CLUSTAL W (1.83) multiple sequence alignment SgK288_Hsap MAADPTE----------------------------------------------------- RIPK3_Hsap MSCVKLWP-S-G------------------------------------------------ RIPK2_Hsap MNGEAICS---------------------------------------------------- RIPK1_Hsap MQPDMSLN---------------------------------------------------- ANKRD3_Mmus MEGEGRGR---------------------------------------------------- ANKRD3_Hsap MEGDGGTP---------------------------------------------------- RIPK1_Mmus MQPDMSLD---------------------------------------------------- RIPK2_Mmus MNGDAICS---------------------------------------------------- RIPK3_Mmus MSSVKLWP-T-G------------------------------------------------ SgK288_Mmus MVPHRARR-LL------------------------------------------------- ANKK2_Spur MLVNGLDYCHIM------------------------------------------------ ANKK1_Spur MALEAGCD-EVD------------------------------------------------ ANKK3_Spur MAERAANE-PSDDDKALLGAALNGHLDVVKYLTGQGAQIETRDNDDETPLHCASRNGHLD ANKK6_Spur MMH--------------------------------------------------------- ank2_Spur MAKRAVNE-PAEVDKALLRAALNGCFEMVVYLVGQGAQIE-------------------- ANKK5_Spur MAERAANE-PTEVDKSLAVAALYGRVNVVKYLVGEGAQID-------------------- ank1_Spur MAERAANE-PAGTYRALHLAAANGDVNEVQYLIGQGTHID-------------------- ANKK4_Spur MAERAANE-PAGSDKALLRAALNGHFDLVRYLVGQGAYIET------------------- * SgK288_Hsap ------------------------------------------------------------ RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap ------------------------------------------------------------ ANKRD3_Mmus ------------------------------------------------------------ ANKRD3_Hsap ------------------------------------------------------------ RIPK1_Mmus ------------------------------------------------------------ RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus ------------------------------------------------------------ ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur ------------------------------------------------------------ ANKK3_Spur VVKYLIGQEAQVDYPTKNGTTALFLASNAGHRDLVEYLVGKGAQVEKGGKNGFTPLHAAS ANKK6_Spur ------------------------------------------------------------ ank2_Spur ----------------------------------------------KGGENGFTPLHAAS ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur -----------------------------------------------CDIHGQTSLHYAS SgK288_Hsap ------------------------------------------------------------ RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap ------------------------------------------------------------ ANKRD3_Mmus ------------------------------------------------------------ ANKRD3_Hsap ------------------------------------------------------------ RIPK1_Mmus ------------------------------------------------------------ RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus ------------------------------------------------------------ ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur ------------------------------------------------------------ ANKK3_Spur QEGHIDVVEYLVGQGAQIDTCDSDGAATPLHGASRNGHLDVVKYLIGQGAQIDKPTKLGG ANKK6_Spur ------------------------------------------------------------ ank2_Spur QDGHLDV----------------------------------VEYLVGQGAHIDKPNEIGT ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur NNGHVDV----------------------------------VKFLIGQRARIDKPSKRGA SgK288_Hsap ------------------------------------------------------------ RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap ------------------------------------------------------------ ANKRD3_Mmus ------------------------------------------------------------ ANKRD3_Hsap ------------------------------------------------------------ RIPK1_Mmus ------------------------------------------------------------ RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus ------------------------------------------------------------ ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur ------------------------------------------------------------ ANKK3_Spur TAILFASGEGHRDIVEYLVRQGAQIDTCDIDDQTPLHGASRNGHLDVVKYLIGQGAQINK ANKK6_Spur ------------------------------------------------------------ ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur TALLFASGVGDRDIVEYLVGQGAQIDTCDIDGQTPLHSSSRNGHLDVVKFLIGQGARIDK SgK288_Hsap ------------------------------------------------------------ RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap ------------------------------------------------------------ ANKRD3_Mmus ------------------------------------------------------------ ANKRD3_Hsap ------------------------------------------------------------ RIPK1_Mmus ------------------------------------------------------------ RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus ------------------------------------------------------------ ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur ------------------------------------------------------------ ANKK3_Spur PTKLGATALLFASNAGHRDVAEYLVGQGAQVERGAFNGLTPVLTASEKGHLDVVEYLVGQ ANKK6_Spur ------------------------------------------------------------ ank2_Spur ------TALILASDAGHLDVVQYLVSHGAQVERGDNNGLTPLHAASQKGHLDVVEYLVGQ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur PTKSDETALLFASGVGHR---------------------------------DVVEYLVGQ SgK288_Hsap ------------------------------------------------------------ RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap ------------------------------------------------------------ ANKRD3_Mmus ------------------------------------------------------------ ANKRD3_Hsap ------------------------------------------------------------ RIPK1_Mmus ------------------------------------------------------------ RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus ------------------------------------------------------------ ANKK2_Spur ----------------------------------------------------------TA ANKK1_Spur ------------------------------------------------------------ ANKK3_Spur GAQIETLNKYDETPLHCSSRNGHLDVVKYLIRQGAQIDKPTELGITALVFGSDAGHRNIV ANKK6_Spur ------------------------------------------------------------ ank2_Spur GAQIETRNNEDSTPLHYASHNGHLDVVKCLIGQGAQIDKPNEFGATALHSGSAAGHRDLV ANKK5_Spur --------------------------------------ACGKEGYTPLFNASANGHLDVV ank1_Spur --------------------------------------TYDEDGNTPLLYASTNRYLGVV ANKK4_Spur GAQVERGTNNGFTPLHAASTKGHLDLVAYLVGRGAQVERGDNTGWTPLLRASQGGHLDVV SgK288_Hsap ------------------------------------------------------------ RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap ------------------------------------------------------------ ANKRD3_Mmus ------------------------------------------------------------ ANKRD3_Hsap ------------------------------------------------------------ RIPK1_Mmus ------------------------------------------------------------ RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus ------------------------------------------------------------ ANKK2_Spur KYFVF---------------------------YFD------------------------- ANKK1_Spur ------------------------------------------------------------ ANKK3_Spur EYLVGQGAQVERGS-NSGLTPLIAASEKGHIDVVKYLFGQGAKVKKGNNNGITPLHAAST ANKK6_Spur ------------------------------------------------------------ ank2_Spur EYLVGQGAQVEKCDNNNGMTPLHAASQKGHLDVVEYLVGQGAQVEKGGKNGFTPLHVASQ ANKK5_Spur QYLVDHRAQVEKGD-IDGHRPLHIASGNGNLDIVKYLVDQGAQVESGDNDGETPLHIASF ank1_Spur QYLVDQGADVDKGN-IGGSTPLHFASGWGFLDVVQCLVGNKAKINKLDDDGNTALYSASK ANKK4_Spur QYLLGQAAQVEIGD-NTGWTPLHAASNNGHVDVVQYLVSQGAQVERGDNNGLTPLQDASH SgK288_Hsap ------------------------------------------------------------ RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap ------------------------------------------------------------ ANKRD3_Mmus ------------------------------------------------------------ ANKRD3_Hsap ------------------------------------------------------------ RIPK1_Mmus ------------------------------------------------------------ RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus ------------------------------------------------------------ ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur ------------------------------------------------------------ ANKK3_Spur QGHLDVVRYLVGQGAQIDTC-DIHGQTPLHCSSCNGHLDVVKYLIGQGAQIDKPTKLGGT ANKK6_Spur ------------------------------------------------------------ ank2_Spur EGHLDVVEYLVGQGAQIETMIEKYDETPLHCSSCNGHLDVVKYLIGQEAQVDYPNKNGIT ANKK5_Spur LGRLEVVQYLVGQKA----------------------------------KINVI------ ank1_Spur QGHLHVVEYLVGQGAQVEKV-DNKGSTSLIIASAKGHIDVVKYLISKGANINKP------ ANKK4_Spur KGHRDIVEYLVGQGAQIDTC-DIHGQTSLHYASIKGHLDVVKYLIGQGAQIDKPTKLGAT SgK288_Hsap ------------------------------------------------------------ RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap ------------------------------------------------------------ ANKRD3_Mmus ------------------------------------------------------------ ANKRD3_Hsap ------------------------------------------------------------ RIPK1_Mmus ------------------------------------------------------------ RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus ------------------------------------------------------------ ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur ------------------------------------------------------------ ANKK3_Spur AILFASGEGHRDIVEYLVRQGAQIDTCDIDDQTPLHCSSCYGHLDVVKYLIGQGAQIDKP ANKK6_Spur ------------------------------------------------------------ ank2_Spur ALFFASNAGHRDLVE--------------------------------------------- ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ALHCSSHNGHR------------------------------------------------- SgK288_Hsap ------------------------------------------------------------ RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap ------------------------------------------------------------ ANKRD3_Mmus ------------------------------------------------------------ ANKRD3_Hsap ------------------------------------------------------------ RIPK1_Mmus ------------------------------------------------------------ RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus ------------------------------------------------------------ ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur ------------------------------------------------------------ ANKK3_Spur TKLGATALHCSSRNGHLDVVKYLIGQGAQIANPTKLCITALHLASDAGHRDIVEYLVRQG ANKK6_Spur ------------------------------------------------------------ ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap ------------------------------------------------------------ RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap ------------------------------------------------------------ ANKRD3_Mmus ------------------------------------------------------------ ANKRD3_Hsap ------------------------------------------------------------ RIPK1_Mmus ------------------------------------------------------------ RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus ------------------------------------------------------------ ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur ------------------------------------------------------------ ANKK3_Spur AQIDTCDIYGQTPLHFASQKGHLDVVEYLDGQGAQVKRGTNNGSTPLQVASLDGQLDVVQ ANKK6_Spur ------------------------------------------------------------ ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap ------------------------------------------------------------ RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap ------------------------------------------------------------ ANKRD3_Mmus ------------------------------------------------------------ ANKRD3_Hsap ------------------------------------------------------------ RIPK1_Mmus ------------------------------------------------------------ RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus ------------------------------------------------------------ ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur ------------------------------------------------------------ ANKK3_Spur YLVRQGAQVERSNNDGTTSLLAASRHGHLDVVKYLAGQGAKVKEGDNNGFTPLHAASTKG ANKK6_Spur ------------------------------------------------------------ ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap ------------------------------------------------------------ RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap ------------------------------------------------------------ ANKRD3_Mmus ------------------------------------------------------------ ANKRD3_Hsap ------------------------------------------------------------ RIPK1_Mmus ------------------------------------------------------------ RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus ------------------------------------------------------------ ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur ------------------------------------------------------------ ANKK3_Spur HLDLVAYLVGRGAQVERSSNYGLTSLLAASRHGHLDVVKYLVGQGAKVKEGDNNGFTPLH ANKK6_Spur ------------------------------------------------------------ ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap ------------------------------------------------------------ RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap ------------------------------------------------------------ ANKRD3_Mmus ------------------------------------------------------------ ANKRD3_Hsap ------------------------------------------------------------ RIPK1_Mmus ------------------------------------------------------------ RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus ------------------------------------------------------------ ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur ------------------------------------------------------------ ANKK3_Spur AASTKGHLDLVAYLVGRGAQVERGDNTGWTPLLSASQGGHLDVVQYLVVQGAQVERGNND ANKK6_Spur ------------------------------------------------------------ ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap ------------------------------------------------------------ RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap ------------------------------------------------------------ ANKRD3_Mmus ------------------------------------------------------------ ANKRD3_Hsap ------------------------------------------------------------ RIPK1_Mmus ------------------------------------------------------------ RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus ------------------------------------------------------------ ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur ------------------------------------------------------------ ANKK3_Spur GLTPLLAASSNGYLDVVKYLVGQGAQVERGANNGFTPLLAASSNGHLDVVKYLVGQGAKV ANKK6_Spur ------------------------------------------------------------ ank2_Spur ---------------------------------------------------YLVGQGAKV ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur -----------------------------------------------DIVEYLVGQGAQI SgK288_Hsap ------------------------------------------------------------ RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap ------------------------------------------------------------ ANKRD3_Mmus ------------------------------------------------------------ ANKRD3_Hsap ------------------------------------------------------------ RIPK1_Mmus ------------------------------------------------------------ RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus ------------------------------------------------------------ ANKK2_Spur -----------------------FEMLLGEDVQ--K------------------------ ANKK1_Spur ------------------------------------------------------------ ANKK3_Spur KEGD-NNGFTPLHAASTKGRLDVVKYLVGQGAQVERGANNGFTPLLAASSNGHLDVVKYL ANKK6_Spur ------------------------------------------------------------ ank2_Spur EKCDNNYGMTPLHAASQKGHLDVVEYLVGQGAQVEKGDNDGDTPLHCASKKGHLDVVEYL ANKK5_Spur ---N-LNGKTPLYLASHQGHLHVVKCLVNHGAHVELGNNA-------------------- ank1_Spur ---D-VDGKTPIYGASLKGRLHVVQYLVGQGALIENCDNHGDTPIHAASGNGHLAIVRYL ANKK4_Spur DTCD-IDGQTPLHSSSRNGHLDVVKYLIGQGAQIDNPIKLGATALHFASDAGHRDIVEYL SgK288_Hsap ------------------------------------------------------------ RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap ------------------------------------------------------------ ANKRD3_Mmus ------------------------------------------------------------ ANKRD3_Hsap ------------------------------------------------------------ RIPK1_Mmus ------------------------------------------------------------ RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus ------------------------------------------------------------ ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur ------------------------------------------------------------ ANKK3_Spur VGQGAKVKEGD-NNGFTPLHAASTKGRLDLVAYLVGRGAQVERGDNTGWTPLLSASQGGH ANKK6_Spur ------------------------------------------------------------ ank2_Spur VRQGAHVEKCDNNDGMTPLNAASQKGHLDVVEYLVGQRAQVERGDNKGDTPLIFASCNGH ANKK5_Spur --------------GETPLLIASRKGHLDVVQYL-------------------------- ank1_Spur VRQGAEIERT-DNAGHTPLLLATGHGHIEVVEYL-------------------------- ANKK4_Spur VGQGAQVERGT-NNGFTPLHAASTKGHLDLVAYLVGQGAQVERGDNTGWTPLLSASQGGH SgK288_Hsap ------------------------------------------------------------ RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap ------------------------------------------------------------ ANKRD3_Mmus ------------------------------------------------------------ ANKRD3_Hsap ------------------------------------------------------------ RIPK1_Mmus ------------------------------------------------------------ RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus ------------------------------------------------------------ ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur ------------------------------------------------------------ ANKK3_Spur LDVVQYLLGQGAQVKRGTNNGSTPLQVASRDGQLDVVQYLVGQGAQVERGNNDGLTPLLA ANKK6_Spur ------------------------------------------------------------ ank2_Spur LDVVQYLVGQGA---------------------------------QVEKGDNNGMTPL-- ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur LDVVKYLVGRGAQVKRGTNNGSTPLQVASRDGQLDVVQYLVGQGAQVERGNNDGLTAL-- SgK288_Hsap ------------------------------------------------------------ RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap ------------------------------------------------------------ ANKRD3_Mmus ------------------------------------------------------------ ANKRD3_Hsap ------------------------------------------------------------ RIPK1_Mmus ------------------------------------------------------------ RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus ------------------------------------------------------------ ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur ------------------------------------------------------------ ANKK3_Spur ASSNGYLDVVKYLVGQGAQVERGANNGFTPLLAASSNGHLDVVKYLVGQGAQVERGANNG ANKK6_Spur ------------------------------------------------------------ ank2_Spur -------------------------------HYASKTGHLDVVEYLVGQGAQIDTCDIDG ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur -------------------------------LAASSNGHIDVVKYLVGQGAQVERGANNG SgK288_Hsap ------------------------------------------------------------ RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap ------------------------------------------------------------ ANKRD3_Mmus ------------------------------------------------------------ ANKRD3_Hsap ------------------------------------------------------------ RIPK1_Mmus ------------------------------------------------------------ RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus ------------------------------------------------------------ ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur ------------------------------------------------------------ ANKK3_Spur LTPLLAASSNGHLDVAQYLTSKQAQRKEASPEGISTFLHINVYDVIFFFCVKFLIGQGAQ ANKK6_Spur ------------------------------------------------------------ ank2_Spur QTPLYFASHNGHLDAVKFL---QAL----------------------------------- ANKK5_Spur -------------------ESEQEQ----------------------------------- ank1_Spur -------------------EKELEQ----------------------------------- ANKK4_Spur LTPLLAALSNGHLDVAQYLTSKQAK----------------------------------- SgK288_Hsap ------------------------------------------------------------ RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap ------------------------------------------------------------ ANKRD3_Mmus ------------------------------------------------------------ ANKRD3_Hsap ------------------------------------------------------------ RIPK1_Mmus ------------------------------------------------------------ RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus ------------------------------------------------------------ ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur ------------------------------------------------------------ ANKK3_Spur IDKPTKLGAMALLFASGVGHRDVVEYLVGQGAQVERGANNGLTPLLAASSNGHLDVAQYL ANKK6_Spur ------------------------------------------------------------ ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap ---------------------------------------------LRL-GSLPVF--TRD RIPK3_Hsap -------------------------------------------------APAPLV--SIE RIPK2_Hsap --------------------------------------------------ALPTI--PYH RIPK1_Hsap --------------------------------------------------VIKMK--SS- ANKRD3_Mmus ---------------------------------------------WAL-GLLRTF--DAG ANKRD3_Hsap ---------------------------------------------WAL-ALLRTF--DAG RIPK1_Mmus --------------------------------------------------NIKMA--SS- RIPK2_Mmus --------------------------------------------------ALPPI--PYH RIPK3_Mmus ------------------------------------------------ASAVPLV--SRE SgK288_Mmus ----------------------NP--------------MAVGPLAQQL-GSLTVF--TRD ANKK2_Spur ---------------------NDPVSVHHLEVKLDQIDMVDLNVKVSSGVKFAFHEKKAR ANKK1_Spur ----------------------ARLSVH----QLDEIMMADLTVKDSTGRKCTFHEKKAR ANKK3_Spur TSKQAQRKEASPEESAGVKVPDARSSVPQPFLNLKTIVMADLTIKDSSGGKHAFHGKKAR ANKK6_Spur -----------------------------------------LTVEDSSGKTCAFHEKKAR ank2_Spur ------RKEASPEESAGV-----QVPVPQPVLNLQTIAMADLTVKDSSGGKYAFHEKKAR ANKK5_Spur ------RTNARP-----------------------EIVMADLTVTDSSGGRFPFHEKKAR ank1_Spur ------REDERAE-----------------EVILKNIVMADLTVTDSSGEQCAFHEKKAR ANKK4_Spur ------RKEASPEVS------DARSSVPQPFFNLKTIMMADLTIKDSSGGKHAFHKKKAR SgK288_Hsap DFEGDWRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPPDAASS-----DVNYLIEEA-A RIPK3_Hsap ELE-NQELVGKGGFGTVFRAQHRKWGYDVAVKIVNS--KAI-------------SREV-K RIPK2_Hsap KLA-DLRYLSRGASGTVSSARHADWRVQVAVKHLHIH-TPLLDS-----ERKDVLREA-E RIPK1_Hsap DFL-ESAELDSGGFGKVSLCFHRTQGL-MIMKTVYK--GPNCIE-----HNEALLEEA-K ANKRD3_Mmus EFA-GWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLH--VDDR-----ERMELLEEA-K ANKRD3_Hsap EFT-GWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLH--VDDR-----ERMELLEEA-K RIPK1_Mmus DLL-EKTDLDSGGFGKVSLCYHRSHGF-VILKKVYT--GPNRAE-----YNEVLLEEG-K RIPK2_Mmus KLA-DLHYLSRGASGTVSSARHADWRVRVAVKHLHIH-TPLLDS-----ERNDILREA-E RIPK3_Mmus ELK-KLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNS--KKI-------------SWEV-K SgK288_Mmus DFEEEWHLVASGGFSKVFQARHKRWRTQYAIKCSPCLQKETTSS-----EVTCLFEEA-V ANKK2_Spur ELE-G-CHLGGGSFGEVFKAVHKVHG-DVAVKLAKP--GKGDQL-------KMHQKEARK ANKK1_Spur EHE-G-CHLGGGSFGEVYKAVHKVHG-DVAVKLAKP--GKEDQV------VLMYQKEAGK ANKK3_Spur KLK-G-CHLGGGSFGEVYKATHAVHG-DVAVKLAKP--GKERQV-------EMYQKEARK ANKK6_Spur EHE-G-CHLGGGSFGEVFKATHKVHG-EVAVKLAKP--Gxxxxx------xxxxxxxxxx ank2_Spur KLE-G-CHLGGGSFGEVYKATHTVHD-DVAVKLAKP--GKEGQV-------VMYQKEARK ANKK5_Spur KLE-G-CHLGGGSFGEVFKATHAVHG-DVAVKLAKG------QV-------VMYQKEAQK ank1_Spur DHE-G-CHLGGGSFGEVFKAVHAVHG-DVAVKLAKP--GKERQLEMYKKQVVMYQKEAQK ANKK4_Spur KLE-G-CHLGGGSFGEVYKATHAVHG-DVAVKLAKP--GKEDQV-------KMYKKEARK . : *. . * * :* SgK288_Hsap KMKKIKFQHIVSIYGVCKQP---------LGIVMEFMANGSLEKVLSTH----------- RIPK3_Hsap AMASLDNEFVLRLEGVIEKVNWD-QD-PKPALVTKFMENGSLSGLLQSQ----------- RIPK2_Hsap ILHKARFSYILPILGICNEP-------EFLGIVTEYMPNGSLNELLHRKT-E-------- RIPK1_Hsap MMNRLRHSRVVKLLGVIIEE-------GKYSLVMEYMEKGNLMHVLKAEM---------- ANKRD3_Mmus KMEMAKFRYILPVYGICQEP---------VGLVMEYMETGSLEKLLASE----------- ANKRD3_Hsap KMEMAKFRYILPVYGICREP---------VGLVMEYMETGSLEKLLASE----------- RIPK1_Mmus MMHRLRHSRVVKLLGIIIEE-------GNYSLVMEYMEKGNLMHVLKTQI---------- RIPK2_Mmus ILHKARFSYILPILGICNEP-------EFLGIVTEYMPNGSLNELLHRKT-E-------- RIPK3_Mmus AMVNLRNENVLLLLGVTEDLQWD-FV-SGQALVTRFMENGSLAGLLQPE----------- SgK288_Mmus KMEKIKFQHIVSIYGVCKQP---------LGIVMEFMASGSLEKTLPTH----------- ANKK2_Spur HGLSLTCDYIVAIKGFVKCEEDTCPC-GLLGIVMQYMENGSLWDFRISEWQP-------- ANKK1_Spur HVLSLTSNHIVSIKGFVQCEKAACDCGCLIGIVMEYMKHGSLWDFRISKWQD-------- ANKK3_Spur HENSLICEHIVPIKGFVECEDDACNC-GLIGIVMKYMENGSLWDFRTTKWQQ-------- ANKK6_Spur xxxxxxxxxxxxxxxxxxxxxxxxxx-xLFGIVMKYMENGSLWDFRKRRWQD-------- ank2_Spur HENSLICEHIVPIKGFVECEDDACNC-GLIGIVMKYMENGSLWDFRTTKWLQ-------- ANKK5_Spur HENSLICEHIVSIKGFVECKDDACTC-GLIGIVMTYMENGSLWDFRTTKWLH-------- ank1_Spur HENSLKCEHIVPIKGFVQCEDKACDC-ELFGIVIQYMKNGSLWNFRTTKWRQHPDHLDFR ANKK4_Spur HENSLICEHIVPIKGFVECEDDACNC-GLIGIVMKYMENGSLWDFRTTKWQQ-------- .:* :* *.* . SgK288_Hsap -------S-LCWKLRFRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFG RIPK3_Hsap ------CPR-PWPLLCRLLKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFG RIPK2_Hsap ------YPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFG RIPK1_Hsap -------S-TPLSVKGRIILEIIEGMCYLHGK--GVIHKDLKPENILVDNDFHIKIADLG ANKRD3_Mmus -------P-LPWDLRFRIVHETAVGMNFLHCMSPPLLHLDLKPANILLDAHYHVKISDFG ANKRD3_Hsap -------P-LPWDLRFRIIHETAVGMNFLHCMAPPLLHLDLKPANILLDAHYHVKISDFG RIPK1_Mmus -------D-VPLSLKGRIIVEAIEGMCYLHDK--GVIHKDLKPENILVDRDFHIKIADLG RIPK2_Mmus ------YPDIAWPLRFRILHEIALGVNYLHNMNPPLLHHDLKTQNILLDNEFHVKIADFG RIPK3_Mmus ------CPR-PWPLLCRLLQEVVLGMCYLHSLNPPLLHRDLKPSNILLDPELHAKLADFG SgK288_Mmus -------S-LCWPLKLRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDNNMHVKISDFG ANKK2_Spur ------FPD-LWPLTNRMVYQISCGMHFLHSKN--IIHRDLKLENVLVDGDLHVKIADLG ANKK1_Spur ------RPD-LWPLTNRMVHQISSGMHFLHSKD--IIHRDLKLENVLVDGNLNVKVADLG ANKK3_Spur ------HPD-LLPLTNRMVYEMSSGMQFLHSKD--IIHRDLKLENVLVDGDLHVKIADLG ANKK6_Spur ------HPD-LWPLTNR-VYEISCGMHFLHSND--IIHRDLKLENVLVDGNLHAKIADLG ank2_Spur ------HPD-LLPLINRMVYEMSSGMQFLHSKD--IIHRDLKLENVLVDGDLHVKIADLG ANKK5_Spur ------HPD-LWPLTNRMIYQISCGMHFLHSND--IIHRDLKLENVLVDGDLNVKISDLG ank1_Spur TTKLLHHPD-LWPLTNRMVYQISRGMHFLHSKY--IIHRDLKLENVLVDRNLNVKIADLG ANKK4_Spur ------HPD-LLPLTNRMVYEMSSGMQFLHSKD--IIHRDLKLENVLVDGDLHVKIADLG : * : : .: :** ::* *** *:*:* . : *::*:* SgK288_Hsap LSKWMEQSTRMQ---------Y-IE-RSALRGMLSYIPPEMFLE----SNKAPGPKYDVY RIPK3_Hsap LSTFQGGSQSG-------------TGSGEPGGTLGYLAPELFVN----VNRKASTASDVY RIPK2_Hsap LSKWRMMSLSQS---------RSSK-SAPEGGTIIYMPPENYEP---GQKSRASIKHDIY RIPK1_Hsap LASFKMWSKLNNEEHNELRE-VDGT-AKKNGGTLYYMAPEHLND----VNAKPTEKSDVY ANKRD3_Mmus LAKCNGMSHSHD-----------LS-MDGLFGTIAYLPPERIRE----KSRLFDTKHDVY ANKRD3_Hsap LAKCNGLSHSHD-----------LS-MDGLFGTIAYLPPERIRE----KSRLFDTKHDVY RIPK1_Mmus VASFKTWSKLTKEKDNKQKEVSSTT-KKNNGGTLYYMAPEHLND----INAKPTEKSDVY RIPK2_Mmus LSKWRMMSLSQS---------RSYK-SAPEGGTIIYMPPENYEP---GQKSRASVKHDIY RIPK3_Mmus LSTFQGGSQSGS---------GSGSGSRDSGGTLAYLDPELLFD----VNLKASKASDVY SgK288_Mmus LSKWMEQSTQKQ---------Y-IE-RSALRGTLSYIPPEMFLE----NNKAPGPEYDVY ANKK2_Spur LATNLQTSS----------------G-DRCWGTDSHKPPEAFRTDLPNSTKVVTPKYDVY ANKK1_Spur LATNLQTSF----------------G-DERCGTNSHKPPEAFRTDLPNSTKVVTPEYDVY ANKK3_Spur LATNLQTSF----------------G-DRCCGTHSHKPPEAFRTDIPNSIMIGTPKYDVY ANKK6_Spur LAADLRTSF----------------G-DRCWGTDSHKPPEAFRTDLSKSIKVVNPKYDVY ank2_Spur LATNLQTSF----------------G-DRCWGTDSHKPPEAFRTDLPNSTKIVTPKYDVY ANKK5_Spur LATNLQTSF----------------G-DRCWGTDSHKPPEAFRTDLPDSTKVVTPKYDVY ank1_Spur LATNLQTSS----------------G-KGCYGTDSHKPPEAFRTDIPNSTKVVTPKYDVY ANKK4_Spur LATNLQTSF----------------G-DRCCGTHSHKPPEAFRTDIPNSIMIGTPKYDVY :: * * : ** *:* SgK288_Hsap S-FAIVI---WELLTQKKPYSGF-NMMMIIIRVAAGMRPSLQP--VSDQWPSE--AQQMV RIPK3_Hsap S-FGILM---WAVLAGREVELPTEPSLVYEAVCNRQNRPSLAE--LPQAGPETPGLEGLK RIPK2_Hsap S-YAVIT---WEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHR---ARMI RIPK1_Hsap S-FAVVL---WAIFANKEPYENAICEQQLIMCIKSGNRPDVDD--ITEYCPR-----EII ANKRD3_Mmus S-FAIVI---WGVLTQKKPFADEKNILHIMMKVVKGHRPELPP--ICRPRPRA--CASLI ANKRD3_Hsap S-FAIVI---WGVLTQKKPFADEKNILHIMVKVVKGHRPELPP--VCRARPRA--CSHLI RIPK1_Mmus S-FGIVL---WAIFAKKEPYENVICTEQFVICIKSGNRPNVEE--ILEYCPR-----EII RIPK2_Mmus S-YAVIM---WEVLSRKQPFEEVTNPLQIMYSVSQGHRPDTSEENLPFDIPHR---GLMI RIPK3_Mmus S-FGILV---WAVLAGREAELVDKTSLIRETVCDRQSRPPLTE--LPPGSPETPGLEKLK SgK288_Mmus S-FAIVI---WEILTQKKPYAGL-NMMTIIIRVAAGMRPSLQD--VSDEWPEE--VHQMV ANKK2_Spur S-FAMTL---YELLTGIHPYSDRGFDMMKLLKVEAKQPPCLQP--VPVNAPK-----DLI ANKK1_Spur S-FAMTL---YELLTGIHPYSDRGFYMMMLLKVDSKQSPCLQP--IPASTPE-----DLI ANKK3_Spur R-KASEKDTHNEA----------------------------------------------- ANKK6_Spur S-FAMTL---YELLTGIHPYAERGLEMVKVFKL-SDQAPCLKP--VPVNTPT-----PLI ank2_Spur ------------------------------------------------------------ ANKK5_Spur REFEFVK---QQK-------------------VD-NTTPCEDP--VPENTPE-----ALI ank1_Spur ------------------------------------------------------------ ANKK4_Spur S-FAMTL---YEL----------------------------------------------- SgK288_Hsap DLMKRCWDQDPKKRPCFLDITIETDILL-SLLQSRVA-VPESKALARKVSCK-------- RIPK3_Hsap ELMQLCWSSEPKDRPSFQECLPKTDEVF-QMVENNM-NAAVST-VK-DFLSQLRSSNRRF RIPK2_Hsap SLIESGWAQNPDERPSFLKCLIELEPVL-RTFEEITFLEAVIQ-LK-KTKLQSVSSAIHL RIPK1_Hsap SLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESV-EEDVKS-LK-KEYSNENAVVKRM ANKRD3_Mmus GLMQRCWHADPQVRPTFQEITSETEDLC-EKPDEEVK-DLAHE-PGEKSSLESKSEARPE ANKRD3_Hsap RLMQRCWQGDPRVRPTFQEITSETEDLC-EKPDDEVK-ETAHD-LDVKSPPEPRSEVVP- RIPK1_Mmus SLMERCWQAIPEDRPTFLGIEEEFRPFYLSHFEEYV-EEDVAS-LK-KEYPDQSPVLQRM RIPK2_Mmus SLIQSGWAQNPDERPSFLKCLIELEPVL-RTFEDITFLEAVIQ-LK-KAKIQSSSSTIHL RIPK3_Mmus ELMIHCWGSQSENRPSFQDCEPKTNEVY-NLVKDKV-DAAVSE-VK-HYLSQHRSSGRNL SgK288_Mmus NLMKRCWDQDPKKRPCFLNVAVETDMLL-SLFQSPMT-DPGCEALTQKVSCK-------- ANKK2_Spur EVMQECWSYEANERPNFREIRDRVKNLG-TEP---T-Y---AS-LG-FYLGEQVVPELI- ANKK1_Spur RVMEESWSYEPNDRPNFREITEWVANLD-TEP---T-H---ES-LG-HYLGEQRSPENVG ANKK3_Spur ----------------FNVINIF------------------------------------- ANKK6_Spur KVMTDSWRYAANSRPAFIEITDWVKNQLNIKP---T-H---RS-LG-ICLGEVTRAQLQ- ank2_Spur ------------------------------------------------------------ ANKK5_Spur EVMRDSWSYEANDRPNFGALLHS------------------------------------- ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap ------------------------------------------------------------ RIPK3_Hsap -SI-PESGQGG------------------------------------------------- RIPK2_Hsap C-D-K-----------------------------KKMELSLN------------------ RIPK1_Hsap QSL-QL----DCVAVPS--------S-RSNSATEQPGSLHSSQGLGMGP----------- ANKRD3_Mmus S-S-RL----KRASAPPFD-----ND-CSLS--ELLSQLDSG------------------ ANKRD3_Hsap --A-RL----KRASAPTFD-----ND-YSLS--ELLSQLDSG------------------ RIPK1_Mmus FSL-QH----DCVPLPP--------S-RSNS--EQPGSLHSSQGLQMGP----------- RIPK2_Mmus C-D-K------------------------------KMDLSLN------------------ RIPK3_Mmus -SA-REPSQRG------------------------------------------------- SgK288_Mmus ------------------------------------------------------------ ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur -RADDEPVRRGMQDLPVNDPTPVEQS-NGN--AAIPITETETQNQQNSPENVGR------ ANKK3_Spur ------------------------------------------------------------ ANKK6_Spur --ESQDLAQRCMAS----TKTLTERATQQE--AQLLILEEETEKVKNQCSNLKKTVQNLE ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap ----------------------------------LSLRQPGE------------------ RIPK3_Hsap ---------------------------TEMD----------------------------- RIPK2_Hsap ---------------------------------IPVNHGPQE------------------ RIPK1_Hsap ---------------------------VEESWFAPSLEHPQE------------------ ANKRD3_Mmus --------------------------------ISQTLEGPEE------------------ ANKRD3_Hsap --------------------------------VSQAVEGPEE------------------ RIPK1_Mmus ---------------------------VEESWFSSSPEYPQD------------------ RIPK2_Mmus ---------------------------------IPANHPPQE------------------ RIPK3_Mmus ---------------------------T-------------------------------- SgK288_Mmus ----------------------------------PSLSQPHK------------------ ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur -------ADHEPVRRGMQDLPINDPTPVEQSN--GNAAIPITETETQNQVEGHESPPTHP ANKK3_Spur ------------------------------------------------------------ ANKK6_Spur DINTSWASKNQAMKKDMQDLKMELDTQSAE-L--DQLKLPICKCDRDTQTRSSTNSDNCY ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap -VNEDIS--QE-LMDSDSGNYLK------------R-ALQLSD----------------- RIPK3_Hsap ----------------GFRRTIENQHSRNDVMVSEW-LNKLNL----------------- RIPK2_Hsap -ESCGSS--QLHE-NSGS------------------------------------------ RIPK1_Hsap -ENEPSL--QSKLQDE-ANYHLYG-SRMDR------------------------------ ANKRD3_Mmus -LSRSSS--ECKLPSSSSGKRLSGVSSVDSAFSSRG-SLSLSFERE-------------- ANKRD3_Hsap -LSRSSS--ESKLPSSGSGKRLSGVSSVDSAFSSRG-SLSLSFERE-------------- RIPK1_Mmus -ENDRSV--QAKLQEE-ASYHAFG-IFAEK------------------------------ RIPK2_Mmus -ESCGSS--LLSR-NTGS------------------------------------------ RIPK3_Mmus --------------------EMDCPR---ETMVSKM-LDRLHL----------------- SgK288_Mmus -VSKEVN--QE-IADSVSSDSLK------------W-ILQLSD----------------- ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur IIQRSSSKKEGLPPNFGHQRSPENVGRADDEPVRRG-MQDLPVNDPTPVEQSNGNA-AIP ANKK3_Spur ------------------------------------------------------------ ANKK6_Spur ASTTMTDRNECASILAVEELTPESVKVEDTQTVRQSKTQDFQVEGQQEVHQGEERNSLI- ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap ------------------------------------------------------------ RIPK3_Hsap ------------------------------------------------------EEP--P RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap ------------------------------------------------------------ ANKRD3_Mmus ----------ASTGDL-----------------GP------------------------- ANKRD3_Hsap ----------PSTSDL-----------------GT------------------------- RIPK1_Mmus ------------------------------------------------------------ RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus ------------------------------------------------------EEP--S SgK288_Mmus ------------------------------------------------------------ ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur ITE--------------------------------------------------------- ANKK3_Spur ------------------------------------------------------------ ANKK6_Spur -QEADTAHATPSTSARGNLQETMVCSLKDETARGTRDHMNEQRTEEQSLDNFKDNIPIED ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap ------------------------------------------------------------ RIPK3_Hsap SSVPKKCPSLTKRSRAQE------------------------------------------ RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap ------------------------------------------------------------ ANKRD3_Mmus -------------TDIQK-------------------KKLVDAIISGDTSR--------- ANKRD3_Hsap -------------TDVQK-------------------KKLVDAIVSGDTSK--------- RIPK1_Mmus ------------------------------------------------------------ RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus GPVPGKCPERQ----AQD------------------------------------------ SgK288_Mmus ------------------------------------------------------------ ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur ------------------------------------------------------------ ANKK3_Spur ------------------------------------------------------------ ANKK6_Spur LPVEVAIVAEQ----IQKCKGEGDTLQDVSAGEEISQNQLRSIVVTGPSNMPGHSSDELS ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap ---RKNLV-------------------------------------PRDEELCIYENKVTP RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap ---QTKQQ-------------------------------------PRQN----------- ANKRD3_Mmus --LMKILQ-------------------------------------PQDVDL-VLDSSASL ANKRD3_Hsap --LMKILQ-------------------------------------PQDVDL-ALDSGASL RIPK1_Mmus ---QTKPQ-------------------------------------PRQN----------- RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus ---SKSLV-------------------------------------ASD----VYENRVTP ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur ------------------------------------------------------------ ANKK3_Spur ------------------------------------------------------------ ANKK6_Spur LNHQKDTQPKRVGTGQSADAFDTLTTTLTTLNTISLKTYSGSLEVPAKANY-ITTSQ--- ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap LHFLVA----------QG----------SVEQVRLLLAHEVDVD-CQTASGYTPLLIAAQ RIPK3_Hsap ----------------------------------------------------EQVPQ--- RIPK2_Hsap -------------------------------------------P-ETSRSLPAPQDNDFL RIPK1_Hsap ----------------------------------------------------VAYNREEE ANKRD3_Mmus LHLAVE----------AG----------QEECVKWLLLNNANPN-LTNRKGSTPLHMAVE ANKRD3_Hsap LHLAVE----------AG----------QEECAKWLLLNNANPN-LSNRRGSTPLHMAVE RIPK1_Mmus ----------------------------------------------------EAYNREEE RIPK2_Mmus -------------------------------------------P-GPSRSLSAPQDKGFL RIPK3_Mmus ----------------------------------------------------TSVGP--- SgK288_Mmus LHFLVA----------GG----------SLEQVRLLLSHDVDVD-CQTASGYTPLLIATQ ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur ---------------------------------------TETQ-NQVEGHESPPTHPIIQ ANKK3_Spur ------------------------------------------------------------ ANKK6_Spur -----ARLGNQQLPAELGNNPGRIIPLDKEETSPPVQESKTSPETYTDNEPDACVGKAEE ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap DQ-------------QPDLCALLLA------HGADAN--RVDEDGWAPLHFAA-QNGDD- RIPK3_Hsap --------------------------------------------AW-------------- RIPK2_Hsap SR-------------KAQDCYFMKL------HHCPGN--HS-WDSTISGS---------- RIPK1_Hsap RR-------------R-RVSHDPFA------QQRPYENFQNTEGKGTAYSSAA-SHGNAV ANKRD3_Mmus RK-------------GRGIVELLLA------RKTSVN--AKDEDQWTALHFAA-QNGDE- ANKRD3_Hsap RR-------------VRGVVELLLA------RKISVN--AKDEDQWTALHFAA-QNGDE- RIPK1_Mmus RK-------------R-RVSHDPFA------QQRARENIKSAGARGHSDPSTT-SRGIAV RIPK2_Mmus SG-------------APQDCSSLKA------HHCPGN--HS-WDGIVSVP---------- RIPK3_Mmus --------------------------------------------AT-------------- SgK288_Mmus DQ-------------QPDLCALLLA------HGADTN--LADEDGWAPLHFAA-QNGDD- ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur RSSTKKEGKKDDKSVGRGMKNLTLQEQARARHQSNTN--AAVHDIQTVIHDESVRKGM-- ANKK3_Spur ------------------------------------------------------------ ANKK6_Spur AR-------------SHSVVLDVFG------NQNQVD--AYDEDIVIPRTYVE-ENS--- ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap -------------------GTARLLLDHGACVDAQEREGW--TPLH---LAAQNNFE-NV RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap HQPSGLT------------SQPQVLYQNNGLYSSHGF----------------------- ANKRD3_Mmus -------------------ASTRLLLEKNASVNEVDFEGR--TPMH---VACQHGQE-NI ANKRD3_Hsap -------------------SSTRLLLEKNASVNEVDFEGR--TPMH---VACQHGQE-NI RIPK1_Mmus QQLSWP--------------ATQTVW-NNGLYNQHGF----------------------- RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus -------------------HTARLLLDHGALVNAREHEGW--TPLH---LAAQNNFE-NV ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur ------EGLTMNDHTPVEQSNGKTAIPINETVTQHQVEGQESPPTH-------LGQD-NV ANKK3_Spur ------------------------------------------------------------ ANKK6_Spur ---------------------SRCRGEEKGELQ-------EREPVECDSVA--HAHEANV ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap A---------RLLVSRQADPNL-----------------------------HEAEGKTP- RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap -------------GTRPLDPGT-----------------------------AGPRVWYR- ANKRD3_Mmus V---------RTLLRRGVDVGL-----------------------------QGKDAWLP- ANKRD3_Hsap V---------RILLRRGVDVSL-----------------------------QGKDAWLP- RIPK1_Mmus --------------------GT-----------------------------TGTGVWYP- RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus A---------RLLVSRQADLSP-----------------------------HEAEGKTP- ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur V---------APLEIQHSQPSSQDPSKPSSFGRLKSQISGPQYRCHGDIFQPTVEAEQPM ANKK3_Spur ------------------------------------------------------------ ANKK6_Spur FHEVGKDRLPGGAGTRQGEIGLSL-----------------------------ESGQVSL ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap ------------------------------------------------------------ RIPK3_Hsap --------TAGTSSD---------------------------------------SMAQPP RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap ------------------------------------------------------------ ANKRD3_Mmus ------------------------------------------------------------ ANKRD3_Hsap ------------------------------------------------------------ RIPK1_Mmus ------------------------------------------------------------ RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus --------PARTSSD---------------------------------------PVAGTP SgK288_Mmus ------------------------------------------------------------ ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur EFTGFVSAPTENSPD---------------------------------------P----- ANKK3_Spur ------------------------------------------------------------ ANKK6_Spur K------------SDNIEASKTLPVFILSTETIPGNSKFIPTSKLMGISVTSEEP----- ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap ------------------------------------------------------------ RIPK3_Hsap QTP----------ETSTFRNQMPSPTSTGTPSPGPR------------------------ RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap ------------------------------------------------------------ ANKRD3_Mmus ------------------------------------------------------------ ANKRD3_Hsap ------------------------------------------------------------ RIPK1_Mmus ------------------------------------------------------------ RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus QIP----------HTLPFRGTTPGPVFTETPGPHPQ------------------------ SgK288_Mmus ------------------------------------------------------------ ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur SASQPLKSYRKAEQPTEFTGFVSAPTE-NSPGP------SESQPLKSYREAE-------- ANKK3_Spur ------------------------------------------------------------ ANKK6_Spur STP----------KDISKRGTLAKSALSETDGT--ETLPQE----------ENGPQDINS ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap ------------------------------------------------------------ RIPK3_Hsap -------------------------------------------------------GNQGA RIPK2_Hsap ------------------------------------------------------------ RIPK1_Hsap -----------------------------------------------------PIPSHMP ANKRD3_Mmus ------------------------------------------------------------ ANKRD3_Hsap ------------------------------------------------------------ RIPK1_Mmus -----------------------------------------------------PNLSQMY RIPK2_Mmus ------------------------------------------------------------ RIPK3_Mmus -------------------------------------------------------RNQGD SgK288_Mmus ------------------------------------------------------------ ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur ------------QPMEFTGFVS-----------------ASTENSPDPSESQPLK----- ANKK3_Spur ------------------------------------------------------------ ANKK6_Spur SQSCYDSTDRKERPLSATNLCEPGNYNILRKKGESSPLTTK------PTFFQTPKRKHAP ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap ------LHVAAYF-----------GHVSLVKLLTSQ-GA------ELD------------ RIPK3_Hsap ERQGMN-----WS-----------CRTPEPNPVTGRPL---------------------- RIPK2_Hsap ------------------------------------QRA------AF------------- RIPK1_Hsap SLHNIPVPETNYL-----------GNTPTMPFSSLPPTD------ESI------------ ANKRD3_Mmus ------LHYAAWQ-----------GHLPIVKLLAKQPGV------SVN------------ ANKRD3_Hsap ------LHYAAWQ-----------GHLPIVKLLAKQPGV------SVN------------ RIPK1_Mmus STYKTPVPETNIP-----------GSTPTMPYFSGPVAD------DLI------------ RIPK2_Mmus ------------------------------------PGA------AF------------- RIPK3_Mmus GRHGTP-----WY-----------PWTP-PNPMTGPPA---------------------- SgK288_Mmus ------LHVAAYF-----------GHIGLVKLLSGQ-GA------ELD------------ ANKK2_Spur -----------------------------------TPGI------TSGL----------- ANKK1_Spur ------------SYRKAEQPMEFTGFVS--APTENSPGL------SASQPLKSYREAEQP ANKK3_Spur ------------------------------------------------------------ ANKK6_Spur SLHQVS-----SP-----------PFVP--KPPTFVPDISAFSYMSNSEPLSSLRNIDDR ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap -AQQRNL------RTPLHLAVERGKVRAIQHLLKS----------GA-V---PDA----- RIPK3_Hsap ------------------------------VNIYN----------CS-G---VQV----- RIPK2_Hsap ---------------------------------------------CDHK---TTP----- RIPK1_Hsap -KYTIYN------STG----IQIGAYNYMEIGGTSSSLLDSTNTNFKEE---PAA----- ANKRD3_Mmus -AQTLDG------RTPLHLAAQRGHYRVARILIDL----------CS-D---VNI----- ANKRD3_Hsap -AQTLDG------RTPLHLAAQRGHYRVARILIDL----------CS-D---VNV----- RIPK1_Mmus -KYTIFN------SSG----IQIGNHNYMDVGLNSQ----PPNNTCKEE---STS----- RIPK2_Mmus ---------------------------------------------CDRR---ASS----- RIPK3_Mmus ------------------------------LVFNN----------CS-E---VQI----- SgK288_Mmus -AQQRNL------RTPLHLAVERGKVRAIQHLLKC----------GA-L---PDA----- ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur MEFTGFVSAPTENSPGLSESQPLKSYREAEQLMEF----------TG-F---VSAPTENS ANKK3_Spur ------------------------------------------------------------ ANKK6_Spur QKHPLAKTKSTWSSPSVKKSSE--------------------------FGSAKSYSSWKT ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap -------------------------------LDQSGYGPLHTAAAR-GKYL---IC---- RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap -------------------------------CSSAIINPLSTAGNS-ERLQ---PG---- RIPK1_Hsap -------------------------------KYQAIFDN-TTSLTD-KHLDPIREN---- ANKRD3_Mmus -------------------------------CSLQAQTPLHVAAET-GHTS---TA---- ANKRD3_Hsap -------------------------------CSLLAQTPLHVAAET-GHTS---TA---- RIPK1_Mmus -------------------------------RHQAIFDN-TTSLTD-EHLNPIREN---- RIPK2_Mmus -------------------------------CSLAVISPFLVEKGS-ERPP---IG---- RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus -------------------------------LDHSGYSPLHIAAAR-GKDL---IF---- ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur PDPSESQPLKSYREDGKPVPVESSHGNTEYAVAHTAGGPIHQESPVVAPSQPSSTERDPT ANKK3_Spur ------------------------------------------------------------ ANKK6_Spur LDQLRMQPHQHQSNQTTRMPVR-------------------------------------- ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap -------------------------------------------KMLLRYGASLELP---- RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap -------------------------------------------IAQQWIQSKREDI---- RIPK1_Hsap -------------------------------------------LGKHWKNCARKL----- ANKRD3_Mmus -------------------------------------------RLLLHRGAGKEAL---- ANKRD3_Hsap -------------------------------------------RLLLHRGAGKEAM---- RIPK1_Mmus -------------------------------------------LGRQWKNCARKL----- RIPK2_Mmus -------------------------------------------IAQQWIQSKREAI---- RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus -------------------------------------------KMLLRYGASLELR---- ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur IIFDSSQPSDEDFEIKVKVRLNIQLRASMASKLDQIFICLERCKHRDYWDSNSSLSTMFS ANKK3_Spur ------------------------------------------------------------ ANKK6_Spur --FSHLPPSAQQLHQSL------------------------------------------- ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap ---------------------------THQGWTPL-------HLAAYKGHLEI------- RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap ---------------------------VNQ-MTEA-------CLNQSLDALLS------- RIPK1_Hsap ------------------------------GFTQS-------QIDE-IDHDYE------- ANKRD3_Mmus ---------------------------TSEGYTAL-------HLAAQNGHLAT------- ANKRD3_Hsap ---------------------------TSDGYTAL-------HLAARNGHLAT------- RIPK1_Mmus ------------------------------GFTES-------QIDE-IDHDYE------- RIPK2_Mmus ---------------------------VSQ-MTEA-------CLNQSLDALLS------- RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus ---------------------------TQQGWTPL-------HLATYKGHLEI------- ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur WIDITLKSLQLPATVDDDDFTLYFRVCNKRDLDKL-------HKLSEKGHLRQSLYYFFV ANKK3_Spur ------------------------------------------------------------ ANKK6_Spur ----------------------------------CHTTSSPTLTSSPTIHHPTS------ ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap ------IHLLA----------------------ESHANM-------------------GA RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap ------RDLIM----------------------KEDYEL-------------------VS RIPK1_Hsap ------RDGLK----------------------EK------------------------- ANKRD3_Mmus ------VKLLI----------------------EEKADV-------------------MA ANKRD3_Hsap ------VKLLV----------------------EEKADV-------------------LA RIPK1_Mmus ------RDGLK----------------------EK------------------------- RIPK2_Mmus ------RDLIM----------------------KEDYEL-------------------IS RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus ------IHQLA----------------------KSHVDL-------------------DA ANKK2_Spur ------------------------------------------------------------ ANKK1_Spur DVHLKEVCLPAEPDLKVESWEEQFNKGMAHFQKKEKANESMKSDSERSEPREKQQNETKS ANKK3_Spur ------------------------------------------------------------ ANKK6_Spur ------------------------------------------------------------ ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap LGAVNWTPLHLAARHGEEAVVSALLQCGADPNA---------------------AEQSGW RIPK3_Hsap ------------------------------------------------------------ RIPK2_Hsap TKPTRTSKV------------R-----QL-LDT---------------------TDIQGE RIPK1_Hsap --------------------VYQMLQ-KW-VMR---------------------EGIKGA ANKRD3_Mmus RGPLNQTALHLAAARGHSEVVEELVSADL-IDL---------------------SDEQGL ANKRD3_Hsap RGPLNQTALHLAAAHGHSEVVEELVSADV-IDL---------------------FDEQGL RIPK1_Mmus --------------------VYQMLQ-KW-LMR---------------------EGTKGA RIPK2_Mmus TKPTRTSKV------------R-----QL-LDT---------------------SDIQGE RIPK3_Mmus ------------------------------------------------------------ SgK288_Mmus LGSMQWTPLHLAAFQGEEGVMLALLQCGANPNA---------------------AEQSGW ANKK2_Spur -------------------------------------------------------QQSGE ANKK1_Spur GASFSQTNCSGATQINTGKVTINMKSA-KNFVVGDQHITHNYFHGSKGAEAGAGGHSSGR ANKK3_Spur ------------------------------------------------------------ ANKK6_Spur ----------------------NLT-----------------------------AQQSTD ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap TPLH------------LAV--------------------QRSTFLSVINLLEHHANVHAR RIPK3_Hsap -------------------GDNNYLTM-QQTTAL-----------PTWGLAP------SG RIPK2_Hsap EF-----------------------------------------AKVIVQKLKDNKQMGLQ RIPK1_Hsap TV-----------------------------------------GK-LAQALHQCSRIDL- ANKRD3_Mmus SALH------------LAA--------------------QGRHSQTVETLLKHGAHINLQ ANKRD3_Hsap SALH------------LAA--------------------QGRHAQTVETLLRHGAHINLQ RIPK1_Mmus TV-----------------------------------------GK-LAQALHQCCRIDL- RIPK2_Mmus EF-----------------------------------------AKVVVQKLKDNKQLGLQ RIPK3_Mmus -------------------GNYNSLVAPPRTTA--------------------------- SgK288_Mmus TPLH------------LAV--------------------HKGTFLGITHLLEYGADIHAC ANKK2_Spur IPRL------------GNLQ---------RES---------------------------- ANKK1_Spur QPQMKKQEKTKLCESREKVS---------QQTLL-----------GIEQLIPGKAVKSLG ANKK3_Spur ------------------------------------------------------------ ANKK6_Spur PPRP------------LGLS---------EDSILETSTTRAKEIHSVMPRLTHGR----- ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap NKVGWTPAHLAAL----KGNT-------AILKVLVEAG-AQL-----DV-QDGVSCTPLQ RIPK3_Hsap KGRG------------------------------LQHP-PPVGSQEGPKDPEAW-S---- RIPK2_Hsap P-----------Y-----------------P---------EI------L-VVSRS-PSLN RIPK1_Hsap ---------------------------------------------------------LSS ANKRD3_Mmus S-----------L----------------------------------KF-QGGQS-SAAT ANKRD3_Hsap S-----------L----------------------------------KF-QGGHG-PAAT RIPK1_Mmus ---------------------------------------------------------LNH RIPK2_Mmus P-----------Y-----------------P---------EV------P-VLSKA-PPSN RIPK3_Mmus -------------------------------------------SSSAKYDQAQF-G---- SgK288_Mmus NKVGWTPAHLAAL----KGNT-------AILKVLVKAA-AQV-----DV-KGGVSCTPLQ ANKK2_Spur ----------------------------------------KFDLT----------MVPEL ANKK1_Spur RHLGLDHVRIENI----VYENQNETSSEIAYQL-LREWIQQNGHQ----------ATKAV ANKK3_Spur ------------------------------------------------------------ ANKK6_Spur ------SI-IDSSSGRDDHSHFQEKISSTTKQV-TES-NPT--SP----------KYPPV ank2_Spur ------------------------------------------------------------ ANKK5_Spur ------------------------------------------------------------ ank1_Spur ------------------------------------------------------------ ANKK4_Spur ------------------------------------------------------------ SgK288_Hsap L-ALRSRKQGIMSFL--EG-KEPSVATLGGS---------------------K------- RIPK3_Hsap --------------------------------------------------------RPQG RIPK2_Hsap L----------------------------------------------------------- RIPK1_Hsap L----------------------------------------------------------- ANKRD3_Mmus L----------------------------------------------------------- ANKRD3_Hsap L----------------------------------------------------------- RIPK1_Mmus L----------------------------------------------------------- RIPK2_Mmus F----------------------------------------------------------- RIPK3_Mmus --------------------------------------------------------RGRG SgK288_Mmus L----------------------------------------------------------- ANKK2_Spur ---------------------------------------------------------ITL ANKK1_Spur L---AN------------------------ALWK----------------------AECC ANKK3_Spur ----------------------------------------------------------FG ANKK6_Spur PVNLATRRLPPRSDQDREGAAGDAGGDASLFSDDECEEDMKDGVASQIDRIQNFLKKDRL ank2_Spur ------------------------------------------------------------ ANKK5_Spur ----------------------------------------------------------ES ank1_Spur ------------------------------------------------------------ ANKK4_Spur -----------------------------------------------------------L SgK288_Hsap PGAEMEI RIPK3_Hsap WYNHSGK RIPK2_Hsap -LQNKSM RIPK1_Hsap -IYVSQN ANKRD3_Mmus -LRRSKT ANKRD3_Hsap -LRRSKT RIPK1_Mmus -IRASQS RIPK2_Mmus -PQNKSL RIPK3_Mmus -WQPFHK SgK288_Mmus -AIHSPK ANKK2_Spur GITSAEQ ANKK1_Spur EAAESVW ANKK3_Spur SDVKLAA ANKK6_Spur RKRAKLE ank2_Spur ------R ANKK5_Spur LTFSYFV ank1_Spur ------R ANKK4_Spur TGIHPYS