CLUSTAL W (1.83) multiple sequence alignment HSER_Hsap MKTLLLD----------L------------------------------------------ CG10738_Dmel MFAHPCPAPAGNYHSGLL--H--------------------------------------- CG9783_Dmel MLCCWLQ----------------------------------------------------- Gyc32E_Dmel MRDYASNVI-RSHRCLCI--F--------------------------------------- Gyc76C_Dmel MTRWPF------------------------------------------------------ CG4224_Dmel MLLV-------------------------------------------------------- CG3216_Dmel MHLL-------------------------------------------------------- KSGC_Mmus MASRTRS----------E--S--------------------------------------P HSER_Mmus MTSLLGL----------------------------------------------------- CYGX_Mmus MAGLQQG----------CH-F-------------EGQNWTA-PHWKTCLPCQ-GPWRLTV CYGF_Mmus MFLGPWP----------FSRL-------------L--SWFAI-----------------S CYGD_Mmus MSAWLLP----------AGG---------------------LPGAGFCVPARQSPSS--F ANPb_Mmus MALP-------------------------------------------------------- ANPa_Mmus MPGSRRV----------R--P--------------------------------------- odr-1_Cele MCVLRLW----------Q--M--------------------------------------- gcy-9_Cele MGPSGMI----------R--S--------------------------------------- gcy-8_Cele MRTKKAF----------L--L--------------------------------------- gcy-7_Cele MKPFYSM----------------------------------------------------- gcy-6_Cele MRSAEPR----------------------------------------------------- gcy-5_Cele MRLLYFS----------------------------------------------------- gcy-4_Cele MILFSKY----------------------------------------------------- gcy-3_Cele MKNVFQL----------------------------------------------------- gcy-27_Cele MNKLITV----------------------------------------------------- gcy-25_Cele MLLLLL------------------------------------------------------ gcy-23_Cele MPNAGFW----------S--A--------------------------------------- gcy-22_Cele MSFISKC----------------------------------------------------- gcy-21_Cele MLSAVLL----------L--L--------------------------------------- gcy-20_Cele MRILLL------------------------------------------------------ gcy-2_Cele MVSSILK----------------------------------------------------- gcy-19_Cele MEYLLFL----------------------------------------------------- gcy-18_Cele MLKTLLF----------I--L--------------------------------------- gcy-17_Cele MINRNK------------------------------------------------------ gcy-15_Cele MGLMRDC----------Y--I--------------------------------------- gcy-14_Cele MCLFLL------------------------------------------------------ gcy-13_Cele MASS-------------------------------------------------------- gcy-12_Cele MWPTSVE----------A--LRFYHTFAFSPGRRR------------------------- gcy-11_Cele MLDIMLA----------D--TKK------------------------------------- gcy-1_Cele MQIFTIL----------------------------------------------------- daf-11_Cele MGP--------------------------------------------------------- C04H5.4_Cele MLPNFWN----------F--Q--------------------------------------- CYGF_Hsap MFLGLGR----------FSRL-------------V--LWFAA-----------------F ANPb_Hsap MALP-------------------------------------------------------- ANPa_Hsap MPGPRRP-------AGSR--L--------------------------------------- CYGD_Hsap MTACARR----------AGG---------------------LPDPGLCGPAWWAPS---L T01A4.1_Cele MIDR-------------------------------------------------------- Npr1_Spur ------------------------------------------------------------ Npr2_Spur MEKM-------------------------------------------------------- Gcy3_Spur MLGGSA------------------------------------------------------ Npr3_Spur MTAI-------------------------------------------------------- Npr4_Spur MAEDAPN----------D--D--------------------------------------- Gcy1_Spur MAHARH------------------------------------------------------ Gcy2_Spur MFQYYK------------------------------------------------------ Npr5_Spur MSNAMS------------------------------------------------------ AqueK220_Aque MADSKSL----------------------------------------------------- AqueK221_Aque MIFTLL------------------------------------------------------ AqueK222_Aque MFSSGL------------------------------------------------------ HSER_Hsap ---------------AL------------WS-LLF-QP---------------------- CG10738_Dmel -------------PLLL------------LL-FLL-AF---------------------- CG9783_Dmel ---------------------------------QL------------------------- Gyc32E_Dmel -------------TVLQ------------LT-LML-SM---------------------- Gyc76C_Dmel --------------NL--------------L-LLL-SV---------------------- CG4224_Dmel -----------------------------LL--LV-GL---------------------- CG3216_Dmel ---------------GI------------SI-HFF-FL---------------------- KSGC_Mmus LEPRLYAGAGSRADHPS------------LV-LML-SV---------------------- HSER_Mmus ---------------AV------------RL-LLF-QP---------------------- CYGX_Mmus SHLKT---VSSISVLSV------------VFWSVL-LW---------------------- CYGF_Mmus SRLSGQHGLPSSKFLRC------------LC--LL-AL---------------------- CYGD_Mmus SRVLR---WPRP-GLPG------------LL--LL-LL---------------------- ANPb_Mmus ---------------SL------------LL--VV-AA---------------------- ANPa_Mmus -------------RLRA------------LL--LL-PP---------------------- odr-1_Cele --------------RRPMDSVQQSQYSEKHL-ELL-TV---------------------- gcy-9_Cele --------------EWLH----------KTS-HLL-RR---------------------- gcy-8_Cele --------------L------------------TF-NV---------------------- gcy-7_Cele ---------------SL------------VL--FL-VI---------------------- gcy-6_Cele ---------------NE------------KC--IL-NTSDASQTIQDCPLIHFHNSFPVN gcy-5_Cele ---------------MV------------LL---W--V---------------------- gcy-4_Cele ---------------YF------------SM-RQLNYY---------------------- gcy-3_Cele ---------------LI------------PL---F-FH---------------------- gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ---------------------------------LL-KI---------------------- gcy-23_Cele --------------A------------------YA-EM---------------------- gcy-22_Cele ---------------FI------------CL--LF-ST---------------------- gcy-21_Cele ----------------------------------F-FI---------------------- gcy-20_Cele ---------------------------------LL-QN---------------------- gcy-2_Cele ---------------FV------------IL---I-HS---------------------- gcy-19_Cele ---------------L-------------LF---AGFL---------------------- gcy-18_Cele --------------I------------------FF-NI---------------------- gcy-17_Cele ---------------------------------IL------------------------- gcy-15_Cele ----------------------------------Q-ST---------------------- gcy-14_Cele ---------------------------------LF-P----------------------- gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele -------------RLFG------------LS-IVF-VI---------------------- gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele -----------------------------LL---F--N---------------------- daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele --------------F------------------IF-VI---------------------- CYGF_Hsap RKLLGHHGLASAKFLWC------------LC--LL-SV---------------------- ANPb_Hsap ---------------SL------------LL--LV-AA---------------------- ANPa_Hsap -------------RLLL------------LL--LL-PP---------------------- CYGD_Hsap PRLPR----ALP-RLPL------------LL--LL-LL---------------------- T01A4.1_Cele ---------------KL------------SI---F-T----------------------- Npr1_Spur ------------------------------------------------------------ Npr2_Spur ---------------LI------------FT-SLF-SV---------------------- Gcy3_Spur ----------------P------------L------KA---------------------- Npr3_Spur ---------------LL------------AL--LL-TG---------------------- Npr4_Spur ---------------------------------MI-PS---------------------- Gcy1_Spur --------------LFL------------LL-VAF-TI---------------------- Gcy2_Spur ----------------L------------------------------------------- Npr5_Spur --------------KQS------------LL----------------------------- AqueK220_Aque ---------------PF------------SL--FF-AA---------------------- AqueK221_Aque ---------------NL------------LL--FF-SA---------------------- AqueK222_Aque --------------CY--------------H-QIG-DN---------------------- HSER_Hsap ----------G-W-L-----S----F------S-S--Q---------------------- CG10738_Dmel ----------S-N------------F---R------------------------------ CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel ----------L-E-V-----Q----I---Q--I-D--Q---------------------- Gyc76C_Dmel ----------A-V-R-----D--------------------------------------- CG4224_Dmel ------------V-F-----G----PKDCV------------------------------ CG3216_Dmel ----------M-Y-V-----N----C---F----S--A---------------------- KSGC_Mmus ----------V-M-L-----V----T---C--L-E------------------------- HSER_Mmus ----------A-L-M-----V----F---W--A-S--Q---------------------- CYGX_Mmus ------------A-D-----S--------L----S--L---------------------- CYGF_Mmus ------------L-P-----L--------L------------------------------ CYGD_Mmus ------------L-P-----S--------P------------------------------ ANPb_Mmus ------------L-A-----G----G---V------------------------------ ANPa_Mmus ------------L-L-----L--------L------------------------------ odr-1_Cele ----------I-I-L-----LKLFG-------V--------------FH----------- gcy-9_Cele ----------F-I-NPTTPNFLHFTST--YIGI-R--S------INTFL----------- gcy-8_Cele ----------L-I-Y-----L----AA-----C-Q--E------TERIL----------- gcy-7_Cele ----------T-L-L-----P----KP----------M--------------------F- gcy-6_Cele DRSLSTFCNFSFI-I-----C----DP----------G----------TRNFKLASVRFL gcy-5_Cele ----------L-G------------AS--E------------------------------ gcy-4_Cele ----------I-F-I-----S----TI--L--T-Y--N--------------------L- gcy-3_Cele ----------L-F-------S----LV--S--L-Q--N--------------------I- gcy-27_Cele --------------------IRDFS----------------------------------- gcy-25_Cele ----------S-T-F-----V--------------------------------------- gcy-23_Cele ----------P-ISK-----F----TA-----Y-A--E-------NAVM----------- gcy-22_Cele ----------Y-F-L-----P--------------------------------------- gcy-21_Cele ----------Q-N-V-----Q--------N--F-D--K---------------------- gcy-20_Cele ----------I-L-V-----F--------------------------------------- gcy-2_Cele ----------T-F-------H----ST--F--A-Q--N--------------------L- gcy-19_Cele ----------T-F-L-----P----RF--L--IYA--Q--------------------I- gcy-18_Cele ----------P-I-------I----A------I-E--E------IPDI------------ gcy-17_Cele --------------A-----N--------------------------------------- gcy-15_Cele --------------I-----L--------------------------------------- gcy-14_Cele ----------Y-L-A-----S--------------------------------------- gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele ----------A-A-L-----C----VT--S--C-D--A---------------------- gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ----------I-F-------P----SI--F--V-Q--N--------------------L- daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele ----------F-C-W-----I----PI-----V-V--S------D--------------- CYGF_Hsap ------------M-S-----L--------P------------------------------ ANPb_Hsap ------------L-A-----G----G---V------------------------------ ANPa_Hsap ------------L-L-----L----L---L------------------------------ CYGD_Hsap ------------L-Q--------------P------------------------------ T01A4.1_Cele ----------R--------------K---K----S--T---------------------- Npr1_Spur ------------------------------------------------------------ Npr2_Spur ----------I-I-I-----V----L---I----S--G---------------------- Gcy3_Spur ------------------------------------------------------------ Npr3_Spur ----------P------------------P----H--N---------------------- Npr4_Spur ----------H---T-------------------D------------------------- Gcy1_Spur ----------T-M-V-----I----A---R--L-D--F---------------------- Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque ----------F-F-I-----A----AV--Q--A-RTYRIPSYLTC--------------- AqueK221_Aque ----------C-K-A-----A---------------CTIPCYLTC--------------- AqueK222_Aque ----------V-L-F-----H--------------------------------------- HSER_Hsap --------------------V--------------------------------------- CG10738_Dmel -------------PT--------------------------------------------- CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel ------------SPE--------------------------------------------- Gyc76C_Dmel ------------------------------------------------------------ CG4224_Dmel ------------------------------------------------------------ CG3216_Dmel ------------HPNPRRNDITWDDLNKDISLDSTTSLAGLNASDAGLEQRMYERSRESK KSGC_Mmus ------------------------------------------------------------ HSER_Mmus --------------------V--------------------------------------- CYGX_Mmus ------------------------------------------------------------ CYGF_Mmus ------------------------------------------------------------ CYGD_Mmus ------------------------------------------------------------ ANPb_Mmus ------------------------------------------------------------ ANPa_Mmus ------------------------------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ---R-------------------------------------------------------- gcy-8_Cele ---A-------------------------------------------------------- gcy-7_Cele ---PQ----V-------------------------------------------------- gcy-6_Cele KYDIQ----T-------------------------------------------------- gcy-5_Cele ---------CQ------------------------------------------------- gcy-4_Cele ---T-------------------------------------------------------- gcy-3_Cele ---PV------------------------------------------------------- gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------------------------------------------------ gcy-23_Cele ---P-------------------------------------------------------- gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele ----------IEL----------------------------------------------- gcy-20_Cele ------------------------------------------------------------ gcy-2_Cele ---PD----TT------------------------------------------------- gcy-19_Cele ---TSSTTTTTPVPA--------------------------------------------- gcy-18_Cele ---K-------------------------------------------------------- gcy-17_Cele ------------------------------------------------------------ gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ------------------------------------------------------------ gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele ----------DAVPA--------------------------------------------- gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ---PD----TT------------------------------------------------- daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ------------------------------------------------------------ ANPb_Hsap ------------------------------------------------------------ ANPa_Hsap ------------------------------------------------------------ CYGD_Hsap ------------------------------------------------------------ T01A4.1_Cele ------------PPSES------------------------------------------- Npr1_Spur ------------------------------------------------------------ Npr2_Spur --------------------I--------------------------------------- Gcy3_Spur ------------------------------------------------------------ Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ------------NPT-----I--------------------------------------- Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque -------------PG--------------------------------------------- AqueK221_Aque -------------PG--------------------------------------------- AqueK222_Aque ------------------------------------------------------------ HSER_Hsap ------------S--------------------------------------Q-------- CG10738_Dmel ------------------------------------------------------------ CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel ------------------------------------------------------------ Gyc76C_Dmel ------------------------------------------------------------ CG4224_Dmel ------------A----------------------------------------------- CG3216_Dmel STQLSRYTEVGEM----------------------------------------------- KSGC_Mmus ------------------------------------------------------------ HSER_Mmus ------------R--------------------------------------Q-------- CYGX_Mmus ------------L----------------------------------------------- CYGF_Mmus ------------R----------------------------------------------- CYGD_Mmus ------------------------------------------------------------ ANPb_Mmus ------------R----------------------------------------------- ANPa_Mmus ------------R----------------------------------------------- odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ------------R--------------------------------------DCSNRS--- gcy-8_Cele ------------N--------------------------------------NGTEDNEIT gcy-7_Cele ---------------------------------------------------A-------- gcy-6_Cele ---------------------------------------------------I-------- gcy-5_Cele ---------------------------------------------------V-------- gcy-4_Cele ---------------------------------------------------H-------- gcy-3_Cele ---------------------------------------------------S-------- gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------------------------------------------------ gcy-23_Cele ------------K--------------------------------------NSECRTGIS gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele ------------E----------------------------------------------- gcy-20_Cele ------------------------------------------------------------ gcy-2_Cele ---------------------------------------------------V-------- gcy-19_Cele ------------A-NRRTVGLRDFFTGPNFFMKIFTAKFEFYVFFLVYSGIF-------- gcy-18_Cele ------------E--------------------------------------NGEKSSYTQ gcy-17_Cele ------------------------------------------------------------ gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ------------------------------------------------------------ gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele ------------P----------------------------------------------- gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ---------------------------------------------------V-------- daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ------------Q----------------------------------------------- ANPb_Hsap ------------R----------------------------------------------- ANPa_Hsap ------------R----------------------------------------------- CYGD_Hsap ------------------------------------------------------------ T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------T----------------------------------------------- Gcy3_Spur ------------------------------------------------------------ Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ------------I--------------------------------------N-------- Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque ------------IND------------------------------------T-------- AqueK221_Aque ------------VNE------------------------------------T-------- AqueK222_Aque ------------------------------------------------------------ HSER_Hsap ----------------------------------------N--------------C---- CG10738_Dmel ------------------------------------------------------------ CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel ------------------------------------------------------------ Gyc76C_Dmel ---------------------------------------CS--------------N---- CG4224_Dmel ----------------------------------------TCREEPARDCEAICDA---- CG3216_Dmel ----------------------------------------G--------------S---- KSGC_Mmus ------------------------------------------------------------ HSER_Mmus ----------------------------------------N--------------C---- CYGX_Mmus ----------------------------------------A--------------W---- CYGF_Mmus ----------------------------------------W--------------G---- CYGD_Mmus ----------------------------------------S--------------A---- ANPb_Mmus ----------------------------------------P--------------P---- ANPa_Mmus ----------------------------------------S--------------G---- odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ----PSP---------------HE-PYYS-----------T--------------R---- gcy-8_Cele TSKGVSPN--------------TN-PLFLSN--STAGLYDS--------------K---- gcy-7_Cele ---------------------------------------TG--------------T---- gcy-6_Cele ---------------------------------------CQ--------------P---- gcy-5_Cele ---------------------------------------IP--------------S---- gcy-4_Cele ---------------------------------------GQ--------------G---- gcy-3_Cele ---------------------------------------TG--------------T---- gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------------------------------------------------ gcy-23_Cele LSIGSYHEISEEGFKIWDNPTGVGPPLRLIAKIYTHFFAFR--------------Y---- gcy-22_Cele ----------------------------------------P--------------V---- gcy-21_Cele ----------------------------------------D-----------------IT gcy-20_Cele ----------------------------------------C--------------Q---- gcy-2_Cele ---------------------------------------AP--------------K---- gcy-19_Cele ---------------------------------------SS--------------K---- gcy-18_Cele FDNGAKLEV------------------------------NK--------------E---- gcy-17_Cele ----------------------------------------C--------------Q---- gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ----------------------------------------G--------------Q---- gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele ----------------------------------------SP-------------EAEPS gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ---------------------------------------AP--------------R---- daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ----------------------------------------Q--------------V---- ANPb_Hsap ----------------------------------------P--------------P---- ANPa_Hsap ----------------------------------------G--------------S---- CYGD_Hsap ----------------------------------------P--------------A---- T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ----------------------------------------T--------------A---- Gcy3_Spur ------------------------------------------------------------ Npr3_Spur ------------------------------------------------------------ Npr4_Spur ----------------------------------------Q--------------T---- Gcy1_Spur ---------------------------------------ED--------------R---- Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque ---------------------------------------DA--------------D---- AqueK221_Aque -------------------------------------------------------G---- AqueK222_Aque ---------------------------------------CW--------------W---- HSER_Hsap ---------------------HNG------------------------------------ CG10738_Dmel ---------------------HGE------------------------------------ CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel ---------------------LQRPMTRVLLGAQLGELAWSPLFSGFAMGAMFYGYGLIH Gyc76C_Dmel ---------------------HRT------------------------------------ CG4224_Dmel ---------------------NGR------------------------------------ CG3216_Dmel ---------------------TMR------------------------------------ KSGC_Mmus ----------------------AA------------------------------------ HSER_Mmus ---------------------RNG------------------------------------ CYGX_Mmus ---------------------ARE------------------------------------ CYGF_Mmus ---------------------QAL------------------------------------ CYGD_Mmus ---------------------LSA------------------------------------ ANPb_Mmus ---------------------GAR------------------------------------ ANPa_Mmus ---------------------HAS------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ---------------------TRC------------------------------------ gcy-8_Cele ---------------------GRI------------------------------------ gcy-7_Cele ---------------------TGN------------------------------------ gcy-6_Cele ---------------------PGN------------------------------------ gcy-5_Cele ---------------------SRR------------------------------------ gcy-4_Cele ---------------------PRP------------------------------------ gcy-3_Cele ---------------------TRP------------------------------------ gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele -----------------------D------------------------------------ gcy-23_Cele ---------------------FQC------------------------------------ gcy-22_Cele ---------------------NSA------------------------------------ gcy-21_Cele VY--------------F------------------------------------------- gcy-20_Cele ---------------------FLQ------------------------------------ gcy-2_Cele ---------------------TKR------------------------------------ gcy-19_Cele ---------------------FEN------------------------------------ gcy-18_Cele ---------------------HKR------------------------------------ gcy-17_Cele ---------------------ARR------------------------------------ gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ---------------------FLQ------------------------------------ gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele LGAGANPYLLDSLVKRLPKKGDKK------------------------------------ gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ---------------------TKR------------------------------------ daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele ---------------------EKI------------------------------------ CYGF_Hsap ---------------------WTL------------------------------------ ANPb_Hsap ---------------------GAR------------------------------------ ANPa_Hsap ---------------------HAG------------------------------------ CYGD_Hsap ---------------------LSA------------------------------------ T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ---------------------GFS------------------------------------ Gcy3_Spur ------------------------------------------------------------ Npr3_Spur ------------------------------------------------------------ Npr4_Spur ---------------------KNR------------------------------------ Gcy1_Spur ---------------------GRT------------------------------------ Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque ---------------------AKP------------------------------------ AqueK221_Aque ---------------------SKL------------------------------------ AqueK222_Aque ---------------------GN------------------------------------- HSER_Hsap ------------------------------------------------------------ CG10738_Dmel ------------------------------------------------------------ CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel LPSKGPLGCFFSRLRTAGLSVWQQCSPVMLVPWTLKVAQGLSLFPCHLWEFLANEVCLET Gyc76C_Dmel ------------------------------------------------------------ CG4224_Dmel ------------------------------------------------------------ CG3216_Dmel ------------------------------------------------------------ KSGC_Mmus ------------------------------------------------------------ HSER_Mmus ------------------------------------------------------------ CYGX_Mmus ------------------------------------------------------------ CYGF_Mmus ------------------------------------------------------------ CYGD_Mmus ------------------------------------------------------------ ANPb_Mmus ------------------------------------------------------------ ANPa_Mmus ------------------------------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ------------------------------------------------------------ gcy-8_Cele ------------------------------------------------------------ gcy-7_Cele ------------------------------------------------------------ gcy-6_Cele ------------------------------------------------------------ gcy-5_Cele ------------------------------------------------------------ gcy-4_Cele ------------------------------------------------------------ gcy-3_Cele ------------------------------------------------------------ gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------------------------------------------------ gcy-23_Cele ------------------------------------------------------------ gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele ------------------------------------------------------------ gcy-20_Cele ------------------------------------------------------------ gcy-2_Cele ------------------------------------------------------------ gcy-19_Cele ------------------------------------------------------------ gcy-18_Cele ------------------------------------------------------------ gcy-17_Cele ------------------------------------------------------------ gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ------------------------------------------------------------ gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele ------------------------------------------------------------ gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ------------------------------------------------------------ daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ------------------------------------------------------------ ANPb_Hsap ------------------------------------------------------------ ANPa_Hsap ------------------------------------------------------------ CYGD_Hsap ------------------------------------------------------------ T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------------------------------------------ Gcy3_Spur ------------------------------------------------------------ Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ------------------------------------------------------------ Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------------------------ AqueK222_Aque ------------------------------------------------------------ HSER_Hsap ---------------------------SYEI--SVLMMG-----N--------------S CG10738_Dmel ---------------------------VFTL--GYLTAS----QR--------------R CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel DNCLQHVILAFVLWIYLLILAITSLVSVVRL--NLQMLA----DR--------------H Gyc76C_Dmel ---------------------------VLTV--GYLTAL----TG--------------D CG4224_Dmel ---------------------------NCTIRALVLLPD----D---------------N CG3216_Dmel ---------------------------VYNV--GVLMAS----H---------------L KSGC_Mmus ---------------------------KLTV--GFHAPW-----N--------------I HSER_Mmus ---------------------------SYEI--SVLMMD-----N--------------S CYGX_Mmus ---------------------------TFTL--GVLGPW----DC--------------- CYGF_Mmus ---------------------------PYKI--GVIGPW----TC--------------- CYGD_Mmus ---------------------------VFKV--GVLGPW----AC--------------- ANPb_Mmus ---------------------------NLTL--AVVLPE----HN--------------L ANPa_Mmus ---------------------------DLTV--AVVLPL----TN--------------T odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ---------------------------SKNV--R--RRF----EN--------------- gcy-8_Cele ---------------------------RLTI--GHIGAI----GA--------------- gcy-7_Cele ---------------------------VIRV--GFIHCR----DF--------------Q gcy-6_Cele ---------------------------VFHL--GFLHCDVLENNV--------------E gcy-5_Cele ---------------------------TLRV--GIAAAQ----DT--------------Q gcy-4_Cele ---------------------------VIRV--GITAAL----KT--------------E gcy-3_Cele ---------------------------KLKV--GIAAAQ----KT--------------Q gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ---------------------------SFQI--GHLEFE----NS--------------N gcy-23_Cele ---------------------------VVKV--GHIGAV----GS--------------- gcy-22_Cele ---------------------------VLQV--GFLAAN----DN--------------T gcy-21_Cele ---------------------------PLKV--DYLAP---------------------- gcy-20_Cele ---------------------------TIKV--GLMFSK----DT--------------A gcy-2_Cele ---------------------------TIKI--GIAAAQ----RT--------------Q gcy-19_Cele ---------------------------RIRV--GVAAVQ----TT--------------E gcy-18_Cele ---------------------------VIKI--GHIGAV----GV--------------- gcy-17_Cele ---------------------------TIKV--GLLFVQ----NV--------------S gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ---------------------------TVKV--GLLFSK----DT--------------A gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele ---------------------------EILI--SYLAAV----PTLMGEIDQYLLNLSAS gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ---------------------------TIKI--GIAAAQ----RI--------------Q daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele ---------------------------VLKI--GSISSR----DN--------------- CYGF_Hsap ---------------------------PYKI--GVVGPW----AC--------------- ANPb_Hsap ---------------------------NLTL--AVVLPE----HN--------------L ANPa_Hsap ---------------------------NLTV--AVVLPL----AN--------------T CYGD_Hsap ---------------------------VFTV--GVLGPW----AC--------------- T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ---------------------------SCT-DLHLL-MI----HG--------------T Gcy3_Spur ------------------------------------------------------------ Npr3_Spur ------------------------------------------------------------ Npr4_Spur ---------------------------AIKT--IILH-R----AC--------------Q Gcy1_Spur ---------------------------KIHV--GLLAEW----TT--------------A Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque ---------------------------QVRI--GVMFDF----PL--------------L AqueK221_Aque ---------------------------QVRI--GVILDF----PS--------------N AqueK222_Aque ----------------------------ASV--SNPDPI----DC--------------H HSER_Hsap ------------------------A----FAEPLKNLED--------------AVNEGLE CG10738_Dmel ------------------------PGNLDYNRPGLTISG--------------AI----S CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel ------------------------IHSRDHELRAYVTLG--------------GL----P Gyc76C_Dmel ------------------------L----KTRQGLAISG--------------AL----T CG4224_Dmel ------------------------M----YQASLPRVLP--------------IL----K CG3216_Dmel ------------------------D----SPFDLERCGP--------------AV----D KSGC_Mmus ------------------------S----HPFSVQRLGA--------------GL----Q HSER_Mmus ------------------------A----YKEPMQNLRE--------------AVEEGLD CYGX_Mmus ------------------------D----PIFAQALPSI--------------AT----Q CYGF_Mmus ------------------------D----PFFSKALPEV--------------AA----A CYGD_Mmus ------------------------D----PIFARARPDL--------------AA----R ANPb_Mmus ------------------------S----YAWAWPRVGP--------------AV----A ANPa_Mmus ------------------------S----YPWSWARVGP--------------AV----E odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ---------------------------------EKYSST--------------KL----Y gcy-8_Cele ---------------------------------LRNDVK--------------IL----E gcy-7_Cele ------------------------S--APITVGYRTSAA--------------AA----S gcy-6_Cele ------------------------G--STTYINYRTSAS--------------AA----S gcy-5_Cele ------------------------S----GSIGWASCGG--------------TL----P gcy-4_Cele ------------------------N----GSIGWAYTGG--------------AV----P gcy-3_Cele ------------------------S----ASIGWNVCGG--------------AV----P gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------------E----T--------R--------------IL----E gcy-23_Cele ---------------------------------MRNAEK--------------IL----Q gcy-22_Cele ------------------------T-ELAPFIGWGQVAG--------------AL----G gcy-21_Cele ------------------------------------------------------------ gcy-20_Cele ------------------------S--VIRSVGYRTSAA--------------AV----L gcy-2_Cele ------------------------T----SSIGWSVCGG--------------AV----P gcy-19_Cele ------------------------L----DSIGWPMSGG--------------AI----N gcy-18_Cele ---------------------------------MPNDAR--------------IL----N gcy-17_Cele ------------------------S--LQVGIGYRTSAA--------------AV----L gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ------------------------S--VMRAVGYRTSAA--------------AV----L gcy-13_Cele -------------------------------VGWQTSAS--------------AI----E gcy-12_Cele NSAQNSSKDRESFSKKLNQIVHCLT----TDAYVSVVSG--------------AL----V gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ------------------------T----SSIGWSVCGG--------------AV----P daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele ---------------------------------AKMLES--------------IL----E CYGF_Hsap ------------------------D----SLFSKALPEV--------------AA----R ANPb_Hsap ------------------------S----YAWAWPRVGP--------------AV----A ANPa_Hsap ------------------------S----YPWSWARVGP--------------AV----E CYGD_Hsap ------------------------D----PIFSRARPDL--------------AA----R T01A4.1_Cele ----------------------------------QKNGG--------------LT----P Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------Y----GLMSYQYNDP--------------AI----D Gcy3_Spur ------------------------------------------------------------ Npr3_Spur -------------------------------LNEIHLRP--------------AI----D Npr4_Spur -----------------------------YSVDHRSILV--------------RS----S Gcy1_Spur ------------------------DG--DQGTLGFPALG--------------AL----P Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque ------------------------P----NETQVYEEAGLEPGDVLPGKLLIPYS----P AqueK221_Aque ------------------------A----NETKLLQSAGLNPEDLLPGDMLLPYS----P AqueK222_Aque -----------------------------DISLAWNE----------------------- HSER_Hsap IVR------GRLQNAG--LN-V-TVN-A-------------------------------- CG10738_Dmel LAV------EEVNAGR--LRDR-GHS-L-------------------------------- CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel LAI------EDVNKNP--NLLP-GKK-L-------------------------------- Gyc76C_Dmel MAL------DEVNKDP--NLLP-NVY-L-------------------------------- CG4224_Dmel VAE------QQIRSK---SLIPSHID-F-------------------------------- CG3216_Dmel LAL------DEINKV----FLKP-HN-I-------------------------------- KSGC_Mmus TVV------DKLNSEP--VGLG-NVS-W-------------------------------- HSER_Mmus IVR------KRLREAD--LN-V-TVN-A-------------------------------- CYGX_Mmus LAV------DQVNQDA--SLLP-GSQ-L-------------------------------- CYGF_Mmus LAI------ERISRDK--TFDR-SYS-F-------------------------------- CYGD_Mmus LAA------NRLNRDF--ALDG-GPR-F-------------------------------- ANPb_Mmus LAV------EALGRA----L---PVD-L-------------------------------- ANPa_Mmus LAL------GRVKARP--DLLP-GWT-V-------------------------------- odr-1_Cele ----------RINQ---------------------------------------------- gcy-9_Cele FNV------RSLNLK---K--TSLSN-F-------------------------------- gcy-8_Cele VSH------KALQAE---GILDDDLD-V-------------------------------- gcy-7_Cele IAV------DRLKRE---NLMS-GWE-F-------------------------------- gcy-6_Cele IAI------DKIKRE---GLLL-GYD-F-------------------------------- gcy-5_Cele IAV------QYLKSK---GFLT-DFD-V-------------------------------- gcy-4_Cele LAL------QYLKSH---GYML-NFD-F-------------------------------- gcy-3_Cele LAI------ERLKQA---GYVT-NFD-F-------------------------------- gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ICM------K---NA---G---SWRD-H-------------------------------- gcy-23_Cele LSK------EQLTQE---GVLGNDFD-I-------------------------------- gcy-22_Cele VAW------SRIVEY---GLLP-GYETM-------------------------------- gcy-21_Cele ---------------F--GC---------------------------------------- gcy-20_Cele VAK------DRIRAE---HLLD-QYD-F-------------------------------- gcy-2_Cele MAI------ERLREF---GYVK-DFD-F-------------------------------- gcy-19_Cele MAI------QKLRDD---GFIA-PFD-F-------------------------------- gcy-18_Cele ISK------ENLIEE---GLVGDDIE-F-------------------------------- gcy-17_Cele VTK------NKIRED---HVLD-GFD-FEKLRNVLKFSTKFQNIPDFFSSALKWPRKFYI gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele VAR------DRIRAE---HLLD-QYD-F-------------------------------- gcy-13_Cele IAM------DRIKSE---HLID-NIG-I-------------------------------- gcy-12_Cele AAI------VEINQDK--DLIP-AYQ-L-------------------------------- gcy-11_Cele --------------N--------------------------------------------- gcy-1_Cele LAI------ERLKEM---GFVK-DFD-F-------------------------------- daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele MAK------KKMTEQ---GVLGEKLD-I-------------------------------- CYGF_Hsap LAI------ERINRDP--SFDL-SYS-F-------------------------------- ANPb_Hsap LAV------EALGRA----L---PVD-L-------------------------------- ANPa_Hsap LAL------AQVKARP--DLLP-GWT-V-------------------------------- CYGD_Hsap LAA------ARLNRDP--GLAG-GPR-F-------------------------------- T01A4.1_Cele NSL------QKAE----------------------------------------------- Npr1_Spur ------------------------------------------------------------ Npr2_Spur IAV------EEIRRRVTEGEYV-NIS-L-------------------------------- Gcy3_Spur --S------D-------------------------------------------------- Npr3_Spur IAF------EKVNNGAARGLYL-NFS-M-------------------------------- Npr4_Spur LSW------HRLDNTA---F---------------------------------------- Gcy1_Spur LAI------SLANQDS--NILN-GFD-V-------------------------------- Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque LAVSAYKQAVKINANP--AILP-YHH-L-------------------------------- AqueK221_Aque LALITYETAKRLNLNS--TVLP-EHY-I-------------------------------- AqueK222_Aque ----------EPPSEV--RVGQ-RFN-V-------------------------------- HSER_Hsap ------------------------------------------------------------ CG10738_Dmel ------------------------------------------------------------ CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel ------------------------------------------------------------ Gyc76C_Dmel ------------------------------------------------------------ CG4224_Dmel ------------------------------------------------------------ CG3216_Dmel ------------------------------------------------------------ KSGC_Mmus ------------------------------------------------------------ HSER_Mmus ------------------------------------------------------------ CYGX_Mmus ------------------------------------------------------------ CYGF_Mmus ------------------------------------------------------------ CYGD_Mmus ------------------------------------------------------------ ANPb_Mmus ------------------------------------------------------------ ANPa_Mmus ------------------------------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ------------------------------------------------------------ gcy-8_Cele ------------------------------------------------------------ gcy-7_Cele ------------------------------------------------------------ gcy-6_Cele ------------------------------------------------------------ gcy-5_Cele ------------------------------------------------------------ gcy-4_Cele ------------------------------------------------------------ gcy-3_Cele ------------------------------------------------------------ gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------------------------------------------------ gcy-23_Cele ------------------------------------------------------------ gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele ------------------------------------------------------------ gcy-20_Cele ------------------------------------------------------------ gcy-2_Cele ------------------------------------------------------------ gcy-19_Cele ------------------------------------------------------------ gcy-18_Cele ------------------------------------------------------------ gcy-17_Cele ISEVLNFLEVLKMLENFFRIFQKISEVSRIFSNFPEISRRFLNCSQIFQQFPEVFRFFKE gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ------------------------------------------------------------ gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele ------------------------------------------------------------ gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ------------------------------------------------------------ daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ------------------------------------------------------------ ANPb_Hsap ------------------------------------------------------------ ANPa_Hsap ------------------------------------------------------------ CYGD_Hsap ------------------------------------------------------------ T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------------------------------------------ Gcy3_Spur ------------------------------------------------------------ Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ------------------------------------------------------------ Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------------------------ AqueK222_Aque ------------------------------------------------------------ HSER_Hsap ------------------------------------------------------TFMYSD CG10738_Dmel ------------------------------------------------------QFVVAE CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel ------------------------------------------------------AFKPVD Gyc76C_Dmel ------------------------------------------------------DLRWND CG4224_Dmel ------------------------------------------------------EWLAH- CG3216_Dmel ------------------------------------------------------TLLKKK KSGC_Mmus ------------------------------------------------------EFTY-- HSER_Mmus ------------------------------------------------------TFIYSD CYGX_Mmus ------------------------------------------------------DFKVL- CYGF_Mmus ------------------------------------------------------EYVIL- CYGD_Mmus ------------------------------------------------------EVALL- ANPb_Mmus ------------------------------------------------------RFVSSE ANPa_Mmus ------------------------------------------------------RMVLGS odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ------------------------------------------------------SVF-T- gcy-8_Cele ------------------------------------------------------EII-S- gcy-7_Cele ------------------------------------------------------NFTIE- gcy-6_Cele ------------------------------------------------------KFTIL- gcy-5_Cele ------------------------------------------------------EYYME- gcy-4_Cele ------------------------------------------------------EFHVE- gcy-3_Cele ------------------------------------------------------EYYVE- gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------------------------------------------R-LIS- gcy-23_Cele ------------------------------------------------------EIL-N- gcy-22_Cele ------------------------------------------------------NLTWV- gcy-21_Cele --------------------------------------------------------ATG- gcy-20_Cele ------------------------------------------------------NFTIK- gcy-2_Cele ------------------------------------------------------EFIVD- gcy-19_Cele ------------------------------------------------------EVTVN- gcy-18_Cele ------------------------------------------------------EIV-S- gcy-17_Cele FSESSQKTFPEVSRIFSNISGVSKRLRNYFKFSEVSKKFSGGSKNVSNISKVSRRFLWD- gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ------------------------------------------------------NFTVK- gcy-13_Cele ------------------------------------------------------NFIYV- gcy-12_Cele ------------------------------------------------------KYVFG- gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ------------------------------------------------------EYIVD- daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele ------------------------------------------------------QII-T- CYGF_Hsap ------------------------------------------------------EYVIL- ANPb_Hsap ------------------------------------------------------RFVSSE ANPa_Hsap ------------------------------------------------------RTVLGS CYGD_Hsap ------------------------------------------------------EVALL- T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------------------------------------T--LED Gcy3_Spur ------------------------------------------------------------ Npr3_Spur ------------------------------------------------------SYVFRE Npr4_Spur ------------------------------------------------------H----- Gcy1_Spur ------------------------------------------------------QFEWVD Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque ------------------------------------------------------CLYFTF AqueK221_Aque ------------------------------------------------------CLYYTF AqueK222_Aque ------------------------------------------------------SYHIEA HSER_Hsap GLIHNSGDCRSS------TCEGL----------------------DLLRKISNAQRMGCV CG10738_Dmel ------TYGE-E-------VVSI----------------------RQTAA-LWTQ-QVAA CG9783_Dmel ----------------------------------------------------------QE Gyc32E_Dmel ---IGHKMSAYR-------VKPL----------------------RAMTQ-MREA-GVTA Gyc76C_Dmel ------TKGD-T-------VLAT----------------------KAITE-MICD-GIAT CG4224_Dmel -----DTKCDA--------SLGV----------------------IKAMDGIIKQ-CAQV CG3216_Dmel ---GSYPSCSG--------ARAP----------------------GLAADMYFQD-DVIA KSGC_Mmus ----TNSTCSAK------E--SL----------------------AVFIDQVQKE-HISA HSER_Mmus GLIHKSGDCRSS------TCEGL----------------------DLLREITRDHKMGCA CYGX_Mmus -----PTGCDT--------PHAL----------------------ATF--VAHKN-IVAA CYGF_Mmus -----NEDCQT--------SKAL----------------------ASF--ISHQQ-MASG CYGD_Mmus -----PEPCLT--------PGSL----------------------GAV--SSALS-RVSG ANPb_Mmus ----LDGACSE--------YLAP----------------------LRAVDLKLYH-DPDL ANPa_Mmus -SENAAGVCSD--------TAAP----------------------LAAVDLKWEH-SPAV odr-1_Cele -----QHGCSGD-NSVKSASYAI----------------------NAVASRTSGE-LDFV gcy-9_Cele -----MESCNKY--------SGV----------------------EHAAFLHYLK-NASV gcy-8_Cele -----QTGCGES-------YEGV----------------------AVAADMYHLQ-KVKA gcy-7_Cele -----FDDCVE--------SEAA----------------------GMTVDLIEKH-NVDV gcy-6_Cele -----YDQCDE--------NIAA----------------------GNAIKLFAEH-NVDV gcy-5_Cele -----YTECDR--------ASVA----------------------KAGMKFMKEM-NVDV gcy-4_Cele -----YTECDL--------ANTV----------------------RAGLNFMKTN-NYDV gcy-3_Cele -----YTECDL--------ASTV----------------------RTGINFLKNL-EVDV gcy-27_Cele ----------------------------------------------------------Y- gcy-25_Cele -----LPSCHN--------FNGL----------------------ENAANLNYQY-SVDL gcy-23_Cele -----QMGCGES-------YEGV----------------------AVGADMYHVQ-GVRA gcy-22_Cele -----LTNCRE--------ADAV----------------------GSVINY-AEG-HAHV gcy-21_Cele ------TKCDDE-------A-AL----------------------NN---------GTIA gcy-20_Cele -----FDECSE--------SLAA----------------------GKVVELLTHD-NVDV gcy-2_Cele -----YTECDQ--------GSVV----------------------RAGIEFIKTH-KVDV gcy-19_Cele -----YTECDR--------SLGA----------------------AVGMEFMRTK-RLDV gcy-18_Cele -----RQACSES-------FEGV----------------------AVAAELYHVH-QVRA gcy-17_Cele -----FDECNE--------ILGA----------------------GKTVDLLEVK-KVDV gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele -----FDECTE--------GLAG----------------------GKTVELINHD-NVDV gcy-13_Cele -----FDDCNE--------AKAA----------------------GLSSKLLMDA-NVSA gcy-12_Cele ------NTCGND-------SHST----------------------RLFME-HWQA-GARV gcy-11_Cele ------------------------------------------------------D-GLLG gcy-1_Cele -----YTECDL--------GSVV----------------------RAGMEFIKTH-KVDV daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele -----VEGCGAS-------FEGV----------------------AAAAELYHVQ-KVDA CYGF_Hsap -----NEDCQT--------SRAL----------------------SSF--ISHHQ-MASG ANPb_Hsap ----LEGACSE--------YLAP----------------------LSAVDLKLYH-DPDL ANPa_Hsap -SENALGVCSD--------TAAP----------------------LAAVDLKWEH-NPAV CYGD_Hsap -----PEPCRT--------PGSL----------------------GAV--SSALA-RVSG T01A4.1_Cele -----NGDCSP------------------------------------------------- Npr1_Spur ------------------------------------------------------------ Npr2_Spur ----VTIRCFGG------ERQAG----------------------AIFAETYFKR-PLAA Gcy3_Spur ------------------------------------------------------------ Npr3_Spur ----TGPDCGRP------VMEAP----------------------AIAAELYRRY-SLDG Npr4_Spur --------CW-------------------------------------------------P Gcy1_Spur ------THCD-I-------NIGM----------------------HAVSD-WWKR-GFVG Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque ----T--PVDFLDI-----RLGSNYIFVHSRVRQVVNALYDMKQHLSHAELMVHY-SPLI AqueK221_Aque ----V-----------------------------------------------PQG-FRNI AqueK222_Aque ------TD---------------------------------------------------- HSER_Hsap LIGPSCTY----------------------STFQM-YLDTE------------------- CG10738_Dmel YIGPQETC------------------------VHEGRMAAA------------------- CG9783_Dmel FGGPEVDK----------------------PDLLKGSIGSL------------------- Gyc32E_Dmel FIGPDESC------------------------TTEALLASA------------------- Gyc76C_Dmel IFGPEGPC------------------------YVEAIVSQS------------------- CG4224_Dmel IFGPVCDY------------SLVFGLPCEYVLAPISRYADV------------------- CG3216_Dmel FIGPACAF----------------------ALEPVARLAAY------------------- KSGC_Mmus LFGPACPE----------------------AAEVIGLLASE------------------- HSER_Mmus LMGPSCTY----------------------STFQM-YLDTE------------------- CYGX_Mmus FVGPVNPG----------------------FCSAAALLAQG------------------- CYGF_Mmus FVGPANPG----------------------FCEAASLLGTS------------------- CYGD_Mmus LVGPVNPA----------------------ACRPAELLAQE------------------- ANPb_Mmus LLGPGCVY----------------------PAASVARFASH------------------- ANPa_Mmus FLGPGCVY----------------------SAAPVGRFTAH------------------- odr-1_Cele FVGPTCTT----------------------DIRTIGDFAEI------------------- gcy-9_Cele YFGPGCNN----------------------EMLVIGRLAPR------------------- gcy-8_Cele FIGPYCNA----------------------EMDAVARMAAF------------------- gcy-7_Cele IIGPTMNQ----------------------PTLAAFIVSNY------------------- gcy-6_Cele LFGPTTNN----------------------AAMPVFILATY------------------- gcy-5_Cele VVGPSCGD----------------------ALAIMGTLSAI------------------- gcy-4_Cele IIGPPCAP----------------------ALKMMGTLSTI------------------- gcy-3_Cele IIGPPCSE----------------------AIRTMATLATL------------------- gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele LIGAACDE----------------------ETQTVSRLALR------------------- gcy-23_Cele FIGPYCNA----------------------ELDAVAKMATF------------------- gcy-22_Cele VLGPPCVR----------------------PAQVAGSVAKY------------------- gcy-21_Cele ALGLMRDC------------------------YIQSTILNI------------------- gcy-20_Cele IIGPTCNR----------------------AGVAVASLADF------------------- gcy-2_Cele IIGPPCAQ----------------------ALRVMSFLAEN------------------- gcy-19_Cele VIGPPCRDRKSLSFRASSQFI-------ISAMEIMATMATY------------------- gcy-18_Cele FIGPYCAA----------------------ELEAVTKMATF------------------- gcy-17_Cele IFGPTCSR----------------------PALISSALATY------------------- gcy-15_Cele ---------------------------------------NI------------------- gcy-14_Cele IIGPTCNR----------------------AGIAVASLAAY------------------- gcy-13_Cele IVGPTCNA----------------------AGLAVVNLAGY------------------- gcy-12_Cele FIGPEKNC------------------------KTEAAMAAS------------------- gcy-11_Cele VVGVENDC------------------------KEIAALAQA------------------- gcy-1_Cele IIGPPCAQ----------------------ALRLMSFLAEN------------------- daf-11_Cele ----TCSS----------------------NFLRFANLTAE------------------- C04H5.4_Cele YFGPYCSK----------------------ELSPVATMASY------------------- CYGF_Hsap FIGPTNPG----------------------YCEAASLLGNS------------------- ANPb_Hsap LLGPGCVY----------------------PAASVARFASH------------------- ANPa_Hsap FLGPGCVY----------------------AAAPVGRFTAH------------------- CYGD_Hsap LVGPVNPA----------------------ACRPAELLAEE------------------- T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur IMGPPCSN----------------------QMHSVAELAAA------------------- Gcy3_Spur ------------------------------------------------------------ Npr3_Spur ILGSPCSY----------------------ETVGIADLAAY------------------- Npr4_Spur LNGPDETN----------------------YEADCQGFHMGWSEQPPLEVKSGDTFEVHY Gcy1_Spur VIGPGCGC------------------------TYEGRLASA------------------- Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque TIGHSLST----------------------NICPDASLSTL------------------- AqueK221_Aque ALGPTRTY----------------------SHQGVYLMINA------------------- AqueK222_Aque ----------------------------------------D------------------- HSER_Hsap ---LSYPMISAG---------------------------------------S-------- CG10738_Dmel ---FNLPMISYY---------------------------------------C-------- CG9783_Dmel ---KNLGFVIPG---------------------------------------A-------- Gyc32E_Dmel ---WNTPMLSFK---------------------------------------C-------- Gyc76C_Dmel ---RNIPMISYK---------------------------------------C-------- CG4224_Dmel ---WQVPVLTTG---------------------------------------G-------- CG3216_Dmel ---WNKPIITGM---------------------------------------GDQPPSSEG KSGC_Mmus ---WNIPLFDFV---------------------------------------G-------- HSER_Mmus ---LNYPMISAG---------------------------------------S-------- CYGX_Mmus ---WGKSLFSWA---------------------------------------C-------- CYGF_Mmus ---WDKGIFSWA---------------------------------------C-------- CYGD_Mmus ---AGVALVPWG---------------------------------------C-------- ANPb_Mmus ---WRLPLLTAG---------------------------------------A-------- ANPa_Mmus ---WRVPLLTAG---------------------------------------A-------- odr-1_Cele ---WKSPVIGYE---------------------------------------P-------- gcy-9_Cele ---WNVPIIAHM---------------------------------------S-------- gcy-8_Cele ---WNIPIIGYM---------------------------------------A-------- gcy-7_Cele ---FNRPIIAWG---------------------------------------L-------- gcy-6_Cele ---YNIPLITWG---------------------------------------I-------- gcy-5_Cele ---YKKLVLGWG---------------------------------------F-------- gcy-4_Cele ---YKKPVLGWG---------------------------------------F-------- gcy-3_Cele ---YKKPVLGWG---------------------------------------F-------- gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ---WHKLYLSS------------------------------------------------- gcy-23_Cele ---WNIPVVGYM---------------------------------------A-------- gcy-22_Cele ---LDFPLILWG---------------------------------------P-------- gcy-21_Cele ---NSKIAVSDV---------------------------------------C-------- gcy-20_Cele ---YNVPVFQWG---------------------------------------L-------- gcy-2_Cele ---YKKPVLGWG---------------------------------------F-------- gcy-19_Cele ---YSTPMLGWG---------------------------------------L-------- gcy-18_Cele ---WNIPIISYS---------------------------------------S-------- gcy-17_Cele ---YNIPIFEWG---------------------------------------L-------- gcy-15_Cele ---NLKIAVSDV---------------------------------------C-------- gcy-14_Cele ---YNVPVFQWG---------------------------------------L-------- gcy-13_Cele ---YNTPVLTWG---------------------------------------L-------- gcy-12_Cele ---QNLPIISYR---------------------------------------C-------- gcy-11_Cele ---YDASSLLVN---------------------------------------C-------- gcy-1_Cele ---YKKPVLGWG---------------------------------------F-------- daf-11_Cele ---MQSLEINI------------------------------------------------- C04H5.4_Cele ---WNIPIFAYT---------------------------------------A-------- CYGF_Hsap ---WDKGIFSWA---------------------------------------C-------- ANPb_Hsap ---WRLPLLTAG---------------------------------------A-------- ANPa_Hsap ---WRVPLLTAG---------------------------------------A-------- CYGD_Hsap ---AGIALVPWG---------------------------------------C-------- T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ---WDIPVLSGL---------------------------------------S-------- Gcy3_Spur ------EVASRT---------------------------------------C-------- Npr3_Spur ---WNLPVVTGV---------------------------------------S-------- Npr4_Spur TVTANQHFFDWG---------------------------------------V-------- Gcy1_Spur ---LNIPMIDYV---------------------------------------C-------- Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque ---LKA----------------------------------------FLGVQL-------- AqueK221_Aque ---VKQPVVHASLSHLIEYLRPLLSVKHHWTIDACPGNEHAWYVELLIGRES-------- AqueK222_Aque ---FYESLFGFH---------------------------------------L-------- HSER_Hsap -----------------FG-LS-----CDY-KETL------------------------- CG10738_Dmel -----------------TH-RDP-S--NKADFPTF------------------------- CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel -----------------SD-PIV-S--NKSTFHTF------------------------- Gyc76C_Dmel -----------------AE-YR------ASAIPTF------------------------- CG4224_Dmel -----------------NA-KEFNK--KSESYSTL------------------------- CG3216_Dmel ELTVTSGILGRIHKWKNENTGMF-K--DKSKYPTL------------------------- KSGC_Mmus -----------------QM-AAL-K--DHFWCDTC------------------------- HSER_Mmus -----------------YG-LS-----CDY-KETL------------------------- CYGX_Mmus -----------------EA-PEG-G----------------------------------- CYGF_Mmus -----------------VN-HEL-D--NKHSFPTF------------------------- CYGD_Mmus -----------------PG-TRA-A----------------------------------- ANPb_Mmus -----------------VA-SGFAA--KNEHYRTL------------------------- ANPa_Mmus -----------------PA-LGI-G--VKDEYALT------------------------- odr-1_Cele -----------------V-FEAR-G--VQ-ELTSV------------------------- gcy-9_Cele -----------------G-DDAL-S--DRVQFPTL------------------------- gcy-8_Cele -----------------A-SNNL-A--DKNAYPTL------------------------- gcy-7_Cele -----------------VNAAQL-D--DFERFPNA------------------------- gcy-6_Cele -----------------TSSATL-D--DESRFPTA------------------------- gcy-5_Cele -----------------VSDTQL-A--DTNRFPYV------------------------- gcy-4_Cele -----------------VSESEI-S--DMNRFPFV------------------------- gcy-3_Cele -----------------VSQADL-S--DMTRFPYL------------------------- gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele --------------------APL-S--TKEKESTT------------------------- gcy-23_Cele -----------------S-SNSF-A--DKTIFKTL------------------------- gcy-22_Cele -----------------PFDSSL-L--NQFEYPTI------------------------- gcy-21_Cele ------------------E-MDLSS--VKGFDQTS------------------------- gcy-20_Cele -----------------TTTADI-G--NFSRYQTT------------------------- gcy-2_Cele -----------------VSDTDL-S--DVIRFPYL------------------------- gcy-19_Cele -----------------VTDSKF-T--DTERYPYL------------------------- gcy-18_Cele -----------------V-PNAV-S--DRSVYKTL------------------------- gcy-17_Cele -----------------TSTRQL-T--DVKRFPTT------------------------- gcy-15_Cele ------------------E-MDLSS--VKGFDQTS------------------------- gcy-14_Cele -----------------TTAADI-G--NVSRYPTT------------------------- gcy-13_Cele -----------------TISSSF-I--DTSKYPTT------------------------- gcy-12_Cele -----------------ND-QDISR--DDYHYRTF------------------------- gcy-11_Cele -----------------ED--QVGE--SQMPSSTA------------------------- gcy-1_Cele -----------------VSDTDL-S--DVIRFPHL------------------------- daf-11_Cele ---------------------LK-G--YPYEHPTM------------------------- C04H5.4_Cele -----------------T-SAEF-A--NTKVYKTL------------------------- CYGF_Hsap -----------------VN-YEL-D--NKISYPTF------------------------- ANPb_Hsap -----------------VA-SGFSA--KNDHYRTL------------------------- ANPa_Hsap -----------------PA-LGF-G--VKDEYALT------------------------- CYGD_Hsap -----------------PW-TQA-E----------------------------------- T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur -----------------SS-RDL-E--NEAIYSTL------------------------- Gcy3_Spur -----------------AE-SKL-S--DKSIYPTF------------------------- Npr3_Spur -----------------TS-AVL-D--DKSRYRTL------------------------- Npr4_Spur -----------------RNDTKY-AMENGRVFSKFKTGTEAMNWCHNTKCPAPNEANMEN Gcy1_Spur -----------------DE-NPV-S--DKSIYPTF------------------------- Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque -----------------KYDSSC-T--SEVR-DTQ------------------------- AqueK221_Aque -----------------KEPVLC-Y--D-NV-NVN------------------------- AqueK222_Aque -----------------SS-YNI-N--SSNDLRTF------------------------- HSER_Hsap -----------------------TRLM--------------------------S---PAR CG10738_Dmel -----------------------ARTR--------------------------P---PDT CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel -----------------------ARTL--------------------------A---PAS Gyc76C_Dmel -----------------------ARTE--------------------------P---PDT CG4224_Dmel -----------------------TRLK--------------------------G--AQVN CG3216_Dmel -----------------------TRMS--------------------------Y---CQC KSGC_Mmus -----------------------VTLV--------------------------P---PKQ HSER_Mmus -----------------------TRIL--------------------------P---PAR CYGX_Mmus -----------------------GDLV--------------------------P---TLP CYGF_Mmus -----------------------SRTL--------------------------P---SP- CYGD_Mmus -----------------------GTTA--------------------------P---AVT ANPb_Mmus -----------------------VRTG--------------------------P---SAP ANPa_Mmus -----------------------TRTG--------------------------P---SHV odr-1_Cele -----------------------INVA--------------------------Q--FSVG gcy-9_Cele -----------------------GSVA--------------------------L--TSAS gcy-8_Cele -----------------------ARISAFIISKIHKYYFFFNFLDDRSKVGISL--RTTN gcy-7_Cele -----------------------GILS--------------------------A---GQR gcy-6_Cele -----------------------GMLS--------------------------I---GSR gcy-5_Cele -----------------------ASVQ--------------------------P---TAQ gcy-4_Cele -----------------------ASVL--------------------------P---STK gcy-3_Cele -----------------------ITVL--------------------------P---TSQ gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele -----------------------IALK--------------------------P--HSLA gcy-23_Cele -----------------------ARVS--------------------------L--RTTN gcy-22_Cele -----------------------ASTT--------------------------S---STL gcy-21_Cele -----------------------VLMN-----------------------------SQTN gcy-20_Cele -----------------------VTLS--------------------------L---DTH gcy-2_Cele -----------------------TTVI--------------------------P---NSL gcy-19_Cele -----------------------TNIM--------------------------A---NSL gcy-18_Cele -----------------------ARVS--------------------------S--KNTN gcy-17_Cele -----------------------LPFS--------------------------V---NSY gcy-15_Cele -----------------------VLMN-----------------------------SQTN gcy-14_Cele -----------------------VTLS--------------------------L---DTH gcy-13_Cele -----------------------VTIV--------------------------P---VAK gcy-12_Cele -----------------------ARTV-----------------------------PPAG gcy-11_Cele -----------------------LQMS-----------------------------STQG gcy-1_Cele -----------------------TTVI--------------------------P---NSL daf-11_Cele -----------------------IDMV--------------------------T--RSPQ C04H5.4_Cele -----------------------LRTS--------------------------F--QSLN CYGF_Hsap -----------------------SRTL--------------------------P---SP- ANPb_Hsap -----------------------VRTG--------------------------P---SAP ANPa_Hsap -----------------------TRAG--------------------------P---SYA CYGD_Hsap -----------------------GTTA--------------------------P---AVT T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur -----------------------TRTT--------------------------Q--IIAS Gcy3_Spur -----------------------ARTI--------------------------P---TDD Npr3_Spur -----------------------TRTS--------------------------F---KTG Npr4_Spur CCLHHVNVHSCPQEHLADSGGICGPWV--------------------------PPSGDIF Gcy1_Spur -----------------------LRTI--------------------------P---PSI Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque -----------------------LSMA--------------------------A---PHL AqueK221_Aque -----------------------LGLS--------------------------T---TLY AqueK222_Aque -----------------------CHSS--------------------------P---CPT HSER_Hsap KLMYFLVNFWKTNDLPFKTYSWSTSYVYKNGTE-TE----DCFWYLNALEAS------VS CG10738_Dmel QISKSVV-------ALLLAFNWTQVSFLYLDDASGQYQP-----VAETILSTLTD----- CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel KVSKSVI-------SLLNAFHWNKFSIVVSSKPIW-GSD-----VARAIQELAEA----- Gyc76C_Dmel QVVKSLL-------ALLRYYAWNKFSILYEDV--W--SP-----VADLLKDQATK----- CG4224_Dmel NLGNVVR-------AILNSFNWTRTALIYQNENAKVKGNSVCFLCLAAIHDTIEE----- CG3216_Dmel RLILVFA-------SVIRQFNWNHVALLVDRSELF--SW----TVGKNLEYGLRQ----- KSGC_Mmus EISAVLR-------ESLRYLGWEHIGVFGGSSA--D----SSWEQVDEMWGAVED--GLQ HSER_Mmus KLMYFLVDFWKVNNASFKPFSWNSSYVYKNGSE-PE----DCFWYLNALEAG------VS CYGX_Mmus SAADVLL-------SVMRHFGWARWAIVSSHQDIW--VT-----TAQQLATAFRT----- CYGF_Mmus --IRVLV-------TVMKYFQWAHAGVISSDEDIW--MH-----TANRVSSALRS----- CYGD_Mmus PAADALY-------VLLRAFRWARVALITAPQDLW--VE-----AGRALSTALRA----- ANPb_Mmus KLGEFVV-------TLHGHFNWTARAALLYLDARTDD--RPHYFTIEGVFEALQ------ ANPa_Mmus KLGDFVT-------ALHRRLGWEHQALVLYADRLGDD--RPCFFIVEGLYMRVRE----- odr-1_Cele GVAETLV-------FLMKELEQVEITLVGSVKVLP-N--------GLSLSNDLRS--Y-N gcy-9_Cele EMAKATV-------TYLNLNNWDQIGIVRPSVGYE-R------LSVYSLQHQIKK--R-D gcy-8_Cele SIAEATC-------AMLRHYGWNKVAIITNTGILA-Y------DRVLSFEEVFHQ--R-G gcy-7_Cele SLGVAIR-------AVLKRYEWSQFVYAYFTEEDTEK----CVTMRNDLQQVVSY--F-G gcy-6_Cele SLAVTFR-------EVMKEYGWDQFVFAYSLEMNDEK----CETLRDDFQNMVAY--Y-G gcy-5_Cele TLGLATS-------RILEMFQFDRVALLYYKDDQ-DY----CKSVMDDVEATLSD--P-D gcy-4_Cele TLGVVTS-------KLLEIYGWDRVALLYFKNEL-DY----CSSVVNDVEKSLYN--E-S gcy-3_Cele TLGYAAS-------KLLELYKWDKVALLYYKSEV-NH----CGGVMNDVETTFND--P-S gcy-27_Cele -----------------SVYNWCYETVIGEN----------------------------- gcy-25_Cele GTAEVIL-------AMCKSMKWKEIGIIYSEETK--YTA----HAIYDM---LAE--Q-- gcy-23_Cele SLAEAAA-------ALIKHYGWNKVAIATNTGAVA-F------ERVQSFEEVFHQ--R-G gcy-22_Cele YQATSLI-------RLLEYYKWTEIALIYYVARSD------------------------- gcy-21_Cele SLAKSVM-------YFLDKYQWKKVALVSPSTVLTAFAT----RVRSDLLD------ALT gcy-20_Cele SISLAVR-------EILRQYGWSEFVFIYSNDGDEEK----CAAMKDDMEKMGIE--N-S gcy-2_Cele MLGYAAS-------KMLTVYNWGRVAMLYYYSDI-KY----CSGVMNDVEATFNN--P-S gcy-19_Cele SLGFSLV-------KLLEMMEWDRVALVYEESAQ-DY----PLSVINDVETAINE--Y-D gcy-18_Cele SIAEATV-------ALLLHYKWLKVAIATNTGSTA-F------ERVSIFEEIMHR--E-G gcy-17_Cele SLAMAIL-------GTLKQFQWTEFVFLYCNDGDDEK----CESLKDDVQ---------- gcy-15_Cele SLAKSVM-------YFLDKYQWKKVALVSPSAVLTAFAA----RVRSDLLD------ALT gcy-14_Cele SMALGVR-------EVLRRFEWDEFVFIYSNDGDEEK----CASMKDDLEKMGIE--N-S gcy-13_Cele SIAAAIH-------EVMIQFEWTEFVYVFVEDE---K----CGYFRDDLEQITSD--S-N gcy-12_Cele EIFKAFM-------SLMKQYNWRKFSVVYDVKKGQV-KN----ELFETLKRMVETENKFE gcy-11_Cele GKYRAFA-------KLAKSVGWNNLAVINFVEDGPA-DI----SYHDQLLD------ALS gcy-1_Cele MLGYAAS-------KMLTTFHWNRVALLYYFSDV-KY----CSGVMNDIEATFND--P-S daf-11_Cele NLAQNLV-------SLLRGFEWGQVGAVLCEECYE-GDELASEIYFSTIEDIFEN--N-N C04H5.4_Cele SISEATA-------AFMAHHNITKAAIVANIGTDS-F------EKIQSLEKALRS--R-G CYGF_Hsap --IRVLV-------TVMKYFQWAHAGVISSDEDIW--VH-----TANRVASALRS----- ANPb_Hsap KLGEFVV-------TLHGHFNWTARAALLYLDARTDD--RPHYFTIEGVFEALQ------ ANPa_Hsap KLGDFVA-------ALHRRLGWERQALMLYAYRPGDE--EHCFFLVEGLFMRVRD----- CYGD_Hsap PAADALY-------ALLRAFGWARVALVTAPQDLW--VE-----AGRSLSTALRA----- T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur GYAYAIV-------EVLRHFGWGVASVIWDGGI-NY-WS-----LIEEAATR--E----- Gcy3_Spur LLTEAVS-------VLLEYFNWYNVSIVSSSESN--RLS-----VSESLQLKLPT----- Npr3_Spur VLAKAVV-------AFFEEYEWRQFALVWQYPGYSSLIA----IAMKELMET--Q----- Npr4_Spur THTESNV-------DSLNHTDWTTPLALVPDGVTS------------------------- Gcy1_Spur QVVEAMI-------LTLQRYDWDQVSVVVENIT--KYRN-----IFNTMKDKFDE----- Gcy2_Spur -------------------------TITY------------------------------- Npr5_Spur ------------------------------------------------------------ AqueK220_Aque SLYSAGY-------SFVQRMGWKKFGLITTCDCFLRF-----FTTSDEVQ---LG--H-Y AqueK221_Aque NLYKATY-------MFVKKFNWKRIGILTTCTECVEA-----WPGNEYAV---IS--Y-Y AqueK222_Aque QMA------------SLRSFKE-------------------------------------- HSER_Hsap Y-FSHELGFK---V-------------V------LRQ--DK-EFQDI--LMDHNR--KSN CG10738_Dmel --AGVSIRDI--RTWNT-----IY-H-H------GFM--DN-PFEAL--VEQTYA--NTR CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel --RNFTISHF--KYIS-DYI------PT------TKT--LS-QIDKI--IEETYA--TTR Gyc76C_Dmel --RNMTINHK--QSFIDNRVKCCEQMLD------CCR--SG-YWYQL--VQNTMN--RTR CG4224_Dmel -HSVYQLGFD---TS-------------------TWT--KA-DITRM--LKNVAM--QSR CG3216_Dmel -EGLLSFV-K---EL------------N------GNE--EE-VYENY--LKDASM--YAR KSGC_Mmus FHFNITASMR---Y-------------N------SSS--SD-LLQEG--LRNMSY--VAR HSER_Mmus Y-FSEVLNFK---D-------------V------LRR--SE-QFQEI--LTGHNR--KSN CYGX_Mmus --HGLPIGLV--TSL------------G------PGE---K-GATEV--CKQLHSVHGLK CYGF_Mmus --QGLPVGVV--LTS-------------------GRD--SQ-SIQKA--LQQIRQADRIR CYGD_Mmus --RGLPVALV--TSM------------E------TSD--RS-GAREA--LGRIRDGPRVR ANPb_Mmus -GSNLSVQHQ---VY------------A-------RE--PG-GPEQA--THFIRA--NGR ANPa_Mmus -RLNITVNHQ---EF------------V------EGD--PD-HYTKL--LRTVQR--KGR odr-1_Cele -EIMNSFKIR--EYVE-----------V------DEN--DV-DWTKV--DQKIKR--GAR gcy-9_Cele --I--NLNVI--LDIEP----------F------SSP--EEIISTGK--LTTLKS--MAR gcy-8_Cele --I--NVVKK--IMFDE----------F------ADS--KAMIASGL--LNDIKN--SAR gcy-7_Cele -D--IILAYS--IQV------------A------DIS--ND-GMIEA--LKKIQS--RGR gcy-6_Cele -D--IVLSYA--VQI------------M------DHS--EE-GLLAI--LKDVST--RGR gcy-5_Cele -LYPVRIVWK--GEL------------Q------SDN--EA-LTRST--LQAVKS--RAR gcy-4_Cele --KSVQIVMK--AEI------------D------GSN--SE-STSAT--LQVVKT--RAR gcy-3_Cele -TYSIQIVLK--AEI------------D------ASD--NV-TTNAV--ISSVKT--RAR gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele -EDDLKINVF--LET------------D------G----LS-NTYT------ILHSA--R gcy-23_Cele --I--NVVRK--IMLEE----------Y------TNA--KAIMNSGL--LQELEN--SAR gcy-22_Cele ------------------------------------------------------L--IPR gcy-21_Cele -ANKIDILVD--SR-------------L-------DP--MS-DITDK--VKEDAE--KAR gcy-20_Cele -D--VTMAYM--IQI------------Q------TVT--ME-SLQRT--LLEVSK--RGR gcy-2_Cele -TPNVNIVIK--AEI------------Y------LND--NE-TTDIV--FQSVKS--RAR gcy-19_Cele -TFAVNVVVK--QAL------------P------GGDLNDA-QYISV--LNRIKL--RCR gcy-18_Cele --V--TIVKK--VMFDE----------N------TDA--NEMMNSGQ--LGDLAA--NAR gcy-17_Cele -----------------------------------------------------------V gcy-15_Cele -ANKIDILVD--SR-------------L-------DP--MS-DITEK--VKEDAE--KAR gcy-14_Cele -D--VTLAYM--VQI------------Q------TVT--LD-ALQKA--LTEVSK--RGR gcy-13_Cele -Y--TSLSRT--IQI------------Y------DQS--YT-NLVRQ--LEKLKT--VSR gcy-12_Cele -EHKFEIMNVSKLEFSK----------MDISS--QQD--IQ-SIENA--IKSTMQ--TTR gcy-11_Cele -AESISLDFVKKGGFSS-----------TITSAMFTG--LE-SVIDV--ILETYM--KTR gcy-1_Cele -TPNVNIVIK--AEI------------Y------LND--NE-TTDNV--FQTVKS--RAR daf-11_Cele --I--ALKET--VRIGK------------------RE--NSVNISDA--ITIFEP--SAR C04H5.4_Cele --I--TVARR--VMFEE----------A------ASA--QDLVDNGY--MNELRD--NAR CYGF_Hsap --HGLPVGVV--LTT-------------------GQD--SQ-SMRKA--LQRIHQADRIR ANPb_Hsap -GSNLSVQHQ---VY------------A-------RE--PG-GPEQA--THFIRA--NGR ANPa_Hsap -RLNITVDHL---EF------------A------EDD--LS-HYTRL--LRTMPR--KGR CYGD_Hsap --RGLPVASV--TSM------------E------PLD--LS-GAREA--LRKVRDGPRVT T01A4.1_Cele -------I-N---EV--------------------------------------------- Npr1_Spur ------------------------------------------------------------ Npr2_Spur -LDRIEFDYH---DF------------S------MRA--IS-DNFLA--LLNASK--VGR Gcy3_Spur --KNIHISDV--KIYASPYIPPLY-EPE------NGV--EP-EMRAI--VRETYE--HTR Npr3_Spur --ENVTM--Y---EF------------D------LRD--YG-SIKDA--LDAAAA--VSR Npr4_Spur ------------------------------------------------------------ Gcy1_Spur --RDYEILHE--EYYA-GFD-----PWD------YEM--DD-PFSEI--IQRTKE--TTR Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque ----VP---------------------------------MR-FIEMFKMSGFEEH--EIN AqueK221_Aque ----DP---------------------------------SD-FISSF--TPFKGR--EIH AqueK222_Aque ---NCCVWHA--N----------------------------------------------- HSER_Hsap VIIMCGGP-----EFLYK---LKGDRA--VAEDIVIILVDL--FN-DQ-Y---------- CG10738_Dmel IYLILGHY-----YEHVGLMVSLQRRGILSKGDYFVVGIDI--EQ-YD-PAK----PE-K CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel IYVFIGEH-----IAMVDFVRGLQNRRLLESGDYIVVSVDD--EI-YD-SNR---RVN-I Gyc76C_Dmel IYVFLGAA-----NSLVDFMSSMETAGLFARGEYMVIFVDM--MV-YS-ERE----AE-K CG4224_Dmel IVIMCADP-----QSIRQIMLTAEELNMIDSGEYVFINIEL--FS-RV-QYL-------- CG3216_Dmel VVILSVRG-----VLVRKFMLAAHSLG-MTNGEWVFLDVEI--FQ-SE-Y-W----G--- KSGC_Mmus VIILICSS-----EDARRILQAAVDLG-LDTGEFVFILLQQ--LE-VG-F---------- HSER_Mmus VIVMCGTP-----ESFYD---VKGDLQ--VAEDTVVILVDL--FS-NH-Y---------- CYGX_Mmus IVVLCMHSALLGGLEQTTLLHCAWEEG-LTDGRLVFLPYDT--LL-FA-LPY----G--- CYGF_Mmus IIIMCMHSALIGGETQTHFLELAHDLK-MTDGTYVFVPYDV--LL-YS-LPY----K--- CYGD_Mmus VVIMVMHSVLLGGEEQRYLLEAAEELA-LTDGSLVFLPFDT--LH-YA-LSP----G--- ANPb_Mmus IVYICGPL-----EMLHEILLQAQREN-LTNGDYVFFYLDV--FG-ES-LRA----GP-T ANPa_Mmus VIYICSSP-----DAFRNLMLLALDAG-LTGEDYVFFHLDV--FG-QS-LQG----AQ-G odr-1_Cele MIVVCADF----YDIYSAF-YNIGIRS-LSGFRFIIVVI-L--NK-P--PD--------- gcy-9_Cele IIVVELGMD---IHSVTNFMLAIHRSE-IKNEEFVFVIPWL--AH-Q--ND--------- gcy-8_Cele IVVCLFSNT---RESSREFLTAANTQG-MNVNEYGYVFPWL--QD-GG-KD--------- gcy-7_Cele IIVTCMKDG---IGLRRKWLLAAEEAG-MIGDEYVYVFSDI--KS-KG-YVV----PL-L gcy-6_Cele IIVPCFHEGN-SRGLHRRWMLVAARNG-FVNDEYVYIFPSL--RS-RG-YAV----PQ-A gcy-5_Cele IVLLCAISG----PEKRNYLISIAQQN-MTTNEYVHILLTM--RS-IG-YGV----QT-S gcy-4_Cele VILFCAHAG----GEKRFYLIQAGLLG-MNSSEYVHVMLSM--RS-VG-FGV----QT-S gcy-3_Cele IILWCAQLG----SEKRDYMIKISQLG-LDTDEYVHVLISM--RS-IG-FGV----QT-F gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ALISFLT-T---LDLS-KFFKTLKENA-FRPLEFSIVHVDC--NK-SE-ISN-------- gcy-23_Cele VVVCAFSST---RDMNKEFMQAVTLSG-MNNANYAWILPWL--QL-ET-KD--------- gcy-22_Cele FVIVCLESD----EARRNLMISISENG-MDGDEYVYIMAES--RR-AG-FAS-------- gcy-21_Cele IFIICDWSS--NANLLRNYLFKLGEMNKMQSGEYFVLGYIS--YD-TN------------ gcy-20_Cele IIIACFASG---RGFKKAFIASTVLAG-MSTEEYLYVFAEP--QS-RG-FYV----DE-A gcy-2_Cele IIFWCTQTA----IEKRDYLIKIATHD-MIGDEYVHIMLSM--RN-IA-FGA----QT-S gcy-19_Cele IIVSVFQTA----PTRRRYLKMIDQQG-MANEEYVHILLGL--RS-IG-FGK----QS-A gcy-18_Cele IIICLFSST---KELSKEFMQATYTMR-MNNAEYAYIIPWL--QS-GT-KD--------- gcy-17_Cele IIVACVASG---NGSKRTLMQAVALEN-ANNSEYVYIMAET--NS-RG-FVV----EE-V gcy-15_Cele IFIICDWSS--NANLLRNYIFKLGEMNKMQSGEYFVLGYIS--YD-TN------------ gcy-14_Cele IIIACFANG---RGFKKAFVASTVLAG-MSTDEYMYMFAEP--QS-RG-FYV----DE-I gcy-13_Cele IFTVCLPEA---GDIKRRFMLAAYDLD-MTTDEYVYLFAGP--KS-TA-YQQ----TS-S gcy-12_Cele IYLTF---D--NVRLFRTMLSIMGEMGL-TQQDYMLIYVDT--N--YDWLNVYHSMNN-H gcy-11_Cele IYVIVL--D--LPVSGTFFMNAMSTMGLLETGKYFVVMMSS--IE-SDAANYFG------ gcy-1_Cele IILWCTQTS----VEKRDYLIKIATHD-MIGDEYVHIMLSM--RN-VA-FGT----QT-S daf-11_Cele VILLFLGNK---LNDYTEFMTAMSMNN-YTTEEYTPVIVIS--KN-SL-EL--------- C04H5.4_Cele VILPIFSST---RDLSTVFRNATWLAN-MASPEFIYINPLI--VA-RN-SE--------- CYGF_Hsap IIIMCMHSALIGGETQMHLLECAHDLK-MTDGTYVFVPYDA--LL-YS-LPY----K--- ANPb_Hsap IVYICGPL-----EMLHEILLQAQREN-LTNGDYVFFYLDV--FG-ES-LRA----GP-T ANPa_Hsap VIYICSSP-----DAFRTLMLLALEAG-LCGEDYVFFHLDI--FG-QS-LQG----GQ-G CYGD_Hsap AVIMVMHSVLLGGEEQRYLLEAAEELG-LTDGSLVFLPFDT--IH-YA-LSP----G--- T01A4.1_Cele ----------------------------------------Q--F--RL-P-L----N--- Npr1_Spur ------------------------------------------------------------ Npr2_Spur IIFMAVDG-----DTLREIMLHAYDLD-LINGDYAFINIIP--FR-DE-QLF----G--- Gcy3_Spur IYIFIGEL-----WEVYELLHEMMYHGLLENGEYMVIWANQ--EN-FD-YKQ----LH-L Npr3_Spur IIILSAQG-----ELVREAMLHAFDTG-LVDGEYAFVSIEP--FS-NT-LVF----G--- Npr4_Spur -IIAHIR----------------------------------------------------- Gcy1_Spur IYVFFGDA-----SDLRQFAMTALDEGILDSGDYVILGAVVDLEV-RD-SQD-YHSLDYI Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque IYIFLGPM-----VDFFRLLVEAYDNG-FSGSLRTFVWIVL--TFHPN-ITE-------- AqueK221_Aque IYIFLGNT-----KSYLDMLLEFNLR--RKSDFRLFTWILP--FNCPS-F---------- AqueK222_Aque IHVC--HP-----GN-----------------------------------CG----KP-S HSER_Hsap ----------------------------------F-ED------------N--VTAPDYM CG10738_Dmel YL-----------------------------RGLL-LE-----D-------VEPLAVQAF CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel ME---------RNY-----------------LDPY-IR---KEK-------SKSLDKISF Gyc76C_Dmel YL-------------RR---V---------DQITF-MS---NCH-------STENFNQMA CG4224_Dmel ------------------------------TSQPW-YD---KND---TD-LNNERAQKAY CG3216_Dmel -------------------------------DKGW-EM---KDE-------HDAKARKAY KSGC_Mmus ----------------------------------W-KE---VLT----K-DKVIRFPKVY HSER_Mmus ----------------------------------F-EE------------N--TTAPEYM CYGX_Mmus -------------------------------NRSY-LV----------L-DDHGPLQEAY CYGF_Mmus -------------------------------HSPY-QV----------L-RNNPKLREAY CYGD_Mmus -------------------------------PEAL-AA----------F-VNSSQLRRAH ANPb_Mmus ----------------R---A---------TGRPW-QD---NRT----Q-EQAQALREAF ANPa_Mmus ----------------P---V---------PRKPW-ER---DDG-------QDRRARQAF odr-1_Cele -------------------------------E-----I---LNQ------P-NVKNLLYG gcy-9_Cele -------------------------------HYPW-EA---ANV------D-KQEVKLAF gcy-8_Cele -------------------------------ASPW-TG---ADG------SMLQKVKDQY gcy-7_Cele GG--------------G---E----------RPSW-IL---STGS---D-ENDTRALKAF gcy-6_Cele DG--------------T---F----------RYPW-TE---ATGP---Q-PGDQEALLGF gcy-5_Cele LG--------------K---K-TF--A-NGLTPLW-ES---FTVA--PD-GNETNARRAA gcy-4_Cele VG--------------K---K-PL--TLSGLPPIW-ES---FTVN--PD-GMEDLAKSVA gcy-3_Cele VG--------------K---T-TF--KLSGLTPVW-ES---FSNV--TD-GLENVAKRGA gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele -------------------------------FYTY-LD---NNAGEEPNPISAARLRKLY gcy-23_Cele -------------------------------MAPW-LG---ENG------EYQQNVKDHF gcy-22_Cele --------------------------------SFW-NG---T------D-GKNDLALRAA gcy-21_Cele --------------------------------YQW-LE---ASS-------GDQRLK--- gcy-20_Cele DG--------------K---V----------HYSW-DD---TDGQ-LVTGLTNEQIRDAY gcy-2_Cele LG--------------K---P-TF--SQSGLTPIW-ES---FTEG--TD-DFEKMVKQAA gcy-19_Cele GL--------------T---KCELNCLSSGLAPFW-DI---A--P--DD-GLNDRLKQAA gcy-18_Cele -------------------------------LTPW-IG---ADG------EMLQRVKDHY gcy-17_Cele GG--------------K---W----------HYLW-EG---KFDD--SDTFSTEDSRTSM gcy-15_Cele --------------------------------YQW-LE---ASS-------GDQRLK--- gcy-14_Cele NG--------------G---E----------HYSW-DD---TDGN-FVTGLTPEQIRDAY gcy-13_Cele TG--------------D---V----------VGIW-VD---WSEN--PD-GRDEEAKLAF gcy-12_Cele FLR-------------NTMTY---------LHHSW-DA---NNS-------SDRKMLDYA gcy-11_Cele F-----------------------------------NV---N------------------ gcy-1_Cele LG--------------K---P-TF--SQSGLTPIW-ES---FTEG--TD-GFEKMAKQAA daf-11_Cele -------------------------------TFPW-KE---ND-----------AIAELF C04H5.4_Cele -------------------------------EPPVFYG---KM--------AQKSIKAEN CYGF_Hsap -------------------------------HTPY-RV----------L-RNNPKLREAY ANPb_Hsap ----------------R---A---------TGRPW-QD---NRT----R-EQAQALREAF ANPa_Hsap ----------------P---A---------PRRPW-ER---GDG-------QDVSARQAF CYGD_Hsap -------------------------------PEAL-AA----------L-ANSSQLRRAH T01A4.1_Cele -------------------------------DRR-------------------------- Npr1_Spur ------------------------------------------------------------ Npr2_Spur -------------------------------DDSW-ER---GDN-------RDEEAKVAY Gcy3_Spur FQ-----------------------------GDPY-LR-----Q-------PSREVMMYY Npr3_Spur -------------------------------DDNW-KQ---NDG-------RDDDAKKAY Npr4_Spur ----------------------------------------------------IGNWQAAL Gcy1_Spur LDTSEYLNQINPDYARL---F---------KNREY-TR-----S-------DNDRALEAL Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque -------------------------------SEVF-KQ---HSF----S--PEDK-AKVY AqueK221_Aque -------------------------------SKVF-DKISRKYF----N--SHQI-QRIE AqueK222_Aque QI-----------------------------CGPW-VD---NDQ-------VQSTH---- HSER_Hsap KNVLV-LTL--SP-G-N-SLLNSSF-SR--------------------NL---------- CG10738_Dmel QSYLG-IV----P-T-A-SVSFATF-ANEVNKYMERPP---FN----FPN----P----L CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel RSVIK-ISM--TY-P--------------------------------------------- Gyc76C_Dmel RSLLV-VAS--TP---P-TKDYIQF-TKQVQKYSSKPP---FN----LEI----P----R CG4224_Dmel TAMLT-VTP--KQ-P-N-DNEYTRV-SNEIKAI-AAEK---YN----YTF----S----- CG3216_Dmel EALLR-VSL--LQ-P-T-SPKFQDF-ADNVREN-ALYD---YN----YTF----G----- KSGC_Mmus ESVFL-IAP--SA-Y-GGGIGDDGF-RKQVSQELRRPP---FQ----SSI----T----- HSER_Mmus DNVLV-LTL--PS-E-Q-STSNTSV-AE--------------------RF---------- CYGX_Mmus DAVLT-VSL--ES-S-PESH---AF-TATE-MS-GGAT---AN----------------- CYGF_Mmus DAVLT-ITV--ES-H-EK-TFYEAY-AEAA-AR-GEIP---EK----------------- CYGD_Mmus DAVLT-LTR--RC-P-PGGSVQDSL-RRAQ-EH-QELP---LD----------------- ANPb_Mmus QTVLV-ITY--RE-P-P-NPEYQEF-QNRLLIR-ARED---FG----VEL----A----- ANPa_Mmus QAAKI-ITY--KE-P-D-NPEYLEF-LKQLKLL-ADKK---FN----FTM----E----- odr-1_Cele SNAFIISP------L-Q-EQYSDAF-SI-MQDV----I---------P------------ gcy-9_Cele ENTIIITA---HG-Y-D-KKFFDDF-QMKFSAV----T---------G------------ gcy-8_Cele ANAIIIDDV--NS-F-D-NTIVGPF-IERIKDV----G---------L------------ gcy-7_Cele KQSIFICDM--MGQG-SIATNYTIF-GQEIIARMKEAP---YF----CT-----K----D gcy-6_Cele QKSIFIVDM--QGQG-NVGSNYTQF-EHEIIQRMKEPP---YN----CT-----D----A gcy-5_Cele EKML-VIDV--NSDV--QDAEFLQYLTKNIADAVRNPP---MK----CNT----S----E gcy-4_Cele AKMI-VIDT--SSEV--RDKTFLQYMTKNIVYAIREPP---LS----CKV----P----E gcy-3_Cele TNVL-VIDL--NSEV--SDKAYLDYMQRNILNVVKLPP---LN----CST----V----D gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele RHVAL-LKN--SHD--D-MEKTEEF-AKKYGLV-ARCS---LC----FVA----CFHFFS gcy-23_Cele ANSFIIDDV--NG-F-D-NTLVTPF-KERLEAS----G---------Y------------ gcy-22_Cele RKFL-VMDN--QKYN-----DTTTF-VQEVRAAFSRPP---FS----CP----------N gcy-21_Cele ------I--TP---------RWD------------------------------------- gcy-20_Cele GKVLYICDN--MGEPTTITTQYTNF-TSQVISRMAEQP---FN----CV-----Q----D gcy-2_Cele TRMF-VLDV--NSEV--ADKKYLDYLQKNIMKAVQSPP---MN----CST----V----E gcy-19_Cele TRML-VMDL--STDV--PDINYLNTFTMNCGAVVVNPP---VS----CAT----P----A gcy-18_Cele ANAIIVDDV--NG-F-D-DSVVSSF-VEKIEKH----G---------M------------ gcy-17_Cele ANLLFLVDN--MGMNNVVTPQYLNF-SKNVIEMMKDEP---FN----CV-----E----D gcy-15_Cele ------I--TP---------RWD------------------------------------- gcy-14_Cele GKVLYICDN--MGLPTTITPEFANF-SSQLISRMTEQP---FN----CV-----Q----D gcy-13_Cele MRTMVIVAT--P----VQGEQYAAF-KKEVIERMKLPP---YN----CV-----D----E gcy-12_Cele RSALS-IIPTPVK-L-N-SQRFYNF-WKKAGDYM--HH---FG----VQK----A----- gcy-11_Cele -----------RD---F-SDEWTSF-QKRVDGDA-SKT---FCPPMCNTK----A----- gcy-1_Cele TRMF-VLDV--NSEV--ADKKYLEYMQKNIIKAVQSPP---MN----CST----V----E daf-11_Cele DKAIIVYN---NC-Y-D-KSKISSF-LSSYSF---------------S------------ C04H5.4_Cele PNTIQIYNS--YG-F-S-DDLLNEF-LAIFDQN--------------------------- CYGF_Hsap DAVLT-ITV--ES-Q-EK-TFYQAF-TEAA-AR-GEIP---EK----------------- ANPb_Hsap QTVLV-ITY--RE-P-P-NPEYQEF-QNRLLIR-ARED---FG----VEL----G----- ANPa_Hsap QAAKI-ITY--KD-P-D-NPEYLEF-LKQLKHL-AYEQ---FN----FTM----E----- CYGD_Hsap DAVLT-LTR--HC-P-SEGSVLDSL-RRAQ-ER-RELP---SD----------------- T01A4.1_Cele --------V--SS-P-S-SEAT----RKK------------------------------- Npr1_Spur ------------------------------------------------------------ Npr2_Spur QALMT-IRV--FE-P-T-SEAYREF-EENVRER-QKRD---FN----ITD----S----- Gcy3_Spur RTLLA-LFL--SP-A-T-DPSYDNF-QRKTYKKLQEPP---FN----FDF----G----D Npr3_Spur ESLLI-FRL--FK-P-Q-TDEYRAF-QRELERR-EILD---YN----WTR----P----- Npr4_Spur HHIVT-VRP--RSEC--GNKNCEEL-EGE-------TC---SN----CPA---------D Gcy1_Spur KSVII-VTG--AP-V-LKTRNWDRF-STFVIDNALDAP---FN----GEL----E----L Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque H---------------------------MLVGAIAIQP---FD----N------------ AqueK221_Aque F---------------------------ELRGSFVIHPVQRFK----QDKNGRVI----- AqueK222_Aque ------------------------------------------------------------ HSER_Hsap -------SPT-KR--D---FA------LAYLNGIL-LF-G-HM-LKIFL---EN-GEN-- CG10738_Dmel G-PFGG-VKQ-IS--A---EA------AYLYDAVH-LY-A-KA-LMEVL---DS-GGRP- CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel ---QNP-HIR-VP--I---YG------LHLYDSVM-IY-V-RA-ITEVL---RL-GGDI- Gyc76C_Dmel LFVESN-FSKFIS--I---YA------AYLYDSVK-LY-A-WA-VDKML---RE-ETRV- CG4224_Dmel -----D-NEP-IS--A---FV------TSFFDGVL-LY-A-NA-LNESI---RE-DPTM- CG3216_Dmel -----E-GEE-VN--F---FI------GAFYDGVY-LL-G-MA-LNETL---TE-GGDI- KSGC_Mmus -----S-EDQ-VS--P---YS------AYLHDALL-LY-A-QT-VEEMR---KA-EKDF- HSER_Mmus -------SSG-RS--D---FS------LAYLEGTL-LF-G-HM-LQTFL---EN-GEN-- CYGX_Mmus ----LE-PEQ-VS--P---LF------GTIYDAVI-LL-A-HA-LNRSE---TH-GAGL- CYGF_Mmus ----PD-SNQ-VS--P---LF------GTIYNSIY-FI-A-QA-MNNAM---KK-NGRA- CYGD_Mmus ----LN-LKQ-VS--P---LF------GTIYDAVF-LL-A-GG-VKRAR---TAVGGGW- ANPb_Mmus -----P--SL-MN--L---IA------GCFYDGIL-LY-A-QV-LNETI---QE-GGTR- ANPa_Mmus -----D--GL-KN--I---IP------ASFHDGLL-LY-V-QA-VTETL---AQ-GGTV- odr-1_Cele --NLAD--DQ-FT------TF------LRIYHACY-AY-C-VGSVNGAE---TQ-TDNY- gcy-9_Cele --VLAN--HY-AT--L---SY------MSLYDALF-LY-G-LA-LRDAF---ED-GGGY- gcy-8_Cele --TEAD-VDI-AN--IY--GY------LYLFDALK-LY-A-IA-ARKVL---NE-TGKA- gcy-7_Cele C-EGEN-FTV-AA--T---YA------GQLHDAVY-AY-G-VA-LDKML---KA-GQI-- gcy-6_Cele C-ASPE-YQT-AA--T---YA------GQLHDSVY-IY-G-VV-MDQIM---KT-VPN-- gcy-5_Cele C-INAS-STS-MG--S---YA------RHLFDVFY-LY-G-MA-VSKLN---ST-DPT-- gcy-4_Cele C-LITN-ATG-MG--A---YA------RHLFDVFY-MY-G-MA-VSSLN---ST-DPN-- gcy-3_Cele C-VSST-ATG-MG--A---YA------RHLFDVVY-LY-G-IA-LTRVN---ST-DSA-- gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele Y-SFVSVFAY-LT--P---YLTTFQPSYTLYKALI-LCDGLQL-LNNYT---AP-RGNL- gcy-23_Cele --STDD-LEM-KN--IY--GY------IHLYDALR-LY-A-LA-VRATM---NE-TGNE- gcy-22_Cele C-TN---IDP-TV--S---QV------GPLGDALL-LY-A-YA-LNRSI---AT-GNP-- gcy-21_Cele -------------------RI------KLLFDSIQ-YL-A-DA-TNDAL---NI-GAN-- gcy-20_Cele C-SNQS-YKH-AA--T---YA------GQLADSFY-AY-A-FA-LNKSL---TQ-DPTR- gcy-2_Cele C-MTAN-TTI-MG--G---YA------RQLFDVVY-LY-G-VA-LTNTN---ST-DPA-- gcy-19_Cele C-INAS-TSP-PS--A---FA------RSLHDVFY-LY-G-LA-ITNLY---NQ-DPA-- gcy-18_Cele --QKSD-ID--TN--IN--GY------LHLFDSLK-LY-A-LA-IRKVL---NE-TDNE- gcy-17_Cele C-VGEE-YSS-VA--K---YA------GQLADAFY-AY-A-VA-VNRLL---TA-NPQ-- gcy-15_Cele -------------------RI------KLLFDSIQ-YL-A-DA-TNDAL---NI-GAN-- gcy-14_Cele C-SNST-YKV-PA--T---YA------GQLFDAFY-AY-G-VA-LNRSL---TQ-DPTR- gcy-13_Cele C-KEKE-YQE-AA--E---YA------DQLHDTIY-LY-A-LI-LNKTI---EE-QGI-- gcy-12_Cele -----D-NLK-GN--R---IA------CYLYDAVY-LY-A-KA-IHELV---EE-YGND- gcy-11_Cele K-GIANNDPW-SDDAYWYSES------PSIVDAY--DL-G-RL-LSETV---KV-HGAS- gcy-1_Cele C-MTAN-TTI-MG--G---YA------RHLFDVVY-LY-G-IA-LTHTN---ST-DPA-- daf-11_Cele --TIEE--TI-----I----S------LQMYEGYH-LL-G-YY-LYTAI---TN-TTL-- C04H5.4_Cele --QRIY-IDE-KD--LF--NY------VALYESFC-VF-A-KL-TEKYLHSLKE-KPEDG CYGF_Hsap ----LE-FDQ-VS--P---LF------GTIYNSIY-FI-A-QA-MNNAM---KE-NGQA- ANPb_Hsap -----P--SL-MN--L---IA------GCFYDGIL-LY-A-EV-LNETI---QE-GGTR- ANPa_Hsap -----D--GL-VN--T---IP------ASFHDGLL-LY-I-QA-VTETL---AH-GGTV- CYGD_Hsap ----LN-LQQ-VS--P---LF------GTIYDAVF-LL-A-RG-VAEAR---AAAGGRW- T01A4.1_Cele ----------------------------------------------NSN---EE-D--P- Npr1_Spur ------------------------------------------------------------ Npr2_Spur -----G-AGS-NI--F---LA------SAFYDVMI-LY-S-LA-INETI---AE-GGDV- Gcy3_Spur A---VD-VLG-IP--I---EA------AYLYDNVYNVY-A-PA-LNETL---AA-GYDI- Npr3_Spur -----D-PDH-NN--Y---FA------SAFHDAVI-LY-S-LA-VNETL---AE-GGNI- Npr4_Spur C-GRCP-LS--IG--A---LS------GIIAG-LY------------------------- Gcy1_Spur R-------AE-ID--F---AS------VYMFDATM-QL-L-EA-LDRTH---AA-GGDI- Gcy2_Spur -------------------------------DDL-SV----------------------- Npr5_Spur ------------------------------------------------------------ AqueK220_Aque -------CST-GL--I---RS------GVITDAIT-VH-S-LA-AMSCL---EE-KAAN- AqueK221_Aque --SMYE-GGK-GL--N---SA------GFIIDALQ-LD-I-FT-ADEFL---KT-KAAR- AqueK222_Aque ----------TIA--T---F-------GNINDTFT-A----------------------- HSER_Hsap -------------------ITTPKFAHA-FR--NLTFEGY--------------DGP-VT CG10738_Dmel R-------------------NGSAIVAA-IK--GSRYRSA--------------MGYHVY CG9783_Dmel -----------------------------------AAPGS--------------AGA-IT Gyc32E_Dmel Y-------------------DGNLVMSH-IF--NRSYHSI--------------QGFDVY Gyc76C_Dmel LT---------DDVIFEVASNGTRVIDTIIK--NRTYMSI--------------TGSKIK CG4224_Dmel LT---------R------PINGTDMVRR-MW--NRSFTGI--------------TGN-VT CG3216_Dmel -------------------RDGVNITRR-MW--NRTFEGI--------------TGH-VR KSGC_Mmus -------------------RDGRQLIST-LRAGQVTLQGI--------------TGP-VL HSER_Mmus -------------------VTGPKFARA-FR--NLTFQGF--------------AGP-VT CYGX_Mmus --------------------SGAHLGDH-VR--ALDVAGF--------------SQR-IR CYGF_Mmus --------------------SAASLVQH-SR--NMQFYGF--------------NQL-IK CYGD_Mmus -------------------VSGASVARQ-VR--EAQVSGF--------------CGV-L- ANPb_Mmus -------------------EDGLRIVEK-MQ--GRRYHGV--------------TGL-VV ANPa_Mmus -------------------TDGENITQR-MW--NRSFQGV--------------TGY-LK odr-1_Cele H----------T------A----------MS--GKAVTTK--------------YG-TFT gcy-9_Cele N----------V------HMNGSLIWSR-MT--NRQFIGM--------------TG-QVL gcy-8_Cele E----------N------LLNGRMMWQN-MR--KLKFVGMVGASG-------IASG-QVS gcy-7_Cele A----------Q------YRNATAFM-R-YF--PQSFIGM--------------SG-NVT gcy-6_Cele -----------Q------YKNGTAFP-R-KM--AGVFNGV--------------GG-TVA gcy-5_Cele ------------------VYGNLNLLMP-QM--VTSFDGM--------------TG-RVQ gcy-4_Cele ------------------VYGNLSLLIP-KF--TTAFEGM--------------TG-EVK gcy-3_Cele ------------------VYDDMSKLIP-QF--VTSFNGM--------------TG-LVA gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele S----------I------VQQLPYLWNH-VT--NTETQGY--------------SG-PVF gcy-23_Cele N----------S------YLNGKEVWNH-MR--RITFPGLVSNAG-------VTSG-TVM gcy-22_Cele ------------------NPTGTEFCEV-AK--GMEFLGF--------------TG-KVI gcy-21_Cele ------------------IYQSDIFYEY-LI--SRKIDSV--------------TGVTEF gcy-20_Cele S----------N------LKNGSFVL-S-NI--GMTFQGV--------------GGEAVT gcy-2_Cele ------------------VYDDVDVIVP-QF--VTSFQGM--------------TG-KVV gcy-19_Cele ------------------YLNDIDKING-AL--QLNFAGL--------------TG-EVS gcy-18_Cele A----------Y------VTNGQFIWNR-MR--RMKFEGVVSRSSSEENKDAGAIG-TVL gcy-17_Cele A----------E------IRNGTMIL-R-NI--GMTFEGV--------------GGGDLT gcy-15_Cele ------------------IYQSDIFYEH-LI--SRKVDSV--------------TGVTEY gcy-14_Cele A----------N------LKNGSFVL-S-DI--GMSFQGV--------------GGGTVT gcy-13_Cele E----------Q------IANGSNIVTR-GA--GIEFEGM--------------SG-VVR gcy-12_Cele DSYD-------P------TADGKAIIDR-IV--NKKYRSI--------------QGFDMR gcy-11_Cele -----------L------LRDPESLVQT-MS--GRGVTSL--------------LGYVTK gcy-1_Cele ------------------VYGDVDVLVH-QF--VTSFQGM--------------TG-HVV daf-11_Cele -------------------FNYVQPEKA-IS--SMSIPGP--------------FG-EIF C04H5.4_Cele K----------I------RIDGKALWN--MA--IRT------------------------ CYGF_Hsap --------------------GAASLVQH-SR--NMQFHGF--------------NQL-MR ANPb_Hsap -------------------EDGLRIVEK-MQ--GRRYHGV--------------TGL-VV ANPa_Hsap -------------------TDGENITQR-MW--NRSFQGV--------------TGY-LK CYGD_Hsap -------------------VSGAAVARH-IR--DAQVPGF--------------CGD-L- T01A4.1_Cele -------------------ENGAKKSLS-LK--NR------------------------- Npr1_Spur ------------------------------------------------------------ Npr2_Spur -------------------YDGHAVTKK-MW--NRTFDGL--------------YGK-VK Gcy3_Spur R-------------------NGTEILRR-IL--CRKHASI--------------TGRPKY Npr3_Spur -------------------SDGYVITRK-MW--GRSFQGI--------------SGT-VT Npr4_Spur -------------------CSRRQFLLR-YR--DTGQRGF--------------GGS-V- Gcy1_Spur Y-------------------DGEEVVST-LL--NSTYRSK--------------TDTFYQ Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque S-GVNITDVILE------RDDYDVITRH-LF--NTTLNGI--------------TG-ILT AqueK221_Aque L-GANLSEVSIA------SADKLNVIAT-ML--NTTFVGE--------------TG-RVM AqueK222_Aque ------------EVFIEVP----------------EINHM-------------------- HSER_Hsap LDDWGDVDST-MVLL--------------------------------------YT----- CG10738_Dmel IDENGDAAGN-YTVL--------------------------------------AR----- CG9783_Dmel TTANG------------------------------------------------------- Gyc32E_Dmel IDSNGDAEGN-YTVI--------------------------------------TL----- Gyc76C_Dmel IDQYGDSEGN-FSVL--------------------------------------AY----- CG4224_Dmel IDANGDRLSA-YSLL--------------------------------------DM----- CG3216_Dmel IDDNGDRDAD-YSIL--------------------------------------DL----- KSGC_Mmus LDSQGKRHVD-YSVY--------------------------------------AL----- HSER_Mmus LDDSGDIDNI-MSLL--------------------------------------YV----- CYGX_Mmus TDGKGRRLAQ-YVIL--------------------------------------DT----- CYGF_Mmus TDSNGNGISE-YVIL--------------------------------------DT----- CYGD_Mmus ---GRTEEPS-FVLL--------------------------------------DT----- ANPb_Mmus MDKNNDRETD-FVLW--------------------------------------AM----- ANPa_Mmus IDRNGDRDTD-FSLW--------------------------------------DM----- odr-1_Cele FDNSGSVLTN-YAVF--------------------------------------TI----- gcy-9_Cele MNNKAIRVPS-YATY--------------------------------------HA----- gcy-8_Cele MDDRAERAPL-YRGF--------------------------------------FV----- gcy-7_Cele INEKGTRNPT-LFLL--------------------------------------AL----- gcy-6_Cele IDEGGGLQPT-LFVL--------------------------------------TL----- gcy-5_Cele IGQNLYRVPT-YQLY--------------------------------------GL----- gcy-4_Cele LNEDLARKPL-YQVY--------------------------------------GL----- gcy-3_Cele INQNLSRMPL-YQLY--------------------------------------GL----- gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele IGNDGVRLPY-YEMH--------------------------------------MW----- gcy-23_Cele MDDIAERAPV-YAAF--------------------------------------YV----- gcy-22_Cele INQNSTRTPL-FVVY--------------------------------------NL----- gcy-21_Cele IDGYGAIVGS-IQIY--------------------------------------YH----- gcy-20_Cele LDESGSRIVQ-VYMF--------------------------------------AM----- gcy-2_Cele ISPNLTRMPI-FQLY--------------------------------------GL----- gcy-19_Cele INANNSRVPK-LMLY--------------------------------------AL----- gcy-18_Cele MDDVADRAPI-FSAF--------------------------------------YI----- gcy-17_Cele VDPDSARTSE-IIMI--------------------------------------GL----- gcy-15_Cele IDGYGAIVGS-MQIY--------------------------------------YH----- gcy-14_Cele LDDTGTRIVQ-VYMF--------------------------------------AL----- gcy-13_Cele MNGIGYRLPN-MNLA--------------------------------------NL----- gcy-12_Cele IDERGNSKGN-FSLL--------------------------------------SW----- gcy-11_Cele FNTNGVSQRE-YILW--------------------------------------AP----- gcy-1_Cele ISPNLTRMPI-FQLY--------------------------------------GL----- daf-11_Cele INSNGQRIAG-IREL--------------------------------------IIWCRGY C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap TDSNGNGISE-YVIL--------------------------------------DT----- ANPb_Hsap MDKNNDRETD-FVLW--------------------------------------AM----- ANPa_Hsap IDSSGDRETD-FSLW--------------------------------------DM----- CYGD_Hsap ---GGDEEPP-FVLL--------------------------------------DT----- T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur INENGDRDSE-YSLW--------------------------------------DM----- Gcy3_Spur IDARGDAYAD-ITVI--------------------------------------AV----- Npr3_Spur INENGDRSGD-YSLW--------------------------------------DM----- Npr4_Spur ISIRGDCDTS-ASSVSGFVHTAHHKQLADSGGICGPWVPPSGDIFTHTESNVDSL----- Gcy1_Spur FDENGDGVKP-YVLL--------------------------------------HL----- Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque FDRYCNRVANTFVIT--------------------------------------NF----- AqueK221_Aque FNNACNRLTNIFKVI--------------------------------------NM----- AqueK222_Aque ------------------------------------------------------------ HSER_Hsap -----SV----DTKKYKVL------------LTY-------D------------------ CG10738_Dmel -----GSV---RNGRNQTVL-----GLRP-VGTFI-----HR----N----SSL------ CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel -----QND---V-GSGASIGSLAKMSMQP-VGFFA-----YD----K------------- Gyc76C_Dmel -----KPH---K-WNNSNNMP-CNYHMVP-VAYFH-----------Q------------- CG4224_Dmel -----NP----TTGRFEIV------------AHF-------L------------------ CG3216_Dmel -----DP----INGKFSVV------------AHY-------S------------------ KSGC_Mmus -----QE----SGNRSLFL---------P-FLHY-------D------------------ HSER_Mmus -----SL----DTRKYKVL------------MKY-------D------------------ CYGX_Mmus -----DG----EGSQLVPT------------HIL-------D------------------ CYGF_Mmus -----NG----KEWELRGT------------YTV-------D------------------ CYGD_Mmus -----DA----SGEQLFAT------------HLL-------D------------------ ANPb_Mmus -----GDL---DSGDFQPA------------AHY-------S------------------ ANPa_Mmus -----DP----ETGAFRVV------------LNF-------N------------------ odr-1_Cele -----NP----AEMTFESIL--------T-LKSVA-----KS-------C---------- gcy-9_Cele -----I------NGTLKIVV--------E-LEAKN-----ND----RGQCEK-------- gcy-8_Cele -----SP----NSDSVLPMV--------H-MEPTM-----LD----NCDGIA-------- gcy-7_Cele -----DE----NNNNTRMA---------T--IY-------VE----N------------- gcy-6_Cele -----DS----NNNSSLIM---------T--VD-------VD----Q------------- gcy-5_Cele -----DE----KYEQVALV---------N--MTF------YN----S------------- gcy-4_Cele -----NS----EYDQISLI---------D--ISL------IN----D------------- gcy-3_Cele -----DE----QYEQTSLM---------N--LSF------AD----G------------- gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele -----RD-----GKAVH-VA--------N-VKPRE-----SDYCGGN------------- gcy-23_Cele -----PP----NSDTVRKVC--------E-LEPVM-----LT----NCDGTK-------- gcy-22_Cele -----DS----TDKEMIVM---------Q--ITED-----LD----D------------- gcy-21_Cele -----FSS---SSHNSY--------SLFP-CARLA-QSS-LL------------------ gcy-20_Cele -----NS----SLLPYMAA---------S--LL-------VN----V------------- gcy-2_Cele -----NS----DYEQVALA---------E--FTY------ID----P------------- gcy-19_Cele -----ND----KYDQASFM---------N--LTYS-----LN----G------------- gcy-18_Cele -----SP----NRDKVMKMV--------N-MESEL-----IS----NCDGLK-------- gcy-17_Cele -----NS----SRLPETYG---------K--LI-------IN----N------------- gcy-15_Cele -----FSS---SSHNSY--------SLFP-CARLA-QSS-LL------------------ gcy-14_Cele -----NT----SLLPYLAA---------S--LV-------IN----G------------- gcy-13_Cele -----DS----NATQRTVA---------Y--MD-------ID----S------------- gcy-12_Cele -----QKVAPIMNKSDP--------SYYP-LDHALDLTAIFV--EAP------------- gcy-11_Cele -----QQA----SSSNG---------PIP-LPEWATLAARM----LP------------- gcy-1_Cele -----NS----DYDQVALV---------D--FTY------TN----S------------- daf-11_Cele DVLVVDK----SLNSNNFIM--------P-LGTIS-----TD----K-KC---------- C04H5.4_Cele ----------------VSLI--------N-STVTS-----KN----CM------------ CYGF_Hsap -----NL----KEWELHST------------YTV-------D------------------ ANPb_Hsap -----GDL---DSGDFQPA------------AHY-------S------------------ ANPa_Hsap -----DP----ENGAFRVV------------LNY-------N------------------ CYGD_Hsap -----DA----AGDRLFAT------------YML-------D------------------ T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur -----TDT---ENGTFEVV------------GNF-------Y------------------ Gcy3_Spur -----KLG---EDVDETFGY-----IMHP-VATIK-----IT----N----STPEVEQSC Npr3_Spur -----TNT---EDGTFEVL------------ANY-------Y------------------ Npr4_Spur -----NH----TDWTT------------P-LALV------PD------------------ Gcy1_Spur -----IPI---PKGDGGA--TKDSLGMYP-IGTFN-----RE----N----GQW------ Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque -----VP----QSNATLPYR--------KERKGFV-----VI----C------------- AqueK221_Aque -----AP----STQSGVIID--------KKVGGFI-----FQ----D------------- AqueK222_Aque ------------------------------IAHVK-----------L------------- HSER_Hsap ---TH-----VNKT-YP------V-DMSPTFTWK------NSKLPNDITGRG-------- CG10738_Dmel ----S-----SISKALP------NLKLFSPIDW------VGGTRPAAAPRCGFG------ CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel --N-------SVIPEFR------YIKNDRPIQW------LNGRPPLAEPLCGFH------ Gyc76C_Dmel --G-------EEHPEY--------KLINGSIDWP-----SGGEKPADEPMCGFA------ CG4224_Dmel ---HN-----RLE----------F-EANKEIHWA----GDREEAPPDRPICGYD------ CG3216_Dmel ---GV-----HK--VYS------A-VHGKKIHWP----GGREEPPPDVPPCGFL------ KSGC_Mmus ---SF-----QKVI-RP------W-RNDSNTSWP------HGSLPEYKPGCGFH------ HSER_Mmus ---TH-----KNKT-IP------V-AENPNFIWK------NHKLPNDVPGLG-------- CYGX_Mmus ---TS-----TWQV---------Q-PLGKPIHFP------GGSPPAHDASCWFD------ CYGF_Mmus ---ME-----TELL---------R-FRGTPIHFP------GGRPTSADAKCWFA------ CYGD_Mmus ---PV-----LGSL---------R-SAGTPMHFP----R-GGPAPGPDPSCWFD------ ANPb_Mmus ---GA-----EKQI--W--------WTGRPIPWV------KGAPPLDNPPCAFD------ ANPa_Mmus ---GT-----SQEL--M------A-VSEHRLYWP------LGYPPPDIPKCGFD------ odr-1_Cele ---DT-----YNCFQLS------P-NKTSDLLWTL----KDMD-PPDD--CV-A------ gcy-9_Cele ---NE-----EMCSEHV------A-HETIQYYWPS----DSGKLPPAVPKCGFT------ gcy-8_Cele ---NK-----SGCYEIV------V-TDIMRDFWPS----VDRKMPKDEPDCGYR------ gcy-7_Cele ---M------SATFNAL------Y-SDE-GVMWAS---RKNNARPVDVPLCGFT------ gcy-6_Cele ---Q------EAVVTKH------Y-TNEATALWSH----RKGIRPPDQPICGYT------ gcy-5_Cele ---SS-------QLSRG------Y-SDEGRSVWHF----WDGTRPLDTPICGFS------ gcy-4_Cele ---TV-------NVVFN------Y-ADGNTEVWHF----WGGTRPPDTPVCGFL------ gcy-3_Cele ---TT-----VATISLA------Y-SNESSAVWHF----WGGIRPLATPICGFL------ gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ---MT-----KNCYEFL---------PSS-----P----LLEDLPPYTSDCGYD------ gcy-23_Cele ---TG-----NGCYELQ------V-TDLSTGFWPS----IDGSLPADEPACGFR------ gcy-22_Cele ---SKDPVASSVNYYIT------L-VATPAQIWDT----WGGTVPLSTPICGFT------ gcy-21_Cele ----------NTVWSLT------DYSEGLSIDFV------NKSAPKDTPVCGFY------ gcy-20_Cele ---S------EVVFTPF------Y-KS-ESELWS--------VRPLSRPKCGFT------ gcy-2_Cele ---IM-------NVTLS------Y-KEEGGAVWYF----YGNSRPLDIPICGFL------ gcy-19_Cele ---GA-------SVSLA------Y-TNE-ASLWYW----YGGKRPLSVPVCGFA------ gcy-18_Cele ---NK-----SGCFQLK------I-NDIKSGFWPS----EDGSMPLDEPICGYR------ gcy-17_Cele ---Q------SVHFEQL------Y-SDEVMDVWN------GRQRPKAKPTCGFT------ gcy-15_Cele ----------NTVWSLT------DYSEGLSIDFV------NKSAPKDTPVCGFY------ gcy-14_Cele ---S------EVEYTPF------Y-KS-EADLWS--------VRPLARPICGFS------ gcy-13_Cele ---T------SVNWTFA------I-IDQ-ALIWDA----YNGKLPQTRPECGYS------ gcy-12_Cele ---DK-----DRLPNL-------QFK-SSRIQWL------KGEPPPDEPVCGFH------ gcy-11_Cele ---DG-----KGNYSI-------IWKNLTQLGIF------NGELPQSKPECGFN------ gcy-1_Cele ---VM-----VPNVTLF------Y-KDEGGAVWSY----YGHSRPLDIPICGFL------ daf-11_Cele ---PD-----QACLNFV------L-NS-------T----SSFEPLKDVPLCGFH------ C04H5.4_Cele ----D-----PVCIELV------V-SDVVTKFWSS----PSGKLPDSEPECGFR------ CYGF_Hsap ---ME-----MELL---------R-FGGTPIHFP------GGRPPRADAKCWFA------ ANPb_Hsap ---GA-----EKQI--W--------WTGRPIPWV------KGAPPSDNPPCAFD------ ANPa_Hsap ---GT-----SQEL--V------A-VSGRKLNWP------LGYPPPDIPKCGFD------ CYGD_Hsap ---PA-----RGSF---------L-SAGTRMHFP----R-GGSAPGPDPSCWFD------ T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur --------------------------------------------PPDTPKCGFE------ Npr2_Spur ---LT-----SSGLKYT------P-VPGKPIKWP----GGATSPPRDTPFCGFN------ Gcy3_Spur LGNGT-----SFQWVYE------P-INGTFIPW------ISGSVPLAVPTCGFY------ Npr3_Spur ---GE-----TGVI---------E-TTGVKPVWP----GGGIGPPRDAPECGFE------ Npr4_Spur ---GV-----TSII-----------AHIRIGNWQAALHHIVTVRPR--SECGNKNCEELE Gcy1_Spur ----------GFEEALD------EDANVLRPVWH-----NRDEPPLDMPPCGFH------ Gcy2_Spur ---------------YA------A-HKGVDIQW------LGGSPPRAQPVCGFD------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque ---QN-----EPLIEFIDSSTGLK-SDVSTIVFH----NGLTAIPSDSISKFY------- AqueK221_Aque ---PE-----NSRILFYHNNETLS--PVNGLIFK----DGTTSVPLDYHQRKY------- AqueK222_Aque --G-------EMQMAIQ-------KSIYVTDHY------CGDGRCSDSEDCSSC------ HSER_Hsap -----------PQ----IL---MIAVFTLT--G----AVVL--LLL---V-A-------- CG10738_Dmel GEK---CVN-Y---T--------GEISAAIA-G-G--ALLL--LSL---V-S-------- CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel GEL---CPRKK---L-DW-----RYLVSGPL-C-A--LVVV--V-A---I-A-------- Gyc76C_Dmel NEL---CKKDD---T-HY----TSTVAAVVL-G-V--LLFC--SGV---I-T-------- CG4224_Dmel GAL---CPDN---SL-P-----GYAILSIVL-G-T--MVVV--MAV---C-F-------- CG3216_Dmel GNS-TDCVGN---FT-P-----RS----------I--NIL---F-I---Y-T-------- KSGC_Mmus NDL---CKTKPPTVA-GSM---TVTVTAVIP-T-V--TFLV--LASAAAITG-------- HSER_Mmus -----------PQ----IL---MIAVFTLT--G----ILVV--LLL---I-A-------- CYGX_Mmus PNT--LCIRG---VQ-PLG---S--LLTLTI-A-C--VLAL--VGG---F-L-------- CYGF_Mmus ERK--ICQGG---ID-PAL---A-MMVCFAL-L-I--ALLS--ING---F---------- CYGD_Mmus PDV--ICNGG---VE-PGL-----VFVGFLL-V-I--GMGL--TGA---F-L-------- ANPb_Mmus LDD-PSCDKT---PL-S-----TLAIVALGT-G-V--TFIM--FGV---S-S-------- ANPa_Mmus NED-PACNQD---HF-S-----TLEVLALVG-S-L--SLVS--FLI---V-S-------- odr-1_Cele KSS---CVN--------YI---PHIIAA-VV-I-V--TIIV--IA----I-V-------- gcy-9_Cele GAE---CD---------YR---PYFIGA-SL-L-A--FILT--VGP---L-S-------- gcy-8_Cele NER---CD---------YT---LIIIGA-AL-I-L--LFIV--AAV---S-A-------- gcy-7_Cele GNL---CPKSF--VD-EYL---IWVIVAIVV-L-F--LAIT--AAA---CGI-------- gcy-6_Cele GSL---CPANV--FF-QYI---GWFIAAIII-I-F--FTIM--GAI---LAF-------- gcy-5_Cele GRY---CPVQF--WD-QYG---VLIFVASIV-L-I--FLIC--IML---MCF-------- gcy-4_Cele GKS---CPLPI--FE-QYR---ALVIVAIAV-T-I--LILL--AII---ICM-------- gcy-3_Cele GNS---CPLPF--WE-QYG---ILIFVGAGV-F-L--IMIT--TNL---ICF-------- gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele NNL---CSDF--------H---VFMIAA-IV-F-S--ILLI--PMA---I-A-------- gcy-23_Cele NEK---CD---------YT---TLIIGG-CI-V-L--LIIL--LII---C-F-------- gcy-22_Cele GTD---CPKSF--TD-QYL---AIILGCTAA-A-L--VLII--AVI---STI-------- gcy-21_Cele GEN---CGPPA---N-NTF----IIVISVGV---A--VLIG--LAI---A-A-------- gcy-20_Cele GLE---CPADF--VK-EYL---VYTIIAAFI-V-I--LALL--AGC---AGL-------- gcy-2_Cele GKF---CPISF--WE-QYM---ILAIVSISV-I-V--LMVI--IMI---IGC-------- gcy-19_Cele GTD---CPQSF--VD-QYG---ALVFAIGGV-L-I--FAML--FVI---TCF-------- gcy-18_Cele GQR---CS---------YL---LEISVG-SL-I-I--LLIL--ISV---V-F-------- gcy-17_Cele GTQ---CPPDF--VR-DYL---VIVIIIVMF-L-I--FAVS--AAV---GAV-------- gcy-15_Cele GEN---CGPPA---N-NTF----IIVISVGV---A--VLIG--LAI---A-A-------- gcy-14_Cele GLE---CPPDF--VK-EYL---VYTIIAAVI-V-V--LALL--AGC---AGLLYTMQQKI gcy-13_Cele GKS---CPVNF--FV-DYL---YIVVIVAVI-I-V--LCCA--AAA---IAA-------- gcy-12_Cele GEN---CRKKG---I-FSY----LTVVVMIL---I--AVFS--LVL---TGF-------- gcy-11_Cele NEL---CPAGI---P-ESE----PSSFFDFS---K--NLY---LKK----RV-------- gcy-1_Cele GKS---CPVSF--WE-QYK---ILIFVAIAV-I-V--LMVL--IMI---IGC-------- daf-11_Cele GEI---CD---------QT---GVIIAIAVI-M-G--VLLM--FII---I-L-------- C04H5.4_Cele EEN---CD---------YT---QTIVIA-TA-V-V--CIIL--TVF---L-G-------- CYGF_Hsap EGK--ICHGG---ID-PAF---A-MMVCLTL-L-I--ALLS--ING---F---------- ANPb_Hsap LDD-PSCDKT---PL-S-----TLAIVALGT-G-I--TFIM--FGV---S-S-------- ANPa_Hsap NED-PACNQD---HL-S-----TLEVLALVG-S-L--SLLG--ILI---V-S-------- CYGD_Hsap PNN--ICGGG---LE-PGL-----VFLGFLL-V-V--GMGL--AGA---F-L-------- T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur NEL---CPAT---DN-S-KSKPSIKSLGVLG-RVLTSRFVN--TYL---F-F-------- Npr2_Spur NEN-PECQPDG--RL-S-----TLAISGIAA-A-S--VLLL--SFL---I-L-------- Gcy3_Spur GEF---CDTPY---R-PI-----VEIVSGVV-G-G--LLLV--ILI---V-A-------- Npr3_Spur NEL---CQSN---EL-P-----ILGLVGIAA-V-V--VVLA--AAG---I-L-------- Npr4_Spur GETCSNCPADC--GRCPLS---IGALSGIIA-G-C--IVVV--GSF---C-C-------- Gcy1_Spur GEL---CTNW----A--------LYLGASIP-T-F--LIIF--GGL---I-G-------- Gcy2_Spur GSL---CKTNY---T--------IHIVAGVI-A-G--IIML--TAI---I-A-------- Npr5_Spur ------------------------------------------------------------ AqueK220_Aque --------------T-RNN---RVIVGCLIL-E-L--VLYL--IMS---L-L-------- AqueK221_Aque --------------R-R-S---TSLTGAIVFNS-S--FLYI--LIA---V-C-------- AqueK222_Aque SVD---CCASL---P-SY----VVALSSSLS-S-V--IFLAIGLTI---I-L-------- HSER_Hsap ---------------------------------------------------LL-MLRKY- CG10738_Dmel ---------------------------------------------------LV-LYRNW- CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel ----------------------------------------------------L-LIKHY- Gyc76C_Dmel ---------------------------------------------------MS-IYRKW- CG4224_Dmel ---------------------------------------------------FF-GYRHY- CG3216_Dmel ---------------------------------------------------GT-DFRQM- KSGC_Mmus ---------------------------------------------------LM-LWRLRG HSER_Mmus ---------------------------------------------------LL-VLRKY- CYGX_Mmus ---------------------------------------------------AY-FIRL-G CYGF_Mmus ---------------------------------------------------AY-FIRR-R CYGD_Mmus ---------------------------------------------------AH-YLRH-R ANPb_Mmus ---------------------------------------------------FL-IFRKL- ANPa_Mmus ---------------------------------------------------FF-IYRKM- odr-1_Cele ----------------------------------------------------I-IVKQR- gcy-9_Cele ----------------------------------------------------Y-FIYLK- gcy-8_Cele ----------------------------------------------------F-FAQKI- gcy-7_Cele ---------------------------------------------------YF-SIQAR- gcy-6_Cele ---------------------------------------------------IY-LCHAK- gcy-5_Cele ---------------------------------------------------GF-MIRGR- gcy-4_Cele ---------------------------------------------------SS-KIRNR- gcy-3_Cele ---------------------------------------------------LF-MIKNR- gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ---------------------------------------------------FY-L---Q- gcy-23_Cele ----------------------------------------------------F-ILSRV- gcy-22_Cele ---------------------------------------------------VF-LVRSK- gcy-21_Cele ---------------------------------------------------AF-LYKRY- gcy-20_Cele ---------------------------------------------------LY-TMHMK- gcy-2_Cele ---------------------------------------------------LC-VISAK- gcy-19_Cele ---------------------------------------------------FY-VMRQK- gcy-18_Cele ----------------------------------------------------F-FLFRY- gcy-17_Cele ---------------------------------------------------FY-AIRQK- gcy-15_Cele ---------------------------------------------------AF-LYKRY- gcy-14_Cele SLKMDNFKILIMVKNTNFLKVEERKYTYAYGIAMAKSRKLKSQVFPFSITLLL-NFRMK- gcy-13_Cele ---------------------------------------------------FL-VIKAR- gcy-12_Cele ---------------------------------------------------TLNYIRSR- gcy-11_Cele ---------------------------------------------------VLKWI---- gcy-1_Cele ---------------------------------------------------LC-VISGK- daf-11_Cele ----------------------------------------------------T-TIRKCC C04H5.4_Cele ----------------------------------------------------I-WLRRA- CYGF_Hsap ---------------------------------------------------AY-FIRR-R ANPb_Hsap ---------------------------------------------------FL-IFRKL- ANPa_Hsap ---------------------------------------------------FF-IYRKM- CYGD_Hsap ---------------------------------------------------AH-YVRH-R T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ---------------------------------------------------IS-ICRKY- Npr2_Spur ---------------------------------------------------VL-VYRKI- Gcy3_Spur ---------------------------------------------------IT-VYRNW- Npr3_Spur ---------------------------------------------------FV-IYRKH- Npr4_Spur ---------------------------------------------------VI-GYFYW- Gcy1_Spur ---------------------------------------------------FF-IYRKR- Gcy2_Spur ---------------------------------------------------TI-VYRNW- Npr5_Spur ------------------------------------------------------------ AqueK220_Aque ---------------------------------------------------YI-IYVNKV AqueK221_Aque ---------------------------------------------------YF-VYVRHQ AqueK222_Aque ---------------------------------------------------FI-VWFYY- HSER_Hsap R-KDYELRQKKWSH-IPPENIFPLETNE-TNH------V-SL------------------ CG10738_Dmel R-YEQELDSLLWK--IDFREVQIHENER-EQQ---S-QK-QT-RSTH--------PLI-R CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel R-YEQTLAGLLWK--VDMKDVTVINLGE-YNNP--T-NK-NI-F-----------QIC-R Gyc76C_Dmel K-IELEIEGLLWK--IDPNEIKGYSGNE-IVSS-----P-SK-VSLM--------S---A CG4224_Dmel I-AEAEINSMSWK--VSLEDVMFRDAAE-RG----L-RG-SF-HSLV--------K-Q-S CG3216_Dmel K-LSKELNNMSWR--VRPDDVLIEMGGM-FG-S--K-GGLQR-LDVENISLQQFGI-H-S KSGC_Mmus K-VQSHPGDTWWQ--IRYDSITLLPQHK-LSHR--GTPV-SR-RNVS--------D-T-S HSER_Mmus R-RDHALRQKKWSH-IPSENIFPLETNE-TNH------I-SL------------------ CYGX_Mmus L-QQLRLLRGPHRILLTSQELTFLQRTPSRRRPHVD-SG-SE-S-RS------------- CYGF_Mmus I-NKIQLIKGPNRILLTLEDVTFINPHFGSKR------G-SR-ASVS--------F-Q-I CYGD_Mmus L-LHMQMASGPNKIILTLEDVTFLHPPGGSSRK-VV-QG-SR-SSLA--------T-R-S ANPb_Mmus M-LEKELASMLWR--IRWEELQFGNSDR-YH-K--G-AG-SR-LTLS--------L-R-G ANPa_Mmus Q-LEKELVSELWR--VRWEDLQPSSLER-HL-R--S-AG-SR-LTLS--------G-R-G odr-1_Cele R-HKLNIYKLTWK--VPKESLKIIVNKN-AD------AK-MQ-REL-E-------N-R-A gcy-9_Cele Q-KERLLYDMTWR--IPRESIKMLEGKS-KS------EH-----SL-A-------S-K-S gcy-8_Cele L-EKRALDKLPFR--IYRDDLQFIDEEQ-LK---------SM-LSL-G-------S-T-R gcy-7_Cele R-QEIERLNRLWQ--IPFIHLHQINSKQ-KGK---G-EH-SV-RSL-Q-------S-G-T gcy-6_Cele Q-QEVERQNALWQ--IPFKSMMTVTKKG---K---G-EH-SM-RSI-S-------S-V-P gcy-5_Cele R-AEQERLNSEWQ--IPSIQLIMPQKEK-R-----K-PN-SR-RSL-Q-------S-G-P gcy-4_Cele R-VEQSRLHSEWQ--IHAIKLRLPMHRR-A-----S-KS-SQ-ESETE-------S-A-S gcy-3_Cele R-EEQARINSEWQ--IPFVKLRELERK---S----K-GT-SK-RSL-Q-------S-A-P gcy-27_Cele ----TRKYKMTWK--VPKESLKIIVNKN-AD------AR-MQ-REL-E-------N-R-T gcy-25_Cele R-KEHLIQQMPWR--VPLDSISFDDNGG-SL-S-----A-S--RRV-S-------T-I-S gcy-23_Cele C-ENRALANTPWR--IYRDDFRTIQENE-MK---------SM-LSI-G-------S-S-K gcy-22_Cele R-QEEERLNQLWQ--VHFSSLVKPPQKN-T-------MH-SS-RSL-Q-------S-T-V gcy-21_Cele R-YERRLHSLFFM--IDRNQIILKKHTN-L-MS----QQ-SL-RSMA--------S---- gcy-20_Cele R-KEMERQDLLWQ--VAFVELQQVQSKS---R---A-EA-SM-HSF-A-------S-G-P gcy-2_Cele H-AEQARTNAEWQ--VPFVNLMESEKQI-RS----N-AT-SR-RSL-Q-------S-A-P gcy-19_Cele R-LERDRIDAEWQ--IPLVKLQAPPKRD-K-----E-RM-SK-RSL-Q-------S-G-P gcy-18_Cele C-ENKQLEKMPWR--IFHDDLQFIDEEQ-VK---------SM-MSV-G-------S-V-T gcy-17_Cele R-KEIERQDELWH--VEASHLKPISKKS---K---S-EA-SQ-RSF-A-------S-G-P gcy-15_Cele R-YERRLHSLFFM--IDRNQIILKKHTN-L-MS----QQ-SL-RSMA--------S---- gcy-14_Cele R-KEMERQDLLWQ--VPFIELQQVQSKS---K---A-EA-SM-HSF-A-------S-G-P gcy-13_Cele R-DEELRLDDQWI--VPHGMLQSIIKGR-K-E---S-HH-SS-RSL-Q-------S-N-S gcy-12_Cele R-FEKEL-SMIWK--IDPYEVRRVVGGV-NNES----TA-SLMQSDV--------M-QFA gcy-11_Cele A-YERRLESSYFL--VHRKHVQLVDMTK-FGSS--R-GG-SMIQSAM--------S---- gcy-1_Cele R-AERARINAEWQ--VPFAKLIESEKQV-RG----K-GA-SR-RSL-Q-------S-A-P daf-11_Cele NGSKGRSISNPWV--IPFQDVRFIDLTN-TE------GS-QH-MSI-Q-------S-L-Q C04H5.4_Cele C-ETSALDKMPWR--VFRDDVQILDEEQ-VK---------SV-VSL-N-------S-A-S CYGF_Hsap I-NKIQLIKGPNRILLTLEDVTFINPHFGSKR------G-SR-ASVS--------F-Q-I ANPb_Hsap M-LEKELASMLWR--IRWEELQFGNSER-YH-K--G-AG-SR-LTLS--------L-R-G ANPa_Hsap Q-LEKELASELWR--VRWEDVEPSSLER-HL-R--S-AG-SR-LTLS--------G-R-G CYGD_Hsap L-LHMQMVSGPNKIILTVDDITFLHPHGGTSRK-VA-QG-SR-SSLG--------A-R-S T01A4.1_Cele -----------------------------------------------KLSFGMVSF-K-S Npr1_Spur R-LERELSNMSWR--IRWEDISFNNKGD-KM-R--K-LG-SR-MSLA--------S-G-S Npr2_Spur R-LDAELLRMSWK--LSWDELVFPEETK-SG-Q--S-KF-SG--SFV------------T Gcy3_Spur K-YEQELASLLWK--IDYADIQTKRHN----G---S-TI-SA-ISKL------------- Npr3_Spur R-LDAELMSMSWK--VAWEELIFEEIGK-SV-A--T-AT-SG--SRA--------L---S Npr4_Spur R-QEKMFWDESWI--INYEDIKPDTGQR-G-----F-GG-SV-ISI-R-------G-D-C Gcy1_Spur A-YEAALDSLVWK--VDWSEVQTKATDT-NSQG-----F-SM-KN-----------MV-M Gcy2_Spur R-YEQALASLLWK--IDYNELEFKSIC---HG---S-RL-SI-ATHD------------- Npr5_Spur --------------------------------------------S-----------TV-- AqueK220_Aque D-KRANVYNESWI--YHDNDISYSIDQS-GV-N-----------IM-L------------ AqueK221_Aque D-KLAHIYSEAWL--YQQKDVKLTTGTF-AD-S-----------TL-S------------ AqueK222_Aque Q-KQKLFYDESWI--IDYSDLRLCSMMS-LINS-----R-IH-GETD--------N---V HSER_Hsap ----------KIDDD------K-------------------------------------- CG10738_Dmel TS--------QVS--LSSNPDA-------------------------------------- CG9783_Dmel -------KS--GSSATGSLA---------------------------------------- Gyc32E_Dmel QS--------ILV--------V-------------------------------------- Gyc76C_Dmel QS-------------YGSRW---------------------------------------- CG4224_Dmel SQ---------LTLMSEDMVSI-------------------------------------- CG3216_Dmel GR---------AS--IASF--T-------------------------------------- KSGC_Mmus TV--------KASADCGSLVKR-------------------------------------- HSER_Mmus ----------KIDDD------R-------------------------------------- CYGX_Mmus ---VVDGGSP-RSVTQGSARS--------------------------------------- CYGF_Mmus ISEVQSGRSPRLSFSSGSL----------------------------------------- CYGD_Mmus ASDIRS------------V----------------------------------------- ANPb_Mmus SS-------------YGSLMTA-------------------------------------- ANPa_Mmus SN-------------YGSLLTT-------------------------------------- odr-1_Cele SN----------T-DNAAALTS-------------------------------------- gcy-9_Cele QS----------SGSFSGSMNS-------------------------------------- gcy-8_Cele TK-----------M---SNMNY-------------------------------------- gcy-7_Cele S-----------TLSSR--TTV-------------------------------------- gcy-6_Cele S-----------TISSTRSSTL-------------------------------------- gcy-5_Cele S-----------TITGESKMTI-------------------------------------- gcy-4_Cele ET---------ENFTSKSGDTM-------------------------------------- gcy-3_Cele S-----------TITGESKVST-------------------------------------- gcy-27_Cele A-----------K-DEANALTS-------------------------------------- gcy-25_Cele TA--------RAS--YSSIF---------------------------------------- gcy-23_Cele TK-----------M---SNMSM-------------------------------------- gcy-22_Cele T-----------TST-K--VTI-------------------------------------- gcy-21_Cele -I--------HGSVVAASQTLRDS-HFFIEDYNNASSINASSIFNTGSTARAGPFGPIPG gcy-20_Cele S-----------TST-K--MTV-------------------------------------- gcy-2_Cele S-----------ISTGHSGVTT-------------------------------------- gcy-19_Cele S-----------NITDTSKMTF-------------------------------------- gcy-18_Cele TK-----------L---SNIQT-------------------------------------- gcy-17_Cele S-----------TST-K--LTV-------------------------------------- gcy-15_Cele -I--------HGSVVAASQTLRDS-HFFIEDYNNASSINASSIFNTGSTARAGPFGPIPG gcy-14_Cele S-----------TST-K--ITV-------------------------------------- gcy-13_Cele T-----------TTTG--TTGI-------------------------------------- gcy-12_Cele KT--------KTPWWSKAPVQG-------------------------------------- gcy-11_Cele -M--------RSQYEDSGPVGGATMNFYTNG------IRKAAIR------R-NQ----MQ gcy-1_Cele S-----------ISTGHSGVTT-------------------------------------- daf-11_Cele RN-----------MEEKQRLQS-------------------------------------- C04H5.4_Cele TK-----------M---SQVET-------------------------------------- CYGF_Hsap TSEVQSGRSPRLSFSSGSL----------------------------------------- ANPb_Hsap SS-------------YGSLMTA-------------------------------------- ANPa_Hsap SN-------------YGSLLTT-------------------------------------- CYGD_Hsap MSDIRS------------G----------------------------------------- T01A4.1_Cele GS--------GGS--VETI--A-------------------------------------- Npr1_Spur VE-------------SGTS-VW-------------------------------------- Npr2_Spur S--------------IGHG--T-------------------------------------- Gcy3_Spur -S--------LMT--TDSKNSV-------------------------------------- Npr3_Spur SK---------RS--MNEE--I-------------------------------------- Npr4_Spur DT--------SAS-SVSGFVHT-------------------------------------- Gcy1_Spur -S--------AIS--VIS------------------------------------------ Gcy2_Spur -S--------RVS--M--YADP-------------------------------------- Npr5_Spur -S--------VKG--KDA------------------------------------------ AqueK220_Aque -----------------SWLTY-------------------------------------- AqueK221_Aque -----------------SLLQI-------------------------------------- AqueK222_Aque SG-------------QGSVF-N-------------------------------------- HSER_Hsap ----------RR--DT---IQRLRQC----K--YDKKRVILKDLK-----HND--G--NF CG10738_Dmel ----------DFR-YT---TIFTPIG----L--YKGQLYAIKKVRK-----KS--V--DI CG9783_Dmel ----------R-H-NP---AHLDMRA----R--YNGDLVQLKEVNIN----GS----AEL Gyc32E_Dmel ----------GEP-NK---RSFTNIA----L--FRGNIVAMKKIHK-----KS--V--DI Gyc76C_Dmel --------------TN---QFVTSTG----R--LRGAVVRIKELKFP---R-K--R--DI CG4224_Dmel ----------N-G-DR---QIFIPVG----M--FRKSKVAIKPVE-----VDN--VQGLL CG3216_Dmel ----------S-L-PP---QVYTTIG----Q--FKGERVAIKKVN-----VKK--V--DL KSGC_Mmus ----------HQD-EE---LFFAPVG----L--YQGNQVALCYIG-----DEA--E--AW HSER_Mmus ----------RR--DT---IQRVRQC----K--YDKKKVILKDLK-----HSD--G--NF CYGX_Mmus ----------L-P-AF---LEHTNVA----L--YQGEWVWLKKFEAG----VA----PDL CYGF_Mmus ----------T-P-AT---YENSNIA----I--YEGDWVWLKKFPPG----DFGDI-KSI CYGD_Mmus ----------P-S-QP---QESTNVG----L--YEGDWVWLKKFPGE----HH----MAI ANPb_Mmus ----------H-G-KY---QIFANTG----H--FKGNVVAIKHVN-----KKR--I--EL ANPa_Mmus ----------E-G-QF---QVFAKTA----Y--YKGNLVAVKRVN-----RKR--I--EL odr-1_Cele ----------RRR-VF---GSYALVG----T--QRAEYVQFKQI-------RK--I--NF gcy-9_Cele ----------KQN-GL----IAAKQA----V--SNGVKLAIKRYQQ----VRN--I--TF gcy-8_Cele ----------G----S---RNHAIVG----T--NTH-AIYH-KYVQ----RRP--I--VF gcy-7_Cele ----------SFKT----ESRNFLFFSLQRE--SDYEPVVAKKHA------YR--P--RL gcy-6_Cele ----------SEVG----ETRNYLFFQIQND--VEMERVAAKKHS------IR--M--VF gcy-5_Cele ----------DG--GF---HENYTVQ----M--FEKDLVLTTKHH-------S--M--QM gcy-4_Cele ----------TS--EF---KETYTIQ----Y--LENDLVLTTAHQ-------V--Q--EL gcy-3_Cele ----------GS--EF---CENYEVK----M--FEKDMVLTMKFQ-------Y--M--NL gcy-27_Cele ----------RRR-VF---GSYALIG----T--QRAEFIQFRQI-------KH--I--DI gcy-25_Cele -----------SG-----N--VAEHA----I--VNKQKVSVKRHVQ----RRA--I--TF gcy-23_Cele ----------F----V---KHHAVVG----T--NTH-ASFH-LYPQ----RRP--I--VF gcy-22_Cele ----------NSKK----DTERHSFY----F--LNNDSVVARKHN------FR--A--TF gcy-21_Cele FGGVTG-ASEDEKWHQ---IPDFGVG----L--YEGRTVALKRIY-----RSD--V--EF gcy-20_Cele ----------ESRT----ETTNFIFY----H--YHQEVVAAKKHD------LL--V--LF gcy-2_Cele ----------VS--DF---CENYTMM----M--YEKEMVLTAKYQ-------Y--T--HL gcy-19_Cele ----------DN--TF----SNYSIF----Y--LDKEPVLSTAHP-------A--S--NL gcy-18_Cele ----------G----Q---KQHAIIG----V--NTH-TTYH-RYKQ----RRP--I--KF gcy-17_Cele ----------ESRT----ETTRFIFY----I--YQNEVVAANKHD------FR--P--QL gcy-15_Cele FGGVTG-ASEDEKWHQ---IPDFGVG----L--YEGRTVALKRIY-----RSD--V--EF gcy-14_Cele ----------ESRS----ETINFIFY----Y--YQQDILAAMKHD------LI--L--QF gcy-13_Cele ----------SSRSVFFPETETQGYF----V--YMNEPVLARKYQ------LR--V--PI gcy-12_Cele -------------------TGMRGLA----S--YKGTLVGLKDLMYG---RKP--K--DL gcy-11_Cele -RSDKGPAANRDEWLE---IVDWHLA----K--YENTLVTVRKIN-----KTQ--L--KL gcy-1_Cele ----------VS--DF---CENYTMM----M--YEKEMVLTAKYQ-------Y--T--HL daf-11_Cele ----------LAR--------TKHIA----T--VDQVYVLADKYVM----RDK--L--RY C04H5.4_Cele ----------K---LI---KNHAIVG----V--NTH-AVYD-LYEQ----RQN--I--RF CYGF_Hsap ----------T-P-AT---YENSNIA----I--YEGDWVWLKKFSLG----DFGDL-KSI ANPb_Hsap ----------H-G-KY---QIFANTG----H--FKGNVVAIKHVN-----KKR--I--EL ANPa_Hsap ----------E-G-QF---QVFAKTA----Y--YKGNLVAVKRVN-----RKR--I--EL CYGD_Hsap ----------P-S-QH---LDSPNIG----V--YEGDRVWLKKFPGD----QH----IAI T01A4.1_Cele ----------Q-N-NT---QIYTKTA----I--FKGVVVAIKKLNIDPKKYPR--L--DL Npr1_Spur ----------G-N-NQ---QIFTVTG----F--YKGNVIAIKRVN-----RQR--V--EL Npr2_Spur ----------S-H-HR---QMFATVA----N--YKGRLVVIRRIE-----KTK--L--DL Gcy3_Spur ----------DPY-RC---QIFTEVG----T--YKNMLVAIKKIHK-----RH--V--DL Npr3_Spur ----------Q-D-GG---QIFATVA----R----------------------------- Npr4_Spur ----------A-H-HK---QVFAQTG----I--YNGQTVAVKMIA-----KNS--F--TL Gcy1_Spur ----------NAE-KQ---QIFATIG----T--YRGTVCALHAVHK-----NH--I--DL Gcy2_Spur ----------LSG-RG---QVFTRVG----R--YNHTLVAIKPVHK-----KH--I--EM Npr5_Spur ----------N-K-KG---K-NFAFA----T--YNSHTVVLRKVEV-----HD--F--NL AqueK220_Aque -----------NG-D-------QTIG----QINNAGNAVYIHKAK-----LNM--S--QL AqueK221_Aque ----------LQP-NL---QEDSNIG----E--INGKIVKVHKMK-----MNI--S--TL AqueK222_Aque ----------LNG-NR---QIFIPTG----V--YEGKTVAIKKLNYR---SRE--L--QL HSER_Hsap --T--------------------------------------------------------- CG10738_Dmel --T--------------------------------------------------------- CG9783_Dmel --R--------------------------------------------------------- Gyc32E_Dmel --T--------------------------------------------------------- Gyc76C_Dmel --S--------------------------------------------------------- CG4224_Dmel --T--------------------------------------------------------- CG3216_Dmel --T--------------------------------------------------------- KSGC_Mmus VKK--------------------------------------------------------- HSER_Mmus --S--------------------------------------------------------- CYGX_Mmus --R--------------------------------------------------------- CYGF_Mmus --K--------------------------------------------------------- CYGD_Mmus --R--------------------------------------------------------- ANPb_Mmus --T--------------------------------------------------------- ANPa_Mmus --T--------------------------------------------------------- odr-1_Cele --P--------------------------------------------------------- gcy-9_Cele --P--------------------------------------------------------- gcy-8_Cele --N--------------------------------------------------------- gcy-7_Cele ------------------------------------------------------------ gcy-6_Cele --DN-------------------------------------------------------- gcy-5_Cele --N--------------------------------------------------------- gcy-4_Cele --S--------------------------------------------------------- gcy-3_Cele --N--------------------------------------------------------- gcy-27_Cele --T--------------------------------------------------------- gcy-25_Cele --S--------------------------------------------------------- gcy-23_Cele --N--------------------------------------------------------- gcy-22_Cele --T--------------------------------------------------------- gcy-21_Cele --T--------------------------------------------------------- gcy-20_Cele --D--------------------------------------------------------- gcy-2_Cele --T--------------------------------------------------------- gcy-19_Cele --I--------------------------------------------------------- gcy-18_Cele --I--------------------------------------------------------- gcy-17_Cele --TDVERSELRQVWPRDEMVTSHLFHYARRKVTSHVRHFVIFWHFHSKKLTTRGRRDFRA gcy-15_Cele --T--------------------------------------------------------- gcy-14_Cele --D--------------------------------------------------------- gcy-13_Cele --F--------------------------------------------------------- gcy-12_Cele --T--------------------------------------------------------- gcy-11_Cele --T--------------------------------------------------------- gcy-1_Cele --T--------------------------------------------------------- daf-11_Cele --D--------------------------------------------------------- C04H5.4_Cele --T--------------------------------------------------------- CYGF_Hsap --K--------------------------------------------------------- ANPb_Hsap --T--------------------------------------------------------- ANPa_Hsap --T--------------------------------------------------------- CYGD_Hsap --R--------------------------------------------------------- T01A4.1_Cele --S--------------------------------------------------------- Npr1_Spur --N--------------------------------------------------------- Npr2_Spur --T--------------------------------------------------------- Gcy3_Spur --T--------------------------------------------------------- Npr3_Spur ------------------------------------------------------------ Npr4_Spur --D--------------------------------------------------------- Gcy1_Spur --T--------------------------------------------------------- Gcy2_Spur --S--------------------------------------------------------- Npr5_Spur --T--------------------------------------------------------- AqueK220_Aque --N--------------------------------------------------------- AqueK221_Aque --D--------------------------------------------------------- AqueK222_Aque --T--------------------------------------------------------- HSER_Hsap -----------------------------------------------EKQKI-------- CG10738_Dmel -----------------------------------------------REMKK-------- CG9783_Dmel -----------------------------------------------TKAMD-------- Gyc32E_Dmel -----------------------------------------------RSIRK-------- Gyc76C_Dmel -----------------------------------------------REIMK-------- CG4224_Dmel -----------------------------------------------RSLML-------- CG3216_Dmel -----------------------------------------------PQLLW-------- KSGC_Mmus -----------------------------------------------PTVRR-------- HSER_Mmus -----------------------------------------------EKQKI-------- CYGX_Mmus -----------------------------------------------PSSLS-------- CYGF_Mmus -----------------------------------------------SSASD-------- CYGD_Mmus -----------------------------------------------PATKT-------- ANPb_Mmus -----------------------------------------------RQVLF-------- ANPa_Mmus -----------------------------------------------RKVLF-------- odr-1_Cele -----------------------------------------------ETTLD-------- gcy-9_Cele -----------------------------------------------KSELR-------- gcy-8_Cele -----------------------------------------------RADKTLIQLAKNF gcy-7_Cele ----------------------------------------------DDDKCT-------- gcy-6_Cele ---------------------------------------------KTCATMR-------- gcy-5_Cele -----------------------------------------------KEEKE-------- gcy-4_Cele -----------------------------------------------QAEMM-------- gcy-3_Cele -----------------------------------------------KADMD-------- gcy-27_Cele -----------------------------------------------NASLD-------- gcy-25_Cele -----------------------------------------------RQEME-------- gcy-23_Cele -----------------------------------------------RQDLQ-------- gcy-22_Cele -----------------------------------------------KNDRA-------- gcy-21_Cele -----------------------------------------------RSIRL-------- gcy-20_Cele -----------------------------------------------ANQKS-------- gcy-2_Cele -----------------------------------------------KADKE-------- gcy-19_Cele -----------------------------------------------RTDYD-------- gcy-18_Cele -----------------------------------------------KEDMQ-------- gcy-17_Cele CLKPARLTPAFRLFSTFLCFVEAGGGLLKVRQIGVLTPTSMPYLKPKLSYFS-------- gcy-15_Cele -----------------------------------------------RSNRL-------- gcy-14_Cele -----------------------------------------------AEQKA-------- gcy-13_Cele -----------------------------------------------KQDRS-------- gcy-12_Cele -----------------------------------------------REAKK-------- gcy-11_Cele -----------------------------------------------REMKQ-------- gcy-1_Cele -----------------------------------------------KADKE-------- daf-11_Cele -----------------------------------------------KIDIN-------- C04H5.4_Cele -----------------------------------------------REDLI-------- CYGF_Hsap -----------------------------------------------SRASD-------- ANPb_Hsap -----------------------------------------------RQVLF-------- ANPa_Hsap -----------------------------------------------RKVLF-------- CYGD_Hsap -----------------------------------------------PATKT-------- T01A4.1_Cele -----------------------------------------------RAQLM-------- Npr1_Spur -----------------------------------------------RNVLM-------- Npr2_Spur -----------------------------------------------REVLK-------- Gcy3_Spur -----------------------------------------------RSVRK-------- Npr3_Spur ------------------------------------------------------------ Npr4_Spur -----------------------------------------------KRIRK-------- Gcy1_Spur -----------------------------------------------RAVRT-------- Gcy2_Spur -----------------------------------------------R------------ Npr5_Spur -----------------------------------------------KAIKR-------- AqueK220_Aque -----------------------------------------------VKMRQ-------- AqueK221_Aque -----------------------------------------------LNLRK-------- AqueK222_Aque -----------------------------------------------KTLRK-------- HSER_Hsap --------------------ELNKLL-QIDYYNLTKFYGTVKLD----------TMI-FG CG10738_Dmel --------------------ELKLLR-DARHDNICAFIGACTDPP----------NI-CI CG9783_Dmel --------------------LLVMAH-GLRHENINPLIGWLSDP----------NRT-AM Gyc32E_Dmel --------------------ELKLMR-EVRHENIINFIGASTDHG----------SV-II Gyc76C_Dmel --------------------EMRLLR-ELRHDNINSFIGASVEP----------TRI-LL CG4224_Dmel --------------------ELKRMK-DLQHDHLVKFYGACLDQ----------RRS-FL CG3216_Dmel --------------------EIKQAR-DVSHENTVRFVGACIDLPR--------PTV-LI KSGC_Mmus --------------------EVCLMC-ELKHENIVPFFGVCTEP----------PNI-CI HSER_Mmus --------------------DLNKLL-QSDYYNLTKFYGTVKLD----------TRI-FG CYGX_Mmus --------------------FLRKLR-EMRHENVTAFLGLFVGP----------GVS-AM CYGF_Mmus --------------------VFEMMK-DLRHENVNPLLGFFYDS----------GMF-AI CYGD_Mmus --------------------AFSKLR-ELRHENVALYLGLFLAGTADSPATPGEGIL-AV ANPb_Mmus --------------------ELKHMR-DVQFNHLTRFIGACIDP----------PNI-CI ANPa_Mmus --------------------ELKHMR-DVQNEHLTRFVGACTDP----------PNI-CI odr-1_Cele --------------------YLYSLK-QLQHDNLAKFYGIQVNDDI--------MTM-TI gcy-9_Cele --------------------LLKELK-ICENDNLNKFYGISFNQQ---------NEF-IV gcy-8_Cele SQNPKEAGLPNYFKHLFYDRNHIQMK-AAVHDNINPFLGMVWNER---------EEM-LL gcy-7_Cele --------------------FMRSLR-NLDQDNLNRFIGLCLDG----------PQM-LS gcy-6_Cele --------------------QVVEMR-LIDHANLNKFIGMSLDA----------PQL-YS gcy-5_Cele --------------------KFVKLR-KLEHDNLNKFIGLSIDG----------PQF-VA gcy-4_Cele --------------------KFVKLR-KLDHENLNKFIGLSIDG----------SRF-VS gcy-3_Cele --------------------KFVKLR-KLDHENLNKFIGLSIDS----------SQF-IS gcy-27_Cele --------------------FLYNLK-QLKHDNLANFYGIQLNDDL--------NTM-TI gcy-25_Cele --------------------MLNQLK-YMSHTNINPFTGICFNQG---------SEL-IV gcy-23_Cele --------------------LLNQMK-QAVHDNLNPFLGMSFNEK---------EEM-VV gcy-22_Cele --------------------MFRKMR-NVDNDNLCKFIGLSLDS----------PTL-IS gcy-21_Cele --------------------EIAKLQ-ESVNSNVIEFVGMVVQS----------PDV-FV gcy-20_Cele --------------------EFRQMR-NFDNDNLNKFIGLCLDG----------PQL-LS gcy-2_Cele --------------------RFVKMR-KLDHENINRFIGLSIDS----------AHF-IA gcy-19_Cele --------------------TFVRLR-KLDHENVNKFVGMSIDG----------PEY-LA gcy-18_Cele --------------------LLTQMK-QAVHDNLNPFLGAAFNEK---------EEM-LV gcy-17_Cele --------------------SMHHMR-SLDHDNLNKFIGLCLNS----------QQL-LS gcy-15_Cele --------------------EIAKLQ-ESVNSNVIEFVGMVVQS----------PDV-FV gcy-14_Cele --------------------EFRQMR-NFDNDNLNKFIGLCLDG----------PQL-FS gcy-13_Cele --------------------ELRMLR-SIEHDNVNRFIGLSIDG----------PVY-MS gcy-12_Cele --------------------ELRAMR-QLAHPNVNNFLGIIVCQ----------YSV-TV gcy-11_Cele --------------------EIDLLM-NETHENLNRFFGLINES----------DLI-FT gcy-1_Cele --------------------RFVKMR-KLDHENINRFIGLSIDS----------AHF-IS daf-11_Cele --------------------LLYQMKSHLQHDNLNSFVGITIDKA---------SHM-YI C04H5.4_Cele --------------------LLTKMK-QAVHDNINPFIGVSFNEK---------SEL-LL CYGF_Hsap --------------------VFEMMK-DLRHENINPLLGFFYDS----------GMF-AI ANPb_Hsap --------------------ELKHMR-DVQFNHLTRFIGACIDP----------PNI-CI ANPa_Hsap --------------------ELKHMR-DVQNEHLTRFVGACTDP----------PNI-CI CYGD_Hsap --------------------AFSKLQ-ELRHENVALYLGLFLARGAEGPAALWEGNL-AV T01A4.1_Cele --------------------ELKKMK-DLQHDHITRFTGACIDF----------PHY-CV Npr1_Spur --------------------EIKHVR-DLQHDHVIKFIGACIDA----------PNI-SI Npr2_Spur --------------------ELNYMR-QVEHNNLVRFVGACVDA----------PNI-SI Gcy3_Spur --------------------ELKIIR-DLRHPHLNQFIGACVDPP----------NI-CT Npr3_Spur ----------------------YKMR-NLEHTNVVRFVGACVDP----------PDQ-AI Npr4_Spur --------------------EVKQVR-DLQHSNLCKFAGGCIEV----------PNV-SI Gcy1_Spur --------------------ELKIMR-DMRHDNICPFIGACIDRP----------HI-SI Gcy2_Spur ------------------------------------------------------------ Npr5_Spur --------------------ELKEMR-WLVHDNINRFLGLCFPSTS-------GDMF-YH AqueK220_Aque --------------------KILTIL-DFKHDNICPFVGGILQG----------SLITGL AqueK221_Aque --------------------TMLQIL-NFDHENICPFIGCILQG----------PTIVGM AqueK222_Aque --------------------EVMQIR-SLDHANVCRFIGATLRSS---------ENV-II HSER_Hsap VIEYCERGSL-REVLNDTISYPDGTF--MDWEFKISVLYDIA-------KGMSYLHS-SK CG10738_Dmel ISEYCTRGSL-KDILEN-----EDVK--LDNMFIASMVADII-------RGVIYLHD-SP CG9783_Dmel VFDYCSRGSL-QDVLIM-----DEIK--LDWSFRLSLLTDLV-------RGMRYLHT-SP Gyc32E_Dmel FTTYCARGSL-EDVLAN-----EDLH--LDHMFISSLVSDIL-------KGMIYLHD-SE Gyc76C_Dmel VTDYCAKGSL-YDIIEN-----EDIK--LDDLFIASLIHDLI-------KGMIYIHN-SQ CG4224_Dmel LTEYCPKGSL-QDILEN-----EQFQ--LDWMFRLSLMHDIV-------RGMQFLHS-SD CG3216_Dmel LTEYCSRGSL-KDVLEN-----EAIE--LDWNFRMSLIHDIV-------KGMNYLHN-SD KSGC_Mmus VTQYCKKGSL-QDVMRN-----SDHE--IDWIFKLSFAYDIV-------NGLLFLHG-SP HSER_Mmus VVEYCERGSL-REVLNDTISYPDGTF--MDWEFKISVLNDIA-------KGMSYLHS-SK CYGX_Mmus VLEHCARGSL-EDLLQN-----ENLR--LDWTFKASLLLDLI-------RGLRYLHH-RR CYGF_Mmus VSEFCSRRSL-EDILTN-----DDVK--LDWMFKSSLLLDLI-------KGMKYLHH-RE CYGD_Mmus VSEHCARGSL-HDLLAQ-----REIK--LDWMFKSSLLLDLI-------KGMRYLHH-RG ANPb_Mmus VTEYCPRGSL-QDILEN-----DSIN--LDWMFRYSLINDLV-------KGMAFLHN-SI ANPa_Mmus LTEYCPRGSL-QDILEN-----ESIT--LDWMFRYSLTNDIV-------KGMLFLHN-GA odr-1_Cele LHTLVERGTL-EEFCLD-----RDFG--MDDTFKSAFMRDIL-------KGLQYLHK-SS gcy-9_Cele MWVLCSRGSL-EDILFN-----DELK--LGRNFQVSFAKDVV-------KGLNFLHT-SP gcy-8_Cele VWKFCSRGTL-QDIIYN-----ESIQ--LDTKFHGAFIRDIL-------AGLEYLHA-SQ gcy-7_Cele VWRFCSRGSI-ADVILK-----ATIQ--MDNFFIYSLIKDMV-------HGLVFLHG-SM gcy-6_Cele VWRFCSRGSL-ADVIRK-----ASMQ--MDGFFIYSLMKDII-------NGLTWIHE-SS gcy-5_Cele VWKMCSRGSL-QDIIAR-----GNFS--MDGFFMFCIITDIA-------EGMNFLHK-SF gcy-4_Cele VWKMCSRGSL-QDIISK-----GSFS--MDYFFMFCMIRDIA-------EGLHYIHK-SF gcy-3_Cele VTKLCSRGSL-LDILYK-----GNFS--MDFFFMYCIIKDVA-------EGMSYLHK-SF gcy-27_Cele LHALVERGTL-EEFCLD-----RDFG--MDETFKSAFMRDIL-------KGLQYLHL-SP gcy-25_Cele MWQFTTRYSL-EDLIFV-----KEQK--FGRNFQSTFIKHIV-------HGINYIHN-SS gcy-23_Cele LWKFCSRGTI-QDMIYN-----QEVS--LDSKFHGAFIRDIT-------LGLEYLHS-SI gcy-22_Cele IWRYCSRGSL-QDVIAK-----GSLQ--MDWFFKYSLMRDVA-------DAIYYLHH-SP gcy-21_Cele VYELAQRGSL-KDILDN-----DDMP--LDDVFRSQMTKDII-------AGLEYLHS-SP gcy-20_Cele LWRFCSRGSL-SDVISK-----SSMQ--MDSFFMFSLIRDIS-------NGLYFIHS-SF gcy-2_Cele VTKLCSRGSL-QDILSR-----GNFS--MDYFFMFCIIRDVA-------KGLEYLHK-TF gcy-19_Cele VWKLCMRGSL-QDIIGQ-----GNFS--IDPFFMFCVIRDMA-------EGLKYLHN-SF gcy-18_Cele LWKFCSRGTI-QDIIYN-----ANVV--LDEKFHGAFVRDIT-------LGLEYLHA-SP gcy-17_Cele IWRYCSRGSL-ADVISR-----SSMQ--MDSFFMLSLIRDIA-------NGLGFIHT-SM gcy-15_Cele VYELAQRGSL-KDILDN-----DDMP--LDDVFRSQMTKDII-------AGLEYLHS-SP gcy-14_Cele LWRFCSRGSL-SDVISK-----SSMQ--MDSFFMFSLIRDIS-------NGLLFIHN-SF gcy-13_Cele FWRYCSRGSI-KDVIAK-----SSIN--MDGFFIYCLIKDIASVSRHENPGLQYIHH-SP gcy-12_Cele VREYCSKGSL-HDILRN-----ENLK--LDHMYVASFVDDLV-------KGMVYIHD-SE gcy-11_Cele IHSYGPRKSL-MDLLRN-----DDLR--LDRMFKVSFVEDVV-------KGLQFLHEGSK gcy-1_Cele VTKLCSRGSL-QDILSR-----GNFS--MDYFFMFCIIRDVA-------KGLEYLHK-TF daf-11_Cele IWNQCFRGSL-HDHIFT-----KERQRGTATRFEGLFLRDIL-------KGLEYIHA-SA C04H5.4_Cele LWKFCSRGTL-QDVIYC-----EKFA--MDEKFQGAFVRDIT-------MGLEYLHS-SP CYGF_Hsap VTEFCSRGSL-EDILTN-----QDVK--LDWMFKSSLLLDLI-------KGMKYLHH-RE ANPb_Hsap VTEYCPRGSL-QDILEN-----DSIN--LDWMFRYSLINDLV-------KGMAFLHN-SI ANPa_Hsap LTEYCPRGSL-QDILEN-----ESIT--LDWMFRYSLTNDIV-------KGMLFLHN-GA CYGD_Hsap VSEHCTRGSL-QDLLAQ-----REIK--LDWMFKSSLLLDLI-------KGIRYLHH-RG T01A4.1_Cele VTEYCPKGSL-EDILEN-----EKIE--LDKLMKYSLLHDLV-------KGLFFLHN-SE Npr1_Spur MTEYCPKGSL-QDILEN-----DSIE--LDELFKYSLMYDIV-------KGMLYLHN-SV Npr2_Spur ISEYCPKGSL-QDIVEN-----DALK--LDNMFKNSLITDVM-------RGLHYLHS-SV Gcy3_Spur ITEYCPKGSL-QDILEN-----DEVK--LDSMFIASLIGDIL-------KGLSCLHA-SE Npr3_Spur LTEYCPRGSL-QDILEN-----DQLK--LDLMFRQSLLMDAV-------RGLNYIHD-SV Npr4_Spur ITEYCPKGAL-SDVLLN-----EDVP--LNWSFRFSFCMDVA-------RGMHYMHN-NK Gcy1_Spur LMHYCAKGSL-QDILEN-----DDIK--LDSMFLSSLIADLV-------KGIVYLHS-SE Gcy2_Spur ----CLRKELKVDILEN-----DDIK--LDEMFIASLVSDIV-------KGMRHLHS-TE Npr5_Spur VSEFSPKGSL-KSILAN-----DDVN--LDLSFKASFIRDLA-------RGMQFLHA-SE AqueK220_Aque MYEYCTRGSL-YDLLTN-----PHIG--FNKSFRQSFAIDCS-------EGLAYLHG-RK AqueK221_Aque MHEYCSHGSL-YEVLRN-----PNIV--FDKQFRVLFATDII-------KGLTYLHS-HK AqueK222_Aque LTEYCPKGSL-NDVLQN-----DDIP--LNWGFRFSFVTDIS-------RGLAYLHS-KR : : . . . .: :* HSER_Hsap TEVHGRLKSTNCVVDSRMVVKITDFGCNSILPP--------------------------- CG10738_Dmel IRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSS-------------TD------- CG9783_Dmel LRVHGALTSRNCVVDARWVLKITDYGLNSFYESQGLP----------------------- Gyc32E_Dmel IISHGNLRSSNCLIDSRWVCQISDFGLHELKAGQEEP---------------N------- Gyc76C_Dmel LVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENES-------------I-------- CG4224_Dmel IRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLE-------------SD------- CG3216_Dmel VAAHGKLRSCNCLIDGRFVLKISDFGLRTLTTPSDFV----------------------- KSGC_Mmus LRSHGNLKPSNCLVDSHMQLKLSGFGLWEFKHGSTWR--------------SY------- HSER_Mmus IEVHGRLKSTNCVVDSRMVVKITDFGCNSILPP--------------------------- CYGX_Mmus F-PHGRLKSRNCVVDTRFVLKITDHGYAEFLESHCSS----------------------- CYGF_Mmus F-IHGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRLS----------------------- CYGD_Mmus V-AHGRLKSRNCVVDGRFVLKVTDHGHGRLLEAQRVL----------------------- ANPb_Mmus ISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAE----------------PD------- ANPa_Mmus IGSHGNLKSSNCVVDGRFVLKITDYGLESFRDPE-----------------PE------- odr-1_Cele IGYHGHLQASTCLIDINWVLKLTLYGVSNFMSDQLDAEN---------IKVPE------- gcy-9_Cele LLHHGMLCLQNCLVDSNWTVKLTNFATEAVIFEKLDHNELRPFINTDSESADDVS----- gcy-8_Cele IGYHGSLTPWSCLIDRNWMIKLTDYGIADPLERWEKSQSI----SRDGLTSDD------- gcy-7_Cele VGYHGMLTSKCCLIDDRWQVKISNYGLQDLRSPE-------------------------- gcy-6_Cele HEFHGMLTSKNCLLNDRWQLKITDFGLRIFRTHD-------------------------- gcy-5_Cele LHLHGNLRSATCLVNDSWQVKLTDFGLGALLEEH-------------------------- gcy-4_Cele LRHHGNLRSATCLVNDSWQVKLADFGLQFLQDEE-------------------------- gcy-3_Cele LRLHGNLRSATCLVNDSWQVKLAEFGFDQLLEEI-------------------------- gcy-27_Cele VAYHGHLHAATCLIDINWVLKIALYGVTNFVCDNFDAEN---------ITMPD------- gcy-25_Cele IKVHGALYLSNCVVDSYWVVKLTDFGIKGILKERTNHKE---------LAPSS------- gcy-23_Cele IGYHGSLTPWSCLIDRNWMIKLTDYGIANPLERWEKLGLI----STETLKEGD------- gcy-22_Cele IGPHGWLSSSTCLVDERWQVKVSFFGLSAIKQYE-------------------------- gcy-21_Cele IGCHGRLKSTNCLIDARWMVRLSSFGLRELRGEETWQQ-------------ED------- gcy-20_Cele LKCHGQLTSRCCLIDDRWQIKISGFGLKSVRTFE-------------------------- gcy-2_Cele LRLHGNLRSATCLVNDSWQVKLAEYGMDNLVEEQ-------------------------- gcy-19_Cele LHVHANLRSGTVLVNESWQAKLTDFGLGTLAEEK-------------------------- gcy-18_Cele IGYHGSLTPWCCLIDRNWMVKLSDYGIANPLERWEKQGAI----EIAAAKDSD------- gcy-17_Cele LHFHGYLSSRSCLIDDRWQVKISDFGLNEVRGMD-------------------------- gcy-15_Cele VGCHGRLKSTNCLIDARWMVRLSSFGLRELRGEETWQQ-------------ED------- gcy-14_Cele LKCHGHLTSRCCLIDDRWQIKISGYGLKSVRTFE-------------------------- gcy-13_Cele IKQHGSLTSECCYINDRWQVKIGSYGLSFMQGVE-------------------------- gcy-12_Cele LKMHGNLKSTNCLITSRWTLQIADFGLRELREGIMYDS-------------S-------- gcy-11_Cele IGYHGNLKSSNCIVDAYWRIKLSNYGMEQIRVEEPESK-------------PD-VFYDLV gcy-1_Cele LRLHGNLRSATCLVNDSWQVKLAEYGMDNLVEEQ-------------------------- daf-11_Cele IDFHGNLTLHNCMLDSHWIVKLSGFGVNRLLVKWKTSGQ---------IFTED-H----- C04H5.4_Cele IGYHGGLACWSVLIDKNWMLKLTDYAVCDPLKRWEKHGRI-------NCKVDN------- CYGF_Hsap F-VHGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRLS----------------------- ANPb_Hsap ISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAE----------------PD------- ANPa_Hsap ICSHGNLKSSNCVVDGRFVLKITDYGLESFRDLD-----------------PE------- CYGD_Hsap V-AHGRLKSRNCIVDGRFVLKITDHGHGRLLEAQKVL----------------------- T01A4.1_Cele IRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEIN--------------LE------- Npr1_Spur IQTHGNLKSSNCVVDSRFVLKITDFGLTSFREPDHAFE-------------PD------- Npr2_Spur IMLHSRLSSSNCVVDSRFVLKLTDYGLTKFRDTDS----------------NE------- Gcy3_Spur THSHGNLKSSNLVVDSRWVLKITDFGLHQFRSGSRPP---------------E------- Npr3_Spur IGVHGRLTSSNCVVDGRFVLKITDFGIPSFRNSNK----------------YE------- Npr4_Spur L-YHGKLTSSNCVVDDRWVVKIADYGLTTFRNQEGSQS--------------N------- Gcy1_Spur IKSHGHLKSSNCVVDNRWVLQITDYGLNEFKKGQKQ-D-------------VD------- Gcy2_Spur IRTHGNLKSSNCVVDSRWVLKITDFGLVHFKVGQQPP---------------D------- Npr5_Spur IKNHGVLSSSTCYVDSRWVLKISGFGLLSFNILKEDVM-------------KQ------- AqueK220_Aque A-IHGRLTSNNCVIDQHWNLKLTDYEPIDIHYTKVKRL-------------S-------- AqueK221_Aque L-THGRLSSVTCVIGNLWKLKLTDYGPDALHSMRTGSQ-------------G-------- AqueK222_Aque IV-HHRLMSTNCVIDDRWVVKITDYGIPSLRVCDSDRA-------------S-------- * * : :: . HSER_Hsap --------------------KKDLWTAPEHLRQAN------------------------- CG10738_Dmel ----------M--QHMSAKCLKLLYRAPELLRQGPS---SL------------------V CG9783_Dmel ----------P----RTRSAKELLWTAPELLRNMK----LH---------QHHHQHGRIQ Gyc32E_Dmel ----------K----SELELKRALCMAPELLRDAY----RP------------------G Gyc76C_Dmel -------------GE-HQHYRNQLWRAPELLRNH-------------------------I CG4224_Dmel ----------GGNCNSHAYWSKLLWTAPELLRVEHN---RP------------------P CG3216_Dmel --------------RDQNYYLKLLWIAPELLPLTT----IP---------GC-------C KSGC_Mmus ----------N---QEATDHSELYWTAPELLRLRE----SP------------------C HSER_Mmus --------------------KKDLWTAPEHLRQAT------------------------- CYGX_Mmus ----------R----PQPAPEELLWTAPELLRGPG------------------------- CYGF_Mmus ----------E----EEPSEEELLWTAPELLRAPG----G------------------IR CYGD_Mmus ----------P----EPPSAEDQLWTAPELLRDPS----L------------------ER ANPb_Mmus ----------D----SHALYAKKLWTAPELLSGNP----LP------------------T ANPa_Mmus ----------Q----GHTLFAKKLWTAPELLRMAS----PP------------------A odr-1_Cele ----------Q--AAHMITYPQYVCFPPEHIREYDD---SGK------QPPR------VV gcy-9_Cele ----------D--PTKDFARKKYLQQAPEIIREIVT---T----------KT------IP gcy-8_Cele ----------D--KSQATQATSILYESPEMLKNREK---NRVRRVDQDWMRQ------TQ gcy-7_Cele ----------------MYEKKDLLWSAPELLRAED----I-------------------- gcy-6_Cele ----------------QYNKSDRLWTSPELLRTDD----I-------------------- gcy-5_Cele ----------------TPSKKRLLWAAPEVLRGSL----TI------------------H gcy-4_Cele ---------------EKPFKKNMLWAAPEVIRGSL----SI------------------E gcy-3_Cele ----------------TPTKRRLLWAAPEVLRGSL----TV------------------S gcy-27_Cele ----------R--SDYTISYAQYVCFPPEHIREYDA---TGK------LPTR------FV gcy-25_Cele ----------A--FDVDAIHYKYLQLAPEHISAILE---K----------LE------EP gcy-23_Cele ----------D--KSGSAQKTSLLYQPPEMLKNKES---NRTRRMDQSWVKQ------SQ gcy-22_Cele ----------------VKEQRDFLHTAPEHIRDTN----L-------------------- gcy-21_Cele ---------------DVQEGKDQLWTSPELLRWSTG---LS---------QC------GV gcy-20_Cele ----------------NPKKEDLLWASPEYLRNED----Q-------------------- gcy-2_Cele ----------------TPPKKRLLWVAPEVLRGSL----SV------------------S gcy-19_Cele ----------------KPMKRRQLWMAPEVIRGTL----LP------------------H gcy-18_Cele ----------D--KSQASQATSIIYMAPELLKNRET---NKRRGMDQSWVKQ------SM gcy-17_Cele ----------------KLSTENMLWWAPEVLRGLE------------------------- gcy-15_Cele ---------------DVQEGKDQLWTSPELLRWSTG---LS---------QC------GV gcy-14_Cele ----------------NPKKEDLLWTPPENLRNEN----E-------------------- gcy-13_Cele ----------------KRTEDGLLHTAPEVLREGL----T-------------------- gcy-12_Cele ----------------YNIWENFLWTAPEAMTINGS---L----------AI------SN gcy-11_Cele IFSNKYNSKTK--NPIKKFSTDLLWFAPEIIRRYAV---KH---------DL------SK gcy-1_Cele ----------------TPPKKRLLWVAPEVLRGSL----SV------------------S daf-11_Cele --------------TPVIKSEELHYFDPAMKKIWKNYADRNE------RALI------TP C04H5.4_Cele ----------E--AEKQWQKMASLYVPPEIRTANEK---NRLKRMDQKWQGQ------TI CYGF_Hsap ----------E----EESSMEELLWTAPELLRAPR----G------------------SR ANPb_Hsap ----------D----SHALYAKKLWTAPELLSGNP----LP------------------T ANPa_Hsap ----------Q----GHTVYAKKLWTAPELLRMAS----PP------------------V CYGD_Hsap ----------P----EPPRAEDQLWTAPELLRDPA----L------------------ER T01A4.1_Cele ----------E--IGEHAYYKKMLWTAPELLRDSN----AP------------------P Npr1_Spur ----------E--EDSYKYYQRRLWTAPELLRLPE----IP------------------S Npr2_Spur ----------R---QTSKNEQKMLWQAPETLRSAN----Q-------------------- Gcy3_Spur ----------I--G-EHAKYEKLLWRAPELLRDPA----PR------------------P Npr3_Spur -----------------DNNYKLLWRAPERLRDPF----S-------------------- Npr4_Spur ----------A---GGYRSKAMQVYLPPENRSNTY------------------------T Gcy1_Spur ----------L---GDHAKLARQLWTSPEHLRQEGS---MP------------------T Gcy2_Spur ----------M--G-EHAYYQDLLWKAPEVWE---------------------------P Npr5_Spur ----------K---DPEVKFSKMLWTAPEHLRGEM----LP------------------S AqueK220_Aque ---------------KLKTAAKKIY--------------Y------------------LP AqueK221_Aque ---------------K-KSSTQ--Y--------------S------------------YC AqueK222_Aque -------------EEGERRKRCLVFFPPEERDST-Y-----------------------Y HSER_Hsap -ISQKGDVYSYGIIAQEIILRKE--TFYTLS--C--------------RD--RNE----- CG10738_Dmel MGTQRGDAYSFGILLYEMHVRRG--PFGETG-----------------LT--PMQ----- CG9783_Dmel LGTQLGDVYSFGIIMQEVVVRGE--PYCMLS-----------------LS--PEE----- Gyc32E_Dmel RGSQKGDVYSFGILLYEMIGRKG--PWGDTA-----------------YS--KEE----- Gyc76C_Dmel HGSQKGDVYAFAIIMYEIFSRKG--PFGQIN-----------------FE--PKE----- CG4224_Dmel EGTQKGDVYAFGIIVHEITTRQG--PFYLGRCAYE-------------KS--PQE----- CG3216_Dmel PATQRGDVYSFGIILEEIVNRGG--PYQEAR--QQ-------------MD--VHT----- KSGC_Mmus SGTPQGDVYSFAILLRDLIHQQAHGPFEDLE-----------------AA--PEE----- HSER_Mmus -ISQKGDVYSFAIIAQEIILRKE--TFYTLS--C--------------RD--HNE----- CYGX_Mmus KATFKGDVFSLAIILQEVLTRDP--PYCSWG-----------------LS--AEE----- CYGF_Mmus LGSFAGDVYSFAIIMQEVMVRGA--PFCMMD-----------------LP--AKE----- CYGD_Mmus RGTLAGDVFSLAIIMQEVVCRST--PYAMLE-----------------LT--PEE----- ANPb_Mmus TGMQKADVYSFAIILQEIALRSG--PFYLEG--LD-------------LS--PKE----- ANPa_Mmus RGSQAGDVYSFGIILQEIALRSG--VFYVEG--LD-------------LS--PKE----- odr-1_Cele RGSPKGDIYCVGMIFYMMVERED--PYHLIH--S---------------V--ERP----N gcy-9_Cele EGSQSADIYALGMVLYQILFRVE--PFHERN--K---------------S--INK----L gcy-8_Cele TRRQLGDVYAFGLVMYEIIFRAL--PFPEG---T---------------N--QSE----- gcy-7_Cele KGSKEGDVYSLGIICAELITRKG--VFNMED--RK-------------ED--PEE----- gcy-6_Cele LGSREGDIYSFGIISAELITRSS--VFDLEN--RK-------------ED--AEE----- gcy-5_Cele QMDPSADVYSFAIIASEILTKRE--AWDISN--RK-------------EG--ADE----- gcy-4_Cele QMDSSADIYSFAIVASEILTKRE--AWDLSR--R------------------KEE----- gcy-3_Cele QMDPSADVFSFAIIASEILTRKE--AWDLKE--RK-------------EG--YDE----- gcy-27_Cele RGSKQGDIYCVGMIFYMMIERED--PYRLIH--S---------------V--ERP----G gcy-25_Cele RGTVEGDIYQLAMCIYQILFYMR--PFAERQ--ES-------------IKVYSGEIFLKL gcy-23_Cele ARRQMGDIYAFGMVMHEILFRAL--PFPNG---T---------------N--VSE----- gcy-22_Cele PITKEMDIYSFAIICSELITKKS--AWDLEN--ET-------------FD--IEE----- gcy-21_Cele LLVQKSDVYSLAIVLYELFGRLG--PWGDEP--M---------------E--PRE----- gcy-20_Cele ERLPEGDIYSFGIICAEILTRSS--AFDLEN--RK-------------EK--PDV----- gcy-2_Cele QMEPSADIYSFAIIASEILTKKE--AWDILD--RK-------------E----------- gcy-19_Cele QIEKSADIYSLAVIASEVLTRKE--AWNMAE--RK-------------DT--VDE----- gcy-18_Cele LRRQAGDIYSFGMVMYEILFRSL--PFRDN---T---------------N--ISE----- gcy-17_Cele QRSKEADIYSFGIICSEVITRSS--AFDLEN--RK-------------EK--PEE----- gcy-15_Cele LLVQKSDVYSLAIVLYELFGRLG--PWGDEP--M---------------E--PRE----- gcy-14_Cele ERLPEGDIYSFGIICSEILTRSS--AFDLEN--RK-------------EK--PDV----- gcy-13_Cele SGTQAGDVYSFSIVCSELVGHSS--AWNLEN--RK-------------EE--ADE----- gcy-12_Cele PPTPKADAYSFGIIFHEIFTREG--PYKIYV--QRGDVNGEAAPKKDSVE--CRA----- gcy-11_Cele LELAKADIYSLAIVLYEIYGRQG--PFGDDL--L---------------D--SDE----- gcy-1_Cele QMEPSADIYSFAIIASEILTKKE--AWDILD--RK-------------ED--CEE----- daf-11_Cele QFGKKCDMYSFGVILHEIILKKK--FVEQLF--D---------------S--PRE---ED C04H5.4_Cele LKRQQSDIYAFGVIIYEILFRSL--PYDEK---V---------------D--LTE----- CYGF_Hsap LGSFAGDVYSFAIIMQEVMVRGT--PFCMMD-----------------LP--AQE----- ANPb_Hsap TGMQKADVYSFGIILQEIALRSG--PFYLEG--LD-------------LS--PKE----- ANPa_Hsap RGSQAGDVYSFGIILQEIALRSG--VFHVEG--LD-------------LS--PKE----- CYGD_Hsap RGTLAGDVFSLAIIMQEVVCRSA--PYAMLE-----------------LT--PEE----- T01A4.1_Cele MGTQKGDIYSFAIILHEMMFRKG--VFALEN--ED-------------LS--PNE----- Npr1_Spur GGTQKGDVYSFGIILQEIMYREG--VFYIKD--VD-------------LM--PEE----- Npr2_Spur QPTQKGDIYSVGIIMQEIVTRAR--PFEEER--SS-------------ME--IDE----- Gcy3_Spur EGTQKGDMYSLGIILYEMATRQG--PYGKCV-----------------LG--PKE----- Npr3_Spur PPSKEGDLYALGIIMLEIGTRCG--PFDEER--KV-------------MD--TNG----- Npr4_Spur LVTQATDVYSYGVILVEIASRNE--VIPEDD--YP-----------------LD------ Gcy1_Spur AGSPQGDIYSFAIILTELYSRQE--PFHENE-----------------MD--LAD----- Gcy2_Spur QGTQKGDVYSFGIILYEIAHRQG--PFGNCE-----------------LS--PKE----- Npr5_Spur KGSQKGDVYSFAIILQEIVTRSH--PFYLSG-----------------YT--SRE----- AqueK220_Aque DQDTVSDIYNFGVILTELCCRET--LLKFGS--I---------------N--FGK----- AqueK221_Aque SQDVSDDIYNFGLVLKEMSSRQY--IIKDKV--A---------------T--IDE----- AqueK222_Aque IPTLSGNVYSFSIILLETATRID--PYSEEL-----------------F----------- : : .: HSER_Hsap ---KIFRV-ENS---NGMKPF--RPDLFLET----A---------EEKELEVYLLVKNCW CG10738_Dmel ---CLQKV-LQPQ--DYLNPY--RPSLQPLE---------T------AFDCVSECLRECW CG9783_Dmel ---IIVKI-KKP-----PPLI--RPSVSKG----------------AAPPEAINIMRQCW Gyc32E_Dmel ---IIQFV-KCPE-MLQHGVF--RPALTHTH----L----D------IPDYIRKCLCQCW Gyc76C_Dmel ---IVDYV-KKLP-LKGEDPF--RPEVESII----E----A----ESCPDYVLACIRDCW CG4224_Dmel ---IIELV-KGYNPHRMQKPF--RPELEPN---------------GDTKADINGIIRRCW CG3216_Dmel ---ILHKV-RQ------CNGF--RPLIRER----------------ECPPDLLELMEKCW KSGC_Mmus ---IISRI-KDP---RAPVPL--RPSLLED----------------KGDGRIVALVRECW HSER_Mmus ---KIFRV-EN----SYGKPF--RPDLFLET----A---------DEKELEVYLLVKSCW CYGX_Mmus ---IIRKV-ASP-----PPLC--RPLVSPD----------------QGPLECIQLMQLCW CYGF_Mmus ---IIDRL-KMP-----PPVY--RPVVSPE----------------YAPAECLQLMKQCW CYGD_Mmus ---VIQRV-RSP-----PPLC--RPLVSMD----------------QAPMECIQLMTQCW ANPb_Mmus ---IVQKV-RNG----QRPYF--RPSIDRT----------------QLNEELVLLMERCW ANPa_Mmus ---IIERV-TRG----EQPPF--RPSMDLQ----------------SHLEELGQLMQRCW odr-1_Cele AT-LIKQI-LNE-------NH--MPRITDD---------------YRQENMLLEMCKECW gcy-9_Cele ME-TLAMA-NDD-----DQLI--RPTFPSSN----T----G----EGYNLQLLSCIEACW gcy-8_Cele ---LVEWL-RDG-----SKVV--KPTIPQN---------------KVLNMDLSALIQDCW gcy-7_Cele ---IIYLL-KKG----GLKSP--RPDLEYDH----T---------IEINPALLHLVRDCF gcy-6_Cele ---IIYML-KKG----GLQSP--RPSLEHDE----S---------IEINPALLHLVRDCW gcy-5_Cele ---ILYMV-KKG----GNRTI--RPELILD---------------AEVSPRLTTLVKDCW gcy-4_Cele ---IKYAV-KKG----GQFVL--RPDLHID---------------IEVNQTLLALVKDCW gcy-3_Cele ---IIYRV-KKG----GSFPI--RPDIITDV--------------PDVNPTLIALVKDCW gcy-27_Cele SG-LMMEI-LDH-------NL--MPFISNN---------------ETQEDTLLDKCKECW gcy-25_Cele PE-LAHLL-SSQ----STAPL--HPKVPEG---------------NSFTMRLLSIIQQCW gcy-23_Cele ---VMDYI-RDG-----TKTF--RPTVHDR---------------TQIHPDLVALLLDCW gcy-22_Cele ---LVYKI-KKG----GRSPP--RPSLETED---------------EHNGSMSLLVRDCW gcy-21_Cele ---IVSLV-KREA-LAGKKPF--RPDMAVLK---------------ESPRIVQETVVAAW gcy-20_Cele ---IIYQV-KKG----GHNPT--RPSLDTGE----T---------VVINPALLHLVRDCW gcy-2_Cele -----------------------------------------------DCEALIALVKDCW gcy-19_Cele ---IVYRI-KKG----GPNAP--RPELDMDG--------------VEINHNLLILIRDCW gcy-18_Cele ---LVDYL-ADG-----SKTV--SPEIQNQ---------------MGLHPDLNALLRDCW gcy-17_Cele ---IIYQL-KKG----GFNAI--RPSLLTDE----A---------LEINPALVHLIRDCW gcy-15_Cele ---IVSLV-KREA-LAGKKPF--RPDMAVLK---------------ESPRIVQETVVAAW gcy-14_Cele ---IIYQV-KKG----GHNPM--RPSLDTGE----T---------VEINPALLHLIRDCW gcy-13_Cele ---IIFMV-KRG----GRTPF--RPSLDDVD--------------DDINPAMLHLIRDCW gcy-12_Cele ---LVEKTVRRV---YSDPYF--RPDTSD-L---------------EVQNYVKEVMAACW gcy-11_Cele ---IIEQL-KFP---DGGALT--RPDIHLIT---------------KAPYPLASVVEKCW gcy-1_Cele ---IVYNV-KKG----GLFPI--RPEIITDI--------------HDVNPALIALVKDCW daf-11_Cele DSVLIDDE-NDA-----IASRFPLPIIIP------E----G----IEMHNDLIKMLENCF C04H5.4_Cele ---LAQKA-AEG-----DKIQ--KPSIQRN---------------KKLNPDLIALLQDCW CYGF_Hsap ---IINRL-KKP-----PPVY--RPVVPPE----------------HAPPECLQLMKQCW ANPb_Hsap ---IVQKV-RNG----QRPYF--RPSIDRT----------------QLNEELVLLMERCW ANPa_Hsap ---IIERV-TRG----EQPPF--RPSLALQ----------------SHLEELGLLMQRCW CYGD_Hsap ---VVQRV-RSP-----PPLC--RPLVSMD----------------QAPVECILLMKQCW T01A4.1_Cele ---IVQRV-RKPV-SEDQEPL--RPWVSETGEGEGD---------DALNDTLLSLMVACW Npr1_Spur ---IVKKV-ANG----YKPAF--RPTIDRV----------------TCSQEMMTLITNCW Npr2_Spur ---IVKKL-TE----TSSPPF--RPEIDPQ----------------LCTDEIRSIIQACW Gcy3_Spur ---IVDKV-THPL--DPNTPF--RPNVMEVD---------D------CPNCMLTGMQECW Npr3_Spur ---ILEIL-KST---SSQPPF--RPSVPEA----------------VWNPVIKDLMKRCW Npr4_Spur -E-------------A-WRPP--LPDLEIGD----TTDDER----CPCPADYLSLIERCW Gcy1_Spur ---IIARV-KIG----EVPPY--RPILNAVN----A----A------APDCVLSAIRACW Gcy2_Spur ---IYEKV-KTL---GETIPL--RPNVMEIE---------N------GHECLLTVMQECW Npr5_Spur ---IIRRV-IRR----DEPPC--RPKINEDE----F----ETSDMATIFTAIYELMKVCW AqueK220_Aque ---I-----------------------HYD---------------EDVGDRYVELIEKCH AqueK221_Aque ---L-----------------------EYD---------------IEVPFEIKKLIESCI AqueK222_Aque -----I----DT---TTGRPR--LPDLAQ------E----G----CPCPSTYQELIESCW . HSER_Hsap EEDPEKRPDFKKIETTLAKIFGLFHDQK--NESYMDTLIRRLQLYSRNLEHLVEERTQLY CG10738_Dmel AERPEDRPDFKTIRTKLRPL----RKGMR--PNIFDNMMAMMEKYANNLEALVDDRTDQL CG9783_Dmel AEQPDMRPDFNSVYERFKML----NHGR--KVNFVDTMFQMLEKYSNNLEELIRERTEQL Gyc32E_Dmel DEDPEVRPDIRLVRMHLKEL----QAGLK--PNIFDNMLSIMEKYAYNLEGLVQERTNLL Gyc76C_Dmel AEDPEERPEFSVIRNRLKKM----RGGKT--KNIMDQMMEMMEKYANNLEDIVTERTRLL CG4224_Dmel AEDPAERPDFNTLKSMIRRF----NKDNE-TGNIVDNLLKRMELYANNLEELVEERTQDY CG3216_Dmel ADNQEERPTFSTIRSNIRTI----MKG-F-CENLMDDLLNRMEQYANNLESLVEEKTRQL KSGC_Mmus DESPELRPIFPSIKKTLREA----SPRG--HVSILDSMMGKLETYANHLEEVVEERTREL HSER_Mmus EEDPEKRPDFKKIESTLAKIFGLFHDQK--NESYMDTLIRRLQLYSRNLEHLVEERTQLY CYGX_Mmus EEAPDDRPSLDQIYTQFKSI----NQGK--KTSVVDSMLRMLEKYSESLEDLVQERTEEL CYGF_Mmus AEASEQRPTFDEIFNQFKTF----NKGK--KTNIIDSMLRMLEQYSSNLEDLIRERTEEL CYGD_Mmus AEHPELRPSMDLTFDLFKSI----NKGR--KTNIIDSMLRMLEQYSSNLEDLIRERTEEL ANPb_Mmus AQDPTERPDFGQIKGFIRRF----NKEG--GTSILDNLLLRMEQYANNLEKLVEERTQAY ANPa_Mmus AEDPQERPPFQQIRLALRKF----NKEN--SSNILDNLLSRMEQYANNLEELVEERTQAY odr-1_Cele DRNPDKRPTIKKLIESIST----VYPLS--KGNLVDQMIRMSEKYADELEQMVAIRTADL gcy-9_Cele LEIPEMRPPIKKVRTMVNAN---LKSTG--KGSLVDQMMKMMEEYTANLENMVRDRTALL gcy-8_Cele NTTPEMRPSLRRIKLNVET----YL-NI--KGSLVDQMTRMMEQYANNLEKLVAERTGML gcy-7_Cele TERPSERPSIETVRSQLRGM----NSSR--NDNLMDHVFNMLESYASSLEEEVSERTKEL gcy-6_Cele TERPSERPDIKQVASQLRSM----NTNR--NDNLMDHVFNVLESYASTLEDEVAERMKEL gcy-5_Cele SEQPEDRPKAEQICKLLSEM----TPRG--NTNLMDHVFNMLEEYTSTLEVDIEERTKEL gcy-4_Cele CENPEERPSAENVCKVLFDM----TPNT--EDNLMDHVFSMLEEYTSSLEVEVGERTKEL gcy-3_Cele AEAPEDRPTAENICEQLRDL----MPKT--KSNLMDHVFNMLEEYTSTLEVEVEERTKEL gcy-27_Cele NRDPEKRPTIENLRNAIAI----CYADS--KGNLIDQMIRMNEKYADELETLVAARSADL gcy-25_Cele LYKPAARPALIKITDAVNR---EFGQDV--KGTLIDQMIEMIDEYSANLEQIVAERTREL gcy-23_Cele NENPEVRPSIRRVRLNTEN----YL-KV--KGSLVDQMMRMMEQYANNLEKLVAERTGML gcy-22_Cele NENPDQRPTSEQIKTLMKSM----NHNR--SSNLMDHVFNVLEQYASNLEDEVQARMKEL gcy-21_Cele TEDPLNRPSLHQIKRKLKPLT----IGL--KRTIMDNMVSMIEKYTDKLEKDIAERNEEL gcy-20_Cele TERPSERPSIEQVRSHLNGM----KDGR--KTNLMDHVFNMLETYASTLEEEVSDRTKEL gcy-2_Cele AEVPEDRPTAENICSQMKGL----VSKQ--KTNLMDHVFNMLEEYTSTLEEEIEERTKEL gcy-19_Cele SEEPADRPSADVICNLLKNM----MP-K--KGNLMDHVFNILEDYTTNLEVEVEDRTKEL gcy-18_Cele SENPEIRPSIRRVRLNTEM----VL-KT--KGSLVDQMMKMMEQYANNLEKLVAERTGML gcy-17_Cele TEKPSERPPIDQVRSLLRGM----NDGK--KGNLMDHVFNMLETYASTLEEEVNERTKEL gcy-15_Cele TEDPLNRPSLHQIKRKLKPLT----IGL--KRTIMDNMVSMIEKYTDKLEKDIAERNEEL gcy-14_Cele TERPSERPSIEQVRGHLNGM----RDGR--KSNLMDHVFNMLETYASTLEEEVSDRTKEL gcy-13_Cele DEDPKQRPNIDMVNKLMKNM----NSGRSGSANLMDHVFSVLEKHASSLEDEVQERMKEL gcy-12_Cele HHDPYQRPEFKTIKNKLKPLF---HQIY--KQNIMDHMVLMMEKYQTQLEDLVDERTIEL gcy-11_Cele VEDPASRPSIQKVRELLEPLS----KGL--KGNIADNIMNLLDRYRNNLEDVIKERTEQL gcy-1_Cele AEVPEDRPTAENICSQMKGL----VSKQ--KTNLMDHVFNMLEEYTSTLEEEIEERTKEL daf-11_Cele GS---VRPDIALARKIIDT----VLK-M--SGSLVDLMIKNLTAYTQGLNETVKNRTAEL C04H5.4_Cele SDQPDMRPTIRRVRLATEI----AL-KT--KGNLVDSMMRMMEEYANNLEKLVGERTKLA CYGF_Hsap AEAAEQRPTFDEIFNQFKTF----NKGK--KTNIIDSMLRMLEQYSSNLEDLIRERTEEL ANPb_Hsap AQDPAERPDFGQIKGFIRRF----NKEG--GTSILDNLLLRMEQYANNLEKLVEERTQAY ANPa_Hsap AEDPQERPPFQQIRLTLRKF----NREN--SSNILDNLLSRMEQYANNLEELVEERTQAY CYGD_Hsap AEQPELRPSMDHTFDLFKNI----NKGR--KTNIIDSMLRMLEQYSSNLEDLIRERTEEL T01A4.1_Cele SEDPHERPEVSSVRKAVRSL----NRDNE-TSNLVDNLLKRMEQYANNLEGLVEERTQEY Npr1_Spur KEDSTIRPDYSQLRGTMRKL----NKNSE-NKGLVDTLLSRMEQYASNLESLVQERTEAF Npr2_Spur EEMPENRPATTDLLSSMKKI----NKNLS-GGNILDNLLSRMEQYATNLETLVEERTAAF Gcy3_Spur NENPDERPEVKTLTTRLKPL----QKGMK--PNILDNMIVIMEKYANNLEDIVEDRTHQL Npr3_Spur AENPGDRPTASALQTALKKI----NKGTSSGGNILDNLLNRMEQYATNLESLVEERTAAF Npr4_Spur NINPAQRPHFSQIRQTLHSI----NPS-K--LSPVDLMMQLMEKYSRHLESIVAERTQDL Gcy1_Spur PEDPDDRPNIMAVRTMLAPL----QKGLK--PNILDNMIAIMERYTNNLEELVDERTQEL Gcy2_Spur VEDPEARPDFKTIANKLKPL----HKGMK--SDILDNMVMIMEKYANNLEEIVEDRTQQL Npr5_Spur EELPEDRPDFTAIRAKLRGL----QKGRK-ELDILDNMLSKMEKYTENLEKVVADRTGQL AqueK220_Aque QMKKSARPSASFIKGYLKDC----LSF-Y--TFHFKNDTAAAEMYSKNLERHILELNTSI AqueK221_Aque SNNLLQRPTTERIKTCLKRS----VA--K--CGLSQDVTGVAEVNLRNLENNIEVLKMNV AqueK222_Aque DEVPGNRPSFDQIKKSILRM----NPN-K--ESPVDTMMKMMEKYSKHLEALVGERTQEL ** . *: : HSER_Hsap KAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEV- CG10738_Dmel QEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQV- CG9783_Dmel DIERKKTEQLLNRMLPSSVAEKLKMGLAVDPEEFSDVTIYFSDIVGFTTIAAHCSPVQV- Gyc32E_Dmel YEEKKKTDMLLYQMLPRPVAELLKRGDPVEAECFDCVTILFSDIVGFTELCTTSTPFEV- Gyc76C_Dmel CEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQV- CG4224_Dmel HEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQV- CG3216_Dmel SLEKQRTEELLYQILPRPVAQQLMAGDLVEPEEFSSVTIYFSDIVGFTELCARSSPMDV- KSGC_Mmus VAEKRKVEKLLSTMLPSFVGEQLIAGKSVEPEHFESVTIFFSDIVGFTKLCSLSSPLQV- HSER_Mmus KAERDRADHLNFMLLPRLVVKSLKEKGIVEPELYEEVTIYFSDIVGFTTICKYSTPMEV- CYGX_Mmus ELERRKTERLLSQMLPPSVAHALKMGTTVEPEYFDQVTIYFSDIVGFTTISALSEPIEV- CYGF_Mmus EIEKQKTEKLLTQMLPLSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEV- CYGD_Mmus EQEKQKTDRLLTQMLPPSVAEALKMGTSVEPEYFEEVTLYFSDIVGFTTISAMSEPIEV- ANPb_Mmus LEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQV- ANPa_Mmus LEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQV- odr-1_Cele ADAQMQTMRLLNEMLPASIAKDLKNGLIMPPRSYESATVMFVQICDFNALMKRSSPEQV- gcy-9_Cele EEAQKQADRLLNSMLPKSIAEDLKIGKPVLPQLYSCATVLFSDIRGFTRISSTSTPLQVC gcy-8_Cele EEANQRADRLLSQLLPAYVANELKLGRPVPPKTFTSSTVLFSDIVGFTEMCQNASPLEV- gcy-7_Cele VEEKKKSDVLLYRMLPKTVADKLKLGQTVEPETFEQVTIFFSDVVQFTTLASKCTPLQV- gcy-6_Cele VEEKKKSDVLLYRMLPRQVADKLKLGQTVEPETFDIVTLFFSDVVSFTTLAGKCTPLQV- gcy-5_Cele TLEKKKADILLSRMLPKQVAERLKAGQTVEPEGFDTVTVLFSDVVKFTQLAAKCSPFQV- gcy-4_Cele TLEKKKSDILLGRMLPKQVAERLKAGQAVEPESFDLVTVFFSDLVKFTDLASKCSPFQV- gcy-3_Cele TLEKKKADLLLSRMLPKQVAERLKAGQTVEPEGFDSVTVFFSDVVKFTILASKCTPFQV- gcy-27_Cele ALAQMQTMRLLNEMLPASIAKDLKNGVIAPARSYASATVMFVQICDFIVILKRRPPKEV- gcy-25_Cele EQDMSVTENLLYQLLPKSVADSIRSGKTVVPEQHSSVTLLVVDVCQFTKFCEAFIPVHI- gcy-23_Cele EEANVRADKLLGQLLPKYVANELKMGRSVPAKTFDMATVMFSDIVGFTTICSSSTPLEV- gcy-22_Cele TEEKKRSDVLLYRMLPKQVAEKLKLGQSVEPETFDCVTIFFSDVVSFTTLASRCTPLQV- gcy-21_Cele EGEKAKSEALLKMMLPEVVADSLKLGSNVSAESFENCTVFFSDCPGFVEMSATSKPIDI- gcy-20_Cele TEEKKKSDVLLYRMLPRMVADKLKLGQTVEPETFEQVTIFFSDVVQFTTLAGKCTPLQV- gcy-2_Cele TLEKKKADILLSRMLPKQVAERLKAGQTVEPEGFDSVTVFFSDVVKFTILASKCSPFQT- gcy-19_Cele TAEKKKADVLLGRMLPKQVAERLKQGQTVEPEGFDSVTVFFSDVVKFTQLAAKCSPFQV- gcy-18_Cele EEANIRADQLLTQLLPAYVANELKMGRSVAPKLYSSATILFSDIVGFTTICSGSTPLEV- gcy-17_Cele VEEQKKSDVLLYRMLPKTVAEKLKAGISIEPETFELVTIFFSDVVQFTTLASKCTPLQV- gcy-15_Cele EAEKAKSEALLKMMLPEVVADSLKLGSNVSAESFENCTVFFSDCPGFVEMSATSKPIDI- gcy-14_Cele VEEKKKSDVLLYRMLPKMVADKLKLGQTVEPETFEQVTIFFSDVVQFTTLAGKCTPLQV- gcy-13_Cele VEEKKKSDILLYRMLPQQVAERLKLGQSVEPEAFESVTIFFSDVVGFT----------V- gcy-12_Cele KDEQRRSQHLLQRMLPSSVAEQLLAGQDVIPEAFPPVTIYFSDIVGFTTISGESTPMEV- gcy-11_Cele EDERKRNESLLLQLLPKSVANSLKNGQPVDAEFYDSVSIYFSDIVGFTALSSKSTPLQV- gcy-1_Cele TLEKKKADILLSRMLPKQVAERLKAGQTVEPEGFDSVTVFFSDVVKFTILASKCSPFQT- daf-11_Cele EKEQEKGDQLLMELLPKSVANDLKNGIAVDPKVYENATILYSDIVGFTSLCSQSQPMEV- C04H5.4_Cele EEANLRAERLLFQLLPKHVAIELKAGRTVAPKMYDSATVMFSDIVGFTKLCSASTPIEV- CYGF_Hsap EIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEV- ANPb_Hsap LEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQV- ANPa_Hsap LEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQV- CYGD_Hsap ELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEV- T01A4.1_Cele LAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQV- Npr1_Spur YEEKRKAEELLYQILPRPVAEELKKGKPVTAESFECVTIYFSDIVGFTKLSSASTPLEV- Npr2_Spur LEEKKRSETLLYEVLPRSVAEQLKQGSSVSPKSYESVTIYFSDIVGFTSISADSTPLQV- Gcy3_Spur IEEKKKTDNLLHQMLPKPVANQLKRGMQVVPESFECVTIFFSDIVGFTSLSSESTPFEV- Npr3_Spur LEEKKRSETLLYEVLPRSVAEQLKQGKSVDPESYENVTIFFSDIVGFTSLSSQSTPLEV- Npr4_Spur LLEKQKTDRLLYSMLPQPVADDLRQGNIAKAEQYESCSIFFSDIVGFTSLSSTSSPYEV- Gcy1_Spur QKEKTKTEQLLHRMLPPSIASQLIKGIAVLPETFEMVSIFFSDIVGFTALSAASTPIQV- Gcy2_Spur VEEKKKTENLLHRMLPKPVANQLKRGMQVVPESFDCVTIFFSDIVGFTKLSSMSTPFQV- Npr5_Spur LEEKKKTDALLFRMLPEVVAEELKKGNQFPGEFFDHVTVYFSDVVGFTDISAQSTPMQV- AqueK220_Aque QDEKNANGDILANHIPKPAINAIQNKIPLKMKLAPNTVILCFGLCDIDGILSTYTKEQV- AqueK221_Aque SIQKQDNDLILEKCMPSEVVKSIRDKSIKPLENYDDVIIVC---VTLVDIDKDYSVSEI- AqueK222_Aque IIEQKKTQQLLYTMLPQAVADELRQGRPASAKQYSSVTIYFSDIVGFTTLAGASSPMEV- : :* : : : HSER_Hsap --------VDMLNDIYKSFDHIVDHHDVYKV------ETIGDAYMVASGLPKRN-GN-RH CG10738_Dmel --------VDFLNDLYTCFDSIIGHYDVYKV------ETIGDAYMVVSGLPLRN-GD-LH CG9783_Dmel --------VDLLNDLYTIFDATINAYNVYKV------ETIGDAYMVVSGLPVKI--P-DH Gyc32E_Dmel --------VEMLNDWYTCCDSIISNYDVYKV------ETIGDAYMVVSGLPLQN-GS-RH Gyc76C_Dmel --------VNFLNDLYTVFDRIIRGYDVYKV------ETIGDAYMVVSGLPIKN-GD-RH CG4224_Dmel --------VQFLNDLYTCFDSIVENFDVYKV------ETIGDAYMVVSGLPIRN-GN-QH CG3216_Dmel --------VNFLNDLYSTFDRIIGFYDVYKV------ETIGDAYLVVSGLPEPN-GD-KH KSGC_Mmus --------VKLLNDLYSLFDHTIQSHDVYKV------ETIGDAYMVASGLPIRN-GA-QH HSER_Mmus --------VDMLNDIYKSFDQIVDHHDVYKV------ETIGDAYVVASGLPMRN-GN-RH CYGX_Mmus --------VGFLNDLYTLFDAVLDSHDVYKV------ETIGDAYMVASGLPRRN-GN-RH CYGF_Mmus --------VDLLNDLYTLFDAIIGSHDVYKV------ETIGDAYMVASGLPKRN-GS-RH CYGD_Mmus --------VDLLNDLYTLFDAIIGAHDVYKV------ETIGDAYMVASGLPQRN-GQ-RH ANPb_Mmus --------VTLLNDLYTCFDAIIDNFDVYKV------ETIGDAYMVVSGLPGRN-GQ-RH ANPa_Mmus --------VTLLNDLYTCFDAVIDNFDVYKV------ETIGDAYMVVSGLPVRN-GQ-LH odr-1_Cele --------IAFLNDIYDQFDTVIKRHDAYKV------ETTGETYMVASGVPHEN-EG-RH gcy-9_Cele KLRQKIIVVTFLNDMFSGFDAIIAKHDAYKV------ETIGDAYMIVSGVPTEN-GN-SH gcy-8_Cele --------VAVLNGIFDGFDQFIARKDAYKV------ETIGDAYMVVSGVPEEN-GH-RH gcy-7_Cele --------VNLLNDLYTIFDGIIEKHDVYKV------ETIGDGYLCVSGLPHRN-GN-EH gcy-6_Cele --------VNLLNGLYTIFDGIIEQHDVYKV------ETIGDGYFVASGVPRRN-GN-EH gcy-5_Cele --------VNLLNDLYSNFDTIIEEHGVYKV------ESIGDGYLCVSGLPTKN-GY-AH gcy-4_Cele --------VNLLNDVFSNFDSIIEKHDVYKV------ESIGDGFLCVSGLPNRN-GM-EH gcy-3_Cele --------VNLLNDLYSNFDTIIEEHGVYKV------ESIGDGYLCVSGLPTRN-GF-NH gcy-27_Cele --------IGFLNDIFDQFDTVIKRHD---V------ETTGETYMVASGVPNEN-EG-RH gcy-25_Cele --------LETLQELYSSFDNIVQKNKAFKV------ENVGDAYLICSGIPEMS-GF-RH gcy-23_Cele --------VSMLNSIYSKFDDAINKHGSYKV------ETIGDAYMIVSGIPEEN-GN-EH gcy-22_Cele --------VNLLNDLYTTFDAIIEQHDVYKV------ETIGDGYLCVSGLPHRN-GN-EH gcy-21_Cele --------VQFLNDLYTVFDRIIDQFDVYKV------ETIADAYMVASGLPVPN-GN-HH gcy-20_Cele --------VTLLNDLYTIFDGIIEQNDVYKV------ETIGDGYLCVSGLPHRN-GN-DH gcy-2_Cele --------VNLLNDLYSNFDTIIEQHGVYKV------ESIGDGYLCVSGLPTRN-GY-AH gcy-19_Cele --------VNLLNDLYSNFDAIIEEHGCYKV------ESIGDGYLCVSGLPSKN-GN-AH gcy-18_Cele --------VNMLNGLYTGFDECITRNKSYKV------ETIGDAYMVVSGIPEEN-EY-NH gcy-17_Cele --------VQLLNDLYTIFDSIIEQNDVYKV------ETIGDGYLCVSGLPHRN-GH-DH gcy-15_Cele --------VQFLNDLYTVFDRIIDQFDVYKV------ETIADAYMVASGLPVPN-GN-HH gcy-14_Cele --------VTLLNDLYTIFDGIIEQNDVYKV------ETIGDGYLCVSGLPHRN-GN-EH gcy-13_Cele --------VNLLNDLYTTFDAIIEKNDSYKV------ETIGDAYLVVSGLPRRN-GT-EH gcy-12_Cele --------VTFLNKLYTLFDSIIRRYDVYKV------ETIGDAYMVVSGVPQYKTME-YH gcy-11_Cele --------VNMLNNLYTNFDTIIDKFDCYKV------ETIGDAYMFVSGLPEVN-SY-LH gcy-1_Cele --------VNLLNDLYSNFDTIIEQHGVYKV------ESIGDGYLCVSGLPTRN-GY-AH daf-11_Cele --------VTLLSGMYQRFDLIISQQGGYKVILNRIMETIGDAYCVAAGLPVVM-EK-DH C04H5.4_Cele --------VNLLNKLYSEFDTVISKHDCYKV------ETIGDAYMVVSGIPIEN-GQ-RH CYGF_Hsap --------VDLLNDLYTLFDAIIGSHDVYKV------ETIGDAYMVASGLPKRN-GS-RH ANPb_Hsap --------VTLLNDLYTCFDAIIDNFDVYKV------ETIGDAYMVVSGLPGRN-GQ-RH ANPa_Hsap --------VTLLNDLYTCFDAVIDNFDVYKV------ETIGDAYMVVSGLPVRN-GR-LH CYGD_Hsap --------VDLLNDLYTLFDAIIGSHDVYKV------ETIGDAYMVASGLPQRN-GQ-RH T01A4.1_Cele --------VTLLNDLYLAFDGVVDNFKVYKV------ETIGDAYMVVSGLPERR--D-DH Npr1_Spur --------VDLLNDLYTCFDAVIDNFNVYKV------ETIGDAYMCVSGLPIRN-GD-FH Npr2_Spur --------VTLLNDLYTCFDGTIGNFDVYKV------ETIGDAYMVVSGLPIRN-GI-HH Gcy3_Spur --------VDMLNDLYTLFDEIISYYDVYKV------ETIGDAYMLVSGLPLRN-EK-KH Npr3_Spur --------VALLNDLYTCFDSIIANFDVYKV------ETIGDAYMVVSGLPIRN-GF-AH Npr4_Spur --------VALLNKLYVTFDSIIDNYDVYKV----------------------------- Gcy1_Spur --------VNLLNDLYTLFDAIISNYDVYKV------ETIGDAYMLVSGLPLRN-GD-RH Gcy2_Spur --------VDLLNDLYTLFDDIISYYNVYKV------ETIGDAYMLVSGLPIRN-DN-RH Npr5_Spur --------VDLLNDLYTCFDAVLERFDVYKV------ETIGDAYMVVSGLPRRN-GN-RH AqueK220_Aque --------SKIIVIVDRLLDGIATSFNMHRI------QSFGSTWTYISYQYEEETADKPG AqueK221_Aque --------PAIIEKADKVLHGAASTAGLIRI------QATGTSWIYASGVYKPEC-E-VT AqueK222_Aque --------VTFLNELYSTFDDILDKFDVYKV------ETIGDAYMVVSGVPRVN-GD-KH : . : HSER_Hsap AIDIAKMALEILSFMGTFEL-EHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVN CG10738_Dmel AAEIATMSLHLLSAVSEFKI-RHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVN CG9783_Dmel AEQIATMALDLLHQSGRFNV-KHLPGVPLQLRIGLHTGPCCAGVVGLTMPRYCLFGDTVN Gyc32E_Dmel AGEIASLALHLLETVGNLKI-RHKPTETVQLRIGVHSGPCAAGVVGQKMPRYCLFGDTVN Gyc76C_Dmel AGEIASMALELLHAVKQHRI-AHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVN CG4224_Dmel AREIARLALALLEAVHNFRI-HHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVN CG3216_Dmel AREIALMALDILRAVSSFNL-RHKPEYKIQIRIGMHSGSVCAGVVGKKMPHYCLFGDTVN KSGC_Mmus ADEIATMALHLLSVTTHFQI-GHMPEERLKLRIGLHTGPVVAGVVGITMPRYCLFGDTVN HSER_Mmus AVDISKMALDILSFIGTFEL-EHLPGLPVWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVN CYGX_Mmus AAEIANLALDILSYAGNFRM-RHAPDVPIRVRAGLHSGPCVAGVVGLTMPRYCLFGDTVN CYGF_Mmus AAEIANMSLDILSSVGTFKM-RHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVN CYGD_Mmus AAEIANMSLDILSAVGSFRM-RHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVN ANPb_Mmus APEIARMALALLDAVSSFRI-RHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVN ANPa_Mmus AREVARMALALLDAVRSFRI-RHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVN odr-1_Cele IFEVAEISLEIREISYIYVL-QHDKNYKLRIRIGFHAGPIAAGVIGIRSPRYCLFGDTVN gcy-9_Cele AQNIADVALKMRAFICNFKL-AHRPEELMMVRIGFHSGPVAAGVVGLAAPRYCLFGDTVN gcy-8_Cele INEIASIALDVHKFLSEFIV-PHKRDTKVQCRLGFHTGPVAAAVVGLNAPRYCLFGDTVN gcy-7_Cele VRQIALMSLAFLSSLQFFRV-PHLPSERINLRIGMNCGSVVAGVVGLTMPRFCLFGDAVN gcy-6_Cele TRNIASMSINFVKSLADFSI-PHLPGEKIKIRVGFHCGSVVAGVVGLTMPRYCLFGDAVN gcy-5_Cele IKQIVDMSLKFMDYCKSFKV-PHLPREKVELRIGINSGPCVAGVVGLSMPRYCLFGDTVN gcy-4_Cele IRQIVGMSLCFMEFCRNFRI-PHLPRERVELRVGINSGPCVAGVVGLSMPRYCLFGDTVN gcy-3_Cele IKQIVDMSLKFMDYCKNFKI-PHLPRERVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVN gcy-27_Cele VFEVAEMSLEIRAISLSYTL-ENDKNYKLRVRIGFHAGPIAAGVIGIKNPRYCLFGDTVN gcy-25_Cele LREICKISLKLQAFMKTFKV-RHRPSHTLQIKMGITSGAVAAGILGSTAPRFCIFGDTVN gcy-23_Cele IRNICNTALELMLLLKTYEI-PHRRNVKLRIRLGIHTGTVAAGVVGLTAPRYCLFGDTVN gcy-22_Cele AKEISSMSFSLLKAIKTFRV-PHLPKERINIRVGLHTGPVVTGVVGMTMPRYCLFGDSVN gcy-21_Cele AGEIASLGLALLKAVESFKI-RHLPNEKVRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVN gcy-20_Cele IRHIARMSLGFLSSLEFFRV-QHLPAERINLRIGINCGSVVAGVVGLTMPRYCLFGDAVN gcy-2_Cele IKQIVDMSLKFMEYCRSFKI-PHLPRENVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVN gcy-19_Cele IKQIVELSLDFMSYCKSFKI-PHLPREKVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVN gcy-18_Cele SRNIANTALDMRQYLTGYQI-PHRPTHRVRCRWGFHTGSVAAGVVGLTCPRYCLFGDTVN gcy-17_Cele IKHIARMSLAFLSSLAEFRV-AHMPS------------SVVAGVVGLTMPRYCLFGDAVN gcy-15_Cele AGEIASLGLALLKAVESFKI-RHLPNEKVRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVN gcy-14_Cele IRHIARMSLGFLSSLEFFRV-QHLPSERINLRIGINCGSVVAGVVGLTMPRYCLFGDAVN gcy-13_Cele VANIANMSLELMDSLQAFKI-PHLPQEKVQIRIGMHSGSCVAGVVGLTMPRYCLFGDTVN gcy-12_Cele AEQIAMMAIHILSAVRSFSI-PHRSCEPLMIRIGMHTGPCVAGVVGKTMPRYTLFGDTVN gcy-11_Cele AGEVASASLELLDSIKTFTV-SHCPDEKLRLRIGNHTGPVVTGVVGIRMPRYCLFGDTVI gcy-1_Cele IKQIVDMSLKFMEYCKSFNI-PHLPRENVELRIGVNSGPCVAGVVGLSMPRYCLFGDTVN daf-11_Cele VKSICMIALLQRDCLHHFEI-PHRPGTFLNCRWGFNSGPVFAGVIGQKAPRYACFGEAVI C04H5.4_Cele VANISAVTLGIMDLLKVFEV-PHRRDYRLTIRLGFASGQVSAAVVGLSSPRYCLFGETVN CYGF_Hsap AAEIANMSLDILSSVGTFKM-RHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVN ANPb_Hsap APEIARMALALLDAVSSFRI-RHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVN ANPa_Hsap ACEVARMALALLDAVRSFRI-RHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVN CYGD_Hsap AAEIANMSLDILSAVGTFRM-RHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVN T01A4.1_Cele ANQIAQMSLSLLHKVKNFVI-RHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVN Npr1_Spur AREIARMSLALLHEITSFRI-RHRPEERLRLRIGVHTGPVVAGVVGLKMPRYCLFGDTVN Npr2_Spur VKEIASMALSLVREAYKFRI-RHKPEEKLLLRVGVHSGACVAGVVGLRMPRYCLFGDTVN Gcy3_Spur AAEIASTSLHLLEDVKAFKV-RHRPEVNLKLRIGIHSGSTVSGVVGLTMPRYCLFGDTVN Npr3_Spur AREIAQMSLALLGAVTSFKI-RHRPDEQLKLRAGIHSGPCVAGVIGVKMPRYCLFGDTVN Npr4_Spur ------------------------------------------------------------ Gcy1_Spur AGQIASTAHHLLESVKGFIV-PHKPEVFLKLRIGIHSGSCVAGVVGLTMPRYCLFGDTVN Gcy2_Spur AAEIGSTALHLIDEVQKFKI-RHRPDDTLKLRVGIHSGPVVTGVVGLTMPRYCLFGDTVN Npr5_Spur AGEIACVALELLTGARQFRI-RHKPDHQLQIRIGINTGPVAAGVVGLTMPRFCLFGDTVN AqueK220_Aque VQEVFNCAVKLLL---LFKE--RQSTQKLSVRMSIHLGDLICGVVNETIPFHAAVGAPID AqueK221_Aque VVE----SLKAVS---LIKSSLEDSQHKIYPKFAIHQDSVTCGVVNQSAPFHVLLGKASA AqueK222_Aque AGEIARMALQLLAASKIFVI-PHKPNTELKIRIGIHSGPVCAGVVGLKMPRYCLFGDTVN HSER_Hsap TASRMESTGL------------------PL--------RIHVSGSTIAILKR-TE----C CG10738_Dmel TASRMESSGV------------------PL--------KIHCSWQCRQLLDR-L-----G CG9783_Dmel TASRMESTGS------------------SW--------RIHMSQETRDRLDA-R-----G Gyc32E_Dmel TASRMESTGD------------------SM--------RIHISEATYQLLQV-I-----G Gyc76C_Dmel TASRMESNGE------------------AL--------KIHISNKCKLALDK-LG----G CG4224_Dmel TASRMESNGE------------------AL--------KIHISETTKEALDE-F-----G CG3216_Dmel TASRMESTGQ------------------PG--------KIHVSSATKAILDK-F-----G KSGC_Mmus MASRMESSSL------------------PL--------RIHVSQSTAGALLA-A-----G HSER_Mmus TASRMESTGL------------------PL--------RIHMSSSTITILKR-TD----C CYGX_Mmus TASRMESTGL------------------PY--------RIHVSQSTVQALLS-LD----E CYGF_Mmus TASRMESTGL------------------PY--------RIHVSLSTVTILQT-LS----E CYGD_Mmus TASRMESTGL------------------PY--------RIHVNMSTVRILRA-LD----Q ANPb_Mmus TASRMESNGQ------------------AL--------KIHVSSTTKDALDE-L-----G ANPa_Mmus TASRMESNGE------------------AL--------RIHLSSETKAVLEE-F-----D odr-1_Cele FASRMQSNCP------------------PN--------QIQTSEITARLLFDS------H gcy-9_Cele TASRMESTGV------------------AN--------KIQISEGAYNLLHCF-F----P gcy-8_Cele MASRMESNSE------------------PG--------KTQISETAKNLLLKE-Y----P gcy-7_Cele TASRMESNGK------------------PG--------KIHVSAEANRMLHL-V-----G gcy-6_Cele TASRMESNSKRKIFQKSTNISSSFHLFSAG--------QIHLSEEANQMLMR-L-----G gcy-5_Cele TASRMESNGK------------------PS--------MIHMSEAAHSLLTDHYP----H gcy-4_Cele TASRMESNGK------------------PS--------MIHMSEAAHSLLVNNYP----Y gcy-3_Cele TASRMESNGK------------------PS--------LIHLTSDAHLLLMKHFP----H gcy-27_Cele FASRMQSNCP------------------PL--------QIQTSEITARMLLAT------H gcy-25_Cele MACRMASTGN------------------PG--------SIQLSELTANTLMEKF-----P gcy-23_Cele VASRMESTSE------------------PE--------KIQMSQEARDFCVRY-Y----S gcy-22_Cele TASRMESNGK------------------PG--------RVHISTECMKFLTEVI-----G gcy-21_Cele TASRMESNGI------------------PL--------RINCSGTAKEILDQ-L-----G gcy-20_Cele TASRMESNGK------------------PG--------QIHVTAEANRMLTQVV-----G gcy-2_Cele TASRMESNGK------------------PS--------LIHLTSDAHLLLLTHYP----N gcy-19_Cele TASRMESNGK------------------GRQMALKSSSHIHLSAASYTLLMKHYP----N gcy-18_Cele VSSRMESTGT------------------PG--------MIQMSEEAHMHIRAH-H----P gcy-17_Cele TASRMESNGK------------------PG--------RIHVSSEANHLLTHVV-----G gcy-15_Cele TASRMESNGIRKFFWVAEPV-------SSL--------RINCSGTAKEILDQ-L-----G gcy-14_Cele TASRMESNGK------------------PG--------KIHVTAEANQMLTQVV-----G gcy-13_Cele TASRMESNGK------------------PG--------FIHLSSDCYDLLTSLY-----K gcy-12_Cele TASRMESNGE------------------AL--------RIHCSSSTQKVLTS-ID----Q gcy-11_Cele IANMMESSGE------------------PM--------RIQISSDAYELILK-C-----G gcy-1_Cele TASRMESNGK------------------PS--------LIHLTNDAHSLLTTHYP----N daf-11_Cele LASKMESSGV------------------ED--------RIQMTLASQQLLEEN-F----P C04H5.4_Cele IAAVMESSGE------------------GG--------RVQITETSKILLENE-Y----P CYGF_Hsap TASRMESTGL------------------PY--------RIHVSLSTVTILQN-LS----E ANPb_Hsap TASRMESNGQ------------------AL--------KIHVSSTTKDALDE-L-----G ANPa_Hsap TASRMESNGE------------------AL--------KIHLSSETKAVLEE-F-----G CYGD_Hsap TASRMESTGL------------------PY--------RIHVNLSTVGILRA-LD----S T01A4.1_Cele TSSRMESNGL------------------RM--------FWNFSLYKIYKFKV-FKNKIEL Npr1_Spur TASRMESNGE------------------AM--------KIHLSNQTKKILEL-F-----G Npr2_Spur TASRMESTGQ------------------AM--------KVHISESTKKLLDT-F-----K Gcy3_Spur TASRMESNGE------------------AL--------KIHTSSETKNLLEQ-M-----G Npr3_Spur TTSRMESTGE------------------AL--------KIHTSLTCKTILDK-F-----Q Npr4_Spur ------------------------------------------------------------ Gcy1_Spur TASRMESNGL------------------AL--------RIHVSPWCKQVLDK-L-----G Gcy2_Spur TSSRMESNGE------------------AL--------KIHCSAECKAILDE-V-----G Npr5_Spur TASRMESNSL------------------PQ--------KIHCSSDSAAVLKE-L-----G AqueK220_Aque DATQLMIQCP------------------VN--------AVLISERAKNDLPNR-M----G AqueK221_Aque SALSILHHCP------------------DN--------GIIVSEPVKLCLSKN------- AqueK222_Aque TASRMESNSE------------------AM--------KIHCSNDTAQLLKK-V-----G HSER_Hsap QFLYEVRGETYLK----------------------------------------------- CG10738_Dmel GYHFAERGVISMK----------------------------------------------- CG9783_Dmel GYAIEPRGLIDIK----------------------------------------------- Gyc32E_Dmel SYVCIERGLTSIK----------------------------------------------- Gyc76C_Dmel GYITEKRGLVNMK----------------------------------------------- CG4224_Dmel TFVTTRRGFVPMK----------------------------------------------- CG3216_Dmel TFQMEQRGDVELK----------------------------------------------- KSGC_Mmus GYHLQKRGTISVK----------------------------------------------- HSER_Mmus QFLYEVRGETYLK----------------------------------------------- CYGX_Mmus GYKIDVRGQTELK----------------------------------------------- CYGF_Mmus GYEVELRGRTELK----------------------------------------------- CYGD_Mmus GFQMECRGRTELK----------------------------------------------- ANPb_Mmus CFQLELRGDVEMK----------------------------------------------- ANPa_Mmus GFELELRGDVEMK----------------------------------------------- odr-1_Cele EYKFVKRGIVHVK----------------------------------------------- gcy-9_Cele QFQMVERGKIEVK----------------------------------------------- gcy-8_Cele DYICEQRGEIPIK----------------------------------------------- gcy-7_Cele GFDTESRGEVIIK----------------------------------------------- gcy-6_Cele GFTTEPRGEVIIK----------------------------------------------- gcy-5_Cele QYETSSRGEVIIK----------------------------------------------- gcy-4_Cele QFETNSRGEVIIK----------------------------------------------- gcy-3_Cele QYETNSRGEVIIK----------------------------------------------- gcy-27_Cele EYKLVKRGIVHVK----------------------------------------------- gcy-25_Cele SFMLEERGMIDVK----------------------------------------------- gcy-23_Cele EFQITLRGTVEAK----------------------------------------------- gcy-22_Cele GYQTEPRGEVIVK----------------------------------------------- gcy-21_Cele GYEIEERGIVEMK----------------------------------------------- gcy-20_Cele GFRTESRGEVIIK----------------------------------------------- gcy-2_Cele HYDTSSRGEVIIK----------------------------------------------- gcy-19_Cele QYNTASRGDVIIK----------------------------------------------- gcy-18_Cele VFTTTERGEVQVK----------------------------------------------- gcy-17_Cele GFRTEERGEVIIK----------------------------------------------- gcy-15_Cele GYEIEERGIVEMK----------------------------------------------- gcy-14_Cele GFRTESRGEVIIK----------------------------------------------- gcy-13_Cele EYNTESRGEVIIK----------------------------------------------- gcy-12_Cele GFLLEERGSLAIK----------------------------------------------- gcy-11_Cele GYVTEQREKIVLK----------------------------------------------- gcy-1_Cele QYETSSRGEVIIK----------------------------------------------- daf-11_Cele QFVCSNRGGRTIE----------------------------------------------- C04H5.4_Cele EFIIEIRGINKDV----------------------------------------------- CYGF_Hsap GYEVELRGRTELK----------------------------------------------- ANPb_Hsap CFQLELRGDVEMK----------------------------------------------- ANPa_Hsap GFELELRGDVEMK----------------------------------------------- CYGD_Hsap GYQVELRGRTELK----------------------------------------------- T01A4.1_Cele DFLKNEKESIEFE----------------------------------------------- Npr1_Spur TFILELRGEVEMK----------------------------------------------- Npr2_Spur NFETEPRGEVVLKAYRVPPCPKMSADGGERRGHTVVRYQSGQHVNRALALIYTRWDPAKV Gcy3_Spur GFVVEERGLISMK----------------------------------------------- Npr3_Spur IFVLELRGLVEMK----------------------------------------------- Npr4_Spur ------------------------------------------------------------ Gcy1_Spur GYELEDRGLVPMK----------------------------------------------- Gcy2_Spur GYDVPERGIVAMK----------------------------------------------- Npr5_Spur GYVLEKRGLITIK----------------------------------------------- AqueK220_Aque LKKFDK------------------------------------------------------ AqueK221_Aque -YQLEYID-AIME----------------------------------------------- AqueK222_Aque GFQLECRGTLEIK----------------------------------------------- HSER_Hsap ---------------------------GRGN-ETTYWLTGMKDQKFNLPTP--------- CG10738_Dmel ---------------------------GKGD-QRTYWLLGEDEEARTRRTY--------- CG9783_Dmel ---------------------------GKGM-MNTFWLLGKKGFDKPLPAP--------- Gyc32E_Dmel ---------------------------GKGD-MRTYWLTKRQQPELTPDLI--------- Gyc76C_Dmel ---------------------------GKGD-VVTWWLTGANENAIQKKLV--------- CG4224_Dmel ---------------------------GKGE-MLTYWLEGEVPRPNSLISPSKLMLTRRS CG3216_Dmel ---------------------------GKGT-VTTYWLNSTSEGEARPPTP--------- KSGC_Mmus ---------------------------GKGE-QTTFWLKGKDGFPVPL--P--------- HSER_Mmus ---------------------------GRGT-ETTYWLTGMKDQEYNLPSP--------- CYGX_Mmus ---------------------------GKGL-EETYWLTGKVGFCRPLPTP--------- CYGF_Mmus ---------------------------GKGT-EETFWLVGKKGFTKPLPVP--------- CYGD_Mmus ---------------------------GKGI-EDTYWLVGRLGFNKPIPKP--------- ANPb_Mmus ---------------------------GKGK-MRTYWLLGEQKGP--------------- ANPa_Mmus ---------------------------GKGK-VRTYWLLGERGC---------------- odr-1_Cele ---------------------------GKGN-AARLKICCETFE---------------- gcy-9_Cele ---------------------------VSEK-SEK---------KAT------------- gcy-8_Cele ---------------------------GKGL-CMTYWLMGTKSEGSGRSGA--------- gcy-7_Cele ---------------------------GKGV-METFWLTGQGTGAVSGARH--------- gcy-6_Cele ---------------------------GKGV-MATYWLLKMDESAAP------------- gcy-5_Cele ---------------------------GKGV-METFWVLGKTDSDTKSLS---------- gcy-4_Cele ---------------------------GKGV-METYWLLGKMSLSNQST----------- gcy-3_Cele ---------------------------GKGV-METFWVLGRSGDIE-PSIS--------- gcy-27_Cele ---------------------------GKGE-VNCYWLNEHIHKDEE------------- gcy-25_Cele ---------------------------GKGA-CLTFWLTGEKDIMRRQSSR--------- gcy-23_Cele ---------------------------GKGP-VTSYWLLGKQSESQM------------- gcy-22_Cele ---------------------------GKGA-VQTHWLLTDDEIEA-------------- gcy-21_Cele ---------------------------GKGK-QMTYFVRGENSDMRRERII--------- gcy-20_Cele ---------------------------GKGV-METFWLLGEESGYTAPSKA--------- gcy-2_Cele ---------------------------GKGV-METFWVHGRIDDIAEPTEL--------- gcy-19_Cele ---------------------------GKGV-METFWVFERNNQFMGVSSN--------- gcy-18_Cele ---------------------------GKGT-CRTFWLEDRVGDAST------------- gcy-17_Cele ---------------------------GKGV-MNTYWLLGENDSVPVKSNM--------- gcy-15_Cele ---------------------------GKGK-QMTYFVRGENSDMRRERII--------- gcy-14_Cele ---------------------------GKGV-METYWLLGEQSRISVSAQA--------- gcy-13_Cele ---------------------------GKGV-MQTYWLLGMKE----------------- gcy-12_Cele ---------------------------GKGQ-MTTYWLNGRAGYEFTE-TI--------- gcy-11_Cele ---------------------------NKLE-VMTYWMNDYSKDARLARLV--------- gcy-1_Cele ---------------------------GKGV-METFWVHGRFGEME-PTEL--------- daf-11_Cele ---------------------------GIGR-ILTYWLEGVNAGEQVKVVE--------- C04H5.4_Cele ---------------------------KQDD-FVTYWLTGKDEDYFK------------- CYGF_Hsap ---------------------------GKGT-EETFWLIGKKGFMKPLPVP--------- ANPb_Hsap ---------------------------GKGK-MRTYWLLGERKGP--------------- ANPa_Hsap ---------------------------GKGK-VRTYWLLGERGS---------------- CYGD_Hsap ---------------------------GKGA-EDTFWLVGRRGFNKPIPKP--------- T01A4.1_Cele ---------------------------GKKM----------------------------- Npr1_Spur ---------------------------GKGT-QTTFWLKGERG----------------- Npr2_Spur LGMFKTLAGWHRPQVSGKRTVLNGMRTGKGS-QQTYWLTAEASTSVI------------- Gcy3_Spur ---------------------------GKGQ-LVTYWLISADPSYRRSSPF--------- Npr3_Spur ---------------------------GKGQ-QTTFWLLSQKDN---------------- Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ---------------------------GKGE-IHTFWLLGQDPSYKITKVK--------- Gcy2_Spur ---------------------------GKGS-LLTYWLVDQDPSYKRFKPR--------- Npr5_Spur ---------------------------GKGQ-MTTYWLLGTDTTIRPRYSI--------- AqueK220_Aque ----------------------------KNEDVVAYIVTAEDCVAMSE------------ AqueK221_Aque ---------------------------EDGN-SLPYYSYSAPFADLST------------ AqueK222_Aque ---------------------------GKGQ-MTTWWLKGEDKPSSSSSRR--------- HSER_Hsap ------------------------------------------------------------ CG10738_Dmel ------------------------------------------------------------ CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel ------------------------------------------------------------ Gyc76C_Dmel ------------------------------------------------------------ CG4224_Dmel SLKQPQRSQSHNLHKQYSELVVASPPPQLPPPAIALPPPPSPSKDSPNLRVKRKISSSSP CG3216_Dmel ------------------------------------------------------------ KSGC_Mmus ------------------------------------------------------------ HSER_Mmus ------------------------------------------------------------ CYGX_Mmus ------------------------------------------------------------ CYGF_Mmus ------------------------------------------------------------ CYGD_Mmus ------------------------------------------------------------ ANPb_Mmus ------------------------------------------------------------ ANPa_Mmus ------------------------------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ------------------------------------------------------------ gcy-8_Cele ------------------------------------------------------------ gcy-7_Cele ------------------------------------------------------------ gcy-6_Cele ------------------------------------------------------------ gcy-5_Cele ------------------------------------------------------------ gcy-4_Cele ------------------------------------------------------------ gcy-3_Cele ------------------------------------------------------------ gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------------------------------------------------ gcy-23_Cele ------------------------------------------------------------ gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele ------------------------------------------------------------ gcy-20_Cele ------------------------------------------------------------ gcy-2_Cele ------------------------------------------------------------ gcy-19_Cele ------------------------------------------------------------ gcy-18_Cele ------------------------------------------------------------ gcy-17_Cele ------------------------------------------------------------ gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ------------------------------------------------------------ gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele ------------------------------------------------------------ gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ------------------------------------------------------------ daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ------------------------------------------------------------ ANPb_Hsap ------------------------------------------------------------ ANPa_Hsap ------------------------------------------------------------ CYGD_Hsap ------------------------------------------------------------ T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------------------------------------------ Gcy3_Spur ------------------------------------------------------------ Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ------------------------------------------------------------ Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------------------------ AqueK222_Aque ------------------------------------------------------------ HSER_Hsap ------------------------------------------------------------ CG10738_Dmel ------------------------------------------------------------ CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel ------------------------------------------------------------ Gyc76C_Dmel ------------------------------------------------------------ CG4224_Dmel KLNGGGFDYHKTENHYLDTAAAAQRNCDIYSSRSLRDMEETSDSWELAHFRLPLSGALKS CG3216_Dmel ------------------------------------------------------------ KSGC_Mmus ------------------------------------------------------------ HSER_Mmus ------------------------------------------------------------ CYGX_Mmus ------------------------------------------------------------ CYGF_Mmus ------------------------------------------------------------ CYGD_Mmus ------------------------------------------------------------ ANPb_Mmus ------------------------------------------------------------ ANPa_Mmus ------------------------------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ------------------------------------------------------------ gcy-8_Cele ------------------------------------------------------------ gcy-7_Cele ------------------------------------------------------------ gcy-6_Cele ------------------------------------------------------------ gcy-5_Cele ------------------------------------------------------------ gcy-4_Cele ------------------------------------------------------------ gcy-3_Cele ------------------------------------------------------------ gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------------------------------------------------ gcy-23_Cele ------------------------------------------------------------ gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele ------------------------------------------------------------ gcy-20_Cele ------------------------------------------------------------ gcy-2_Cele ------------------------------------------------------------ gcy-19_Cele ------------------------------------------------------------ gcy-18_Cele ------------------------------------------------------------ gcy-17_Cele ------------------------------------------------------------ gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ------------------------------------------------------------ gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele ------------------------------------------------------------ gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ------------------------------------------------------------ daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ------------------------------------------------------------ ANPb_Hsap ------------------------------------------------------------ ANPa_Hsap ------------------------------------------------------------ CYGD_Hsap ------------------------------------------------------------ T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------------------------------------------ Gcy3_Spur ------------------------------------------------------------ Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ------------------------------------------------------------ Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------------------------ AqueK222_Aque ------------------------------------------------------------ HSER_Hsap ------------------------------------------------------------ CG10738_Dmel ------------------------------------------------------------ CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel ------------------------------------------------------------ Gyc76C_Dmel ------------------------------------------------------------ CG4224_Dmel HHHLNNNSHGYVHSNSSSNLSGILQPPPLGVQRTRLKPSPTISTLLTSARSEANASPGPE CG3216_Dmel ------------------------------------------------------------ KSGC_Mmus ------------------------------------------------------------ HSER_Mmus ------------------------------------------------------------ CYGX_Mmus ------------------------------------------------------------ CYGF_Mmus ------------------------------------------------------------ CYGD_Mmus ------------------------------------------------------------ ANPb_Mmus ------------------------------------------------------------ ANPa_Mmus ------------------------------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ------------------------------------------------------------ gcy-8_Cele ------------------------------------------------------------ gcy-7_Cele ------------------------------------------------------------ gcy-6_Cele ------------------------------------------------------------ gcy-5_Cele ------------------------------------------------------------ gcy-4_Cele ------------------------------------------------------------ gcy-3_Cele ------------------------------------------------------------ gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------------------------------------------------ gcy-23_Cele ------------------------------------------------------------ gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele ------------------------------------------------------------ gcy-20_Cele ------------------------------------------------------------ gcy-2_Cele ------------------------------------------------------------ gcy-19_Cele ------------------------------------------------------------ gcy-18_Cele ------------------------------------------------------------ gcy-17_Cele ------------------------------------------------------------ gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ------------------------------------------------------------ gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele ------------------------------------------------------------ gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ------------------------------------------------------------ daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ------------------------------------------------------------ ANPb_Hsap ------------------------------------------------------------ ANPa_Hsap ------------------------------------------------------------ CYGD_Hsap ------------------------------------------------------------ T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------------------------------------------ Gcy3_Spur ------------------------------------------------------------ Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ------------------------------------------------------------ Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------------------------ AqueK222_Aque ------------------------------------------------------------ HSER_Hsap ------------------------------------------------------------ CG10738_Dmel ------------------------------------------------------------ CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel ------------------------------------------------------------ Gyc76C_Dmel ------------------------------------------------------------ CG4224_Dmel TGSMGSGQLRIKFAEGDETPLLPTPPPLAAPPPIPQMVAASPQRSGSGQNIPADSSHYGF CG3216_Dmel ------------------------------------------------------------ KSGC_Mmus ------------------------------------------------------------ HSER_Mmus ------------------------------------------------------------ CYGX_Mmus ------------------------------------------------------------ CYGF_Mmus ------------------------------------------------------------ CYGD_Mmus ------------------------------------------------------------ ANPb_Mmus ------------------------------------------------------------ ANPa_Mmus ------------------------------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ------------------------------------------------------------ gcy-8_Cele ------------------------------------------------------------ gcy-7_Cele ------------------------------------------------------------ gcy-6_Cele ------------------------------------------------------------ gcy-5_Cele ------------------------------------------------------------ gcy-4_Cele ------------------------------------------------------------ gcy-3_Cele ------------------------------------------------------------ gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------------------------------------------------ gcy-23_Cele ------------------------------------------------------------ gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele ------------------------------------------------------------ gcy-20_Cele ------------------------------------------------------------ gcy-2_Cele ------------------------------------------------------------ gcy-19_Cele ------------------------------------------------------------ gcy-18_Cele ------------------------------------------------------------ gcy-17_Cele ------------------------------------------------------------ gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ------------------------------------------------------------ gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele ------------------------------------------------------------ gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ------------------------------------------------------------ daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ------------------------------------------------------------ ANPb_Hsap ------------------------------------------------------------ ANPa_Hsap ------------------------------------------------------------ CYGD_Hsap ------------------------------------------------------------ T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------------------------------------------ Gcy3_Spur ------------------------------------------------------------ Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ------------------------------------------------------------ Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------------------------ AqueK222_Aque ------------------------------------------------------------ HSER_Hsap ------------------P-----------------------------T----------- CG10738_Dmel ------------------E-----------------------------R----------- CG9783_Dmel ------------------P-----------------------------P----------- Gyc32E_Dmel ------------------S-----------------------------T----------- Gyc76C_Dmel ------------------D-----------------------------M----------- CG4224_Dmel LVKSYKQQCPPVAGSAVTQ----------------------------------------- CG3216_Dmel ------------------Q-----------------------------I----------- KSGC_Mmus ------------------E-----------------------------F----------- HSER_Mmus ------------------P-----------------------------T----------- CYGX_Mmus ------------------L-----------------------------S----------- CYGF_Mmus ------------------P-----------------------------P----------- CYGD_Mmus ------------------P-----------------------------D----------- ANPb_Mmus ------------------------------------------------------------ ANPa_Mmus ------------------------------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ------------------------------------------------------------ gcy-8_Cele ------------------Y------------------------LAPS------------- gcy-7_Cele ------------------V----------------------SAKK--------------- gcy-6_Cele ------------------------------------------------------------ gcy-5_Cele -----------------------------------------TRTTPP-I----------- gcy-4_Cele ---------------------------------------------PP-I----------- gcy-3_Cele -----------------------------------------NRSTPP-V----------- gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------S-----------------------------S----------- gcy-23_Cele ------------------------------------------------------------ gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele ------------------R-----------------------------E----------- gcy-20_Cele ------------------A----------------------PKV---------------- gcy-2_Cele ------------------R--------S-----------IC---KPSTV----------- gcy-19_Cele ------------------S--------GYQSDKKATNNGSSPESTPP-S----------- gcy-18_Cele ------------------------------------------------------------ gcy-17_Cele ------------------R----------------------------------------- gcy-15_Cele ------------------R-----------------------------E----------- gcy-14_Cele ------------------P----------------------REKTPE------------- gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele ------------------E-----------------------------D----------- gcy-11_Cele ------------------A-----------------------------H----------- gcy-1_Cele ------------------R--------S-----------ISNRSTPP-V----------- daf-11_Cele ------------------FQNDLNDELSRIMKKDGELLAAATALKPK-DKMTLAKEKVIA C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ------------------P-----------------------------P----------- ANPb_Hsap ------------------------------------------------------------ ANPa_Hsap ------------------------------------------------------------ CYGD_Hsap ------------------P-----------------------------D----------- T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------A----------------------------------------- Gcy3_Spur ------------------R-----------------------------T----------- Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ------------------------------------------------------------ Gcy2_Spur ------------------S-----------------------------E----------- Npr5_Spur ------------------D-----------------------------T----------- AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------------------------ AqueK222_Aque ------------------------------------------------------------ HSER_Hsap --------VENQQR--L------------------------------------------- CG10738_Dmel --------SQRRGS--R------------------------------------------- CG9783_Dmel --------IGLDES--L------------------------------------------- Gyc32E_Dmel --------VDTLDT--Y------------------------------------------- Gyc76C_Dmel ------------------------------------------------------------ CG4224_Dmel ------------------------------------------------------------ CG3216_Dmel --------LTTD-E--V------------------------------------------- KSGC_Mmus --------TE-------------------------------------------------- HSER_Mmus --------VENQQR--L------------------------------------------- CYGX_Mmus --------IKP-GD--P------------------------------------------- CYGF_Mmus --------VGKDGQ--V------------------------------------------- CYGD_Mmus --------LQP-GA--S------------------------------------------- ANPb_Mmus ------------------------------------------------------------ ANPa_Mmus ------------------------------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele --------I--------------------------------------------------- gcy-8_Cele --------MKSAGT--G------------------------------------------- gcy-7_Cele --------VSKKV---------------------C------------------------- gcy-6_Cele ------------------------------------------------------------ gcy-5_Cele --------TDENWPPQM-------------KEDLK------------------------- gcy-4_Cele --------TKVNHKPRKIA--SFT--DS-ELTNYS------------------------- gcy-3_Cele --------TQERFTVRA-------------PDTPE------------------------- gcy-27_Cele --------IEE------------------------------------------------- gcy-25_Cele --------CISQIK--FE------------------------------------------ gcy-23_Cele ------------------------------------------------------------ gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele --------RVKFAS--L-----------------KKAQIQEKTYEFSLNKLFIVKSFLKL gcy-20_Cele --------IQHRQ---------------------S------------------------- gcy-2_Cele --------ANERWITPP-------------APKPE------------------------- gcy-19_Cele --------TPPMHEVKANSPVRHRKPPSPSSPTLS------------------------- gcy-18_Cele ------------------------------------------------------------ gcy-17_Cele ----------KRE---------------------N------------------------- gcy-15_Cele --------RVKFAS--L------------------------------------------- gcy-14_Cele --------PPRRQ---------------------S------------------------- gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele --------KMVVPD-IF-----------------PRPNLKNRGS---------------- gcy-11_Cele --------QEKFP----------------------------------------------- gcy-1_Cele --------TNDRWIPN-------------------------------------------- daf-11_Cele ERKNEEERLQRQQ---T------------------------------------------- C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap --------VDKDGQ--V------------------------------------------- ANPb_Hsap ------------------------------------------------------------ ANPa_Hsap ------------------------------------------------------------ CYGD_Hsap --------LQP-GS--S------------------------------------------- T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------------------------------------------ Gcy3_Spur --------AEENAT--V------------------------------------------- Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ------------------------------------------------------------ Gcy2_Spur --------DVEEA---V------------------------------------------- Npr5_Spur --------AVSKK---I------------------------------------------- AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------------------------ AqueK222_Aque ------------------------------------------------------------ HSER_Hsap ------------Q-A------------------------EFS------------------ CG10738_Dmel ------------ALN------------------------KFI------------------ CG9783_Dmel ------------I-R------------------------NSITLKAQANKSRTSTNPSSS Gyc32E_Dmel -------------CS------------------------G-------------------- Gyc76C_Dmel ------------------------------------------------------------ CG4224_Dmel ------------------------------------------------------------ CG3216_Dmel ------------------------------------------------------------ KSGC_Mmus ------------------------------------------------------------ HSER_Mmus ------------Q-T------------------------EFS------------------ CYGX_Mmus ------------------------------------------------------------ CYGF_Mmus ------------------------------------------------------------ CYGD_Mmus ------------------------------------------------------------ ANPb_Mmus ------------------------------------------------------------ ANPa_Mmus ------------------------------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ------------------------------------------------------------ gcy-8_Cele ------------------------------------------------------------ gcy-7_Cele ------------------------------------------------------------ gcy-6_Cele ------------------------------------------------------------ gcy-5_Cele ------------------------------------------------------------ gcy-4_Cele ------------------------------------------------------------ gcy-3_Cele ------------------------------------------------------------ gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------------------------------------------------ gcy-23_Cele ------------------------------------------------------------ gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele LIRYLQMRRHPIS----------------------------------------------- gcy-20_Cele ------------------------------------------------------------ gcy-2_Cele ------------------------------------------------------------ gcy-19_Cele ------------------------------------------------------------ gcy-18_Cele ------------------------------------------------------------ gcy-17_Cele ------------------------------------------------------------ gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ------------------------------------------------------------ gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele ----------SWA----------------------------------------------- gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ------------------------------------------------------------ daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ------------------------------------------------------------ ANPb_Hsap ------------------------------------------------------------ ANPa_Hsap ------------------------------------------------------------ CYGD_Hsap ------------------------------------------------------------ T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------------------------------------------ Gcy3_Spur ------------GLF------------------------DST------------------ Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ------------------------------------------------------------ Gcy2_Spur ------------EDT------------------------DSL------------------ Npr5_Spur ------------STDTMISQDSLLSPSHRMSDAYDIPEDRLI------------------ AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------------------------ AqueK222_Aque ------------------------------------------------------------ HSER_Hsap --------------------------------------------D--------------- CG10738_Dmel --------------------------------------------Q--------------- CG9783_Dmel QSSSLAGESVEVKVEITPPTNADLASGTNLPNSYSLDSNSTNTIS----PNATLCPEFPG Gyc32E_Dmel -------------------------------------------------PR-E------- Gyc76C_Dmel -------------------------------------------------------MDM-- CG4224_Dmel ------------------------------------------------------------ CG3216_Dmel ------------------------------------------------------------ KSGC_Mmus ------------------------------------------------------------ HSER_Mmus --------------------------------------------D--------------- CYGX_Mmus ------------------------------------------------------------ CYGF_Mmus ------------------------------------------------------------ CYGD_Mmus ------------------------------------------------------------ ANPb_Mmus ------------------------------------------------------------ ANPa_Mmus ------------------------------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ------------------------------------------------------------ gcy-8_Cele ------------------------------------------------------------ gcy-7_Cele ------------------------------------------------------------ gcy-6_Cele ------------------------------------------------------------ gcy-5_Cele ------------------------------------------------------------ gcy-4_Cele ------------------------------------------------------------ gcy-3_Cele ------------------------------------------------------------ gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------------------------------------------------ gcy-23_Cele ------------------------------------------------------------ gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele ------------------------------------------------------------ gcy-20_Cele ------------------------------------------------------------ gcy-2_Cele ------------------------------------------------------------ gcy-19_Cele ------------------------------------------------------------ gcy-18_Cele ------------------------------------------------------------ gcy-17_Cele ------------------------------------------------------------ gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ------------------------------------------------------------ gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele ------------------------------------------------------------ gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ------------------------------------------------------------ daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ------------------------------------------------------------ ANPb_Hsap ------------------------------------------------------------ ANPa_Hsap ------------------------------------------------------------ CYGD_Hsap ------------------------------------------------------------ T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------------------------------------------ Gcy3_Spur --------------------------------------------HGNHSNR-H------- Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ------------------------------------------------------------ Gcy2_Spur ------------------------------------------------SEK-H------- Npr5_Spur --------------------------------------------E----EHMNKTDNA-- AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------------------------ AqueK222_Aque ------------------------------------------------------------ HSER_Hsap ------------------------------------------------------------ CG10738_Dmel -------------------G--TIKQ----AQEQ---ANEYGI------RS--------S CG9783_Dmel KTTPSSTSPQSRK-----LS--ELTPENLLNP---------------------------- Gyc32E_Dmel -------------------S-MEVSV----HQY----CSPASNNY----RLGSCNCDTKC Gyc76C_Dmel ---PPP-------------LFSRPRK----SPK--------------------------- CG4224_Dmel ------------------------------------------------------------ CG3216_Dmel ------------------------------------------------------------ KSGC_Mmus ------------------------------------------------------------ HSER_Mmus ------------------------------------------------------------ CYGX_Mmus --------WQDRI-----NQ--EIRT---------------------------------- CYGF_Mmus --------GHGLQ-----PA--EIAA---------------------------------- CYGD_Mmus --------NHGIS-----LQ--EIPP---------------------------------- ANPb_Mmus ------------------------------------------------------------ ANPa_Mmus ------------------------------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ------------------------------------------------------------ gcy-8_Cele ------------------FT--GMLG---------------------------------- gcy-7_Cele ------------------LD-IQITY---------------------------------- gcy-6_Cele ------------------------------------------------------------ gcy-5_Cele ------------------KR--AVTP---------------------------------- gcy-4_Cele ------------------FR--SVSP---------------------------------- gcy-3_Cele ------------------AR--SVSS---------------------------------- gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------LD--EADN---------------------------------- gcy-23_Cele ------------------------------------------------------------ gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele --------NHNVVTVKTCMR--TIPP---------------------------------- gcy-20_Cele ------------------IR--SISP---------------------------------- gcy-2_Cele ------------------IR--SVSS---------------------------------- gcy-19_Cele ------------------KR--SVSP---------------------------------- gcy-18_Cele ------------------------------------------------------------ gcy-17_Cele ------------------------T----------------------------------- gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ------------------VR--SISP---------------------------------- gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele --------NRLTALVPACPF--QRPS---------------------------------- gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ----------------------PSSS---------------------------------- daf-11_Cele ------------------LQ--EALE---------------------------------- C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap --------GHGLQ-----PV--EIAA---------------------------------- ANPb_Hsap ------------------------------------------------------------ ANPa_Hsap ------------------------------------------------------------ CYGD_Hsap --------NHGIS-----LQ--EIPP---------------------------------- T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------------------------------------------ Gcy3_Spur -------------------S--KISA----QPQ----KEPFAKRLEADGRP--------- Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ---PPP-------------Q--KLTQ------E--------------------------- Gcy2_Spur ----------------------KMKK----SPGKSYLRTPLGSTY---MAP--------S Npr5_Spur ---PRP-------------S--TIAE----KRE----ST--------------------- AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------------------------ AqueK222_Aque ----II-------------V--KSSG----GTE--------------------------- HSER_Hsap ------------------------------------------------------------ CG10738_Dmel L----------------------------------------------------------- CG9783_Dmel -----------------------------------------------------------N Gyc32E_Dmel L----------------------------------------------------------- Gyc76C_Dmel LNPDSRQPSIQAMHFCGTGSRRQSTVPRAMDGESTYSLQGSVRESPRMV----------- CG4224_Dmel ------------------------------------------------------------ CG3216_Dmel ------------------------------------------------------------ KSGC_Mmus ------------------------------------------------------------ HSER_Mmus ------------------------------------------------------------ CYGX_Mmus ------------------------------------------------------------ CYGF_Mmus ------------------------------------------------------------ CYGD_Mmus ------------------------------------------------------------ ANPb_Mmus ------------------------------------------------------------ ANPa_Mmus ------------------------------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ------------------------------------------------------------ gcy-8_Cele ------------------------------------------------------------ gcy-7_Cele ------------------------------------------------------------ gcy-6_Cele ------------------------------------------------------------ gcy-5_Cele ------------------------------------------------------------ gcy-4_Cele ------------------------------------------------------------ gcy-3_Cele ------------------------------------------------------------ gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------------------------------------------------ gcy-23_Cele ------------------------------------------------------------ gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele ------------------------------------------------------------ gcy-20_Cele ------------------------------------------------------------ gcy-2_Cele ------------------------------------------------------------ gcy-19_Cele ------------------------------------------------------------ gcy-18_Cele ------------------------------------------------------------ gcy-17_Cele ------------------------------------------------------------ gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ------------------------------------------------------------ gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele ------------------------------------------------------------ gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ------------------------------------------------------------ daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ------------------------------------------------------------ ANPb_Hsap ------------------------------------------------------------ ANPa_Hsap ------------------------------------------------------------ CYGD_Hsap ------------------------------------------------------------ T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------------------------------------------ Gcy3_Spur -A------------------------------------------NPNVCH---------- Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ------------------------------------------------------------ Gcy2_Spur TS------------------------------------------TPTTGM---------- Npr5_Spur SA------------------------------------------RPSVREHTDDQLMSEA AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------------------------ AqueK222_Aque L----------------------------------------------------------- HSER_Hsap ------------------------------------------------------------ CG10738_Dmel ------------------------------------------------------------ CG9783_Dmel SFNRL------------------------------------------------------- Gyc32E_Dmel ------------------------------------------------------------ Gyc76C_Dmel -----SKRDRD--------------RERPPINGLGAGHFVGGALLESAQASLSTLNHSET CG4224_Dmel ------------------------------------------------------------ CG3216_Dmel ------------------------------------------------------------ KSGC_Mmus ------------------------------------------------------------ HSER_Mmus ------------------------------------------------------------ CYGX_Mmus ------------------------------------------------------------ CYGF_Mmus ------------------------------------------------------------ CYGD_Mmus ------------------------------------------------------------ ANPb_Mmus ------------------------------------------------------------ ANPa_Mmus ------------------------------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ------------------------------------------------------------ gcy-8_Cele ------------------------------------------------------------ gcy-7_Cele ------------------------------------------------------------ gcy-6_Cele ------------------------------------------------------------ gcy-5_Cele ------------------------------------------------------------ gcy-4_Cele ------------------------------------------------------------ gcy-3_Cele ------------------------------------------------------------ gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------------------------------------------------ gcy-23_Cele ------------------------------------------------------------ gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele ------------------------------------------------------------ gcy-20_Cele ------------------------------------------------------------ gcy-2_Cele ------------------------------------------------------------ gcy-19_Cele ------------------------------------------------------------ gcy-18_Cele ------------------------------------------------------------ gcy-17_Cele ------------------------------------------------------------ gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ------------------------------------------------------------ gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele ------------------------------------------------------------ gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ------------------------------------------------------------ daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ------------------------------------------------------------ ANPb_Hsap ------------------------------------------------------------ ANPa_Hsap ------------------------------------------------------------ CYGD_Hsap ------------------------------------------------------------ T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------------------------------------------ Gcy3_Spur ------------------------------------------------------------ Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ------------------------------------------------------------ Gcy2_Spur ------------------------------------------------------------ Npr5_Spur DSRRIS----TGSWTDGGQESVRFGRSITPVKG--------------------------- AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------------------------ AqueK222_Aque ------------------------------------------------------------ HSER_Hsap ------------------------------------------------------------ CG10738_Dmel ------------------------------------------------------------ CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel ------------------------------------------------------------ Gyc76C_Dmel NETNCDMDGGSGGVSGSGSGLVRQPNALHKPLAMVRPHRIISAAQLPQLGDNDDDSADTL CG4224_Dmel ------------------------------------------------------------ CG3216_Dmel ------------------------------------------------------------ KSGC_Mmus ------------------------------------------------------------ HSER_Mmus ------------------------------------------------------------ CYGX_Mmus ------------------------------------------------------------ CYGF_Mmus ------------------------------------------------------------ CYGD_Mmus ------------------------------------------------------------ ANPb_Mmus ------------------------------------------------------------ ANPa_Mmus ------------------------------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ------------------------------------------------------------ gcy-8_Cele ------------------------------------------------------------ gcy-7_Cele ------------------------------------------------------------ gcy-6_Cele ------------------------------------------------------------ gcy-5_Cele ------------------------------------------------------------ gcy-4_Cele ------------------------------------------------------------ gcy-3_Cele ------------------------------------------------------------ gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------------------------------------------------ gcy-23_Cele ------------------------------------------------------------ gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele ------------------------------------------------------------ gcy-20_Cele ------------------------------------------------------------ gcy-2_Cele ------------------------------------------------------------ gcy-19_Cele ------------------------------------------------------------ gcy-18_Cele ------------------------------------------------------------ gcy-17_Cele ------------------------------------------------------------ gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ------------------------------------------------------------ gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele ------------------------------------------------------------ gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ------------------------------------------------------------ daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ------------------------------------------------------------ ANPb_Hsap ------------------------------------------------------------ ANPa_Hsap ------------------------------------------------------------ CYGD_Hsap ------------------------------------------------------------ T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------------------------------------------ Gcy3_Spur ------------------------------------------------------------ Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ------------------------------------------------------------ Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------------------------ AqueK222_Aque ------------------------------------------------------------ HSER_Hsap ------------------------------------------------------------ CG10738_Dmel ------------------------------------------------------------ CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel -YS--------------------------------------------------------- Gyc76C_Dmel L--------RESRS---------------------------------------------- CG4224_Dmel ------------------------------------------------------------ CG3216_Dmel ------------------------------------------------------------ KSGC_Mmus ------------------------------------------------------------ HSER_Mmus ------------------------------------------------------------ CYGX_Mmus ------------------------------------------------------------ CYGF_Mmus ------------------------------------------------------------ CYGD_Mmus ------------------------------------------------------------ ANPb_Mmus ------------------------------------------------------------ ANPa_Mmus ------------------------------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ------------------------------------------------------------ gcy-8_Cele ------------------------------------------------------------ gcy-7_Cele ------------------------------------------------------------ gcy-6_Cele ------------------------------------------------------------ gcy-5_Cele ------------------------------------------------------------ gcy-4_Cele ------------------------------------------------------------ gcy-3_Cele ------------------------------------------------------------ gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------------------------------------------------ gcy-23_Cele ------------------------------------------------------------ gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele ------------------------------------------------------------ gcy-20_Cele ------------------------------------------------------------ gcy-2_Cele ------------------------------------------------------------ gcy-19_Cele ------------------------------------------------------------ gcy-18_Cele ------------------------------------------------------------ gcy-17_Cele ------------------------------------------------------------ gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ------------------------------------------------------------ gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele ------------------------------------------------------------ gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ------------------------------------------------------------ daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ------------------------------------------------------------ ANPb_Hsap ------------------------------------------------------------ ANPa_Hsap ------------------------------------------------------------ CYGD_Hsap ------------------------------------------------------------ T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------------------------------------------ Gcy3_Spur -NDSDSAIWFHYLTITIP------------------------------------------ Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ------------------------------------------------------------ Gcy2_Spur -KS--------------------------------------------------------- Npr5_Spur LH--------------VPSRLADNNQAAIMDERAGDGVRPSYVTDDRATPLGKESGDEGG AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------------------------ AqueK222_Aque ------------------------------------------------------------ HSER_Hsap --------------------MI-------------------------------------- CG10738_Dmel -----------------------------------------KQKNLP------------- CG9783_Dmel ----------------------------------------------PSSTGGSSSRLYKK Gyc32E_Dmel -------------------------R--------------RSDDNVT------------- Gyc76C_Dmel ------------------------------------------LDPM-------------- CG4224_Dmel ------------------------------------------------------------ CG3216_Dmel ------------------------------------------------------------ KSGC_Mmus ------------------------------------------------------------ HSER_Mmus --------------------MI-------------------------------------- CYGX_Mmus ------------------------------------------------------------ CYGF_Mmus ------------------------------------------------------------ CYGD_Mmus ------------------------------------------------------------ ANPb_Mmus ------------------------------------------------------------ ANPa_Mmus ------------------------------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ------------------------------------------------------------ gcy-8_Cele ------------------------------------------------------------ gcy-7_Cele ------------------------------------------------------------ gcy-6_Cele ------------------------------------------------------------ gcy-5_Cele ------------------------------------------------------------ gcy-4_Cele ------------------------------------------------------------ gcy-3_Cele ------------------------------------------------------------ gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------------------------------------------------ gcy-23_Cele ------------------------------------------------------------ gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele ------------------------------------------------------------ gcy-20_Cele ------------------------------------------------------------ gcy-2_Cele ------------------------------------------------------------ gcy-19_Cele ------------------------------------------------------------ gcy-18_Cele ------------------------------------------------------------ gcy-17_Cele ------------------------------------------------------------ gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ------------------------------------------------------------ gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele ------------------------------------------------------------ gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ------------------------------------------------------------ daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ------------------------------------------------------------ ANPb_Hsap ------------------------------------------------------------ ANPa_Hsap ------------------------------------------------------------ CYGD_Hsap ------------------------------------------------------------ T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------------------------------------------ Gcy3_Spur -------------------------ERIVNSEHAFLFITGGSTKSSP------------- Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ------------------------------------------------------------ Gcy2_Spur -------------------------S--------------RSVQDIS------------- Npr5_Spur YDNPVMDPRGTVIEEKEESHSVTSPQ--------------HSLSPAP------------- AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------------------------ AqueK222_Aque -------------------------------------------YS--------------- HSER_Hsap ------------------------------------------------------------ CG10738_Dmel ------------------------------------------------------------ CG9783_Dmel IEEMMDLSSPYNHYKCLSPSESNLTQFYDGKYLYGSVAGGAGGGQAGGGACASIALSGSG Gyc32E_Dmel ------------------------------------------------------------ Gyc76C_Dmel ------------------------------------------------------------ CG4224_Dmel ------------------------------------------------------------ CG3216_Dmel ------------------------------------------------------------ KSGC_Mmus ------------------------------------------------------------ HSER_Mmus ------------------------------------------------------------ CYGX_Mmus ------------------------------------------------------------ CYGF_Mmus ------------------------------------------------------------ CYGD_Mmus ------------------------------------------------------------ ANPb_Mmus ------------------------------------------------------------ ANPa_Mmus ------------------------------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ------------------------------------------------------------ gcy-8_Cele ------------------------------------------------------------ gcy-7_Cele ------------------------------------------------------------ gcy-6_Cele ------------------------------------------------------------ gcy-5_Cele ------------------------------------------------------------ gcy-4_Cele ------------------------------------------------------------ gcy-3_Cele ------------------------------------------------------------ gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------------------------------------------------ gcy-23_Cele ------------------------------------------------------------ gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele ------------------------------------------------------------ gcy-20_Cele ------------------------------------------------------------ gcy-2_Cele ------------------------------------------------------------ gcy-19_Cele ------------------------------------------------------------ gcy-18_Cele ------------------------------------------------------------ gcy-17_Cele ------------------------------------------------------------ gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ------------------------------------------------------------ gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele ------------------------------------------------------------ gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ------------------------------------------------------------ daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ------------------------------------------------------------ ANPb_Hsap ------------------------------------------------------------ ANPa_Hsap ------------------------------------------------------------ CYGD_Hsap ------------------------------------------------------------ T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------------------------------------------ Gcy3_Spur ------------------------------------------------------------ Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ------------------------------------------------------------ Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------------------------ AqueK222_Aque ------------------------------------------------------------ HSER_Hsap -------------A----N-----SL---------------------------------- CG10738_Dmel --------------RN-------------------------------------------- CG9783_Dmel CGGGASRFDSKPGS----SRLLRRQFSLDRDDQQAKGEQQHHQHSLQANTYSGLVGGCGG Gyc32E_Dmel --------------NS-------------------------------------------- Gyc76C_Dmel ------------------P-----MQ---------------------------------- CG4224_Dmel ------------------------------------------------------------ CG3216_Dmel ------------------------------------------------------------ KSGC_Mmus ------------------------------------------------------------ HSER_Mmus -------------V----S-----AL---------------------------------- CYGX_Mmus ------------------------GF---------------------------------- CYGF_Mmus ------------------------------------------------------------ CYGD_Mmus ------------------------------------------------------------ ANPb_Mmus ------------------------------------------------------------ ANPa_Mmus ------------------------------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ------------------------------------------------------------ gcy-8_Cele ------------------------------------------------------------ gcy-7_Cele ------------------------------------------------------------ gcy-6_Cele ------------------------------------------------------------ gcy-5_Cele ------------------------------------------------------------ gcy-4_Cele ------------------------------------------------------------ gcy-3_Cele ------------------------------------------------------------ gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------------------------------------------------ gcy-23_Cele ------------------------------------------------------------ gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele ------------------------------------------------------------ gcy-20_Cele ------------------------------------------------------------ gcy-2_Cele ------------------------------------------------------------ gcy-19_Cele ------------------------------------------------------------ gcy-18_Cele ------------------------------------------------------------ gcy-17_Cele ------------------------------------------------------------ gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ------------------------------------------------------------ gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele ------------------------------------------------------------ gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ------------------------------------------------------------ daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ------------------------------------------------------------ ANPb_Hsap ------------------------------------------------------------ ANPa_Hsap ------------------------------------------------------------ CYGD_Hsap ------------------------------------------------------------ T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------------------------------------------ Gcy3_Spur --------------PDPRT-----DK---------------------------------- Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ------------------------------------------------------------ Gcy2_Spur -------------SSNLRE-----DA---------------------------------- Npr5_Spur --------------PSKS------------------------------------------ AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------------------------ AqueK222_Aque ------------------E-----GA---------------------------------- HSER_Hsap -----------------------------------------------Q-KRQ-------- CG10738_Dmel -----------------------------------------------S-LTR-------- CG9783_Dmel GVKSSMLDIPLLHDTTRSPKGTLTRSHKQNSASITQD----------L--EK-------- Gyc32E_Dmel -----------------------------------------------HGTSE-------- Gyc76C_Dmel -----------------------------------------------Q-LRK-------- CG4224_Dmel ------------------------------------------------------------ CG3216_Dmel ------------------------------------------------------------ KSGC_Mmus ------------------------------------------------------------ HSER_Mmus -----------------------------------------------Q-KRQ-------- CYGX_Mmus ----------------------------------A-K----------A-RQG-------- CYGF_Mmus ------------------------------------F----------Q-RRK-------- CYGD_Mmus ------------------------------------E----------R-RKK-------- ANPb_Mmus ------------------------------------------------------------ ANPa_Mmus ------------------------------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ------------------------------------------------------------ gcy-8_Cele ------------------------------------N----------S-AND-------- gcy-7_Cele ------------------------------------FCFKM-YEEF-Q-MDE-------- gcy-6_Cele ------------------------------------------------------------ gcy-5_Cele ---------------------------------------------Y-P---E-------- gcy-4_Cele ------------------------------------YVEN-L-SDNDD---E-------- gcy-3_Cele ------------------------------------HGSR-PSSNHNN---N-------- gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele -----------------------------------------------S-KKMF------- gcy-23_Cele ------------------------------------------------------------ gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele ------------------------------------Q----------E-VYI-------- gcy-20_Cele ------------------------------------ILEKN-AEGS-E-TSS-------- gcy-2_Cele ------------------------------------HGSR-PPSVYDP---L-------- gcy-19_Cele ------------------------------------IMEAKARDIHNE-ETE-------- gcy-18_Cele ------------------------------------------------------------ gcy-17_Cele ------------------------------------------------------------ gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ------------------------------------IIEKM-SEET-Q-KGL-------- gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele ------------------------------------D----------H-MNL-------- gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ------------------------------------HGSR-PSSVYDP---L-------- daf-11_Cele ------------------------------------E----------H-EEEIEMNEVLV C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ------------------------------------F----------Q-RRK-------- ANPb_Hsap ------------------------------------------------------------ ANPa_Hsap ------------------------------------------------------------ CYGD_Hsap ------------------------------------E----------R-RRK-------- T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------------------------------------------ Gcy3_Spur -----------------------------------------------E-IRR-------- Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ------------------------------------------------------------ Gcy2_Spur -----------------------------------------------Q-LRR-------- Npr5_Spur -------------------------------------------------VSP-------- AqueK220_Aque --------------------------------------------------DQ-------- AqueK221_Aque --------------------------------------------------SK-------- AqueK222_Aque -----------------------------------------------Q-LRS-------- HSER_Hsap ------------------A--AGI----------------------RS----------Q- CG10738_Dmel ------------------SSS--L----------------------------------E- CG9783_Dmel ------------------------I-EEIPLSPASSQHHSSLDSNLN-----------RS Gyc32E_Dmel ------------------FPK--V----------------------------------S- Gyc76C_Dmel ------------------R----------------------------------------- CG4224_Dmel ------------------------------------------------------------ CG3216_Dmel ------------------------------------------------------------ KSGC_Mmus ------------------------------------------------------------ HSER_Mmus ------------------A--SGK----------------------KS----------R- CYGX_Mmus -----------------------LA----------------------------------- CYGF_Mmus ------------------------A----------------------------------- CYGD_Mmus ------------------------L----------------------------------- ANPb_Mmus ------------------------------------------------------------ ANPa_Mmus ------------------------------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ------------------------------------------------------------ gcy-8_Cele ------------------------------------------------------------ gcy-7_Cele ------------------------I----------------------------------- gcy-6_Cele ------------------------------------------------------------ gcy-5_Cele ------------------------R----------------------------------- gcy-4_Cele ------------------------E----------------------------------- gcy-3_Cele ------------------------N----------------------------------- gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------------LN---------------------------------- gcy-23_Cele ------------------------------------------------------------ gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele ------------------SS----T----------------------------------- gcy-20_Cele ------------------------L----------------------------------- gcy-2_Cele ------------------------Q----------------------------------- gcy-19_Cele ------------------------A----------------------------------- gcy-18_Cele ------------------------------------------------------------ gcy-17_Cele ------------------------------------------------------------ gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ------------------------Y----------------------------------- gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele -------------------R----F----------------------------------- gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ------------------------Q----------------------------------- daf-11_Cele DEDEGEGKPKEVDLTSIVSTQMEELED--------------------------------- C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ------------------------A----------------------------------- ANPb_Hsap ------------------------------------------------------------ ANPa_Hsap ------------------------------------------------------------ CYGD_Hsap ------------------------L----------------------------------- T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------------------------------------------ Gcy3_Spur ------------------TSN--I----------------------A------------- Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ------------------------------------------------------------ Gcy2_Spur ------------------DSD--V----------------------VTRRRNSDISRTE- Npr5_Spur ------------------SSSDGD----------------------------------K- AqueK220_Aque ------------------------E----------------------------------- AqueK221_Aque ------------------------V----------------------------------- AqueK222_Aque ------------------S----------------------------------------- HSER_Hsap KPR--------------------R------------------------------------ CG10738_Dmel SPK--------------------------------------------------------- CG9783_Dmel PPS--------------------T------------------------------------ Gyc32E_Dmel EPA--------------------------------------------------------- Gyc76C_Dmel --------------HDRVKLPPSKLSKN----------------NSRSLDTGVSLISGNP CG4224_Dmel ------------------------------------------------------------ CG3216_Dmel ------------------------------------------------------------ KSGC_Mmus ------------------------------------------------------------ HSER_Mmus RPT--------------------R------------------------------------ CYGX_Mmus ------------------------------------------------------------ CYGF_Mmus ------------------------------------------------------------ CYGD_Mmus ------------------------------------------------------------ ANPb_Mmus ------------------------------------------------------------ ANPa_Mmus ------------------------------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ------------------------------------------------------------ gcy-8_Cele ------------------------------------------------------------ gcy-7_Cele ------------------------------------------------------------ gcy-6_Cele ------------------------------------------------------------ gcy-5_Cele ------------------------------------------------------------ gcy-4_Cele ------------------------------------------------------------ gcy-3_Cele ------------------------------------------------------------ gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------------------------------------------------ gcy-23_Cele ------------------------------------------------------------ gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele LP---------------------------------------------------------- gcy-20_Cele ------------------------------------------------------------ gcy-2_Cele ------------------------------------------------------------ gcy-19_Cele ------------------------------------------------------------ gcy-18_Cele ------------------------------------------------------------ gcy-17_Cele ------------------------------------------------------------ gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ------------------------------------------------------------ gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele EP---------------------------------------------------------- gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ------------------------------------------------------------ daf-11_Cele EP---------------------------------------------------------- C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ------------------------------------------------------------ ANPb_Hsap ------------------------------------------------------------ ANPa_Hsap ------------------------------------------------------------ CYGD_Hsap ------------------------------------------------------------ T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------------------------------------------ Gcy3_Spur ------VG---------------------------------------------------- Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ------------------------------------------------------------ Gcy2_Spur LPKNGKNGYTLLPMDCDDSLPCSKSEEVEIRTTDFGDGSGDCSSQARSVS---------- Npr5_Spur KRR--------------------------------------------------------- AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------------------------ AqueK222_Aque ------------------------------------------------------------ HSER_Hsap ------------------------------------------------------------ CG10738_Dmel ------------------------------------------------------------ CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel ------------------------------------------------------------ Gyc76C_Dmel NGEVHSSQLDLDNEMTANPVDATDGYDDELGLLMRHDNGQLPALRYSGSFPNAQISIVPT CG4224_Dmel ------------------------------------------------------------ CG3216_Dmel ------------------------------------------------------------ KSGC_Mmus ------------------------------------------------------------ HSER_Mmus ------------------------------------------------------------ CYGX_Mmus ------------------------------------------------------------ CYGF_Mmus ------------------------------------------------------------ CYGD_Mmus ------------------------------------------------------------ ANPb_Mmus ------------------------------------------------------------ ANPa_Mmus ------------------------------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ------------------------------------------------------------ gcy-8_Cele ------------------------------------------------------------ gcy-7_Cele ------------------------------------------------------------ gcy-6_Cele ------------------------------------------------------------ gcy-5_Cele ------------------------------------------------------------ gcy-4_Cele ------------------------------------------------------------ gcy-3_Cele ------------------------------------------------------------ gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------------------------------------------------ gcy-23_Cele ------------------------------------------------------------ gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele ------------------------------------------------------------ gcy-20_Cele ------------------------------------------------------------ gcy-2_Cele ------------------------------------------------------------ gcy-19_Cele ------------------------------------------------------------ gcy-18_Cele ------------------------------------------------------------ gcy-17_Cele ------------------------------------------------------------ gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ------------------------------------------------------------ gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele ------------------------------------------------------------ gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ------------------------------------------------------------ daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ------------------------------------------------------------ ANPb_Hsap ------------------------------------------------------------ ANPa_Hsap ------------------------------------------------------------ CYGD_Hsap ------------------------------------------------------------ T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------------------------------------------ Gcy3_Spur ------------------------------------------------------------ Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ------------------------------------------------------------ Gcy2_Spur ------------------------------------------------------------ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------------------------ AqueK222_Aque ------------------------------------------------------------ HSER_Hsap ------------------------------------------------------------ CG10738_Dmel ------------------------------------------------------------ CG9783_Dmel ------------------------------------------------------------ Gyc32E_Dmel ------------------------------------------------------------ Gyc76C_Dmel GRSAGGGGGGREGGGSNCAKHLNNNCNGGVNVEDDLESPL-LQR---------------- CG4224_Dmel ------------------------------------------------------------ CG3216_Dmel ------------------------------------------------------------ KSGC_Mmus ------------------------------------------------------------ HSER_Mmus ------------------------------------------------------------ CYGX_Mmus ------------------------------------------------------------ CYGF_Mmus ------------------------------------------------------------ CYGD_Mmus ------------------------------------------------------------ ANPb_Mmus ------------------------------------------------------------ ANPa_Mmus ------------------------------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ------------------------------------------------------------ gcy-8_Cele ------------------------------------------------------------ gcy-7_Cele ------------------------------------------------------------ gcy-6_Cele ------------------------------------------------------------ gcy-5_Cele ------------------------------------------------------------ gcy-4_Cele ------------------------------------------------------------ gcy-3_Cele ------------------------------------------------------------ gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------------------------------------------------ gcy-23_Cele ------------------------------------------------------------ gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele ------------------------------------------------------------ gcy-20_Cele ------------------------------------------------------------ gcy-2_Cele ------------------------------------------------------------ gcy-19_Cele ------------------------------------------------------------ gcy-18_Cele ------------------------------------------------------------ gcy-17_Cele ------------------------------------------------------------ gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ------------------------------------------------------------ gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele ------------------------------------------------------------ gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ------------------------------------------------------------ daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ------------------------------------------------------------ ANPb_Hsap ------------------------------------------------------------ ANPa_Hsap ------------------------------------------------------------ CYGD_Hsap ------------------------------------------------------------ T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------------------------------------------ Gcy3_Spur ------------------------------------------------------AGIVGA Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ------------------------------------------------------------ Gcy2_Spur --------------------------------------ACSLNRCEVVGEEATMNGAVSQ Npr5_Spur ------------------------------------------------------------ AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------------------------ AqueK222_Aque ------------------------------------------------------------ HSER_Hsap -VA-------------------------------------------S-YK---------- CG10738_Dmel KLR-------------------------------------------F-AAG-S------- CG9783_Dmel -LEAQSPPLPPMSPPQLSAPTSPAPSRTLNGIYAHNSNSTSSHGAAN-NN---------- Gyc32E_Dmel QVN-------------------------------------------C-NQL-C-VCRLNS Gyc76C_Dmel Q----------------------------------------------------------- CG4224_Dmel ------------------------------------------------------------ CG3216_Dmel ------------------------------------------------------------ KSGC_Mmus ------------------------------------------------------------ HSER_Mmus -VA-------------------------------------------S-YK---------- CYGX_Mmus ------------------------------------------------------------ CYGF_Mmus ------------------------------------------------------------ CYGD_Mmus ------------------------------------------------------------ ANPb_Mmus ------------------------------------------------------------ ANPa_Mmus ------------------------------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ------------------------------------------------------------ gcy-8_Cele ------------------------------------------------------------ gcy-7_Cele ------------------------------------------------------------ gcy-6_Cele ------------------------------------------------------------ gcy-5_Cele ------------------------------------------------------------ gcy-4_Cele ------------------------------------------------------------ gcy-3_Cele ------------------------------------------------------------ gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------------------------------------------------ gcy-23_Cele ------------------------------------------------------------ gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele ------------------------------------------------------------ gcy-20_Cele ------------------------------------------------------------ gcy-2_Cele ------------------------------------------------------------ gcy-19_Cele ------------------------------------------------------------ gcy-18_Cele ------------------------------------------------------------ gcy-17_Cele ------------------------------------------------------------ gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ------------------------------------------------------------ gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele ------------------------------------------------------------ gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ------------------------------------------------------------ daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ------------------------------------------------------------ ANPb_Hsap ------------------------------------------------------------ ANPa_Hsap ------------------------------------------------------------ CYGD_Hsap ------------------------------------------------------------ T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------------------------------------------ Gcy3_Spur TLR-------------------------------------------QV-----------P Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur AI---------------------------------------------------------- Gcy2_Spur RSR-------------------------------------------NNSQG-S------K Npr5_Spur NLR-------------------------------------------S-GARTENNNYLSP AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------------------------ AqueK222_Aque S----------------------------------------------------------- HSER_Hsap ------KGT--------------------------------------------------- CG10738_Dmel ------------------------------------------------------------ CG9783_Dmel ------NGT--------------------------------------------------- Gyc32E_Dmel SQMFN------------------------------------------------------- Gyc76C_Dmel -ASLSV-----PPEEMLAHNKRWHSLEHMDGPGGHGGNSVSYAADIDNRHPGDLDFFSGS CG4224_Dmel ------------------------------------------------------------ CG3216_Dmel ------------------------------------------------------------ KSGC_Mmus ------------------------------------------------------------ HSER_Mmus ------KGF--------------------------------------------------- CYGX_Mmus ------------------------------------------------------------ CYGF_Mmus ------------------------------------------------------------ CYGD_Mmus ------------------------------------------------------------ ANPb_Mmus ------------------------------------------------------------ ANPa_Mmus ------------------------------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ------------------------------------------------------------ gcy-8_Cele ------------------------------------------------------------ gcy-7_Cele ------------------------------------------------------------ gcy-6_Cele ------------------------------------------------------------ gcy-5_Cele ------------------------------------------------------------ gcy-4_Cele ------------------------------------------------------------ gcy-3_Cele ------------------------------------------------------------ gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ------------------------------------------------------------ gcy-23_Cele ------------------------------------------------------------ gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele ------------------------------------------------------------ gcy-20_Cele ------------------------------------------------------------ gcy-2_Cele ------------------------------------------------------------ gcy-19_Cele ------------------------------------------------------------ gcy-18_Cele ------------------------------------------------------------ gcy-17_Cele ------------------------------------------------------------ gcy-15_Cele ------------------------------------------------------------ gcy-14_Cele ------------------------------------------------------------ gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele ------------------------------------------------------------ gcy-11_Cele ------------------------------------------------------------ gcy-1_Cele ------------------------------------------------------------ daf-11_Cele ------------------------------------------------------------ C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ------------------------------------------------------------ ANPb_Hsap ------------------------------------------------------------ ANPa_Hsap ------------------------------------------------------------ CYGD_Hsap ------------------------------------------------------------ T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------------------------------------------ Gcy3_Spur NQ--P------------------------------------------------------- Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur ------------------------------------------------------------ Gcy2_Spur TK--TKKNSTTD------------------------------------------------ Npr5_Spur AK--R-KNA--------------------------------------------------- AqueK220_Aque ------------------------------------------------------------ AqueK221_Aque ------------------------------------------------------------ AqueK222_Aque -AVLRT------------------------------------------------------ HSER_Hsap ----------------------------------------------------L------E CG10738_Dmel ----------------------------------------------------L------L CG9783_Dmel ----------------------------------------------------H------P Gyc32E_Dmel ----------------------------------------------------N------R Gyc76C_Dmel SNQHHRSKAAGGSKLTNWMTNIFKGNGVRSGEARRVGILPSGVHGARTGFTDM------A CG4224_Dmel ------------------------------------------------------------ CG3216_Dmel ------------------------------------------------------------ KSGC_Mmus ------------------------------------------------------------ HSER_Mmus ----------------------------------------------------L------E CYGX_Mmus ------------------------------------------------------------ CYGF_Mmus ------------------------------------------------------------ CYGD_Mmus ------------------------------------------------------------ ANPb_Mmus ------------------------------------------------------------ ANPa_Mmus ------------------------------------------------------------ odr-1_Cele ------------------------------------------------------------ gcy-9_Cele ------------------------------------------------------------ gcy-8_Cele -----------------------------------------------------------Y gcy-7_Cele ----------------------------------------------------H------R gcy-6_Cele ------------------------------------------------------------ gcy-5_Cele ----------------------------------------------------Q------R gcy-4_Cele ----------------------------------------------------I------R gcy-3_Cele ----------------------------------------------------D------P gcy-27_Cele ------------------------------------------------------------ gcy-25_Cele ----------------------------------------------------P------Y gcy-23_Cele ------------------------------------------------------------ gcy-22_Cele ------------------------------------------------------------ gcy-21_Cele ----------------------------------------------------Y---EDSE gcy-20_Cele ----------------------------------------------------S------V gcy-2_Cele ----------------------------------------------------D------H gcy-19_Cele ----------------------------------------------------L------Y gcy-18_Cele ------------------------------------------------------------ gcy-17_Cele ------------------------------------------------------------ gcy-15_Cele -----------------------------------------------------------K gcy-14_Cele ----------------------------------------------------S------A gcy-13_Cele ------------------------------------------------------------ gcy-12_Cele ----------------------------------------------------S----NLS gcy-11_Cele ---------------------------------------------------------HLE gcy-1_Cele ----------------------------------------------------G------H daf-11_Cele ----------------------------------------------------AGRTIGHG C04H5.4_Cele ------------------------------------------------------------ CYGF_Hsap ------------------------------------------------------------ ANPb_Hsap ------------------------------------------------------------ ANPa_Hsap ------------------------------------------------------------ CYGD_Hsap ------------------------------------------------------------ T01A4.1_Cele ------------------------------------------------------------ Npr1_Spur ------------------------------------------------------------ Npr2_Spur ------------------------------------------------------------ Gcy3_Spur ----------------------------------------------------I------V Npr3_Spur ------------------------------------------------------------ Npr4_Spur ------------------------------------------------------------ Gcy1_Spur -----------------------------------------------------------E Gcy2_Spur -----------------------SGI----------------------GSNGN------S Npr5_Spur ----------------------------------------------------I------T AqueK220_Aque -----------------------------------------------------------K AqueK221_Aque -----------------------------------------------------------S AqueK222_Aque ----------------------------------------------------P------N HSER_Hsap Y-LQLNTTDKESTYF CG10738_Dmel ---EHHRYHRFDNIY CG9783_Dmel G-PELTLNAEQLLSR Gyc32E_Dmel ---GPRSAPSITFRL Gyc76C_Dmel ---ASAAARDRESIV CG4224_Dmel -------PLLAKINS CG3216_Dmel ---P-FPLLFAGMGK KSGC_Mmus ------EEAKVSEIL HSER_Mmus Y-MQLNNSDHDSTYF CYGX_Mmus ---EPRKSGEAGPGP CYGF_Mmus ---E-R--QLVRNKP CYGD_Mmus ---E-KARPGQFTGK ANPb_Mmus -----------PGLL ANPa_Mmus -----------STRG odr-1_Cele ---------THSIDL gcy-9_Cele -----IYNYREKESV gcy-8_Cele ---SLNLKNPTGLQR gcy-7_Cele ---QETLKSDEQLSD gcy-6_Cele -------KILKKKQD gcy-5_Cele ---SGKSKMDTLKVV gcy-4_Cele ---RVLRREMMRVEV gcy-3_Cele ---LYRQYKMDTLKI gcy-27_Cele -----SGTISHPLES gcy-25_Cele ---ISIITSLVSGNN gcy-23_Cele -----QQQNFSQLGI gcy-22_Cele --------KENGESI gcy-21_Cele ---EEASTVYDTVTY gcy-20_Cele ----DQAGDNNSETV gcy-2_Cele ---RKFKMDTLKVAN gcy-19_Cele ---RQFRRQETLALI gcy-18_Cele -----TNYIQNVEGV gcy-17_Cele ----PSMARSITPEI gcy-15_Cele ---KAQIQEKTYEFS gcy-14_Cele ---YKDFNNGNECVS gcy-13_Cele ------------ESA gcy-12_Cele ---SSDSTSEEYLNN gcy-11_Cele ----HLIHKFNKGVR gcy-1_Cele ---QKFKMDTLKVAN daf-11_Cele ---RLDSQASTIPDN C04H5.4_Cele -------KKNNTFDF CYGF_Hsap ---E-R--QLVRNKP ANPb_Hsap -----------PGLL ANPa_Hsap -----------STRG CYGD_Hsap ---E-KAR--PGQFS T01A4.1_Cele ----------VTEFN Npr1_Spur -------------CS Npr2_Spur -------CPVTKVEV Gcy3_Spur ---FKVTLSRKDMKI Npr3_Spur ------------DKG Npr4_Spur --------------E Gcy1_Spur ----IAANRVIPDDV Gcy2_Spur ---SRDCNMHNEIFL Npr5_Spur LHSSGSSGKAGVSKA AqueK220_Aque ---F-DSVANPLDKI AqueK221_Aque ---LTLSTGSKSQCE AqueK222_Aque ---RVIINIPGTPMQ