CLUSTAL W (1.83) multiple sequence alignment PKD3_Hsap MSANNS--PPSA--QKSV-----LPTA-IPAVLPA------------------------- PKD2_Hsap MATAPSY--PA--------------------GLPGS------------------------ PKD1_Hsap MSAPPVLRPPSP--LLPVAAA--AAAA-AAALVPGS------------------------ CG7125_Dmel MEGP-------------------------------------------------------- PKD3_Mmus MSANNS--PPSA--QKSV-----FPAT-VSAVLPA------------------------- PKD2_Mmus MAAAPSH--PA--------------------GLPGS------------------------ PKD1_Mmus MSVPPLLRPPSP--LLPAAAA--VAAA-AAALVPGS------------------------ T25E12.4_Cele MDANDY--PRLYYTSMPSSSTSMVTTTRFSTSFSPSIPCHRQENFRRHSTSALAKRNGSE W09C5.5_Cele MDGSQG------------------------------------------------------ PKD_Spur MGEEL---PP-------------------------------------------------- AqueK080_Aque ------------------------------------------------------------ PKD3_Hsap ------------------------------------------------------------ PKD2_Hsap ------------------------------------------------------------ PKD1_Hsap ------------------------------------------------------------ CG7125_Dmel ------------------------------------------------------------ PKD3_Mmus ------------------------------------------------------------ PKD2_Mmus ------------------------------------------------------------ PKD1_Mmus ------------------------------------------------------------ T25E12.4_Cele SEKSAEIRENPDEIEVSRVSGRDSSLAFYTTAHETSSMLSRDSRDETLTPNEHIHQASSR W09C5.5_Cele ------------------------------------------------------------ PKD_Spur ------------------------------------------------------------ AqueK080_Aque ------------------------------------------------------------ PKD3_Hsap --------------------------------------------------ASPCSSPKTG PKD2_Hsap --------------------------------------------------PGPGSPPPPG PKD1_Hsap ---------------------------------------------------GPG------ CG7125_Dmel ------------------------------------------------------------ PKD3_Mmus --------------------------------------------------PSPCSSPKTG PKD2_Mmus --------------------------------------------------PGPGSPPPPG PKD1_Mmus ---------------------------------------------------GP------- T25E12.4_Cele RVSANDSVFEDGYVDFVDEPREHGSRRKSFEKFTDRNGEEKEGRVFELSTPQPTREAAPG W09C5.5_Cele ------------------------------------------------------------ PKD_Spur ------------------------------------------------------------ AqueK080_Aque ------------------------------------------------------------ PKD3_Hsap LSARLSNGSFSAPSLTNSR----------------------------GSVHTVSFLLQIG PKD2_Hsap GL-EL---QSPPPLLPQIP----------------------------APGSGVSFHIQIG PKD1_Hsap ----------PAPFLAPVA----------------------------APVGGISFHLQIG CG7125_Dmel ---------------------------------------------------EVTFLFQFG PKD3_Mmus LSARLSNGSFSAPSLTNSR----------------------------GSVHTVSFLLQIG PKD2_Mmus GL-DL---QSPPPLLPQIP----------------------------APGSGVSFHIQIG PKD1_Mmus -----------APFPAPGA----------------------------APAGGISFHLQIG T25E12.4_Cele AH-QF---QLPTLLVTSTPTTVFDHSDDEVWTPYRPPPNREYSSSSEPMMGDLTFRLQSG W09C5.5_Cele -----------------------------------------------STDYGDHVVLRYG PKD_Spur -----------LPPM-TRP----------------------------GLVHGVSFAVQIG AqueK080_Aque ------------------------------------------------------------ PKD3_Hsap LTRESVTIEAQ---ELSLSAVKDLVCSIVYQKFPECGFFGMYD-KILLFRHDMNSENILQ PKD2_Hsap LTREFVLLPAAS----ELAHVKQLACSIVDQKFPECGFYGLYD-KILLFKHDPTSANLLQ PKD1_Hsap LSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYD-KILLFRHDPTSENILQ CG7125_Dmel SVRDAVCVPAN---SLTLKTLKDLACDFINTKIPDSGLTYLSE-RILLFVHDYSTPNVLH PKD3_Mmus LTRESVTIEAQ---ELSLSAVKDLVCSIVYQKFPECGFFGMYD-KILLFRHDMNSENILQ PKD2_Mmus LTREFVLLPAAS----ELAHVKQLACSIVDQKFPECGFYGLYD-KILLFKHDPTSANLLQ PKD1_Mmus LSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGLYD-KILLFRHDPASDNILQ T25E12.4_Cele IHKKSIAVEGT---EIALRDLRNEALQFIKEIYPEKGCSSLED-YILLYKHDLRSINILQ W09C5.5_Cele GTREMVPLIRH---EQMLDMLMERARQIV------QGFGNLDTRNMYLFRHEYNSPTLLY PKD_Spur FVRENFQIPPE-GGDPSIPLIKEIVTSMVRQRFPEHDFYGVYD-KLLLFKHNPGTSYSLT AqueK080_Aque ------------------------------------------------------------ PKD3_Hsap LITSADEIHEGDLVEVVLSA---------------------------------------- PKD2_Hsap LVRSSGDIQEGDLVEVVLSA---------------------------------------- PKD1_Hsap LVKAASDIQEGDLIEVVLSA---------------------------------------- CG7125_Dmel IINSAAEVVDETLVEIVLTA---------------------------------------- PKD3_Mmus LITSADEIHEGDLVEVVLSA---------------------------------------- PKD2_Mmus LVRSAADIQEGDLVEVVLSA---------------------------------------- PKD1_Mmus LVKIASDIQEGDLIEVVLSA---------------------------------------- T25E12.4_Cele LITTSSDVTDGTLVEVVIGS---------------------------------------- W09C5.5_Cele PITSASQITSGSILEIILVD---------------------------------------- PKD_Spur PVTSVSDVTEGALIEAVLSDQWDGSRMNDLVSQNPSSGKYIYLVKKYDFYCRLLTSLFFS AqueK080_Aque ------------------------------------------------------------ PKD3_Hsap --------------LA----TVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKC PKD2_Hsap --------------SA----TFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKC PKD1_Hsap --------------SA----TFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKC CG7125_Dmel --------------SPILYPTSEMPTLKPHSLNVHSYKGPTFCDFCGEMLFGLVRQGLKC PKD3_Mmus --------------LA----TVEDFQIRPHALYVHSYKAPTFCDYCGEMLWGLVRQGLKC PKD2_Mmus --------------SA----TFEDFQIRPHALTVHSYRAPAFCDHCGEMLFGLVRQGLKC PKD1_Mmus --------------SA----TFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKC T25E12.4_Cele --------------CP----QNERIVVHPHTLFVHSYKVPTFCDFCGELLFGLVKQGLKC W09C5.5_Cele --------------R-------TEAAVIPHVVEPESYMRPTFCDFCGEMLTGLMRQGVKC PKD_Spur TIMNSNAGLQFCFSSA----TVEDRQIRPHTLYVHSYKSPTFCDFCGQMLFGLVRQGLKC AqueK080_Aque ------------------------------------------------------------ PKD3_Hsap EGCGLNYHKRCAFKIPNNCSGVRKRRL-SNVSLPGPGLSV---------PR-------PL PKD2_Hsap DGCGLNYHKRCAFSIPNNCSGARKRRL-SSTSLASGH-SVRLGTSESLPCTAEE-LSRST PKD1_Hsap EGCGLNYHKRCAFKIPNNCSGVRRRRL-SNVSLTGVS-TIRTSSAELSTSAPDEPLLSPV CG7125_Dmel DGCGQNYHKRCVVKIPNNCNRSNDATSRRSFTLQAPR-SPSGSSQQSLVSTEDST-GR-- PKD3_Mmus EGCGLNYHKRCAFKIPNNCSGVRKRRL-SNVSLPGPGLSV---------PR-------PL PKD2_Mmus DGCGLNYHKRCAFSIPNNCSGARKRRL-SSTSLASGH-SVRLGSSESLPCTAEE-LSRST PKD1_Mmus EGCGLNYHKRCAFKIPNNCSGVRRRRL-SNVSLTGLG-TVRTASAEFSTSVPDEPLLSPV T25E12.4_Cele FGCGLNYHKRCASKIPNNCNGSKQRRP-SAIPLSPSN-SNILNLNERRHSRRES-C---- W09C5.5_Cele KNCNGNFHKRCSNAARNNCGAPGAPGAQ------------------------------PS PKD_Spur DGCGGNYHKRCAFKIPNDCTLSKRRRS--SLAISS--SSIPWSPSETSLSSEDSQ-QQQQ AqueK080_Aque ------------------------------------------------------------ PKD3_Hsap QP-----EYVALPSEES-----------------------HVHQEPSKRIPSWSGRPIWM PKD2_Hsap TE-----LLPRRPPSSS----------------------------SSSSASSYTGRPIEL PKD1_Hsap SP-----GFEQKSPSES-----------------------FIGREKRSNSQSYIGRPIHL CG7125_Dmel ---------NDSSSSLN-----------------------IPGRHQRTHSS--G------ PKD3_Mmus QP-----ECVPLLSEES-----------------------HTHQEPSKRIPSWSGRPIWM PKD2_Mmus TD-----LLPRRPPSSS---------------------------SSSSSSSFYTGRPIEL PKD1_Mmus SP-----GFEQKSPSES-----------------------FIGREKRSNSQSYIGRPIQL T25E12.4_Cele LE-----ALDAARPSSTLGGAATPNIFITSDDCGDAVGGNYLQMPRKDRSCSWSGRPLWM W09C5.5_Cele RP-----PILPPIP------------------------------------TTPTGFPV-- PKD_Spur QQLAVFVTHSQQTPLVK------------------------SDSYKERRSPSWGNRPLWV AqueK080_Aque ------------------------------------------------------------ PKD3_Hsap EKMVMCR--VKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVP PKD2_Hsap DKMLLSK--VKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVP PKD1_Hsap DKILMSK--VKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVP CG7125_Dmel SRNGLMV--LRIPHTFMVHTYGIPTVCQLCKKLLKGLFKQGLQCRDCQYNTHKKCMDKVP PKD3_Mmus EKMVMCR--VKVPHTFAVHSYGRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVP PKD2_Mmus DKMLMSK--VKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVP PKD1_Mmus DKLLMSK--VKVPHTFVIHSYTRPTVCQFCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVP T25E12.4_Cele EIAEATRVKLQVPHTFQVHSYKLPTVCQHCKKLLKGLIRQGMQCRDCKYNCHKKCSEHVA W09C5.5_Cele -AALSTP--TGLPHTLIEHSYRQFTVCKVCDHLLVGLVKQGLKCRDCGVNVHRKCAMELA PKD_Spur ERAVASR--IKVPHTFVVHNYTKPTICQYCKRLLVGLFRQGLQCKDCKFNCHKRCADKVP AqueK080_Aque ------------------------------------------------------------ PKD3_Hsap RDCLG-EVTFNGEPSSLGT-DTDIPMDIDNNDINSDS-SR----G-LDDTEEPSPPEDKM PKD2_Hsap NDCLG-EALING----------DVPMEEATDFSEADK-SA-----LMDESEDSGVIPGS- PKD1_Hsap NNCLG-EVTINGDLLSPGA-ESDVVMEEGSDDNDSER-NS----GLMDDMEEAMVQDAEM CG7125_Dmel HDCTG-EAQLSQLQIQAGAKERDNFFREEFDDSDGDD-GSEEAPKALTNAHNSPPELVNG PKD3_Mmus RDCLG-EVTFNGEPCSVGT-DADMPMDIDSSDVNSDG-SR----G-LDDSEEPSPPEDKM PKD2_Mmus NDCLG-EALING----------DVPMEEAADYSEADK-SS-----ISDELEDSGVIPGS- PKD1_Mmus NNCLG-EVTINGELLSPGA-ESDVVMEEGSDDNDSER-NS----GLMDDMDEAMVQDTEM T25E12.4_Cele KDCSG-NTKASQFF--LGS-QADDGASEDRDDDLSLRSGS----GAHKKAQN-T----PS W09C5.5_Cele SNCVLSENAISR------------------------------------------------ PKD_Spur KDCLG-ETPLQE-----GD-NDDQERLIESDENEAEE-NE----------------NGS- AqueK080_Aque ------------------------------------------------------------ PKD3_Hsap F------------FLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMV PKD2_Hsap --------------HSENALHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTL PKD1_Hsap AMAECQN---D--SGEMQDP-DPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVM CG7125_Dmel GLVDDSS--VSGGETSKSSS-DGQSEQSQSSTSSSPSANIPLMRIVQSVKHTKKRGGQAL PKD3_Mmus F------------FLDPTDLDVERDEETVKTISPSTSNNIPLMRVVQSIKHTKRRSSTVV PKD2_Mmus --------------HSESALHASEEEEGEGHKAQSSLGYIPLMRVVQSVRHTTRKSSTTL PKD1_Mmus ALAEGQS---G--GAEMQDP-DADQEDSNRTISPSTSNNIPLMRVVQSVKHTKRRSSTVM T25E12.4_Cele APLQGSEGSGSPGPVVSFAANA-LSNMPDDDVISSESANIPLMRVVMSKKQTKRKNNKLL W09C5.5_Cele ----------------------VNFTDPEG-PGSSSSDNIPLFRLPGQVG--TRATEKKK PKD_Spur -NRD------S--IGDETL---PDSPVNENPLSPVQSNNIPLMRIVQSVKHTKRRGSQVL AqueK080_Aque ------------------------------------------------------------ PKD3_Hsap KEGWMVHYTSRDNL-RKRHYWRLDSKCLTLFQNES------GSKYYKEIPLSEILRISSP PKD2_Hsap REGWVVHYSNKDTL-RKRHYWRLDCKCITLFQNNT------TNRYYKEIPLSEILTVESA PKD1_Hsap KEGWMVHYTSKDTL-RKRHYWRLDSKCITLFQNDT------GSRYYKEIPLSEILSLEPV CG7125_Dmel KEGWLVHYTSLDKA-VKRYYWRLDSKTITLFVSEQ------GSKYHKELPLAELLSIESH PKD3_Mmus KEGWMVHYTSRDNL-RKRHYWRLDSKCLTLFQNES------GSKYYKEIPLSEILRVSSP PKD2_Mmus REGWVVHYSNKDTL-RKRHYWRLDCKCITLFQNNT------TNRYYKEIPLSEILAVEPA PKD1_Mmus KEGWMVHYTSKDTL-RKRHYWRLDSKCITLFQNDT------GSRYYKEIPLSEILCLEPA T25E12.4_Cele KEGWIVHYTDQQNM-RKKHYWRLDTKGITMYQDEN------TTRYYKEIPLNEILNVSMS W09C5.5_Cele LEGWMMHFILSDPERRLKHYWMMQSNAIHLYNEYSEGIGVNPNRVYRIIPLAEITSVVQN PKD_Spur KEGWMVHYTDKDSM-RKRHYWRIDTKAITLYQSES------STRYYKEIPLSEILSVRMV AqueK080_Aque ---------------RKKHFWRLDTKTLTLYKDSE------SSHYYKEIQLADIMAVDPM :::* :: : : :: . .: :: : * :: : PKD3_Hsap RDFTNIS------------------QGSNPHCFEIITD-TMVYFVGENNGDSSHNP---- PKD2_Hsap QNFSLVP------------------PGTNPHCFEIVTA-NATYFVGEMPGGTPG------ PKD1_Hsap KTSALIP------------------NGANPHCFEITTA-NVVYYVGENVVNPSSPSPN-- CG7125_Dmel LG---DP------------------RPECNYCFELRLP-NLSYFVGQDPQVGAKEEQA-- PKD3_Mmus QDFTSIS------------------QGSNPHCFEIITD-TVVYFVGENNGSSSHNP---- PKD2_Mmus QNFSLVP------------------PGTNPHCFEIITA-NVTYFVGETPGGAPG------ PKD1_Mmus KPSALTP------------------VGATPHCFEITTA-NVVYYVGENVVNPSSSPPN-- T25E12.4_Cele P-----P------------------DKTADYLFEIRTG-VCVYFISGSPSD--------- W09C5.5_Cele NGKSV-L------------------AKHPPHCFEIRTTTNTVFCVGEDYHAFSGGPPK-- PKD_Spur KPSQDGSGSGSSSSGMGISGLVGGDGFNSTHCFEIQTA-KTNYYVGERASLGDSSSEKGS AqueK080_Aque VNHALYP-------------------LSPPHVFEIVTS-SCTYYVGVDMAGAVPEDLNPP : **: : :. PKD3_Hsap -----------------------VL-AATGVGLDVAQSWEKAIRQALMPVTPQASVCTSP PKD2_Hsap --------------------------GPSGQGAEAARGWETAIRQALMPVILQDAP-SAP PKD1_Hsap ----------------------NSV-LTSGVGADVARMWEIAIQHALMPVIPKGSS-VGT CG7125_Dmel --------------------VRLPP-PDSGIGSDIAKSWETSIRQAFMHVTNTQC----- PKD3_Mmus -----------------------VL-AATGVGLDVAQSWEKAIRQALMPVTPQASVCTSP PKD2_Mmus --------------------------GPSGQGTEAVRGWETAIRQALMPVILQDAP-SAP PKD1_Mmus ----------------------NSV-LPSGIGPDVARMWEVAIQHALMPVIPKGSS-VGS T25E12.4_Cele ---------------------------EKGSSLD-AQSWTTAIQSALMPVTPQSSVV-GG W09C5.5_Cele ----------------------KIPRSMSVRPSSNTTMWFQFIKESLQPPSR-------- PKD_Spur G---GSTTSSSKLPVPSSSSVDEEP-EQSWVGADVARDWEQKIRQALMPVTPQQSGTSIT AqueK080_Aque KQTEGALG--PNILCNVSHMSLNQL-EEIGVGLTVALSWEEGLHSALMPITPQASMGSLA . * :: :: PKD3_Hsap GQG------------KDHKD---------------------------------------- PKD2_Hsap GH-------------APHRQ---------------------------------------- PKD1_Hsap GT-------------NLHRD---------------------------------------- CG7125_Dmel ------------------------------------------------------------ PKD3_Mmus GQG------------KDHKD---------------------------------------- PKD2_Mmus GH-------------TPHRQ---------------------------------------- PKD1_Mmus GS-------------NSHKD---------------------------------------- T25E12.4_Cele -KR------------IDKLK---------------------------------------- W09C5.5_Cele ------------------------------------------------------------ PKD_Spur STS------------SPRNDSVIQIP-RG---------YNPHHRQERKEGPVNATENGDD AqueK080_Aque DIGVPGAAIVRPSSFRGRRGSSLKGSFRGTKGSFRNASRPPHHTSTGRGSFRGSFRAVKQ PKD3_Hsap LSTSIS---VSNCQIQEN-VDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVID PKD2_Hsap ASLSIS---VSNSQIQEN-VDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVID PKD1_Hsap ISVSIS---VSNCQIQEN-VDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIID CG7125_Dmel ------------CESEEQVQDMGQLYQIFPDEVLGSGQFGVVYGGVHKKTQREVAIKVID PKD3_Mmus LATSIS---VSNCQVQEN-VDISSVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVID PKD2_Mmus ASLSIS---VSNSQIQEN-VDIATVYQIFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVID PKD1_Mmus ISVSIS---VSNCQIQEN-VDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIID T25E12.4_Cele VPTEGE-TGHLGAKIQTE-HEFSQLYQIFAEEVLGSGQFGTVYGGIHRRNGQHVAVKLID W09C5.5_Cele ----------NEDNAEQA-LEFANLYQVLSDKTLGSGQFGTVYSAIQRHSGKEVAVKVIS PKD_Spur FPAKVS--EPSFLNKREN-NDISQHYQIFPDEILGSGQFGIVYGGVHRTSGRQVAIKVID AqueK080_Aque SPPAIPVRAAMKPKIETK-MDVSQMYQIFPEEILGSGQFGTVFGGQNRTTGKSVAIKVID : . :.. **::.:: ******* *:.. :: . : **:*:*. PKD3_Hsap KMRFPTKQE--SQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSS PKD2_Hsap KLRFPTKQE--SQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSS PKD1_Hsap KLRFPTKQE--SQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSS CG7125_Dmel KLRFPTKQE--AQLKNEVAILQNISHCGVVNLERMFETPERIFVVMEKLKGDMLEMILSH PKD3_Mmus KMRFPTKQE--SQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSS PKD2_Mmus KLRFPTKQE--SQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSS PKD1_Mmus KLRFPTKQE--SQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSS T25E12.4_Cele KLKFPPNKE--DLLRAEVQILEKVDHPGVVHFMQMLETTDRIFVVMEKLKGDMLEMILSS W09C5.5_Cele KERFSKKGSGAESMRAEVAILQQTCHPGIVCLEFMCETKDKIFVVMEKMNGDMLEMILSQ PKD_Spur KFRFPTKQE--TQLKNEVAILHKVRHPGVVNLEQMFETPERVFVVMEKLKGDMLEMILSS AqueK080_Aque KLRFPHKQD--TALRQEVTILQFLDHPGIIYLEQMFETPEKIYIAMEKMNGDMLEMILSS * :*. : . :: ** **. * *:: : * ** :::::.***::********* PKD3_Hsap EKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLAS-AEPFPQVKLCDFGFAR PKD2_Hsap EKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLAS-ADPFPQVKLCDFGFAR PKD1_Hsap EKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLAS-ADPFPQVKLCDFGFAR CG7125_Dmel ARGRLSERVTKFLITQILIALKYLHSQNIVHCDLKPENVLLSS-DAEFPQVKLCDFGYAR PKD3_Mmus EKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLAS-AEPFPQVKLCDFGFAR PKD2_Mmus EKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLAS-ADPFPQVKLCDFGFAR PKD1_Mmus EKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLAS-ADPFPQVKLCDFGFAR T25E12.4_Cele EKGRLSERTTQFLVAQILEALRYLHHLNIVHCDLKPENILLNS-NSDFPQVKLCDFGFAR W09C5.5_Cele ELGRLNSRATKFLLVQILCALKYLHDQGIAHCDLKPENVLLSDMGSNFPQTKICDFGYAR PKD_Spur VHGRLFERVTRFLISQILIALKYLHSKSIVHCDLKPENVLLSS-DGDFPQVKLCDFGFAR AqueK080_Aque PNSRLSERVTKFLVYQILAALQYLHKKDIVHCDLKPENVLLTS-ESGMPQVKLCDFGFAR .** .: *:*:: *** **: ** .*.********:** . :**.*:****:** PKD3_Hsap IIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQ PKD2_Hsap IIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQ PKD1_Hsap IIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQ CG7125_Dmel IIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEEEDINDQ PKD3_Mmus IIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIVYVSLSGTFPFNEDEDINDQ PKD2_Mmus IIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSGTFPFNEDEDINDQ PKD1_Mmus IIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQ T25E12.4_Cele IIGEKSFRRSVVGTPAYLAPEVLRNKGFNRSLDMWSVGVIVYVSLSGTFPFNEDEDINDQ W09C5.5_Cele FIPESQFRKTVVGTPAYLPPEVLQRKGYNKSLDMWSVGVIIYVTLSGTFPFNEGEEISEQ PKD_Spur IIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIVYVSLSGTFPFNEDEEITDQ AqueK080_Aque IIGEKSFRKSIVGTPAYLAPEVLKNEGYNRSLDLWSVGVIIYVSLSGTFPFNEDEEISDQ :* *..**:::*******.**** :*:*:***:******:**:********* *:* :* PKD3_Hsap IQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFE PKD2_Hsap IQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELE PKD1_Hsap IQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELE CG7125_Dmel IQNAAFMYPPNPWKEISSNAIDLINNLLQVKQRKRYTVDKSLLHYWLQDKQTYRDLRNLE PKD3_Mmus IQNAAFMYPPNPWREISSEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFE PKD2_Mmus IQNAAFMYPASPWSHISSGAIDLINNLLQVKMRKRYSVDKSLSHPWLQEYQTWLDLRELE PKD1_Mmus IQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELE T25E12.4_Cele IQNAEFMYPPTPWKEISENAIEFINGLLQVKMSKRYTVTKAQSQIWMQNYTLWSDLRVLE W09C5.5_Cele IQNASFMFPTEPWSEVEPLAVDLIQKLLKVEIEARMSIEQCLDHGWLKGEQLYRDLRDLE PKD_Spur IHNAAFMFPPNPWNEISEGAIDLIRNLLQVKIRKRYTADKSLAHPWLQDYQVWLDLRDLE AqueK080_Aque IHNAAFMYPPDPWAAITQEAIDLVSKLLQINRRSRFKTTQALNHIWLRDIRLYEDVCELE *:** **:*. ** : *:::: **::: * . : : *:: : *: :* PKD3_Hsap TRIGE-RYITHESDDARWEIHAYT-HNLV----YPK------------------------ PKD2_Hsap GKMGE-RYITHESDDVRWEQFAAE-HPLP----G-------------------------- PKD1_Hsap CKIGE-RYITHESDDLRWEKYAGE-QGLQ----YPT------------------------ CG7125_Dmel AQVGAGRYLTHEADDLRW------------------------------------------ PKD3_Mmus TRIGE-RYITHESDDARWEIHAYT-HNLE----YPK------------------------ PKD2_Mmus GKMGE-RYITHESDDARWDQFVAE-RH--------------------------------- PKD1_Mmus CRIGE-RYITHESDDSRWEQYAGE-QGLQ----YPA------------------------ T25E12.4_Cele KAVGQ-RFVTHESDDQQDPQRNFS-YFLHLLVTYPFKFYF---VFSCFII-FF------- W09C5.5_Cele VRLNTPRYLTSPQDDILYGTLV-------------------------------------- PKD_Spur TIVGS-RYLTHESDDERWSAYQQA-QLGA------------------------------- AqueK080_Aque GRLDI-RYLTHETEDAWWAQQGAKPHPLV----LKKEKKFSHHVYKNIQILDDPHRSNVP :. *::* :* PKD3_Hsap -----------------------HFI--M---------APNPDDM--------------- PKD2_Hsap -----------------------SGL--P--TDRDLGGACPPQDHD-------------- PKD1_Hsap -----------------------HLI--N--PSASHSDTPETEETE-------------- CG7125_Dmel ------------------------------------------------------------ PKD3_Mmus -----------------------HFI--M---------APNPDDM--------------- PKD2_Mmus ------------------------GT--P--AEGDLGGACLPQDHE-------------- PKD1_Mmus -----------------------HLI--S--LSASHSDSPEAEERE-------------- T25E12.4_Cele ---------------------------PN--FLTHIPCVP-------------------- W09C5.5_Cele ------------------------------------------------------------ PKD_Spur -------------------------G--N--DPAPGGNSPDNNSTH-------------- AqueK080_Aque SIATTVAVAKPPPPPSSNPPPSSTLVNPGPPAPTNNRSSKDKDSTDLKAGRKEKEGVAIK PKD3_Hsap --------------EEDP PKD2_Hsap ---MQ----GLAERISVL PKD1_Hsap ---MK----ALGERVSIL CG7125_Dmel -----------------D PKD3_Mmus --------------EEDP PKD2_Mmus ---MQ----GLAERISIL PKD1_Mmus ---MK----ALSERVSIL T25E12.4_Cele --------------TPIS W09C5.5_Cele ----------------NP PKD_Spur ---LQLSPVRHMDRVSTL AqueK080_Aque LSDIEAHAKRVGYTVSTV