CLUSTAL W (1.83) multiple sequence alignment PRKY_Hsap MEAPGPA------------------------------QA--------------------- PRKX_Hsap MEAPGLA------------------------------QA--------------------- PKACg_Hsap MGNAPAK------------------------------KDT-----------E-------- PKACb_Hsap MAAYREP------------------------------PCN-----------QYTGTT-T- PKACa_Hsap MGNAAAA------------------------------KKG-----------S-------- Pka-C1_Dmel MGNNATT------------------------------SNK-----------K-------- Pka-C2_Dmel MSQHTSQ------------------------------YVF-------------------- CG12069_Dmel MGPQPEQ------------------------------AQM-----------HF------- PKA-C3_Dmel MSTATCA------------------------------RFCTPL---SS---G-T------ PRKX_Mmus MEPPAGA------------------------------AA--------------------- PKACb_Mmus MAAHKEL------------------------------SSG-----------QHSGTP-T- PKACa_Mmus MGNAAAA------------------------------KKG-----------S-------- kin-1_Cele MLKFLKP------------------------------KSS-----------DEG------ F47F2.1_Cele MVILSHH------------------------------KRS-----------PP-L-LMRL TPK1_Scer MSTEEQN------------------------------GGG-----------QKSL----- TPK2_Scer MEFVAER------------------------------AQP-----------VGQT----- TPK3_Scer MYVDPMN------------------------------NNE-----------IRKL----- DDB0185224_Ddis MSAILNN------------------------------YQY-----------IPNN-SL-- pk4_Ddis QQQQQQQ------------------------------QQQ-----------QQQQ-QQ-- PKA_Ddis MSNSNNN------------------------------SSS-----------G-N------ 17649_Tthe MQISEEQ------------------------------FF------------E-QF----- 18333_Tthe MNWEELV------------------------------YKLSYLKIERDNQIE-NL----- 2171_Tthe MEGFKAK------------------------------QVK-----------LTEFDVMNT 26485_Tthe MEKAKKM--------------------------------K-------------------- PRKX_Spur ------------------------------------------------------------ PKA_Spur ------------------------------------------------------------ CC1G_05183_Ccin MSFQHHP------------------------------TSL-----------SMPA----- CC1G_04466_Ccin MIKRMAG------------------------------KLT-----------AHIGGHHNG CC1G_01089_Ccin MGPVRAN------------------------------KST-----------REAR----- AqueK013_Aque MALFFPCDVDCEDVFCDCLFKRTEPAHIVRYELQPRPAAT---------TVSHSETQ-P- AqueK014_Aque MGGHLRK------------------------------DQS-----------KAK-KP-P- AqueK015_Aque MTDLTHE------------------------------EEE-----------E-------- PKA-1_Smoe ------------------------------------------------------------ PKA-2_Smoe ------------------------------------------------------------ GK005_Glam MEDIQVE----------------------------------------------------- GK006_Glam MGQNQSG------------------------------VAG-----------NA------- PRKY_Hsap ------------------------------------------------------------ PRKX_Hsap ------------------------------------------------------------ PKACg_Hsap ------------------------------------------------------------ PKACb_Hsap --------------ALQK----------------LE------------------------ PKACa_Hsap ------------------------------------------------------------ Pka-C1_Dmel ------------------------------------------------------------ Pka-C2_Dmel ------------------------------------------------------------ CG12069_Dmel ------------------------------------------------------------ PKA-C3_Dmel --------------------A----------------------GSTSKLTTGNGSGNTMT PRKX_Mmus ------------------------------------------------------------ PKACb_Mmus --------------ALQK----------------LE------------------------ PKACa_Mmus ------------------------------------------------------------ kin-1_Cele ------------------------------------------------------------ F47F2.1_Cele ----F---RICRFF---------------------------------------------- TPK1_Scer ------------------------------------------------------------ TPK2_Scer ------------------------------------------------------------ TPK3_Scer ------------------------------------------------------------ DDB0185224_Ddis ------------------------------------------------------------ pk4_Ddis ------------------------------------------------------------ PKA_Ddis --------------------HNSTTIN----NPKVNVYSNIPNS--TTYTYGSGGGGTLS 17649_Tthe ------------------------------------------------------------ 18333_Tthe -------------SLNQKIAENQTKIKNDIFQDSINPFNY-------------------- 2171_Tthe ---LGTVCQIVLFN---------------------------------------------- 26485_Tthe ------------------------------------------------------------ PRKX_Spur ------------------------------------------------------------ PKA_Spur ------------------------------------------------------------ CC1G_05183_Ccin ------------------------------------------------------------ CC1G_04466_Ccin KGFLG------------------------------------------------------- CC1G_01089_Ccin ------------------------------------------------------------ AqueK013_Aque -------------LSVPR------------------------------------------ AqueK014_Aque ------------------------------------------------------------ AqueK015_Aque ------------------------------------------------------------ PKA-1_Smoe ------------------------------------------------------------ PKA-2_Smoe ------------------------------------------------------------ GK005_Glam ------------------------------------------------------------ GK006_Glam ------------------------------------------------------------ PRKY_Hsap ------------------------------------------AA---------------A PRKX_Hsap ------------------------------------------AA---------------A PKACg_Hsap ------------------------------------------------------------ PKACb_Hsap -------------------------------------------------G---------- PKACa_Hsap ------------------------------------------------------------ Pka-C1_Dmel ------------------------------------------------------------ Pka-C2_Dmel ------------------------------------------------------------ CG12069_Dmel ------------------------------------------------------------ PKA-C3_Dmel SAYKIPSNN---------ST----------------------TA---------------N PRKX_Mmus ------------------------------------------TV---------------K PKACb_Mmus -------------------------------------------------G---------- PKACa_Mmus ------------------------------------------------------------ kin-1_Cele ------------------------------------------------------------ F47F2.1_Cele --------R---------RLM--SS---------------STSS---------------V TPK1_Scer ------------------------D---------------DRQG---------------E TPK2_Scer ------------------------I---------------QQQN---------------V TPK3_Scer ------------------------S---------------ITAK---------------T DDB0185224_Ddis ------------------------N---------------S-NN---------------S pk4_Ddis ------------------------QH--------------Q-KT---------------S PKA_Ddis GN--NTNNNNTNNNNNNNNN----------------------SS---------------G 17649_Tthe ------------------------------------------------------------ 18333_Tthe ---IVPFEK---------ES----------------------SS---------------S 2171_Tthe --------L----------NL--SD---------------VQSS-DRYIPFRIGTAFVQK 26485_Tthe ------------------------------------------------------------ PRKX_Spur ------------------------------------------------------------ PKA_Spur ------------------------------------------------------------ CC1G_05183_Ccin ------------------------EPVRRISITYQQPSCPESQVVV-------------T CC1G_04466_Ccin --------------------ATGLT---------------PSSP---------------S CC1G_01089_Ccin ------------------------------------------NH---------------V AqueK013_Aque -------------------------------------------------P---------- AqueK014_Aque ------------------------------------------------------------ AqueK015_Aque ------------------------------------------------------------ PKA-1_Smoe ------------------------------------------------------------ PKA-2_Smoe ------------------------------------------------------------ GK005_Glam ------------------------------------------------------------ GK006_Glam ------------------------------------------------------------ PRKY_Hsap E----------------------------------------------------------- PRKX_Hsap E----------------------------------------------------------- PKACg_Hsap ------------------------------------------------------------ PKACb_Hsap -------------------------------FASRLF----------------------- PKACa_Hsap ------------------------------------------------------------ Pka-C1_Dmel ------------------------------------------------------------ Pka-C2_Dmel ------------------------------------------------------------ CG12069_Dmel ------------------------------------------------------------ PKA-C3_Dmel D---------------SS---NTETTFTF------------------------------- PRKX_Mmus D----------------------------------------------------------- PKACb_Mmus -------------------------------FASRLF----------------------- PKACa_Mmus ------------------------------------------------------------ kin-1_Cele ------------------------------------------------------------ F47F2.1_Cele E------------SV--E---D-------------------------------------- TPK1_Scer E------------SQ--K---GETS-E--------------------------------- TPK2_Scer N------------T---------YG-QGVLQ------P---------------------- TPK3_Scer E------------TT--P---DNVG-QDIPV------N---------------------- DDB0185224_Ddis N------------------NGNNSTILSLCDNATQL------------------------ pk4_Ddis PSTSFVDYNNINNSNGNNINGTTSTCN--------------------------------- PKA_Ddis D---------------NK---NHSPVTSATD------RLTKMDIEEKWDNKNYEKDEREK 17649_Tthe ------------------------QIKLI--------QL--------------------- 18333_Tthe E-----------------------NIDFL--------DA--------------------- 2171_Tthe A------------SFYIK---N-------------------------------------- 26485_Tthe ------------------------------------------------------------ PRKX_Spur ------------------------------------------------------------ PKA_Spur ------------------------------------------------------------ CC1G_05183_Ccin E--APITPPLSPKSI--ATKSGAMPVEEMPICSSKPIQI--------------------- CC1G_04466_Ccin E------------AM-YP---DTTTLPTIPM------AV--------------------- CC1G_01089_Ccin E----------------------------------------------------------- AqueK013_Aque -------------------------------TPSRQI----------------------- AqueK014_Aque ------------------------------------------------------------ AqueK015_Aque E------------RM--Q---H-------------------------------------- PKA-1_Smoe ------------------------------------------------------------ PKA-2_Smoe ------------------------------------------------------------ GK005_Glam ------------------------------------------------------------ GK006_Glam ------------------------------------------------------------ PRKY_Hsap ------------------------------------------------------------ PRKX_Hsap ------------------------------------------------------------ PKACg_Hsap ------------------------------------------------------------ PKACb_Hsap -------HRH-----------------------------------------------SKG PKACa_Hsap ------------------------------------------------------------ Pka-C1_Dmel ------------------------------------------------------------ Pka-C2_Dmel ------------------------------------------------------------ CG12069_Dmel ------------------------------------------------------------ PKA-C3_Dmel -KLGRSNGRSSSNV---------------------ASS---------------------- PRKX_Mmus ------------------------------------------------------------ PKACb_Mmus -------HRH-----------------------------------------------SRG PKACa_Mmus ------------------------------------------------------------ kin-1_Cele ------------------------------------------------------------ F47F2.1_Cele ------------------------------------------------------------ TPK1_Scer --------------------------------------------------------R--- TPK2_Scer --------------------------------------------------------H--- TPK3_Scer --------------------------------------------------------A--- DDB0185224_Ddis --------------------------------------------------------M--- pk4_Ddis ------------------------------------------------------------ PKA_Ddis SP---LFHILASNLNSFGNFKVPSTFSLTPPEPNKQQQPQQQPQQQQPQQQQPQQQQ--- 17649_Tthe -----------------------------------AKI----------------KQR--- 18333_Tthe -----------------------------------QQN----------------EQD--- 2171_Tthe ------------------------------------------------------------ 26485_Tthe ------------------------------------------------------------ PRKX_Spur ------------------------------------------------------------ PKA_Spur ------------------------------------------------------------ CC1G_05183_Ccin --------------------------------------------------------HSEQ CC1G_04466_Ccin -----------------------------------SSL----------------EHR--- CC1G_01089_Ccin ------------------------------------------------------------ AqueK013_Aque -------QQD-----------------------------------------------DNN AqueK014_Aque ------------------------------------------------------------ AqueK015_Aque ------------------------------------------------------------ PKA-1_Smoe ------------------------------------------------------------ PKA-2_Smoe ------------------------------------------------------------ GK005_Glam ------------------------------------------------------------ GK006_Glam ------------------------------------------------------------ PRKY_Hsap -----------------------------S------------------------------ PRKX_Hsap -----------------------------S------------------------------ PKACg_Hsap ------------------------------------------------------------ PKACb_Hsap T-----------AHDQ-------------K-------TAL----E--------------- PKACa_Hsap ------------------------------------------------------------ Pka-C1_Dmel ------------------------------------------------------------ Pka-C2_Dmel ------------------------------------------------------------ CG12069_Dmel ------------------------------------------------------------ PKA-C3_Dmel -----------------------------E------------------------------ PRKX_Mmus -----------------------------P------------------------------ PKACb_Mmus T-----------AQEH-------------R-------AAL----E--------------- PKACa_Mmus ------------------------------------------------------------ kin-1_Cele -------------------------------------SSK----D--------------- F47F2.1_Cele --------------E--------------S-------CSN----E--CSA---------- TPK1_Scer --------------E--------------T-------TAT----E--SGN---------- TPK2_Scer --------------H--------------------------------------------- TPK3_Scer --------------H--------------S-------VHE----E--C-S---------- DDB0185224_Ddis --------------DIIMREFNEPIFDYNQ-------NSS----EINK------------ pk4_Ddis -----------------------------S-------TSS----S-KS------------ PKA_Ddis -----------------------------P-------------------QQQQ------- 17649_Tthe -----------------------------E-------------------EQQ-------- 18333_Tthe -----------------------------S-------------------DEDDYQYDEDE 2171_Tthe --------------K--------------E-------IYS--------AS---------- 26485_Tthe ------------------------------------------------------------ PRKX_Spur ------------------------------------------------------------ PKA_Spur ------------------------------------------------------------ CC1G_05183_Ccin --------------E--------------A-------MDV----E--SAP---------- CC1G_04466_Ccin --------------D--------------S-------IST----E--RTS---------- CC1G_01089_Ccin -----------------------------AGPTQRSPP---------------------- AqueK013_Aque NNNDNNEDCSRTSHES-------------R-------QNIDRFDE--------------- AqueK014_Aque -------------LN--------------S-------SAM----G--------------- AqueK015_Aque --------------Q--------------T-------VLP-------AQT---------- PKA-1_Smoe ------------------------------------------------------------ PKA-2_Smoe ------------------------------------------------------------ GK005_Glam ------------------------------------------------------------ GK006_Glam ------------------------------------------------------------ PRKY_Hsap ------------------------------------N-SR---------E---------- PRKX_Hsap ------------------------------------D-SR---------K---------- PKACg_Hsap ------------------------------------------------------------ PKACb_Hsap -N------------------DS--LHFSE------------------------------- PKACa_Hsap ------------------------------------------------------------ Pka-C1_Dmel ------------------------------------------------------------ Pka-C2_Dmel ------------------------------------------------------------ CG12069_Dmel ------------------------------------------------------------ PKA-C3_Dmel ------------------------------------S-SD---------P---------- PRKX_Mmus ------------------------------------D-HD---------P---------- PKACb_Mmus -D------------------DG--LRASE------------------------------- PKACa_Mmus ------------------------------------------------------------ kin-1_Cele ------------------------------------------------------------ F47F2.1_Cele --------------------------------------SF---------T---------- TPK1_Scer ------------------------------------E-SK---------S---------- TPK2_Scer -------------------------------------------------D---------- TPK3_Scer ------------------------------------S-NT---------P---------- DDB0185224_Ddis ------------------------------------SLVK---------TIKS------- pk4_Ddis ------------------------------------NSKE---------IYNENNNNNNN PKA_Ddis ---QQQPQQQQQPQ--------QQLQQNNQQQQQQLQ-QQ---------Q---------- 17649_Tthe ---NRNGD------------------------I--QQ-SE---------P---------- 18333_Tthe EDEDDNGEENEQYFNQIKMNENAILN-NNQNAQ--NQ-KMNKIQFQCFED---------- 2171_Tthe --------------------------------------SY---------L---------- 26485_Tthe ------------------------------------------------------------ PRKX_Spur ------------------------------------------------------------ PKA_Spur ------------------------------------------------------------ CC1G_05183_Ccin ------------------------------------V-HQ---------H---------- CC1G_04466_Ccin ---------------------------------------T-------------------- CC1G_01089_Ccin --------------------------------------QA---------PY--------- AqueK013_Aque -D----------LSLALYLSSQ--VETNS------------------------------- AqueK014_Aque ------------------------------------------------------------ AqueK015_Aque --------------------------------------ST---------T---------- PKA-1_Smoe ------------------------------------------------------------ PKA-2_Smoe ------------------------------------------------------------ GK005_Glam ------------------------------------------------------------ GK006_Glam ------------------------------------------------------------ PRKY_Hsap ------------------------------------------------------------ PRKX_Hsap ------------------------------------------------------------ PKACg_Hsap ------------------------------------------------------------ PKACb_Hsap ------------------------------------------------------------ PKACa_Hsap ------------------------------------------------------------ Pka-C1_Dmel ------------------------------------------------------------ Pka-C2_Dmel ------------------------------------------------------------ CG12069_Dmel ------------------------------------------------------------ PKA-C3_Dmel ------------------------------------------------------------ PRKX_Mmus ------------------------------------------------------------ PKACb_Mmus ------------------------------------------------------------ PKACa_Mmus ------------------------------------------------------------ kin-1_Cele ------------------------------------------------------------ F47F2.1_Cele --------------------------FD-------------------------------- TPK1_Scer --------------------------VE-------------------------------- TPK2_Scer --------------------------LQ-------------------------------- TPK3_Scer --------------------------VE-------------------------------- DDB0185224_Ddis -------------------------LLETLTKNLNNINNNIN-----------------N pk4_Ddis NNNNSFTNVHNNNNNNNNNRKRRNSHISYDTPDSNNIDNNIESNDTESGFRKNSKKSTDN PKA_Ddis ------------------------------------------------------------ 17649_Tthe ------------------------------------------------------------ 18333_Tthe ------------------------------------------------------------ 2171_Tthe --------------------------ID-------------------------------- 26485_Tthe ------------------------------------------------------------ PRKX_Spur ------------------------------------------------------------ PKA_Spur ------------------------------------------------------------ CC1G_05183_Ccin --------------------------PN-------------------------------- CC1G_04466_Ccin ------------------------------------------------------------ CC1G_01089_Ccin ------------------------------------------------------------ AqueK013_Aque ------------------------------------------------------------ AqueK014_Aque ------------------------------------------------------------ AqueK015_Aque --------------------------TD-------------------------------- PKA-1_Smoe ------------------------------------------------------------ PKA-2_Smoe ------------------------------------------------------------ GK005_Glam ------------------------------------------------------------ GK006_Glam ------------------------------------------------------------ PRKY_Hsap ------------------------------------------------------------ PRKX_Hsap ------------------------------------------------------------ PKACg_Hsap ------------------------------------------------------------ PKACb_Hsap -------------H---------------------------------------------- PKACa_Hsap ------------------------------------------------------------ Pka-C1_Dmel ------------------------------------------------------------ Pka-C2_Dmel ------------------------------------------------------------ CG12069_Dmel ------------------------------------------------------------ PKA-C3_Dmel ------------------------------------------------------------ PRKX_Mmus ------------------------------------------------------------ PKACb_Mmus -------------H---------------------------------------------- PKACa_Mmus ------------------------------------------------------------ kin-1_Cele ------------------------------------------------------------ F47F2.1_Cele ---------TN---N--------------------------------------------- TPK1_Scer ---------KE-GGE--------------------------------------------- TPK2_Scer ---------QR---Q--------------------------------------------- TPK3_Scer ---------IN-GRN--------------------------------------------- DDB0185224_Ddis NISNNNNNNNN----NNNNN-NNNNNNNN---------------NINNNNNFNTPQIIIN pk4_Ddis ----NNNNNNNNNNNNNNNNNNNNNNNNNNSCNINGNINNGNSNNINNNNCSNID----- PKA_Ddis ------------------------------------------------------------ 17649_Tthe ------------------------------------------------------------ 18333_Tthe ------------------------------------------------------------ 2171_Tthe ---------SL---Y--------------------------------------------- 26485_Tthe ------------------------------------------------------------ PRKX_Spur ------------------------------------------------------------ PKA_Spur ------------------------------------------------------------ CC1G_05183_Ccin ---------TMPGEQ--------------------------------------------- CC1G_04466_Ccin --------------S--------------------------------------------- CC1G_01089_Ccin ------------------------------------------------------------ AqueK013_Aque -------------N---------------------------------------------- AqueK014_Aque -------------N---------------------------------------------- AqueK015_Aque ---------SV---A--------------------------------------------- PKA-1_Smoe ------------------------------------------------------------ PKA-2_Smoe ------------------------------------------------------------ GK005_Glam ------------------------------------------------------------ GK006_Glam ------------------------------------------------------------ PRKY_Hsap ------------------------------------------------------------ PRKX_Hsap ------------------------------------------------------------ PKACg_Hsap ------------------------------------------------------------ PKACb_Hsap ------------------------------------------------------------ PKACa_Hsap ------------------------------------------------------------ Pka-C1_Dmel ------------------------------------------------------------ Pka-C2_Dmel ------------------------------------------------------------ CG12069_Dmel ------------------------------------------------------------ PKA-C3_Dmel ------------------------------------------------------------ PRKX_Mmus ------------------------------------------------------------ PKACb_Mmus ------------------------------------------------------------ PKACa_Mmus ------------------------------------------------------------ kin-1_Cele ------------------------------------------------------------ F47F2.1_Cele ------------------------------------------------------------ TPK1_Scer ------------------------------------------------------------ TPK2_Scer ------------------------------------------------------------ TPK3_Scer ------------------------------------------------------------ DDB0185224_Ddis DNYKLYTPPPAPMLKGLSCEVPFETMEYMQPLDLSNNNISLNNSCNMI------------ pk4_Ddis --------------------------------------------STLADVSKHQYTNQHQ PKA_Ddis ------------------------------------------------------------ 17649_Tthe ------------------------------------------------------------ 18333_Tthe ------------------------------------------------------------ 2171_Tthe ------------------------------------------------------------ 26485_Tthe ------------------------------------------------------------ PRKX_Spur ------------------------------------------------------------ PKA_Spur ------------------------------------------------------------ CC1G_05183_Ccin ------------------------------------------------------------ CC1G_04466_Ccin ------------------------------------------------------------ CC1G_01089_Ccin ------------------------------------------------------------ AqueK013_Aque ------------------------------------------------------------ AqueK014_Aque ------------------------------------------------------------ AqueK015_Aque ------------------------------------------------------------ PKA-1_Smoe ------------------------------------------------------------ PKA-2_Smoe ------------------------------------------------------------ GK005_Glam ------------------------------------------------------------ GK006_Glam ------------------------------------------------------------ PRKY_Hsap -----------------------VT---E-D-----AA---------DW----------- PRKX_Hsap -----------------------VA---E-E-----TP---------DG----------- PKACg_Hsap -----------------------QE---E-S-----VN---------E--F--------- PKACb_Hsap ----------------T-AL---WD---R-S-----MK---------E--F--------- PKACa_Hsap -----------------------EQ---E-S-----VK---------E--F--------- Pka-C1_Dmel ------------------VD---AA---E-T-----VK---------E--F--------- Pka-C2_Dmel -------------------N---SK---E-D-----YN---------V--I--------- CG12069_Dmel -------------------S---PK---V-D-----YI---------L--I--------- PKA-C3_Dmel -----------------------LE---S-D-----YS---------EEDP--------- PRKX_Mmus -----------------------VK---T-K-----VS---------------------- PKACb_Mmus ----------------T-AS---WD---K-S-----MK---------E--F--------- PKACa_Mmus -----------------------EQ---E-S-----VK---------E--F--------- kin-1_Cele ------------------NK---NS---A-S-----LK---------E--F--------- F47F2.1_Cele -----------------NSR---GN---N-Q-----VN---------E--L--------- TPK1_Scer -----------T-----QEK---PK---QPH-----VT---------YY-N--------- TPK2_Scer -----------------QQQ---QQ---R-Q-----HQ---------Q------------ TPK3_Scer -----------------SGK---LK---E-E-----AS---------A--G--------- DDB0185224_Ddis NNDNNNNNNNNNNNNNNNNN---NN---N-Q-----QQ---------Q--FY-------- pk4_Ddis QQQNIQQQQQQQQQKNQQQQ---QQ---Q-Q-----QQ---------Q--QQNNQQQQQN PKA_Ddis -----------------------LQ---Q-Q-----LQ---------QQQQ--------- 17649_Tthe -----------------------FVE--D-D-----LI---------SE-F--------- 18333_Tthe -----------------------FDDKEN-DYCNDLNK---------NE-F--------- 2171_Tthe -----------KARKNSASQHSYIH---N-K-----IK---------K--N--------- 26485_Tthe ------------------------------------------------------------ PRKX_Spur ------------------------------------------------------------ PKA_Spur ------------------------------------------------------------ CC1G_05183_Ccin -----------------QAQ---SQ---D-Q-----SN---------E--S--------- CC1G_04466_Ccin -----------------MGD---ES---V-A-----GG---------R--F--------- CC1G_01089_Ccin ------------------EE---KK---E-D-----GYVLVAAGKLGR--V--------- AqueK013_Aque ------------------QN---EQ---S-N-----SN---------S--F--------- AqueK014_Aque ----------------A-PG---KP---D-V-----VQ---------A--F--------- AqueK015_Aque -----------------ASE---LA---R-H-----LG---------Q--V--------- PKA-1_Smoe ------------------------------------------------------------ PKA-2_Smoe ------------------------------------------------------------ GK005_Glam ------------------------------------------------------------ GK006_Glam -------------------G---F----K-D-----AD---------------------- PRKY_Hsap ------------------------------------------------------------ PRKX_Hsap ------------------------------------------------------------ PKACg_Hsap ------------------------------------------------------------ PKACb_Hsap ------------------------------------------------------------ PKACa_Hsap ------------------------------------------------------------ Pka-C1_Dmel ------------------------------------------------------------ Pka-C2_Dmel ------------------------------------------------------------ CG12069_Dmel ------------------------------------------------------------ PKA-C3_Dmel ------------------------------------------------------------ PRKX_Mmus ------------------------------------------------------------ PKACb_Mmus ------------------------------------------------------------ PKACa_Mmus ------------------------------------------------------------ kin-1_Cele ------------------------------------------------------------ F47F2.1_Cele ------------------------------------------------------------ TPK1_Scer ------------------------------------------------------------ TPK2_Scer ------------------------------------------------------------ TPK3_Scer ------------------------------------------------------------ DDB0185224_Ddis ------------------------------------NAPSSNSTPSHSSPSSPT------ pk4_Ddis NQQQQQNNQQQQQHQQQNSQQQQNNQHQQQLQQQQYQQKHYNNNNNNNNNNQPQTSNQNI PKA_Ddis ------------------------------------------------------------ 17649_Tthe ------------------------------------------------------------ 18333_Tthe ------------------------------------------------------------ 2171_Tthe ------------------------------------------------------------ 26485_Tthe ------------------------------------------------------------ PRKX_Spur ------------------------------------------------------------ PKA_Spur ------------------------------------------------------------ CC1G_05183_Ccin ------------------------------------------------------------ CC1G_04466_Ccin ------------------------------------------------------------ CC1G_01089_Ccin ------------------------------------------------------------ AqueK013_Aque ------------------------------------------------------------ AqueK014_Aque ------------------------------------------------------------ AqueK015_Aque ------------------------------------------------------------ PKA-1_Smoe ------------------------------------------------------------ PKA-2_Smoe ------------------------------------------------------------ GK005_Glam ------------------------------------------------------------ GK006_Glam ------------------------------------------------------------ PRKY_Hsap ------------------------------------------------------------ PRKX_Hsap ------------------------------------------------------------ PKACg_Hsap -----------------------------------L--AKA------------------- PKACb_Hsap -----------------------------------L--AKA------------------- PKACa_Hsap -----------------------------------L--AKA------------------- Pka-C1_Dmel -----------------------------------L--EQA------------------- Pka-C2_Dmel -----------------------------------L--DNM------------------- CG12069_Dmel -----------------------------------L--DKL------------------- PKA-C3_Dmel -----------------------------------EQEQQRP------------------ PRKX_Mmus ------------------------------------------------------------ PKACb_Mmus -----------------------------------L--AKA------------------- PKACa_Mmus -----------------------------------L--AKA------------------- kin-1_Cele -----------------------------------L--DKA------------------- F47F2.1_Cele -----------------------------------A--EET------------------- TPK1_Scer -----------------------------------E--EQY------------------- TPK2_Scer --------------------------------------LLT------------------- TPK3_Scer -----------------------------------I--CLV------------------- DDB0185224_Ddis ----------------TSSIPFH----------PNF--TLS------------------- pk4_Ddis QHSQGLNYNQNQNQNQNQEAPIVVNSLILRSIGMMT--SKI------------------- PKA_Ddis -----------------------------------QQQQQQQQQQQKQQKQQQQQQQHLH 17649_Tthe -----------------------------------NHLIEI------------------- 18333_Tthe -----------------------------------NKNFEK------------------- 2171_Tthe -----------------------------------E--AEN------------------- 26485_Tthe ------------------------------------------------------------ PRKX_Spur ------------------------------------------------------------ PKA_Spur ------------------------------------------------------------ CC1G_05183_Ccin -----------------------------------Q--NRP------------------- CC1G_04466_Ccin -----------------------------------G--IEA------------------- CC1G_01089_Ccin -----------------------------------YKSAYD------------------- AqueK013_Aque -----------------------------------V--SLI------------------- AqueK014_Aque -----------------------------------L--VEA------------------- AqueK015_Aque -----------------------------------S--LES------------------- PKA-1_Smoe ------------------------------------------------------------ PKA-2_Smoe ------------------------------------------------------------ GK005_Glam ------------------------------------------------------------ GK006_Glam ------------------------------------------------------------ PRKY_Hsap ------------------------------------------------------------ PRKX_Hsap ------------------------------------------------------------ PKACg_Hsap ------------------------------------------------------------ PKACb_Hsap ------------------------------------------------------------ PKACa_Hsap ------------------------------------------------------------ Pka-C1_Dmel ------------------------------------------------------------ Pka-C2_Dmel ------------------------------------------------------------ CG12069_Dmel ------------------------------------------------------------ PKA-C3_Dmel ------DPATNSRSSSTATTTTTSSADHDNDVDEEDEEDDENEGEGNGRDADDATHDSSE PRKX_Mmus ------------------------------------------------------------ PKACb_Mmus ------------------------------------------------------------ PKACa_Mmus ------------------------------------------------------------ kin-1_Cele ------------------------------------------------------------ F47F2.1_Cele ------------------------------------------------------------ TPK1_Scer ------------------------------------------------------------ TPK2_Scer ------------------------------------------------------------ TPK3_Scer ------------------------------------------------------------ DDB0185224_Ddis ------------------------------------------------------------ pk4_Ddis ------------------------------------------------------------ PKA_Ddis QDGIVNTPSTTQTSTTTTTTTTT-TNPHTSGLSLQH---------------------AHS 17649_Tthe ------------------------------------------------------------ 18333_Tthe --NSDYYPTQK------------------------------------------------- 2171_Tthe ------------------------------------------------------------ 26485_Tthe ------------------------------------------------------------ PRKX_Spur ------------------------------------------------------------ PKA_Spur ------------------------------------------------------------ CC1G_05183_Ccin ------------------------------------------------------------ CC1G_04466_Ccin ------------------------------------------------------------ CC1G_01089_Ccin ------------------------------------------------------------ AqueK013_Aque ------------------------------------------------------------ AqueK014_Aque ------------------------------------------------------------ AqueK015_Aque ------------------------------------------------------------ PKA-1_Smoe ------------------------------------------------------------ PKA-2_Smoe ------------------------------------------------------------ GK005_Glam ------------------------------------------------------------ GK006_Glam ------------------------------------------------------------ PRKY_Hsap ----------------------------------------A---------PA---LC--- PRKX_Hsap ----------------------------------------A---------PA---LC--- PKACg_Hsap ----------------------------------------R---------GD---FL--- PKACb_Hsap ----------------------------------------K---------ED---FL--- PKACa_Hsap ----------------------------------------K---------ED---FL--- Pka-C1_Dmel ----------------------------------------K---------EE---FE--- Pka-C2_Dmel ----------------------------------------S---------RE---FE--- CG12069_Dmel ----------------------------------------R---------ED---FN--- PKA-C3_Dmel S--------------------IE-----EDDGNETDDEEDD---------DE---SE--- PRKX_Mmus ----------------------------------------A---------PA---AD--- PKACb_Mmus ----------------------------------------K---------ED---FL--- PKACa_Mmus ----------------------------------------K---------ED---FL--- kin-1_Cele ----------------------------------------R---------ED---FK--- F47F2.1_Cele ------------------------------------------------------------ TPK1_Scer --------------------------------------------------------K--- TPK2_Scer --------------------------------------------------------S--- TPK3_Scer --------------------------------------------------------K--- DDB0185224_Ddis ----------------------------------------Q---------DN---FN--- pk4_Ddis ----------------------------------------S---------KD---FE--- PKA_Ddis SYTPSNVLHSPTHFQSSLPTRLDTNPITTPIRQQQQSQQQLQQQQ-----LQ---QI--- 17649_Tthe -------------------------P-----------------------------LN--- 18333_Tthe ------------------------NPLEQIE---FQAKQNIQYAYTQKQKNN---QN--- 2171_Tthe ------------------------------------------------------------ 26485_Tthe ------------------------------------------------------------ PRKX_Spur ------------------------------------------------------------ PKA_Spur ------------------------------------------------------------ CC1G_05183_Ccin ----------------------------------------Q---------RC---L---- CC1G_04466_Ccin --------------------------------------------------------P--- CC1G_01089_Ccin ----------------------------------------E---------ER---FEKPV AqueK013_Aque ----------------------------------------E---------EDEENWD--- AqueK014_Aque ----------------------------------------K---------TE---FQ--- AqueK015_Aque ----------------------------------------S---------PI---LS--- PKA-1_Smoe ------------------------------------------------------------ PKA-2_Smoe ------------------------------------------------------------ GK005_Glam ------------------------------------------------------------ GK006_Glam ------------------------------------------------------------ PRKY_Hsap ------------------------------------------------------------ PRKX_Hsap ------------------------------------------------------------ PKACg_Hsap ------------------------------------------------------------ PKACb_Hsap ------------------------------------------------------------ PKACa_Hsap ------------------------------------------------------------ Pka-C1_Dmel ------------------------------------------------------------ Pka-C2_Dmel ------------------------------------------------------------ CG12069_Dmel ------------------------------------------------------------ PKA-C3_Dmel ------------------------------------------------------------ PRKX_Mmus ------------------------------------------------------------ PKACb_Mmus ------------------------------------------------------------ PKACa_Mmus ------------------------------------------------------------ kin-1_Cele ------------------------------------------------------------ F47F2.1_Cele ------------------------------------------------------------ TPK1_Scer ------------------------------------------------------------ TPK2_Scer ------------------------------------------------------------ TPK3_Scer ------------------------------------------------------------ DDB0185224_Ddis --Q--------------------------------------------------------- pk4_Ddis --ELTTFMKSSCPMLLRFSGVENSYHILEKLNNIITQSLEGLPKTPQCSQPPFNQLIPLS PKA_Ddis ------------------------------------------------------------ 17649_Tthe ------------------------------------------------------------ 18333_Tthe ------------------------------------------------------------ 2171_Tthe ------------------------------------------------------------ 26485_Tthe ------------------------------------------------------------ PRKX_Spur ------------------------------------------------------------ PKA_Spur ------------------------------------------------------------ CC1G_05183_Ccin ------------------------------------------------------------ CC1G_04466_Ccin ------------------------------------------------------------ CC1G_01089_Ccin PDP--------------------------------------------------------- AqueK013_Aque ------------------------------------------------------------ AqueK014_Aque ------------------------------------------------------------ AqueK015_Aque ------------------------------------------------------------ PKA-1_Smoe ------------------------------------------------------------ PKA-2_Smoe ------------------------------------------------------------ GK005_Glam ------------------------------------------------------------ GK006_Glam ------------------------------------------------------------ PRKY_Hsap ------------------------------------------------------------ PRKX_Hsap ------------------------------------------------------------ PKACg_Hsap ------------------------------------------------------------ PKACb_Hsap ------------------------------------------------------------ PKACa_Hsap ------------------------------------------------------------ Pka-C1_Dmel ------------------------------------------------------------ Pka-C2_Dmel ------------------------------------------------------------ CG12069_Dmel ------------------------------------------------------------ PKA-C3_Dmel ------------------------------------------------------------ PRKX_Mmus ------------------------------------------------------------ PKACb_Mmus ------------------------------------------------------------ PKACa_Mmus ------------------------------------------------------------ kin-1_Cele ------------------------------------------------------------ F47F2.1_Cele ------------------------------------------------------------ TPK1_Scer ------------------------------------------------------------ TPK2_Scer ------------------------------------------------------------ TPK3_Scer ------------------------------------------------------------ DDB0185224_Ddis ------------------------------------------------------------ pk4_Ddis NTTTLTPNNYNNNNNNSNNNNNSNNNNNNNSNNNNSNNNNSNNSNNNNNNSNNNNSNNNN PKA_Ddis ------------------------------------------------------------ 17649_Tthe ------------------------------------------------------------ 18333_Tthe ------------------------------------------------------------ 2171_Tthe ------------------------------------------------------------ 26485_Tthe ------------------------------------------------------------ PRKX_Spur ------------------------------------------------------------ PKA_Spur ------------------------------------------------------------ CC1G_05183_Ccin ------------------------------------------------------------ CC1G_04466_Ccin ------------------------------------------------------------ CC1G_01089_Ccin ------------------------------------------------------------ AqueK013_Aque ------------------------------------------------------------ AqueK014_Aque ------------------------------------------------------------ AqueK015_Aque ------------------------------------------------------------ PKA-1_Smoe ------------------------------------------------------------ PKA-2_Smoe ------------------------------------------------------------ GK005_Glam ------------------------------------------------------------ GK006_Glam ------------------------------------------------------------ PRKY_Hsap ------------------------------------------------------------ PRKX_Hsap ------------------------------------------------------------ PKACg_Hsap ------------------------------------------------------------ PKACb_Hsap ------------------------------------------------------------ PKACa_Hsap ------------------------------------------------------------ Pka-C1_Dmel ------------------------------------------------------------ Pka-C2_Dmel ------------------------------------------------------------ CG12069_Dmel ------------------------------------------------------------ PKA-C3_Dmel ------------------------------------------------------------ PRKX_Mmus ------------------------------------------------------------ PKACb_Mmus ------------------------------------------------------------ PKACa_Mmus ------------------------------------------------------------ kin-1_Cele ------------------------------------------------------------ F47F2.1_Cele ------------------------------------------------------------ TPK1_Scer ------------------------------------------------------------ TPK2_Scer ------------------------------------------------------------ TPK3_Scer ------------------------------------------------------------ DDB0185224_Ddis -------------------------------------------QLQNNNNSNNNSNNNNN pk4_Ddis SNNNNSNNNNNNSNNNNSNNNNSSNNNNNYSGFNDQQQQQQQQQQQQQQQQQQQ------ PKA_Ddis ------------------------------------------------------------ 17649_Tthe ------------------------------------------------------------ 18333_Tthe ------------------------------------------------------------ 2171_Tthe ------------------------------------------------------------ 26485_Tthe ------------------------------------------------------------ PRKX_Spur ------------------------------------------------------------ PKA_Spur ------------------------------------------------------------ CC1G_05183_Ccin ------------------------------------------------------------ CC1G_04466_Ccin ------------------------------------------------------------ CC1G_01089_Ccin ------------------------------------------------------------ AqueK013_Aque ------------------------------------------------------------ AqueK014_Aque ------------------------------------------------------------ AqueK015_Aque ------------------------------------------------------------ PKA-1_Smoe ------------------------------------------------------------ PKA-2_Smoe ------------------------------------------------------------ GK005_Glam ------------------------------------------------------------ GK006_Glam ------------------------------------------------------------ PRKY_Hsap ------P---------SPE----------------------------------------- PRKX_Hsap ------P---------SPE----------------------------------------- PKACg_Hsap ----------------YR------------------------------------------ PKACb_Hsap ----------------KK------------------------------------------ PKACa_Hsap ----------------KK------------------------------------------ Pka-C1_Dmel ----------------DK------------------------------------------ Pka-C2_Dmel ----------------ERW----------------------------------------- CG12069_Dmel ----------------KKF----------------------------------------- PKA-C3_Dmel ------E---------SSS----------------------------------------- PRKX_Mmus ------P---------KPR----------------------------------------- PKACb_Mmus ----------------RK------------------------------------------ PKACa_Mmus ----------------KK------------------------------------------ kin-1_Cele ----------------QR------------------------------------------ F47F2.1_Cele ------H---------MKL----------------------------------------- TPK1_Scer ------Q---------FIA----------------------------------------- TPK2_Scer ------Q---------LPQ----------------------------------------- TPK3_Scer ------K---------PML----------------------------------------- DDB0185224_Ddis NNIINNNFLQNSQQTNQSLQF---S----------------------------TTQPNL- pk4_Ddis --------QQQQQQQHQQQKHQQTQHSQQHQQQYQQHIQQNNQYQQNQNITQSSQIPQFK PKA_Ddis ------P---------PPT----------------------------------------- 17649_Tthe ----------------QQG----------------------------------------- 18333_Tthe ------Q---------AQI----------------------------------------- 2171_Tthe ------R---------NQI----------------------------------------- 26485_Tthe ------------------------------------------------------------ PRKX_Spur ------------------------------------------------------------ PKA_Spur ------------------------------------------------------------ CC1G_05183_Ccin ----------------EDQ----------------------------------------- CC1G_04466_Ccin ------R---------FSA----------------------------------------- CC1G_01089_Ccin ------E---------LVQ----------------------------------------- AqueK013_Aque ----------------DF------------------------------------------ AqueK014_Aque ----------------RK------------------------------------------ AqueK015_Aque ------G---------AGS----------------------------------------- PKA-1_Smoe ------------------------------------------------------------ PKA-2_Smoe ------------------------------------------------------------ GK005_Glam ------------------------------------------------------------ GK006_Glam ------------------------------------------------------------ PRKY_Hsap ------------------------------------------------------------ PRKX_Hsap ------------------------------------------------------------ PKACg_Hsap ------------------------------------------------------------ PKACb_Hsap ------------------------------------------------------------ PKACa_Hsap ------------------------------------------------------------ Pka-C1_Dmel ------------------------------------------------------------ Pka-C2_Dmel ------------------------------------------------------------ CG12069_Dmel ------------------------------------------------------------ PKA-C3_Dmel ------------------------------------------------------------ PRKX_Mmus ------------------------------------------------------------ PKACb_Mmus ------------------------------------------------------------ PKACa_Mmus ------------------------------------------------------------ kin-1_Cele ------------------------------------------------------------ F47F2.1_Cele ------------------------------------------------------------ TPK1_Scer ------------------------------------------------------------ TPK2_Scer ------------------------------------------------------------ TPK3_Scer ------------------------------------------------------------ DDB0185224_Ddis ------------------------------------------------NNFYDIPKQPII pk4_Ddis SNNIQSLIHNNQQHYTQNNLVNNNNNTNNNNNNNNYNNKTYYQPSVHENQYMASAIAPIH PKA_Ddis ------------------------------------------------------------ 17649_Tthe ------------------------------------------------------------ 18333_Tthe ------------------------------------------------------------ 2171_Tthe ------------------------------------------------------------ 26485_Tthe ------------------------------------------------------------ PRKX_Spur ------------------------------------------------------------ PKA_Spur ------------------------------------------------------------ CC1G_05183_Ccin ------------------------------------------------------------ CC1G_04466_Ccin ------------------------------------------------------------ CC1G_01089_Ccin ------------------------------------------------------------ AqueK013_Aque ------------------------------------------------------------ AqueK014_Aque ------------------------------------------------------------ AqueK015_Aque ------------------------------------------------------------ PKA-1_Smoe ------------------------------------------------------------ PKA-2_Smoe ------------------------------------------------------------ GK005_Glam ------------------------------------------------------------ GK006_Glam ------------------------------------------------------------ PRKY_Hsap --------------------A-------------------------R-S-P-EAP----- PRKX_Hsap --------------------A-------------------------L-S-P-EPP----- PKACg_Hsap --------------------W-------------------------G-N-P-AQN----- PKACb_Hsap --------------------W-------------------------E-N-P-TQN----- PKACa_Hsap --------------------W-------------------------E-S-P-AQN----- Pka-C1_Dmel --------------------W-------------------------R-R-N-PTN----- Pka-C2_Dmel --------------------N-------------------------H-Q-T-QSP----- CG12069_Dmel --------------------A-------------------------T-N-T-PSP----- PKA-C3_Dmel --------------------V-------------------------QTA-K-GVR----- PRKX_Mmus --------------------T---------------------------S-S-QKA----- PKACb_Mmus --------------------W-------------------------E-N-P-PPS----- PKACa_Mmus --------------------W-------------------------E-T-P-SQN----- kin-1_Cele --------------------W-------------------------E-N-P-AQN----- F47F2.1_Cele --------------------S-------------------------I-T-P-TRE----- TPK1_Scer --------------------Q-------------------------A-R-V-TVG----- TPK2_Scer --------------------K-------------------------S-L-V-SKG----- TPK3_Scer --------------------Q-------------------------Y-R-D-TSG----- DDB0185224_Ddis CSSPIVNIPPPFYLDGSIDPV-------------------------E-N-I-DWK----- pk4_Ddis ---NHQSSPNPFYQQKLTIPQQTNNQSTRISAQFIIQNINNQQIQGT-Y-I-NFN----- PKA_Ddis ----------------VNSFF-------------------------LPP-P-VNA----- 17649_Tthe --------------------K-------------------------I-Q-T-KSD----- 18333_Tthe --------------------I-------------------------K-K-E-QND----- 2171_Tthe --------------------K-------------------------N-F-K-AKAACIKI 26485_Tthe ------------------------------------------------------------ PRKX_Spur ------------------------------------------------------------ PKA_Spur ------------------------------------------------------------ CC1G_05183_Ccin --------------------R-------------------------V-R-L-QGS----- CC1G_04466_Ccin --------------------R-------------------------P-Q-R-PKG----- CC1G_01089_Ccin --------------------P-------------------------V-S-K-RPP----- AqueK013_Aque --------------------S-------------------------E-HLPTESD----- AqueK014_Aque --------------------W-------------------------E-S-P-PAQ----- AqueK015_Aque --------------------R-------------------------E-A-R-YTR----- PKA-1_Smoe ------------------------------------------------------------ PKA-2_Smoe ------------------------------------------------------------ GK005_Glam ----------------------------------------------------AYP----- GK006_Glam ----------------------------------------------A-Y-I-DPP----- PRKY_Hsap ----------------AYRLQDCDALVTMGTGTFGRV--HLVKEKT-------AKHFFAL PRKX_Hsap ----------------VYSLQDFDTLATVGTGTFGRV--HLVKEKT-------AKHFFAL PKACg_Hsap ----------------TASSDQFERLRTLGMGSFGRV--MLVRHQE-------TGGHYAM PKACb_Hsap ----------------NAGLEDFERKKTLGTGSFGRV--MLVKHKA-------TEQYYAM PKACa_Hsap ----------------TAHLDQFERIKTLGTGSFGRV--MLVKHKE-------TGNHYAM Pka-C1_Dmel ----------------TAALDDFERIKTLGTGSFGRV--MIVQHKP-------TKDYYAM Pka-C2_Dmel ----------------YTNLENYITRAVLGNGSFGTV--MLVREKSG-------KNYYAA CG12069_Dmel ----------------STGLDDYEIKATLGSGSFGKV--QLVRERES-------GVYYAS PKA-C3_Dmel ----------------KYHLDDYQIIKTVGTGTFGRV--CLCRDRI-------SEKYCAM PRKX_Mmus ----------------GHSLQDWDTIATVGTGTFGRV--NLVKEKT-------GRQYCAL PKACb_Mmus ----------------NAGLEDFERKKTLGTGSFGRV--MLVKHKA-------TEQYYAM PKACa_Mmus ----------------TAQLDQFDRIKTLGTGSFGRV--MLVKHKE-------SGNHYAM kin-1_Cele ----------------TACLDDFDRIKTLGTGSFGRV--MLVKHKQ-------SGNYYAM F47F2.1_Cele ----------------SFSLSQLERIITIGKGTFGRV--ELARDKI-------TGAHYAL TPK1_Scer ----------------SIVYKNFQILRTLGTGSFGRV--HLIRSRH-------NGRYYAM TPK2_Scer ----------------KYTLHDFQIMRTLGTGSFGRV--HLVRSVH-------NGRYYAI TPK3_Scer ----------------KYSLSDFQILRTLGTGSFGRV--HLIRSNH-------NGRFYAL DDB0185224_Ddis ----------------RTKISDFNFYGSLGSGSFGTA--KLCRHRG-------SGLFFCS pk4_Ddis ----------------SCKLSDFKLFDLLGSGSFAKV--RLCQHIP-------SERLFCM PKA_Ddis ----------------RERLKEFKQIRVIGTGTFGKV--YLIQNTK-------DGCYYAM 17649_Tthe ----------------TMKISDFEIFATLGTGTFGRV--RQVKLKGDT-----NKEIFAL 18333_Tthe ----------------TLNLNQFNIKTTLGTGSFGRV--KLAKLKGN------EKDVFAL 2171_Tthe QSLITLLIKNNFSTFLLFCESSKKQQQSINRCSFGRV--RLAKQKS-------TGEYVAL 26485_Tthe -------------------LSDYEIFQTLGTGSFGRV--KLAKKKN-------TTQYVAL PRKX_Spur ------------------------------------------------------------ PKA_Spur ------------------------------------------------------------ CC1G_05183_Ccin ----------------GLKLSDFEVRGTLGTGTFGKV--LLVRHKTARDR-HGAQSHFAM CC1G_04466_Ccin ----------------TYRLSDFSIQRTLGTGSFGRV--HLVRSKH-------NGRFYAI CC1G_01089_Ccin ----------------PLGLQDLEIIKALGDGAEGRV--YLVRTTRSSHPLDRPGTLYAV AqueK013_Aque ----------------SIPLIDFSDDGPLNEGANPPNYWDIISHSA-----NLADESHAP AqueK014_Aque ----------------TGKLDDFDRIKTLGTGSFGRV--MLVQHKK-------TSKYYAM AqueK015_Aque ----------------KFSLRELEIQQTIGTGTFGRV--VLTREIS-------SRQYYAL PKA-1_Smoe -------------------IEEFELGRVLGTGSFGRV--QVAHHKA-------NKQVCAV PKA-2_Smoe -------------------IEEFELGRVLGTGSFGRV--QVAHHKA-------NKQVCAV GK005_Glam ----------------ELSYKDLRHIKNIGSGSFGRV--TLAQHID-------TGKYYAV GK006_Glam ----------------PTSPDEFTFMKVLGKGSFGTV--CLAKHKA-------NNKIYAL PRKY_Hsap KVM-------------------SIPDV-IRRKQ----EQH---VHNEKSVLKEVS-HPFL PRKX_Hsap KVM-------------------SIPDV-IRLKQ----EQH---VHNEKSVLKEVS-HPFL PKACg_Hsap KIL-------------------NKQKV-VKMKQ----VEH---ILNEKRILQAID-FPFL PKACb_Hsap KIL-------------------DKQKV-VKLKQ----IEH---TLNEKRILQAVN-FPFL PKACa_Hsap KIL-------------------DKQKV-VKLKQ----IEH---TLNEKRILQAVN-FPFL Pka-C1_Dmel KIL-------------------DKQKV-VKLKQ----VEH---TLNEKRILQAIQ-FPFL Pka-C2_Dmel KMM-------------------SKEDL-VRLKQ----VAH---VHNEKHVLNAAR-FPFL CG12069_Dmel KQL-------------------SKDQI-VKTKQ----VSH---VMSEKNVLRSMT-FPNT PKA-C3_Dmel KIL-------------------AMTEV-IRLKQ----IEH---VKNERNILREIR-HPFV PRKX_Mmus KIM-------------------SIPDV-IRLKQ----EQH---VQNEKAVLKEIN-HPFL PKACb_Mmus KIL-------------------DKQKV-VKLKQ----IEH---TLNEKRILQAVE-FPFL PKACa_Mmus KIL-------------------DKQKV-VKLKQ----IEH---TLNEKRILQAVN-FPFL kin-1_Cele KIL-------------------DKQKV-VKLKQ----VEH---TLNEKRILQAID-FPFL F47F2.1_Cele KVL-------------------NIRRV-VDMRQ----TQH---VHNEKRVLLQLK-HPFI TPK1_Scer KVL-------------------KKEIV-VRLKQ----VEH---TNDERLMLSIVT-HPFI TPK2_Scer KVL-------------------KKQQV-VKMKQ----VEH---TNDERRMLKLVE-HPFL TPK3_Scer KTL-------------------KKHTI-VKLKQ----VEH---TNDERRMLSIVS-HPFI DDB0185224_Ddis KTL-------------------RRETI-VHEKH----KEH---VNNEINIMLNIS-HPYI pk4_Ddis KIL-------------------NQNKI-IRLRQ----EVH---VCNEKQVLMLTD-NPFI PKA_Ddis KCL-------------------NKAYV-VQLKQ----VEH---LNSEKSILSSIH-HPFI 17649_Tthe KML-------------------KKTEI-VRLNQ----VEH---INSEKKILQSVK-HPFI 18333_Tthe KMM-------------------KKIEI-VKLKQ----VEH---IKSEKKILSQIK-HPFL 2171_Tthe KML-------------------KKAEI-LRLKQ----VDH---IISENTILSNIN-HPFL 26485_Tthe KVL-------------------KKAEI-IRLKQ----VDH---IINENTILSNLN-HPFI PRKX_Spur ------------------------------------------------------------ PKA_Spur ------------------------------------------------------------ CC1G_05183_Ccin KVL-------------------RKTVI-VQLRQ----VEH---VNAERYILSRVN-HPFI CC1G_04466_Ccin KVL-------------------NKERI-VRMKQ----IEH---TNNEMKMLESVQ-HPFI CC1G_01089_Ccin KTQ-------------------KKKYKRQALPP----EAHMLEKDNERTALALMDWNPFI AqueK013_Aque AILSAIKGIVDEWDIVGIFLGIDNANI-ERIKSNNSNVDH---RRKEI-IIAWLR-YGNA AqueK014_Aque KIL-------------------DKQKV-VKLKQ----VEH---TLNEKRILSSIN-FPFV AqueK015_Aque KIM-------------------SIAEV-IRLKQ----VEH---VNNEKEILTSLQ-HPFI PKA-1_Smoe KSL-------------------SKASI-VKTKQ----ACE---HSFQKNILQRLD-FPYI PKA-2_Smoe KSL-------------------SKASI-VKTKQ----ACE---HSFQKNILQRLD-FPYI GK005_Glam KAM-------------------SKRKI-IALRQ----VAH---INNECSILRVVR-SPFI GK006_Glam KVL-------------------TKQHV-IESRE----VEH---AISERSILASLN-HPFL PRKY_Hsap I--R-LF------------WTWHEERFLYMLMEYVPGGELFSYLRNRGHFSSTTGLFYSA PRKX_Hsap I--R-LF------------WTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSA PKACg_Hsap V--K-LQ------------FSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAA PKACb_Hsap V--R-LE------------YAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAA PKACa_Hsap V--K-LE------------FSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAA Pka-C1_Dmel V--S-LR------------YHFKDNSNLYMVLEYVPGGEMFSHLRKVGRFSEPHSRFYAA Pka-C2_Dmel I--Y-LV------------DSTKCFDYLYLILPLVNGGELFSYHRRVRKFNEKHARFYAA CG12069_Dmel V--N-LI------------ASYKDFDSLYLVLPLIGGGELFTYHRKVRKFTEKQARFYAA PKA-C3_Dmel I--S-LE------------WSTKDDSNLYMIFDYVCGGELFTYLRNAGKFTSQTSNFYAA PRKX_Mmus I--K-LL------------WTGHDNRFLYMLMEFVPGGELFTYLRNRGRFSSVASVFYAT PKACb_Mmus V--R-LE------------YSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAA PKACa_Mmus V--K-LE------------FSFKDNSNLYMVMEYVAGGEMFSHLRRIGRFSEPHARFYAA kin-1_Cele V--N-MT------------FSFKDNSNLYMVLEFISGGEMFSHLRRIGRFSEPHSRFYAA F47F2.1_Cele V--K-MY------------ASEKDSNHLYMIMEFVPGGEMFSYLRASRSFSNSMARFYAS TPK1_Scer I--R-MW------------GTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAA TPK2_Scer I--R-MW------------GTFQDARNIFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAA TPK3_Scer I--R-MW------------GTFQDSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAA DDB0185224_Ddis V--K-TY------------STFNTPTKIHFIMEYAGKKDLFHHLRANKCFTEQTTKLIVA pk4_Ddis V--K-LY------------STFKDDRYLYFLQEFIPGGELFDYIRANGSLSLYVTQIYAA PKA_Ddis V--N-LY------------QAFQDEKKLYLLFEYVAGGEVFTHLRKSMKFSNSTAKFYAA 17649_Tthe V--Q-MK------------QSFQDDKYIYMLFEYIQGGELFSRLRKEGRFSNDVGLFYTC 18333_Tthe V--E-LK------------GTFQDEIYIYMLFEFVSGGEIFSRLRKEGRFSNDISLFYIT 2171_Tthe V--N-LSTFYLHQQVIKMIGFTQDDRFLYFVLEYVAGGELFTYLRNKGKLDNPEALFYAA 26485_Tthe V--K-MD------------GFCQDSRYLYLVLEFVSGGELFTYLRSVGRLETNHACFYAA PRKX_Spur -----------------------------MLLEYACGGELFTYLRNSGRFNNDTGKFYAM PKA_Spur -----------------------------MVLDYIPGGEMFSHLRRIGRFSEPHSRFYAA CC1G_05183_Ccin V--D-LF------------ATFQDSLNVYMLMSYVPGGELFTHLRRAQRFTPDVTRFYLA CC1G_04466_Ccin I--N-LW------------GSFQDSSNLYMVMDFVPGGELFTLLRRSNRFPDPVAKFYAA CC1G_01089_Ccin A--G-VI------------DILHDVKNIYTILELIPSGTLLSLIKSHAPMPPTIAAFYFA AqueK013_Aque TRQHLIE------------ALKEDNSYLYMLLEFVSGGEMFSHLRRIGRFSESHSRFYAS AqueK014_Aque V--N-LE------------FHFKDNSYLYMLLEFVSGGEMFSHLRRIGRFSESHSRFYAS AqueK015_Aque V--N-LA------------WTHHDNRFLYMLLEYVPGGELFTYLRTAQRFDNATSMFFAS PKA-1_Smoe V--N-LL------------GYCQDDRCVHLVMEYVCGGEFFTYLRHTGRFDEATSRFYAS PKA-2_Smoe V--N-LL------------GYCQDDRCVHLVMEYVCGGEFFTYLRHTGRFDEATSRFYAS GK005_Glam I--R-QY------------GTYQDDKNVYIILDFIQGGELFYHLRRYNKFPLQVVKFFAV GK006_Glam M--R-LY------------GAFQTPTRLIMVLEYVPGGELFFHLKKKVTFDESYVKLVAA : .: : : : PRKY_Hsap EIIC-------------------------------------------------------- PRKX_Hsap EIIC-------------------------------------------------------- PKACg_Hsap QVVL-------------------------------------------------------- PKACb_Hsap QIVL-------------------------------------------------------- PKACa_Hsap QIVL-------------------------------------------------------- Pka-C1_Dmel QIVL-------------------------------------------------------- Pka-C2_Dmel QVAL-------------------------------------------------------- CG12069_Dmel QVFL-------------------------------------------------------- PKA-C3_Dmel EIVS-------------------------------------------------------- PRKX_Mmus EIVC-------------------------------------------------------- PKACb_Mmus QIVL-------------------------------------------------------- PKACa_Mmus QIVL-------------------------------------------------------- kin-1_Cele QIVL-------------------------------------------------------- F47F2.1_Cele EIVC-------------------------------------------------------- TPK1_Scer EVCL-------------------------------------------------------- TPK2_Scer EVIL-------------------------------------------------------- TPK3_Scer EVCL-------------------------------------------------------- DDB0185224_Ddis EIVL-------------------------------------------------------- pk4_Ddis EIVL-------------------------------------------------------- PKA_Ddis EIVL-------------------------------------------------------- 17649_Tthe QILL-------------------------------------------------------- 18333_Tthe EIYL-------------------------------------------------------- 2171_Tthe QVYIFVCDLLSYDNHFETQQINLKIRLSYFLLQQIQQMSQNQSKIFFQNNLRKNTNILPR 26485_Tthe QVTL-------------------------------------------------------- PRKX_Spur EIIS-------------------------------------------------------- PKA_Spur QIVL-------------------------------------------------------- CC1G_05183_Ccin TIIL-------------------------------------------------------- CC1G_04466_Ccin EVAL-------------------------------------------------------- CC1G_01089_Ccin NMFS-------------------------------------------------------- AqueK013_Aque QIVL-------------------------------------------------------- AqueK014_Aque QIVL-------------------------------------------------------- AqueK015_Aque EIVL-------------------------------------------------------- PKA-1_Smoe QVLL-------------------------------------------------------- PKA-2_Smoe QVLL-------------------------------------------------------- GK005_Glam EILL-------------------------------------------------------- GK006_Glam QLVL-------------------------------------------------------- : PRKY_Hsap ------------------------AIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFA PRKX_Hsap ------------------------AIEYLHSKEIVYRDLKPENILLDRDGHIKLTDFGFA PKACg_Hsap ------------------------AVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFA PKACb_Hsap ------------------------TFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFA PKACa_Hsap ------------------------TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFA Pka-C1_Dmel ------------------------AFEYLHYLDLIYRDLKPENLLIDSQGYLKVTDFGFA Pka-C2_Dmel ------------------------ALEYMHKMHLMYRDLKPENILLDQRGYIKITDFGFT CG12069_Dmel ------------------------ALEYLHHCSLLYRDLKPENIMMDKNGYLKVTDFGFA PKA-C3_Dmel ------------------------ALEYLHSLQIVYRDLKPENLLINRDGHLKITDFGFA PRKX_Mmus ------------------------AIEYLHSKEIVYRDLKPENILLDREGHIKLTDFGFA PKACb_Mmus ------------------------TFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFA PKACa_Mmus ------------------------TFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFA kin-1_Cele ------------------------AFEYLHSLDLIYRDLKPENLLIDSTGYLKITDFGFA F47F2.1_Cele ------------------------ALEYIHSLGIVYRDLKPENLMLSKEGHIKMADFGFA TPK1_Scer ------------------------ALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFA TPK2_Scer ------------------------ALEYLHAHNIIYRDLKPENILLDRNGHIKITDFGFA TPK3_Scer ------------------------ALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFA DDB0185224_Ddis ------------------------AIEYLHAENIIYRDLKPENILIDEKGHIKLTDFGFS pk4_Ddis ------------------------ALEYLHNQDIIYRDLKPENLLIDQYGHIKLTDFGFA PKA_Ddis ------------------------ALEFLHKQNIVYRDLKPENLLIDNQGHIKITDFGFA 17649_Tthe ------------------------ALQYLHQHDIVYRDLKPENLLIDKEGNIKITDFGFA 18333_Tthe ------------------------ALQYLHSQNIVYRDLKPENLLIDKEGHVKIADFGFA 2171_Tthe QYFYLTNQIKQPKIETKKRYFKVSMFEYLHNKNIVYRDLKPENILIGSDGYLKLTDFGFA 26485_Tthe ------------------------MFEYLHTKNIIYRDLKPENLLIADDGYLKLTDFGFA PRKX_Spur ------------------------AIDYLHKETIVYRDLKPENILLDSEGHVKLTDFGFA PKA_Spur ------------------------AFEYLHHLDLIYRDLKPENILIQENGYIAVTDFGFA CC1G_05183_Ccin ------------------------ALKYLHSFNIIYRDLKPENLLLDSRGYLRLTDFGFA CC1G_04466_Ccin ------------------------ALNYMHSLDIVYRDLKPENILLNVDGHIKIADFGFA CC1G_01089_Ccin ------------------------AIEYVHALGLVHRDIKPDNFLLGEDGYLSLTDFGLT AqueK013_Aque ------------------------AFEYLHYLDIVYRDLKPENLLIDQHGYVKVTDFGFA AqueK014_Aque ------------------------AFEYLHYLDIVYRDLKPENLLIDQHGYVKVTDFGFA AqueK015_Aque ------------------------VMDYLHSQYIVYRDLKPENILIDSTGHIKLCDFGFA PKA-1_Smoe ------------------------AFEHIHGMDIIYRDLKPENLLLDEKGNIKIADFGFA PKA-2_Smoe ------------------------AFEHIHGMDIIYRDLKPENLLLDEKGNIKIADFGFA GK005_Glam ------------------------ALGYLHNLGIAYRDLKLENVLVDNTGHIKLADLGFA GK006_Glam ------------------------AIEYLHDMNIVIRDLKPENILLQANGYIKVTDFGLS . .:* : **:* :*.:: * : : *:*:: PRKY_Hsap KKL----------VDRT---WTLCGTPEYLAPEVIQS---------------KGHGRAVD PRKX_Hsap KKL----------VDRT---WTLCGTPEYLAPEVIQS---------------KGHGRAVD PKACg_Hsap KRVK----------GRT---WTLCGTPEYLAPEIILS---------------KGYNKAVD PKACb_Hsap KRVK----------GRT---WTLCGTPEYLAPEIILS---------------KGYNKAVD PKACa_Hsap KRVK----------GRT---WTLCGTPEYLAPEIILS---------------KGYNKAVD Pka-C1_Dmel KRVK----------GRT---WTLCGTPEYLAPEIILS---------------KGYNKAVD Pka-C2_Dmel KRVD----------GRT---STLCGTPEYLAPEIVQL---------------RPYNKSVD CG12069_Dmel KKVE----------TRT---MTLCGTPEYLPPEIIQS---------------KPYGTSVD PKA-C3_Dmel KKL----------RDRT---WTLCGTPEYIAPEIIQS---------------KGHNKAVD PRKX_Mmus KKL----------VDRT---WTLCGTPEYLAPEVIQS---------------KGHGRAVD PKACb_Mmus KRVK----------GRT---WTLCGTPEYLAPEIILS---------------KGYNKAVD PKACa_Mmus KRVK----------GRT---WTLCGTPEYLAPEIILS---------------KGYNKAVD kin-1_Cele KRVK----------GRT---WTLCGTPEYLAPEIILS---------------KGYNKAVD F47F2.1_Cele KELR----------DRT---YTICGTPDYLAPESLAR---------------TGHNKGVD TPK1_Scer KYVP----------DVT---YTLCGTPDYIAPEVVST---------------KPYNKSID TPK2_Scer KEVQ----------TVT---WTLCGTPDYIAPEVITT---------------KPYNKSVD TPK3_Scer KYVP----------DVT---YTLCGTPDYIAPEVVST---------------KPYNKSVD DDB0185224_Ddis KKTVG--------GKNT---SSVCGTFDYMAPEILNS-S-------------NGHGKPVD pk4_Ddis KRITE----------NT---KSMCGTPEYIAPEILS--G-------------HGHGKSAD PKA_Ddis KRV----------EDRT---FTLCGTPEYLAPEIIQS---------------KGHGKAVD 17649_Tthe KKLD---------NDRT---FTLCGTPEYLAPEIIKGSR-------------VGYGKSVD 18333_Tthe KIMD---------SART---YTLCGTPEYLAPEIIQGAK-------------TGYGKSVD 2171_Tthe KYCD----------SRT---YTLCGTPEYLAPEILLN---------------KGHGKPVD 26485_Tthe KVVE----------GRT---YTLCGTPEYLAPEILLN---------------KGHGKAVD PRKX_Spur KKLV---------DNRT---WTLCGTPEYLAPEIIQS---------------KGHGKAVD PKA_Spur KRVK----------GRT---WTLCGTPEYLAPEIILS---------------KGYNKAVD CC1G_05183_Ccin KIVD----------DRT---WTLCGTPEYLAPEIIQS---------------DGHGKAAD CC1G_04466_Ccin KLCA----------TTT---WTLCGTPDYLAPEIVSQ---------------QRYNKSVD CC1G_01089_Ccin VPVDDF--------QVD---WVDIGTPLYRPPEMDVRASPAQEKEGDEEEVDLDDRRSVD AqueK013_Aque KRVK----------GRT---WTLCGTPEYLAPEIILS----------------------- AqueK014_Aque KRVK----------GRT---WTLCGTPEYLAPEIILS---------------KGYNRAVD AqueK015_Aque KRLA---------DRRT---YTLCGTPEYLAPEIIQG---------------KGHGREVD PKA-1_Smoe KQID----------RRT---YTLCGTPDYLAPEIILN---------------KGHGKPVD PKA-2_Smoe KQID----------RRT---YTLCGTPDYLAPEIILN---------------KGHGKPVD GK005_Glam KRLVEKNADGDTVSQLT---FSIVGTPEYLAPEIIRS---------------TGHDMSAD GK006_Glam KQNL----------SMTLGAKTMAGTSEYFSPEQVQN---------------CGHGKGVD ** * .** PRKY_Hsap WWALGILIFEMLSGFPPFFD--DN-P--FGIYQKILAG--KLYFPR-HLD-----FHVKT PRKX_Hsap WWALGILIFEMLSGFPPFFD--DN-P--FGIYQKILAG--KIDFPR-HLD-----FHVKD PKACg_Hsap WWALGVLIYEMAVGFPPFYA--DQ-P--IQIYEKIVSG--RVRFPS-KLS-----SDLKH PKACb_Hsap WWALGVLIYEMAAGYPPFFA--DQ-P--IQIYEKIVSG--KVRFPS-HFS-----SDLKD PKACa_Hsap WWALGVLIYEMAAGYPPFFA--DQ-P--IQIYEKIVSG--KVRFPS-HFS-----SDLKD Pka-C1_Dmel WWALGVLVYEMAAGYPPFFA--DQ-P--IQIYEKIVSG--KVRFPS-HFG-----SDLKD Pka-C2_Dmel WWAFGILVYEFVAGRSPFAIHNRD-V--ILMYSKICIC--DYKMPS-YFT-----SQLRS CG12069_Dmel WWAFGVLVFEFVAGHSPFSAHNRD-V--MSMYNKICEA--DYKMPS-YFS-----GALRH PKA-C3_Dmel WWALGVLIYEMLVGYPPFYD--EQ-P--FGIYEKILSG--KIEWER-HMD-----PIAKD PRKX_Mmus WWALGILIFEMLSGFPPFFD--DN-P--FGIYQKILAC--KIDFPR-QLD-----FTSKD PKACb_Mmus WWALGVLIYEMAAGYPPFFA--DQ-P--IQIYEKIVSG--KVRFPS-HFS-----SDLKD PKACa_Mmus WWALGVLIYEMAAGYPPFFA--DQ-P--IQIYEKIVSG--KVRFPS-HFS-----SDLKD kin-1_Cele WWALGVLIYEMAAGYPPFFA--DQ-P--IQIYEKIVSG--KVKFPS-HFS-----NELKD F47F2.1_Cele WWALGILIYEMMVGKPPFRG--KT-T--SEIYDAIIEH--KLKFPR-SFN-----LAAKD TPK1_Scer WWSFGILIYEMLAGYTPFYD--SN-T--MKTYEKILNA--ELRFPP-FFN-----EDVKD TPK2_Scer WWSLGVLIYEMLAGYTPFYD--TT-P--MKTYEKILQG--KVVYPP-YFH-----PDVVD TPK3_Scer WWSFGVLIYEMLAGYTPFYN--SN-T--MKTYENILNA--ELKFPP-FFH-----PDAQD DDB0185224_Ddis WWALGVVVYELVTGKLPFSN--SK-E--SLLNRKADFQ--LIFQNS-YLS-----DEIKD pk4_Ddis WWSLGILIYEMLVGVPPFVS--EGSQ--NDIFRLIREA--RIQVPP-EVD-----QVARD PKA_Ddis WWALGILIFEMLAGYPPFYD--DD-T--FAIYNKILAG--RITFPL-GFD-----VDAKD 17649_Tthe WWALGILVFEMLSGYPPFYD--NE-P--IGIYKKIIAG--IIEFPR-FFD-----NKAKD 18333_Tthe WWALGVLIFEMLSGHPPFYD--CD-P--MGIYQKIVNS--VINFPE-FFS-----LRAKD 2171_Tthe WWCLGILIYEMLAGIDPFND--ED-P--MAIYQKILKG--KVKFPR-NFD-----KNAKS 26485_Tthe WWTLGILIYEMNAGIDPFTD--ED-P--MAIYQKILKG--KVKFPR-NFD-----KNAKS PRKX_Spur WWALGILIYEMLAGYPPFYD--EN-P--FGIYEKILAC--KIDWPQ-SIG-----SKPKK PKA_Spur WWALGVLIYEMAAGYPPFFA--DQ-P--IQIYEKIVSG--KVRFPS-HFS-----ADLKD CC1G_05183_Ccin WWACGVLCYEMLVGYPPFFD--ES-P--YGIYEKILNG--QIHWPR-HID-----RLSKD CC1G_04466_Ccin WYALGVLIFEMLSGLPPYHQ--PE-PNHLALYEKIMRGPKNIRWPAAAFN-----ENATD CC1G_01089_Ccin WYSSAVVLYEMVTRTVPFYG--RT-K--LQTNALKVEK--KYSFPK-DIRI---GSHFKD AqueK013_Aque ------------------------------------------------------------ AqueK014_Aque WWAMGVLIYEMAAGYPPFFA--DQ-P--IQIYEKIVSG--KVRFPS-HFT-----ADLKD AqueK015_Aque WWALGILVYEMLVGYPPFFD--EH-P--FRIYEKILEG--KVDWPK-VIS-----STAKD PKA-1_Smoe WWAFGVLIYEMLAGYPPFYD--DD-A--IGTYQKILAG--KLQFPG-HFSRRQTSCSAKD PKA-2_Smoe WWAFGVLIYEMLAGYPPFYD--DD-A--IGTYQKILAG--KLQFPG-HFSRRQISCSAKD GK005_Glam WWAFGVLIYEMLTGSPPFFD--DN-P--DMTCKKILGG--KITFAS-GFD-----KAAKD GK006_Glam MWALGTIIYELLTGSPPFYS--DD-K--RAMFRKIIGE--QPKMPS-YFK-----DDLKD PRKY_Hsap ------------------------------------------------------------ PRKX_Hsap LIKKLLVVDRTRRLGN-MK--------NGANDVKHHRWFRSVDWEAVPQR-KLKPPI--- PKACg_Hsap LLRSLLQVDLTKRFGN-LR--------NGVGDIKNHKWFATTSWIAIYEK-KVEAPF--- PKACb_Hsap LLRNLLQVDLTKRFGN-LK--------NGVSDIKTHKWFATTDWIAIYQR-KVEAPF--- PKACa_Hsap LLRNLLQVDLTKRFGN-LK--------NGVNDIKNHKWFATTDWIAIYQR-KVEAPF--- Pka-C1_Dmel LLRNLLQVDLTKRYGN-LK--------AGVNDIKNQKWFASTDWIAIFQK-KIEAPF--- Pka-C2_Dmel LVESLMQVDTSKRLGN-SN--------DGSSDVKSHPWFQGVDWFGILNQ-EVTAPY--- CG12069_Dmel LVDHLLQVDLSKRFGN-LI--------NGNRDIKEHEWFKDVEWIPLLNQ-TVNAPY--- PKA-C3_Dmel LIKKLLVNDRTKRLGN-MK--------NGADDVKRHRWFKHLNWNDVYSK-KLKPPI--- PRKX_Mmus LIKKLLVVDRTRRLGN-MK--------NGAEDIKRHRWFRGVEWESVPQR-KLKPPI--- PKACb_Mmus LLRNLLQVDLTKRFGN-LK--------NGVSDIKTHKWFATTDWIAIYQR-KVEAPF--- PKACa_Mmus LLRNLLQVDLTKRFGN-LK--------NGVNDIKNHKWFATTDWIAIYQR-KVEAPF--- kin-1_Cele LLKNLLQVDLTKRYGN-LK--------NGVADIKNHKWFGSTDWIAIYQK-KITPPSFSK F47F2.1_Cele LVKKLLEVDRTQRIGC-MK--------NGTQDVKDHKWFEKVNWDDTLHL-RVEPPI--- TPK1_Scer LLSRLITRDLSQRLGN-LQ--------NGTEDVKNHPWFKEVVWEKLLSR-NIETPY--- TPK2_Scer LLSKLITADLTRRIGN-LQ--------SGSRDIKAHPWFSEVVWERLLAK-DIETPY--- TPK3_Scer LLKKLITRDLSERLGN-LQ--------NGSEDVKNHPWFNEVIWEKLLAR-YIETPY--- DDB0185224_Ddis FIFQLLSVDPSKRLGT-FD--------S--CSIRNHKWFSDINWLHLESKYQIDGPL--- pk4_Ddis LIEKLVVTDVEKRLGS-LE--------GGIEDIKNHPFFGAINWNSIQNR-E-SAPL--- PKA_Ddis LIKRLLTADRTRRLGA-LK--------DGALDVKNHRWFSDINWERLYQR-RDNGPF--- 17649_Tthe LIRKLLNPDLNYRLGV-H---------DKGQSVSKHKWFRGVDWESVFNK-DIPAPW--- 18333_Tthe LVRKLLNPNIESRLGC-QDQILSNVIDQDGNSIKNHKWFKGVNWDKIYHK-QIPSPW--- 2171_Tthe LVKHLLVADLTKRYGN-LK--------GGVNDIKTHRWFADMDWDALFHK-KIPPTY--- 26485_Tthe LVKHLLVADLSKRYGN-LK--------NGANDIKNHRWFSSIDWAQLLSK-KLPVPY--- PRKX_Spur LIEGLLVIDRTKRLGC-MR--------AGSNDIKNSDWFESIDWENVRQR-QLKPPI--- PKA_Spur ILRSLLQVDLTKRYGN-LK--------AGVADIKLHKWFQSTDWIAIYQQ-RVDAPF--- CC1G_05183_Ccin LIKSFLNPDRTKRLGN-ML--------GGPQDILDHPWFRGVDWDALERR-EINAPI--- CC1G_04466_Ccin LILKLMEGDPSRRYGN-LR--------HGAGDVFAHPWFREVDWDRLAAR-EITAPY--- CC1G_01089_Ccin LIKSLLDPEPSNRP--------------RPAEIQENKWLSRIDWDKLHEK-QYLPPH--- AqueK013_Aque ------------------------------------------------------------ AqueK014_Aque LLRNLLQVDLTKRFGN-LK--------NGVQDIKGHSWFSSTEWISIYQR-KIDAPF--- AqueK015_Aque LIKKLLVKDVTRRLGS-LK--------DGVDDVKQHKWFRGVDWDAVLMR-KSLPLI--- PKA-1_Smoe LVRRLLTADLTKRIGC-LK--------DGVDEIKNHSWFANVKWDNVLAK-KDTPPI--- PKA-2_Smoe LVRRLLTADLTKRIGC-LK--------DGVDEIKNHSWFANVKWDNVLAK-KDTPPI--- GK005_Glam LIIRLLNPDKTRRLGASIN--------NGTADIMKHAFFSGVNWSWFEKK-VVKAPI--- GK006_Glam LLKGLLEKKPRSRLGC-RKE------NGGIKELKGHPWFNGINWDKLYRK-EYTIPY--- PRKY_Hsap ------------------------------------------------------------ PRKX_Hsap -----------VPKI-AGD----------------------------------GDTSNFE PKACg_Hsap -----------IPKY-TGP----------------------------------GDASNFD PKACb_Hsap -----------IPKF-RGS----------------------------------GDTSNFD PKACa_Hsap -----------IPKF-KGP----------------------------------GDTSNFD Pka-C1_Dmel -----------IPRC-KGP----------------------------------GDTSNFD Pka-C2_Dmel -----------QPTI-SGA----------------------------------EDLSNFE CG12069_Dmel -----------VPNI-SNP----------------------------------EDISNFD PKA-C3_Dmel -----------LPDV-HHD----------------------------------GDTKNFD PRKX_Mmus -----------VPKL-SGD----------------------------------GDISNFE PKACb_Mmus -----------IPKF-RGS----------------------------------GDTSNFD PKACa_Mmus -----------IPKF-KGP----------------------------------GDTSNFD kin-1_Cele GESNGRLFEALYPRV-DGP----------------------------------ADTRHFV F47F2.1_Cele -----------VPTL-YHP----------------------------------GDTGNFD TPK1_Scer -----------EPPIQQGQ----------------------------------GDTSQFD TPK2_Scer -----------EPPITSGI----------------------------------GDTSLFD TPK3_Scer -----------EPPIQQGQ----------------------------------GDTSQFD DDB0185224_Ddis -----------STLN-SFINCDFNINLLKKSKSYTEQQQQQQQLPQQQQQQQQNN-QLFN pk4_Ddis -----------KPRI-RPL----------------------------------KH-HLMD PKA_Ddis -----------IPKI-QHQ----------------------------------GDSSNFE 17649_Tthe -----------TPQL-RNE----------------------------------QDASCFE 18333_Tthe -----------IPQL-KSI----------------------------------DDVSYFE 2171_Tthe -----------KPVV-KGK----------------------------------GDTSNYS 26485_Tthe -----------KPVV-KAP----------------------------------NDTSNFS PRKX_Spur -----------VPKL-SHA----------------------------------GDTSNFD PKA_Spur -----------VPRV-KGP----------------------------------GDASQFD CC1G_05183_Ccin -----------IPRT-TSV----------------------------------DDTRHFL CC1G_04466_Ccin -----------LPRI-SGD----------------------------------GDASAFD CC1G_01089_Ccin -----------LPKNP-SA----------------------------------SK-GMWH AqueK013_Aque ------------------------------------------------------------ AqueK014_Aque -----------VPKT-KGA----------------------------------GDPSNFD AqueK015_Aque -----------IPRV-SHP----------------------------------GDTRNFE PKA-1_Smoe -----------RPKV-AVC----------------------------------LY----- PKA-2_Smoe -----------RPKV-AVC----------------------------------VY----- GK005_Glam -----------VPKL-TDP----------------------------------ADTANYE GK006_Glam -----------KPTI-TDN----------------------------------LDLSNFD PRKY_Hsap ------------------------------------------------------------ PRKX_Hsap TY-PEN--DWD------TAA---------------------------------------- PKACg_Hsap DY-EEE--EL--------RI---------------------------------------- PKACb_Hsap DY-EEE--DI--------RV---------------------------------------- PKACa_Hsap DY-EEE--EI--------RV---------------------------------------- Pka-C1_Dmel DY-EEE--AL--------RI---------------------------------------- Pka-C2_Dmel NF-EFK--DRY------K------------------------------------------ CG12069_Dmel KV-SDK--PRP------K------------------------------------------ PKA-C3_Dmel DY-PEK--DWK------PAK---------------------------------------- PRKX_Mmus TY-PES--ELD------KTP---------------------------------------- PKACb_Mmus DY-EEE--EI--------RV---------------------------------------- PKACa_Mmus DY-EEE--EI--------RV---------------------------------------- kin-1_Cele EE-VQE--PTE------FVI---------------------------------------- F47F2.1_Cele DY-EED--TTG------GPL---------------------------------------- TPK1_Scer KY-PEE--DIN------YGV---------------------------------------- TPK2_Scer QY-PEE--QLD------YGI---------------------------------------- TPK3_Scer RY-PEE--EFN------YGI---------------------------------------- DDB0185224_Ddis QT-LQQ--Q-N------FNF-H----------PIQP-----QQQQQQQFFNFQFNNNNFN pk4_Ddis ER-DEE--D-R------ISA-N----------FIKP-----D------------------ PKA_Ddis MY-DEE--EMV------EEPPS-------------------S------------------ 17649_Tthe KY-PDS--QEG------A-R---------------------------------------- 18333_Tthe KY-PES--KDK------Q-E---------------------------------------- 2171_Tthe SY-PDS--TEL------PKP---------------------------------------- 26485_Tthe SY-PES--DTH------SPA---------------------------------------- PRKX_Spur EY-PEE--NWE------TDA---------------------S------------------ PKA_Spur EY-EEE--AL--------KI---------------------------------------- CC1G_05183_Ccin HL-PPP--TAE------EIPGL-------------VGQDLPQ------------------ CC1G_04466_Ccin KY-PED--NVQ------NTY-G-------------------L------------------ CC1G_01089_Ccin RQ-PLPNPQDVPGLKVVYPP-S-------------------H------------------ AqueK013_Aque ------------------------------------------------------------ AqueK014_Aque DY-KEE--VL--------RI---------------------------------------- AqueK015_Aque RY-P-------------------------------------------------------- PKA-1_Smoe ------------------------------------------------------------ PKA-2_Smoe ------------------------------------------------------------ GK005_Glam DY-LDE--NGN------FEE-DEIDYENLGSDAAELGLAEIP------------------ GK006_Glam KSFTEL--DFD------FSS-E-------PLYK--------R------------------ PRKY_Hsap ----------------------GR------------------------------------ PRKX_Hsap -------------PVPQKDLEIFK------------------------------------ PKACg_Hsap -------------SINEKCAKEFS------------------------------------ PKACb_Hsap -------------SITEKCAKEFG------------------------------------ PKACa_Hsap -------------SINEKCGKEFS------------------------------------ Pka-C1_Dmel -------------SSTEKCAKEFA------------------------------------ Pka-C2_Dmel -------------SRINRHPELFA------------------------------------ CG12069_Dmel -------------AKTMRHEEAFA------------------------------------ PKA-C3_Dmel -------------AVDQRDLQYFN------------------------------------ PRKX_Mmus -------------SVSDKDLETFK------------------------------------ PKACb_Mmus -------------SITEKCGKEFC------------------------------------ PKACa_Mmus -------------SINEKCGKEFT------------------------------------ kin-1_Cele -------------AATPQLEELFV------------------------------------ F47F2.1_Cele --------------CSQRDRDLFA------------------------------------ TPK1_Scer -------------QGEDPYADLFR------------------------------------ TPK2_Scer -------------QGDDPYAEYFQ------------------------------------ TPK3_Scer -------------QGEDPYMDLMK------------------------------------ DDB0185224_Ddis NNNNNNNNFNEACTSNTCGGTTAS------------------------------------ pk4_Ddis -------------LLERRKNEFFS------------------------------------ PKA_Ddis -------------NYVDPYAHLFK------------------------------------ 17649_Tthe -------------SLPRDLQHLFE------------------------------------ 18333_Tthe -------------NPTKEIQKLFA------------------------------------ 2171_Tthe ---------------IKPADDPFI------------------------------------ 26485_Tthe ---------------LKPADDPFL------------------------------------ PRKX_Spur -------------PVKSDVLKLFK------------------------------------ PKA_Spur -------------SLTEKCVKEFA------------------------------------ CC1G_05183_Ccin -------------PRFDPINYHFL------------------------------------ CC1G_04466_Ccin -------------PALDPYGVVFPDF---------------------------------- CC1G_01089_Ccin -------------ILHDNRFPPKL------------------------------------ AqueK013_Aque ------------------------------------------------------------ AqueK014_Aque -------------AAAEKFPKEFA------------------------------------ AqueK015_Aque -----------------------E------------------------------------ PKA-1_Smoe -----------------------F------------------------------------ PKA-2_Smoe -----------------------F------------------------------------ GK005_Glam -------------GTQEEIDALFV------------------------------------ GK006_Glam -------------EHNADDDQIFQDFCKAYATNAEDEQKTNCPTDNDESNTFTQSGQINY PRKY_Hsap --------------------------MM PRKX_Hsap --------------------------NF PKACg_Hsap --------------------------EF PKACb_Hsap --------------------------EF PKACa_Hsap --------------------------EF Pka-C1_Dmel --------------------------EF Pka-C2_Dmel --------------------------NF CG12069_Dmel --------------------------DF PKA-C3_Dmel --------------------------DF PRKX_Mmus --------------------------NF PKACb_Mmus --------------------------EF PKACa_Mmus --------------------------EF kin-1_Cele --------------------------EF F47F2.1_Cele --------------------------EW TPK1_Scer --------------------------DF TPK2_Scer --------------------------DF TPK3_Scer --------------------------EF DDB0185224_Ddis --------------------------IF pk4_Ddis --------------------------NF PKA_Ddis --------------------------DF 17649_Tthe --------------------------DF 18333_Tthe --------------------------DF 2171_Tthe --------------------------NW 26485_Tthe --------------------------DW PRKX_Spur --------------------------DF PKA_Spur --------------------------DF CC1G_05183_Ccin --------------------------EF CC1G_04466_Ccin -----------------------EYTGS CC1G_01089_Ccin --------------------------DL AqueK013_Aque ---------------------------K AqueK014_Aque --------------------------DF AqueK015_Aque --------------------------DG PKA-1_Smoe --------------------------LI PKA-2_Smoe --------------------------LI GK005_Glam -------------------------GFK GK006_Glam DSADAQDSTKGLPACLVDDDDTDMPPPP