CLUSTAL W (1.83) multiple sequence alignment PKG2_Hsap MGNGSVKP------------------------------------------KHSKHPDGHS PKG1_Hsap MGTLR------------------------------------------------------- for_Dmel MKIKHYPG---------------------------------------------K------ CG4839_Dmel MACFPRLFHNR--------------------------------SKNKFTPAEDENTDTIL Pkg21D_Dmel MAAGMLTD------------------------------------------RER---EAIV PKG2_Mmus MGNGSVKP------------------------------------------KHAKHPDGHS PKG1_Mmus MGTLR------------------------------------------------------- egl-4_Cele MSSGSRPS--SGGGGGGGGASGGAGGGAPGGGGGGIRGFFSKLR------KPSDQPNGNQ C09G4.2_Cele MDFTR------------------------------------------------------- PKG2_Spur MLCL-------------------------------------------------------- PKG1_Spur MKW--------------------------------------------------------- AqueK021_Aque MSANNEQK---------------------------------------------------- PKG_Smoe ------------------------------------------------------------ PKG2_Hsap ---GNLT--TDALRN-------------KV-TE---L------ER--------------- PKG1_Hsap --------------------------------D---L------QY--------------- for_Dmel ------------AVDASLSLEGSSAMG-AL-YE---A------NWLRAANQPAAPATTGT CG4839_Dmel ---NTQDSNVQ--------------IGKYIRREEKPLYSPIVTPS--------------- Pkg21D_Dmel ---SNLTKDVQALRE--------------------------------------------- PKG2_Mmus ---GNLS--NEALRS-------------KV-LE---L------ER--------------- PKG1_Mmus --------------------------------D---L------QY--------------- egl-4_Cele VQVGTRTFEAHELQK-------------LI-PQ---L------EE--------------- C09G4.2_Cele ------------------------------------------------------------ PKG2_Spur ------------------------------------------------------------ PKG1_Spur ------------------------------------------------------------ AqueK021_Aque ------------LRD-------------LL-LQ---R------AM--------------- PKG_Smoe ------------------------------------------------------------ PKG2_Hsap ------------ELRRKDAEIQERE----------------------------------- PKG1_Hsap ------------ALQEKIEELRQRD----------------------------------- for_Dmel KLSRQSSSAGSSFLIEGISALSKYQ----------------------------------- CG4839_Dmel ------------ASEAKLQRLRQQQQPPGSPPAPARWTLHSVAENGSANNGVQERKFRTN Pkg21D_Dmel -------------------MVRSRE----------------------------------- PKG2_Mmus ------------ELRRKDAELQERE----------------------------------- PKG1_Mmus ------------ALQEKIEELRQRD----------------------------------- egl-4_Cele ------------AISRKDAQLRQQQ----------------------------------- C09G4.2_Cele ------------------------E----------------------------------- PKG2_Spur ------------------------------------------------------------ PKG1_Spur ------------------------------------------------------------ AqueK021_Aque ------------ELQKFKSDLERVT----------------------------------- PKG_Smoe ------------------------------------------------------------ PKG2_Hsap ------------------------------------------------------------ PKG1_Hsap ------------------------------------------------------------ for_Dmel ------------------------------------------------------------ CG4839_Dmel KDKLQAQDACPSGGSAINVIRSSSKLKPVKERRPTALPTEVPSIEIEDVRDAKDTGDGMD Pkg21D_Dmel ------------------------------------------------------------ PKG2_Mmus ------------------------------------------------------------ PKG1_Mmus ------------------------------------------------------------ egl-4_Cele ------------------------------------------------------------ C09G4.2_Cele ------------------------------------------------------------ PKG2_Spur ------------------------------------------------------------ PKG1_Spur ------------------------------------------------------------ AqueK021_Aque ------------------------------------------------------------ PKG_Smoe ------------------------------------------------------------ PKG2_Hsap ------------------------------YHLKE------------------------- PKG1_Hsap ------------------------------ALIDE------------------------- for_Dmel ------------------------------MTLENI------------------------ CG4839_Dmel SLGERVQPGANAHVDVVDGGGKSKLKVNVNGIIDESVAHDDDYDTPSSNSIATTPVTEGP Pkg21D_Dmel ------------------------------------------------------------ PKG2_Mmus ------------------------------YHLKE------------------------- PKG1_Mmus ------------------------------ALIDE------------------------- egl-4_Cele ------------------------------TIVEG------------------------- C09G4.2_Cele ------------------------------ALLA-------------------------- PKG2_Spur ------------------------------------------------------------ PKG1_Spur ------------------------------------------------------------ AqueK021_Aque ------------------------------KINKE------------------------- PKG_Smoe ------------------------------------------------------------ PKG2_Hsap --------LREQLSKQTVA--------------------IAELT--E------------- PKG1_Hsap --------LELELDQKDEL--------------------IQKLQ--N------------- for_Dmel --------RQLELQSRDKR--------------------IASTI--K------------- CG4839_Dmel VKFFIGHTQELSAQQTDDTLSCQSSDANNNSAAKLTNGVVPQEQPEREMGKQQALQAPPR Pkg21D_Dmel -----------------SE--------------------LVKLH--R------------- PKG2_Mmus --------LREQLAKQTVA--------------------IAELT--E------------- PKG1_Mmus --------LELELDQKDEL--------------------IQKLQ--N------------- egl-4_Cele --------HIKRISELEGE--------------------VTTLQ--R------------- C09G4.2_Cele -----------ELELKDDI--------------------IEQLR--K------------- PKG2_Spur ------------------------------------------------------------ PKG1_Spur ------------------------------------------------------------ AqueK021_Aque --------QQNEIAAKNEQ--------------------ISTLE--G------------- PKG_Smoe ------------------------------------------------------------ PKG2_Hsap --------------------------------------------------ELQNKCIQLN PKG1_Hsap --------------------------------------------------ELDKYRSVIR for_Dmel --------------------------------------------------ELSGYRPSAL CG4839_Dmel AKSSSNVSLNYLAKSQTDSQRRRRVSTMPDINIPPAPPLPPELLVPGTPLHLRKKRSMER Pkg21D_Dmel --------------------------------------------------EIHKLKSVLQ PKG2_Mmus --------------------------------------------------ELQSKCIQLN PKG1_Mmus --------------------------------------------------ELDKYRSVIR egl-4_Cele --------------------------------------------------ECDKLRSVLE C09G4.2_Cele --------------------------------------------------ELDEYRMM-- PKG2_Spur ------------------------------------------------------------ PKG1_Spur ------------------------------------------------------------ AqueK021_Aque --------------------------------------------------ELKKKQKELE PKG_Smoe ------------------------------------------------------------ PKG2_Hsap KL---------------------------------------------------------- PKG1_Hsap PA---------------------------------------------------------- for_Dmel QH--------------HQQQQMHNVWVAEDQDQEHEELEDASEGKEKLASIQEPPAVNHY CG4839_Dmel QQQ--------------------------------------------------------- Pkg21D_Dmel QTTNNLNVTRNEKAKKK------------------------------LYSLPEQCGEQES PKG2_Mmus KL---------------------------------------------------------- PKG1_Mmus PA---------------------------------------------------------- egl-4_Cele QK---------------------------------------------------------- C09G4.2_Cele ------------------------------------------------------------ PKG2_Spur ------------------------------------------------------------ PKG1_Spur ------------------------------------------------------------ AqueK021_Aque IQ---------------------------------------------------------- PKG_Smoe ------------------------------------------------------------ PKG2_Hsap -------------------------------QDVVHMQGGSPLQASPDK----------- PKG1_Hsap -------------------------------TQQAQKQSASTLQG--------------- for_Dmel VLDPTERPRVPRPRQQFSVKPPSLRRS----QTMSQPPSYATLRSPPKIKENLSKSSSAY CG4839_Dmel --------------------------------QKQQE----------------------- Pkg21D_Dmel RNQNPHLCSSCGMVLPTSPEFALEALSLGPLSPLASTSSASPS-----G----------- PKG2_Mmus -------------------------------QDVIHVQGGSPLQASPDK----------- PKG1_Mmus -------------------------------TQQAQKQSASTLQG--------------- egl-4_Cele -------------------------------AQSAASPGGQPPSPSPRT----------- C09G4.2_Cele ------------------------------------------------------------ PKG2_Spur ------------------------------------------------------------ PKG1_Spur ------------------------------------------------------------ AqueK021_Aque -------------------------------KQRV-----TELT---------------- PKG_Smoe ------------------------------------------------------------ PKG2_Hsap ----V--PLE--------------VHR-KTSGLV---SLHSRRG-AKAGVSAEPTTRTYD PKG1_Hsap ----------------------------------------EPRT-KRQAISAEPTAFDI- for_Dmel STFSS--AAEDSQDQVVICQQPQRLMAPPPREPP---PE-PPKRVSKPLSRSQT---SV- CG4839_Dmel ----QQQQQE--------------IQQ--DATNSQDQMAGAEES-HKSSDSSTPKTHRVE Pkg21D_Dmel ----RTSADE--------------V---RPKA-------MPAAI-KKQGVSAESCVQSM- PKG2_Mmus ----V--PLD--------------VHR-KTSGLV---SLHSRRG-AKAGVSAEPTTRTYD PKG1_Mmus ----------------------------------------EPRT-KRQAISAEPTAFDI- egl-4_Cele ----DQLGND--------------LQQ-K-AVLP---ADGVQRA-KKIAVSAEPTNF--E C09G4.2_Cele -----------------------------------------NTT-RKTAISSEPDI---- PKG2_Spur ------------------------------------------------------------ PKG1_Spur ------------------------------------------------------------ AqueK021_Aque ----E--IMD--------------RQV-RDKS--------RPVE-HRQGISAEPTKA-L- PKG_Smoe ------------------------------------------------------------ PKG2_Hsap -------LNKPPEFSFEKARVRKDSS------------EKK------------------- PKG1_Hsap --------QDL--SHVTLPFYPKSPQ------------SKD------------------- for_Dmel --------QRY--ATVRMPNQTTSFSRSVVRSRDSTASQRRLSLEQAIEGLKLEGEKAVR CG4839_Dmel GGLIYVRPNFPIQSDIEIESIAKDEG------------TRN------------------- Pkg21D_Dmel --------QQS--YSIPIPKYEKDFS------------DKQ------------------- PKG2_Mmus -------LNKPPEFSFEKARVRKDSS------------EKK------------------- PKG1_Mmus --------QDL--SHVTLPFYPKSPQ------------SKD------------------- egl-4_Cele -------N-----KPATLQHYNKTVG------------AKQ------------------- C09G4.2_Cele --------------QVKRPIIGKSDA------------AFE------------------- PKG2_Spur -----------------------GIV------------SKQ------------------- PKG1_Spur ------------------------------------------------------------ AqueK021_Aque -------------KITQLPRYEKDQR------------SKE------------------- PKG_Smoe ------------------------------------------------------------ PKG2_Hsap ----LITDALNKNQFLKRLDPQQ-----IKD-MVE-CMYGRNYQQGS------------- PKG1_Hsap ----LIKEAILDNDFMKNLELSQ-----IQE-IVD-CMYPVEYGKDS------------- for_Dmel QKSPQISPAASSNGSSKDLNGEGFCIPRPRL-IVPVHTYARRRRTGNLKEQSSGGQEEEA CG4839_Dmel ----LIRTAIERNDFLNNLMDKE-----RKEMVIN-AMAPASYRKHS------------- Pkg21D_Dmel ----QIKDAIMDNDFLKNIDASQ-----VRE-LVD-SMYSKSIAAGE------------- PKG2_Mmus ----LITDALNKNQFLKRLDPQQ-----IKD-MVE-CMYGRNYQQGS------------- PKG1_Mmus ----LIKEAILDNDFMKNLELSQ-----IQE-IVD-CMYPVEYGKDS------------- egl-4_Cele ----MIRDAVQKNDFLKQLAKEQ-----IIE-LVN-CMYEMRARAGQ------------- C09G4.2_Cele ----TIGNALRLNSFLRNLDATQ-----IEK-ISS-AMYPVEVPAGA------------- PKG2_Spur ----VIRDAILLNDFTKNFDSSQ-----TRE-IVE-CMFPIDYKKGQ------------- PKG1_Spur ------------------------------------------------------------ AqueK021_Aque ----LIFRAITANDFLKNLEKVQ-----TTE-IVE-CMFPLDFKQDQ------------- PKG_Smoe ------------------------------------------------------------ PKG2_Hsap ---------YIIKQGEPG------------------NHIFVLAEGRLEVFQGEKLLSSIP PKG1_Hsap ---------CIIKEGDVG------------------SLVYVMEDGKVEVTKEGVKLCTMG for_Dmel EKGKGWKDFYVLSQ-DRHSSFYINRIGQNYDYDYPINFNIFSPDGRVEVSREGKYLSTLS CG4839_Dmel ---------LIIREHEEG------------------SEIYVSAEGQYDVIRGGQLVASFG Pkg21D_Dmel ---------FVIREGEVG------------------AHLYVSAAGEFAVMQQGKVLDKMG PKG2_Mmus ---------YVIKQGEPG------------------NHIFVLAEGRLEVFQGEKLLSSIP PKG1_Mmus ---------CIIKEGDVG------------------SLVYVMEDGKVEVTKEGVKLCTMG egl-4_Cele ---------WVIQEGEPG------------------DRLFVVAEGELQVSREGALLGKMR C09G4.2_Cele ---------IIIRQGDLG------------------SIMYVIQEGKVQVVKDNRFVRTME PKG2_Spur ---------IVINEGDSG------------------AHFYVGATGTLEVSQGDRVLATMG PKG1_Spur ------------------------------------------------------------ AqueK021_Aque ---------FICREGAVG------------------TELYVIAEGEVQVTKGGQVRTEMG PKG_Smoe ------------------------------------------------------------ PKG2_Hsap MWTTFGELAILYNCTRTASVKAITN-VKTWALDREVFQNIMRRTAQARDEQYRNFLRSVS PKG1_Hsap PGKVFGELAILYNCTRTATVKTLVN-VKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVP for_Dmel GAKVLGELAILYNCQRTATITAITE-CNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVP CG4839_Dmel PATVFGELAILYNAPRQASIEAATD-ARVWKIARETFRAIMQISGSREREENLQFLRSAP Pkg21D_Dmel AGKAFGELAILYNCTRTASIRVLSEAARVWVLDRRVFQQIMMCTGLQRIENSVNFLRSVP PKG2_Mmus MWTTFGELAILYNCTRTASVKAITN-VKTWALDREVFQNIMRRTAQARDEEYRNFLRSVS PKG1_Mmus PGKVFGELAILYNCTRTATVKTLVN-VKLWAIDRQCFQTIMMRTGLIKHTEYMEFLKSVP egl-4_Cele AGTVMGELAILYNCTRTASVQALTD-VQLWVLDRSVFQMITQRLGMERHSQLMNFLTKVS C09G4.2_Cele DGALFGELAILHHCERTATVRAIES-CHLWAIERNVFHAIMMESAREKTMSFKRHLKYSA PKG2_Spur PGKVFGELAILYNCTRTATITAVTD-AQVWAIDRKVFQLIMMKTGMQRHEEYFNFLKSVP PKG1_Spur ------------------------------------------------------------ AqueK021_Aque PGKLFGELAILYNCTRTATIKAKVD-TKVWALDRSCFQTIMMNHGIIRQSEYLSFLRSVP PKG_Smoe ------------------------------------------------------------ PKG2_Hsap LLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGH----D PKG1_Hsap TFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPS----E for_Dmel IFKDLAEDTLIKISDVLEETHYQRGDYIVRQGARGDTFFIISKGKVRVTIKQQDT----Q CG4839_Dmel FLQEFDQSLLLKVVDLLQRKFYETDSCIVREGELGNEFYIIRCGTVTIKKLDE-Q----Q Pkg21D_Dmel LLMNLSEELLAKIADVLELEFYAAGTYIIRQGTAGDSFFLISQGNVRVTQKLTPT---SP PKG2_Mmus LLKNLPEDKLTKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKVTQSTEGH----D PKG1_Mmus TFQSLPDEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGQVNVTREDSPS----E egl-4_Cele IFQNLSEDRISKMADVMDQDYYDGGHYIIRQGEKGDAFFVINSGQVKVTQQIEGE----T C09G4.2_Cele RFGGYPEEVLLRIAEFCTEMRYDAREELVVKP---QYVYLVCRGSVLCDDQGEVSKIVAG PKG2_Spur LLKDLSSDNLFKLANSLEVDFFHEGEYIIVEGSRGDTFYIISKGEVRITQSVQGQ----R PKG1_Spur ------------------------------------------------------------ AqueK021_Aque ELRMLNERDLMKLADVLQEDFYPQGEYIIRQRQTGETFFIISDGTVKITKQASPD----A PKG_Smoe ------------------------------------------------------------ PKG2_Hsap QPQLIKTLQKGEYFGEKALISDDVRSANIIAE-ENDVACLVIDRETFNQTVGTFEELQKY PKG1_Hsap DPVFLRTLGKGDWFGEKALQGEDVRTANVIAA-E-AVTCLVIDRDSFKHLIGGLDDVSNK for_Dmel EEKFIRMLGKGDFFGEKALQGDDLRTANIICESADGVSCLVIDRETFNQLISNLDEIKHR CG4839_Dmel QEQIVANRKRGDYFGEQALLNADVRQASVYAD-APGTEVLMLDREAFISYLGTIKQLREK Pkg21D_Dmel EETELRTLSRGDYFGEQALINEDKRTANIIAL-SPGVECLTLDRDSFKRLIGDLCELKEK PKG2_Mmus QPQLIKTLQKGEYFGEKALISDDVRSANIIAE-ENDVACLVIDRETFNQTVGTFDELQKY PKG1_Mmus DPVFLRTLGKGDWFGEKALQGEDVRTANVIAA-E-AVTCLVIDRDSFKHLIGGLDDVSNK egl-4_Cele EPREIRVLNQGDFFGERALLGEEVRTANIIAQ-APGVEVLTLDRESFGKLIGDLESLKK- C09G4.2_Cele QDFELRCGRKGRFERFFVLEG----PAHLIKM-HVEQLCKALD----------------- PKG2_Spur EPQEVRSLQKGDFFGEKALLGEDVRTANVLAS-KGGCECLAVDRQSFNELIGNMQALQDK PKG1_Spur ------------------------------------------------------------ AqueK021_Aque PEETIRELGRGDYFGEKALLGDKYRTASVIAT-S-NVCCLCVDRDHFTQLIGNLVERTYK PKG_Smoe ------------------------------------------------------------ PKG2_Hsap LEGYVANLNRDDEKRHAKRSMSNW------------------------------------ PKG1_Hsap A--------YEDAEAKA------------------------------------------- for_Dmel ---------YDDEGAME------------------------------------------- CG4839_Dmel PSS-----QRNDTSGRSST----------------------------------------- Pkg21D_Dmel D--------YGDESRKLAMKQA-------------------------------------- PKG2_Mmus LEGYVATLNRDDEKRHAKRSMSSW------------------------------------ PKG1_Mmus A--------YEDAEAKA------------------------------------------- egl-4_Cele D--------YGDKERLAQVVRE-------------------------------------- C09G4.2_Cele ------TTDLDDEI-RP------------------------------------------- PKG2_Spur N--------YGDKERGATRALRGVDSTDFDPIKGLVKWISKVTKRWYNLTINTLQEDDNK PKG1_Spur ------------------------------------------------------------ AqueK021_Aque D--------SEEKKLEG-V----------------------------------------- PKG_Smoe ------------------------------------------------------------ PKG2_Hsap -KLSKALSLE--MIQLKEKVARFSSSSPFQNLEIIATLGVGGFGRVELVKVKNE--NVAF PKG1_Hsap ---------------KYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSE-ESKTF for_Dmel ---------------RRKI-NEEFRDINLTDLRVIATLGVGGFGRVELVQTNGD-SSRSF CG4839_Dmel ---------------KSLEFDNEYSQVAISELKKIATLGCGAFGRVDLVAYN--Q--QAL Pkg21D_Dmel ----QES--C--RDEPKEQLQQEFPDLKLTDLEVVSTLGIGGFGRVELVKAHHQDRVDIF PKG2_Mmus -KLSKALSLE--MIQLKEKVARFSSTSPFQNLEIIATLGVGGFGRVELVKVKNE--NVAF PKG1_Mmus ---------------KYEAEAAFFANLKLSDFNIIDTLGVGGFGRVELVQLKSE-ESKTF egl-4_Cele ----PP---S--PVKIVDDFREEFAQVTLKNVKRLATLGVGGFGRVELVCVNGD-KAKTF C09G4.2_Cele ----------------RASSTIEEADVELEDLQRVSTLGMGGFGRVELVRSA---SSRTY PKG2_Spur FKKSSSSEMDNTEIARIKPIQDELAAIHLNDLDIIATLGVGGFGRVELVQLAGD--KRTF PKG1_Spur ----------------------------------------------NWVRLDG--SNQTY AqueK021_Aque --------------LIEDEDTKEYSMMTLDDLVRVETLGMGGFGRVELVQLKTD-STRTF PKG_Smoe ----------------------------------------GLFGKVKLVFCRRT--REYY . * PKG2_Hsap AMKCIRKKHIVDTKQQEHVYSEKRILEEL-CSPFIVKLYRTFKDNKYVYMLLEACLGGEL PKG1_Hsap AMKILKKRHIVDTRQQEHIRSEKQIMQGA-HSDFIVRLYRTFKDSKYLYMLMEACLGGEL for_Dmel ALKQMKKSQIVETRQQQHIMSEKEIMGEA-NCQFIVKLFKTFKDKKYLYMLMESCLGGEL CG4839_Dmel ALKIIKKIEVVKQDQIEHVYNEKNVMIKCRQSPFIVQLYRTYRNDKYVYFLMEACMGGDV Pkg21D_Dmel ALKCLKKRHIVDTKQEEHIFSERHIMLSS-RSPFICRLYRTFRDEKYVYMLLEACMGGEI PKG2_Mmus AMKCIRKKHIVDTKQQEHVYSEKRILEEL-CSPFIVKLYRTFKDNKYVYMLLEACLGGEL PKG1_Mmus AMKILKKRHIVDTRQQEHIRSEKQIMQGA-HSDFIVRLYRTFKDSKYLYMLMEACLGGEL egl-4_Cele ALKALKKKHIVDTRQQEHIFAERNIMMET-STDWIVKLYKTFRDQKFVYMLLEVCLGGEL C09G4.2_Cele ALKIMNKAHIVETKQESHVVSERRILMQC-DNDYIVRMYKTYRDSEKIYMLMEPCLGGEI PKG2_Spur ALKCLKKHHIVETRQQEHIFSEKKIMMES-SSPFIVKLFKTFRDQKYIYMLMEVCLGGEL PKG1_Spur ALKQLKKRHIVETRQQEHIMSEKNIMLEA-RCDFIVRLYCTFKDNKYLYMLLEACLGGEL AqueK021_Aque ALKCLRKKHIVDTRQQEHIFSEKSIMLSG-RSPFITRLYKTFRCPKYLYMLLEVCLGGEL PKG_Smoe ALKCVSKAKVIRLQEEEHLRNEKLFMTEM-DHPFITKLIRTYKDDKNIYLLQELTTGGEL *:* : * .:: : .*: *: .: :* :: *:: : :*:* * **:: PKG2_Hsap WSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDAEGYLKLVDFGFA PKG1_Hsap WTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFA for_Dmel WTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFA CG4839_Dmel WTVMSKRQYFDEKTAKFIAGCVVEAFDYLHSHHFIYRDLKPENLMLGTDGYCKLVDFGFA Pkg21D_Dmel WTMLRDRGSFEDNAAQFIIGCVLQAFEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFA PKG2_Mmus WSILRDRGSFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILDADGYLKLVDFGFA PKG1_Mmus WTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFA egl-4_Cele WTTLRDRGHFDDYTARFYVACVLEGLEYLHRKNIVYRDLKPENCLLANTGYLKLVDFGFA C09G4.2_Cele WTILRKKGRFDNDLTRFYCAGAMEALEYLHRKNIVYRDLKPENMLLDRNGWPKLVDFGFA PKG2_Spur WTILRDKGHFDDRTARFSTACVVEAFHYLHSRGIVYRDLKPENLLLDNKGYVKLVDFGFA PKG1_Spur -------GSFDDSTTRFYTACVTEALAYLHNKGIVYRDLKPENILLDNKGYGKLVDFGFA AqueK021_Aque WTILRDRGSFDDATTRFCTACVVEAFQYLHSREIVYRDLKPENLLLDNAGYVKLVDFGFA PKG_Smoe FFHMEKVGPLREAEASFYAGAVLLVLEYMHGKGIVYRDLKPENTLIGDNGYPKLIDMGFA : : : * . . : *:* ::******** :: *: *::*:*** PKG2_Hsap KKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFS-GVDQM- PKG1_Hsap KKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFS-GPDPM- for_Dmel KKLQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFT-GSDPM- CG4839_Dmel KFVRQNEKTNTFAGTPEYVAPEIILDRGHDRAVDYWALGILVYELLVGKTPFR-GVNQI- Pkg21D_Dmel KQIGTSSKTWTFCGTPEYVAPEIILNKGHDRAVDYWALGILIHELLNGTPPFS-APDPM- PKG2_Mmus KKIGSGQKTWTFCGTPEYVAPEVILNKGHDFSVDFWSLGILVYELLTGNPPFS-GIDQM- PKG1_Mmus KKIGFGKKTWTFCGTPEYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFS-GPDPM- egl-4_Cele KKLASGRKTWTFCGTPEYVSPEIILNKGHDQAADYWALGIYICELMLGRPPFQ-ASDPM- C09G4.2_Cele KKLKNGGRTWTFCGTAEYVAPEIVLNKGHDLSVDIWALGIFMCELLTGSPPFS-STDPM- PKG2_Spur KKIGFGRKTWTFCGTPEYVAPEIILNKGHDLSCDYWSLGILIFELLTGNPPFT-ANDPM- PKG1_Spur KRIGHGRKTWTFCGTPEYVAPEIILNRGHDLSADYWSLGILMFELLTGSPPFT-GSDPM- AqueK021_Aque KYIGPGRKTWTFCGTPEYVAPEIILNKGHDLSADYWSLGILMYELLTGSPPFS-GADPM- PKG_Smoe KRIY-NRRTYSMCGTPDYMAPEIIRRQGHGKAVDYWALGCLIFELITNTSAFNRGEDPPQ * : . :* ::.**.:*::**:: :**. : * *:** : **: . ..* . : PKG2_Hsap MTYNLILKGIEKMDFP-RKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLN-GF PKG1_Hsap KTYNIILRGIDMIEFP-KKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFE-GF for_Dmel RTYNIILKGIDAIEFP-RNITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFD-GF CG4839_Dmel KIYQQILSGIDVIHMP-SRIPKSAQHLVRHLCKQLPAERLGYQRKGIADIKRHSWFE-SL Pkg21D_Dmel QTYNLILKGIDMIAFP-KHISRWAVQLIKRLCRDVPSERLGYQTGGIQDIKKHKWFL-GF PKG2_Mmus MTYNLILKGIEKMDFP-RKITRRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWLN-GF PKG1_Mmus KTYNIILRGIDMIEFP-KKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFE-GF egl-4_Cele KTYTLILKGVDALEIPNRRIGKTATALVKKLCRDNPGERLGSGSGGVNDIRKHRWFM-GF C09G4.2_Cele VTYNAILKGLEKWAWP-RFVTKEAIDMMLSLCKYEPTERLGFG--DIGEIRHHIWFD-NF PKG2_Spur KTYNVILKGIDMVEFP-RKIPRSAGNLIKRLCRDNPGERIGYQKNGISDIKKHKWFQ-GF PKG1_Spur KTYNIILKGMDMIEFP-RKITRNAANMIKKLCKDNPTERLGYQKSGLKDIQKHKWFD-GF AqueK021_Aque RTYNIILKGIDVVDFP-KKITRSAQNLIKKLCRDNPAERLGYLRNGLNDIKGHRWFQ-GF PKG_Smoe LVFHRIIDG--RVKFP-PYVSSDCADIVRKLLDPNPETRLGCRKRGAADIKEHPFFAKSV : *: * * : :: * * *:* . :*: * :: .. PKG2_Hsap NWEGLKARSLPSPLQRELKGPIDHSYFDKYPPEKG-M-----------------PPDELS PKG1_Hsap NWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDNDEP-----------------PPDDNS for_Dmel YWWGLQNCTLEPPIKPAVKSVVDTTNFDDYPPDPEGP-----------------PPDDVT CG4839_Dmel DWQRLKLKQLPSPIKRPLKSWTDLQYFGPSGVENDYE-----------------PPEELS Pkg21D_Dmel DWDGLASQLLIPPFVRPIAHPTDVRYFDRFPCDLN-E-----------------PPDELS PKG2_Mmus NWEGLKARSLPSPLRRELSGPIDHSYFDKYPPEKG-V-----------------PPDEMS PKG1_Mmus NWEGLRKGTLTPPIIPSVASPTDTSNFDSFPEDSDEP-----------------PPDDNS egl-4_Cele DWEGLRSRTLKPPILPKVSNPADVTNFDNYPPDND-V-----------------PPDEFS C09G4.2_Cele DFVGFRAHRIRPPFIPSVANDIDTSNFDTFPAFDNFASGSDESGWDIDFFDNFASGSDES PKG2_Spur DWEGLRKQEIAAPLPPKVKGSSDCSNFDSYPKDVD-I-----------------PADETS PKG1_Spur NWEGLRKRSLTPPIVPTVRSNSDASNFDDYPPDHEAA-----------------PEDDTS AqueK021_Aque DWEGLKKRVVVPPIVPNVRGATDTSNFDHFPASQEDI-----------------PPDDLS PKG_Smoe NFQLLIRQKEEPPVSFTELM----------QVTLH-FPSAD----------------DS- : : .*. : PKG2_Hsap GWDKD--------------F PKG1_Hsap GWDID--------------F for_Dmel GWDKD--------------F CG4839_Dmel GWDKD--------------F Pkg21D_Dmel GWDAD--------------F PKG2_Mmus GWDKD--------------F PKG1_Mmus GWDID--------------F egl-4_Cele GWDEG--------------F C09G4.2_Cele GWDID--------------F PKG2_Spur GWDEH--------------F PKG1_Spur GWDKD--------------F AqueK021_Aque GWDKDFGEIQRTPAWCLRGY PKG_Smoe --SKT--------------R .