CLUSTAL W (1.83) multiple sequence alignment lok_Dmel MARDTQGTQGTQSQA-S------------------------------------NI-W--- CHK2_Mmus MKSHHQSHSSTSSKA-HDSASCSQSQGGFSQPQGTPSQLHELSQYQGSSSSSTGTVPSSS chk-2_Cele MVRGTKRRRSSAEKP-I-----------------------------------VVVPVTRD RAD53_Scer MENITQPTQQSTQAT-Q------------------------------------RFLIEKF DUN1_Scer MSLSTKREHSGDVTD-------------------------------------SSFKRQQR CHK2_Hsap MSRESDVEAQQSH----GSSACSQPHGSVTQSQGS------SSQSQGISSSSTSTMPNSS T08D2.7_Cele MVRETKRRRSSAEKP-I------------------------------------VVPVTRD FHAK1_Ddis MSQTNYIPSTPNK----------------------------------------STPPSEL FHAK2_Ddis MFKDIQTQNSYS-DELYSSQIY------------------------------STQQPQQP FHAK3_Ddis MDEATQRQDP-------------------------------------------------- FHAK4_Ddis MNSNKEETTADG-SV-------------------------------------STTEEQQQ FHAK5_Ddis MDELTQANTLA------------------------------------------------- Chk2_Spur MYESDMSTASAGGSA-S----------------------------------SSSIEPNST CC1G_09319_Ccin MDDEFNEPMHHEAYD-G------------------------------------EE-EQQT AqueK082_Aque ------------------------------------------------------------ AqueK083_Aque MDMSSCGPTLD------------------------------------------------- lok_Dmel ------------------------------------------------------------ CHK2_Mmus Q----------------------------------------------------------- chk-2_Cele DTMPVD------------------------------------------------------ RAD53_Scer SQEQIG------------------------------------------------------ DUN1_Scer SNKPSS------------------------------------------------------ CHK2_Hsap Q----------------------------------------------------------- T08D2.7_Cele DTMPVD------------------------------------------------------ FHAK1_Ddis SSTPID------------------------------------------------------ FHAK2_Ddis QQQPQQQQSTFSSQQSQSSSYDFIYSTPQIHSQNSQNSQFSQNPLYDDFIHSTQNSYSQR FHAK3_Ddis ----IE------------------------------------------------------ FHAK4_Ddis QQQPQQQEQINTTTA--------------------------------------------- FHAK5_Ddis ----I------------------------------------------------------- Chk2_Spur S----------------------------------------------------------- CC1G_09319_Ccin Q----------------------------------------------------------- AqueK082_Aque ------------------------------------------------------------ AqueK083_Aque ------------------------------------------------------------ lok_Dmel ------------------------------------------------------------ CHK2_Mmus ---------------------------SS-----------------HSSSGTLSSLETVS chk-2_Cele ------------------------------------------------------------ RAD53_Scer ------------------------------------------------------------ DUN1_Scer ------------------------------------------------------------ CHK2_Hsap ---------------------------SS-----------------HSSSGTLSSLETVS T08D2.7_Cele ------------------------------------------------------------ FHAK1_Ddis ------------------------------------------------------------ FHAK2_Ddis VSSQRSYSQKSSSSQISFSQIPSSQIQSSQIPSSQIHSSQIPSSQNQSSQKSQFSFSQIP FHAK3_Ddis ------------------------------------------------------------ FHAK4_Ddis -----------STTSN--GENTASD-NNN-----------------NSNNNNNNNTNNTN FHAK5_Ddis ------------------------------------------------------------ Chk2_Spur -----------------------SA-SAS-----------------LSSAGTLSSMETIP CC1G_09319_Ccin -----------------------------------------------------------S AqueK082_Aque ------------------------------------------------------------ AqueK083_Aque -------------------------------------------------------VSDLP lok_Dmel ------------------------------------------------------------ CHK2_Mmus TQELCSI----------------------------------------------------- chk-2_Cele ------------------------------------------------------------ RAD53_Scer ------------------------------------------------------------ DUN1_Scer ------------------------------------------------------------ CHK2_Hsap TQELYSI----------------------------------------------------- T08D2.7_Cele ------------------------------------------------------------ FHAK1_Ddis ------------------------------------------------------------ FHAK2_Ddis ---SSQIPSSQKRFFQSQNDDFVPSSQVTSLQDICLPQPIQQQQQQQQQQQQQQQQQQQQ FHAK3_Ddis ------------------------------------------------------------ FHAK4_Ddis TNNNCDI----------------------------------------------------- FHAK5_Ddis ------------------------------------------------------------ Chk2_Spur TQEVA------------------------------------------------------- CC1G_09319_Ccin TQEAS------------------------------------------------------- AqueK082_Aque ------------------------------------------------------------ AqueK083_Aque DTEVA------------------------------------------------------- lok_Dmel ------------------------------------------------------------ CHK2_Mmus ------------------------------------------------------------ chk-2_Cele ------------------------------------------------------------ RAD53_Scer ------------------------------------------------------------ DUN1_Scer ------------------------------------------------------------ CHK2_Hsap ------------------------------------------------------------ T08D2.7_Cele ------------------------------------------------------------ FHAK1_Ddis ------------------------------------------------------------ FHAK2_Ddis QQQQQQQQQQQQCQPQQQQTQQQQQQQQQQQQQQQQQQQQQQQQQQTQQQQQQPQEDDDD FHAK3_Ddis ------------------------------------------------------------ FHAK4_Ddis ------------------------------------------------------------ FHAK5_Ddis ------------------------------------------------------------ Chk2_Spur ------------------------------------------------------------ CC1G_09319_Ccin ------------------------------------------------------------ AqueK082_Aque ------------------------------------------------------------ AqueK083_Aque ------------------------------------------------------------ lok_Dmel ----------------------------------------------------TQVESQP- CHK2_Mmus ----------------------------------------------P-----EDQEPEE- chk-2_Cele ----------------------------------------------------EDLVVGES RAD53_Scer ----------------------------------------------------ENIVCRVI DUN1_Scer ------------------------------------------------------------ CHK2_Hsap ----------------------------------------------PEDQEPEDQEPEE- T08D2.7_Cele ----------------------------------------------------EDLVVEES FHAK1_Ddis ------------------------------------------------------------ FHAK2_Ddis YDDYDGYDNYEDFVYNEGEEGEEDYEDYEQENDDDDDEDEDDDDDDDD--DDDDEEEEE- FHAK3_Ddis ---------------------------------------------------ETDAEKKV- FHAK4_Ddis ----------------------------------------------SM---TEDNSKEE- FHAK5_Ddis ---------------------------------------------------DEDLVDSV- Chk2_Spur ---------------------------------------------------EGDFDFAE- CC1G_09319_Ccin -----------------------------------------------QS--QSQSPGQA- AqueK082_Aque --------------------------------------------------------AEE- AqueK083_Aque -----------------------------------------------VD--ETDGAAEE- lok_Dmel ------------------------------------------------------------ CHK2_Mmus ------------------------------------------------------------ chk-2_Cele Q----------------------------------------------------------- RAD53_Scer C----------------------------------------------------------- DUN1_Scer ------------------------------------------------------------ CHK2_Hsap ------------------------------------------------------------ T08D2.7_Cele Q----------------------------------------------------------- FHAK1_Ddis ------------------------------------------------------------ FHAK2_Ddis ESQQQHIRSRALQSRSSQSRPLLRSGFKSPISRLSQTKTSPEYIYISSQSNTHTNQLGQS FHAK3_Ddis ------------------------------------------------------------ FHAK4_Ddis DTGI-------------------------------------------------------- FHAK5_Ddis ------------------------------------------------------------ Chk2_Spur ------------------------------------------------------------ CC1G_09319_Ccin ------------------------------------------------------------ AqueK082_Aque ------------------------------------------------------------ AqueK083_Aque ------------------------------------------------------------ lok_Dmel ------------------------------------------------------------ CHK2_Mmus ------------------------------------------------------------ chk-2_Cele ------------------------------------------------------------ RAD53_Scer ------------------------------------------------------------ DUN1_Scer ------------------------------------------------------------ CHK2_Hsap ------------------------------------------------------------ T08D2.7_Cele ------------------------------------------------------------ FHAK1_Ddis ------------------------------------------------------------ FHAK2_Ddis SQQTNSPNVHFNSLQQKKKQQQQQQQQQQQQQQQQQQQQQQQQQQQSQQIIGSQSSQSSQ FHAK3_Ddis ------------------------------------------------------------ FHAK4_Ddis ------------------------------------------------KV---------- FHAK5_Ddis ------------------------------------------------------------ Chk2_Spur ------------------------------------------------------------ CC1G_09319_Ccin ------------------------------------------------------------ AqueK082_Aque ------------------------------------------------------------ AqueK083_Aque ------------------------------------------------------------ lok_Dmel --------MEKIVWGRLYGKN-IKI-K--------------------------------- CHK2_Mmus --------PGPAPWARLWALQ-DGF-S--------------------------------- chk-2_Cele -------CAASKPFAKLVGVR-RGI-S--------------------------------- RAD53_Scer -------TTGQIPI---RDLS-ADI-SQVLK----------------------------- DUN1_Scer ---------EYTCLGHLVNLI-PGKEQ--------------------------------- CHK2_Hsap --------PTPAPWARLWALQ-DGF-A---NLETESGHVTQSDLELLLSSDPPASASQSA T08D2.7_Cele -------CAALKPFAKLVGVR-RGI-S--------------------------------- FHAK1_Ddis ---------E-NDIGLLVSLN-QEISS--------------------------------- FHAK2_Ddis LPPTQPPVEVPVNLGRLIPIN-ASH-I--------------------------------- FHAK3_Ddis -------QVVPSLWGRLVSNH-PES-R--------------------------------- FHAK4_Ddis -------IGEGELWGKLISLN-PTY-P--------------------------------- FHAK5_Ddis --------NSVKGWGILKSLN-PSY-P--------------------------------- Chk2_Spur --------ERVVVWGRLYPVG-KCF-S--------------------------------- CC1G_09319_Ccin --------VDAHLWGYLQPVN-DKL-I--------------------------------- AqueK082_Aque --------QSLEIWGRFFPLPRAGL-T--------------------------------- AqueK083_Aque --------QSLEIWGRFFPLPRAGL-T--------------------------------- lok_Dmel -------------SLDLN---NDEFTAGRGEA-NDLI-L--TLNDLP-E-KILTRISKVH CHK2_Mmus -------------NLDCV---NDNYWFGRDKS-CEYC-F--DGPLLR-RTDKYRTYSKKH chk-2_Cele -------------SIDL---ADDHFVCGRGSDDAPTN-F--NFSQVAKDVGLYRFISKIQ RAD53_Scer -------------EKRS---IKKVWTFGRNPA-CDYH-L--GN---------ISRLSNKH DUN1_Scer -------------K--VEITNRNVTTIGRSRS-CDVI-L--SEP----------DISTFH CHK2_Hsap GIRGVRHHPRPVCSLKCV---NDNYWFGRDKS-CEYC-F--DEPLLK-RTDKYRTYSKKH T08D2.7_Cele -------------SIDL---ADDHFVCGRGSHDAPTN-F--NFSTVAEDVGLYKFISKIQ FHAK1_Ddis -------------NIHVKIKIEENITIGRSKT-CNIV-V--PEL----------IVSGKH FHAK2_Ddis -------------PINLNLKREDRIVVGRSSS-CDAR-LIDNYL----------TISGKH FHAK3_Ddis -------------HIDL---IEHSIFFGRNPKRCQVV-L--HDP----------TVSGIH FHAK4_Ddis -------------TIEI---RQDSIILGRSKGVCNYT-F--TSP----------TVSGKH FHAK5_Ddis -------------DISL---VENVITFGRLKD-STVH-Y--NDK----------SISGSH Chk2_Spur -------------SIDFL-DTKDEYIFGRDPS-CDVC-Y--NGPEIS-KNPCYQTLSKTH CC1G_09319_Ccin -------------RIDFW-RAEPSYTIGRNTT-CNRIIF--PGF----------KVSNKH AqueK082_Aque -------------GIDFL---DDEYIFGRSED-CDYC-F--ERRGGT-SNQHYPTYSSTH AqueK083_Aque -------------GIDFS---DDEYIFGRSED-CDYC-F--ERRGGT-SNQHYPTYSSTH ** * : lok_Dmel FIIKRANC--------------------------------------------------EL CHK2_Mmus FRIFREMG-------------------------------------------------PKN chk-2_Cele FSIDRD----------------------------------------------------TE RAD53_Scer FQILLG-----------------------------------------------------E DUN1_Scer AEFHLLQM----------------------------------------------DVDNFQ CHK2_Hsap FRIFREVG-------------------------------------------------PKN T08D2.7_Cele FSIDRD----------------------------------------------------TE FHAK1_Ddis CIITRADAI---------------------------------------------ENGNTN FHAK2_Ddis CEIYRADNLTCLK--HIPLC-------------------------------KDKTDCHKN FHAK3_Ddis CRIFREEIPCQKYNNNNNNDGDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTTK FHAK4_Ddis CKIYRDP------------------------------------------------TVKS- FHAK5_Ddis CKITRES------------------------------------------------NDDDG Chk2_Spur FRIFKESN--------------------------------------------------DN CC1G_09319_Ccin CTITWNGS-------------------------------------------------DSN AqueK082_Aque FRIYRERS-----------------------------------------------KTDSN AqueK083_Aque FRIYRERS-----------------------------------------------KTDSN : lok_Dmel TNPVYIQDLSRNGTFVNNEKIGTNRMRILKNDDVISLSHPTY--------K----AFVFK CHK2_Mmus CYIVYIEDHSGNGTFVNTELIGKGKRCPLSNNSEIALSLCRN--------K----VFVFF chk-2_Cele TRRIYLHDHSRNGTLVNQEMIGKGLSRELMNGDLISIGIPAL--------I----IFVYE RAD53_Scer DGNLLLNDISTNGTWLNGQKVEKNSNQLLSQGDEITVGVGVESD------ILSLVIFIND DUN1_Scer RNLINVIDKSRNGTFINGNRLVK-KDYILKNGDRIVFGKSCSF------------LFKYA CHK2_Hsap SYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSLSRN--------K----VFVFF T08D2.7_Cele TRRIYLHDHSRNGTLVNHEMIGKGLSRELMNGDLISIAIPAL--------I----IFVYE FHAK1_Ddis YGLLMIQDQSTNGTFINGKLIGKGKSRLLKNGDKLCLGKSTKEI-----DI----SFLYK FHAK2_Ddis FGMLIVHDISSNGSYINGELIGNGKTRILRSDDILSLGHPSG-------DL----KFIFE FHAK3_Ddis NYITKITDTSSNGTFVKGCILGKDKTTIIQNGDMVSFTSAKLIS-----SL----SFTFL FHAK4_Ddis RNVAFVDDTSTNGTFINNEVIGKGSKILIENGCEISVIPKKGSE-----KI----SFIYQ FHAK5_Ddis VVIAFIYDNSTNGTFIDNIKVGKGSRCLLASGQEISLTPQKQLE-----KI----AYIFQ Chk2_Spur CNFYFIEDKSSNGTFVNGEKIGKGKKQVLNNNDEIALSLSKN--------K----AYVFM CC1G_09319_Ccin -GSVVVLDLSSNGTFINGSKIGKNNSRILRDGNEIAFGTPSPQPNNPHEDY----RFIYR AqueK082_Aque QFVVFLQDKSSNGTFINGDKIGKNKTHILNNDDEISLSVKNN--------K----VFVFN AqueK083_Aque QFVVFLQDKSSNGTFINGDKIGKNKTHILNNDDEISLSVKNN--------K----VFVFN : * * **: :. : . : .. : . : lok_Dmel DLS--------PN----------------------------------------------- CHK2_Mmus DLT--------VD----------------------------------------------- chk-2_Cele SAD--------------------------------------------------------- RAD53_Scer KFK--------QCLEQNKVDRI---------------------RSNLKNTSKIASPGLTS DUN1_Scer SSS--------STDIENDDEKVSSESRSYKNDDEVFKKPQISATSSQN-ATTSAAIR--- CHK2_Hsap DLT--------VD----------------------------------------------- T08D2.7_Cele RAD--------------------------------------------------------- FHAK1_Ddis SNY--------SNQLLLSS-----------------------STNNLNNSGTAQYI---- FHAK2_Ddis SEFQFNFILDIKDNVNNLNENLDYK--------K------L----------RTAYDN--- FHAK3_Ddis DLT--------NP----------------------------------------------- FHAK4_Ddis DCF--------EE----------------------------------------------- FHAK5_Ddis TVE--------------------------------------------------------- Chk2_Spur DTK--------DS----------------------------------------------- CC1G_09319_Ccin HA---------------------------------------------------------- AqueK082_Aque DRS--------VS----------------------------------------------- AqueK083_Aque DRS--------VS----------------------------------------------- lok_Dmel ---ESI-GLPEEINKTYY-VNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPS CHK2_Mmus ---DQS-VYPKELRDEYI-MSKTLGSGACGEVKMAFERKTCQKVAIKIISKRRFALG-SS chk-2_Cele ----A-DHHPEELTKKYHVTSHSLGKGGFGKVLLGYKKSDRSVVAIKQLNTQFS-TRCS- RAD53_Scer STASSMVANKTGIFKDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKV-IGN-- DUN1_Scer ---KLNKTRPVSFFDKYL-LGKELGAGHYALVKEAKNKKTGQQVAVKIFHAQQN-DDQ-K CHK2_Hsap ---DQS-VYPKALRDEYI-MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIG-SA T08D2.7_Cele ----D-NHHPEELTNKYHVTSHLLGKGGFGKVLLGYKKSDRSVVAIKQLNTQFS-TRCS- FHAK1_Ddis ---WERKDIKDDILKDYD-FIKELGSGNFSVVYEGVNKNTGKRVAIKHLNLSKINTHTPK FHAK2_Ddis ---ARIENKNCALRD-YY-FVKEIGSGGYGIVYEGLYKLNGKRVAIKHIDLLKNGST-SK FHAK3_Ddis ---YIDEPFEEEMNKKYS-IQGILGTGNFSVVKRCIRRDTGEVFAVKIIDKKKFWSQ-TK FHAK4_Ddis ---Q-KEMEQGGPQQKYD-LREVLGTGNFASVRLGVEKETGNKYAIKIIDKKKMSMT-SK FHAK5_Ddis -----KEIEDGGPSNKYF-IGEMLGQGNFATVKLAVERTTGVKYAVKIVDKKKYFMNSSA Chk2_Spur ---DQS-NLPEALREKFI-MSKVLGRGACGQVKLAFEKGTCRKVAVKIIEKKTFSIG-GT CC1G_09319_Ccin ----ANGPPTTGLYAYYD-VSTELGKGSFATVMKAVNRKTGVWYAVKMIKDKRAAHA-GD AqueK082_Aque ---EQNNN-LPEFKDKYT-MSKQIGKGACGIVKLAFHRETCKGYAIKIISKKMFSVG-PH AqueK083_Aque ---EQNNNLPEEFKDKYT-MSKQIGKGACGIVKLAFHRETCKGYAVKIISKKMFSVG-PH : :* * . * *:* . lok_Dmel TNFSDPDRVLNEAKIMKNLSHPCVVRMHDIVDK-----PDSVYMVLEFMRGGDLLNRIIS CHK2_Mmus READTAPSVETEIEILKKLNHPCIIKIKDVFDA-----E-DYYIVLELMEGGELFDRVVG chk-2_Cele RAIAKTRDIRNEVEVMKKLSHPNIVAIYDWITV-----AKYSYMVIEYVGGGEFFSKVVD RAD53_Scer -----MDGVTRELEVLQKLNHPRIVRLKGFYED-----TESYYMVMEFVSGGDLMDFVAA DUN1_Scer ----KNKQFREETNILMRVQHPNIVNLLDSFVEPISKSQIQKYLVLEKIDDGELFERIVR CHK2_Hsap READPALNVETEIEILKKLNHPCIIKIKNFFDA-----E-DYYIVLELMEGGELFDKVVG T08D2.7_Cele RAIAKTRDIQNEVEVMKKLSHPNIVAIYDCITV-----AKYSYMVIEYVGGGEFFSKLVD FHAK1_Ddis ----FKSQLNREIEILKFINHENVVEIYDIFYT----KDQQLFFILELANGGELYNKIGF FHAK2_Ddis ----SMELVSKEYNALKNIKHRNVIEFFDIVFS-----STDCFFIVELATN-DL-SNLLR FHAK3_Ddis ----TRRQMESEVEILQKIKHPNIISIIDIVQS-----DRYFYIVLELATGGELFEKIKQ FHAK4_Ddis ----RKDSLMDEVNVLTKVKHQNIISIKEVFET-----QKNLYLVLELVTGGELFDKIVS FHAK5_Ddis ----RKDSLMDEVNILRGLSHPNIIQIIEVFEN-----EKVLSLILELVECGELLNDIVS Chk2_Spur MVRNMEKTVMEEVRILKRLHHPCIIGIEDVCDT-----PEVLYIVLELVESGELFDRVVS CC1G_09319_Ccin I---RNSAIAREISIMEKLKHRNICELKEVFME---EGSSDINLVLELVEGGDLLEYILN AqueK082_Aque ----LGRAAMEEVKIIKALQHPCIIRVEDLYES-----TDSLYIVLELVEGGELFDRVIL AqueK083_Aque ----LGRAAMEEVKIIKALQHPCIIRVEDLYES-----TDSLYIVLELVEGGELFDRVIL * : : * : . :::* :: . : lok_Dmel N----KLLSEDISKLYFYQMCHAVKYLHDRGITHRDLKPDNVLLETN------------- CHK2_Mmus N----KRLKEATCKLYFYQMLVAVQYLHENGIIHRDLKPENVLLSSQ------------- chk-2_Cele SKYNRMGLGESLGKYFAFQLIDAILYLHSVGICHRDIKPENILCSDK------------- RAD53_Scer HG----AVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQ-------------- DUN1_Scer K----TCLRQDESKALFKQLLTGLKYLHEQNIIHRDIKPENILLNITRRENPSQVQLGPW CHK2_Hsap N----KRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQ------------- T08D2.7_Cele SKYNQMGLGESLGKYFAFQLIDAVLYLHSVGICHRDIKPENILCSNK------------- FHAK1_Ddis NE---PLLNENQSKFIFKQILNAVSYLHSKGIAHRDLKPENILFDSYG------------ FHAK2_Ddis K----RCVDEDDIKRICKQLLLGFNYLHNLGIVHRDLKPENILYNEF------------- FHAK3_Ddis K----GRFSEPEAKDTFKQILEAVSYLHDLNISHRDLKPENILISAVS------------ FHAK4_Ddis E----RKFQEDTCRYILKQLCDSVRYLHSNGIAHRDLKPENILLAT-------------- FHAK5_Ddis N----LFYTEDKAKTLFRQIVDGVLYLHNKGIAHRDLKPENILLKHKN------------ Chk2_Spur L----GKFDEATAKFYFYQMITACKYLHDNGITHRDLKPENLLLMSD------------- CC1G_09319_Ccin R----GGLSEVDAKHITHQICSALSYIHQQGIAHRDLKPENVLLTKS------------- AqueK082_Aque N----GKFNDKVGKLLFYQMVVAVKYLHDKGITHRDLKPENILLSST------------- AqueK083_Aque N----GKFNDKVGKLLFYQMVVAVKYLHDKGITHRDLKPENILLSST------------- : : *: . *:*. .* ***:**:*:* lok_Dmel ---DEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITG---------------- CHK2_Mmus ---EEDCLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLVSN---------------- chk-2_Cele ---AERCILKLTDFGMAKN--SVNRMKTRCGTPSYNAPEIVANEG--------------- RAD53_Scer ---DDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSV--SP-------- DUN1_Scer DEDEIDIQVKIADFGLAKFTGEMQFTNTLCGTPSYVAPEVLTK----------------- CHK2_Hsap ---EEDCLIKITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSV---------------- T08D2.7_Cele ---AERCILKLTDFGMAKN--SVNRMKTHCGTPSYCAPEIVANQG--------------- FHAK1_Ddis ---DDYLKIKITDFGLARFIHEGELAKTLCGSPLYVAPEVILSLHHKNKYGTNSSSSSQS FHAK2_Ddis ---KQGFSIKITDFGLSSFVEESQYLQTFCGTPLFFAPEVIANNF--------------- FHAK3_Ddis --HGKSSVIKVTDFGLAKIIGEKEMATTLCGTPLYVAPEIIRNCLHGD--G--------- FHAK4_Ddis ---PNSFLLKISDFGLSRAMDEGTYMKTMCGTPQYVAPEILTKG---------------- FHAK5_Ddis --FNQNDAIKLTDFGLSRTVSDGSFMKTMCGTPQYLAPEILTSSG--------------- Chk2_Spur ---DKETILKVTDFGLSKFVGEQSLMKTLCGTPTYLAPEILTSM---------------- CC1G_09319_Ccin ----NPPVVKVADFGLAKIVDSLTMLRTMCGTPSYLAPEVVKQV---------------- AqueK082_Aque ---DEETLIKVTDFGLSKFVGEQSLMKTLCGTPSYLAPEVLWSA---------------- AqueK083_Aque ---DEETLIKVTDFGLSKFVGEQSLMKTLCGTPSYLAPEVIKSA---------------- :*::*** : . * **: : ***:: lok_Dmel -----GREAYTKKVDIWSLGVVLFTCLSGTLPFSDEY----GT-PAAQQIKKGRFAYGHP CHK2_Mmus -----GTAGYSRAVDCWSLGVILFICLSGYPPFSEHK----TQVSLKDQITSGKYNFIPE chk-2_Cele -------VEYTPKVDIWSLGCVLFITFSGYPPFSEEY----TDMTMDEQVLTGRLIFH-A RAD53_Scer -DEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGST----Q-DQLYKQIGRGSYHEGPL DUN1_Scer -------KGYTSKVDLWSAGVILYVCLCGFPPFSDQL----GPPSLKEQILQAKYAFYSP CHK2_Hsap -----GTAGYNRAVDCWSLGVILFICLSGYPPFSEHR----TQVSLKDQITSGKYNFIPE T08D2.7_Cele -------VEYTPKVDIWSLGCVLFITFSGYPPFSEEY----TDLKMDEQVLTGRLFFH-E FHAK1_Ddis PTKDINSVGYGKSCDAWSLGAILYIVLCGTPPFDDDDDEEMSTPQLFEKIVSGNYRVEKL FHAK2_Ddis -----FSNGYGKSCDLWSIGVTLYLSLCKYKPFIVDC----R--DLYHSFINGNLGFTSK FHAK3_Ddis --GAQVNTGYGKEVDVWSLGCILYILLSGRPPFDFDH----TNNFNLKLINQGLYNFSLP FHAK4_Ddis -----EREGYGKSVDLWSIGVITYILLCGFPPFGDPQ-----TKDFFEKIKNGGFSFPSP FHAK5_Ddis -----GHNGYGLEVDCWSMGAILYIMLCGYPPFDDSR-----EVSIFEQIRNAKFEFDPE Chk2_Spur -----GMGGYTKAVDCWSIGVILYICLAGYPPFSDEI----KAMNLDEQIKRGYYSFPTK CC1G_09319_Ccin -----NQEGYDNLVDSWSVGVIVFSMLTNASPFIEDE----TQRDIRTRIAERRIDWSVL AqueK082_Aque -----GLGGYSKAVDCWSLGVILYIMLGGYPPFSDEI----REHSLHDQICQGIYSFPPA AqueK083_Aque -----GLGGYSKAVDCWSLGVILYIMLGGYPPFSDEI----REHSLHDQICQGIYSFPPA * * ** * : : ** . lok_Dmel SWKSVSQRA--KLLINQMLIVDPERRPSIDDVLQSSWLRDAPMLQKAKRLMKLDGME--- CHK2_Mmus VWTDVSEEA--LDLVKKLLVVDPKARLTTEEALNHPWLQDEYMKKKFQDLLVQEKNS--- chk-2_Cele QWRRITVET--QNMIKWMLTVEPSNRPSAVELMSTQWMKCADCRTAKQ------------ RAD53_Scer KDFRISEEA--RDFIDSLLQVDPNNRSTAAKALNHPWIKMSPLGSQSYGDFSQISLSQSL DUN1_Scer YWDKIDDSV--LHLISNLLVLNPDERYNIDEALNHPWFNDIQQQSSVS--LELQR----- CHK2_Hsap VWAEVSEKA--LDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENES--- T08D2.7_Cele QWHRITDET--QNMIQWMLTVEPLIRPSAVELMSTQWMKCADCLSAKQ------------ FHAK1_Ddis EKSLISSSA--ADLVKGLLTVDPDKRLTVEQALNHPWITEINNNSNNNN-NNINN----- FHAK2_Ddis KWAKISNYA--KDLVRRLLVIDPEHRITIKEALNHPWFTQDRRFFKK--YPKHYKSRAQP FHAK3_Ddis VWDVVTENA--KDLIKKLLNVDPTKRISTKGALSHDWFNDDDLLRCSTVIANQSPISKSP FHAK4_Ddis YWDEISDEA--KSLIKNLIKVDVEKRFTIDQALNHPWFTNHEEKTKE--FYEKDK----- FHAK5_Ddis DWSSVSEEA--KDLIKRLLCVDPHKRYTCNNIIQHPWFNPNVKLSTL--LEEDERLRKKA Chk2_Spur YWGSVSAPDVFIRMVRWISIL------------------------------KCPNDA--- CC1G_09319_Ccin EAQNPSAEC--IHFIRSLLQEDPSVRMSLTQALDHPWLQSYIPVHQSQDQYLLAGVS--- AqueK082_Aque YWNGVSKD------------VDSSKRWTTAQALEHTWLKDEDMRRKAHQMMVETADK--- AqueK083_Aque YWNGVSKDG--IDLIEKLLTVDSSKRWTSAQALEHTWLKDEDMRKKAHQMMMETADK--- lok_Dmel -----------------------IE---------------------E------------- CHK2_Mmus -----------------------VT---------------------LPV---------AP chk-2_Cele ------------------------------------------------------------ RAD53_Scer SQQ-KLLENMDDAQYEFVKAQRKLQMEQQLQEQDQEDQDGKIQGFKIPAHAPIRYT--QP DUN1_Scer ------------------------------------------------------------ CHK2_Hsap -----------------------TA---------------------LPQ---------VL T08D2.7_Cele ------------------------------------------------------------ FHAK1_Ddis ------------------------------------------------------------ FHAK2_Ddis -KTQFF-----------------VE---------------------CFN----------- FHAK3_Ddis QRSHGV-----------------VQ---------------------LPVVDVKSKN--IP FHAK4_Ddis -----------------------LE---------------------FPPPSTNDDHQPTP FHAK5_Ddis E---AE-----------------VE---------------------ANNNNTNK--SNSP Chk2_Spur -----------------------KL---------------------I-----------G- CC1G_09319_Ccin ------------------------S---------------------SPD-------VTSP AqueK082_Aque -----------------------HQ---------------------MPP----------P AqueK083_Aque -----------------------HQ---------------------MPP----------P lok_Dmel ------------------------------------------------------------ CHK2_Mmus A----------------------------------------------------------- chk-2_Cele ------------------------------------------------------------ RAD53_Scer KSIEA------------------------------------------------------- DUN1_Scer ------------------------------------------------------------ CHK2_Hsap A----------------------------------------------------------- T08D2.7_Cele ------------------------------------------------------------ FHAK1_Ddis ------------------------------------------------------------ FHAK2_Ddis ------------------VYYDLKSETGFICF------------------------REHF FHAK3_Ddis MTLNS------------------------------------------------------- FHAK4_Ddis NTTSSNS----------------------------------------------------- FHAK5_Ddis KMLGKRKSEDGNCSDSNNNNNSGSKSLSS------------------------------- Chk2_Spur ------------------------------------------------------------ CC1G_09319_Ccin S--------------------------AGVSHDFIGLQIQPSAPRREGSRGAPLQRRSH- AqueK082_Aque S----------------------------------------------------------- AqueK083_Aque S----------------------------------------------------------- lok_Dmel --------------------------------E--------------------------- CHK2_Mmus ------------------------------QT-S-------------------------- chk-2_Cele ------------------------------------------------------------ RAD53_Scer -------------------------------ETRE-Q-----KLLHSNNTENVKSSKKKG DUN1_Scer ------------------------------------------------------------ CHK2_Hsap ------------------------------QPST-------------------------- T08D2.7_Cele ------------------------------------------------------------ FHAK1_Ddis ---------------------------------------------------------NSS FHAK2_Ddis DNLETNYALFK-----------------QNFDNNNNNNNNNNNNNNNNNNNNNNNNNINN FHAK3_Ddis -------------------------------TTT-NT-----TSPNNNNNNNNNNNNKNN FHAK4_Ddis ----------------------------QLVPESKCDQIQD-----NTT----------- FHAK5_Ddis --IKSNTTMLD-CDEKSNNNNNNGHKKSKSDPTSNNSLFNNDNNNNNNNNNNNNNNNNNN Chk2_Spur -------------------------------PD--------------------------- CC1G_09319_Ccin --------VLSQAAEEGR-----PVPEP--SPEM----IA-------------------- AqueK082_Aque ------------------------------LP---------------------------- AqueK083_Aque ------------------------------LP---------------------------- lok_Dmel ------------------------------------------------------------ CHK2_Mmus ------------------------------------------------------------ chk-2_Cele ------------------------------------------------------------ RAD53_Scer NGRFLTLKPLPDSIIQESLEIQQGVNPFFIGRSEDCNCKIEDN--RLSRVHCFIFKKRHA DUN1_Scer ------------------------------------------------------------ CHK2_Hsap ------------------------------------------------------------ T08D2.7_Cele ------------------------------------------------------------ FHAK1_Ddis NINI---------IKKS---------------------PLKTV--NT------------- FHAK2_Ddis NNNN---------INNN---------------------NINNN--N-------------- FHAK3_Ddis NKNI---------IKSL---------------------NSNSN--N-------------- FHAK4_Ddis ------------------------------------------------------------ FHAK5_Ddis NN--------------------------------------N-NNNNN------------- Chk2_Spur ------------------------------------------------------------ CC1G_09319_Ccin ------------------------------------------------------------ AqueK082_Aque ------------------------------------------------------------ AqueK083_Aque ------------------------------------------------------------ lok_Dmel ------------------------------------------------------------ CHK2_Mmus ------------------------------------------------------------ chk-2_Cele ------------------------------------------------------------ RAD53_Scer VGKSMYESPAQGLDDIWYCHTGTNVSYLNNNRMIQGTKFLLQDGDEIKIIWDKNNKFVIG DUN1_Scer ------------------------------------------------------------ CHK2_Hsap ------------------------------------------------------------ T08D2.7_Cele ------------------------------------------------------------ FHAK1_Ddis -------------------------NNN-NNN---------------------------- FHAK2_Ddis -------------------------NNN-NNNN--------------------------- FHAK3_Ddis -------------------------YNN-NSVL--------------------------- FHAK4_Ddis ------------------------------------------------------------ FHAK5_Ddis -------------------------NN--------------------------------- Chk2_Spur ------------------------------------------------------------ CC1G_09319_Ccin ------------------------------------------------------------ AqueK082_Aque ------------------------------------------------------------ AqueK083_Aque ------------------------------------------------------------ lok_Dmel ------------------------------------------------------------ CHK2_Mmus ------------------------------------------------------------ chk-2_Cele ------------------------------------------DIL--------------- RAD53_Scer FKVEINDTTGLFNEGLGMLQEQRV--VLKQTAEEKDLVKKLTQMMAAQRANQPSASSSSM DUN1_Scer ------------------------------------------------------------ CHK2_Hsap ------------------------------------------------------------ T08D2.7_Cele ------------------------------------------DIL--------------- FHAK1_Ddis -------------------CK--LSSPIKNSS---------------------------- FHAK2_Ddis -------------------NNT-NTNNINNN----------------------------- FHAK3_Ddis -------------------KKT-SQSPKTKSN---------------------------- FHAK4_Ddis ------------------------------------------------------------ FHAK5_Ddis ------------------------------------------------------------ Chk2_Spur ------------------------------------------------------------ CC1G_09319_Ccin ------------------------------------------------------------ AqueK082_Aque ------------------------------------------------------------ AqueK083_Aque ------------------------------------------------------------ lok_Dmel ------------------------------------------------------------ CHK2_Mmus -SQK-------------------------------------------------------- chk-2_Cele ------------------------------------------------------------ RAD53_Scer SAKK-------------------------------------------------------- DUN1_Scer ------------------------------------------------------------ CHK2_Hsap -SRK-------------------------------------------------------- T08D2.7_Cele ------------------------------------------------------------ FHAK1_Ddis -KLK-------------------------------------------------------- FHAK2_Ddis -----------NNNYNNSHNHNNNNHNHNHNLNNHNHNNNHHHNHNHNHNHNHNHNHNHN FHAK3_Ddis -RPKLQFEQPSP------------------------------------------------ FHAK4_Ddis ------------------------------------------------------------ FHAK5_Ddis ------------------------------------------------------------ Chk2_Spur ------------------------------------------------------------ CC1G_09319_Ccin -QAT-------------------------------------------------------- AqueK082_Aque -GSK-------------------------------------------------------- AqueK083_Aque -GSK-------------------------------------------------------- lok_Dmel ------------------------------------------------------------ CHK2_Mmus --------------RPL-ELE--VEGMPSTK----------------------------- chk-2_Cele --------------------------------------------------KSIKPISAA- RAD53_Scer --------------PPV-SDT--NNNGNNSVLNDLVESPI--NANTGNILKRIHSVSLSQ DUN1_Scer ------------------------------------------------------------ CHK2_Hsap --------------RPR-EGE--AEGAETTK----------------------------- T08D2.7_Cele --------------------------------------------------KSIQPISA-- FHAK1_Ddis --------------RNL-SNEPLNNNISNNNNTQTSFTG---SLL--------------N FHAK2_Ddis HNHNHNHNHNNHNNNNN-NNNNNNNNNNNNNNNNNNNNNNN-NN---------------- FHAK3_Ddis ---------NQHNNNNN-NNNNNNNNNNNNNNNNNSSGGKP-AII--------------N FHAK4_Ddis ------------D-NNN-NNNNNNNNNNNNNNNNTTNNSN--NID--------------N FHAK5_Ddis ------------NNNNNNNNNNNNNNNNNNNNNNNSNDTTDSDTD--------------D Chk2_Spur ----------------------------N------------------------------- CC1G_09319_Ccin --------------RSP-RDQ--TKRNKRV-RGNLTPLQE--ESD--------------A AqueK082_Aque --------------RIL-NDE--NNNNGDSKRPHLEGTPS--PSD--------------D AqueK083_Aque --------------RIL-NDE--NNNNGDSKRPHLEGTPS--PSD--------------D lok_Dmel ------------------------------------------------------------ CHK2_Mmus ------------------------------------------------------------ chk-2_Cele ------------------------------------------------------------ RAD53_Scer ------------------------------------------------------------ DUN1_Scer ------------------------------------------------------------ CHK2_Hsap ------------------------------------------------------------ T08D2.7_Cele ------------------------------------------------------------ FHAK1_Ddis ------Q----------------------------------------------------- FHAK2_Ddis -------N---------------------------------------------------- FHAK3_Ddis ------NNGNLYSKFMATNNDPFDCTPTSTPVKPITNSTTTSTATSMPTSNSVTMGTSST FHAK4_Ddis ------N----------------------------------------------------- FHAK5_Ddis ------E---------------------------------------------------TI Chk2_Spur ------------------------------------------------------------ CC1G_09319_Ccin SGSSGNRAGS-------------------------------------------------- AqueK082_Aque ------TI---------------------------------------------------- AqueK083_Aque ------TI---------------------------------------------------- lok_Dmel --------------------------------------------N--------------- CHK2_Mmus ------------------------------------------------------------ chk-2_Cele ----------------------------AP------A-------AL-------------- RAD53_Scer ---------------SQ----------IDPSKKVKRA-------KL-------------- DUN1_Scer ---------------LQ----------ITD------------------------------ CHK2_Hsap ------------------------------------------------------------ T08D2.7_Cele ----------------------------AP------A-------AL-------------- FHAK1_Ddis ---------------LQ----------LNEGELLKKR-------KTF-LSNNDQK----- FHAK2_Ddis -----------------------------------------------N----NNNNNNNN FHAK3_Ddis SIPVSNSITMKSPSILALSDDGDKKRKEKESSSSENVNDVIVIN----SNNHNNNNNNN- FHAK4_Ddis ------------------------NG-NDESKSSKKR-------QLSEDSNIND------ FHAK5_Ddis SLPVITK-NSKSMSNLQNHLNNNKINSDDESETSTNNNN----NNNNNNNNNNNNNNNN- Chk2_Spur ------------------------------------------------------------ CC1G_09319_Ccin -------S--------S-----------SNGKANKRP-------RL-------------- AqueK082_Aque ----------------S-----------IDTEPIARD-------Q--------------- AqueK083_Aque ----------------S-----------IDTEPIARD-------Q--------------- lok_Dmel -----------------------------------F------------------------ CHK2_Mmus ------------------------------------------------------------ chk-2_Cele ---------------------------------QTT------------------------ RAD53_Scer ---------------------------------DQT------------------------ DUN1_Scer ---------------------------------NKI------------------------ CHK2_Hsap ------------------------------------------------------------ T08D2.7_Cele ---------------------------------QTT------------------------ FHAK1_Ddis ----------ENI--------------------NPV------------------------ FHAK2_Ddis YYNNNINNINNNINNNI-------------NNNNNY------------------------ FHAK3_Ddis ----------HNINNGI-------------SSK--------------------------- FHAK4_Ddis ------------------------------------------------------------ FHAK5_Ddis ----NNNNKPSTINNNFPVPFPKSPTKNSPNASPPIKPQNSSNNNSGLAGIDKPKCQYDP Chk2_Spur ------------------------------------------------------------ CC1G_09319_Ccin -----------------------------------R------------------------ AqueK082_Aque -----------------------------------S------------------------ AqueK083_Aque -----------------------------------S------------------------ lok_Dmel -----------LEPPTKRSRR CHK2_Mmus ------------RLSVCGAVL chk-2_Cele -----------QAGPVKKAKM RAD53_Scer -----------SKGPENLQFS DUN1_Scer -----------PKTYSELSCL CHK2_Hsap ------------RPAVCAAVL T08D2.7_Cele ----------------QAGPV FHAK1_Ddis -----------INNPFLKSSQ FHAK2_Ddis -----------HQQYTQHTTM FHAK3_Ddis ------------PPPKRLKGS FHAK4_Ddis ------------EHEQKKVKN FHAK5_Ddis NCYRKNPQHLRDFYHTVSSNK Chk2_Spur ------------IVGRLAEGR CC1G_09319_Ccin -----------SAADDDSDYD AqueK082_Aque -----------FTSNPDTNNS AqueK083_Aque -----------FTSNPDTNNS