CLUSTAL W (1.83) multiple sequence alignment ROR2_Hsap MARGSAL--------------------PRRPLL--------------------------- ROR1_Hsap MHRPRRR--------------------GTRPPL--------------------------- Ror_Dmel MNKYSAF--------------------I-------------------------------- cam-1_Cele MSPRP------------------------------------------------------- ROR1_Mmus MHRPRRR--------------------GTRPPP--------------------------- ROR2_Mmus MARGWVR--------------------PSRVPL--------------------------- ROR_Spur MEITGIYRWIIAHLLLVHTFYPHVLSDSTTPPPGTPYIAIDAPMNNETVIPGDSVTLNCR * ROR2_Hsap ------------------------------------------------------------ ROR1_Hsap ------------------------------------------------------------ Ror_Dmel ------------------------------------------------------------ cam-1_Cele ------------------------------------------------------------ ROR1_Mmus ------------------------------------------------------------ ROR2_Mmus ------------------------------------------------------------ ROR_Spur IRGYPKPTYWWYRNDAIIRDDIGRNVVREFKGGSTLTINNVGTLDTGSYKCIAANDNGTK ROR2_Hsap -----------------------------------------CIPAVWAAAA--------- ROR1_Hsap ---------------------------------------------LALLAA--------- Ror_Dmel ----------------------------------------------VCISL--------- cam-1_Cele ------------------------------------------------------------ ROR1_Mmus ---------------------------------------------LALLAA--------- ROR2_Mmus -----------------------------------------CARAVWTAAA--------- ROR_Spur SVQGSITLNANSPTYSESSVSDYLDEMSVDEPQCEPYRGSVCSPHIANSQVYIPAGQTQA ROR2_Hsap ---------------------------------------------------------LLL ROR1_Hsap ---------------------------------------------------------LLL Ror_Dmel ---------------------------------------------------------VLL cam-1_Cele ------------------------------------------------------------ ROR1_Mmus ---------------------------------------------------------LLL ROR2_Mmus ---------------------------------------------------------LLL ROR_Spur DIEAALGAAIQQINNDLPITLNQRCTKYLKPSMCLTAFPLCRERPRLAVHRMCYDECRLL ROR2_Hsap SVSRTSGEVEVLDPNDPLGPLDG----QDGPIP--------------------------- ROR1_Hsap AARGAAAQETELSVSAELVPTSS----WNISSE--------------------------- Ror_Dmel F----------------------------------------------------------- cam-1_Cele -----EDDDLVIEPADDEGLHYG----NASMEG--------------------------- ROR1_Mmus AARGADAQETELSVSAELVPTSS----WNTSSE--------------------------- ROR2_Mmus WTPWTAGEVEDSEAIDTLGQPDG----PDSPLP--------------------------- ROR_Spur TTEICSSLVDYVDAQPELGLVDMLPICTDLPLPGAVAGANSENSCLRMGMSESGVATITP ROR2_Hsap ---TLKGYFLNFLEPVNNITI-VQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEP--RRI ROR1_Hsap ---LNKDSYLTLDEPMNNITT-SLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEP--RRL Ror_Dmel ------------------------------------------------------------ cam-1_Cele -TSTGQRPYIRLTSQLRNATK-SSGDEVRFKCEALGTPPLKFIWLKNNGPV-EKT--KRV ROR1_Mmus ---IDKGSYLTLDEPMNNITT-SLGQTAELHCKVSGNPPPSIRWFKNDAPVVQEP--RRI ROR2_Mmus ---TLKGYFLNFLEPVNNITI-VQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEP--RRV ROR_Spur FGVPTARYFIIMERPMNNETELHTGDKATLRCRIIGDPTPHYKWYKNDALLTEERRDRRI ROR2_Hsap IIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGP-----------TH ROR1_Hsap SFRSTIYGSRLRIRNLDTTDTGYFQCVATNGKEVVSSTGVLFVKFGP-----------PP Ror_Dmel --TKKDVGS----HNVD------------------------------------------- cam-1_Cele KIRDKENSSRLVITQLDVLDSGYYQCIVSNPAASVNTTSVLRVNNVPDAVKLSQKKGSHH ROR1_Mmus SFRATNYGSRLRIRNLDTTDTGYFQCVATNGKKVVSTTGVLFVKFGP-----------PP ROR2_Mmus IIRKTEYGSRLRIQDLDTTDTGYYQCVATNGLKTITATGVLYVRLGP-----------TH ROR_Spur TTKEYEWGSKLSIRNVDTTDTGYYKCVAENRAGVRSTMGILFARIAS-----------ET .* ::* ROR2_Hsap SPNHNFQDDYH---------------------------------------------EDGF ROR1_Hsap TASPGYSDEYE---------------------------------------------EDGF Ror_Dmel ---SRIYGFQQ---------------------------------------------SSGI cam-1_Cele STKHIAFDEYEDYEMMDRGRLPDEEDADLYRVPDSAAGSNYAPVAVSERWLDGIKYRVGD ROR1_Mmus TASPGSSDEYE---------------------------------------------EDGF ROR2_Mmus SPNHNFQDDDQ---------------------------------------------EDGF ROR_Spur T-RPV--AAIP---------------------------------------------SQGY * ROR2_Hsap CQPYRGIACARFIGNRTIYVD--SLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSF ROR1_Hsap CQPYRGIACARFIGNRTVYME--SLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSL Ror_Dmel CHIYNGTICRDVLSNAHVFVS--PNLTMNDLEERLKAAYGVIKESKDMNANCRMYALPSL cam-1_Cele CVQYRGEACRQYLSNKFVMMTNESREEMYDIDRNLRAAMLFINGAPTISQKCRQLSQAVA ROR1_Mmus CQPYRGIACARFIGNRTVYME--SLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSL ROR2_Mmus CQPYRGIACARFIGNRTIYVD--SLQMQGEIENRITAAFTMIGTSTQLSDQCSQFAIPSF ROR_Spur CQPYRGMTCSNFISNHSIYVT--DFQAQKLIDERLTQAFLLM--ARDLSPQCQQYAIPSL * *.* * :.* : : ::..: * .: : :. :* : . ROR2_Hsap CHFVFPLCDARS------------------------------------------------ ROR1_Hsap CHYAFPYCDETS------------------------------------------------ Ror_Dmel CFSSMPICRTPERTNLLYFANVATNAKQLKNVSIRRKRTKSKDIKNISIFKKKSTIYEDV cam-1_Cele CHHMYKVCESDS------------------------------------------------ ROR1_Mmus CHYAFPYCDETS------------------------------------------------ ROR2_Mmus CHFVFPLCDARS------------------------------------------------ ROR_Spur CFFAFPFCDETR------------------------------------------------ *. * ROR2_Hsap -------------RTPKPRELCRDECEVLESDLCRQEYTIARSNPLILM--RLQLPKCEA ROR1_Hsap -------------SVPKPRDLCRDECEILENVLCQTEYIFARSNPMILM--RLKLPNCED Ror_Dmel FSTDISSKYPPTRESENLKRICREECELLENELCQKEYAIAKRHPVIGM---VGVEDCQK cam-1_Cele -------------N-NQIVSICKHDCDVIQNDECPSELALAAQHELVGDTPKALFPLCSR ROR1_Mmus -------------SVPKPRDLCRDECEVLENVLCQTEYIFARSNPMILM--RLKLPNCED ROR2_Mmus -------------RAPKPRELCRDECEVLENDLCRQEYTIARSNPLILM--RLQLPKCEA ROR_Spur -------------QEPRGRELCRDECEILEQDICKTEYQIAKEMPNVI------LPDCSR . :*:.:*::::. * * :* : . *. ROR2_Hsap LPMPESPDAANCMRIGIPA------ERLG---RYHQCYNGSGMDYRGTASTTKSGHQCQP ROR1_Hsap LPQPESPEAANCIRIGIPM-----ADPIN---KNHKCYNSTGVDYRGTVSVTKSGRQCQP Ror_Dmel LPQ-----HKDCLSLGITI------E-VD---KTENCYWEDGSTYRGVANVSASGKPCLR cam-1_Cele LSS-----TSNCIPVMSTALQSSPVAEVNRGHLTHWCYVNSGTQYEGTVAQTSSGKQCAP ROR1_Mmus LPQPESPEAANCIRIGIPM-----ADPIN---KNHKCYNSTGVDYRGTVSVTKSGRQCQP ROR2_Mmus LPMPESPDAANCMRIGIPA------ERLG---RYHQCYNGSGADYRGMASTTKSGHQCQP ROR_Spur LPAIGTNANANCIRVGLPD------VAAV---TDHKCYNDTGEDYRGRINTTKSGFACQS *. :*: : . . ** * *.* : ** * ROR2_Hsap WALQHPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVR-MELCDVPSCSPRD ROR1_Hsap WNSQYPHTHTFTALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFK-SDLCDIPACDSKD Ror_Dmel WSWLMKE-----ISDFPELI-GQNYCRNPGSVENSPWCFVDSSRERIIELCDIPKCADK- cam-1_Cele WIDST--SRDFNVHRFPELMNSKNYCRNPGGKKSRPWCYSKPM-GQ-EEYCDVPQCPSDM ROR1_Mmus WNSQYPHTHSFTALRFPELNGGHSYCRNPGNQKEAPWCFTLDENFK-SDLCDIPACDSKD ROR2_Mmus WALQHPHSHRLSSTEFPELGGGHAYCRNPGGQVEGPWCFTQNKNVR-VELCDVPPCSPRD ROR_Spur WDKQEPHEHALWPSHYRELAGGHNFCRNPGNGLDKPWCFTTNPDVR-AEKCDIPRCDELT * : ** .: :*****. . ***: : : **:* * ROR2_Hsap S------------------SKMGILYILVPS---------IAIPLVIACLFFLVCMCRNK ROR1_Hsap SK-----------E----KNKMEILYILVPS---------VAIPLAIALLFFFICVCRNN Ror_Dmel -----------------------IWIAIVGT--------TAAIILIFIIIFAIILFKRR- cam-1_Cele YPHLNDKKVEGSTKGGVSESVTALWDSLDPTMQVALVGGGVFFSLLLLLLFCCACCCRAK ROR1_Mmus SK-----------E----KNKMEILYILVPS---------VAIPLAIAFLFFFICVCRNN ROR2_Mmus G------------------SKMGILYILVPS---------IAIPLVIACLFFLVCMCRNK ROR_Spur GSG----------V----VSRPTILYIIVPA---------VTVIVVILLICGCVCFCWRQ : : : . : : : ROR2_Hsap QKASASTPQRRQLMASPSQ--------------------------D--MEMPL------- ROR1_Hsap QKSSS-APVQRQPKHVRGQ--------------------------N--VEMSM------- Ror_Dmel T-IMHYGMRNIHNINTPSADKNIYGNSQLNNAQDAGRGNLGNLSDHVALNSKL------- cam-1_Cele KKSQKTRHQNAHCSSAPSVINSAANSAYYRKLNGTSTPIMGRVPPHVEMTSLLPSAQHLG ROR1_Mmus QKSSS-PPVQRQPKPVRGQ--------------------------N--VEMSM------- ROR2_Mmus QKASASTPQRRQLMASPSQ--------------------------D--MEMPL------- ROR_Spur TKSQR-----YGGVASRTR--------------------------P--SEVVA------- ROR2_Hsap --------------------INQHK-QAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGP ROR1_Hsap --------------------LNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLYLP Ror_Dmel --------------------IERN-TLLRINHFTLQDVEFLEELGEGAFGKVYKGQLLQP cam-1_Cele PPPYPMDQHLQQARRFPSQEPIDD-NSYKVFEITPSQLSVREKIGEGQFGVVHSGIYTSG ROR1_Mmus --------------------LNAYKPKSKAKELPLSAVRFMEELGECTFGKIYKGHLYLP ROR2_Mmus --------------------ISQHK-QAKLKEISLSTVRFMEELGEDRFGKVYKGHLFGP ROR_Spur -----------------------LQQKLQVKEIPLAAIKFSEALGDGTFGKVWRGELMGL : .:. : . * :*: ** : * ROR2_Hsap APGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSY ROR1_Hsap GM-DHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEY Ror_Dmel N--KTTITVAIKALKENASVKTQQDFKREIELISDLKHQNIVCILGVVLNKEPYCMLFEY cam-1_Cele LFAPEPMAVAVKKCRHDATNAERAQLEQEIRAVATFDHPNVIKLIGVCYMDNSLLAVFEY ROR1_Mmus GM-DHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEY ROR2_Mmus APGEPTQAVAIKTLKDKAEGPLREEFRQEAMLRARLQHPNIVCLLGVVTKDQPLSMIFSY ROR_Spur NNQYSCTSIVIKTLDKEASPALQQDYRNETSVMASLNHPNIITLLGVCTKEKPNCMLFEF :.:* . : ..* : :.* *:: ::*. .:. :*.: ROR2_Hsap CSHGDLHEFLVMRSPHSDVGS-TDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHK ROR1_Hsap INQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHK Ror_Dmel MANGDLHEFLISNSPTE------------GKSLSQLEFLQIALQISEGMQYLSAHHYVHR cam-1_Cele MVHGDLHELLKVRVPPADHDMG-------GITEANAEFLYIATQIALGMEYLASMSFVHR ROR1_Mmus MNQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHK ROR2_Mmus CSHGDLHEFLVMRSPHSDVGS-TDDDRTVKSALEPPDFVHVVAQIAAGMEFLSSHHVVHK ROR_Spur LPHGDLHEFLVRHSPNSDVGFGSGDD-DTQSSLDASDFLNIAIQIVSGMDYLSSRHFVHR :*****:* . * : :*: :. ** **::*:: **: ROR2_Hsap DLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSD ROR1_Hsap DLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPPEAIMYGKFSSDSD Ror_Dmel DLAARNCLVNEGLVVKISDFGLSRDIYSSDYYRVQSKSLLPVRWMPSESILYGKFTTESD cam-1_Cele DLATRNCLVGDTRTIKIADFGLMRTSYGSDYYKMLHRSWMPVRWMSKEAIEQGRFSEASD ROR1_Mmus DLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSSLPIRWMPPEAIMYGKFSSDSD ROR2_Mmus DLATRNVLVYDKLNVRISDLGLFREVYSADYYKLMGNSLLPIRWMSPEAVMYGKFSIDSD ROR_Spur DLAARNCMVGEHHQIKITDFGLARDIYSGDYYRMPSQAVLPIRWMSPEAIMFGRFTVESD ***:** :: : ::*:*:** * *..***:: .: :*:***. *:: *:*: ** ROR2_Hsap IWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPS ROR1_Hsap IWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPS Ror_Dmel VWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSRQLLSAPENCPTAVYSLMIECWHEQSV cam-1_Cele VWSFGVTLWEIWSFGRQPYEGASNQQVIELVANRHLLECPHNCPTNIYSLMVECWHENIE ROR1_Mmus IWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPS ROR2_Mmus IWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRSRQVLPCPDDCPAWVYALMIECWNEFPS ROR_Spur IWSFGVVLWEIYSYGLQPFYGYNNNEVIEMIRTRHILPSPSGCPQYIYALMTECWSEIPA :**:**.***::*:* **: * .*::*:::: .*::* .. .** :*:** *** * ROR2_Hsap RRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARY---VGPKQ ROR1_Hsap RRPRFKDIHVRLRSWEGLSSHTSSTTPSGGNATTQTTSLSASPVSNLSNPRYPNYMFPSQ Ror_Dmel KRPTFTDISNRLKTWHEGH----------------------------------------- cam-1_Cele RRPTFSEIRSRLQSWSLASPAHSILQQH-------------------------------- ROR1_Mmus RRPRFKDIHVRLRSWEGLSSHTSSTTPSGGNATTQTTSLSASPVSNLSNPRFPNYMFPSQ ROR2_Mmus RRPRFKDIHSRLRSWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARY---MAPKQ ROR_Spur RRPPFKVISTRLRALDTVPMHTQNG------------NIYGNPAANF-NPQYSGLYSP-- :** *. * **:: ROR2_Hsap KAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQV ROR1_Hsap GITP--QGQ---IAGFIGPPIPQNQRFIPINGYPIPPGYAAFPAAHYQPTGPPRV-IQHC Ror_Dmel ------------------------------------------------------------ cam-1_Cele -----------------------------------------------------------N ROR1_Mmus GITP--QGQ---IAGFIGPAIPQNQRFIPINGYPIPPGYAAFPAAHYQPAGPPRV-IQHC ROR2_Mmus KAQPFPQPQFIPMKGQIRPLVPPAQLYIPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQV ROR_Spur --------------------------------------------------------QTHC ROR2_Hsap PPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQNAPE-DGAQSTVQ ROR1_Hsap PP---PKSRSPSSASGSTSTGHVTSLPSSGSNQEANIPLLPHMSI-PNHPGGMGITVFGN Ror_Dmel ------------------------------------------------------------ cam-1_Cele NR---AGSHSGSSGAGRPPT-HQRGYPSQKLH---------------------------- ROR1_Mmus PP---PKSRSPSSASGSTSTGHVASLPSSGSNQEANVPLLPHMSI-PNHPGGMGITVFGN ROR2_Mmus PPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSVADRAALLSEGTEDAQNIAE-DVAQSPVQ ROR_Spur SS---EGKKSHGSSGGSRH-----SQPKMGL-ADKA--MSETSS---------------- ROR2_Hsap EAEEEEEGSVPETELLGDCDTLQVDEA-QVQLEA ROR1_Hsap KSQKPYKIDSKQASLLGDANIHGHTES-MISAEL Ror_Dmel -------------------------FKA-SNPEM cam-1_Cele ---RRVEGA---SPLM-KRHDANYAYS-EDGDSD ROR1_Mmus KSQKPYKIDSKQSSLLGDSHIHGHTES-MISAEV ROR2_Mmus EAEEEEEGSVPETELLGDNDTLQVTEAAHVQLEA ROR_Spur ------------SSHHTRSTGHGKSEK-VEQTAV