00331_Ccin_TRRAP ------------------------------------MDNVVKK-AEAMACKLERENSQ-- AqueK043_Aque_ATM -----------------------D-T-SGAND-VSSNNKMAERVLIRLQEKLEGVE---- AqueK044_Aque_ATR --------------------------------------DKGVKIVSDIDERLQG------ AqueK045_Aque_DNAPK ------------------------------------NTWYPKEKVNICRKKLLGFNSSHL AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ----------------SSQGIVRD-L-RTGKA-LQEQNSYAVSVWRRVKGKLDGRD---- AqueK048_Aque_TRRAP ----------------------------------------SEMVTPFVNDAVD------- ATM_Smoe_ATM ----------------------------VEDPDKVEGNKDATRALMRVKQKLDGYR---- ATR_Smoe_ATR -------------------------G-LC-----IGTDWAFQRALANIEARLRGV----- DNAPK_Smoe_DNAPK ------------------------------------EQQHVELKIENAQRKLDLWNPAHV FRAP_Smoe_FRAP ------------------HAFNVV-G-QLGDA-NEVLNERAVSVMGRMSDKLTGRD---- SMG1_Smoe_SMG1 ------------------------------DL-SLSLDQVISQHKRRLEAQLQGVL---- GK008_Glam_FRAP ----------------------PV-Q-ESYLE-GNERNPKAVKIVQRIYDKLTGYD---- GK009_Glam_PIKK-Unclassified ----------------------------------------SLGYVRQVKEML-------- TRRAP_Hsap_TRRAP ------------------------A--------IM--TR--L-HNL-------------- SMG1_Hsap_SMG1 -------------------------------------------VDP-------------- FRAP_Hsap_FRAP ----------------------------------F---------SH-------------- mei-41_Dmel_ATR ---------------------------------VK---R--Q-QAN-------------- CG2905_Dmel_TRRAP ------------------------I--------IM--TR--F-NKI-------------- CG6535_Dmel_ATM -------------------------------------------AGT-------------- CG4549_Dmel_SMG1 -------------------------------------------PDS-------------- FRAP_Mmus_FRAP ----------------------------------F---------SH-------------- DNAPK_Mmus_DNAPK TCDELYLGHE-----ASSAFRSYTAVARGNRD-YN--IR--A-QEP-------------- ATR_Mmus_ATR ---------------------------------IK--TR--N-RVT-------------- ATM_Mmus_ATM -------------------------------------------E---------------- C47D12.1_Cele_TRRAP --------------------------------------------S--------------- B0261.2_Cele_FRAP ----------------------------------F--VHTDG-STP-------------- atm-1_Cele_ATM --------------------------------------------DG-------------- atl-1_Cele_ATR ------------------------A--------KL--YR--S-NPI-------------- TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR -----------------------------------------D-PQD-------------- ATM_Hsap_ATM -------------------------------------------E---------------- ATR_Hsap_ATR ---------------------------------IK--TR--N-RVT-------------- DNAPK_Hsap_DNAPK TCDELLLGHE-----KAPAFRDYVAVARGSKD-HN--IR--A-QEP-------------- TOR_Dmel_FRAP ----------------------------------F---------QT-------------- SMG1_Mmus_SMG1 -------------------------------------------VDP-------------- TRRAP_Mmus_TRRAP ------------------------A--------IM--TR--L-HNL-------------- smg-1_Cele_SMG1 ----------------------------------D--G---S-AGP-------------- TOR1_Scer_FRAP ----------------------------------I---------KR-------------- TOR2_Scer_FRAP ----------------------------------I---------RR-------------- TRA1_Scer_TRRAP ------------------------L--------II--RK--V-AQL-------------- ATR_Ddis_ATR -----------------------------------------P--TV-------------- DNAPK_Ddis_DNAPK TLEELSGSVHS----GLPYEKALSEIIKGDP-KHN--IR--A-KVN-------------- SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ----------------------------------F---------SS-------------- TRRAP_Ddis_TRRAP ----------------------------------P--S---SQPDK-------------- ATMa_Spur_ATM -------------------------------------------D---------------- ATR_Spur_ATR ---------------------------------LK--IK--N-KSR-------------- DNAPK_Spur_DNAPK TKAELEMGPHSKDAKDAPFLKALKSTCGGN-T-ES--KR--A-QSK-------------- FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR -------------------------------Y-TD--SQ--F-EQP-------------- CC1G_00894_Ccin_FRAP ----------------------------------F---------NP-------------- CC1G_06302_Ccin_PI3K -------------------------------------------L---------------- CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ----------------------------------SERQ------AA-------------- CC1G_00331_Ccin_TRRAP -----------------------------------------Q-PNV-------------- AqueK043_Aque_ATM -------------------------------------------N---------------- AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK MLIDLEHGFK-----NKPEFKYLKGILLGDSS-TN--LR--A-RVG-------------- AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 -------------------------------------------PDP-------------- AqueK048_Aque_TRRAP ------------------------I--------TL--TR--L-FNL-------------- ATM_Smoe_ATM -------------------------------------------D---------------- ATR_Smoe_ATR ---------------------------------VV--GV--A-AAP-------------- DNAPK_Smoe_DNAPK TLGELQSSVHA----GTPWMPAIEAAVLGDPVKNT--RR--R-IDR-------------- FRAP_Smoe_FRAP ----------------------------------F--P------VG-------------- SMG1_Smoe_SMG1 -------------------------------------------DLYLRERVSPAFLDIIL GK008_Glam_FRAP ----------------------------------I--K------YI-------------- GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 KEATISSFADNSDSSREGEAAKKAVKLLREYCDVHETVRAAKSAAFALKIQADEAKQSLQ GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 NAQIEIAQMEWLHETVLLPRVQFVAMPSGPYPEKSTSIRWWSRKQILDNIRNSIAAISRA GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP --------A---QFEGG-ESKVNTLV----------------------------AAANS- SMG1_Hsap_SMG1 --------N---RRMSV-AEQVDYVI----------------------------KEATN- FRAP_Hsap_FRAP --------D---DTLDV-PTQVELLI----------------------------KQATS- mei-41_Dmel_ATR --------S---IPLST-EGQVNFLI----------------------------NEATK- CG2905_Dmel_TRRAP --------S---YFDSIENKKISVLV----------------------------QSATN- CG6535_Dmel_ATM --------M---GDSNV-EAQVERLI----------------------------NEATL- CG4549_Dmel_SMG1 --------N---QRSTV-AEQVDYVI----------------------------REACN- FRAP_Mmus_FRAP --------D---DTLDV-PTQVELLI----------------------------KQATS- DNAPK_Mmus_DNAPK --------E---SGLSE-ETQVKCLV----------------------------DQATD- ATR_Mmus_ATR --------G---LPLSI-EGHVHYLI----------------------------QEATD- ATM_Mmus_ATM --------G---TVLSV-GGQVNLLI----------------------------QQAMD- C47D12.1_Cele_TRRAP --------A---DAKLR-KDDCVSLI----------------------------SRAKD- B0261.2_Cele_FRAP --------P---EPLQV-TEQLAMLT----------------------------EQATS- atm-1_Cele_ATM --------V---TAQSS-NLQIRRLL----------------------------REATS- atl-1_Cele_ATR --------S---HPMQV-SQLASSLI----------------------------ELATS- TEL1_Scer_ATM ------------NGLSV-ESSVQDLI----------------------------QQATD- MEC1_Scer_ATR --------G---LVLSV-AGQTETLI----------------------------QEATS- ATM_Hsap_ATM --------G---TVLSV-GGQVNLLI----------------------------QQAID- ATR_Hsap_ATR --------G---LPLSI-EGHVHYLI----------------------------QEATD- DNAPK_Hsap_DNAPK --------E---SGLSE-ETQVKCLM----------------------------DQATD- TOR_Dmel_FRAP --------E---KSVNE-QSQVELLI----------------------------QQATN- SMG1_Mmus_SMG1 --------N---RRMSV-AEQVDYVI----------------------------KEATN- TRRAP_Mmus_TRRAP --------A---QFDGG-ESKVNTLV----------------------------AAANS- smg-1_Cele_SMG1 --------D---RKLSP-REEADILI----------------------------AEATS- TOR1_Scer_FRAP --------F---NELDV-PEQVDKLI----------------------------QQATS- TOR2_Scer_FRAP --------F---NDLDV-PEQVDKLI----------------------------QQATS- TRA1_Scer_TRRAP --------GHLNSTPTVTTQFILDCI----------------------------GSAVS- ATR_Ddis_ATR --------G---LQLSI-EGQVNHLI----------------------------QEATN- DNAPK_Ddis_DNAPK --------K---VCSSV-KEQIDCLI----------------------------DQSTD- SMG1_Ddis_SMG1 --------E---KKLSI-PDQIDLII----------------------------RESMN- Tor_Ddis_FRAP --------N---ETLDV-PEQVQKLI----------------------------DQATS- TRRAP_Ddis_TRRAP --------T--CFISPI-VKKVNQLI----------------------------QNSLS- ATMa_Spur_ATM --------G---VTLSV-AGQVSLLI----------------------------QEARD- ATR_Spur_ATR --------T---LPLSI-EGHVDHLI----------------------------REATD- DNAPK_Spur_DNAPK --------S---KGLSV-EDQVACLI----------------------------DQATD- FRAP_Spur_FRAP ------------------ARTCSSLL----------------------------QPAVN- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------KSLSV-ESTVNELI----------------------------AIATD- CC1G_08126_Ccin_ATR --------E---KLLST-KNLVEALI----------------------------NEASN- CC1G_00894_Ccin_FRAP --------T---QVLSV-KAQVEKLI----------------------------EQATS- CC1G_06302_Ccin_PI3K ------------SEEDA-IKHFETLL----------------------------NETSY- CC1G_04234_Ccin_PI4K ---------------LV-GEHVERLI----------------------------ASSLGS CC1G_13883_Ccin_PI4K --------D---YMMGV-IRNAHENV-----------------------------RSTA- CC1G_00331_Ccin_TRRAP --------V---PNNVV-YQTVINQI----------------------------STATN- AqueK043_Aque_ATM --------G---VQLSV-GGQVTHLI----------------------------QEARD- AqueK044_Aque_ATR ------------K------TGKTLPL----------------------------SEATD- AqueK045_Aque_DNAPK --------K---RCDSV-EDQVDCLI----------------------------DHATD- AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 --------A---CRMTV-AEQVKFVI----------------------------DEATS- AqueK048_Aque_TRRAP --------A---DFETG-KSQVSTLI----------------------------SAASN- ATM_Smoe_ATM --------G---ENRTV-EGQVQQLV----------------------------QDAQD- ATR_Smoe_ATR --------S---LPLSV-EGQAHRLI----------------------------QEAVS- DNAPK_Smoe_DNAPK --------K---ICASV-EEQVDCLV----------------------------DQATD- FRAP_Smoe_FRAP --------E---SVLSV-KDQVQKLI----------------------------DQATS- SMG1_Smoe_SMG1 TEGLQKAER---ASVSA-EEQLERTMAWASNRAGTSQEFRERLQRRQQLLWTGQEHATS- GK008_Glam_FRAP --------D---RSLSV-SEQIQSLI----------------------------HSATN- GK009_Glam_PIKK-Unclassified ------------ETQRA-EEIVNAAL----------------------------AQAAD- TRRAP_Hsap_TRRAP -----LDN---------------------------------------------------- SMG1_Hsap_SMG1 -----LDN---------------------------------------------------- FRAP_Hsap_FRAP -----HEN---------------------------------------------------- mei-41_Dmel_ATR -----VDN---------------------------------------------------- CG2905_Dmel_TRRAP -----IDN---------------------------------------------------- CG6535_Dmel_ATM -----PSN---------------------------------------------------- CG4549_Dmel_SMG1 -----PEN---------------------------------------------------- FRAP_Mmus_FRAP -----HEN---------------------------------------------------- DNAPK_Mmus_DNAPK -----PNI---------------------------------------------------- ATR_Mmus_ATR -----ENL---------------------------------------------------- ATM_Mmus_ATM -----PKN---------------------------------------------------- C47D12.1_Cele_TRRAP -----SDN---------------------------------------------------- B0261.2_Cele_FRAP -----PLN---------------------------------------------------- atm-1_Cele_ATM -----ADN---------------------------------------------------- atl-1_Cele_ATR -----EEK---------------------------------------------------- TEL1_Scer_ATM -----PSN---------------------------------------------------- MEC1_Scer_ATR -----EDN---------------------------------------------------- ATM_Hsap_ATM -----PKN---------------------------------------------------- ATR_Hsap_ATR -----ENL---------------------------------------------------- DNAPK_Hsap_DNAPK -----PNI---------------------------------------------------- TOR_Dmel_FRAP -----NEN---------------------------------------------------- SMG1_Mmus_SMG1 -----LDN---------------------------------------------------- TRRAP_Mmus_TRRAP -----LDN---------------------------------------------------- smg-1_Cele_SMG1 -----TPN---------------------------------------------------- TOR1_Scer_FRAP -----IER---------------------------------------------------- TOR2_Scer_FRAP -----VEN---------------------------------------------------- TRA1_Scer_TRRAP -----PRN---------------------------------------------------- ATR_Ddis_ATR -----PKH---------------------------------------------------- DNAPK_Ddis_DNAPK -----PNI---------------------------------------------------- SMG1_Ddis_SMG1 -----VEN---------------------------------------------------- Tor_Ddis_FRAP -----HEN---------------------------------------------------- TRRAP_Ddis_TRRAP ------SN---------------------------------------------------- ATMa_Spur_ATM -----PKN---------------------------------------------------- ATR_Spur_ATR -----KKN---------------------------------------------------- DNAPK_Spur_DNAPK -----PRI---------------------------------------------------- FRAP_Spur_FRAP -----VSF---------------------------------------------------- SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM -----PTN---------------------------------------------------- CC1G_08126_Ccin_ATR -----PMN---------------------------------------------------- CC1G_00894_Ccin_FRAP -----LEN---------------------------------------------------- CC1G_06302_Ccin_PI3K -----FTVV--------------------------------------------------- CC1G_04234_Ccin_PI4K HWTRLYDS---------------------------------------------------- CC1G_13883_Ccin_PI4K -----YDE---------------------------------------------------- CC1G_00331_Ccin_TRRAP -----PIS---------------------------------------------------- AqueK043_Aque_ATM -----SVN---------------------------------------------------- AqueK044_Aque_ATR -----IDN---------------------------------------------------- AqueK045_Aque_DNAPK -----SNV---------------------------------------------------- AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 -----PEN---------------------------------------------------- AqueK048_Aque_TRRAP -----LDN---------------------------------------------------- ATM_Smoe_ATM -----PEN---------------------------------------------------- ATR_Smoe_ATR -----HEN---------------------------------------------------- DNAPK_Smoe_DNAPK -----PNL---------------------------------------------------- FRAP_Smoe_FRAP -----SEN---------------------------------------------------- SMG1_Smoe_SMG1 -----TVRLCVTVLEFEASREGYLESSSSSSSSDGKSWQQSYQSLILRLEAAYIAFTSCD GK008_Glam_FRAP -----AEN---------------------------------------------------- GK009_Glam_PIKK-Unclassified -----SSR---------------------------------------------------- TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 MEWKAAQKALEAASANLSGVLRERQLVSSESESSGDHCAAELQSIFLQLRQLTLEAAGAV GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 NAFCKVVRSHSALTSEGAVMLDEARADGVSDVHSLAKEAITERQSLISDLKKVHAAVAPL GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP ------------------------------------------------------------ SMG1_Hsap_SMG1 ------------------------------------------------------------ FRAP_Hsap_FRAP ------------------------------------------------------------ mei-41_Dmel_ATR ------------------------------------------------------------ CG2905_Dmel_TRRAP ------------------------------------------------------------ CG6535_Dmel_ATM ------------------------------------------------------------ CG4549_Dmel_SMG1 ------------------------------------------------------------ FRAP_Mmus_FRAP ------------------------------------------------------------ DNAPK_Mmus_DNAPK ------------------------------------------------------------ ATR_Mmus_ATR ------------------------------------------------------------ ATM_Mmus_ATM ------------------------------------------------------------ C47D12.1_Cele_TRRAP ------------------------------------------------------------ B0261.2_Cele_FRAP ------------------------------------------------------------ atm-1_Cele_ATM ------------------------------------------------------------ atl-1_Cele_ATR ------------------------------------------------------------ TEL1_Scer_ATM ------------------------------------------------------------ MEC1_Scer_ATR ------------------------------------------------------------ ATM_Hsap_ATM ------------------------------------------------------------ ATR_Hsap_ATR ------------------------------------------------------------ DNAPK_Hsap_DNAPK ------------------------------------------------------------ TOR_Dmel_FRAP ------------------------------------------------------------ SMG1_Mmus_SMG1 ------------------------------------------------------------ TRRAP_Mmus_TRRAP ------------------------------------------------------------ smg-1_Cele_SMG1 ------------------------------------------------------------ TOR1_Scer_FRAP ------------------------------------------------------------ TOR2_Scer_FRAP ------------------------------------------------------------ TRA1_Scer_TRRAP ------------------------------------------------------------ ATR_Ddis_ATR ------------------------------------------------------------ DNAPK_Ddis_DNAPK ------------------------------------------------------------ SMG1_Ddis_SMG1 ------------------------------------------------------------ Tor_Ddis_FRAP ------------------------------------------------------------ TRRAP_Ddis_TRRAP ------------------------------------------------------------ ATMa_Spur_ATM ------------------------------------------------------------ ATR_Spur_ATR ------------------------------------------------------------ DNAPK_Spur_DNAPK ------------------------------------------------------------ FRAP_Spur_FRAP ------------------------------------------------------------ SMG1_Spur_SMG1 ------------------------------------------------------------ TRRAP_Spur_TRRAP ------------------------------------------------------------ CC1G_00839_Ccin_ATM ------------------------------------------------------------ CC1G_08126_Ccin_ATR ------------------------------------------------------------ CC1G_00894_Ccin_FRAP ------------------------------------------------------------ CC1G_06302_Ccin_PI3K ------------------------------------------------------------ CC1G_04234_Ccin_PI4K ------------------------------------------------------------ CC1G_13883_Ccin_PI4K ------------------------------------------------------------ CC1G_00331_Ccin_TRRAP ------------------------------------------------------------ AqueK043_Aque_ATM ------------------------------------------------------------ AqueK044_Aque_ATR ------------------------------------------------------------ AqueK045_Aque_DNAPK ------------------------------------------------------------ AqueK046_Aque_FRAP ------------------------------------------------------------ AqueK047_Aque_SMG1 ------------------------------------------------------------ AqueK048_Aque_TRRAP ------------------------------------------------------------ ATM_Smoe_ATM ------------------------------------------------------------ ATR_Smoe_ATR ------------------------------------------------------------ DNAPK_Smoe_DNAPK ------------------------------------------------------------ FRAP_Smoe_FRAP ------------------------------------------------------------ SMG1_Smoe_SMG1 ELLLSSTANAMSADLDVKAVIKSGQSPTLQSLDLKIKESLADLPLHVSSVLDAAQKLHSA GK008_Glam_FRAP ------------------------------------------------------------ GK009_Glam_PIKK-Unclassified ------------------------------------------------------------ TRRAP_Hsap_TRRAP -----------LCRMDPAWH---------------------------PWL SMG1_Hsap_SMG1 -----------LAQLYEGWT---------------------------AWV FRAP_Hsap_FRAP -----------LCQCYIGWC---------------------------PFW mei-41_Dmel_ATR -----------LASMYIGWG---------------------------AFL CG2905_Dmel_TRRAP -----------LCRMDPAWH---------------------------PWL CG6535_Dmel_ATM -----------LCMLFPGWD---------------------------PHL CG4549_Dmel_SMG1 -----------LAVLYEGWT---------------------------PWV FRAP_Mmus_FRAP -----------LCQCYIGWC---------------------------PFW DNAPK_Mmus_DNAPK -----------LGRTWEGWE---------------------------PWM ATR_Mmus_ATR -----------LCQMYLGWT---------------------------PYM ATM_Mmus_ATM -----------LSRLFPGWK---------------------------AWV C47D12.1_Cele_TRRAP -----------LARMPPTYH---------------------------AWF B0261.2_Cele_FRAP -----------LCQSYIGWC---------------------------PFW atm-1_Cele_ATM -----------LSRMFCGWM---------------------------PFL atl-1_Cele_ATR -----------LSEMYLGWM---------------------------ATL TEL1_Scer_ATM -----------LSVIYMGWS---------------------------PFY MEC1_Scer_ATR -----------LSKMYIGWL---------------------------PFW ATM_Hsap_ATM -----------LSRLFPGWK---------------------------AWV ATR_Hsap_ATR -----------LCQMYLGWT---------------------------PYM DNAPK_Hsap_DNAPK -----------LGRTWEGWE---------------------------PWM TOR_Dmel_FRAP -----------LCQCYIGWC---------------------------PFW SMG1_Mmus_SMG1 -----------LAQLYEGWT---------------------------AWV TRRAP_Mmus_TRRAP -----------LCRMDPAWH---------------------------PWL smg-1_Cele_SMG1 -----------LSQMYEGWT---------------------------AWV TOR1_Scer_FRAP -----------LCQHYIGWC---------------------------PFW TOR2_Scer_FRAP -----------LCQHYIGWC---------------------------PFW TRA1_Scer_TRRAP -----------LARTDVNFM---------------------------PWF ATR_Ddis_ATR -----------LCNMYVGWC---------------------------SWY DNAPK_Ddis_DNAPK -----------LSRAWVGWN---------------------------GAL SMG1_Ddis_SMG1 -----------LSSTYEGWS---------------------------PWV Tor_Ddis_FRAP -----------LCLSYVGWC---------------------------PFW TRRAP_Ddis_TRRAP -----------ISQLDQLSC---------------------------PWL ATMa_Spur_ATM -----------LSRLYPGWS---------------------------PWL ATR_Spur_ATR -----------LCLMYIGWA---------------------------AYM DNAPK_Spur_DNAPK -----------LGKTYQGWE---------------------------PWV FRAP_Spur_FRAP -----------HG--VIVHY---------------------------VVF SMG1_Spur_SMG1 -------------------------------------------------E TRRAP_Spur_TRRAP -----------------RAA---------------------------RVK CC1G_00839_Ccin_ATM -----------LGKIFYGWA---------------------------PHM CC1G_08126_Ccin_ATR -----------LSKMYPGWA---------------------------PWN CC1G_00894_Ccin_FRAP -----------LCQCFSGWC---------------------------AFW CC1G_06302_Ccin_PI3K -----------LDRIHDLAQ----------------------Y----WRS CC1G_04234_Ccin_PI4K -----------VRVLKITWCPTSLTGTLASSNTTHNPSYNDYSYIPHGQA CC1G_13883_Ccin_PI4K -----------FQRLQ-NGI---------------------------PYK CC1G_00331_Ccin_TRRAP -----------LAKMGELYQ---------------------------PWF AqueK043_Aque_ATM -----------LSSLFHGWQ---------------------------PWI AqueK044_Aque_ATR -----------LCQMYIGWG---------------------------PYL AqueK045_Aque_DNAPK -----------LGRTYGGWE---------------------------AWV AqueK046_Aque_FRAP --------------VSLFLL---------------------------CLY AqueK047_Aque_SMG1 -----------LCQLYEGWT---------------------------PWV AqueK048_Aque_TRRAP -----------ICRMDPAWN---------------------------PWL ATM_Smoe_ATM -----------LCLLFPGWA---------------------------AWL ATR_Smoe_ATR -----------LGHMYVWWM---------------------------PWF DNAPK_Smoe_DNAPK -----------LGRLWVGWQ---------------------------PWM FRAP_Smoe_FRAP -----------LCQSYVGWC---------------------------PFW SMG1_Smoe_SMG1 LTSLGRTASVDAGTLNKASP---------------------------NVS GK008_Glam_FRAP -----------LCQLYIGWC---------------------------PYW GK009_Glam_PIKK-Unclassified -----------LSCMFGGWM---------------------------AFL