CLUSTAL W (1.83) multiple sequence alignment SGK3_Hsap MQRDHTMDYK-----ESCPSVS-----------------IPS----------SDEHREKK SGK2_Hsap MQGLLTSGRKPSGG-GRCTGRGGWRG---QWCLKP----WMG----------GADPPTPT SGK1_Hsap MVNKDMNGF-PVK---KCSAFQFFKKRVRRWIKSP----MVS----------VDKHQSPS SGK1_Mmus MVNKDMNGF-PVK---KCSAFQFFKKRVRRWIKSP----MVS----------VDKHQSPN SGK2_Mmus MASS-------------------------------------------------------- SGK3_Mmus MQRDCIMDYK-----ESCPSVS-----------------IPS----------SDEHREKK W10G6.2_Cele MQKTFEEYER-------------------------------------------------- DDB0220702_Ddis MTTTISSNL-P-------S----------QLEISPTKLL-ITKQPIKL---------R-- pk2_Ddis MGKGQSKIK-NGGS-GKPAKAGKPKKGNKNDETTPTSTPTPTPTPTQQNLDNSAQQQQQQ SGK_Spur LVTDDEAIRA-TEIELTCHPIS-----------------IHS----------NH------ AqueK027_Aque ------------------------------------------------------------ SGK3_Hsap KRFTVY-KVLVSVGRSEWFV-FRRYA--------------------EFDKLYNTLKKQFP SGK2_Hsap LSCL---LLP-------------------------------------------------- SGK1_Hsap LKYTGSSMVHIPPGEPDFESSLCQTCLGEHAFQRGVLPQENESCSWETQSGCEVREPCNH SGK1_Mmus LKYTGPAGVHLPPGESDFEA-MCQSCLGDHAFQRGMLPP-EESCSWEIQPGCEVKEQCNH SGK2_Mmus ------------------------------------------------------------ SGK3_Mmus KRFTVY-KVLVSVGRSEWFV-FRRYA--------------------EFDKLYNSLKKQFP W10G6.2_Cele --------------------------------------------------FFTTEKDMIP DDB0220702_Ddis ESTESP-FK--SM----------------------------------MDTFKNTIISTSP pk2_Ddis QQTTTA-AV--SL-----------------------------------DNKEQQQQQNIP SGK_Spur -----------------------------------------------FC----------- AqueK027_Aque ------------------------------------------------------------ SGK3_Hsap AMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKHQS SGK2_Hsap -----VP-------------------------------PELPDH-CY---------RMNS SGK1_Hsap ANILTKPDPRTFWTNDDPAFMKQRRMGLNDFIQKIANNSYACKHPEVQSILKISQPQEPE SGK1_Mmus ANILTKPDPRTFWTNDDAAFMKQRRMGLNDFIQKIASNTYACKHAEVQSILKMSHPQEPE SGK2_Mmus ------------------------------------------------------------ SGK3_Mmus AMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPRHQS W10G6.2_Cele ATIFTAPKKKFL--QADSKFYEKRRVWILVISQHLVDNN--LRSEDVRRFFHLESP---- DDB0220702_Ddis TECEESSSSTI----TTPSEES-LSSG-E------------------------------- pk2_Ddis APATQTPITQT----GTPTIEESQKNTDNNNI----------NGASN------------- SGK_Spur ---------------------------------DIYNEISPKQNGEVQNFLSLDNPRNNP AqueK027_Aque -------------------FIKQRRQGLNDFIVNLIKIPSIFDDEAVRDFLSLDDQRST- SGK3_Hsap DPSE---DEDERSSQKLHSTSQN------INLG------PSGNPH--------------- SGK2_Hsap -------SPAGTPSPQPSRANGN------INLG------PSANPN--------------- SGK1_Hsap -------LMNANPSP-PPSPSQQ------INLG------PSSNPH--------------- SGK1_Mmus -------LMNANPSP-PPSPSQQ------INLG------PSSNPH--------------- SGK2_Mmus --------PVGVPSPQPSRANGN------INLG------PSANPN--------------- SGK3_Mmus DPSE---DEDERSTSKPHSTSRN------INLG------PTGNPH--------------- W10G6.2_Cele -----------------DDDENN------VDLG------PSERKT--------------- DDB0220702_Ddis -----------ESSSISDSESKI------ITIA------TLLKPSNSVQDFTPLCNGAQE pk2_Ddis -----------EASSSPDSPNGSGNGNDDEDEGPEEVIFSKNKQS--------------- SGK_Spur DNSV--ADENNTDFFSDPNDPNT------INLG------PSANPS--------------- AqueK027_Aque IPIYDRESLDEEAGS-EDKTANR------FDLG------TSEKES--------------- . . . SGK3_Hsap ---------AKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHI SGK2_Hsap ---------AQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHI SGK1_Hsap ---------AKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHI SGK1_Mmus ---------AKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHI SGK2_Mmus ---------ARPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKNKEQNHI SGK3_Mmus ---------AKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHI W10G6.2_Cele ---------ATANDFDYLTTIGKGSFGRVYQVRHKETKKIYAMKILSKEHIRKKNEVKHV DDB0220702_Ddis TEIVKISNSINLSNFIIKHLVGKGGFGKVFQVVHVDTQKVYALKVIKKNHIIAKKSVVNT pk2_Ddis ---------ATKDDFELLNVIGKGSFGKVMQVKKKGEDKIFAMKVLRKDAIIARKQVNHT SGK_Spur ---------ARPSDFDFLKVIGKGSFGKVLLAKHKIDGKVYAVKVLQKAAIVKRNEAKHI AqueK027_Aque ---------AAITDFKLLKVIGKGSFGKVYLGRHIDTNKHYAIKVLQKKAIVKRNEVKHI :* :***.:*:* : :*:*:: * : .:. : SGK3_Hsap MAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYA SGK2_Hsap MAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYA SGK1_Hsap MSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYA SGK1_Mmus MSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYA SGK2_Mmus MAERNVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYT SGK3_Mmus MAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEPRARFYA W10G6.2_Cele MAERNVLINNFKHPFLVSLHFSFQNKEKLYFVLDHLNGGELFSHLQREKHFSESRSRFYA DDB0220702_Ddis LAEKDI-LKKISHPFIVNLHYAFQNEKKLYLVMDFVNGGQLFYHLQKEAIFSEDQVRFYM pk2_Ddis KSEKTI-LQCISHPFIVNLHYAFQTKDKLYMVLDFVNGGELFFHLKREGRFSEPRVKIYA SGK_Spur MAERSVLLKNLKHPFLVSLHYSFQTADKLYFVLDYVNGGELFFHLQREKSFPEVRAKFYA AqueK027_Aque MAERNVLLRNVTHPFLVGLHYSFQTGTKLYFVLDYVNGGELFFHLQRERVFEEPRARFYA :*: : :. . ***:*.*:::**. ***:*:*.:***:** **::* * * : ::* SGK3_Hsap AEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEY SGK2_Hsap AEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEY SGK1_Hsap AEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEY SGK1_Mmus AEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNGTTSTFCGTPEY SGK2_Mmus AEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKECVEPEETTSTFCGTPEY SGK3_Mmus AEIASALGYLHSIKIVYRDLKPENILLDSMGHVVLTDFGLCKEGIAISDTTTTFCGTPEY W10G6.2_Cele AEIACALGYLHEKNIIYRDLKPENLLLDDKGYLVLTDFGLCKEDMQGSKTTSTFCGTPEY DDB0220702_Ddis AELILALEHLHDSNIVHRDLKPENILLDSQGHCILTDFGLAKLEVKTNNETFSFAGTLEY pk2_Ddis AEIVSALDHLHKQDIVYRDLKPENILLDSEGHICITDFGLSKK-IETTDGTFTFCGTPEY SGK_Spur AEIASAIGYLHSLDIIYRDLKPENILLDHDGHVRLTDFGLCKEGIAAKKTTSTFCGTPEY AqueK027_Aque AEITSALGYLHEQDIVYRDLKPENILLDKQGHIILTDFGLCKEDVKQGETTSTFCGTPEY **: *: :**. .*::*******:*** *: :*****.* : * :*.** ** SGK3_Hsap LAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLT SGK2_Hsap LAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVA SGK1_Hsap LAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNS SGK1_Mmus LAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNS SGK2_Mmus LAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFFNTDVAQMYENILHQPLQIPGGRTVA SGK3_Mmus LAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLNLRPGVSLT W10G6.2_Cele LAPEIILKKPYDKTVDWWCLGSVLYEMIFGLPPFYSKDHNEMYDKIINQPLRLKHNISVP DDB0220702_Ddis MAPEMIQHATCGKAVDWWSIGILMYDMMIGKPPFEHKNRALMQEKIISEKAKFPKFVSSS pk2_Ddis LAPEVLNGHGHGCAVDWWSLGTLLYEMLTGLPPFYSQNVSTMYQKILNGELKIPTYISPE SGK_Spur LAPEVLRKQEYDRSVDWWCLGAVLFEMMSGLS---------------------------- AqueK027_Aque LAPEVLRKQDYGRPVDWWCLGVVTYEMMYGLPPFYSRDVAEMYDGILHKPLRLRPNITPA :***:: . .****.:* : ::*: * . SGK3_Hsap AWSILEELLEKDRQNRLGAK-EDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDI SGK2_Hsap ACDLLQSLLHKDQRQRLGSK-ADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADL SGK1_Hsap ARHLLEGLLQKDRTKRLGAK-DDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDL SGK1_Mmus ARHLLEGLLQKDRTKRLGAK-DDFMEIKSHIFFSLINWDDLINKKITPPFNPNVSGPSDL SGK2_Mmus ACDLLQGLLHKDQRQRLGSK-EDFLDIKNHMFFSPINWDDLYHKRLTPPFNPNVEGPADL SGK3_Mmus AWSILEELLEKNRQNRLGAK-EDFLEIQNHPFFESLSWTDLVQKKIPPPFNPNVAGPDDI W10G6.2_Cele CSELITGLLQKDRSKRLGHR-NDFRDIRDHPFFLPVDWDKLLNRELKAPFIPKVKNAMDT DDB0220702_Ddis ARSLINGLLTKDPTKRLGAN-G-AIEIKRHPFFKSIQWRKIENKEITPPFVPSTKGIDDI pk2_Ddis AKSLLEGLLTREVDKRLGTK-G-GGEVKQHPWFKNIDWEKLDRKEVEVHFKPKVKSGTDI SGK_Spur -------------------------------------------------------DSMDV AqueK027_Aque GRSLLEGLLQKDKNHRLGSGVRDYKDIMDHLFFRSINWDDLFLKKLEPPFNPNVSGDLDL . * SGK3_Hsap RNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDL--FL SGK2_Hsap KHFDPEFTQEAVSKSIGCTPDTV---ASSSGASSAFLGFSYAPEDDDI-LDC SGK1_Hsap RHFDPEFTEEPVPNSIGKSPDSVLVTASVKEAAEAFLGFSYAPPTDS---FL SGK1_Mmus RHFDPEFTEEPVPSSIGRSPDSILVTASVKEAAEAFLGFSYAPPVDS---FL SGK2_Mmus KHFDPEFTQEAVSKSIGCTPDTV---ASSSGASSAFLGFSYAQDDDDI-LDS SGK3_Mmus RNFDAVFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDL--FL W10G6.2_Cele SNISKEFVEIQIDPSS-LAPQQL----AVTHRDHDFENFTFVDTNRV---LV DDB0220702_Ddis SNFDHASLKAHQRDSFSTSP-TL---SSS--QQAYFDGFSFVRTPVLLESQK pk2_Ddis SQIDPVFTQERPMDSLVETS-AL---GDAMGKDTSFEGFTYVADSI---LKD SGK_Spur KNIDPEFVREPVPNSVGKSVDPNTVSASVQDADNVFEGFTYVPPTVGL-DDP AqueK027_Aque RHFDQEFTNEAISDNPSP-PKSTSAGMSISVQDETFAGFSY----------I ::. . . * .*::